Caroline Elizabeth Freiermuth , MD

Bachelor of Science: Xavier University Cincinnati, Ohio, 2002 (Biology)

MD: University of Cincinnati Cincinnati, Ohio, 2006

Residency: University of Cincinnati Cincinnati, Ohio, 2010 (Emergency Medicine)

Masters of Science: Duke University Durham, NC, 2017 (Clinical Research)

American Board of Emergency Medicine (Certification Date: 06-08-2011 ) - (Recertification Date: to 01-01-2022 )

Emergency Medicine

Sickle Cell Anemia

Pain

Substance Use Disorder

Emergency Medicine

Emergency Medicine

Grant: #A030996 / UG3HL137856 Investigators:Freiermuth, Caroline 09-07-2018 -08-31-2019 National Heart, Lung and Blood Institute A comparison of individualized vs. weight based protocols to treat vaso-occlusive episodes in Sickle Cell Disease (COMPARE VOE) Role:PI $41,387.00 Awarded Level:Federal

Grant: #A032460 / UG3HL137856 Investigators:Freiermuth, Caroline 09-20-2019 -08-31-2022 National Heart, Lung and Blood Institute A comparison of individualized vs. weight based protocols to treat vaso-occlusive episodes in Sickle Cell Disease (COMPARE VOE) Role:PI $42,671.00 Awarded Level:Federal

Grant: #AGO Contract #12545 Investigators:Brown, Jennifer; Freiermuth, Caroline; Lyons, Michael; Punches, Brittany; Stolz, Uwe 03-01-2020 -02-28-2022 Ohio Attorney General Identifying genetic markers associated with opioid use disorder Role:PI $2,738,887.00 Awarded Level:State of Ohio

Grant: #Health Collab. "COVID-19 Testing and Data Collect." (US Dept Treasury) Investigators:Calhoun, Dustin; Faryar, Kiran; Freiermuth, Caroline; Lyons, Michael; Punches, Brittany; Ryan, Richard 07-01-2020 -12-30-2020 Department of Treasury Early Intervention Program: COVID-19 Testing, Reporting, and Surveillance Role:Collaborator $7,611,499.00 Awarded Level:Federal

Grant: #EMF Research Grant Investigators:Freiermuth, Caroline 12-15-2020 -12-14-2021 Emergency Medicine Foundation Better Prescribing Better Treatment Program: Innovations to Improve Opioid Prescribing for Acute Pain Role:PI $15,000.00 Awarded Level:Private Non-Profit

Grant: #03140014EC0221 Investigators:Faryar, Kiran; Freiermuth, Caroline; Lyons, Michael; Punches, Brittany; Ryan, Richard 03-01-2021 -08-31-2022 Centers for Disease Control and Prevention UC Early Intervention Program (EIP) Role:Collaborator $1,983,000.00 Awarded Level:Federal

Grant: #03140014IN0223 Investigators:Freiermuth, Caroline; Jarrell, Kelli; Lyons, Michael; Punches, Brittany 09-30-2021 -09-29-2022 Substance Abuse & Mental Health Services Administration UC Early Intervention Program - Integrated Naloxone Access and Infrastructure (IN23) Role:PI 56000.00 Active Level:Federal

Grant: #03140014EC0323 Investigators:Freiermuth, Caroline; Jarrell, Kelli; Ryan, Richard; Smith, Carolyn 09-01-2022 -08-31-2023 Centers for Disease Control and Prevention Emergency Department Comprehensive Care (EC23) Role:PI 400000.00 Awarded Level:Federal

Grant: #pending / 5 NU38OT000306-03-00 Investigators:Freiermuth, Caroline; Ryan, Richard 04-01-2023 -03-31-2024 Centers for Disease Control and Prevention Embedding Peers in the ED-Sustaining Peers in the ED Role:PI 120000.00 Hold Level:Federal

Grant: #ODMHA 2300761 (SAMHSA H79TI085753) Investigators:Freiermuth, Caroline; Ryan, Richard 09-30-2022 -09-29-2023 Substance Abuse & Mental Health Services Administration State Opioid and Stimulant Response (SOS) 3.0 Role:Collaborator 150000.00 Active Level:Federal

Grant: #H79TI085997 Investigators:Freiermuth, Caroline; Ryan, Richard 09-30-2023 -09-29-2026 Substance Abuse & Mental Health Services Administration Alternatives to opioids for pain in the Emergency Department: Implementing Integrative Health approaches and expanding local nerve block initiatives Role:PI 478958.00

