Dalia A El-Gamal , PHD,MS

Peer Reviewed Publications

Lone, Waseem; Bouska, Alyssa; Herek, Tyler A; Amador, Catalina; Song, Joo; Xu, Alexander M; Jochum, Dylan; Issa, Issa Ismail; Weisenburger, Dennis D; Zhang, Xuan; Bhagavathi, Sharath Kumar; Heavican-Foral, Tayla B; Sharma, Sunandini; Shah, Ab Rauf; Mir, Abdul Rouf; Alkhinji, Aisha Ahmad; El-Gamal, Dalia; Dave, Bhavana J; Hartert, Keenan; Yu, Jiayu; Saumyaranjan, Mallick; Greiner, Timothy C; Vose, Julie; McKeithan, Timothy W; Fu, Kai; Green, Michael; Bi, Chengfeng; Merchant, Akil; Chan, Wing C; Iqbal, Javeed (2025. ) High-grade B-cell lymphoma not otherwise specified, with diffuse large B-cell lymphoma gene expression signatures: Genomic analysis and potential therapeutics.American journal of hematology, , 100 (1 ) ,10-22 More Information

Schmitz, Elizabeth; Ridout, Abigail; Smith, Audrey L; Eiken, Alexandria P; Skupa, Sydney A; Drengler, Erin M; Singh, Sarbjit; Rana, Sandeep; Natarajan, Amarnath; El-Gamal, Dalia (2024. ) Immunogenic Cell Death Traits Emitted from Chronic Lymphocytic Leukemia Cells Following Treatment with a Novel Anti-Cancer Agent, SpiD3.Biomedicines, , 12 (12 ) , More Information

Zablonski, Kevin G; Skupa, Sydney A; Eiken, Alexandria P; Sundaram, Suchitra; Mavis, Cory; Gu, Juan Jenny; Torka, Pallawi; Ghione, Paola; El-Gamal, Dalia; Hernandez-Ilizaliturri, Francisco J (2024. ) Targeted BET inhibition with OPN-51107 synergizes with venetoclax in chronic lymphocytic leukemia.Leukemia & lymphoma, , 65 (14 ) ,2129-2137 More Information

Eiken, Alexandria P; Schmitz, Elizabeth; Drengler, Erin M; Smith, Audrey L; Skupa, Sydney A; Mohan, Kabhilan; Rana, Sandeep; Singh, Sarbjit; Mallareddy, Jayapal Reddy; Mathew, Grinu; Natarajan, Amarnath; El-Gamal, Dalia (2024. ) The Novel Anti-Cancer Agent, SpiD3, Is Cytotoxic in CLL Cells Resistant to Ibrutinib or Venetoclax.Hemato, , 5 (3 ) ,321-339 More Information

Mahr, Anna R; Bennett-Boehm, Maia M C; Rothemejer, Frederik H; Weber, Isabelle S; Regan, Alexander K; Franzen, Josh Q; Bisson, Cami R; Truong, Angela N; Olesen, Rikke; Schleimann, Mariane H; Rauter, Claudia M; Smith, Audrey L; El-Gamal, Dalia; Søgaard, Ole S; Tolstrup, Martin; Denton, Paul W (2024. ) TLR9 agonism differentially impacts human NK cell-mediated direct killing and antibody-dependent cell-mediated cytotoxicity.Scientific reports, , 14 (1 ) ,14595 More Information

Smith, Audrey L; Skupa, Sydney A; Eiken, Alexandria P; Reznicek, Timothy E; Schmitz, Elizabeth; Williams, Nolan; Moore, Dalia Y; D'Angelo, Christopher R; Kallam, Avyakta; Lunning, Matthew A; Bociek, R Gregory; Vose, Julie M; Mohamed, Eslam; Mahr, Anna R; Denton, Paul W; Powell, Ben; Bollag, Gideon; Rowley, M Jordan; El-Gamal, Dalia (2024. ) BET inhibition reforms the immune microenvironment and alleviates T cell dysfunction in chronic lymphocytic leukemia.JCI insight, , 9 (10 ) , More Information

Eiken, Alexandria P; Smith, Audrey L; Skupa, Sydney A; Schmitz, Elizabeth; Rana, Sandeep; Singh, Sarbjit; Kumar, Siddhartha; Mallareddy, Jayapal Reddy; de Cubas, Aguirre A; Krishna, Akshay; Kalluchi, Achyuth; Rowley, M Jordan; D'Angelo, Christopher R; Lunning, Matthew A; Bociek, R Gregory; Vose, Julie M; Natarajan, Amarnath; El-Gamal, Dalia (2024. ) Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects.Cancer research communications, , 4 (5 ) ,1328-1343 More Information

Eiken, Alexandria P; El-Gamal, Dalia (2023. ) Editorial for the IJMS Special Issue on Molecular Pathogenesis and Molecular Therapy of Lymphoid Malignancies.International journal of molecular sciences, , 25 (1 ) , More Information

