David E. Fleck , PhD

DR. DAVID FLECK is a Research Associate Professor with the Center for Imaging Research in the Department of Psychiatry and Behavioral Neuroscience. He completed his Bachelors and Masters degrees at Cleveland State University and received his Ph.D. in Neuropsychology in 1997 from the University of Cincinnati. Dr. Fleck also completed a Postdoctoral Fellowship at the University of Cincinnati Department of Psychiatry in 2003. His primary research interests include the neuropsychology of attention and memory; cognitive and physiological consequences of psychopathology and neuropathology; and cultural differences in the course and treatment of bipolar disorder. He has received support for his research efforts from the National Institute of Mental Health (NIMH), National Alliance for Research on Schizophrenia and Depression (NARSAD), AstraZeneca Pharmaceuticals, and the University of Cincinnati Research Council.

Bachelor's Degree: Cleveland State University

Master's Degree: Cleveland State University

Doctoral Degree: University of Cincinnati 1997 (Neuropsychology)

Post-Doctoral Fellowship: University of Cincinnati 2003 (Psychiatry)

Dr. Fleck's primary research interests include the neuropsychology of attention and memory; cognitive and physiological consequences of psychopathology and neuropathology; and cultural differences in the course and treatment of bipolar disorder.

He has received support for his research efforts from the National Institute of Mental Health (NIMH), National Alliance for Research on Schizophrenia and Depression (NARSAD), AstraZeneca Pharmaceuticals and the University of Cincinnati Research Council.

Grant: #K23-MH-070849 Investigators:Fleck, David 08-01-2004 -07-31-2009 National Institute of Mental Health Manic Distractibility and Frontosubcortical Processing Role:PI $663,992.00 Closed Level:Federal

Grant: #5-F32-MH-12883-03-A0-S0-E0 Investigators:Fleck, David 09-01-2000 -08-31-2003 National Institute of Mental Health Directed Forgetting in Bipolar Disorder Role:PI $139,564.00 Closed Level:Federal

Grant: #NARSAD FY04-01-A0-S0-E0 Investigators:Fleck, David 07-01-2002 -06-30-2004 National Alliance for Research on Schizophrenia and Depression Noncompliance with Maintenance Pharmacotherapy Treatment in African-American & Caucasian Patients with Bipolar Disorder Role:PI $39,075.00 Closed Level:Private Non-Profit

Grant: #R01 AG034617- Investigators:Fleck, David; Krikorian, Robert; McNamara, Robert; Nasrallah, Henry; Welge, Jeffrey 09-30-2009 -08-31-2014 National Institute on Aging Omega-3 and Blueberry Supplementation in Age-Related Cognitive Decline Role:Collaborator $1,331,722.00 Active Level:Federal

Grant: #K23 MH092735 Investigators:Espay, Alberto; Fleck, David; Szaflarski, Jerzy 07-15-2011 -04-30-2016 National Institute of Mental Health Psychogenic Tremor: Functional Magnetic Resonance Study on Emotional Processing Role:Collaborator $531,312.00 Active Level:Federal

Grant: #VA IPA - David Fleck Investigators:Fleck, David 01-03-2017 -01-02-2018 Department of Veterans Affairs Office of Research & Developm IPA for David Fleck Role:PI $29,271.00 Active Level:Federal

Grant: #R01MH125867 Investigators:Adler, Caleb; Cohen, Kelly; Delbello, Melissa; Fleck, David; Welge, Jeffrey 08-01-2021 -07-31-2026 National Institute of Mental Health 2/2-Neurodevelopmental and Clinical Trajectories of Youth at Risk for Bipolar I Disorder (Original Proposal is #14381) Role:Collaborator 630956.00 Hold Level:Federal

Grant: #VA IPA David Fleck Investigators:Fleck, David 01-03-2022 -01-02-2023 Department of Veterans Affairs Office of Research & Developm VA IPA for David Fleck Role:PI 33231.84 Hold Level:Federal

