Mohamed Effat

Mohamed A. Effat

Professor of Clinical Medicine; Chief, Interventional Cardiology Section; Director, Interventional Cardiology Fellowship Program

Medical Sciences Building

3465

COM IM Cardiology B - 0542

Medical Sciences Building
231 Albert Sabin Way, ML 0542
Cincinnati, Ohio 45267

Education

Medical Degree, Cairo University Faculty of Medicine 1985

Transitional Residency , University of South Dakota Sioux Falls, SD , 1992

Internal Medicine Residency , University of South Dakota 1992 (Internal Medicine )

Cardiovascular Disease Fellowship , Lahey Clinic 1998 (Cardiology )

Interventional Cardiology Fellowship , University of Cincinnati 2007 (Interventional Cardiology )

Positions and Work Experience

2002 -2005 Consulting Associate, Duke University,

2005 -2006 Instructor of Medicine, University of Cincinnati, Cincinnati, OH

2007 -To Present Associate Professor, University of Cincinnati, Cincinnati, OH

Research and Practice Interests

My research focuses on physiological assessment of coronary artery disease in the cardiac catherization laboratory.

UC Health Clinical Focus

Cardiology

Cardiology Interventional

Cardiovascular Disease

UC Health Specialities

Cardiovascular Disease

Internal Medicine

Interventional Cardiology

Research Support

Investigators:MA Effat A Multicenter, Double-Blind, Randomized Study to Establish the Clinical Benefir and Safety of Vytorin (Ezetimibe/Srimvastatin Tablet) vs Simvastatin Monotherapy in High-Risk Subjects Presenting with Acute Coronary Syndrome (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial - IMPROVE IT) Role:PI

Investigators:MA Effat Sympathetic Nervous System Modulation in Hypertension by Beta-adrenergic Blockade Role:PI

Investigators:MA Effat A Randomized, Double-Blind, Double-Dummy, Parallel Group, Phase 3 Efficacy and Safety Study of CGT-2168 Compared with Clopidogrel to Reduce Upper Gastrointestinal Events Including Bleeding and Symptomatic Ulcer Disease Role:PI

Investigators:MA Effat A clinical trial comparing Cangrelor to clopidogrel in Subjects who require Percutaneous Coronary Intervention (CHAMPION PCI) Role:Sub-Investigator

Investigators:MA Effat A Clinical Trial Comparing Treatment with Cangrelor (in combination with Usual Care) to Usual Care, in Subjects Who Require Percutaneous Coronary Intervention (CHAMPION PLATFORM) Role:Sub-Investigator

Grant: #SRS 005015 Investigators:Effat, Mohamed; Gerson, Myron; Reif, Max; Syed, Faisal 07-01-2007 -12-31-2008 American Society of Nuclear Cardiology Sympathetic Nervous Modulation in Hypertension by Beta-Adrenergic Blockade Role:PI $25,000.00 Closed Level:Private Non-Profit

Grant: #NS 2008-029 Investigators:Effat, Mohamed; Leesar, Massoud 03-04-2008 -01-31-2015 National Heart, Lung and Blood Institute Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) Role:PI $147,700.00 Active Level:Federal

Grant: #Ticagrelor Study #000502291 Investigators:Effat, Mohamed 07-01-2014 -06-30-2015 University of Alabama at Birmingham Pharmacodynamic Effects of Ticagrelor and Eptifibatide Bolus-Only versus Ticagrelor and Eptifibatide Bolus plus Abbreviated Infusion in Patients Undergoing Percutaneous Coronary Intervension Role:PI $183,290.00 Active Level:Institution of Higher Education

Publications

Peer Reviewed Publications

Kolli, Kranthi K; Banerjee, R K; Peelukhana, Srikara V; Helmy, T A; Leesar, M A; Arif, Imran; Schneeberger, E W; Hand, Dwight; Succop, Paul; Gottliebson, W M; Effat, M A (2011. )Influence of heart rate on fractional flow reserve, pressure drop coefficient, and lesion flow coefficient for epicardial coronary stenosis in a porcine model.American journal of physiology. Heart and circulatory physiology, ,300 (1 ),H382-7

Hakeem, Abdul; Khan, Faisal M; Bhatti, Sabha; Samad, Zainab; Effat, Mohamed A; Eckman, Mark H; Helmy, Tarek (2009. )Provisional vs. complex stenting strategy for coronary bifurcation lesions: meta-analysis of randomized trials. The Journal of invasive cardiology, ,21 (11 ),589-95

