Guo-Chang Fan

Guo-Chang Fan

Professor

Cardiovascular Rsrch Cntr

5923

COM PCB Fan Lab - 0575

Cardiovascular Center Building
Room 5923
Cincinnati, Ohio 45267-0575

Professional Summary

Guo-Chang Fan, PhD
Professor
Department of Pharmacology and Cell Biophysics
University of Cincinnati College of Medicine
231 Albert Sabin Way
Cincinnati, OH, 45267-0575
Tel: 513-558-2340
Office: CVC #5923
Lab: CARE#5872, #5881

Research Summary:

Fan laboratory is dedicated to performing cardiovascular research that involves:  1) dissecting the molecular/cellular mechanisms underlying ischemia/reperfusion-induced cardiac remodeling; 2) elucidating how infection/inflammation (i.e., sepsis) causes vascular leakage and heart failure; and 3) defining the role of macrophages in disease-induced cardiovascular dysfunction. Fan lab primarily uses in vivo transgenic and knockout animal models as well as in vitro primary cell culture.  In addition, multiple state-of-art techniques (i.e., CRISPR-Cas9, single-cell sequencing, RNA sequencing, cell sorting, flow cytometry, Co-IP, Co-immunostaining, and bioinformatics) are employed to analyze the molecular/cellular mechanisms. 

Notably, his research team was the first to show that miRNAs were involved in the ischemia/reperfusion (I/R)-induced cardiovascular damage (Circulation, 2009 & 2010; J Biol Chem., 2016 & 2019).  Recent years, Dr. Fan have pioneered a new research direction toward understanding the roles of exosomes and macrophages in cardiovascular patho-physiology (Diabetes, 2016; Shock, 2020; Cells, 2020; J Immunol., 2020).  Because of his outstanding achievement in the field of exosome/miRNA research, Dr. Fan was awarded “Established Investigator” by American Heart Association in 2016. Currently, Dr. Fan serves as editorial board member for multiple academic journals (i.e., Shock, Cells, Scientific Reports, Biology), and grant proposal reviewer for NIH and AHA.
 

Education

Doctoral Degree, Zhejiang University 1998 (Molecular Cell Biology)

Master's Degree, Chinese Academy of Sciences 1995 (Microbiology)

Bachelor's Degree, Nanjing Normal University 1993 (Biology)

Positions and Work Experience

01-01-2006 -12-30-2008 Research Instructor, Dept. of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH

01-01-2009 -09-30-2009 Research Assistant Professor, University of Cincinnati College of Medicine, Cincinnati, OH

10-01-2009 -06-01-2014 Assistant Professor , University of Cincinnati College of Medicine, Cincinnati, OH

06-01-2014 - Associate Professor, University of Cincinnati College of Medicine,

09-01-2018 - Professor, Department of Pharmacology and Systems Physiology, , University of Cincinnati College of Medicine, Cincinnati, OH

Research and Practice Interests

Fan laboratory is dedicated to performing cardiovascular research that involves:  1) dissecting the molecular/cellular mechanisms underlying ischemia/reperfusion-induced cardiac remodeling; 2) elucidating how infection/inflammation (i.e., sepsis) causes vascular leakage and heart failure; and 3) defining the role of macrophages in disease-triggered cardiovascular dysfunction. 

Research Support

Grant: #R01 GM112930 Investigators:Guochang Fan 12-01-2014 -11-30-2019 NIH Duplex miR-223 and Exosomes in Sepsis Role:PI $1,250,000 Pending Type:Grant Level:National

Grant: #R01 HL087861 Investigators:Fan, Guochang 04-18-2007 -01-31-2013 National Heart, Lung and Blood Institute Physiological and Pathophysiological Roles of Hsp20 in the Heart Role:PI $1,950,000.00 Closed Level:Federal

Grant: #3 R01 HL087861-03S1 Investigators:Fan, Guochang 07-01-2009 -06-30-2011 National Heart, Lung and Blood Institute Physiological and Pathophysiological Roles of Hsp20 in the Heart Role:PI $267,314.00 Closed Level:Federal

Grant: #R01HL087861 Investigators:Fan, Guochang; Narmoneva, Daria 07-01-2013 -06-30-2018 National Heart, Lung and Blood Institute Roles of Hsp20-Exosomes in Myocardial Angiogenesis Role:PI $393,270.00 Active Level:Federal

Grant: #AHA 0730076N Investigators: Fan, Guochang 01-01-2007 -04-15-2007 American Heart Association - National Chapter Cardioprotection of Hsp20 and Its Mechanisms Role:PI $65,000.00

Grant: #1 R01 GM112930 Investigators:Caldwell, Charles; Fan, Guochang 01-01-2015 -12-31-2018 National Institute of General Medical Sciences Duplex miR-223 and Exosomes in Sepsis Role:PI $307,928.00 Awarded Level:Federal

Grant: #17EIA33400063 Investigators:Fan, Guochang 01-01-2017 -12-31-2021 American Heart Association - National Chapter Exosomes and Their Content Reprogramming in Heart Failure Role:PI $80,000.00 Active Level:Private Non-Profit

Grant: #R01GM126061 Investigators:Fan, Guochang 12-10-2017 -11-30-2021 National Institute of General Medical Sciences Tsg101 and endosomes in cardiac surgery-induced injury Role:PI $303,446.00 Awarded Level:Federal

Grant: #18PRE33960576 Investigators:Fan, Guochang; Li, Yutian 07-01-2018 -06-30-2020 American Heart Association - National Chapter Role of Sectm1a in Diabetes-Induced Cardiac Dysfunction Role:Collaborator $53,688.00 Active Level:Private Non-Profit

Grant: #18PRE34030123 Investigators:Essandoh, Kobina; Fan, Guochang 07-01-2018 -06-30-2020 American Heart Association - National Chapter Role of Tsg101 in endosomal translocation of Glut-4 in ischemic hearts Role:Collaborator $53,688.00 Active Level:Private Non-Profit

Grant: #R01 HL143490 Investigators:Fan, Guochang; Rubinstein, Jack; Sadayappan, Sakthivel; Wang, Yi-Gang; Xu, Meifeng 04-01-2019 -03-31-2023 National Institute of Allergy and Infectious Diseases IGF-2R is a new therapeutic target for cardiac ischemia-reperfusion injury Role:Collaborator $411,432.00 Awarded Level:Federal

Grant: #R01-GM-132149 Investigators:Caldwell, Charles; Fan, Guochang 04-01-2019 -03-31-2023 National Institutes of Health Roles of Sectm1a in macrophages and cardiac function during sepsis Role:PI $304,713.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Mu, Xingjiang; Wang, Xiaohong; Huang, Wei; Wang, Rui-Tao; Essandoh, Kobina; Li, Yutian; Pugh, Amanda M; Peng, Jiangtong; Deng, Shan; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Yu, Kai-Jiang; Fan, Guo-Chang (2017. )Circulating Exosomes Isolated from Septic Mice Induce Cardiovascular Hyperpermeability Through Promoting Podosome Cluster Formation.Shock (Augusta, Ga.), ,

