Caroline Elizabeth Freiermuth, MD

Bachelor of Science: Xavier University Cincinnati, Ohio, 2002 (Biology)

MD: University of Cincinnati Cincinnati, Ohio, 2006

Residency: University of Cincinnati Cincinnati, Ohio, 2010 (Emergency Medicine)

Masters of Science: Duke University Durham, NC, 2017 (Clinical Research)

American Board of Emergency Medicine (Certification Date: 06-08-2011 ) - (Recertification Date: to 01-01-2022 )

Emergency Medicine

Sickle Cell Anemia

Pain

Substance Use Disorder

Emergency Medicine

Emergency Medicine

Grant: #A030996 / UG3HL137856 Investigators:Freiermuth, Caroline 09-07-2018 -08-31-2019 National Heart, Lung and Blood Institute A comparison of individualized vs. weight based protocols to treat vaso-occlusive episodes in Sickle Cell Disease (COMPARE VOE) Role:PI $41,387.00 Awarded Level:Federal

Grant: #A032460 / UG3HL137856 Investigators:Freiermuth, Caroline 09-20-2019 -08-31-2022 National Heart, Lung and Blood Institute A comparison of individualized vs. weight based protocols to treat vaso-occlusive episodes in Sickle Cell Disease (COMPARE VOE) Role:PI $42,671.00 Awarded Level:Federal

Grant: #AGO Contract #12545 Investigators:Brown, Jennifer; Freiermuth, Caroline; Lyons, Michael; Punches, Brittany; Stolz, Uwe 03-01-2020 -02-28-2022 Ohio Attorney General Identifying genetic markers associated with opioid use disorder Role:PI $2,738,887.00 Awarded Level:State of Ohio

Grant: #Health Collab. "COVID-19 Testing and Data Collect." (US Dept Treasury) Investigators:Calhoun, Dustin; Faryar, Kiran; Freiermuth, Caroline; Lyons, Michael; Punches, Brittany; Ryan, Richard 07-01-2020 -12-30-2020 Department of Treasury Early Intervention Program: COVID-19 Testing, Reporting, and Surveillance Role:Collaborator $7,611,499.00 Awarded Level:Federal

Grant: #EMF Research Grant Investigators:Freiermuth, Caroline 12-15-2020 -12-14-2021 Emergency Medicine Foundation Better Prescribing Better Treatment Program: Innovations to Improve Opioid Prescribing for Acute Pain Role:PI $15,000.00 Awarded Level:Private Non-Profit

Grant: #03140014EC0221 Investigators:Faryar, Kiran; Freiermuth, Caroline; Lyons, Michael; Punches, Brittany; Ryan, Richard 03-01-2021 -08-31-2022 Centers for Disease Control and Prevention UC Early Intervention Program (EIP) Role:Collaborator $1,983,000.00 Awarded Level:Federal

Grant: #03140014IN0223 Investigators:Freiermuth, Caroline; Jarrell, Kelli; Lyons, Michael; Punches, Brittany 09-30-2021 -09-29-2022 Substance Abuse & Mental Health Services Administration UC Early Intervention Program - Integrated Naloxone Access and Infrastructure (IN23) Role:PI 56000.00 Active Level:Federal

Grant: #03140014EC0323 Investigators:Freiermuth, Caroline; Jarrell, Kelli; Ryan, Richard; Smith, Carolyn 09-01-2022 -08-31-2023 Centers for Disease Control and Prevention Emergency Department Comprehensive Care (EC23) Role:PI 400000.00 Awarded Level:Federal

Grant: #pending / 5 NU38OT000306-03-00 Investigators:Freiermuth, Caroline; Ryan, Richard 04-01-2023 -03-31-2024 Centers for Disease Control and Prevention Embedding Peers in the ED-Sustaining Peers in the ED Role:PI 120000.00 Hold Level:Federal

