Jean Elwing , MD

B.S.: St. Louis University St. Louis, MO, 1993 (Biology)

Medical Degree: St. Louis University St. Louis, MO, 1997 (With Distinction in Community Service)

Residency : St. Louis University St. Louis, MO, 2001 (Internal Medicine/Pediatrics )

Chief Resident : St. Louis University St. Louis, MO, 2002 (Internal Medicine )

Fellowship : University of Cincinnati Cincinnati, OH, 2006 (Adult Pulmonary/Critical Care )

American Board of Internal Medicine (Pulmonary Disease) (Certification Date: 11-07-2006 ) - (Recertification Date: to 10-05-2016 )

Critical Care Medicine

Internal Medicine

Lung Disease

Pulmonary Disease

Pulmonary Embolism

Pulmonary Hypertension

Chronic Cough

Dyspnea

Histoplasmosis

Legionnaires' Disease (Legionellosis)

Pleurisy

Pneumonia

Pulmonary Atresia

Pulmonary Heart Disease

Pulmonary Sclerosing Hemangioma

Pulmonary Stenosis

Pulmonary Valve Insufficiency

Pulmonary Valve Stenosis

Pulmonary Vascular Disease (PVD)

Respiration Disorders

Respiratory Syncytial Virus (RSV)

Respiratory Tract Disease

Respiratory Tract Infections

Shortness of Breath

Thoracic Disease

Tuberculosis

Whooping Cough (Pertussis)

Critical Care Medicine

Internal Medicine

Pediatrics

Pulmonary Hypertension, Pulmonary Vascular Disease, Thromboembolic Disease.

2007 -2012 Assistant Professor, Pulmonary and Critical Care Medicine Attending, Director Pulmonary Hypertension Program, University Internal Medicine Associates Employer, University of Cincinnati, Cincinnati, OH

2002 -2003 Assistant Professor, Internal Medicine and Pediatrics Attending, Co-Director Internal Medicine Residency Program, St. Louis University, St. Louis, Missouri

2001 -2002 Instructor, Internal Medicine Chief Resident, St. Louis University, St. Louis, Missouri

2012 -To Present Associate Professor, Pulmonary and Critical Care Medicine Attending, Director Pulmonary Hypertension Program, University of Cincinnati / University Cincinnati Physicians Employer, University of Cincinnati, Cincinnati, OH

2007 -2008 University of Cincinnati Rhen Family Research Award Lymphangioleiomyomatosis Associated Pulmonary Vascular Disease and Exercise Induced Pulmonary Hypertension Role:PI

2007 -2008 ALTUS Pharmaceuticals, Inc. A Phase 3, Randomized, Double-Blind, Placebo Controlled Clinical Study Evaluating the Efficacy and Safety of ALTU-135 Treatment inPatients with CF Related Exocrine Pancreatic Insufficiency Role:Co-I

2007 -2008 ALTUS Pharmaceuticals, Inc. An Open-Label Clinical Study Evaluating the Long-Term Safety of ALTU-135 for the Treatment of Patients with CF-Related Exocrine Pancreatic Insufficiency Role:Clinical Co-I

2007 AIRES-3 A Phase 3, Long Term, Open-label, Multi-center Safety and Efficacy Study of Ambrisentan in Subjects with Pulmonary Hypertension Role:PI

Investigators:F McCormack, D Franz, J Bissler, J Elwing 2003 -2004 Rapamycin Therapy of Renal Angiomyolipomas in TSC and LAM The focus of this clinical research was to evaluate the effect of rapamycin on angiomyolipoma is in patients with TSC and LAM Role:Co-I

Grant: #109363 / R24HK1052333 Investigators:Elwing, Jean 03-03-2012 -02-28-2017 National Heart, Lung and Blood Institute National Biological Sample and Data Repository for PAH Role:PI $38,345.57 Active Level:Federal

Grant: #Covance 8455619 / OT2HL156812 Investigators:Elwing, Jean 05-01-2021 -04-30-2022 Covance ACTIV-4c Role:PI 51000.00 Awarded Level:Industry

Grant: #RVT-1201-2002 Investigators:Elwing, Jean 01-31-2022 -01-30-2025 Altavant Sciences, Inc A Phase 2b, Dose-Ranging, Randomized, Double-Blind, Placebo Controlled, Multicenter Study of Rodatristat Ethyl in Patients with Pulmonary Arterial Hypertension... Role:PI 0.00 Hold Level:Industry

Investigators:Elwing, Jean 01-28-2022 -01-27-2025 PPD A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy in Newly Diagnosed Intermediate... Role:PI 0.00 Hold Level:Industry