Li, Shengcun; Zhang, Lulu; Ni, Rui; Cao, Ting; Zheng, Dong; Xiong, Sidong; Greer, Peter A; Fan, Guo-Chang; Peng, Tianqing (2016. )Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress.Biochimica et biophysica acta, ,1862 (11 ),2023-2033

Wang, Xiaohong; Gu, Haitao; Huang, Wei; Peng, Jiangtong; Li, Yutian; Yang, Liwang; Qin, Dongze; Essandoh, Kobina; Wang, Yigang; Peng, Tianqing; Fan, Guo-Chang (2016. )Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice.Diabetes, ,65 (10 ),3111-28

Qin, Dongze; Wang, Xiaohong; Li, Yutian; Yang, Liwang; Wang, Ruitao; Peng, Jiangtong; Essandoh, Kobina; Mu, Xingjiang; Peng, Tianqing; Han, Qinghua; Yu, Kai-Jiang; Fan, Guo-Chang (2016. )MicroRNA-223-5p and -3p Cooperatively Suppress Necroptosis in Ischemic/Reperfused Hearts.The Journal of biological chemistry, ,291 (38 ),20247-59

Hu, Jing; Al-Waili, Daniah; Hassan, Aishlin; Fan, Guo-Chang; Xin, Mei; Hao, Jiukuan (2016. )Inhibition of cerebral vascular inflammation by brain endothelium-targeted oligodeoxynucleotide complex.Neuroscience, ,329 ,30-42

Liu, Zhi-Feng; Zheng, Dong; Fan, Guo-Chang; Peng, Tianqing; Su, Lei (2016. )Heat stress prevents lipopolysaccharide-induced apoptosis in pulmonary microvascular endothelial cells by blocking calpain/p38 MAPK signalling.Apoptosis : an international journal on programmed cell death, ,21 (8 ),896-904

Essandoh, Kobina; Li, Yutian; Huo, Jiuzhou; Fan, Guo-Chang (2016. )MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response.Shock (Augusta, Ga.), ,46 (2 ),122-31

Yang, Liwang; Li, Yutian; Wang, Xiaohong; Mu, Xingjiang; Qin, Dongze; Huang, Wei; Alshahrani, Saeed; Nieman, Michelle; Peng, Jiangtong; Essandoh, Kobina; Peng, Tianqing; Wang, Yigang; Lorenz, John; Soleimani, Manoocher; Zhao, Zhi-Qing; Fan, Guo-Chang (2016. )Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy.The Journal of biological chemistry, ,291 (30 ),15700-13

Zheng, Dong; Yu, Yong; Li, Minghui; Wang, Grace; Chen, Ruizhen; Fan, Guo-Chang; Martin, Claudio; Xiong, Sidong; Peng, Tianqing (2016. )Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis.The Journal of infectious diseases, ,213 (10 ),1661-70

Ni, Rui; Zheng, Dong; Xiong, Sidong; Hill, David J; Sun, Tao; Gardiner, Richard B; Fan, Guo-Chang; Lu, Yanrong; Abel, E Dale; Greer, Peter A; Peng, Tianqing (2016. )Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy.Diabetes, ,65 (1 ),255-68

Ni, Rui; Cao, Ting; Xiong, Sidong; Ma, Jian; Fan, Guo-Chang; Lacefield, James C; Lu, Yanrong; Le Tissier, Sydney; Peng, Tianqing (2016. )Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy.Free radical biology & medicine, ,90 ,12-23

Essandoh, Kobina; Yang, Liwang; Wang, Xiaohong; Huang, Wei; Qin, Dongze; Hao, Jiukuan; Wang, Yigang; Zingarelli, Basilia; Peng, Tianqing; Fan, Guo-Chang (2015. )Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction.Biochimica et biophysica acta, ,1852 (11 ),2362-71

Wang, Xiaohong; Gu, Haitao; Qin, Dongze; Yang, Liwang; Huang, Wei; Essandoh, Kobina; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Zingarelli, Basilia; Fan, Guo-Chang (2015. )Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis.Scientific reports, ,5 ,13721

Ni, Rui; Zheng, Dong; Wang, Qiang; Yu, Yong; Chen, Ruizhen; Sun, Tao; Wang, Wang; Fan, Guo-Chang; Greer, Peter A; Gardiner, Richard B; Peng, Tianqing (2015. )Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.Circulation. Heart failure, ,8 (5 ),988-96

Zheng, Dong; Ma, Jian; Yu, Yong; Li, Minghui; Ni, Rui; Wang, Grace; Chen, Ruizhen; Li, Jianmin; Fan, Guo-Chang; Lacefield, James C; Peng, Tianqing (2015. )Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice.Diabetologia, ,58 (8 ),1949-58

Cai, Wen-Feng; Liu, Guan-Sheng; Lam, Chi Keung; Florea, Stela; Qian, Jiang; Zhao, Wen; Pritchard, Tracy; Haghighi, Kobra; Lebeche, Djamel; Lu, Long Jason; Deng, Jingyuan; Fan, Guo-Chang; Hajjar, Roger J; Kranias, Evangelia G (2015. )Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility.European journal of heart failure, ,17 (8 ),782-93

Zheng, Dong; Wang, Grace; Li, Shuai; Fan, Guo-Chang; Peng, Tianqing (2015. )Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation.Biochimica et biophysica acta, ,1852 (5 ),882-92

Ailawadi, Shaina; Wang, Xiaohong; Gu, Haitao; Fan, Guo-Chang (2015. )Pathologic function and therapeutic potential of exosomes in cardiovascular disease.Biochimica et biophysica acta, ,1852 (1 ),1-11

Fan, Guo-Chang (2014. )Hypoxic exosomes promote angiogenesis.Blood, ,124 (25 ),3669-70

Li, Shang-Ze; Zhang, Hui-Hui; Liang, Jun-Bo; Song, Yang; Jin, Bing-Xue; Xing, Na-Na; Fan, Guo-Chang; Du, Run-Lei; Zhang, Xiao-Dong (2014. )Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKK?.Biochimica et biophysica acta, ,1843 (7 ),1365-72

Wang, Xiaohong; Huang, Wei; Liu, Guansheng; Cai, Wenfeng; Millard, Ronald W; Wang, Yigang; Chang, Jiang; Peng, Tianqing; Fan, Guo-Chang (2014. )Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells.Journal of molecular and cellular cardiology, ,

Essandoh, Kobina; Fan, Guo-Chang (2014. )Role of extracellular and intracellular microRNAs in sepsis.Biochimica et biophysica acta, ,1842 (11 ),2155-2162

Wen, Zhili; Huang, Wei; Feng, Yuliang; Cai, Wenfeng; Wang, Yuhua; Wang, Xiaohong; Liang, Jialiang; Wani, Mashhood; Chen, Jing; Zhu, Pin; Chen, Ji-Mei; Millard, Ronald W; Fan, Guo-Chang; Wang, Yigang (2014. )MicroRNA-377 Regulates Mesenchymal Stem Cell-Induced Angiogenesis in Ischemic Hearts by Targeting VEGF.PloS one, ,9 (9 ),e104666