Grant: #ODMHA 2300761 (SAMHSA H79TI085753) Investigators:Freiermuth, Caroline; Ryan, Richard 09-30-2022 -09-29-2023 Substance Abuse & Mental Health Services Administration State Opioid and Stimulant Response (SOS) 3.0 Role:Collaborator 150000.00 Active Level:Federal

Grant: #H79TI085997 Investigators:Freiermuth, Caroline; Ryan, Richard 09-30-2023 -09-29-2026 Substance Abuse & Mental Health Services Administration Alternatives to opioids for pain in the Emergency Department: Implementing Integrative Health approaches and expanding local nerve block initiatives Role:PI 478958.00

Grant: #pending / NU38OT000306 Investigators:Freiermuth, Caroline; Ryan, Richard 10-01-2023 -06-30-2024 Centers for Disease Control and Prevention ED Based Substance Use Navigation - Advancing the Evidence Role:PI 99851.58 Hold Level:Federal

Grant: #03140014IN0223  Investigators:Lyons, Michael MD; Jarrell, Kelli MD 09-30-2021 -03-31-2023 Substance Abuse & Mental Health Services Administration UC Early Intervention Program - Integrated Naloxone Access and Infrastructure (IN23) Role:PI $93250.00 Active

Grant: #SOS 4.0 ADAMH Investigators:Freiermuth, Caroline 09-30-2024 -09-29-2025 Substance Abuse & Mental Health Services Administration SOS 4.0 Peer Recovery Supports Role:PI 34608.00 Hold Level:Federal

Grant: #03140014IH0225 Investigators:Freiermuth, Caroline 04-01-2025 -09-29-2025 Substance Abuse & Mental Health Services Administration Integrated Harm Reduction IH25 Role:PI 56000.00 Hold Level:Federal

Grant: #CSL889_2001 Investigators:Freiermuth, Caroline 12-31-2024 -12-17-2029 CSL Behring LLC A Phase 2 / Phase 3, Multicenter, Randomized, Multiple-Dose, Double-Blind, Placebo-Controlled Adaptive Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescen Role:PI 403413.08 Hold Level:Industry

Grant: #03140011IH0226 Investigators:Freiermuth, Caroline 09-30-2025 -09-29-2026 Substance Abuse & Mental Health Services Administration IH26 Integrated Harm Reduction Role:PI 112000.00 Awarded Level:Federal

Peer Reviewed Publications

Fulton J.J.;LeBlanc T.W.;Cutson T.M.;Porter Starr K.N.;Kamal A.;Ramos K.;Freiermuth C.E.;McDuffie J.R.;Kosinski A.;Adam S.;Nagi A.;Williams J.W.  (02-01-2019). Integrated outpatient palliative care for patients with advanced cancer: A systematic review and met. Palliative Medicine, 33 (2) , 123-134More Information

Hughes J.M.;Freiermuth C.E.;Shepherd-Banigan M.;Ragsdale L.;Eucker S.A.;Goldstein K.;Hastings S.N.;Rodriguez R.L.;Fulton J.;Ramos K.;Tabriz A.A.;Gordon A.M.;Gierisch J.M.;Kosinski A.;Williams J.W.  (01-01-2019). Emergency Department Interventions for Older Adults: A Systematic Review. Journal of the American Geriatrics SocietyMore Information

Freiermuth C.E.;Lavonas E.J.;Anderson V.E.;Kleinschmidt K.C.;Sharma K.;Rapp-Olsson M.;Gerardo C.;Bush S.;Mullins M.;Greene S.;Toschlog E.;Quackenbush E.;Rutherford Rose S.;Schwartz R.;Charlton N.;Lewis B.;Brandehoff N.  (01-01-2019). Antivenom Treatment Is Associated with Fewer Patients using Opioids after Copperhead Envenomation. Western Journal of Emergency Medicine, 20 (3) , 497-505More Information

Williams H.;Silva S.;Cline D.;Freiermuth C.;Tanabe P.  (05-01-2018). Social and behavioral factors in sickle cell disease: Employment predicts decreased health care util. Journal of Health Care for the Poor and Underserved, 29 (2) , 814-829More Information