Investigators:Fleck, David 08-30-2023 -08-30-2026 Click Therapeutics A Study to Evaluate the Efficacy and Safety of a Digital Therapeutic (CT-155) as anAdjunct to Standard-of-Care Antipsychotic Therapy Role:PI 140564.26 Hold Level:Industry

Published Abstracts

Fleck, D.E., Shear, P.K., Kowatch, R.A., & Strakowski, S.M. (2005. ) Cognitive performance in bipolar disorder: A processing efficiency account .[Abstract]Neuropsychopharamacology, 30 (Suppl. 1 ) ,S111

Fleck, D.E., Shear, P.K., Kowatch, R.A., & Strakowski, S.M. (2006. ) Cognitive performance in bipolar disorder: A processing efficiency account .[Abstract]Journal of the International Neuropsychological Society, 12 ,

Fleck, D.E., Eliassen, J.C., Durling, M., Adams, J., Lamy, M., Williams, K., & Strakowski, S.M. (2007. ) Manic distractibility and frontosubcortical processing .[Abstract]Journal of Investigative Medicine, 55 ,S354

Burciaga, J., Madore, M.R., Hall, J., Fleck, D.E., Shear, P.K., & Strakowski, S.M. (02-2008. ) Psychomotor deficits in patients with bipolar disorder .[Abstract]Journal of the International Neuropsychological Society,

Fleck, D.E., Eliassen, J.C., Adler, C.M., DelBello, M.P., Shear, P.K., Durling, M., Cerullo, M.A., Lamy, M., & Strakowski, S.M. (2008. ) The neurophysiological correlates of sustained attention in bipolar mania .[Abstract]Journal of Investigative Medicine, 56 ,628

Cerullo, M.A., Eliassen, J.C., Fleck, D.E., Adler, C.M., DelBello, M.P., & Strakowski, S.M. (2009. ) The utility of using subjects with unipolar depression as comparison subjects in fMRI studies of bipolar disorder .[Abstract]Journal of Investigative Medicine, 57 ,535

Fleck, D.E., Kotwal, R., Eliassen, J.C., Lamy, M., Delbello, M.P., Adler, C.M., Durling, M., Cerullo, M.A., & Strakowski, S.M. (2009. ) Functional magnetic resonance imaging of motor impulsivity in bipolar depression .[Abstract]Journal of Investigative Medicine, 57 ,538

Peer Reviewed Publications

Gara, Michael A; Vega, William A; Lesser, Ira; Escamilla, Michael; Lawson, William B; Wilson, Daniel R; Fleck, David E; Strakowski, Stephen M (2010. ) The role of complex emotions in inconsistent diagnoses of schizophrenia.The Journal of nervous and mental disease, , 198 (9 ) ,609-13 More Information

Strakowski, Stephen M; Fleck, David E; DelBello, Melissa P; Adler, Caleb M; Shear, Paula K; Kotwal, Renu; Arndt, Stephan (2010. ) Impulsivity across the course of bipolar disorder.Bipolar disorders, , 12 (3 ) ,285-97 More Information

Strawn, Jeffrey R; Adler, Caleb M; Fleck, David E; Hanseman, Dennis; Maue, Danielle K; Bitter, Samantha; Kraft, Elizabeth M; Geracioti, Thomas D; Strakowski, Stephen M; DelBello, Melissa P (2010. ) Post-traumatic stress symptoms and trauma exposure in youth with first episode bipolar disorder.Early intervention in psychiatry, , 4 (2 ) ,169-73 More Information

Strakowski, Stephen M; Fleck, David E; DelBello, Melissa P; Adler, Caleb M; Shear, Paula K; McElroy, Susan L; Keck, Paul E; Moss, Quinton; Cerullo, Michael A; Kotwal, Renu; Arndt, Stephan (2009. ) Characterizing impulsivity in mania.Bipolar disorders, , 11 (1 ) ,41-51 More Information