Smith, Audrey L; Pal, Dhananjaya; Martinez-Rico, Rolando; Eiken, Alexandria P; Durden, Donald L; Kutateladze, Tatiana G; El-Gamal, Dalia (2023. ) Preclinical activity of a novel multi-axis inhibitor in aggressive and indolent B-cell malignancies.Leukemia & lymphoma, , 64 (14 ) ,2333-2337 More Information

Upadhyay Banskota, Shristi; Skupa, Sydney A; El-Gamal, Dalia; D'Angelo, Christopher R (2023. ) Defining the Role of the Gut Microbiome in the Pathogenesis and Treatment of Lymphoid Malignancies.International journal of molecular sciences, , 24 (3 ) , More Information

D'Angelo, Christopher; Sudakaran, Sailendharan; Asimakopoulos, Fotis; Hematti, Peiman; El-Gamal, Dalia; Safdar, Nasia; Callander, Natalie (2023. ) Perturbation of the gut microbiome and association with outcomes following autologous stem cell transplantation in patients with multiple myeloma.Leukemia & lymphoma, , 64 (1 ) ,87-97 More Information

Vann, Kendra R; Acharya, Arpan; Jang, Suk Min; Lachance, Catherine; Zandian, Mohamad; Holt, Tina A; Smith, Audrey L; Pandey, Kabita; Durden, Donald L; El-Gamal, Dalia; Côté, Jacques; Byrareddy, Siddappa N; Kutateladze, Tatiana G (2022. ) Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.Structure (London, England : 1993), , 30 (9 ) ,1224-1232.e5 More Information

Smith, Audrey L; Eiken, Alexandria P; Skupa, Sydney A; Moore, Dalia Y; Umeta, Lelisse T; Smith, Lynette M; Lyden, Elizabeth R; D'Angelo, Christopher R; Kallam, Avyakta; Vose, Julie M; Kutateladze, Tatiana G; El-Gamal, Dalia (2022. ) A Novel Triple-Action Inhibitor Targeting B-Cell Receptor Signaling and BRD4 Demonstrates Preclinical Activity in Chronic Lymphocytic Leukemia.International journal of molecular sciences, , 23 (12 ) , More Information

Struble, Lucas R; Smith, Audrey L; Lutz, William E; Grubbs, Gabrielle; Sagar, Satish; Bayles, Kenneth W; Radhakrishnan, Prakash; Khurana, Surender; El-Gamal, Dalia; Borgstahl, Gloria E O (2022. ) Insect cell expression and purification of recombinant SARS-COV-2 spike proteins that demonstrate ACE2 binding.Protein science : a publication of the Protein Society, , 31 (5 ) ,e4300 More Information

Vann, Kendra R; Pal, Dhananjaya; Smith, Audrey L; Sahar, Namood-E; Krishnaiah, Maddeboina; El-Gamal, Dalia; Kutateladze, Tatiana G (2022. ) Combinatorial inhibition of BTK, PI3K-AKT and BRD4-MYC as a strategy for treatment of mantle cell lymphoma.Molecular biomedicine, , 3 (1 ) ,2 More Information

Pal, Dhananjaya; Vann, Kendra R; Joshi, Shweta; Sahar, Namood E; Morales, Guillermo A; El-Gamal, Dalia; Kutateladze, Tatiana G; Durden, Donald L (2021. ) The BTK/PI3K/BRD4 axis inhibitor SRX3262 overcomes Ibrutinib resistance in mantle cell lymphoma.iScience, , 24 (9 ) ,102931 More Information

Gilham, Dean; Smith, Audrey L; Fu, Li; Moore, Dalia Y; Muralidharan, Abenaya; Reid, St Patrick M; Stotz, Stephanie C; Johansson, Jan O; Sweeney, Michael; Wong, Norman C W; Kulikowski, Ewelina; El-Gamal, Dalia (2021. ) Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro.Biomedicines, , 9 (4 ) , More Information

Ozer, Hatice Gulcin; El-Gamal, Dalia; Powell, Ben; Hing, Zachary A; Blachly, James S; Harrington, Bonnie; Mitchell, Shaneice; Grieselhuber, Nicole R; Williams, Katie; Lai, Tzung-Huei; Alinari, Lapo; Baiocchi, Robert A; Brinton, Lindsey; Baskin, Elizabeth; Cannon, Matthew; Beaver, Larry; Goettl, Virginia M; Lucas, David M; Woyach, Jennifer A; Sampath, Deepa; Lehman, Amy M; Yu, Lianbo; Zhang, Jiazhong; Ma, Yan; Zhang, Ying; Spevak, Wayne; Shi, Songyuan; Severson, Paul; Shellooe, Rafe; Carias, Heidi; Tsang, Garson; Dong, Ken; Ewing, Todd; Marimuthu, Adhirai; Tantoy, Christina; Walters, Jason; Sanftner, Laura; Rezaei, Hamid; Nespi, Marika; Matusow, Bernice; Habets, Gaston; Ibrahim, Prabha; Zhang, Chao; Mathé, Ewy A; Bollag, Gideon; Byrd, John C; Lapalombella, Rosa (2018. ) BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.Cancer discovery, , 8 (4 ) ,458-477 More Information