Grant: #pending / NU38OT000306 Investigators:Freiermuth, Caroline; Ryan, Richard 10-01-2023 -06-30-2024 Centers for Disease Control and Prevention ED Based Substance Use Navigation - Advancing the Evidence Role:PI 99851.58 Hold Level:Federal

Grant: #03140014IN0223  Investigators:Lyons, Michael MD; Jarrell, Kelli MD 09-30-2021 -03-31-2023 Substance Abuse & Mental Health Services Administration UC Early Intervention Program - Integrated Naloxone Access and Infrastructure (IN23) Role:PI $93250.00 Active

Grant: #SOS 4.0 ADAMH Investigators:Freiermuth, Caroline 09-30-2024 -09-29-2025 Substance Abuse & Mental Health Services Administration SOS 4.0 Peer Recovery Supports Role:PI 34608.00 Hold Level:Federal

Grant: #03140014IH0225 Investigators:Freiermuth, Caroline 04-01-2025 -09-29-2025 Substance Abuse & Mental Health Services Administration Integrated Harm Reduction IH25 Role:PI 56000.00 Hold Level:Federal

Peer Reviewed Publications

Fulton J.J.;LeBlanc T.W.;Cutson T.M.;Porter Starr K.N.;Kamal A.;Ramos K.;Freiermuth C.E.;McDuffie J.R.;Kosinski A.;Adam S.;Nagi A.;Williams J.W. (02-01-2019. ) Integrated outpatient palliative care for patients with advanced cancer: A systematic review and met.Palliative Medicine, , 33 (2 ) ,123-134 More Information

Hughes J.M.;Freiermuth C.E.;Shepherd-Banigan M.;Ragsdale L.;Eucker S.A.;Goldstein K.;Hastings S.N.;Rodriguez R.L.;Fulton J.;Ramos K.;Tabriz A.A.;Gordon A.M.;Gierisch J.M.;Kosinski A.;Williams J.W. (01-01-2019. ) Emergency Department Interventions for Older Adults: A Systematic Review.Journal of the American Geriatrics Society, , More Information

Freiermuth C.E.;Lavonas E.J.;Anderson V.E.;Kleinschmidt K.C.;Sharma K.;Rapp-Olsson M.;Gerardo C.;Bush S.;Mullins M.;Greene S.;Toschlog E.;Quackenbush E.;Rutherford Rose S.;Schwartz R.;Charlton N.;Lewis B.;Brandehoff N. (01-01-2019. ) Antivenom Treatment Is Associated with Fewer Patients using Opioids after Copperhead Envenomation.Western Journal of Emergency Medicine, , 20 (3 ) ,497-505 More Information

Williams H.;Silva S.;Cline D.;Freiermuth C.;Tanabe P. (05-01-2018. ) Social and behavioral factors in sickle cell disease: Employment predicts decreased health care util.Journal of Health Care for the Poor and Underserved, , 29 (2 ) ,814-829 More Information

Tanabe P.;Freiermuth C.E.;Cline D.M.;Silva S. (03-01-2017. ) A prospective emergency department quality improvement project to improve the treatment of vaso-occl.Joint Commission Journal on Quality and Patient Safety, , 43 (3 ) ,116-126 More Information

Freiermuth C.E.;Silva S.;Cline D.M.;Tanabe P. (09-01-2016. ) Shift in Emergency Department Provider Attitudes Toward Patients with Sickle Cell Disease.Advanced Emergency Nursing Journal, , 38 (3 ) ,199-212 More Information

Thornton V.;Holl J.;Cline D.;Freiermuth C.;Sullivan D.;Tanabe P. (01-01-2014. ) Application of a proactive risk analysis to emergency department sickle cell care.Western Journal of Emergency Medicine, , 15 (4 ) ,446-458 More Information

Blomkalns, Andra L; O'Connell, Elise M; Eady, Caroline E; Lindsell, Christopher J; Gibler, W Brian (2006. ) Evaluation of dyslipidemia in the emergency department: impact of cholesterol testing on subsequent therapy.American heart journal, , 152 (6 ) ,1182-6 More Information

Freiermuth, Caroline E; Kisor, David F; Lambert, Joshua; Braun, Robert; Frey, Jennifer A; Bachmann, Daniel J; Bischof, Jason J; Lyons, Michael S; Pantalon, Michael V; Punches, Brittany E; Ancona, Rachel; Sprague, Jon E (2023. ) Genetic Variants Associated With Opioid Use Disorder.Clinical pharmacology and therapeutics, , 113 (5 ) ,1089-1095 More Information