Tanabe P.;Freiermuth C.E.;Cline D.M.;Silva S.  (03-01-2017). A prospective emergency department quality improvement project to improve the treatment of vaso-occl. Joint Commission Journal on Quality and Patient Safety, 43 (3) , 116-126More Information

Freiermuth C.E.;Silva S.;Cline D.M.;Tanabe P.  (09-01-2016). Shift in Emergency Department Provider Attitudes Toward Patients with Sickle Cell Disease. Advanced Emergency Nursing Journal, 38 (3) , 199-212More Information

Thornton V.;Holl J.;Cline D.;Freiermuth C.;Sullivan D.;Tanabe P.  (01-01-2014). Application of a proactive risk analysis to emergency department sickle cell care. Western Journal of Emergency Medicine, 15 (4) , 446-458More Information

Blomkalns, Andra L; O'Connell, Elise M; Eady, Caroline E; Lindsell, Christopher J; Gibler, W Brian  (2006). Evaluation of dyslipidemia in the emergency department: impact of cholesterol testing on subsequent therapy. American heart journal, 152 (6) , 1182-6More Information

Freiermuth, Caroline E; Kisor, David F; Lambert, Joshua; Braun, Robert; Frey, Jennifer A; Bachmann, Daniel J; Bischof, Jason J; Lyons, Michael S; Pantalon, Michael V; Punches, Brittany E; Ancona, Rachel; Sprague, Jon E  (2023). Genetic Variants Associated With Opioid Use Disorder. Clinical pharmacology and therapeutics, 113 (5) , 1089-1095More Information

D'Onofrio, Gail; Edelman, E Jennifer; Hawk, Kathryn F; Chawarski, Marek C; Pantalon, Michael V; Owens, Patricia H; Martel, Shara H; Rothman, Richard; Saheed, Mustapha; Schwartz, Robert P; Cowan, Ethan; Richardson, Lynne; Salsitz, Edwin; Lyons, Michael S; Freiermuth, Caroline; Wilder, Christine; Whiteside, Lauren; Tsui, Judith I; Klein, Jared W; Coupet, Edouard; O'Connor, Patrick G; Matthews, Abigail G; Murphy, Sean M; Huntley, Kristen; Fiellin, David A  (2023). Implementation Facilitation to Promote Emergency Department-Initiated Buprenorphine for Opioid Use Disorder. JAMA network open, 6 (4) , e235439More Information

Whiteside, Lauren K; D'Onofrio, Gail; Fiellin, David A; Edelman, E Jennifer; Richardson, Lynne; O'Connor, Patrick; Rothman, Richard E; Cowan, Ethan; Lyons, Michael S; Fockele, Callan E; Saheed, Mustapha; Freiermuth, Caroline; Punches, Brittany E; Guo, Clara; Martel, Shara; Owens, Patricia H; Coupet, Edouard; Hawk, Kathryn F  (2022). Models for Implementing Emergency Department-Initiated Buprenorphine With Referral for Ongoing Medication Treatment at Emergency Department Discharge in Diverse Academic Centers. Annals of emergency medicine, 80 (5) , 410-419More Information

Faryar, Kiran A; Braun, Robert; Ancona, Rachel M; Freiermuth, Caroline; Lyons, Michael S  (2022). Acceptance of HIV pre-exposure prophylaxis (PrEP) referral among a sample of PrEP-eligible emergency department patients. The American journal of emergency medicine, 60, 152-155More Information