Grant: #Protocol A011-14 Investigators:Elwing, Jean 03-01-2022 -02-28-2025 Acceleron Pharma Inc. A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Sotatercept When Added to Maximum Tolerated Background Therapy in Participants Role:PI 336521.42 Hold Level:Industry

Grant: #A011-12 (SOTERIA) Investigators:Elwing, Jean 03-01-2022 -02-28-2025 Acceleron Pharma Inc. An Open-Label Long-term Follow-up Study to Evaluate the Effects of Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for theTreatment of PAH Role:PI 642730.45 Hold Level:Industry

Grant: #67896062PAH4005 Investigators:Elwing, Jean 10-04-2021 -10-04-2024 Actelion Pharmaceuticals US, Inc AN INTERNATIONAL, NON-DRUG INTERVENTIONAL, REAL-WORLD COHORT OF PAH PATIENTS NEWLY INITIATING PAH THERAPY WITH GUIDELINEDIRECTED ASSESSMENTS OF DISEASE SEVERITY... Role:PI 433667.53 Hold Level:Industry

Investigators:Elwing, Jean 04-01-2022 -03-31-2025 IQVIA Biotech IMPAHCT: A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 24-Week Dose Ranging and Confirmatory Study to Evaluate the Safety and Efficacy of AV-101 in Patients with Pulmonary Arterial Hyper Role:PI 413741.42 Hold Level:Industry

Investigators:Elwing, Jean 04-01-2022 -03-31-2025 Aerovate Therapeutics, Inc. IMPAHCT: A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 24-Week Dose Ranging and Confirmatory Study to Evaluate the Safety and Efficacy of AV-101 in Patients with Pulmonary Arterial Hyper Role:PI 413741.42 Hold Level:Industry

Investigators:Elwing, Jean 06-16-2023 -06-15-2026 Aerovate Therapeutics, Inc. IMPAHCT-FUL: A Long-Term Extension, Multi-Center Safety Study of AV-101 in Subjects With Pulmonary Arterial Hypertension (PAH) Who Have Completed Study AV-101-002 Role:PI 0.00 Hold Level:Industry

Grant: #PBI L606p3 Investigators:Elwing, Jean 09-12-2023 -09-12-2026 Liquidia Technologies A Phase 3, 2-Part, Open-Label, Multicenter Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Liposomal Treprostinil Inhalation Suspension (L606) in Subjects With Pulmonar Role:PI 216362.30 Hold Level:Industry

Grant: #ARTISAN REM-PH-418 Investigators:Elwing, Jean 12-15-2023 -12-14-2026 United Therapuetics A Phase 4, Prospective, Multicenter, Single-Arm Study of a MeanPulmonary Artery Pressure-Targeted Approach with Early andRapid Treprostinil Therapy to Reverse Right VentricularRemodeling in Pati Role:PI 382760.05 Active Level:Industry

Grant: #GB002-3101 Investigators:Elwing, Jean 01-17-2024 -01-16-2027 PPD A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Inhalation of Seralutinib for the Treatment of Pulmonary Arterial Hypertension (PAH) Role:PI 283845.35 Hold Level:Industry

Grant: #KER_012_A201 Investigators:Elwing, Jean 03-07-2024 -03-06-2027 Keros Therapeutics, Inc. A Randomized, Phase 2, Double-blind, Placebo-controlled Study to Investigate the Safety and Efficacy of KER-012 in Combination with Background Therapy in Adult Participants with Pulmonary Arterial Hyp Role:PI 258300.95 Hold Level:Industry

Peer Reviewed Publications

Kelly, Stephanie J; Singhal, Shalabh; Elwing, Jean M; Shizukuda, Yukitaka (2010. ) Characteristics of exercise-induced intrapulmonary arteriovenous fistula in patients with unexplained exertional dyspnea.Echocardiography (Mount Kisco, N.Y.), , 27 (8 ) ,908-13 More Information

Kelly, Stephanie J; Singhal, Shalabh; Elwing, Jean M; Shizukuda, Yukitaka (2010. ) Characteristics of Exercise-Induced Intrapulmonary Arteriovenous Fistula in Patients with Unexplained Exertional Dyspnea.Echocardiography (Mount Kisco, N.Y.), , More Information

Knight, Jennifer; Elwing, Jean M; Milstone, Aaron (2008. ) Bronchovascular fistula formation: a rare airway complication after lung transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, , 27 (10 ) ,1179-85 More Information

Bissler, John J; McCormack, Francis X; Young, Lisa R; Elwing, Jean M; Chuck, Gail; Leonard, Jennifer M; Schmithorst, Vincent J; Laor, Tal; Brody, Alan S; Bean, Judy; Salisbury, Shelia; Franz, David N (2008. ) Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis.The New England journal of medicine, , 358 (2 ) ,140-51 More Information