D'Onofrio, Gail; Edelman, E Jennifer; Hawk, Kathryn F; Chawarski, Marek C; Pantalon, Michael V; Owens, Patricia H; Martel, Shara H; Rothman, Richard; Saheed, Mustapha; Schwartz, Robert P; Cowan, Ethan; Richardson, Lynne; Salsitz, Edwin; Lyons, Michael S; Freiermuth, Caroline; Wilder, Christine; Whiteside, Lauren; Tsui, Judith I; Klein, Jared W; Coupet, Edouard; O'Connor, Patrick G; Matthews, Abigail G; Murphy, Sean M; Huntley, Kristen; Fiellin, David A (2023. ) Implementation Facilitation to Promote Emergency Department-Initiated Buprenorphine for Opioid Use Disorder.JAMA network open, , 6 (4 ) ,e235439 More Information

Whiteside, Lauren K; D'Onofrio, Gail; Fiellin, David A; Edelman, E Jennifer; Richardson, Lynne; O'Connor, Patrick; Rothman, Richard E; Cowan, Ethan; Lyons, Michael S; Fockele, Callan E; Saheed, Mustapha; Freiermuth, Caroline; Punches, Brittany E; Guo, Clara; Martel, Shara; Owens, Patricia H; Coupet, Edouard; Hawk, Kathryn F (2022. ) Models for Implementing Emergency Department-Initiated Buprenorphine With Referral for Ongoing Medication Treatment at Emergency Department Discharge in Diverse Academic Centers.Annals of emergency medicine, , 80 (5 ) ,410-419 More Information

Faryar, Kiran A; Braun, Robert; Ancona, Rachel M; Freiermuth, Caroline; Lyons, Michael S (2022. ) Acceptance of HIV pre-exposure prophylaxis (PrEP) referral among a sample of PrEP-eligible emergency department patients.The American journal of emergency medicine, , 60 ,152-155 More Information

Punches, Brittany E; Stolz, Uwe; Freiermuth, Caroline E; Ancona, Rachel M; McLean, Samuel A; House, Stacey L; Beaudoin, Francesca L; An, Xinming; Stevens, Jennifer S; Zeng, Donglin; Neylan, Thomas C; Clifford, Gari D; Jovanovic, Tanja; Linnstaedt, Sarah D; Germine, Laura T; Bollen, Kenneth A; Rauch, Scott L; Haran, John P; Storrow, Alan B; Lewandowski, Christopher; Musey, Paul I; Hendry, Phyllis L; Sheikh, Sophia; Jones, Christopher W; Kurz, Michael C; Gentile, Nina T; McGrath, Meghan E; Hudak, Lauren A; Pascual, Jose L; Seamon, Mark J; Harris, Erica; Chang, Anna M; Pearson, Claire; Peak, David A; Merchant, Roland C; Domeier, Robert M; Rathlev, Niels K; O'Neil, Brian J; Sanchez, Leon D; Bruce, Steven E; Pietrzak, Robert H; Joormann, Jutta; Barch, Deanna M; Pizzagalli, Diego A; Smoller, Jordan W; Luna, Beatriz; Harte, Steven E; Elliott, James M; Kessler, Ronald C; Ressler, Kerry J; Koenen, Karestan C; Lyons, Michael S (2022. ) Predicting at-risk opioid use three months after ed visit for trauma: Results from the AURORA study.PloS one, , 17 (9 ) ,e0273378 More Information

Bellolio, Fernanda; Broder, Joshua S; Oliveira J E Silva, Lucas; Freiermuth, Caroline E; Hooker, Edmond; Jang, Timothy B; Griffey, Richard T; Meltzer, Andrew C; Mills, Angela M; Pepper, Joan; Prakken, Steven; Repplinger, Michael D; Upadhye, Suneel; Carpenter, Christopher R (2022. ) Reply to "Letter to the Editor, re: GRACE-2: Low-Risk, Recurrent Abdominal Pain in the Emergency Department".Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, , 29 (9 ) ,1148-1150 More Information

Punches, Brittany E; Brown, Jennifer L; Soliman, Summer; Johnson, Kimberly D; Freiermuth, Caroline E; Walker, Quinn; Omololu, Shammah O; Lyons, Michael S (2022. ) Patient Pain Experiences and the Emergency Department Encounter: A Qualitative Analysis.Pain management nursing : official journal of the American Society of Pain Management Nurses, , 23 (4 ) ,391-396 More Information