Singh, Manpreet K; DelBello, Melissa P; Fleck, David E; Shear, Paula K; Strakowski, Stephen M (2009. ) Inhibition and attention in adolescents with nonmanic mood disorders and a high risk for developing mania.Journal of clinical and experimental neuropsychology, , 31 (1 ) ,1-7 More Information

Heffner, Jaimee L; DelBello, Melissa P; Fleck, David E; Anthenelli, Robert M; Strakowski, Stephen M (2008. ) Cigarette smoking in the early course of bipolar disorder: association with ages-at-onset of alcohol and marijuana use.Bipolar disorders, , 10 (7 ) ,838-45 More Information

Strakowski, Stephen M; Adler, Caleb M; Cerullo, Michael A; Eliassen, James C; Lamy, Martine; Fleck, David E; Lee, Jing-Huei; Delbello, Melissa P (2008. ) MRI brain activation in first-episode bipolar mania during a response inhibition task.Early intervention in psychiatry, , 2 (4 ) ,225-233 More Information

Fleck, David E; Shear, Paula K; Madore, Michelle; Strakowski, Stephen M (2008. ) Wisconsin Card Sorting Test performance in bipolar disorder: effects of mood state and early course.Bipolar disorders, , 10 (4 ) ,539-45 More Information

Fleck, David E; Nandagopal, Jayasree; Cerullo, Michael A; Eliassen, James C; DelBello, Melissa P; Adler, Caleb M; Strakowski, Stephen M (2008. ) Morphometric magnetic resonance imaging in psychiatry.Topics in magnetic resonance imaging : TMRI, , 19 (2 ) ,131-42 More Information

Strakowski, Stephen M; Tsai, Shang-Ying; Delbello, Melissa P; Chen, Chiao-Chicy; Fleck, David E; Adler, Caleb M; Arndt, Stephan; Amicone, Jennifer (2007. ) Outcome following a first manic episode: cross-national US and Taiwan comparison.Bipolar disorders, , 9 (8 ) ,820-7 More Information

Barzman, Drew H; DelBello, Melissa P; Fleck, David E; Lehmkuhl, Heather; Strakowski, Stephen M (2007. ) Rates, types, and psychosocial correlates of legal charges in adolescents with newly diagnosed bipolar disorder.Bipolar disorders, , 9 (4 ) ,339-44 More Information

DelBello, Melissa P; Hanseman, Dennis; Adler, Caleb M; Fleck, David E; Strakowski, Stephen M (2007. ) Twelve-month outcome of adolescents with bipolar disorder following first hospitalization for a manic or mixed episode.The American journal of psychiatry, , 164 (4 ) ,582-90 More Information

Strakowski, Stephen M; DelBello, Melissa P; Fleck, David E; Adler, Caleb M; Anthenelli, Robert M; Keck, Paul E; Arnold, Lesley M; Amicone, Jennifer (2007. ) Effects of co-occurring cannabis use disorders on the course of bipolar disorder after a first hospitalization for mania.Archives of general psychiatry, , 64 (1 ) ,57-64 More Information

Adler, Caleb M; Fleck, David E; Brecher, Martin; Strakowski, Stephen M (2007. ) Safety and tolerability of quetiapine in the treatment of acute mania in bipolar disorder.Journal of affective disorders, , 100 Suppl 1 ,S15-22 More Information

Fleck, David E; Arndt, Stephan; DelBello, Melissa P; Strakowski, Stephen M (2006. ) Concurrent tracking of alcohol use and bipolar disorder symptoms.Bipolar disorders, , 8 (4 ) ,338-44 More Information

Moss, Q; Fleck, D E; Strakowski, S M (2006. ) The influence of religious affiliation on time to first treatment and hospitalization.Schizophrenia research, , 84 (2-3 ) ,421-6 More Information