Punches, Brittany E; Stolz, Uwe; Freiermuth, Caroline E; Ancona, Rachel M; McLean, Samuel A; House, Stacey L; Beaudoin, Francesca L; An, Xinming; Stevens, Jennifer S; Zeng, Donglin; Neylan, Thomas C; Clifford, Gari D; Jovanovic, Tanja; Linnstaedt, Sarah D; Germine, Laura T; Bollen, Kenneth A; Rauch, Scott L; Haran, John P; Storrow, Alan B; Lewandowski, Christopher; Musey, Paul I; Hendry, Phyllis L; Sheikh, Sophia; Jones, Christopher W; Kurz, Michael C; Gentile, Nina T; McGrath, Meghan E; Hudak, Lauren A; Pascual, Jose L; Seamon, Mark J; Harris, Erica; Chang, Anna M; Pearson, Claire; Peak, David A; Merchant, Roland C; Domeier, Robert M; Rathlev, Niels K; O'Neil, Brian J; Sanchez, Leon D; Bruce, Steven E; Pietrzak, Robert H; Joormann, Jutta; Barch, Deanna M; Pizzagalli, Diego A; Smoller, Jordan W; Luna, Beatriz; Harte, Steven E; Elliott, James M; Kessler, Ronald C; Ressler, Kerry J; Koenen, Karestan C; Lyons, Michael S  (2022). Predicting at-risk opioid use three months after ed visit for trauma: Results from the AURORA study. PloS one, 17 (9) , e0273378More Information

Bellolio, Fernanda; Broder, Joshua S; Oliveira J E Silva, Lucas; Freiermuth, Caroline E; Hooker, Edmond; Jang, Timothy B; Griffey, Richard T; Meltzer, Andrew C; Mills, Angela M; Pepper, Joan; Prakken, Steven; Repplinger, Michael D; Upadhye, Suneel; Carpenter, Christopher R  (2022). Reply to "Letter to the Editor, re: GRACE-2: Low-Risk, Recurrent Abdominal Pain in the Emergency Department". Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 29 (9) , 1148-1150More Information

Punches, Brittany E; Brown, Jennifer L; Soliman, Summer; Johnson, Kimberly D; Freiermuth, Caroline E; Walker, Quinn; Omololu, Shammah O; Lyons, Michael S  (2022). Patient Pain Experiences and the Emergency Department Encounter: A Qualitative Analysis. Pain management nursing : official journal of the American Society of Pain Management Nurses, 23 (4) , 391-396More Information

Westafer, Lauren M; Freiermuth, Caroline E; Lall, Michelle D; Muder, Sarah J; Ragone, Eleanor L; Jarman, Angela F  (2022). Experiences of Transgender and Gender Expansive Physicians. JAMA network open, 5 (6) , e2219791More Information

Broder, Joshua S; Oliveira J E Silva, Lucas; Bellolio, Fernanda; Freiermuth, Caroline E; Griffey, Richard T; Hooker, Edmond; Jang, Timothy B; Meltzer, Andrew C; Mills, Angela M; Pepper, Joan D; Prakken, Steven D; Repplinger, Michael D; Upadhye, Suneel; Carpenter, Christopher R  (2022). Guidelines for Reasonable and Appropriate Care in the Emergency Department 2 (GRACE-2): Low-risk, recurrent abdominal pain in the emergency department. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 29 (5) , 526-560More Information

Ojeda, Myriam Shaw; Chen, Aleda M H; Miracle, Tessa; Delaney, Elizabeth; Freiermuth, Caroline E; Sprague, Jon E  (2022). HealthCare educational differences in pain management, adverse childhood experiences and their relationship to substance use disorder education. Substance abuse treatment, prevention, and policy, 17 (1) , 10More Information

Punches, Brittany E; Ali, Abeer Alhaj; Brown, Jennifer L; Freiermuth, Caroline E; Clark, Angela K; Lyons, Michael SOpioid-Related Risk Screening Measures for the Emergency Care Setting. Advanced emergency nursing journal, 43 (4) , 331-343More Information

Punches, Brittany E; Berger, Kimberly M; Freiermuth, Caroline E; Soliman, Summer A; Walker, Quinn T; Lyons, Michael S  (2021). Emergency Nurse Perceptions of Pain and Opioids in the Emergency Department. Pain management nursing : official journal of the American Society of Pain Management Nurses, 22 (5) , 586-591More Information

