Yanbo Fan

Yanbo Fan

Assistant Professor

Vontz Center

COM Cancer Biology - 0521

Vontz Center
3125 Eden Avenue
Cincinnati, Ohio 45267

Professional Summary

The long-term goal of my research is to explore the molecular basis of vascular disease and the intersection of vascular disease and cancer. We aim to uncover novel therapeutic targets and approaches for prevention and treatment of cardiovascular disease and cancer. 

Recently, we demonstrated that transcription factor EB (TFEB), a master gene for autophagy and lysosome biogenesis, is critical to maitain vascular wall homeostasis. The main focuses of my laboratory are: 1) The roles of TFEB in angiogenesis, aortic aneurysm and tumor vascular biology. 2) Identification of novel molecular targets for the treatment of vascular diseases.

Education

Bachelor, Hebei Medical University 2000 (Clinical Medicine)

PhD, Peking University 2008 (Physiology)

Positions and Work Experience

07-2008 -06-2014 Research Fellow, University of Michigan, Ann Arbor,

07-2014 -08-2017 Research Investigator, University of Michigan, Ann Arbor,

09-2017 -10-2019 Research Assistant Professor, University of Michigan, Ann Arbor,

Research and Practice Interests

Research Support

Grant: #10POST3270008 Investigators:Yanbo Fan 07-01-2010 -06-30-2012 American Heart Association The protective role of KLF11 as a PPARgamma co-factor in vascular lesion formation. Role:PI Completed Type:Fellowship Level:National

Grant: #14SDG19880014 Investigators:Yanbo Fan 07-01-2014 -06-30-2018 American Heart Association Protective Role of KLF11 in Diabetic Vascular Lesion Formation Role:PI $70,000 annual Completed Type:Grant Level:National

Grant: #R01HL138094 Investigators:Yanbo Fan 09-01-2017 -05-31-2022 National Heart, Lung and Blood Institute Transcription Factor-EB and Postischemic Angiogenesis Role:PI $274,478 direct annual Active Type:Grant Level:National

Grant: #R01HL145176-01 Investigators:Yanbo Fan 06-03-2019 -05-31-2023 National Heart, Lung and Blood Institute The role of TFEB in aortic aneurysms Role:PI $353,336 direct annual Active Type:Grant Level:National

Grant: #R01HL068878-16 Investigators:Eugene Chen 01-01-2016 -11-30-2019 National Heart, Lung and Blood Institute PPAR-gamma and Vascular Disease Role:Co-investigator $250,000 direct annual Active Type:Grant

Grant: #R01HL138094 Investigators:Fan, Yanbo 06-01-2020 -05-31-2022 National Heart, Lung and Blood Institute Transcription Factor – EB and Postischemic Angiogenesis Role:PI $440,534.00 Awarded Level:Federal

Grant: #R01HL138094 Investigators:Fan, Yanbo 06-01-2020 -05-31-2022 National Heart, Lung and Blood Institute Transcription Factor – EB and Postischemic Angiogenesis Role:PI $440,534.00 Awarded Level:Federal

Grant: #R01HL145176 Investigators:Fan, Yanbo 06-01-2020 -05-31-2023 National Heart, Lung and Blood Institute The role of TFEB in aortic aneurysms Role:PI $549,023.86 Active Level:Federal

Publications

Peer Reviewed Publications

Lu, Haocheng; Sun, Jinjian; Liang, Wenying; Zhang, Jifeng; Rom, Oren; Garcia-Barrio, Minerva T; Li, Shengdi; Villacorta, Luis; Schopfer, Francisco J; Freeman, Bruce A; Chen, Y Eugene; Fan, Yanbo (2019. )Novel gene regulatory networks identified in response to nitro-conjugated linoleic acid in human endothelial cells.Physiological genomics, ,51 (6 ),224-233

Liang, Wenying*; Fan, Yanbo*,#; Lu, Haocheng; Chang, Ziyi; Hu, Wenting; Sun, Jinjian; Wang, Huilun; Zhu, Tianqing; Wang, Jintao; Adili, Reheman; Garcia-Barrio, Minerva T; Holinstat, Michael; Eitzman, Daniel; Zhang, Jifeng; Chen, Y Eugene (2019. )KLF11 (Krüppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall.Arteriosclerosis, thrombosis, and vascular biology, ,39 (3 ),402-412

Rom, Oren; Xu, Guan; Guo, Yanhong; Zhu, Yunhao; Wang, Huilun; Zhang, Jifeng; Fan, Yanbo; Liang, Wenying; Lu, Haocheng; Liu, Yuhao; Aviram, Michael; Liu, Zhipeng; Kim, Seongho; Liu, Wanqing; Wang, Xueding; Chen, Y Eugene; Villacorta, Luis (2019. )Nitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice.EBioMedicine, ,41 ,62-72

