David N. Franz, MD

Medical Degree: Ohio State University College of Medicine Columbus, OH,

Residency: Wright State University Dayton, OH,

Fellowship: Cincinnati Children's Hospital Medical Center Cincinnati, OH, (Neurology)

Peer Reviewed Publications

Greiner, Hansel M; Lynch, Elizabeth R; Fordyce, Steve; Agricola, Karen; Tudor, Cynthia; Franz, David Neal; Krueger, Darcy A  (2012). Vigabatrin for childhood partial-onset epilepsies. Pediatric neurology, 46 (2) , 83-8More Information

Tillema, Jan-Mendelt; Leach, James L; Krueger, Darcy A; Franz, David Neal  (2012). Everolimus alters white matter diffusion in tuberous sclerosis complex. NeurologyMore Information

Chung, Thomas K; Lynch, Elizabeth R; Fiser, Cheryl J; Nelson, Daniel A; Agricola, Karen; Tudor, Cynthia; Franz, David Neal; Krueger, Darcy A  (2011). Psychiatric comorbidity and treatment response in patients with tuberous sclerosis complex. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 23 (4) , 263-9

Franz, David Neal  (2011). Everolimus: an mTOR inhibitor for the treatment of tuberous sclerosis. Expert review of anticancer therapy, 11 (8) , 1181-92More Information

Tiberio, Dana; Franz, David N; Phillips, John R  (2011). Regression of a cardiac rhabdomyoma in a patient receiving everolimus. Pediatrics, 127 (5) , e1335-7More Information

Dabora, Sandra L; Franz, David Neal; Ashwal, Stephen; Sagalowsky, Arthur; DiMario, Francis J; Miles, Daniel; Cutler, Drew; Krueger, Darcy; Uppot, Raul N; Rabenou, Rahmin; Camposano, Susana; Paolini, Jan; Fennessy, Fiona; Lee, Nancy; Woodrum, Chelsey; Manola, Judith; Garber, Judy; Thiele, Elizabeth A  (2011). Multicenter phase 2 trial of sirolimus for tuberous sclerosis: kidney angiomyolipomas and other tumors regress and VEGF- D levels decrease. PloS one, 6 (9) , e23379More Information

Krueger, Darcy A; Care, Marguerite M; Holland, Katherine; Agricola, Karen; Tudor, Cynthia; Mangeshkar, Prajakta; Wilson, Kimberly A; Byars, Anna; Sahmoud, Tarek; Franz, David Neal  (2010). Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. The New England journal of medicine, 363 (19) , 1801-11More Information

Qin, Wei; Chan, Jennifer A; Vinters, Harry V; Mathern, Gary W; Franz, David N; Taillon, Bruce E; Bouffard, Pascal; Kwiatkowski, David J  (2010). Analysis of TSC cortical tubers by deep sequencing of TSC1, TSC2 and KRAS demonstrates that small second-hit mutations in these genes are rare events. Brain pathology (Zurich, Switzerland), 20 (6) , 1096-105More Information

Franz, D N; Bissler, J J; McCormack, F X  (2010). Tuberous sclerosis complex: neurological, renal and pulmonary manifestations. Neuropediatrics, 41 (5) , 199-208More Information

Young, Lisa R; Vandyke, Rhonda; Gulleman, Peter M; Inoue, Yoshikazu; Brown, Kevin K; Schmidt, Laura S; Linehan, W Marston; Hajjar, Fuad; Kinder, Brent W; Trapnell, Bruce C; Bissler, John J; Franz, David N; McCormack, Francis X  (2010). Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases. Chest, 138 (3) , 674-81More Information

Young, Lisa R; Franz, David N; Nagarkatte, Preeti; Fletcher, Christopher D M; Wikenheiser-Brokamp, Kathryn A; Galsky, Matthew D; Corbridge, Thomas C; Lam, Anna P; Gelfand, Michael J; McCormack, Francis X  (2009). Utility of [18F]2-fluoro-2-deoxyglucose-PET in sporadic and tuberous sclerosis-associated lymphangioleiomyomatosis. Chest, 136 (3) , 926-33More Information

Schmithorst, Vincent J; Altes, Talissa A; Young, Lisa R; Franz, David N; Bissler, John J; McCormack, Francis X; Dardzinski, Bernard J; Brody, Alan S  (2009). Automated algorithm for quantifying the extent of cystic change on volumetric chest CT: initial results in Lymphangioleiomyomatosis. AJR. American journal of roentgenology, 192 (4) , 1037-44More Information

Franz, D N; de Vries, P J; Crino, P B  (2009). Giant cell astrocytomas in tuberous sclerosis complex. Archives of disease in childhood, 94 (1) , 75-6