Yue, X; Yang, X; Lin, X; Yang, T; Yi, X; Dai, Y; Guo, J; Li, T; Shi, J; Wei, L; Fan, G-C; Chen, C; Chang, J (2014. )Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure.Cell death & disease, ,5 ,e1284

Jiang, Ding-Sheng; Wei, Xiang; Zhang, Xiao-Fei; Liu, Yu; Zhang, Yan; Chen, Ke; Gao, Lu; Zhou, Heng; Zhu, Xue-Hai; Liu, Peter P; Bond Lau, Wayne; Ma, Xinliang; Zou, Yunzeng; Zhang, Xiao-Dong; Fan, Guo-Chang; Li, Hongliang (2014. )IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling.Nature communications, ,5 ,3303

Zhang, Yan; Liu, Yu; Zhu, Xue-Hai; Zhang, Xiao-Dong; Jiang, Ding-Sheng; Bian, Zhou-Yan; Zhang, Xiao-Fei; Chen, Ke; Wei, Xiang; Gao, Lu; Zhu, Li-Hua; Yang, Qinglin; Fan, Guo-Chang; Lau, Wayne B; Ma, Xinliang; Li, Hongliang (2014. )Dickkopf-3 attenuates pressure overload-induced cardiac remodelling.Cardiovascular research, ,

Zhang, Yan; Zhang, Xiao-Fei; Gao, Lu; Liu, Yu; Jiang, Ding-Sheng; Chen, Ke; Yang, Qinglin; Fan, Guo-Chang; Zhang, Xiao-Dong; Huang, Congxin (2014. )Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction.Biochimica et biophysica acta, ,1842 (2 ),232-44

Wang, Xiaohong; Huang, Wei; Yang, Yang; Wang, Yigang; Peng, Tianqing; Chang, Jiang; Caldwell, Charles C; Zingarelli, Basilia; Fan, Guo-Chang (2014. )Loss of duplexmiR-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis.Biochimica et biophysica acta, ,1842 (5 ),701-711

Jiang, Ding-Sheng; Liu, Yu; Zhou, Heng; Zhang, Yan; Zhang, Xiao-Dong; Zhang, Xiao-Fei; Chen, Ke; Gao, Lu; Peng, Juan; Gong, Hui; Chen, Yingjie; Yang, Qinglin; Liu, Peter P; Fan, Guo-Chang; Zou, Yunzeng; Li, Hongliang (2014. )Interferon Regulatory Factor 7 Functions as a Novel Negative Regulator of Pathological Cardiac Hypertrophy.Hypertension, ,

Liu, Yi; Jiang, Xiao-Li; Liu, Yu; Jiang, Ding-Sheng; Zhang, Yan; Zhang, Rui; Chen, Yingjie; Yang, Qinglin; Zhang, Xiao-Dong; Fan, Guo-Chang; Li, Hongliang (2014. )Toll-interacting protein (Tollip) negatively regulates pressure overload-induced ventricular hypertrophy in mice.Cardiovascular research, ,101 (1 ),87-96

Lu, Yan-Yun; Li, Zuo-Zhi; Jiang, Ding-Sheng; Wang, Lang; Zhang, Yan; Chen, Ke; Zhang, Xiao-Fei; Liu, Yi; Fan, Guo-Chang; Chen, Yingjie; Yang, Qinglin; Zhou, Yan; Zhang, Xiao-Dong; Liu, De-Pei; Li, Hongliang (2013. )TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death.Nature communications, ,4 ,2852

Jiang, Ding-Sheng; Luo, Yu-Xuan; Zhang, Ran; Zhang, Xiao-Dong; Chen, Hou-Zao; Zhang, Yan; Chen, Ke; Zhang, Shu-Min; Fan, Guo-Chang; Liu, Peter P; Liu, De-Pei; Li, Hongliang (2013. )Interferon Regulatory Factor 9 Protects Against Cardiac Hypertrophy by Targeting Myocardin.Hypertension, ,

Jiang, Ding-Sheng; Zhang, Xiao-Fei; Gao, Lu; Zong, Jing; Zhou, Heng; Liu, Yu; Zhang, Yan; Bian, Zhou-Yan; Zhu, Li-Hua; Fan, Guo-Chang; Zhang, Xiao-Dong; Li, Hongliang (2013. )Signal Regulatory Protein-? Protects Against Cardiac Hypertrophy Via the Disruption of Toll-Like Receptor 4 Signaling.Hypertension, ,

Li, Qi; Guo, Junli; Lin, Xi; Yang, Xiangsheng; Ma, Yanlin; Fan, Guo-Chang; Chang, Jiang (2013. )An Intragenic SRF-Dependent Regulatory Motif Directs Cardiac-Specific microRNA-1-1/133a-2 Expression.PloS one, ,8 (9 ),e75470

Jiang, Ding-Sheng; Bian, Zhou-Yan; Zhang, Yan; Zhang, Shu-Min; Liu, Yi; Zhang, Rui; Chen, Yingjie; Yang, Qinglin; Zhang, Xiao-Dong; Fan, Guo-Chang; Li, Hongliang (2013. )Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy.Hypertension, ,61 (6 ),1193-202

Zhu, Hongyan; Fan, Guo-Chang (2013. )Whether Circulating miRNAs or miRNA-Carriers Serve as Biomarkers for Acute Myocardial Infarction.Journal of biomarkers in drug development, ,1 (1 ),

Ribeiro, Mara Fernandes; Zhu, Hongyan; Millard, Ronald W; Fan, Guo-Chang (2013. )Exosomes Function in Pro- and Anti-Angiogenesis.Current angiogenesis, ,2 (1 ),54-59

Ma, Jian; Wei, Meng; Wang, Qiang; Li, Jianmin; Wang, Hao; Liu, Weihua; Lacefield, James C; Greer, Peter A; Karmazyn, Morris; Fan, Guo-Chang; Peng, Tianqing (2012. )Deficiency of Capn4 gene inhibits nuclear factor-?B (NF-?B) protein signaling/inflammation and reduces remodeling after myocardial infarction.The Journal of biological chemistry, ,287 (33 ),27480-9

Wang, Xiaohong; Zhu, Hongyan; Zhang, Xiaowei; Liu, Yong; Chen, Jing; Medvedovic, Mario; Li, Hongliang; Weiss, Mitchell J; Ren, Xiaoping; Fan, Guo-Chang (2012. )Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1.Cardiovascular research, ,94 (2 ),379-90

Zhu, Hongyan; Fan, Guo-Chang (2012. )Role of microRNAs in the reperfused myocardium towards post-infarct remodelling.Cardiovascular research, ,94 (2 ),284-92

Huang, Wei; Wang, Tao; Zhang, Dongsheng; Zhao, Tiemin; Dai, Bo; Ashraf, Atif; Wang, Xiaohong; Xu, Meifeng; Millard, Ronald W; Fan, Guo-Chang; Ashraf, Muhammad; Yu, Xi-Yong; Wang, Yigang (2012. )Mesenchymal stem cells overexpressing CXCR4 attenuate remodeling of postmyocardial infarction by releasing matrix metalloproteinase-9.Stem cells and development, ,21 (5 ),778-89