Hu, Wenting; Lu, Haocheng; Zhang, Jifeng; Fan, Yanbo; Chang, Ziyi; Liang, Wenying; Wang, Huilun; Zhu, Tianqing; Garcia-Barrio, Minerva T; Peng, Daoquan; Chen, Y Eugene; Guo, Yanhong (2018. )Krüppel-like factor 14, a coronary artery disease associated transcription factor, inhibits endothelial inflammation via NF-?B signaling pathway.Atherosclerosis, ,278 ,39-48

Xiong, Wenhao; Zhao, Xiangjie; Villacorta, Luis; Rom, Oren; Garcia-Barrio, Minerva T; Guo, Yanhong; Fan, Yanbo; Zhu, Tianqing; Zhang, Jifeng; Zeng, Rong; Chen, Y Eugene; Jiang, Zhisheng; Chang, Lin (2018. )Brown Adipocyte-Specific PPAR? (Peroxisome Proliferator-Activated Receptor ?) Deletion Impairs Perivascular Adipose Tissue Development and Enhances Atherosclerosis in Mice.Arteriosclerosis, thrombosis, and vascular biology, ,38 (8 ),1738-1747

Chang, Lin; Xiong, Wenhao; Zhao, Xiangjie; Fan, Yanbo; Guo, Yanhong; Garcia-Barrio, Minerva; Zhang, Jifeng; Jiang, Zhisheng; Lin, Jiandie D; Chen, Y Eugene (2018. )Bmal1 in Perivascular Adipose Tissue Regulates Resting-Phase Blood Pressure Through Transcriptional Regulation of Angiotensinogen.Circulation, ,138 (1 ),67-79

Fan, Yanbo#; Lu, Haocheng; Liang, Wenying; Garcia-Barrio, Minerva T; Guo, Yanhong; Zhang, Ji; Zhu, Tianqing; Hao, Yibai; Zhang, Jifeng; Chen, Y Eugene (2018. )Endothelial TFEB (Transcription Factor EB) Positively Regulates Postischemic Angiogenesis.Circulation research, ,122 (7 ),945-957

Qiao, Congzhen; Li, Shengdi; Lu, Haocheng; Meng, Fan; Fan, Yanbo; Guo, Yanhong; Chen, Y Eugene; Zhang, Jifeng (2018. )Laminar Flow Attenuates Macrophage Migration Inhibitory Factor Expression in Endothelial Cells.Scientific reports, ,8 (1 ),2360

Fan, Yanbo#; Lu, Haocheng; Liang, Wenying; Hu, Wenting; Zhang, Jifeng; Chen, Y Eugene (2017. )Krüppel-like factors and vascular wall homeostasis.Journal of molecular cell biology, ,9 (5 ),352-363

Zhang, Jifeng; Niimi, Manabu; Yang, Dongshan; Liang, Jingyan; Xu, Jie; Kimura, Tokuhide; Mathew, Anna V; Guo, Yanhong; Fan, Yanbo; Zhu, Tianqing; Song, Jun; Ackermann, Rose; Koike, Yui; Schwendeman, Anna; Lai, Liangxue; Pennathur, Subramaniam; Garcia-Barrio, Minerva; Fan, Jianglin; Chen, Y Eugene (2017. )Deficiency of Cholesteryl Ester Transfer Protein Protects Against Atherosclerosis in Rabbits.Arteriosclerosis, thrombosis, and vascular biology, ,37 (6 ),1068-1075

Lu, Haocheng*; Fan, Yanbo*,#; Qiao, Congzhen; Liang, Wenying; Hu, Wenting; Zhu, Tianqing; Zhang, Jifeng; Chen, Y Eugene (2017. )TFEB inhibits endothelial cell inflammation and reduces atherosclerosis.Science signaling, ,10 (464 ),

Zhang, Ji; Qiao, Congzhen; Chang, Lin; Guo, Yanhong; Fan, Yanbo; Villacorta, Luis; Chen, Y Eugene; Zhang, Jifeng (2016. )Cardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy.PloS one, ,11 (6 ),e0157372

Fan, Yanbo; Lu, Haocheng; Guo, Yanhong; Zhu, Tianqing; Garcia-Barrio, Minerva T; Jiang, Zhisheng; Willer, Cristen J; Zhang, Jifeng; Chen, Y Eugene (2016. )Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice.Gastroenterology, ,150 (5 ),1208-1218