McCorkle, Maggie L; Kisor, David F; Freiermuth, Caroline E; Sprague, Jon E  (2021). Systematic review of Pharmacogenomics Knowledgebase evidence for pharmacogenomic links to the dopamine reward pathway for heroin dependence. Pharmacogenomics, 22 (13) , 849-857More Information

Eucker, Stephanie A; Manandhar, Pratik; Arulraja, Kami; Agnihotri, Deepti; Pollack, Charles V; Freiermuth, Caroline  (2021). Higher daily pain severity after emergency department visits is associated with lower return-to-work rates. The American journal of emergency medicine, 45, 48-53More Information

Punches, Brittany E; Ancona, Rachel M; Freiermuth, Caroline E; Brown, Jennifer L; Lyons, Michael S  (2021). Incidence of opioid use disorder in the year after discharge from an emergency department encounter. Journal of the American College of Emergency Physicians open, 2 (3) , e12476More Information

Ibemere, Stephanie O; Dubbs, Sarah B; Barnhart, Huiman X; Brown, Jacqueline L; Freiermuth, Caroline E; Kavanagh, Patricia; Paice, Judith A; Strouse, John J; Wilkerson, R Gentry; Tanabe, Paula  (2021). Trial design of comparing patient-specific versus weight-based protocols to treat vaso-occlusive episodes in sickle cell disease (COMPARE-VOE). Contemporary clinical trials, 101, 106252More Information

Lane, Bennett H; Lyons, Michael S; Stolz, Uwe; Ancona, Rachel M; Ryan, Richard J; Freiermuth, Caroline E  (2021). Naloxone provision to emergency department patients recognized as high-risk for opioid use disorder. The American journal of emergency medicine, 40, 173-176More Information

Punches, Brittany E; Soliman, Summer; Freiermuth, Caroline E; Lane, Bennett H; Lyons, Michael S  (2020). Emergency Nurse Perceptions of Naloxone Distribution in the Emergency Department. Journal of emergency nursing, 46 (5) , 675-681.e1More Information

Hughes, Jaime M; Freiermuth, Caroline E; Shepherd-Banigan, Megan; Ragsdale, Luna; Eucker, Stephanie A; Goldstein, Karen; Hastings, S Nicole; Rodriguez, Rachel L; Fulton, Jessica; Ramos, Katherine; Tabriz, Amir Alishahi; Gordon, Adelaide M; Gierisch, Jennifer M; Kosinski, Andrzej; Williams, John W  (2019). Emergency Department Interventions for Older Adults: A Systematic Review. Journal of the American Geriatrics Society, 67 (7) , 1516-1525More Information

Freiermuth, Caroline E; Lavonas, Eric J; Anderson, Victoria E; Kleinschmidt, Kurt C; Sharma, Kapil; Rapp-Olsson, Malin; Gerardo, Charles  (2019). Antivenom Treatment Is Associated with Fewer Patients using Opioids after Copperhead Envenomation. The western journal of emergency medicine, 20 (3) , 497-505More Information

Fulton, Jessica J; LeBlanc, Thomas W; Cutson, Toni M; Porter Starr, Kathryn N; Kamal, Arif; Ramos, Katherine; Freiermuth, Caroline E; McDuffie, Jennifer R; Kosinski, Andrzej; Adam, Soheir; Nagi, Avishek; Williams, John W  (2019). Integrated outpatient palliative care for patients with advanced cancer: A systematic review and meta-analysis. Palliative medicine, 33 (2) , 123-134More Information

Kopec, Kathryn T; Freiermuth, Caroline; Maynard, Susan; Beuhler, Michael  (2018). Dinitrophenol (DNP) Fatality Associated with a Falsely Elevated Salicylate Level: a Case Report with Verification of Laboratory Cross Reactivity. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 14 (4) , 323-326More Information