Fleck, David E; Shear, Paula K; Strakowski, Stephen M (2005. ) Processing efficiency and directed forgetting in bipolar disorder. Journal of the International Neuropsychological Society : JINS, , 11 (7 ) ,871-80

Strakowski, Stephen M; DelBello, Melissa P; Fleck, David E; Adler, Caleb M; Anthenelli, Robert M; Keck, Paul E; Arnold, Lesley M; Amicone, Jennifer (2005. ) Effects of co-occurring alcohol abuse on the course of bipolar disorder following a first hospitalization for mania.Archives of general psychiatry, , 62 (8 ) ,851-8 More Information

Fleck, David E; Keck, Paul E; Corey, Kimberly B; Strakowski, Stephen M (2005. ) Factors associated with medication adherence in African American and white patients with bipolar disorder. The Journal of clinical psychiatry, , 66 (5 ) ,646-52

Fleck, David E; Shear, Paula K; Strakowski, Stephen M (2005. ) Processing efficiency and sustained attention in bipolar disorder.Journal of the International Neuropsychological Society : JINS, , 11 (1 ) ,49-57 More Information

Fleck, David E; DelBello, Melissa P; Zimmerman, Molly E; Getz, Glen E; Shear, Paula K; Strakowski, Stephen M (2004. ) Selective attention in schizoaffective disorder: pilot data.Schizophrenia research, , 68 (1 ) ,109-10 More Information

Krikorian, Robert; Zimmerman, Molly E; Fleck, David E (2004. ) Inhibitory control in Obsessive-Compulsive Disorder.Brain and cognition, , 54 (3 ) ,257-9 More Information

Arnold, Lesley M; Keck, Paul E; Collins, Jacqueline; Wilson, Rodgers; Fleck, David E; Corey, Kimberly B; Amicone, Jennifer; Adebimpe, Victor R; Strakowski, Stephen M (2004. ) Ethnicity and first-rank symptoms in patients with psychosis.Schizophrenia research, , 67 (2-3 ) ,207-12 More Information

Arnold, Lesley M; Strakowski, Stephen M; Schwiers, Michael L; Amicone, Jennifer; Fleck, David E; Corey, Kimberly B; Farrow, Jenni E (2004. ) Sex, ethnicity, and antipsychotic medication use in patients with psychosis.Schizophrenia research, , 66 (2-3 ) ,169-75 More Information

Barzman, Drew H; DelBello, Melissa P; Kowatch, Robert A; Gernert, Beth; Fleck, David E; Pathak, Sanjeev; Rappaport, Katherine; Delgado, Sergio V; Campbell, Pamela; Strakowski, Stephen M (2004. ) The effectiveness and tolerability of aripiprazole for pediatric bipolar disorders: a retrospective chart review.Journal of child and adolescent psychopharmacology, , 14 (4 ) ,593-600 More Information

Fleck, David E; Shear, Paula K; Zimmerman, Molly E; Getz, Glen E; Corey, Kimberly B; Jak, Amy; Lebowitz, Brian K; Strakowski, Stephen M (2003. ) Verbal memory in mania: effects of clinical state and task requirements. Bipolar disorders, , 5 (5 ) ,375-80

Strakowski, Stephen M; Keck, Paul E; Arnold, Lesley M; Collins, Jacqueline; Wilson, Rodgers M; Fleck, David E; Corey, Kimberly B; Amicone, Jennifer; Adebimpe, Victor R (2003. ) Ethnicity and diagnosis in patients with affective disorders. The Journal of clinical psychiatry, , 64 (7 ) ,747-54

Fleck, David E; Hendricks, Wendi L; DelBello, Melissa P; Strakowski, Stephen M (2002. ) Differential prescription of maintenance antipsychotics to African American and white patients with new-onset bipolar disorder. The Journal of clinical psychiatry, , 63 (8 ) ,658-64