Haghighi, Kobra; Pritchard, Tracy; Bossuyt, Julie; Waggoner, Jason R; Yuan, Qunying; Fan, Guo-Chang; Osinska, Hanna; Anjak, Ahmad; Rubinstein, Jack; Robbins, Jeffrey; Bers, Donald M; Kranias, Evangelia G (2012. )The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase.Journal of molecular and cellular cardiology, ,52 (3 ),773-82

Zuo, Shi; Jones, W Keith; Li, Hongxia; He, Zhisong; Pasha, Zeeshan; Yang, Yueting; Wang, Yigang; Fan, Guo-Chang; Ashraf, Muhammad; Xu, Meifeng (2012. )Paracrine effect of Wnt11-overexpressing mesenchymal stem cells on ischemic injury.Stem cells and development, ,21 (4 ),598-608

Zhang, Xiaowei; Wang, Xiaohong; Zhu, Hongyan; Kranias, Evangelia G; Tang, Yaoliang; Peng, Tianqing; Chang, Jiang; Fan, Guo-Chang (2012. )Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2.PloS one, ,7 (3 ),e32765

Fan, Guo-Chang (2012. )Role of heat shock proteins in stem cell behavior.Progress in molecular biology and translational science, ,111 ,305-22

Ma, Yonggang; Zhang, Xiaowei; Bao, Huayan; Mi, Su; Cai, Wenfeng; Yan, Huimin; Wang, Qingqing; Wang, Ziyan; Yan, Jun; Fan, Guo-Chang; Fan, Guochang; Lindsey, Merry L; Hu, Zhuowei (2012. )Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice.PloS one, ,7 (7 ),e40763

Zhu, Hongyan; Fan, Guo-Chang (2011. )Extracellular/circulating microRNAs and their potential role in cardiovascular disease. American journal of cardiovascular disease, ,1 (2 ),138-149

Qian, Jiang; Vafiadaki, Elizabeth; Florea, Stela M; Singh, Vivek P; Song, Weizhong; Lam, Chi Kung; Wang, Yigang; Yuan, Qunying; Pritchard, Tracy J; Cai, Wenfeng; Haghighi, Kobra; Rodriguez, Patricia; Wang, Hong-Sheng; Sanoudou, Despina; Fan, Guo-Chang; Kranias, Evangelia G (2011. )Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling.Circulation research, ,108 (12 ),1429-38

Zhang, Xiaowei; Wang, Xiaohong; Zhu, Hongyan; Zhu, Cheng; Wang, Yigang; Pu, William T; Jegga, Anil G; Fan, Guo-Chang (2010. )Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death.Journal of molecular and cellular cardiology, ,49 (5 ),841-50

Fan, Guo-Chang; Kranias, Evangelia G (2010. )Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure.Journal of molecular and cellular cardiology, ,

Wang, Xiaohong; Zhang, Xiaowei; Ren, Xiao-Ping; Chen, Jing; Liu, Hongzhu; Yang, Junqi; Medvedovic, Mario; Hu, Zhuowei; Fan, Guo-Chang (2010. )MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury.Circulation, ,122 (13 ),1308-18

Chen, Guoli; Zhou, Xiaoyang; Florea, Stela; Qian, Jiang; Cai, Wenfeng; Zhang, Zhiguo; Fan, Guo-Chang; Lorenz, John; Hajjar, Roger J; Kranias, Evangelia G (2010. )Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis.Basic research in cardiology, ,105 (5 ),573-81

Huang, Wei; Zhang, Dongsheng; Millard, Ronald W; Wang, Tao; Zhao, Tiemin; Fan, Guo-Chang; Ashraf, Atif; Xu, Meifeng; Ashraf, Muhammad; Wang, Yigang (2010. )Gene manipulated peritoneal cell patch repairs infarcted myocardium.Journal of molecular and cellular cardiology, ,48 (4 ),702-12

Qian, Jiang; Ren, Xiaoping; Wang, Xiaohong; Zhang, Pengyuan; Jones, W Keith; Molkentin, Jeffery D; Fan, Guo-Chang; Kranias, Evangelia G (2009. )Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.Circulation research, ,105 (12 ),1223-31

Wang, Xiaohong; Zhao, Tiemin; Huang, Wei; Wang, Tao; Qian, Jiang; Xu, Meifeng; Kranias, Evangelia G; Wang, Yigang; Fan, Guo-Chang (2009. )Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors.Stem cells (Dayton, Ohio), ,27 (12 ),3021-31

Jones, W Keith; Fan, Guo-Chang; Liao, Siyun; Zhang, Jun-Ming; Wang, Yang; Weintraub, Neal L; Kranias, Evangelia G; Schultz, Jo El; Lorenz, John; Ren, Xiaoping (2009. )Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling.Circulation, ,120 (11 Suppl ),S1-9

Wang, Xiaohong; Zingarelli, Basilia; O'Connor, Michael; Zhang, Pengyuan; Adeyemo, Adeola; Kranias, Evangelia G; Wang, Yigang; Fan, Guo-Chang (2009. )Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation.Journal of molecular and cellular cardiology, ,47 (3 ),382-90

Zhao, Wen; Fan, Guo-Chang; Zhang, Zhi-Guo; Bandyopadhyay, Arun; Zhou, Xiaoyang; Kranias, Evangelia G (2009. )Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis.Basic research in cardiology, ,104 (4 ),377-89

Ren, Xiao-Ping; Wu, Jinghai; Wang, Xiaohong; Sartor, Maureen A; Qian, Jiang; Jones, Keith; Nicolaou, Persoulla; Pritchard, Tracy J; Fan, Guo-Chang (2009. )MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20.Circulation, ,119 (17 ),2357-66

Jones, W Keith; Fan, Guo-Chang; Liao, Siyun; Zhang, Jun-Ming; Wang, Yang; Weintraub, Neal L; Kranias, Evangelia G; Schultz, Jo El; Lorenz, John; Ren, Xiaoping (2009. )Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling.Circulation, ,120 (11 Suppl ),S1-9

Nicolaou, Persoulla; Knöll, Ralph; Haghighi, Kobra; Fan, Guo-Chang; Dorn, Gerald W; Hasenfub, Gerd; Kranias, Evangelia G (2008. )Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects.The Journal of biological chemistry, ,283 (48 ),33465-71

Fan, Guo-Chang; Zhou, Xiaoyang; Wang, Xiaohong; Song, Guojie; Qian, Jiang; Nicolaou, Persoulla; Chen, Guoli; Ren, Xiaoping; Kranias, Evangelia G (2008. )Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity.Circulation research, ,103 (11 ),1270-9

Chen, Guoli; Zhou, Xiaoyang; Nicolaou, Persoulla; Rodriguez, Patricia; Song, Guojie; Mitton, Bryan; Pathak, Anand; Zachariah, Amit; Fan, Guo-Chang; Dorn, Gerald W; Kranias, Evangelia G (2008. )A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation.The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ,22 (6 ),1790-6