Banerjee, Rupak K; Ashtekar, Koustubh D; Effat, Mohamed A; Helmy, Tarek A; Kim, Edward; Schneeberger, Eric W; Sinha, Roy A; Gottliebson, William M; Back, Lloyd H (2009. )Concurrent assessment of epicardial coronary artery stenosis and microvascular dysfunction using diagnostic endpoints derived from fundamental fluid dynamics principles. The Journal of invasive cardiology, ,21 (10 ),511-7

Banerjee, Rupak K; Ashtekar, Koustubh D; Helmy, Tarek A; Effat, Mohamed A; Back, Lloyd H; Khoury, Saeb F (2008. )Hemodynamic diagnostics of epicardial coronary stenoses: in-vitro experimental and computational study.Biomedical engineering online, ,7 ,24

Effat, M A (1995. )Pathophysiology of ischemic heart disease: an overview. AACN clinical issues, ,6 (3 ),369-74

Kolli, Kranthi K; Effat, M A; Peelukhana, Srikara V; Succop, Paul; Back, Lloyd H; Leesar, M A; Helmy, T A; Imran, Arif; Banerjee, R K (2014. )Hyperemia-free delineation of epicardial and microvascular impairments using a Basal index.Annals of biomedical engineering, ,42 (8 ),1681-90

Alsidawi, Said; Effat, Mohamed; Helmy, Tarek (2014. )Advances in interventional cardiology: MitraClip.Journal of thrombosis and thrombolysis, ,38 (2 ),260-8

Peelukhana, Srikara V; Kerr, Hanan; Kolli, Kranthi K; Fernandez-Ulloa, Mariano; Gerson, Myron; Effat, Mohamed; Arif, Imran; Helmy, Tarek; Banerjee, Rupak (2014. )Benefit of cardiac N-13 PET CFR for combined anatomical and functional diagnosis of ischemic coronary artery disease: a pilot study.Annals of nuclear medicine, ,

Alsidawi, Said; Effat, Mohamad (2014. )Peri-procedural management of anti-platelets and anticoagulation in patients undergoing MitraClip procedure.Journal of thrombosis and thrombolysis, ,

Kolli, Kranthi K; Arif, Imran; Peelukhana, Srikara V; Succop, Paul; Back, Lloyd H; Helmy, Tarek A; Leesar, Massoud A; Effat, Mohamed A; Banerjee, Rupak K (2014. )Diagnostic performance of pressure drop coefficient in relation to fractional flow reserve and coronary flow reserve. The Journal of invasive cardiology, ,26 (5 ),188-95

Kolli, Kranthi K; Helmy, Tarek A; Peelukhana, Srikara V; Arif, Imran; Leesar, Massoud A; Back, Lloyd H; Banerjee, Rupak K; Effat, Mohamed A (2014. )Functional diagnosis of coronary stenoses using pressure drop coefficient: a pilot study in humans.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, ,83 (3 ),377-85

Peelukhana, Srikara Viswanath; Kolli, Kranthi K; Leesar, Massoud A; Effat, Mohamed A; Helmy, Tarek A; Arif, Imran; Schneeberger, Eric W; Succop, Paul; Banerjee, Rupak K (2014. )Effect of myocardial contractility on hemodynamic end points under concomitant microvascular disease in a porcine model.Heart and vessels, ,29 (1 ),97-109

Rahman, Shahid; Leesar, Tara; Cilingiroglu, Mehmet; Effat, Mohamed; Arif, Imran; Helmy, Tarek; Leesar, Massoud A (2013. )Impact of kissing balloon inflation on the main vessel stent volume, area, and symmetry after side-branch dilation in patients with coronary bifurcation lesions: a serial volumetric intravascular ultrasound study.JACC. Cardiovascular interventions, ,6 (9 ),923-31

Kolli, Kranthi K; Paul, Anup K; Back, Lloyd H; Effat, Mohamed A; Banerjee, Rupak K (2013. )Optimization of balloon obstruction for simulating equivalent pressure drop in physiological stenoses.Biorheology, ,50 (5-6 ),257-68

Peelukhana, S V; Banerjee, R K; Kolli, K K; Effat, M A; Helmy, T A; Leesar, M A; Schneeberger, E W; Succop, P; Gottliebson, W; Irif, A (2012. )Effect of heart rate on hemodynamic endpoints under concomitant microvascular disease in a porcine model.American journal of physiology. Heart and circulatory physiology, ,302 (8 ),H1563-73