Bissler, John J; McCormack, Francis X; Young, Lisa R; Elwing, Jean M; Chuck, Gail; Leonard, Jennifer M; Schmithorst, Vincent J; Laor, Tal; Brody, Alan S; Bean, Judy; Salisbury, Shelia; Franz, David N  (2008). Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. The New England journal of medicine, 358 (2) , 140-51More Information

Krueger, Darcy A; Franz, David N  (2008). Current management of tuberous sclerosis complex. Paediatric drugs, 10 (5) , 299-313

Ma, Li; Teruya-Feldstein, Julie; Bonner, Pauline; Bernardi, Rosa; Franz, David Neal; Witte, David; Cordon-Cardo, Carlos; Pandolfi, Pier Paolo  (2007). Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer. Cancer research, 67 (15) , 7106-12More Information

Franz, David Neal  (2007). mTOR in tuberous sclerosis and other neurological disorders. Epilepsia, 48 (8) , 1630-1; author replyMore Information

Madhavan, Deepak; Schaffer, Sarah; Yankovsky, Alexei; Arzimanoglou, Alexis; Renaldo, Florence; Zaroff, Charles M; LaJoie, Josiane; Weiner, Howard L; Andermann, Eva; Franz, David N; Leonard, Jennifer; Connolly, Mary; Cascino, Greg D; Devinsky, Orrin  (2007). Surgical outcome in tuberous sclerosis complex: a multicenter survey. Epilepsia, 48 (8) , 1625-8More Information

Levine, N B; Collins, J; Franz, D N; Crone, K R  (2006). Gradual formation of an operative corridor by balloon dilation for resection of subependymal giant cell astrocytomas in children with tuberous sclerosis: specialized minimal access technique of balloon dilation. Minimally invasive neurosurgery : MIN, 49 (5) , 317-20More Information

Pranzatelli, Michael R; Tate, Elizabeth D; Travelstead, Anna L; Barbosa, Jerry; Bergamini, Robert A; Civitello, Lucy; Franz, David N; Greffe, Brian S; Hanson, Robin D; Hurwitz, Craig A; Kalinyak, Karen A; Kelfer, Howard; Khakoo, Yasmin; Mantovani, John F; Nicholson, Stacy H; Sanders, Joann M; Wegner, Stephen  (2006). Rituximab (anti-CD20) adjunctive therapy for opsoclonus-myoclonus syndrome. Journal of pediatric hematology/oncology, 28 (9) , 585-93More Information

Franz, David Neal; Leonard, Jennifer; Tudor, Cynthia; Chuck, Gail; Care, Marguerite; Sethuraman, Gopalan; Dinopoulos, Argirios; Thomas, George; Crone, Kerry R  (2006). Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Annals of neurology, 59 (3) , 490-8More Information

Collins, James J; Tudor, Cynthia; Leonard, Jennifer M; Chuck, Gail; Franz, David Neal  (2006). Levetiracetam as adjunctive antiepileptic therapy for patients with tuberous sclerosis complex: a retrospective open-label trial. Journal of child neurology, 21 (1) , 53-7

Tinkle, Brad T; Schorry, Elizabeth K; Franz, David N; Crone, Kerry R; Saal, Howard M  (2005). Epidemiology of hemimegalencephaly: a case series and review. American journal of medical genetics. Part A, 139 (3) , 204-11More Information

Tang, Yang; Schapiro, Mark B; Franz, David N; Patterson, Bonnie J; Hickey, Francis J; Schorry, Elizabeth K; Hopkin, Robert J; Wylie, Matthew; Narayan, Tina; Glauser, Tracy A; Gilbert, Donald L; Hershey, Andrew D; Sharp, Frank R  (2004). Blood expression profiles for tuberous sclerosis complex 2, neurofibromatosis type 1, and Down's syndrome. Annals of neurology, 56 (6) , 808-14More Information

Franz, David Neal  (2004). Non-neurologic manifestations of tuberous sclerosis complex. Journal of child neurology, 19 (9) , 690-8

Pranzatelli, M R; Travelstead, A L; Tate, E D; Allison, T J; Moticka, E J; Franz, D N; Nigro, M A; Parke, J T; Stumpf, D A; Verhulst, S J  (2004). B- and T-cell markers in opsoclonus-myoclonus syndrome: immunophenotyping of CSF lymphocytes. Neurology, 62 (9) , 1526-32

Roberts, P S; Dabora, S; Thiele, E A; Franz, D N; Jozwiak, S; Kwiatkowski, D J  (2004). Somatic mosaicism is rare in unaffected parents of patients with sporadic tuberous sclerosis. Journal of medical genetics, 41 (5) , e69