Gunn, Alexander H; Smothers, Zachary P W; Schramm-Sapyta, Nicole; Freiermuth, Caroline E; MacEachern, Mark; Muzyk, Andrew J  (2018). The Emergency Department as an Opportunity for Naloxone Distribution. The western journal of emergency medicine, 19 (6) , 1036-1042More Information

Cline, David M; Silva, Susan; Freiermuth, Caroline E; Thornton, Victoria; Tanabe, Paula  (2018). Emergency Department (ED), ED Observation, Day Hospital, and Hospital Admissions for Adults with Sickle Cell Disease. The western journal of emergency medicine, 19 (2) , 311-318More Information

Williams, Hants; Silva, R N Susan; Cline, David; Freiermuth, Caroline; Tanabe, Paula  (2018). Social and Behavioral Factors in Sickle Cell Disease: Employment Predicts Decreased Health Care Utilization. Journal of health care for the poor and underserved, 29 (2) , 814-829More Information

Tanabe, Paula; Freiermuth, Caroline E; Cline, David M; Silva, Susan  (2017). A Prospective Emergency Department Quality Improvement Project to Improve the Treatment of Vaso-Occlusive Crisis in Sickle Cell Disease: Lessons Learned. Joint Commission journal on quality and patient safety, 43 (3) , 116-126More Information

Freiermuth, Caroline E; Silva, Susan; Cline, David M; Tanabe, Paula  (2016). Shift in Emergency Department Provider Attitudes Toward Patients With Sickle Cell Disease. Advanced emergency nursing journal, 38 (3) , 199-212More Information

Dedert, Eric A; McDuffie, Jennifer R; Stein, Roy; McNiel, J Murray; Kosinski, Andrzej S; Freiermuth, Caroline E; Hemminger, Adam; Williams, John W  (2015). Electronic Interventions for Alcohol Misuse and Alcohol Use Disorders: A Systematic Review. Annals of internal medicine, 163 (3) , 205-14More Information

Freiermuth, Caroline E; Chandra, Abhinav; Peacock, W Frank  (2015). Characteristics of patients that do not initially respond to intravenous antihypertensives in the emergency department: subanalysis of the CLUE trial. The western journal of emergency medicine, 16 (2) , 276-83More Information

Ibemere, Stephanie O; Barnhart, Huiman; Myers, John; Miller, Joseph; Osunkwo, Ifeyinwa; Bosworth, Hayden B; Freiermuth, Caroline E; Hughes, Robert; Kavanagh, Patricia L; Paice, Judith A; Paxton, James; Pierce, Ava; Runyon, Michael S; Strouse, John J; Veeramreddy, Padmaja; Wilkerson, R Gentry; Tanabe, Paula  (2025). Impact of Individualized Versus Weight-Based Pain Protocols on Patient Satisfaction for Patients With Sickle Cell Disease Experiencing a Vaso-Occlusive Episode. Journal of emergency nursing, 51 (4) , 626-635More Information

Freiermuth, Caroline E; Haywood, Carlton; Silva, Susan; Cline, David M; Kayle, Mariam; Sullivan, Dori; Thornton, Victoria; Tanabe, Paula  (2014). Attitudes toward patients with sickle cell disease in a multicenter sample of emergency department providers. Advanced emergency nursing journal, 36 (4) , 335-47More Information

Petrovitch, Dan; Himes, Katie P; Bischof, Jason J; Braun, Robert S; Brown, Jennifer L; Eleda, Isaiah C; Freiermuth, Caroline E; Gu, Shaopeng; Hall, O Trent; Johnson, Julie A; Kisor, David F; Lambert, Joshua W; Lyons, Michael S; Maloney, Morgan V; Punches, Brittany E; Quarles, Emma; Littlefield, Andrew K; Sprague, Jon E  (2025). Scoping review of associations between cytochrome P450 3A4/5 single nucleotide polymorphisms and risk factors for fentanyl overdose. Pharmacogenomics, 1-35More Information

