Ola Amr Elgamal, PhD

Grant: #New Idea Award Investigators:Elgamal, Ola 01-01-2025 -12-31-2025 CancerFree Kids Identify the impact of targeting DHODH on AML and immune surveillance Role:PI 50000.00 Awarded Level:Non Profit

Grant: #R01CA292084 Investigators:Bartolacci, Caterina; Byrd, John; Curran, Emily; Elgamal, Ola; Hertlein, Erin; Rai, Shesh; Scaglioni, Pier 04-01-2025 -03-31-2030 National Cancer Institute Pharmacodynamically directed targeted therapy for leukemia Role:Collaborator 0.00 Hold Level:Federal

Peer Reviewed Publications

Bray, Julie K; Elgamal, Ola A; Jiang, Jinmai; Wright, Lais S; Sutaria, Dhruvitkumar S; Badawi, Mohamed; Borcyk, Madeline G; Liu, Xiuli; Fredenburg, Kristianna M; Campbell-Thompson, Martha L; Schmittgen, Thomas D  (2020). Loss of RE-1 silencing transcription factor accelerates exocrine damage from pancreatic injury. Cell death & disease, 11 (2) , 138More Information

Elgamal, Ola A; Mehmood, Abeera; Jeon, Jae Yoon; Carmichael, Bridget; Lehman, Amy; Orwick, Shelley J; Truxall, Jean; Goettl, Virginia M; Wasmuth, Ronni; Tran, Minh; Mitchell, Shaneice; Lapalombella, Rosa; Eathiraj, Sudharshan; Schwartz, Brian; Stegmaier, Kimberly; Baker, Sharyn D; Hertlein, Erin; Byrd, John C  (2020). Preclinical efficacy for a novel tyrosine kinase inhibitor, ArQule 531 against acute myeloid leukemia. Journal of hematology & oncology, 13 (1) , 8More Information

Sutaria, Dhruvitkumar S; Jiang, Jinmai; Elgamal, Ola A; Pomeroy, Steven M; Badawi, Mohamed; Zhu, Xiaohua; Pavlovicz, Ryan; Azevedo-Pouly, Ana Clara P; Chalmers, Jeffrey; Li, Chenglong; Phelps, Mitch A; Schmittgen, Thomas D  (2017). Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery. Journal of extracellular vesicles, 6 (1) , 1333882More Information

Zhu, Xiaohua; Badawi, Mohamed; Pomeroy, Steven; Sutaria, Dhruvitkumar S; Xie, Zhiliang; Baek, Alice; Jiang, Jinmai; Elgamal, Ola A; Mo, Xiaokui; Perle, Krista La; Chalmers, Jeffrey; Schmittgen, Thomas D; Phelps, Mitch A  (2017). Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells. Journal of extracellular vesicles, 6 (1) , 1324730More Information

Azevedo-Pouly, Ana Clara P; Sutaria, Dhruvitkumar S; Jiang, Jinmai; Elgamal, Ola A; Amari, Foued; Allard, David; Grippo, Paul J; Coppola, Vincenzo; Schmittgen, Thomas D  (2017). miR-216 and miR-217 expression is reduced in transgenic mouse models of pancreatic adenocarcinoma, knockout of miR-216/miR-217 host gene is embryonic lethal. Functional & integrative genomics, 17 (2-3) , 203-212More Information

Rosas, Lucia E; Elgamal, Ola A; Mo, Xiaokui; Phelps, Mitch A; Schmittgen, Thomas D; Papenfuss, Tracey L  (2016). In vitro immunotoxicity assessment of culture-derived extracellular vesicles in human monocytes. Journal of immunotoxicology, 13 (5) , 652-65More Information

Jiang, Jinmai; Azevedo-Pouly, Ana Clara P; Redis, Roxana S; Lee, Eun Joo; Gusev, Yuriy; Allard, David; Sutaria, Dhruvitkumar S; Badawi, Mohamed; Elgamal, Ola A; Lerner, Megan R; Brackett, Daniel J; Calin, George A; Schmittgen, Thomas D  (2016). Globally increased ultraconserved noncoding RNA expression in pancreatic adenocarcinoma. Oncotarget, 7 (33) , 53165-53177More Information