Kolli, Kranthi K; Banerjee, R K; Peelukhana, Srikara V; Effat, M A; Leesar, M A; Arif, Imran; Schneeberger, E W; Succop, Paul; Gottliebson, W M; Helmy, Tarek A (2012. )Effect of changes in contractility on pressure drop coefficient and fractional flow reserve in a porcine model. The Journal of invasive cardiology, ,24 (1 ),6-12

Hakeem, Abdul; Helmy, Tarek; Munsif, Siddharth; Bhatti, Sabha; Mazraeshahi, Reza; Cilingiroglu, Mehmet; Effat, Mohamed; Leesar, Massoud; Arif, Imran (2011. )Safety and efficacy of drug eluting stents compared with bare metal stents for saphenous vein graft interventions: a comprehensive meta-analysis of randomized trials and observational studies comprising 7,994 patients.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, ,77 (3 ),343-55

Hakeem, Abdul; Bhatti, Sabha; Arif, Imran; Effat, Mohamed; Cilingiroglu, Mehmet Fibrinolytic therapy for very late stent thrombosis--is it a viable option?.Cardiovascular revascularization medicine : including molecular interventions, ,11 (4 ),264.e13-5

Effat M; Alsidawi S (2013. )The Role of Bivalirudin in Percutaneous Coronary Interention. Cardiol Pharmacol, ,Dec 2 ,e120

Effat, Mohamad; Leesar, Massoud A (2012. )Left main coronary stenosis and acute myocardial infarction: stent or surgery? An evolving perspective.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, ,79 (6 ),988-9

Kolli, Kranthi K; van de Hoef, Tim P; Effat, Mohamed A; Banerjee, Rupak K; Peelukhana, Srikara V; Succop, Paul; Leesar, Massoud A; Imran, Arif; Piek, Jan J; Helmy, Tarek A (2015. )Diagnostic cutoff for pressure drop coefficient in relation to fractional flow reserve and coronary flow reserve: A Patient-Level Analysis.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, ,

Alsidawi, Said; Effat, Mohamed; Rahman, Shahid; Abdallah, Mouhamad; Leesar, Massoud (2015. )The role of vascular imaging in guiding routine Percutaneous Coronary Interventions: A meta-analysis of Bare Metal Stent and Drug-Eluting Stent trials.Cardiovascular therapeutics, ,

Cannon, Christopher P; Blazing, Michael A; Giugliano, Robert P; McCagg, Amy; White, Jennifer A; Theroux, Pierre; Darius, Harald; Lewis, Basil S; Ophuis, Ton Oude; Jukema, J Wouter; De Ferrari, Gaetano M; Ruzyllo, Witold; De Lucca, Paul; Im, KyungAh; Bohula, Erin A; Reist, Craig; Wiviott, Stephen D; Tershakovec, Andrew M; Musliner, Thomas A; Braunwald, Eugene; Califf, Robert M (2015. )Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes.The New England journal of medicine, ,372 (25 ),2387-97

Kereiakes, Dean J; Yeh, Robert W; Massaro, Joseph M; Driscoll-Shempp, Priscilla; Cutlip, Donald E; Steg, P Gabriel; Gershlick, Anthony H; Darius, Harald; Meredith, Ian T; Ormiston, John; Tanguay, Jean Francois; Windecker, Stephan; Garratt, Kirk N; Kandzari, David E; Lee, David P; Simon, Daniel I; Iancu, Adrian Corneliu; Trebacz, Jaroslaw; Mauri, Laura (2015. )Antiplatelet therapy duration following bare metal or drug-eluting coronary stents: the dual antiplatelet therapy randomized clinical trial.JAMA, ,313 (11 ),1113-21

Peelukhana, Srikara V; Effat, Mohamed; Kolli, Kranthi K; Arif, Imran; Helmy, Tarek; Leesar, Massoud; Kerr, Hanan; Back, Lloyd H; Banerjee, Rupak (2015. )Lesion flow coefficient: a combined anatomical and functional parameter for detection of coronary artery disease--a clinical study. The Journal of invasive cardiology, ,27 (1 ),54-64

Mauri, Laura; Kereiakes, Dean J; Yeh, Robert W; Driscoll-Shempp, Priscilla; Cutlip, Donald E; Steg, P Gabriel; Normand, Sharon-Lise T; Braunwald, Eugene; Wiviott, Stephen D; Cohen, David J; Holmes, David R; Krucoff, Mitchell W; Hermiller, James; Dauerman, Harold L; Simon, Daniel I; Kandzari, David E; Garratt, Kirk N; Lee, David P; Pow, Thomas K; Ver Lee, Peter; Rinaldi, Michael J; Massaro, Joseph M (2014. )Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents.The New England journal of medicine, ,371 (23 ),2155-66