Guo, Yanhong; Fan, Yanbo; Zhang, Jifeng; Lomberk, Gwen A; Zhou, Zhou; Sun, Lijie; Mathison, Angela J; Garcia-Barrio, Minerva T; Zhang, Ji; Zeng, Lixia; Li, Lei; Pennathur, Subramaniam; Willer, Cristen J; Rader, Daniel J; Urrutia, Raul; Chen, Y Eugene (2015. )Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.The Journal of clinical investigation, ,125 (10 ),3819-30

Yin, Ke-Jie; Hamblin, Milton; Fan, Yanbo; Zhang, Jifeng; Chen, Y Eugene (2015. )Krüpple-like factors in the central nervous system: novel mediators in stroke.Metabolic brain disease, ,30 (2 ),401-10

Holmen, Oddgeir L*; Zhang, He*; Fan, Yanbo*; Hovelson, Daniel H; Schmidt, Ellen M; Zhou, Wei; Guo, Yanhong; Zhang, Ji; Langhammer, Arnulf; Løchen, Maja-Lisa; Ganesh, Santhi K; Vatten, Lars; Skorpen, Frank; Dalen, Håvard; Zhang, Jifeng; Pennathur, Subramaniam; Chen, Jin; Platou, Carl; Mathiesen, Ellisiv B; Wilsgaard, Tom; Njølstad, Inger; Boehnke, Michael; Chen, Y Eugene; Abecasis, Gonçalo R; Hveem, Kristian; Willer, Cristen J (2014. )Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk.Nature genetics, ,46 (4 ),345-51

Yang, Dongshan; Zhang, Jifeng; Xu, Jie; Zhu, Tianqing; Fan, Yanbo; Fan, Jianglin; Chen, Y Eugene (2013. )Production of apolipoprotein C-III knockout rabbits using zinc finger nucleases.Journal of visualized experiments : JoVE, ,(81 ),e50957

Liu, Ling; Zhou, Zhou; Huang, Shengping; Guo, Yanhong; Fan, Yanbo; Zhang, Ji; Zhang, Jifeng; Fu, Mingui; Chen, Y Eugene (2013. )Zc3h12c inhibits vascular inflammation by repressing NF-?B activation and pro-inflammatory gene expression in endothelial cells.The Biochemical journal, ,451 (1 ),55-60

Yin, Ke-Jie*; Fan, Yanbo*; Hamblin, Milton; Zhang, Jifeng; Zhu, Tainqing; Li, Siming; Hawse, John R; Subramaniam, Malayannan; Song, Chao-Zhong; Urrutia, Raul; Lin, Jiandie D; Chen, Y Eugene (2013. )KLF11 mediates PPAR? cerebrovascular protection in ischaemic stroke.Brain : a journal of neurology, ,136 (Pt 4 ),1274-87

Guo, Yanhong; Fan, Yanbo; Zhang, Jifeng; Chang, Lin; Lin, Jiandie D; Chen, Y Eugene (2013. )Peroxisome proliferator-activated receptor ? coactivator 1? (PGC-1?) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells.The Journal of biological chemistry, ,288 (7 ),4625-36

Fan, Yanbo; Guo, Yanhong; Zhang, Jifeng; Subramaniam, Malayannan; Song, Chao-Zhong; Urrutia, Raul; Chen, Y Eugene (2012. )Krüppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-?B signaling pathway.Arteriosclerosis, thrombosis, and vascular biology, ,32 (12 ),2981-8

Fan, Yanbo; Guo, Yanhong; Hamblin, Milton; Chang, Lin; Zhang, Jifeng; Chen, Y Eugene (2011. )Inhibition of gluconeogenic genes by calcium-regulated heat-stable protein 1 via repression of peroxisome proliferator-activated receptor ?.The Journal of biological chemistry, ,286 (47 ),40584-94

Fan, Yanbo; Chen, Y Eugene (2011. )Combined therapeutic strategy to improve vascular endothelial function after implantation of sirolimus-eluting stents.Circulation journal : official journal of the Japanese Circulation Society, ,75 (5 ),1051-2

Hamblin, Milton; Chang, Lin; Fan, Yanbo; Zhang, Jifeng; Chen, Y Eugene (2009. )PPARs and the cardiovascular system.Antioxidants & redox signaling, ,11 (6 ),1415-52

Zhang, Peng; Wang, Ying; Fan, Yanbo; Tang, Zhihui; Wang, Nanping (2009. )Overexpression of adiponectin receptors potentiates the antiinflammatory action of subeffective dose of globular adiponectin in vascular endothelial cells.Arteriosclerosis, thrombosis, and vascular biology, ,29 (1 ),67-74