Haghighi, Kobra; Chen, Guoli; Sato, Yoji; Fan, Guo-Chang; He, Suiwen; Kolokathis, Fotis; Pater, Luke; Paraskevaidis, Ioannis; Jones, W Keith; Dorn, Gerald W; Kremastinos, Dimitrios Th; Kranias, Evangelia G (2008. )A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids.Human mutation, ,29 (5 ),640-7

Zhang, Dongsheng; Fan, Guo-Chang; Zhou, Xiaoyang; Zhao, Tiemin; Pasha, Zeeshan; Xu, Meifeng; Zhu, Yi; Ashraf, Muhammad; Wang, Yigang (2008. )Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium.Journal of molecular and cellular cardiology, ,44 (2 ),281-92

Fan, Guo-Chang; Yuan, Qunying; Kranias, Evangelia G (2008. )Regulatory roles of junctin in sarcoplasmic reticulum calcium cycling and myocardial function.Trends in cardiovascular medicine, ,18 (1 ),1-5

Arvanitis, Demetrios A; Vafiadaki, Elizabeth; Fan, Guo-Chang; Mitton, Bryan A; Gregory, Kimberly N; Del Monte, Federica; Kontrogianni-Konstantopoulos, Aikaterini; Sanoudou, Despina; Kranias, Evangelia G (2007. )Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase.American journal of physiology. Heart and circulatory physiology, ,293 (3 ),H1581-9

Zhou, Xiaoyang; Fan, Guo-Chang; Ren, Xiaoping; Waggoner, Jason R; Gregory, Kimberly N; Chen, Guoli; Jones, W Keith; Kranias, Evangelia G (2007. )Overexpression of histidine-rich Ca-binding protein protects against ischemia/reperfusion-induced cardiac injury.Cardiovascular research, ,75 (3 ),487-97

Yuan, Qunying; Fan, Guo-Chang; Dong, Min; Altschafl, Beth; Diwan, Abhinav; Ren, Xiaoping; Hahn, Harvey H; Zhao, Wen; Waggoner, Jason R; Jones, Larry R; Jones, W Keith; Bers, Donald M; Dorn, Gerald W; Wang, Hong-Sheng; Valdivia, Héctor H; Chu, Guoxiang; Kranias, Evangelia G (2007. )Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity.Circulation, ,115 (3 ),300-9

Fan, Guo-Chang; Yuan, Qunying; Zhao, Wen; Chu, Guoxiang; Kranias, Evangelia G (2007. )Junctin is a prominent regulator of contractility in cardiomyocytes.Biochemical and biophysical research communications, ,352 (3 ),617-22

Fan, Guo-Chang; Yuan, Qunying; Song, Guojie; Wang, Yigang; Chen, Guoli; Qian, Jiang; Zhou, Xiaoyang; Lee, Yong J; Ashraf, Muhammad; Kranias, Evangelia G (2006. )Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1.Circulation research, ,99 (11 ),1233-42

Haghighi, Kobra; Kolokathis, Fotis; Gramolini, Anthony O; Waggoner, Jason R; Pater, Luke; Lynch, Roy A; Fan, Guo-Chang; Tsiapras, Dimitris; Parekh, Rohan R; Dorn, Gerald W; MacLennan, David H; Kremastinos, Dimitrios Th; Kranias, Evangelia G (2006. )A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.Proceedings of the National Academy of Sciences of the United States of America, ,103 (5 ),1388-93

Fan, Guo-Chang; Chu, Guoxiang; Kranias, Evangelia G (2005. )Hsp20 and its cardioprotection.Trends in cardiovascular medicine, ,15 (4 ),138-41

Fan, Guo-Chang; Ren, Xiaoping; Qian, Jiang; Yuan, Qunying; Nicolaou, Persoulla; Wang, Yang; Jones, W Keith; Chu, Guoxiang; Kranias, Evangelia G (2005. )Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury.Circulation, ,111 (14 ),1792-9

Fan, Guo-Chang; Gregory, Kimberly N; Zhao, Wen; Park, Woo Jin; Kranias, Evangelia G (2004. )Regulation of myocardial function by histidine-rich, calcium-binding protein.American journal of physiology. Heart and circulatory physiology, ,287 (4 ),H1705-11

Fan, Guo-Chang; Chu, Guoxiang; Mitton, Bryan; Song, Qiujing; Yuan, Qunying; Kranias, Evangelia G (2004. )Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis.Circulation research, ,94 (11 ),1474-82

Chu, Guoxiang; Egnaczyk, Gregory F; Zhao, Wen; Jo, Su-Hyun; Fan, Guo-Chang; Maggio, John E; Xiao, Rui-Ping; Kranias, Evangelia G (2004. )Phosphoproteome analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein p20.Circulation research, ,94 (2 ),184-93

Haghighi, Kobra; Kolokathis, Fotis; Pater, Luke; Lynch, Roy A; Asahi, Michio; Gramolini, Anthony O; Fan, Guo-Chang; Tsiapras, Dimitris; Hahn, Harvey S; Adamopoulos, Stamatis; Liggett, Stephen B; Dorn, Gerald W; MacLennan, David H; Kremastinos, Dimitrios T; Kranias, Evangelia G (2003. )Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.The Journal of clinical investigation, ,111 (6 ),869-76

Fan, Guo-Chang; Singh, Ram Raj (2002. )Vaccination with minigenes encoding V(H)-derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus. The Journal of experimental medicine, ,196 (6 ),731-41

Hong, Guangliang; Zheng, Dong; Zhang, Lulu; Ni, Rui; Wang, Grace; Fan, Guo-Chang; Lu, Zhongqiu; Peng, Tianqing (2018. )Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis.Free radical biology & medicine, ,123 ,125-137

Peng, Jiangtong; Li, Yutian; Wang, Xiaohong; Deng, Shan; Holland, Jenna; Yates, Emily; Chen, Jing; Gu, Haitao; Essandoh, Kobina; Mu, Xingjiang; Wang, Boyu; McNamara, Robert K; Peng, Tianqing; Jegga, Anil G; Liu, Tiemin; Nakamura, Takahisa; Huang, Kai; Perez-Tilve, Diego; Fan, Guo-Chang (2018. )An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR? Ubiquitination.Cell reports, ,23 (12 ),3607-3620

Chen, Yanfang; Tang, Yaoliang; Fan, Guo-Chang; Duan, Dayue Darrel (2018. )Extracellular vesicles as novel biomarkers and pharmaceutic targets of diseases.Acta pharmacologica Sinica, ,39 (4 ),499-500

Yu, You-Jiang; Wang, Xiao-Hong; Fan, Guo-Chang (2018. )Versatile effects of bacterium-released membrane vesicles on mammalian cells and infectious/inflammatory diseases.Acta pharmacologica Sinica, ,39 (4 ),514-533

Liu, Guan-Sheng; Zhu, Hongyan; Cai, Wen-Feng; Wang, Xiaohong; Jiang, Min; Essandoh, Kobina; Vafiadaki, Elizabeth; Haghighi, Kobra; Lam, Chi Keung; Gardner, George; Adly, George; Nicolaou, Persoulla; Sanoudou, Despina; Liang, Qiangrong; Rubinstein, Jack; Fan, Guo-Chang; Kranias, Evangelia G (2018. )Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6S10F mutant.Autophagy, ,14 (1 ),80-97

