Tolly E G Epstein, MD

Bachelor's Degree: Indiana University 1998 (Biology & Spanish (English Minor))

Medical Degree: Indiana University School of Medicine 2003

Master's Degree: University of Cincinnati College of Medicine 2010 (Clinical Research/Molecular Epidemiology)

Resident : Barnes-Jewish Hospital/Washington University 2006 (Internal Medicine )

Fellowship : University of Cincinnati College of Medicine 2010 (Allergy & Immunology )

American Board of Allergy and Immunology (Certification Date: 10-08-2010 )

American Board of Internal Medicine (Certification Date: 09-01-2006 )

Research interests:  Allergen immunotherapy, Asthma in Older Adults, Impact of Air pollutants on Asthma and Allergic Diseases

Practice interests:   A wide range of allergic disorders including asthma, rhinitis, food allergy, hives/angioedema, and contact dermatitis, as well as immunologic disorders including immune deficiencies

2010 -To Present Assistant Professor, Division of Allergy, Immunology, & Rheumatology, University of Cincinnati, Cincinnati, OH

2010 -To Present Attending Physician, Allergy & Immunology, Cincinnati VA Medical Center, Cincinnati, OH

2006 -2007 Hospitalist Attending, Barnes-Jewish Hospital, St. Louis, MO

1998 -1999 V.I.S.T.A. (Volunteers in Service to America) Coordinator of America Reads Literacy Programs, Pueblo Family Center, Pueblo, CO

1998 - Clinical Research Assistant, Allergy, Asthma, & Clinical Immunology Associates, Indianapolis, IN

Grant: #1008820 04-01-2011 -03-31-2013 University of Cincinnati KL2 Grant Program Air Pollutants, Anti-Oxidant Genes, and Asthma Severity in Older Adults Role:PI $140,672

04-2010 -03-2011 University of Cincinnati Center for Environmental Genetics Pilot Projects Program Grant Air Pollutants, Anti-Oxidant Genes, and Asthma Severity in Older Adults Role:PI

01-2010 -01-2011 University of Cincinnati Center for Environmental Genetics New Investigator Scholars Grant Air Pollutants, Anti-Oxidant Genes, and Asthma Severity in Older Adults

12-2008 -12-2009 University of Cincinnati/Cincinnati Children's Hospital Center for Environmental Genetics New Investigator Scholars Grant SPRR2B Polymorphisms and Eczema

07-2008 -07-2010 University of Cincinnati - Cincinnati Childhood Asthma & Air Pollution Study Atopic Dermatitis and Environmental Exposures

Grant: #OHHHU0027-14 Investigators:Epstein, Tolly; Grinshpun, Sergey; Reponen, Tiina 11-28-2014 -11-30-2017 Department of Housing and Urban Development Efficiency of HEPA air purification in reducing traffic-related particle exposures Role:Collaborator $688,261.00 Awarded Level:Federal

Peer Reviewed Publications

Epstein, Tolly; Bernstein, David I  (2026). Immunotherapy in Allergic and Mixed Rhinitis. Immunology and allergy clinics of North America, 46 (1) , 111-124More Information

Epstein, Tolly G; Berendts, Karen; Bernstein, David I  (2026). Impact of Dose Adjustment After Gaps in Subcutaneous Immunotherapy: Update From the North American Immunotherapy Surveillance Study (2008-2023). The journal of allergy and clinical immunology. In practice, 14 (1) , 253-259.e2More Information

Epstein, Tolly E G; Rorie, Andrew C; Ramon, German D; Keswani, Anjeni; Bernstein, Jonathan; Codina, Rosa; Codispoti, Christopher; Craig, Timothy; Dykewicz, Mark; Ferastraoaru, Denisa; Katz, Daniel; Kim, Jean; Larenas-Linnemann, Désirée; Nanda, Anil; Nguyen, Anh; Anand, Mahesh Padukudru; Patterson, Amber; Ponda, Punita; Toskala, Elina; Wasan, Anita N  (2025). Impact of climate change on aerobiology, rhinitis, and allergen immunotherapy: Work Group Report from the Aerobiology, Rhinitis, Rhinosinusitis & Ocular Allergy, and Immunotherapy, Allergen Standardization & Allergy Diagnostics Committees of the American Academy of Allergy, Asthma & Immunology. The Journal of allergy and clinical immunology, 155 (6) , 1767-1782.e2More Information

Bernstein, David I; Khan, Najeeb; Epstein, Tolly G  (2023). Reply to "Does hydroxychloroquine work for chronic spontaneous urticaria?". The journal of allergy and clinical immunology. In practice, 11 (6) , 1983-1984More Information

Larenas-Linnemann, Désirée; Ponda, Punita; Creticos, Peter; Bernstein, David; Epstein, Tolly; Williams, Paul  (2023). Dose Adjustment After Gaps in Administration of Subcutaneous Immunotherapy From a Past Survey: Work Group Report of the AAAAI Allergen Standardization and Allergy Diagnostics Committee. The journal of allergy and clinical immunology. In practice, 11 (1) , 145-148.e4More Information