Westafer, Lauren M; Freiermuth, Caroline E; Lall, Michelle D; Muder, Sarah J; Ragone, Eleanor L; Jarman, Angela F (2022. ) Experiences of Transgender and Gender Expansive Physicians.JAMA network open, , 5 (6 ) ,e2219791 More Information

Broder, Joshua S; Oliveira J E Silva, Lucas; Bellolio, Fernanda; Freiermuth, Caroline E; Griffey, Richard T; Hooker, Edmond; Jang, Timothy B; Meltzer, Andrew C; Mills, Angela M; Pepper, Joan D; Prakken, Steven D; Repplinger, Michael D; Upadhye, Suneel; Carpenter, Christopher R (2022. ) Guidelines for Reasonable and Appropriate Care in the Emergency Department 2 (GRACE-2): Low-risk, recurrent abdominal pain in the emergency department.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, , 29 (5 ) ,526-560 More Information

Ojeda, Myriam Shaw; Chen, Aleda M H; Miracle, Tessa; Delaney, Elizabeth; Freiermuth, Caroline E; Sprague, Jon E (2022. ) HealthCare educational differences in pain management, adverse childhood experiences and their relationship to substance use disorder education.Substance abuse treatment, prevention, and policy, , 17 (1 ) ,10 More Information

Punches, Brittany E; Ali, Abeer Alhaj; Brown, Jennifer L; Freiermuth, Caroline E; Clark, Angela K; Lyons, Michael S Opioid-Related Risk Screening Measures for the Emergency Care Setting.Advanced emergency nursing journal, , 43 (4 ) ,331-343 More Information

Punches, Brittany E; Berger, Kimberly M; Freiermuth, Caroline E; Soliman, Summer A; Walker, Quinn T; Lyons, Michael S (2021. ) Emergency Nurse Perceptions of Pain and Opioids in the Emergency Department.Pain management nursing : official journal of the American Society of Pain Management Nurses, , 22 (5 ) ,586-591 More Information

McCorkle, Maggie L; Kisor, David F; Freiermuth, Caroline E; Sprague, Jon E (2021. ) Systematic review of Pharmacogenomics Knowledgebase evidence for pharmacogenomic links to the dopamine reward pathway for heroin dependence.Pharmacogenomics, , 22 (13 ) ,849-857 More Information

Eucker, Stephanie A; Manandhar, Pratik; Arulraja, Kami; Agnihotri, Deepti; Pollack, Charles V; Freiermuth, Caroline (2021. ) Higher daily pain severity after emergency department visits is associated with lower return-to-work rates.The American journal of emergency medicine, , 45 ,48-53 More Information

Punches, Brittany E; Ancona, Rachel M; Freiermuth, Caroline E; Brown, Jennifer L; Lyons, Michael S (2021. ) Incidence of opioid use disorder in the year after discharge from an emergency department encounter.Journal of the American College of Emergency Physicians open, , 2 (3 ) ,e12476 More Information

Ibemere, Stephanie O; Dubbs, Sarah B; Barnhart, Huiman X; Brown, Jacqueline L; Freiermuth, Caroline E; Kavanagh, Patricia; Paice, Judith A; Strouse, John J; Wilkerson, R Gentry; Tanabe, Paula (2021. ) Trial design of comparing patient-specific versus weight-based protocols to treat vaso-occlusive episodes in sickle cell disease (COMPARE-VOE).Contemporary clinical trials, , 101 ,106252 More Information

Lane, Bennett H; Lyons, Michael S; Stolz, Uwe; Ancona, Rachel M; Ryan, Richard J; Freiermuth, Caroline E (2021. ) Naloxone provision to emergency department patients recognized as high-risk for opioid use disorder.The American journal of emergency medicine, , 40 ,173-176 More Information

Punches, Brittany E; Soliman, Summer; Freiermuth, Caroline E; Lane, Bennett H; Lyons, Michael S (2020. ) Emergency Nurse Perceptions of Naloxone Distribution in the Emergency Department.Journal of emergency nursing, , 46 (5 ) ,675-681.e1 More Information

Hughes, Jaime M; Freiermuth, Caroline E; Shepherd-Banigan, Megan; Ragsdale, Luna; Eucker, Stephanie A; Goldstein, Karen; Hastings, S Nicole; Rodriguez, Rachel L; Fulton, Jessica; Ramos, Katherine; Tabriz, Amir Alishahi; Gordon, Adelaide M; Gierisch, Jennifer M; Kosinski, Andrzej; Williams, John W (2019. ) Emergency Department Interventions for Older Adults: A Systematic Review.Journal of the American Geriatrics Society, , 67 (7 ) ,1516-1525 More Information