Salem, Esam S B; Fan, Guo-Chang (2017. )Pathological Effects of Exosomes in Mediating Diabetic Cardiomyopathy.Advances in experimental medicine and biology, ,998 ,113-138

Zheng, Dong; Cao, Ting; Zhang, Lu-Lu; Fan, Guo-Chang; Qiu, Jun; Peng, Tian-Qing (2020. )Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury.Acta pharmacologica Sinica, ,

Mu, Xingjiang; Wang, Peng; Wang, Xiaohong; Li, Yutian; Zhao, Hongyan; Li, Qianqian; Essandoh, Kobina; Deng, Shan; Peng, Tianqing; Fan, Guo-Chang (2020. )Identification of a Novel Antisepsis Pathway: Sectm1a Enhances Macrophage Phagocytosis of Bacteria through Activating GITR.Journal of immunology (Baltimore, Md. : 1950), ,205 (6 ),1633-1643

Essandoh, Kobina; Deng, Shan; Wang, Xiaohong; Li, Yutian; Li, Qianqian; Mu, Xingjiang; Peng, Tianqing; Fan, Guo-Chang (2020. )Tsg101 Is Involved in the Sorting and Re-Distribution of Glucose Transporter-4 to the Sarcolemma Membrane of Cardiac Myocytes.Cells, ,9 (9 ),

Li, Yutian; Li, Qianqian; Fan, Guo-Chang (2020. )Macrophage Efferocytosis in Cardiac Pathophysiology and Repair.Shock (Augusta, Ga.), ,

Mu, Xingjiang; Li, Yutian; Fan, Guo-Chang (2020. )Tissue-Resident Macrophages in the Control of Infection and Resolution of Inflammation.Shock (Augusta, Ga.), ,

Deng, Shan; Essandoh, Kobina; Wang, Xiaohong; Li, Yutian; Huang, Wei; Chen, Jing; Peng, Jiangtong; Jiang, Ding-Sheng; Mu, Xingjiang; Wang, Chenran; Peng, Tianqing; Guan, Jun-Lin; Wang, Yigang; Jegga, Anil; Huang, Kai; Fan, Guo-Chang (2020. )Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.Redox biology, ,32 ,101453

Li, Yutian; Deng, Shan; Wang, Xiaohong; Huang, Wei; Chen, Jing; Robbins, Nathan; Mu, Xingjiang; Essandoh, Kobina; Peng, Tianqing; Jegga, Anil G; Rubinstein, Jack; Adams, David E; Wang, Yigang; Peng, Jiangtong; Fan, Guo-Chang (2020. )Sectm1a Deficiency Aggravates Inflammation-Triggered Cardiac Dysfunction through Disruption of LXR? Signaling in Macrophages.Cardiovascular research, ,

Wang, Lu; Li, Yutian; Wang, Xiaohong; Wang, Peng; Essandoh, Kobina; Cui, Shunan; Huang, Wei; Mu, Xingjiang; Liu, Zhenling; Wang, Yigang; Peng, Tianqing; Fan, Guo-Chang (2020. )GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype.Cells, ,9 (1 ),

Essandoh, Kobina; Wang, Xiaohong; Huang, Wei; Deng, Shan; Gardner, George; Mu, Xingjiang; Li, Yutian; Kranias, Evangelia G; Wang, Yigang; Fan, Guo-Chang (2019. )Tumor susceptibility gene 101 ameliorates endotoxin-induced cardiac dysfunction by enhancing Parkin-mediated mitophagy.The Journal of biological chemistry, ,294 (48 ),18057-18068

Liang, Liwen; Yuan, Wenyi; Qu, Lina; Li, Huili; Zhang, Lulu; Fan, Guo-Chang; Peng, Tianqing (2019. )Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47phox phosphorylation, NADPH oxidase activation and MuRF1 expression.Journal of translational medicine, ,17 (1 ),279

Zheng, Dong; Zhang, Yi; Zheng, Ming; Cao, Ting; Wang, Grace; Zhang, Lulu; Ni, Rui; Brockman, Joseph; Zhong, Huiting; Fan, Guo-Chang; Peng, Tianqing (2019. )Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity.Clinical science (London, England : 1979), ,133 (13 ),1505-1521

Li, Yutian; Deng, Shan; Peng, Jiangtong; Wang, Xiaohong; Essandoh, Kobina; Mu, Xingjiang; Peng, Tianqing; Meng, Zhuo-Xian; Fan, Guo-Chang (2019. )MicroRNA-223 is essential for maintaining functional ?-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways.The Journal of biological chemistry, ,294 (27 ),10438-10448

Essandoh, Kobina; Deng, Shan; Wang, Xiaohong; Jiang, Min; Mu, Xingjiang; Peng, Jiangtong; Li, Yutian; Peng, Tianqing; Wagner, Kay-Uwe; Rubinstein, Jack; Fan, Guo-Chang (2019. )Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ,33 (6 ),7451-7466

Teng, Xiaomei; Ji, Chen; Zhong, Huiting; Zheng, Dong; Ni, Rui; Hill, David J; Xiong, Sidong; Fan, Guo-Chang; Greer, Peter A; Shen, Zhenya; Peng, Tianqing (2019. )Selective deletion of endothelial cell calpain in mice reduces diabetic cardiomyopathy by improving angiogenesis.Diabetologia, ,62 (5 ),860-872

Gardner, George T; Travers, Joshua G; Qian, Jiang; Liu, Guan-Sheng; Haghighi, Kobra; Robbins, Nathan; Jiang, Min; Li, Yutian; Fan, Guo-Chang; Rubinstein, Jack; Blaxall, Burns C; Kranias, Evangelia G (2019. )Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure.JACC. Basic to translational science, ,4 (2 ),188-199

Zheng, Dong; Su, Zhaoliang; Zhang, Yi; Ni, Rui; Fan, Guo-Chang; Robbins, Jeffrey; Song, Long-Sheng; Li, Jianmin; Peng, Tianqing (2019. )Calpain-2 promotes MKP-1 expression protecting cardiomyocytes in both in vitro and in vivo mouse models of doxorubicin-induced cardiotoxicity.Archives of toxicology, ,93 (4 ),1051-1065

Cao, Ting; Fan, Shuai; Zheng, Dong; Wang, Grace; Yu, Yong; Chen, Ruizhen; Song, Long-Sheng; Fan, Guo-Chang; Zhang, Zhuxu; Peng, Tianqing (2019. )Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion.Basic research in cardiology, ,114 (3 ),17

Ren, Xiaoping; Roessler, Anne E; Lynch, Thomas L; Haar, Lauren; Mallick, Faryal; Lui, Yong; Tranter, Michael; Ren, Michelle Huan; Xie, Wen Rui; Fan, Guo-Chang; Zhang, Jun-Ming; Kranias, Evangelia G; Anjak, Ahmad; Koch, Sheryl; Jiang, Min; Miao, Qing; Wang, Yang; Cohen, Albert; Rubinstein, Jack; Weintraub, Neal L; Jones, W Keith (2019. )Cardioprotection via the skin: nociceptor-induced conditioning against cardiac MI in the NIC of time.American journal of physiology. Heart and circulatory physiology, ,316 (3 ),H543-H553