Bottoni, Arianna; Rizzotto, Lara; Lai, Tzung-Huei; Liu, Chaomei; Smith, Lisa L; Mantel, Rose; Reiff, Sean; El-Gamal, Dalia; Larkin, Karilyn; Johnson, Amy J; Lapalombella, Rosa; Lehman, Amy; Plunkett, William; Byrd, John C; Blachly, James S; Woyach, Jennifer A; Sampath, Deepa (2016. ) Targeting BTK through microRNA in chronic lymphocytic leukemia.Blood, , 128 (26 ) ,3101-3112 More Information

Hing, Z A; Fung, H Y J; Ranganathan, P; Mitchell, S; El-Gamal, D; Woyach, J A; Williams, K; Goettl, V M; Smith, J; Yu, X; Meng, X; Sun, Q; Cagatay, T; Lehman, A M; Lucas, D M; Baloglu, E; Shacham, S; Kauffman, M G; Byrd, J C; Chook, Y M; Garzon, R; Lapalombella, R (2016. ) Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.Leukemia, , 30 (12 ) ,2364-2372 More Information

El-Gamal, Dalia; Rao, Shailaja P; Holzer, Michael; Hallström, Seth; Haybaeck, Johannes; Gauster, Martin; Wadsack, Christian; Kozina, Andrijana; Frank, Saša; Schicho, Rudolf; Schuligoi, Rufina; Heinemann, Akos; Marsche, Gunther (2014. ) The urea decomposition product cyanate promotes endothelial dysfunction.Kidney international, , 86 (5 ) ,923-31 More Information

El-Gamal, Dalia; Williams, Katie; LaFollette, Taylor D; Cannon, Matthew; Blachly, James S; Zhong, Yiming; Woyach, Jennifer A; Williams, Erich; Awan, Farrukh T; Jones, Jeffrey; Andritsos, Leslie; Maddocks, Kami; Wu, Chia-Hsien; Chen, Ching-Shih; Lehman, Amy; Zhang, Xiaoli; Lapalombella, Rosa; Byrd, John C (2014. ) PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL.Blood, , 124 (9 ) ,1481-91 More Information

Zhong, Y; El-Gamal, D; Dubovsky, J A; Beckwith, K A; Harrington, B K; Williams, K E; Goettl, V M; Jha, S; Mo, X; Jones, J A; Flynn, J M; Maddocks, K J; Andritsos, L A; McCauley, D; Shacham, S; Kauffman, M; Byrd, J C; Lapalombella, R (2014. ) Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.Leukemia, , 28 (5 ) ,1158-63 More Information

Binder, Veronika; Ljubojevic, Senka; Haybaeck, Johannes; Holzer, Michael; El-Gamal, Dalia; Schicho, Rudolf; Pieske, Burkert; Heinemann, Akos; Marsche, Gunther (2013. ) The myeloperoxidase product hypochlorous acid generates irreversible high-density lipoprotein receptor inhibitors.Arteriosclerosis, thrombosis, and vascular biology, , 33 (5 ) ,1020-7 More Information

Holzer, Michael; Zangger, Klaus; El-Gamal, Dalia; Binder, Veronika; Curcic, Sanja; Konya, Viktoria; Schuligoi, Rufina; Heinemann, Akos; Marsche, Gunther (2012. ) Myeloperoxidase-derived chlorinating species induce protein carbamylation through decomposition of thiocyanate and urea: novel pathways generating dysfunctional high-density lipoprotein.Antioxidants & redox signaling, , 17 (8 ) ,1043-52 More Information

Holzer, Michael; Wolf, Peter; Curcic, Sanja; Birner-Gruenberger, Ruth; Weger, Wolfgang; Inzinger, Martin; El-Gamal, Dalia; Wadsack, Christian; Heinemann, Akos; Marsche, Gunther (2012. ) Psoriasis alters HDL composition and cholesterol efflux capacity.Journal of lipid research, , 53 (8 ) ,1618-24 More Information

El-Gamal, Dalia; Holzer, Michael; Gauster, Martin; Schicho, Rudolf; Binder, Veronika; Konya, Viktoria; Wadsack, Christian; Schuligoi, Rufina; Heinemann, Akos; Marsche, Gunther (2012. ) Cyanate is a novel inducer of endothelial icam-1 expression.Antioxidants & redox signaling, , 16 (2 ) ,129-37 More Information

Holzer, Michael; Birner-Gruenberger, Ruth; Stojakovic, Tatjana; El-Gamal, Dalia; Binder, Veronika; Wadsack, Christian; Heinemann, Akos; Marsche, Gunther (2011. ) Uremia alters HDL composition and function.Journal of the American Society of Nephrology : JASN, , 22 (9 ) ,1631-41 More Information