Thornton, Victoria L; Holl, Jane L; Cline, David M; Freiermuth, Caroline E; Sullivan, Dori T; Tanabe, Paula  (2014). Application of a proactive risk analysis to emergency department sickle cell care. The western journal of emergency medicine, 15 (4) , 446-58More Information

Brown, Jennifer L; Larochelle, Marc R; Fanucchi, Laura C; Calvert, Deirdre C; Campbell, Aimee N C; Chandler, Redonna K; Feaster, Daniel J; Glasgow, LaShawn M; Gibson, Erin B; Holloway, JaNae; Lofwall, Michelle R; Mack, Aimee; Mack, Nicole; Nunes, Edward V; Talbert, Jeffery C; Tan, Sylvia; Vandergrift, Nathan; Villani, Jennifer; Asman, Kat; Babakhanlou-Chase, Hermik; Bagley, Sarah M; Battaglia, Tracy A; Blevins, Derek; Bridden, Carly; Cheng, Debbie M; Christopher, Mia; Cogan, Lindsay W; Cunningham, Chinazo O; Eggleston, Barry; Fareed, Naleef; Fernandez, Soledad; Freedman, Darcy A; Freiermuth, Caroline E; Freisthler, Bridget; Gilbert, Louisa; Hammerslag, Lindsey; Harris, Daniel; Hunt, Timothy; Hussain, Shazia; Huynh, Phuong; Jackson, Rebecca D; Kauffman, Emily B; Knott, Charles; Knudsen, Hannah K; Lefebvre, R Craig; Levin, Frances R; Massatti, Rick; McAlearney, Ann Scheck; Morgan, Jake R; Lopez, Rosie Munoz; Lounsbury, David W; Newman, Lisa; Nickels, Katrina; Oga, Emmanuel A; Oller, Devin A; Parran, Theodore V; Quinn, Maria; Ramsey, Kelly S; Rapkin, Bruce D; Salsberry, Pamela; Stein, Michael; Taylor, Jessica L; Teater, Julie; Walters, Scott T; Zarkin, Gary A; El-Bassel, Nabila; Winhusen, T John; Samet, Jeffrey H; Walsh, Sharon L  (2025). Effects of the Communities That HEAL intervention on initiation, retention, and linkage to medications for opioid use disorder (MOUD): A cluster randomized wait-list controlled trial. Drug and alcohol dependence, 274, 112785More Information

Petrovitch, Dan; Himes, Katie P; Quarles, Emma; Freiermuth, Caroline E; Braun, Robert S; Lambert, Joshua W; Brown, Jennifer L; Lyons, Michael S; Punches, Brittany E; Sprague, Jon E; Littlefield, Andrew K  (2025). Negative urgency accounts for associations between internalizing symptoms and lifetime nonfatal opioid overdose among patients from three urban Ohio emergency departments. Experimental and clinical psychopharmacology, 33 (3) , 300-309More Information

Freiermuth, Caroline E; Foster, Jenny A; Manandhar, Pratik; Arulraja, Evangeline; Erkanli, Alaattin; Pollack, Charles V; Eucker, Stephanie A  (2024). Opioid Treatment Is Associated with Recurrent Healthcare Visits, Increased Side Effects, and Pain. The western journal of emergency medicine, 25 (6) , 875-882More Information

Himes, Katie P; Dan Petrovitch, M A; Freiermuth, Caroline E; Bachmann, Daniel J; Bischof, Jason J; Braun, Robert S; Brown, Jennifer L; Frey, Jennifer A; Lyons, Michael S; Pantalon, Michael V; Punches, Brittany E; Sprague, Jon E; Littlefield, Andrew K  (2024). Are opioid use disorder assessments in the emergency department biased? An examination across sex, race, and employment status using item response theory. General hospital psychiatry, 91, 186-189More Information