Li, S; Zhang, L; Ni, R; Cao, T; Zheng, D; Xiong, S; Greer, P A; Fan, G C; Peng, T (2017. )Corrigendum to "Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress" [Biochim. Biophy.Acta 1862 (11): 2023-2033].Biochimica et biophysica acta. Molecular basis of disease, ,1863 (9 ),2409

Essandoh, Kobina; Fan, Guo-Chang (2014. )Role of extracellular and intracellular microRNAs in sepsis.Biochimica et biophysica acta, ,1842 (11 ),2155-2162

Wen, Zhili; Huang, Wei; Feng, Yuliang; Cai, Wenfeng; Wang, Yuhua; Wang, Xiaohong; Liang, Jialiang; Wani, Mashhood; Chen, Jing; Zhu, Pin; Chen, Ji-Mei; Millard, Ronald W; Fan, Guo-Chang; Wang, Yigang (2014. )MicroRNA-377 regulates mesenchymal stem cell-induced angiogenesis in ischemic hearts by targeting VEGF.PloS one, ,9 (9 ),e104666

Zhu, Hongyan; Fan, Guo-Chang (2013. )Whether Circulating miRNAs or miRNA-Carriers Serve as Biomarkers for Acute Myocardial Infarction.Journal of biomarkers in drug development, ,1 (1 ),

Other Publications

Fan GC and Wu CT (2000. )Transfer of p14ARF gene in drug-resistant human breast cancer MCF-7/Adr cells inhibits cell proliferation and reduces doxorubicin resistance .Cancer lett., 158 (2 ),203-210

Fan GC, Singh RR (2002. )Vaccination with minigenes encoding VH-derived MHC class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus .Exp. Med., 196 (6 ),731-741

22 Haghighi K, Kolokathis F, Pater L, Lynch RA, Asahi M, Gramolini AO, Fan GC, Tsiapras D, Hahn HS, Adamopoulos S, Liggett SB, Dorn GW 2nd, MacLennan DH, Kremastinos DT, Kranias EG (2003. )Human Phospholamban Null Results in Lethal Dilated Cardiomyopathy: Critical Difference Between Mouse and Man .J. Clin. Invest., 111 ,869-876

Fan GC, Gregory KN, Zhao W, Park WJ, Kranias EG (2004. )Regulation of Myocardial Function by Histidine-Rich Calcium Binding Protein .Am. J. Physiol., 287 (4 ),H1705-1711

Fan GC, Chu G, Mitton B, Song Q, Yuan Q, Kranias EG (2004. )Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis .Circ. Res., 94 (11 ),1474-1482

21 Chu G, Egnaczyk GF, Zhao W, Jo SH, Fan GC, Maggio JE, Xaio RP, and Kranias EG (2004. )Phosphoprotemoe analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein Hsp20 .Circ. Res., 94 (2 ),184-193

Fan GC, Chu G, Kranias EG (2005. )Hsp20 and its cardioprotection .Trends Cardiovasc. Med., 15 (4 ),138-141

Fan GC, Ren X, Qian J, Yuan Q, Nicolaou P, Wang Y, Jones WK, Chu G, Kranias EG (2005. )A novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury .Circulation, 111 (14 ),1792-1799

Fan GC, Yuan Q, Song G, Wang Y, Chen G, Qian J, Zhou X, Lee YJ, Ashraf M, Kranias EG (2006. )Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase .Circ Res., 99 (11 ),1233-1242

Haghighi K, Kolokathis F, Gramolini AO, Waggoner J, Pater L, Lynch RA., Fan GC, Tsiapras D, Parekh RR, Dorn GW, MacLennan DH, Kremastinos DK, Kranias EG (2006. )Human mutation in Phospholamban in the Human Phosphorylation gene, Deleting Arginine14, Results in Lethal Human Hereditary Cardiomyopathy .Proc. Natl. Acad. Sci., 103 (5 ),1388-1393

Arvanitis DA, Vafiadaki E, Fan GC, Mitton BA, Gregory KN, del Monte F, Kontrogianni-Konstantopoulos A, Sanoudou D, and Kranias EG (2007. )The Histidine-Rich Calcium Binding Protein Interacts with Sarcoplasmic Reticulum Ca-ATPase .Am J Physiol., 293 ,H1581-H1589

Zhou X, Fan GC, Ren X, Waggoner J, Gregory K, Chen G, Jones WK, Kranias EG (2007. )Overexpression of Histidine-Rich Ca-Binding Protein Protects Against Ischemia/Reperfusion-Induced Cardiac Injury .Cardiovascular Res., 75 (3 ),487-497

Yuan Q, Fan GC, Dong M, Altschafl M, Diwan A, Ren X, Zhao W, Waggoner JR, Jones LR, Jones WK, Bers DM, Dorn GW, Wang HS, Valdivia HH, Chu G, and Kranias EG (2007. )Sarcoplasmic Reticulum Calcium Overloading in Junctin Deficiency Enhances Cardiac Contractility, but Increases Ventricular Automaticity .Circulation, 115 (3 ),300-309

Fan GC, Yuan Q, Zhao W, Chu G, Kranias EG (2007. )Junctin Is a Prominent Regulator of Contractility in Cardiomyocytes .Biochem Biophys Res Commun., 352 (3 ),617-622

Wang X, Zingarelli B, Fan GC (2008. )Hsp20 prevents endotoxin-induced cardiac injury through downregulation of NF-kB activity.

Wang X, Zhang D, Zhao T, Wang Y, Ashraf M, Kranias EG and Fan GC (2008. )Bone-morrow stem cells modified with Hsp20 are resistant to oxidative stress and improve cardiac function via release of paracrine factors in the infarct heart .

Wu J, Ren X, Wang X, Sartor MA, Krainas EG, Jones WK, Fan GC (2008. )MiR-320 is an ischemia-related microRNA by targeting Hsp20 .Proc. Natl. Acad. Sci,

Fan GC, Liao S, Wang Y, Zhang J, Kranias EG, Schultz JE, Lorenz J, Jones WK, and Ren X (2008. )Neurogenic activation mediates remote non-ischemic cardioprotection via bradykinin receptor 2-dependent PKC signaling pathway .Circulation,

Zhao W, Fan GC, Bandyopadhyay A, Zhou X, Kranias EG (2008. )Peroxiredoxin II protects cardiomyocytes from oxidative stress-induced cell death and apoptosis .Cardiovascular Res.,

Fan GC*, Zhou X, Song G, Qian J, Kranias EG (2008. )Hsp20 Interacting With Phosphorylated Akt Reduces Doxorubicin-Triggered Oxidative Stress and Cardiotoxicity .Circ Res.,

Chen G, Zhou X, Rodriguez P, Song G, Mitton B, Pathak A, Fan GC, Dorn GW II, Kranias EG (2008. )A Human Polymorphism of Protein Phosphatase 1 Inhibitor 1 is Associated with Attenuated Cardiac Contractile Responses to Beta-adrenergic Stimulation .The FASEB Journal, 22 (6 ),1790-1796