Elwing, Jean; Panos, Ralph J (2008. ) Pulmonary hypertension associated with COPD. International journal of chronic obstructive pulmonary disease, , 3 (1 ) ,55-70

McGraw, Dennis W; Elwing, Jean M; Fogel, Kevin M; Wang, Wayne C H; Glinka, Clare B; Mihlbachler, Kathryn A; Rothenberg, Marc E; Liggett, Stephen B (2007. ) Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation.The Journal of clinical investigation, , 117 (5 ) ,1391-8 More Information

López-Candales, Angel; Lopez, Francisco R; Trivedi, Setu; Elwing, Jean (2014. ) Right ventricular ejection efficiency: a new echocardiographic measure of mechanical performance in chronic pulmonary hypertension.Echocardiography (Mount Kisco, N.Y.), , 31 (4 ) ,516-23 More Information

Anjak, Ahmad; López-Candales, Angel; Lopez, Francisco R; Harris, David; Elwing, Jean (2014. ) Objective measures of right ventricular function during exercise: results of a pilot study.Echocardiography (Mount Kisco, N.Y.), , 31 (4 ) ,508-15 More Information

Zafar, Muhammad A; McCormack, Francis X; Rahman, Shahid; Tencza, Christian; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Shizukuda, Yukitaka; Elwing, Jean M (2013. ) Pulmonary vascular shunts in exercise-intolerant patients with lymphangioleiomyomatosis.American journal of respiratory and critical care medicine, , 188 (9 ) ,1167-70 More Information

Kingrey, John F; Panos, Ralph J; Ying, Jun; Meganathan, Karthikeyan; Vandivier, Robin; Elwing, Jean M (2013. ) Provider recognition and response to echocardiographic findings indicating pulmonary hypertension in the Veterans affairs medical center population.Pulmonary circulation, , 3 (2 ) ,389-95 More Information

Medepalli, Kantha; Lee, Cody M; Benninger, Lauryn A; Elwing, Jean M (2016. ) Psychosis: call a surgeon? A rare etiology of psychosis requiring resection.SAGE open medical case reports, , 4 ,2050313X16670084 More Information

Maron, Bradley A; Hess, Edward; Maddox, Thomas M; Opotowsky, Alexander R; Tedford, Ryan J; Lahm, Tim; Joynt, Karen E; Kass, Daniel J; Stephens, Thomas; Stanislawski, Maggie A; Swenson, Erik R; Goldstein, Ronald H; Leopold, Jane A; Zamanian, Roham T; Elwing, Jean M; Plomondon, Mary E; Grunwald, Gary K; Barón, Anna E; Rumsfeld, John S; Choudhary, Gaurav (2016. ) Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program.Circulation, , 133 (13 ) ,1240-8 More Information

Lee, Cody M; Girnita, Diana; Sharma, Arundhati; Khanna, Surabhi; Elwing, Jean M (2016. ) A Unique Presentation of Anti-RNA Polymerase III Positive Systemic Sclerosis Sine Scleroderma.Case reports in rheumatology, , 2016 ,8536341 More Information

Lee, Cody; Elwing, Jean (2017. ) Pulse dose steroids in severe pulmonary arterial hypertension secondary to systemic lupus erythematosus.SAGE open medical case reports, , 5 ,2050313X17707153 More Information

Rahaghi, Franck F; Feldman, Jeremy P; Allen, Roblee P; Tapson, Victor; Safdar, Zeenat; Balasubramanian, Vijay P; Shapiro, Shelley; Mathier, Michael A; Elwing, Jean M; Chakinala, Murali M; White, R James (2017. ) Recommendations for the use of oral treprostinil in clinical practice: a Delphi consensus project pulmonary circulation.Pulmonary circulation, , 7 (1 ) ,167-174 More Information