Fleck, David E; Shear, Paula K; Strakowski, Stephen M (2002. ) A reevaluation of sustained attention performance in temporal lobe epilepsy. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, , 17 (4 ) ,399-405

Getz, Glen E; DelBello, Melissa P; Fleck, David E; Zimmerman, Molly E; Schwiers, Michael L; Strakowski, Stephen M (2002. ) Neuroanatomic characterization of schizoaffective disorder using MRI: a pilot study. Schizophrenia research, , 55 (1-2 ) ,55-9

Fleck, D E; Sax, K W; Strakowski, S M (2001. ) Reaction time measures of sustained attention differentiate bipolar disorder from schizophrenia. Schizophrenia research, , 52 (3 ) ,251-9

Getz, G E; Fleck, D E; Strakowski, S M (2001. ) Frequency and severity of religious delusions in Christian patients with psychosis. Psychiatry research, , 103 (1 ) ,87-91

Fleck, D E; Corey, K B; Strakowski, S M (2001. ) Symptom dimensions in acutely ill patients with affective, schizoaffective, and schizophrenic disorders. Schizophrenia research, , 50 (1-2 ) ,131-2

Wilder-Willis, K E; Sax, K W; Rosenberg, H L; Fleck, D E; Shear, P K; Strakowski, S M (2001. ) Persistent attentional dysfunction in remitted bipolar disorder. Bipolar disorders, , 3 (2 ) ,58-62

Strakowski, S M; Williams, J R; Sax, K W; Fleck, D E; DelBello, M P; Bourne, M L (2000. ) Is impaired outcome following a first manic episode due to mood-incongruent psychosis? .Journal of affective disorders, , 61 (1-2 ) ,87-94

Strakowski, S M; DelBello, M P; Fleck, D E; Arndt, S (2000. ) The impact of substance abuse on the course of bipolar disorder. Biological psychiatry, , 48 (6 ) ,477-85

Strakowski, S M; Williams, J R; Fleck, D E; Delbello, M P Eight-month functional outcome from mania following a first psychiatric hospitalization. Journal of psychiatric research, , 34 (3 ) ,193-200

Fleck, D E; Berch, D B; Shear, P K; Schefft, B K; Privitera, M D; Strakowski, S M (1999. ) Directed forgetting deficits in patients with temporal lobe epilepsy: an information processing perspective. Journal of the International Neuropsychological Society : JINS, , 5 (6 ) ,549-55

Invited Presentations

Adler, C.M., Strakowski, S.M., Fleck, D.E., & Brecher, M. (04-2005. ) Safety and tolerability of quetiapine in bipolar mania .Munich, Germany.

Barzman, D.H., DelBello, M.P, Lehmkuhl, H, Fleck, D.E., & Strakowski, S.M. (10-2005. ) The identification of risk and protective factors for offending behaviors in bipolar adolescents .Montreal, Quebec.

Moss, Q., Fleck, D.E., & Strakowski, S.M. (05-2006. ) The influence of religious affiliation on time to first treatment and hospitalization .Philadelphia, PA.

Allendorfer, J.B., Lamy, M., Eliassen, J.C., Adams, J., Mills, N.P., Adler, C.M., DelBello, M.P., Lee, J.H., Fleck, D.E., & Strakowski, S.M. (10-2006. ) Attentional and emotional networks differ in manic bipolars compared to healthy controls .Atlanta, GA.

Singh, M.K., Fleck, D.E., DelBello, M.P., Shear, P.K., & Strakowski, S.M. (10-2006. ) Attentional dysfunction in child offspring of bipolar parents: A preliminary report .San Diego, CA.

Heffner, J.L., Delbello, M.P., Fleck, D.E., Anthenelli, R.M., & Strakowski, S.M. (02-2007. ) Cigarette smoking among individuals with bipolar disorder: Association with ages at onset of alcohol and marijuana use .Austin, TX.

