Engineering Research Cntr
CEAS - Elec Eng & Computer Science - 0030
Dr. Esfandiari joined the College of Engineering and Applied Science at the University of Cincinnati as an Assistant Professor with dual appointment in Electrical Engineering and Biomedical Engineering. She completed her doctoral degree in Bioengineering from the University of California Los Angeles (UCLA). She earned her Master of Science in Biomedical Engineering from the University of California Irvine with focus on design and development of a microfluidic platform for studying neurogenesis. Also, she obtained her Bachelor of Science in Electrical Engineering from California State University.
While at UCLA, Esfandiari also conducted research for the California Nano-System Institution (CNSI), and the Orthopedic Surgery Laboratory. During her academic training, Esfandiari has spent time giving back by leading and training graduate and undergraduate students in conducting research and experiments. Besides her academic practice, she has 4 years of industrial experience at Applied Medical Co and Honeywell Inc.
Dr. Esfandiari has a multidisciplinary research background in development of Microelectromechanical Systems (MEMS) for studying cell mechanics, nano-surface chemistry and development of molecular biosensors. At University of Cincinnati, she is leading the Integrative BioSensing Laboratory with the main focus on design and development of miniaturized biosensors and bio-platforms for point-of-care (POC) medical diagnostics, preventive and therapeutic medicine.
Ph.D., University of California Los Angeles (UCLA) Los Angeles CA, 2014 (Bioengineering )
MS.c. , University of California Irvine (UCI) Irvine CA, 2008 (Biomedical Engineering )
B.S, California State University Long Beach CA, 2006 (Electrical Engineering )
Rapid, sensitive, portable and robust detection of biomolecules is of significant interest in a range of diverse health-related applications such as screening for oncogenes in cancer, drug screening in pharmaceutical industry, pathogen microbe identification in food and water safety, paternity test in forensic science and detection of bio-warfare agent in homeland security. However, the majority of the conventional detection methods are relying on tedious sample preparation techniques, target amplification by polymerase chain reaction (PCR), enzyme and fluorescent labeling, or sophisticated/bulky instrumentation. To address these shortcomings, Esfandiari’s research group is utilizing nanotechnology and microfabrication techniques to develop reagent-free handheld and wearable diagnostic devices with high sensitivity, selectivity and stable shelf life.
Additionally, she is interested in design and implementation of bio-platforms for investigating the effect of quantitatively controlled applied cues on various cell types to study the cell signaling pathways. Studying the micron-scale biological units under controlled heterogeneous environmental cues is crucial for understanding tissue functions and ultimately the organ system. The systematic investigation of basic biology under controlled applied forces has potential application in preventive, therapeutic, and regenerative medicine.
Grant: #ODOT 27834 Investigators:Esfandiari, Leyla; Helmicki, Arthur; Hunt, Victor; Wendell, David 10-07-2016 -04-07-2017 Federal Highway Administration Noninvasive method to detect Eastern Hellbender in the state of Ohio using the environmental DNA Role:PI $98,541.11 Active Level:Federal
Grant: #30792 (FHWA), Hellbender Phase II Investigators:Esfandiari, Leyla; Wendell, David 03-20-2018 -03-20-2021 Ohio Department of Transportation Phase II: Non-Invasive Detection and Identification of Eastern Hellbender in Ohio Surface Waters Using Aquatic Environmental DNA Role:Collaborator $659,659.69 Active Level:State of Ohio
Grant: #URS Strategic Collaborative Grants AY2017-2018 Investigators:Esfandiari, Leyla 07-30-2015 -06-30-2017 UC's Research Support Non-invasive biosensing through skin: Integrated reverse iontophoresis extraction and electrochemical impendance spectroscopy detection Role:PI $125,000.00 Active Level:Internal UC
Grant: #307985_1R21CA240664-01 Investigators:Esfandiari, Leyla 07-01-2019 -06-30-2021 National Institutes of Health Detection and characterization of cell type-specific extracellular vesicles in obesity-driven hepatocellular carcinoma Role:PI $56,635.00 Active Level:Federal
Peer Reviewed Publications
Esfandiari L.; Huang T.; Kaynak A.; Zhang Y. (04-19-2019. ).Analytical and Bioanalytical Chemistry, ,411 (10 ),1935-1941
Esfandiari L.; Rana A.; Shi L. (12-01-2018. ).Scientific Reports, ,8 (1 ),
Esfandiari L.; Rana A.; Zhang Y. (07-07-2018. ).Analyst, ,143 (13 ),2971-2991
Czyzyk-Krzeska M.; Esfandiari L.; Rana A.; Stratton Y.; Zhang Y. (09-05-2017. ).Analytical Chemistry, ,89 (17 ),9201-9208
Boyce S.; Brooks T.; Esfandiari L.; Heikenfeld J.; Kasting G.; Park Y.; Ventura S. (04-01-2017. ).Bioelectrochemistry, ,114 ,54-60
Esfandiari L.; Zhang Y. (11-21-2016. ).16th International Conference on Nanotechnology - IEEE NANO 2016, ,293-296
Esfahani E.; Esfandiari L.; Ghobadi M.; Rana A.; Zhang Y. (10-13-2016. ).Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, ,2016-October ,4228-4231
Banda A.; Esfandiari L.; Kocharyan G.; Lorenzini M.; Monbouquette H.; Schmidt J.; Wang S. (01-01-2016. ).Biosensors, ,6 (3 ),
Esfandiari L.; Kocharyan G.; Lorenzini M.; Monbouquette H.; Schmidt J. (10-07-2014. ).Analytical Chemistry, ,86 (19 ),9638-9643
Esfandiari L.; Monbouquette H.; Schmidt J. (09-26-2012. ).Journal of the American Chemical Society, ,134 (38 ),15880-15886
Esfandiari L.; Paff M.; Tang W. (05-01-2012. ).Nanomedicine: Nanotechnology, Biology, and Medicine, ,8 (4 ),415-418
Esfandiari L.; Tang W. (12-01-2010. ).2010 IEEE International Conference on Nano/Molecular Medicine and Engineering, IEEE NANOMED 2010, ,26-29