Azevedo-Pouly, Ana Clara P; Elgamal, Ola A; Schmittgen, Thomas D  (2014). RNA isolation from mouse pancreas: a ribonuclease-rich tissue. Journal of visualized experiments : JoVE (90) , e51779More Information

Elgamal, Ola A; Park, Jong-Kook; Gusev, Yuriy; Azevedo-Pouly, Ana Clara P; Jiang, Jinmai; Roopra, Avtar; Schmittgen, Thomas D  (2013). Tumor suppressive function of mir-205 in breast cancer is linked to HMGB3 regulation. PloS one, 8 (10) , e76402More Information

Elgamal, Ola A; Fobare, Sydney; Vibhute, Sandip; Mehmood, Abeera; Vroom, Dennis C; Johnson, Mariah L; Stearns, Blaise; Lerma, James R; Truxall, Jean; Stahl, Emily; Carmichael, Bridget; Orwick, Shelley J; Mims, Alice S; Curran, Emily; Santhanam, Ramasamy; Tridandapani, Susheela; Phelps, Mitch A; Xie, Zhiliang; Coss, Christopher C; Baker, Sharyn D; Patrick, Jeffrey; Ezzell, Janel K; Rai, Jayesh; Pan, Jianmin; Rai, Shesh N; Stillwell, Cody; Wunderlich, Mark; Abdulrahim, Mouad; Goodwin, Thomas E; Hilinski, Gerard; Bennett, Chad E; Hertlein, Erin; Byrd, John C  (2024). Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia. JCI insight, 9 (8) More Information

Fobare, Sydney; Elgamal, Ola A; Wunderlich, Mark; Stahl, Emily; Mehmood, Abeera; Furby, Casie; Lerma, James R; Sesterhenn, Thomas M; Pan, Jianmin; Rai, Jayesh; Johnstone, Megan E; Abdul-Aziz, Amina; Johnson, Mariah L; Rai, Shesh N; Byrd, John C; Hertlein, Erin  (2024). Inhibition of Enhancer of Zeste Homolog 2 Induces Blast Differentiation, Impairs Engraftment and Prolongs Survival in Murine Models of Acute Myeloid Leukemia. Cancers, 16 (3) More Information

Elgamal, Ola A; Fobare, Sydney; Vibhute, Sandip; Mehmood, Abeera; Vroom, Dennis C; Johnson, Mariah L; Stearns, Blaise; Lerma, James R; Truxall, Jean; Stahl, Emily; Carmichael, Bridget; Orwick, Shelley J; Mims, Alice S; Curran, Emily; Santhanam, Ramasamy; Tridandapani, Susheela; Phelps, Mitch A; Xie, Zhiliang; Coss, Christopher C; Baker, Sharyn D; Patrick, Jeffrey; Ezzell, Janel K; Rai, Jayesh; Pan, Jianmin; Rai, Shesh N; Stillwell, Cody; Wunderlich, Mark; Abdulrahim, Mouad; Goodwin, Thomas E; Hilinski, Gerard; Bennett, Chad E; Hertlein, Erin; Byrd, John C  (2024). Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia. JCI insight, 9 (8) More Information

Fobare, Sydney; Elgamal, Ola A; Wunderlich, Mark; Stahl, Emily; Mehmood, Abeera; Furby, Casie; Lerma, James R; Sesterhenn, Thomas M; Pan, Jianmin; Rai, Jayesh; Johnstone, Megan E; Abdul-Aziz, Amina; Johnson, Mariah L; Rai, Shesh N; Byrd, John C; Hertlein, Erin  (2024). Inhibition of Enhancer of Zeste Homolog 2 Induces Blast Differentiation, Impairs Engraftment and Prolongs Survival in Murine Models of Acute Myeloid Leukemia. Cancers, 16 (3) More Information