Yeh, Robert W; Secemsky, Eric A; Kereiakes, Dean J; Normand, Sharon-Lise T; Gershlick, Anthony H; Cohen, David J; Spertus, John A; Steg, Philippe Gabriel; Cutlip, Donald E; Rinaldi, Michael J; Camenzind, Edoardo; Wijns, William; Apruzzese, Patricia K; Song, Yang; Massaro, Joseph M; Mauri, Laura (2016. )Development and Validation of a Prediction Rule for Benefit and Harm of Dual Antiplatelet Therapy Beyond 1 Year After Percutaneous Coronary Intervention.JAMA, ,315 (16 ),1735-49

Robbins N, Gilbert M, Kumar M, McNamara JW, Daly P, Koch SE, Conway G, Effat M, Woo JG, Sadayappan S, Rubinstein J. (2018. )Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro. J Am Heart Assoc, ,13 (7 ),2

Hebbar UU, Effat MA, Peelukhana SV, Arif I, Banerjee RK. (2017. )Delineation of epicardial stenosis in patients with microvascular disease using pressure drop coefficient: A pilot outcome study. World J Cardiol, ,26 (9 ),813

Peelukhana SV, Banerjee RK, van de Hoef TP, Kolli KK, Effat M, Helmy T, Leesar M, Kerr H, Piek JJ, Succop P, Back L, Arif I. (2017. )Evaluation of lesion flow coefficient for the detection of coronary artery disease in patient groups from two academic medical centers. Cardiovasc Revasc Med, ,S1553 (17 ),30340

Effat MA, Peelukhana SV, Banerjee RK. (2016. )Clinical outcomes of combined flow-pressure drop measurements using newly developed diagnostic endpoint: Pressure drop coefficient in patients with coronary artery dysfunction. World J Cardiol, ,26 (8 ),283

Kolli KK, van de Hoef TP, Effat MA, Banerjee RK, Peelukhana SV, Succop P, Leesar MA, Imran A, Piek JJ, Helmy TA. (2016. )Diagnostic cutoff for pressure drop coefficient in relation to fractional flow reserve and coronary flow reserve: A patient-level analysis .Catheter Cardiovasc Interv, ,87 (2 ),273

Peelukhana SV, Banerjee R, Kolli KK, Fernandez-Ulloa M, Arif I, Effat M, Helmy T, Kerr H. (2015. )Benefit of ECG-gated rest and stress N-13 cardiac PET imaging for quantification of LVEF in ischemic patients.Nucl Med Commun, ,36 (10 ),968

Abo-Salem E, Alsidawi S, Jamali H, Effat M, Helmy T. (2015. )Optimal Duration of Dual Antiplatelet Therapy after Drug-Eluting Stents: Meta-Analysis of Randomized Trials.Cardiovasc Ther, ,33 (5 ),253

Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Jensen EC, Magnani G, Bansilal S, Fish MP, Im K, Bengtsson O, Oude Ophuis T, Budaj A, Theroux P, Ruda M, Hamm C, Goto S, Spinar J, Nicolau JC, Kiss RG, Murphy SA, Wiviott SD, Held P, Braunwald E, Sabatine MS; PEGASUS-TIMI 54 Steering Committee and Investigators (2015. )Long-term use of ticagrelor in patients with prior myocardial infarction .N Engl J Med, ,372 (19 ),1791

Honors and Awards

2007 -2008 Noble Fowler Faculty Teaching Award University of Cincinnati

2007 Nuclear Cardiology Foundation Award/Research Grant

2001 Fellowship of the American College of Cardiology

1996 Fellows Award American Heart Association- Genentech

1995 Teaching Award University of South Dakota School of Medicine

1992 -1993 Chairman's Award University of South Dakota Department of Medicine

1985 Students Scientific Society Kasr El-Eini (S.S.S.)

1979 -1982 Scholarship of the Department of Education for Outstanding Undergraduates

Keywords

heart, cardiac, heart disease, cardiovascular, cardiology

Contact Information

Academic - Medical Sciences Building
231 Albert Sabin Way, ML 0542
CincinnatiĀ  Ohio, 45267
Phone: 513-558-4272
Fax: 513-558-6899
mohamed.effat@uc.edu