Freiermuth, Caroline E; Lavonas, Eric J; Anderson, Victoria E; Kleinschmidt, Kurt C; Sharma, Kapil; Rapp-Olsson, Malin; Gerardo, Charles (2019. ) Antivenom Treatment Is Associated with Fewer Patients using Opioids after Copperhead Envenomation.The western journal of emergency medicine, , 20 (3 ) ,497-505 More Information

Fulton, Jessica J; LeBlanc, Thomas W; Cutson, Toni M; Porter Starr, Kathryn N; Kamal, Arif; Ramos, Katherine; Freiermuth, Caroline E; McDuffie, Jennifer R; Kosinski, Andrzej; Adam, Soheir; Nagi, Avishek; Williams, John W (2019. ) Integrated outpatient palliative care for patients with advanced cancer: A systematic review and meta-analysis.Palliative medicine, , 33 (2 ) ,123-134 More Information

Kopec, Kathryn T; Freiermuth, Caroline; Maynard, Susan; Beuhler, Michael (2018. ) Dinitrophenol (DNP) Fatality Associated with a Falsely Elevated Salicylate Level: a Case Report with Verification of Laboratory Cross Reactivity.Journal of medical toxicology : official journal of the American College of Medical Toxicology, , 14 (4 ) ,323-326 More Information

Gunn, Alexander H; Smothers, Zachary P W; Schramm-Sapyta, Nicole; Freiermuth, Caroline E; MacEachern, Mark; Muzyk, Andrew J (2018. ) The Emergency Department as an Opportunity for Naloxone Distribution.The western journal of emergency medicine, , 19 (6 ) ,1036-1042 More Information

Cline, David M; Silva, Susan; Freiermuth, Caroline E; Thornton, Victoria; Tanabe, Paula (2018. ) Emergency Department (ED), ED Observation, Day Hospital, and Hospital Admissions for Adults with Sickle Cell Disease.The western journal of emergency medicine, , 19 (2 ) ,311-318 More Information

Williams, Hants; Silva, R N Susan; Cline, David; Freiermuth, Caroline; Tanabe, Paula (2018. ) Social and Behavioral Factors in Sickle Cell Disease: Employment Predicts Decreased Health Care Utilization.Journal of health care for the poor and underserved, , 29 (2 ) ,814-829 More Information

Tanabe, Paula; Freiermuth, Caroline E; Cline, David M; Silva, Susan (2017. ) A Prospective Emergency Department Quality Improvement Project to Improve the Treatment of Vaso-Occlusive Crisis in Sickle Cell Disease: Lessons Learned.Joint Commission journal on quality and patient safety, , 43 (3 ) ,116-126 More Information

Freiermuth, Caroline E; Silva, Susan; Cline, David M; Tanabe, Paula (2016. ) Shift in Emergency Department Provider Attitudes Toward Patients With Sickle Cell Disease.Advanced emergency nursing journal, , 38 (3 ) ,199-212 More Information

Dedert, Eric A; McDuffie, Jennifer R; Stein, Roy; McNiel, J Murray; Kosinski, Andrzej S; Freiermuth, Caroline E; Hemminger, Adam; Williams, John W (2015. ) Electronic Interventions for Alcohol Misuse and Alcohol Use Disorders: A Systematic Review.Annals of internal medicine, , 163 (3 ) ,205-14 More Information

Freiermuth, Caroline E; Chandra, Abhinav; Peacock, W Frank (2015. ) Characteristics of patients that do not initially respond to intravenous antihypertensives in the emergency department: subanalysis of the CLUE trial.The western journal of emergency medicine, , 16 (2 ) ,276-83 More Information

Freiermuth, Caroline E; Haywood, Carlton; Silva, Susan; Cline, David M; Kayle, Mariam; Sullivan, Dori; Thornton, Victoria; Tanabe, Paula (2014. ) Attitudes toward patients with sickle cell disease in a multicenter sample of emergency department providers.Advanced emergency nursing journal, , 36 (4 ) ,335-47 More Information

Thornton, Victoria L; Holl, Jane L; Cline, David M; Freiermuth, Caroline E; Sullivan, Dori T; Tanabe, Paula (2014. ) Application of a proactive risk analysis to emergency department sickle cell care.The western journal of emergency medicine, , 15 (4 ) ,446-58 More Information