Epstein, Tolly E G; Calabria, Christopher W  (2022). Is immunotherapy safe for treatment of severe asthma. Current opinion in allergy and clinical immunology, 22 (6) , 396-401More Information

Khan, Najeeb; Epstein, Tolly G; DuBuske, Ilona; Strobel, Maria; Bernstein, David I  (2022). Effectiveness of Hydroxychloroquine and Omalizumab in Chronic Spontaneous Urticaria: A Real-World Study. The journal of allergy and clinical immunology. In practice, 10 (12) , 3300-3305More Information

Chow, Timothy G; Palka, Jayme M; Stone, Brian; Trojan, Timothy; Epstein, Tolly G; Khan, David A  (2022). Safety of subcutaneous immunotherapy in patients with severe asthma. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 129 (5) , 585-591.e3More Information

Bernstein, David I; Epstein, Tolly G  (2022). Managing risk of anaphylaxis in patients receiving allergen immunotherapy: Assessing benefit versus risk. The Journal of allergy and clinical immunology, 149 (3) , 884-886More Information

Dhamija, Yashu; Epstein, Tolly E G; Bernstein, David I  (2022). Systemic Allergic Reactions and Anaphylaxis Associated with Allergen Immunotherapy. Immunology and allergy clinics of North America, 42 (1) , 105-119More Information

Epstein, Tolly G; Murphy-Berendts, Karen; Liss, Gary M; Bernstein, David I  (2021). Risk factors for fatal and nonfatal reactions to immunotherapy (2008-2018): postinjection monitoring and severe asthma. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 127 (1) , 64-69.e1More Information

Larenas-Linnemann, Désirée Erlinda; Epstein, Tolly; Ponda, Punita; Bernstein, David; Williams, Paul; Creticos, Peter  (2020). Gaps in allergen immunotherapy administration and subcutaneous allergen immunotherapy dose adjustment schedules: Need for prospective data. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 125 (5) , 505-506.e2More Information

Epstein, Tolly G; Liss, Gary M; Berendts, Karen Murphy; Bernstein, David I  (2019). AAAAI/ACAAI Subcutaneous Immunotherapy Surveillance Study (2013-2017): Fatalities, Infections, Delayed Reactions, and Use of Epinephrine Autoinjectors. The journal of allergy and clinical immunology. In practice, 7 (6) , 1996-2003.e1More Information

Epstein, Tolly E; Tankersley, Mike S  (2017). Are Allergen Immunotherapy Dose Adjustments Needed for Local Reactions, Peaks of Season, or Gaps in Treatment?. The journal of allergy and clinical immunology. In practice, 5 (5) , 1227-1233More Information

Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I  (2017). Evaluation of the risk of infection associated with subcutaneous allergen immunotherapy: American Academy of Allergy, Asthma, and Immunology and American College of Allergy, Asthma, and Immunology National Surveillance Study on Allergen Immunotherapy, 2014-2015. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 118 (4) , 511-512More Information

Epstein, Tolly G; Calabria, Christopher; Cox, Linda S; Dreborg, Sten  (2017). Current Evidence on Safety and Practical Considerations for Administration of Sublingual Allergen Immunotherapy (SLIT) in the United States. The journal of allergy and clinical immunology. In practice, 5 (1) , 34-40.e2More Information

Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I  (2016). Risk factors for fatal and nonfatal reactions to subcutaneous immunotherapy: National surveillance study on allergen immunotherapy (2008-2013). Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 116 (4) , 354-359.e2More Information

Davis, Benjamin P; Epstein, Tolly; Kottyan, Leah; Amin, Priyal; Martin, Lisa J; Maddox, Avery; Collins, Margaret H; Sherrill, Joseph D; Abonia, J Pablo; Rothenberg, Marc E  (2016). Association of eosinophilic esophagitis and hypertrophic cardiomyopathy. The Journal of allergy and clinical immunology, 137 (3) , 934-6.e5More Information

Kannan, Jennifer A; Bernstein, David I; Bernstein, Cheryl K; Ryan, Patrick H; Bernstein, Jonathan A; Villareal, Manuel S; Smith, Andrew M; Lenz, Peter H; Epstein, Tolly G  (2015). Significant predictors of poor quality of life in older asthmatics. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 115 (3) , 198-204More Information

Amin, Priyal; Levin, Linda; Epstein, Tolly; Ryan, Pat; LeMasters, Grace; Khurana Hershey, Gurjit; Reponen, Tina; Villareal, Manuel; Lockey, James; Bernstein, David I  (2014). Optimum predictors of childhood asthma: persistent wheeze or the Asthma Predictive Index?. The journal of allergy and clinical immunology. In practice, 2 (6) , 709-15More Information