McMonagle, Brianna N; Braun, Robert; Luke, Jude; Goel, Anita; Freiermuth, Caroline  (2025). Patient Acceptance of Rapid HIV Testing During Targeted Screening in the Emergency Department. The western journal of emergency medicine, 26 (4) , 1124-1126More Information

Sabedra, Alexa; Freiermuth, Caroline; Santen, Sally; Leenellett, Elizabeth  (2025). Faculty development committee: Evolution through engagement and empowerment. AEM education and training, 9 (Suppl 1) , S66-S72More Information

Littlefield, Andrew K; Himes, Katie P; Petrovitch, Dan; Freiermuth, Caroline E; Braun, Robert S; Brown, Jennifer L; Bischof, Jason J; Punches, Brittany E; Sprague, Jon E  (2024). The relations between impulsivity, opioid use, and nonmedical prescription opioid use motives: An examination within three large urban emergency departments. Experimental and clinical psychopharmacology, 32 (6) , 652-663More Information

Petrovitch, Dan; Himes, Katie P; Jump, Alayna; Freiermuth, Caroline E; Braun, Robert S; Brown, Jennifer L; Lyons, Michael S; Punches, Brittany E; Sprague, Jon E; Littlefield, Andrew K  (2024). State program enables the identification of factors associated with naloxone awareness, self-efficacy, and use for overdose reversal: A cross-sectional, observational study in an urban emergency department population. Journal of substance use and addiction treatment, 167, 209506More Information

Lambert, Joshua; Petrovitch, Dan; Himes, Katie P; Freiermuth, Caroline E; Braun, Robert S; Brown, Jennifer L; Bischof, Jason J; Lyons, Michael S; Punches, Brittany E; Littlefield, Andrew K; Kisor, David F; Sprague, Jon E  (2024). Association of genetic variants in CYP3A5, DRD2 and NK1R with opioid overdose. Chemico-biological interactions, 403, 111242More Information

Sprague, Jon E; Freiermuth, Caroline E; Lambert, Joshua; Braun, Robert; Frey, Jennifer A; Bachmann, Daniel J; Bischof, Jason J; Beaumont, Lauren; Lyons, Michael S; Pantalon, Michael V; Punches, Brittany E; Ancona, Rachel; Kisor, David F  (2024). Opioid use disorder risk alleles in self-reported assigned African American/Afro-Caribbean and European biogeographical genetic ancestry groups and in males and females. The pharmacogenomics journal, 24 (4) , 23More Information

Punches, Brittany E; Freiermuth, Caroline E; Sprague, Jon E; Brown, Jennifer L; Hutzel-Dunham, Elizabeth; Lambert, Joshua; Braun, Robert; Littlefield, Andrew; Frey, Jennifer A; Bachmann, Daniel J; Bischof, Jason J; Pantalon, Michael V; Ancona, Rachel M; Kisor, David F; Lyons, Michael S  (2024). Screening for problematic opioid use in the emergency department: Comparison of two screening measures. Journal of the American College of Emergency Physicians open, 5 (1) , e13106More Information

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Tanabe, Paula; Ibemere, Stephanie; Pierce, Ava E; Freiermuth, Caroline E; Bosworth, Hayden B; Yang, Hongqui; Osunkwo, Ifeyinwa; Paxton, James H; Strouse, John J; Miller, Joseph; Paice, Judith A; Veeramreddy, Padmaja; Kavanagh, Patricia L; Wilkerson, R Gentry; Hughes, Robert; Barnhart, Huiman X  (2023). A comparison of the effect of patient-specific versus weight-based protocols to treat vaso-occlusive episodes in the emergency department. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 30 (12) , 1210-1222More Information

Freiermuth, Caroline E; Ancona, Rachel M; Brown, Jennifer L; Punches, Brittany E; Ryan, Shawn A; Ingram, Tim; Lyons, Michael S  (2023). Evaluation of a large-scale health department naloxone distribution program: Per capita naloxone distribution and overdose morality. PloS one, 18 (8) , e0289959More Information