Gold, J.I., Vichinsky, E., Neumayr, l., Rule, R.R., Weiner, M.W., Muma, A., Eggleston, B., Lieff, S., Peterson, A., Feliu, M., Mosbach, P., Willen, E., Tucker, K., Crosby, L., Fleck, D., Rutledge, A., Rilling, L., Butler, D., McCleary, C., Armstrong D. (09-2007. ) NHLBI comprehensive sickle cell centers (CSCC) study of neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adult patients with sickle cell disease: Preliminary neuropsychological findings .Bethesda, MD.

Fleck, D.E., Eliassen, J.C., Durling, M., Adams, J., Lamy, M., Williams, K., & Strakowski, S.M. (12-2007. ) Manic distractibility and frontosubcortical processing: An fMRI study .Boca Raton, FL.

Kotwal, R., Fleck, D.E., Delbello, M.P., & Strakowski, S.M. (05-2008. ) Functional MRI of impulsivity in the mixed state of bipolar disorder: Relationship to suicidal behavior .Washington, DC.

Fleck, D.E., Eliassen, J.C., Adler, C.M., DelBello, M.P., Shear, P.K., Durling, M., Cerullo, M.A., Lamy, M., & Strakowski, S.M. (10-2008. ) Posttraumatic stress symptoms in youth with first episode bipolar disorder .Chicago, IL.

Nandagopal, J., Fleck, D.E., Strakowski S.M., & DelBello, M.P. (10-2008. ) Measurement of impulsivity in adolescents with bipolar disorder and ADHD .Chicago, IL.

DelBello, M.P., Adler, C.M., Fleck, D.E., & Strakowski S.M. (10-2008. ) Rates and predictors of outcome in first-episode manic bipolar adolescents .Chicago, IL.

Luckson, M., Snyder, R, & Fleck, D.E. (12-2008. ) Hypertension exacerbates mild cognitive impairment in adults with sickle cell disease .San Francisco, CA.

Heffner, J.L., Fleck, D.E., DelBello, M.P., Anthenelli, R.M., & Strakowski, S.M. (04-2009. ) Preliminary evidence that cigarette smoking predicts new-onset alcohol and cannabis use disorders following hospitalization for first-episode mania in adults and adolescents with bipolar I disorder .Dublin, Ireland.

Shear, P.K., Dawson, E.L., DelBello, M.P., Adler, C.M., Fleck, D.E., McElroy, S., & Strakowski, S.M. (08-2009. ) Nature and frequency of impulsive behaviors in healthy young adults .Boston, MA.

Shah, A.P., Fleck, D.E., Mills, N.P., & DelBello, M.P. (05-2010. ) Structural volumes of the cerebellar vermis in a pediatric bipolar population with comorbid ADHD .New Orleans, LA.

2003 -2007 Millennium Scholar University of Cincinnati College of Medicine, Cincinnati, OH

2005 Research Incentive Award Department of Psychiatry, University of Cincinnati, Cincinnati, OH

2005 Recognition for Extraordinary Achievement National Alliance for Research on Schizophrenia and Depression, New York, NY2005: Who’s Who in Science & Engineering, 5th ed., (first bio) Marquis Who’s Who, New Providence, NJ

2006 -2007 Faculty Award for Research Department of Psychiatry, University of Cincinnati, Cincinnati, OH

2007 Who’s Who in the World, 24th ed., (first bio) Marquis Who’s Who, New Providence, NJ

2007 Who’s Who of Emerging Leaders, 1st ed., (first bio) Marquis Who’s Who, New Providence, NJ

2007 -2009 Travel Grant, Central Society for Clinical Research Chicago, IL

Relevant link: http://www.cir.uc.edu/
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Research - UC Center for Imaging Research
PO Box 0583
Cincinnati  Ohio, 45267-0583
Phone: (513) 558-4940

Academic - Stetson Building
Suite 3200
Cincinnati  Ohio, 45219
Phone: 513-558-7700
david.fleck@uc.edu