Cheng, G; Smith, A M; Levin, L; Epstein, T; Ryan, P H; LeMasters, G K; Khurana Hershey, G K; Reponen, T; Villareal, M; Lockey, J; Bernstein, D I  (2014). Duration of day care attendance during infancy predicts asthma at the age of seven: the Cincinnati Childhood Allergy and Air Pollution Study. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44 (10) , 1274-81More Information

Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I  (2014). AAAAI/ACAAI surveillance study of subcutaneous immunotherapy, years 2008-2012: an update on fatal and nonfatal systemic allergic reactions. The journal of allergy and clinical immunology. In practice, 2 (2) , 161-7More Information

Epstein, Tolly G; Kesavalu, Banurekha; Bernstein, Cheryl K; Ryan, Patrick H; Bernstein, Jonathan A; Zimmermann, Nives; Lummus, Zana; Villareal, Manuel S; Smith, Andrew M; Lenz, Peter H; Bernstein, David I  (2013). Chronic traffic pollution exposure is associated with eosinophilic, but not neutrophilic inflammation in older adult asthmatics. The Journal of asthma : official journal of the Association for the Care of Asthma, 50 (9) , 983-9More Information

Kannan, Jennifer A; Epstein, Tolly G  (2013). Immunotherapy safety: what have we learned from surveillance surveys?. Current allergy and asthma reports, 13 (4) , 381-8More Information

Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I  (2013). AAAAI and ACAAI surveillance study of subcutaneous immunotherapy, Year 3: what practices modify the risk of systemic reactions?. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110 (4) , 274-8, 278.e1More Information

Epstein, Tolly G; Ryan, Patrick H; LeMasters, Grace K; Bernstein, Cheryl K; Levin, Linda S; Bernstein, Jonathan A; Villareal, Manuel S; Bernstein, David I  (2012). Poor asthma control and exposure to traffic pollutants and obesity in older adults. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 108 (6) , 423-428.e2More Information

Epstein, Tolly G; LeMasters, Grace K; Bernstein, David I; Ericksen, Mark B; Martin, Lisa J; Ryan, Patrick H; Biagini Myers, Jocelyn M; Butsch Kovacic, Melinda S; Lindsey, Mark A; He, Hua; Reponen, Tiina; Villareal, Manuel S; Lockey, James E; Bernstein, Cheryl K; Khurana Hershey, Gurjit K  (2012). Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 108 (3) , 145-50More Information

Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I  (2011). Immediate and delayed-onset systemic reactions after subcutaneous immunotherapy injections: ACAAI/AAAAI surveillance study of subcutaneous immunotherapy: year 2. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 107 (5) , 426-431.e1More Information

Bernstein, David I; Epstein, Tolly  (2011). Systemic reactions to subcutaneous allergen immunotherapy. Immunology and allergy clinics of North America, 31 (2) , 241-9, viii-ixMore Information

Epstein, Tolly G; Bernstein, David I; Levin, Linda; Khurana Hershey, Gurjit K; Ryan, Patrick H; Reponen, Tiina; Villareal, Manuel; Lockey, James E; Lemasters, Grace K  (2011). Opposing effects of cat and dog ownership and allergic sensitization on eczema in an atopic birth cohort. The Journal of pediatrics, 158 (2) , 265-71.e1-5More Information

Bernstein, David I; Epstein, Tolly; Murphy-Berendts, Karen; Liss, Gary M  (2010). Surveillance of systemic reactions to subcutaneous immunotherapy injections: year 1 outcomes of the ACAAI and AAAAI collaborative study. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 104 (6) , 530-5More Information

Biagini Myers, Jocelyn M; Wang, Ning; LeMasters, Grace K; Bernstein, David I; Epstein, Tolly G; Lindsey, Mark A; Ericksen, Mark B; Chakraborty, Ranajit; Ryan, Patrick H; Villareal, Manuel S; Burkle, Jeff W; Lockey, James E; Reponen, Tiina; Khurana Hershey, Gurjit K  (2010). Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort. The Journal of investigative dermatology, 130 (2) , 430-7More Information

Epstein, Tolly G; Bernstein, Jonathan A  (2008). Current and emerging management options for hereditary angioedema in the US. Drugs, 68 (18) , 2561-73More Information

2010 Featured Research Poster American Academy of Allergy, Asthma, & Immunology

2009 First Place, Internal Medicine Trainee's Research Grand Rounds

2006 Elected Teaching Resident

1999 -2000 Mariellen Dentino Scholarship (for outstanding academic performance)

1998 Graduated with Highest Distinction (Top 3% in Biological Sciences & Arts)

1998 Phi Beta Kappa

1996 Golden Key Honor Society

1995 Phi Eta Sigma

1995 -1998 Dean's List

Allergy

Academic - Health Professions Building
3255 Eden Avenue
Cincinnati  Ohio, 45267
Phone: 513) 558-4701
Fax: (513) 558-3799
epsteite@ucmail.uc.edu