Rhodes, Christopher J; Batai, Ken; Bleda, Marta; Haimel, Matthias; Southgate, Laura; Germain, Marine; Pauciulo, Michael W; Hadinnapola, Charaka; Aman, Jurjan; Girerd, Barbara; Arora, Amit; Knight, Jo; Hanscombe, Ken B; Karnes, Jason H; Kaakinen, Marika; Gall, Henning; Ulrich, Anna; Harbaum, Lars; Cebola, Inês; Ferrer, Jorge; Lutz, Katie; Swietlik, Emilia M; Ahmad, Ferhaan; Amouyel, Philippe; Archer, Stephen L; Argula, Rahul; Austin, Eric D; Badesch, David; Bakshi, Sahil; Barnett, Christopher; Benza, Raymond; Bhatt, Nitin; Bogaard, Harm J; Burger, Charles D; Chakinala, Murali; Church, Colin; Coghlan, John G; Condliffe, Robin; Corris, Paul A; Danesino, Cesare; Debette, Stéphanie; Elliott, C Gregory; Elwing, Jean; Eyries, Melanie; Fortin, Terry; Franke, Andre; Frantz, Robert P; Frost, Adaani; Garcia, Joe G N; Ghio, Stefano; Ghofrani, Hossein-Ardeschir; Gibbs, J Simon R; Harley, John; He, Hua; Hill, Nicholas S; Hirsch, Russel; Houweling, Arjan C; Howard, Luke S; Ivy, Dunbar; Kiely, David G; Klinger, James; Kovacs, Gabor; Lahm, Tim; Laudes, Matthias; Machado, Rajiv D; MacKenzie Ross, Robert V; Marsolo, Keith; Martin, Lisa J; Moledina, Shahin; Montani, David; Nathan, Steven D; Newnham, Michael; Olschewski, Andrea; Olschewski, Horst; Oudiz, Ronald J; Ouwehand, Willem H; Peacock, Andrew J; Pepke-Zaba, Joanna; Rehman, Zia; Robbins, Ivan; Roden, Dan M; Rosenzweig, Erika B; Saydain, Ghulam; Scelsi, Laura; Schilz, Robert; Seeger, Werner; Shaffer, Christian M; Simms, Robert W; Simon, Marc; Sitbon, Olivier; Suntharalingam, Jay; Tang, Haiyang; Tchourbanov, Alexander Y; Thenappan, Thenappan; Torres, Fernando; Toshner, Mark R; Treacy, Carmen M; Vonk Noordegraaf, Anton; Waisfisz, Quinten; Walsworth, Anna K; Walter, Robert E; Wharton, John; White, R James; Wilt, Jeffrey; Wort, Stephen J; Yung, Delphine; Lawrie, Allan; Humbert, Marc; Soubrier, Florent; Trégouët, David-Alexandre; Prokopenko, Inga; Kittles, Richard; Gräf, Stefan; Nichols, William C; Trembath, Richard C; Desai, Ankit A; Morrell, Nicholas W; Wilkins, Martin R (2019. ) Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.The Lancet. Respiratory medicine, , 7 (3 ) ,227-238 More Information

Elwing, Jean M; Vaidya, Anjali; Auger, William R (2018. ) Chronic Thromboembolic Pulmonary Hypertension: An Update.Clinics in chest medicine, , 39 (3 ) ,605-620 More Information

DesJardin, Jacqueline T; Kolaitis, Nicholas A; Kime, Noah; Kronmal, Richard A; Benza, Raymond L; Elwing, Jean M; Lammi, Matthew R; McConnell, John W; Presberg, Kenneth W; Sager, Jeffrey S; Shlobin, Oksana A; De Marco, Teresa (2020. ) Age-related differences in hemodynamics and functional status in pulmonary arterial hypertension: Baseline results from the Pulmonary Hypertension Association Registry.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, , More Information

Jose, Arun; Kher, Akhil; O'Donnell, Robert E; Elwing, Jean M (2020. ) Cardiac magnetic resonance imaging as a prognostic biomarker in treatment-naïve pulmonary hypertension.European journal of radiology, , 123 ,108784 More Information

Jose, Arun; Eckman, Mark H; Elwing, Jean M Anticoagulation in pulmonary arterial hypertension: a decision analysis.Pulmonary circulation, , 9 (4 ) ,2045894019895451 More Information

Vick, Eric; Sharma, Divya; Elwing, Jean (2019. ) Raynaud Phenomenon in Antisynthetase Syndrome Treated With Epoprostenol.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, , More Information

Zhu, Na; Pauciulo, Michael W; Welch, Carrie L; Lutz, Katie A; Coleman, Anna W; Gonzaga-Jauregui, Claudia; Wang, Jiayao; Grimes, Joseph M; Martin, Lisa J; He, Hua ; Shen, Yufeng; Chung, Wendy K; Nichols, William C (2019. ) Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension.Genome medicine, , 11 (1 ) ,69 More Information

2007 Rhen Family Research Award

2006 2nd Place Pulmonary Fellows Jopardy, Ohio Thoracic Society

2003 Osler Ward for Outstanding Teaching Attending

2003 Letter of Commendation St. Louis Med Staff, Development of a Central Venous Access Course

2001 Kinella Memorial Award for Best Graduating Resident

2001 Best Teaching Resident Voted by Medical Students

pulmonary hypertension, pulmonary vascular disease, thromboembolic disease

Academic - Medical Sciences Building
231 Albert Sabin Way, ML 0564
Cincinnati  Ohio, 45267
Phone: 513-558-4831
Fax: 513-558-4858
jean.elwing@uc.edu

Practice - Holmes
200 Albert Sabin Way, 3rd Floor
Cincinnati  Ohio, 45219
Phone: 513-475-8523
Fax: 5134757327
jean.elwing@uc.edu