Zhou, Yunfeng; Zhang, Xiaoyan; Chen, Lihong; Wu, Jing; Dang, Huaixin; Wei, Mingfen; Fan, Yanbo; Zhang, Yahua; Zhu, Yi; Wang, Nanping; Breyer, Matthew D; Guan, Youfei (2008. )Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats.American journal of physiology. Renal physiology, ,295 (3 ),F662-71

Zhang, Hong; Li, Yuanyuan; Fan, Yanbo; Wu, Jing; Zhao, Beilei; Guan, Youfei; Chien, Shu; Wang, Nanping (2008. )Klotho is a target gene of PPAR-gamma.Kidney international, ,74 (6 ),732-9

Tang, Zhihui; Wang, Ying; Fan, Yanbo; Zhu, Yi; Chien, Shu; Wang, Nanping (2008. )Suppression of c-Cbl tyrosine phosphorylation inhibits neointimal formation in balloon-injured rat arteries.Circulation, ,118 (7 ),764-72

Qin, Xiaomei; Xie, Xuefen; Fan, Yanbo; Tian, Jianwei; Guan, Youfei; Wang, Xian; Zhu, Yi; Wang, Nanping (2008. )Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice.Hepatology (Baltimore, Md.), ,48 (2 ),432-41

Fan, Yanbo; Wang, Ying; Tang, Zhihui; Zhang, Hong; Qin, Xiaomei; Zhu, Yi; Guan, Youfei; Wang, Xian; Staels, Bart; Chien, Shu; Wang, Nanping (2008. )Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells.Arteriosclerosis, thrombosis, and vascular biology, ,28 (2 ),315-21

Qin, Xiaomei; Tian, Jianwei; Zhang, Peng; Fan, Yanbo; Chen, Li; Guan, Youfei; Fu, Yi; Zhu, Yi; Chien, Shu; Wang, Nanping (2007. )Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells.Cardiovascular research, ,74 (3 ),506-14

Lu, Haocheng; Sun, Jinjian; Liang, Wenying; Chang, Ziyi; Rom, Oren; Zhao, Yang; Zhao, Guizhen; Xiong, Wenhao; Wang, Huilun; Zhu, Tianqing; Guo, Yanhong; Chang, Lin; Garcia-Barrio, Minerva T; Zhang, Jifeng; Chen, Y Eugene; Fan, Yanbo (2020. )Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell TFEB.Circulation, ,

Zhao, Yang; Chang, Ziyi; Zhao, Guizhen; Lu, Haocheng; Xiong, Wenhao; Liang, Wenying; Wang, Huilun; Villacorta, Luis; Garcia-Barrio, Minerva T; Zhu, Tianqing; Guo, Yanhong; Fan, Yanbo; Chang, Lin; Schopfer, Francisco J; Freeman, Bruce A; Zhang, Jifeng; Chen, Y Eugene (2020. )Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy.Cardiovascular drugs and therapy, ,

Sun, Yifang; Venugopal, Jessica; Guo, Chiao; Fan, Yanbo; Li, Jianping; Gong, Yanjun; Chen, Y Eugene; Zhang, Haoming; Eitzman, Daniel T (2020. )Clopidogrel Resistance in a Murine Model of Diet-Induced Obesity Is Mediated by the Interleukin-1 Receptor and Overcome With DT-678.Arteriosclerosis, thrombosis, and vascular biology, ,ATVBAHA120314146

Zhang, Xuejing; Tang, Xuelian; Ma, Feifei; Fan, Yanbo; Sun, Ping; Zhu, Tianqing; Zhang, Jifeng; Hamblin, Milton H; Chen, Y Eugene; Yin, Ke-Jie (2020. )Endothelium-targeted overexpression of Krüppel-like factor 11 protects the blood-brain barrier function after ischemic brain injury.Brain pathology (Zurich, Switzerland), ,

Honors and Awards

2010 -2012 AHA Postdoc Fellowship Status:Recipient Level:National Type:Fellowship

2007 -2007 Guanghua Prize for Excellence in Graduate Study Status:Recipient Level:University

2014 -2018 Scientist Development Award, American Heart Association Status:Recipient Level:National Type:Grant

2017 -2018 McKay Award, Frankel Cardiovascular Center, University of Michigan Level:Department Type:Grant

Post Graduate Training and Education

07-2008-06-2014 Research Fellow, Postdoc training, University of Michigan, ,Ann Arbor, MI

Keywords

cardiovascular disease angiogenesis aortic aneurysm atherosclerosis inflammation tumor vascular biology

Contact Information

Research - Vontz Center
3125 Eden Avenue
Cincinnati  Ohio, 45267
Phone: 558-5343
fanyb@uc.du