Zhang D, Fan GC, Zhou X, Zhao T, Pasha Z, Xu M, Zhu Y, Ashraf M, Wang Y (2008. )Overexpression of CXCR4 in mesenchymal stem cells improves cardiac repair following infarction .J Mol Cell Cardiol., 44 (2 ),281-292

Fan GC, Yuan Q, Kranias EG (2008. )Regulatory Roles of Junctin in SR Ca Cycling and Myocardial Function .Trends Cardiovasc. Med., 18 (1 ),1-5

Haghighi K, Chen G, Sato Y, Fan GC, He S, Kolokathis F, Pater L, Paraskevaidis L, Jones KW, Kremastinos DT, and Kranias EG (2008. )A Human Phospholamban Promoter Mutation in Dilated Cardiomyopathy Alters Transcriptional Regulation by Glucocorticoids .Human Mutation, 29 (5 ),640-647

Book Chapter

Guo-Chang Fan, Evangelia G. Kranias (2010 )Small stress proteins in protecting the heart Small stress proteins and human diseases .(pp. 147-169).New York,Nova Science Publishers, Inc.(Author)

Hongyan Zhu, Guo-Chang Fan (04-09-2013 )Intracellular and Extracellular MicroRNAs in Myocardial Angiogenesis Cardiovascular Diseases Nutritional and Therapeutic Interventions .(pp. 163-186).New York,CRC Press(Author)

Electronic Journal

Hongyan Zhu, Guo-Chang Fan (08-02-2012. )Whether Circulating miRNAs or miRNA-Carriers Serve as Biomarkers for Acute Myocardial Infarction .Journal of Biomarkers in drug development, 1 (1 ),

Presentations

Invited Presentations

Guo-Chang Fan (05-12-2013. )Stress-Responsive Hsp20/miRs/Exosomes in Cardiovascular Disease .University of Mississippi Medical Center. Level:National

Guo-Chang Fan (07-15-2013. )Roles of microRNAs and Exosomes in Ischemic Heart Disease .Center for Cardiovascular Research, University of Illinois at Chicago . Level:National

Guo-Chang Fan (10-08-2013. )Hsp20 and Stem Cell-Derived Exosomes: Novel Regulators of Cardioprotection .Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine . Level:College

Guo-Chang Fan (03-04-2014. )Roles of microRNAs and Exosomes in Myocardial Angiogenesis .Cardiovascular Center of Excellence, University of Cincinnati . Level:College

Guo-Chang Fan (04-08-2014. )Exosomes in Cardiovascular Disease .Department of Molecular Genetics, Biochemistry & Microbiology University of Cincinnati . Level:College

Honors and Awards

2008 -2008 Outstanding Early-Career Investigator Award at the Basic Cardiovascular Sciences Conference 2008 Heart Failure: Molecular Mechanisms and Therapeutic Targets

2005 -2005 New Investigator Travel Award at the 2nd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences Targeting Heart Failure: New Science, New Tools, New Strategies

2003 -2003 Travel grant to the 7th Annual Scientific Meeting of the Heart Failure Society of America

1999 -1999 Distinguished Achievement Award, Beijing Institute of Radiation Medicine

1996 -1998 Graduate Scholarship for Ph.D., Zhejiang University, China

Student Advising

Kobina Essandoh (Master )Supervisor Status:Completed 2013

Lam Chi (Doctoral )Committee Member Status:Completed 2012

Tiffany Forde (Master )Committee Member Status:Completed 2010

Kristin Luther (Doctoral )Committee Member Status:In Progress

Guansheng Liu (Doctoral )Co-Chair Status:In Progress

Jiang Qian (Doctoral )Co-Chair Status:Completed 2009

Adeola Adeyemo (Doctoral )Lab Rotation Preceptor Status:Completed 2007

Allyson Hamlin (Doctoral )Lab Rotation Preceptor Status:Completed 2011

Yang Yang (Doctoral )Lab Rotation Preceptor Status:Completed 2012

Liwang Yang (Doctoral )Supervisor Status:In Progress

Dongze Qin (Doctoral )Supervisor Status:In Progress

Haitao Gu (Postdoctoral )Supervisor Status:In Progress

Xiaowei Zhang (Postdoctoral )Supervisor Status:Completed 2013

Pengyuan Zhang (Postdoctoral )Supervisor Status:Completed 2009

Hongyan Zhu (Postdoctoral )Supervisor Status:Completed 2011

Service

Department of Pharmacology and Cell Biophysics (Graduate Education Committee )Committee Member Type:Departmental Service Level:Department 2013

Department of Pharmacology and Cell Biophysics (Research Committee )Committee Member Type:Departmental Service Level:Department 2011

College of Medicine (Interviewed Flex PhD candidates )Member Type:University/College Service Level:College 02-18-2010

University of Cincinnati and CCHMC (Poster judge at the Capstone Poster Session for undergraduates working in labs )Member Type:University/College Service Level:University 08-05-2011

University of Cincinnati (CEG Pilot Project Review Committee )Committee Member Type:University/College Service Level:College 2011

University of Cincinnati (Poster judge at the 2012 UC Graduate Poster Forum )Member Type:University/College Service Level:University 03-02-2012

University of Cincinnati and CCHMC (judge for the Capstone Poster Session for undergraduates working in labs here at UC and CCHMC 2013 summer )Member Type:University/College Service Level:University 08-02-2013

University of Cincinnati (judge for the 2014 graduate Poster Forum )Member Type:University/College Service Level:University 02-28-2014

University of Cincinnati (judge for the Science Fair )Member Type:Service to Professional Associations Level:Local 03-15-2014

University of Cincinnati (CEG Pilot Project Review Committee )Member Type:University/College Service Level:University 05-20-2014

17th World Congress on Heart Disease, International Academy of Cardiology Annual Scientific Sessions 2012, Toronto, ON, Canada. (Scientific Advisory Board )Member Type:Service to Professional Associations Level:International 2012

18th World Congress on Heart Disease, International Academy of Cardiology Annual Scientific Sessions (Scientific Advisory Board )Member Type:Service to Professional Associations Level:International 2013

the American Heart Association’s annual Scientific Sessions conference (educational session )Member Type:Service to Professional Associations Level:National 11-20-2013

19th World Congress on Heart Disease, Bonston, July 25-28, 2014. (Scientific Advisory Board )Member Type:Service to Professional Associations Level:International 2014

Post Graduate Training and Education

07-01-1998-06-26-2000 Post-doc, Beijing Institute of Radiation Medicine, ,Beijing, China

10-01-2001-12-01-2005 Postdoctoral Research Associate, Dept. of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, , ,Cincinnati, OH

06-27-2000-10-01-2001 Postdoctoral Fellowship, Division of Immunology, University of Cincinnati College of Medicine, ,Cincinnati, OH

Contact Information

Academic - Cardiovascular Center Building
Room 5923
Cincinnati  Ohio, 45267-0575
Phone: 513-558-2340
guochang.fan@uc.edu