Walz, Nicolay Chertkoff; Byars, Anna Weber; Egelhoff, John C; Franz, David Neal  (2002). Supratentorial tuber location and autism in tuberous sclerosis complex. Journal of child neurology, 17 (11) , 830-2

Jones, Blaise V; Tomsick, Thomas A; Franz, David N  (2002). Guglielmi detachable coil embolization of a giant midbasilar aneurysm in a 19-month-old patient. AJNR. American journal of neuroradiology, 23 (7) , 1145-8

Roberts, Penelope S; Chung, Joon; Jozwiak, Sergiusz; Dabora, Sandra L; Franz, David N; Thiele, Elizabeth A; Kwiatkowski, David J  (2002). SNP identification, haplotype analysis, and parental origin of mutations in TSC2. Human genetics, 111 (1) , 96-101More Information

Franz, David Neal  (2002). Meningiomas in women with lymphangioleiomyomatosis. JAMA : the journal of the American Medical Association, 287 (11) , 1397-8

McCormack, Francis; Brody, Alan; Meyer, Christopher; Leonard, Jennifer; Chuck, Gail; Dabora, Sandra; Sethuraman, Gopalan; Colby, Thomas V; Kwiatkowski, David J; Franz, David N  (2002). Pulmonary cysts consistent with lymphangioleiomyomatosis are common in women with tuberous sclerosis: genetic and radiographic analysis. Chest, 121 (3 Suppl) , 61S

Adams, Brian B; Vargus-Adams, Jilda N; Franz, David N; Kinnett, Douglas G  (2002). Hyperhidrosis in pediatric spinal cord injury: a case report and gabapentin therapy. Journal of the American Academy of Dermatology, 46 (3) , 444-6

Franz, D N; Brody, A; Meyer, C; Leonard, J; Chuck, G; Dabora, S; Sethuraman, G; Colby, T V; Kwiatkowski, D J; McCormack, F X  (2001). Mutational and radiographic analysis of pulmonary disease consistent with lymphangioleiomyomatosis and micronodular pneumocyte hyperplasia in women with tuberous sclerosis. American journal of respiratory and critical care medicine, 164 (4) , 661-8

Franz, D N; Tudor, C; Leonard, J; Egelhoff, J C; Byars, A; Valerius, K; Sethuraman, G  (2001). Lamotrigine therapy of epilepsy in tuberous sclerosis. Epilepsia, 42 (7) , 935-40

Weber Byars, A M; McKellop, J M; Gyato, K; Sullivan, T; Franz, D N  (2001). Metachromatic leukodystrophy and nonverbal learning disability: neuropsychological and neuroradiological findings in heterozygous carriers. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence, 7 (1) , 54-8

Dabora, S L; Jozwiak, S; Franz, D N; Roberts, P S; Nieto, A; Chung, J; Choy, Y S; Reeve, M P; Thiele, E; Egelhoff, J C; Kasprzyk-Obara, J; Domanska-Pakiela, D; Kwiatkowski, D J  (2001). Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. American journal of human genetics, 68 (1) , 64-80More Information

Weber, A M; Egelhoff, J C; McKellop, J M; Franz, D N  (2000). Autism and the cerebellum: evidence from tuberous sclerosis. Journal of autism and developmental disorders, 30 (6) , 511-7

Best, T H; Franz, D N; Gilbert, D L; Nelson, D P; Epstein, M R  (2000). Cardiac complications in pediatric patients on the ketogenic diet. Neurology, 54 (12) , 2328-30

Franz, D N; Glauser, T A; Tudor, C; Williams, S  (2000). Topiramate therapy of epilepsy associated with Angelman's syndrome. Neurology, 54 (5) , 1185-8

Franz, D N  (1998). Diagnosis and management of tuberous sclerosis complex. Seminars in pediatric neurology, 5 (4) , 253-68

Franz, D N  (1993). Tremor in childhood. Pediatric annals, 22 (1) , 60-4

Wong, K C; Franz, D N; Tseng, J  (1989). Clinical pharmacology of alpha2-agonist and beta-adrenergic blocker. Ma zui xue za zhi = Anaesthesiologica Sinica, 27 (4) , 357-62

Franz, D N; Peterson, R G; Madsen, P W; Sangdee, C  (1987). Enhancement of central transmission to sympathetic preganglionic neurons by phosphodiesterase inhibitors and its prevention by clonidine. Journal of the autonomic nervous system, 19 (3) , 199-209

Sangdee, C; Franz, D N  (1983). Evidence for inhibition of sympathetic preganglionic neurons by bulbospinal epinephrine pathways. Neuroscience letters, 37 (2) , 167-73

Liston, D R; Franz, D N; Gibb, J W  (1982). Biochemical evidence for alteration of neostriatal dopaminergic function by 5,7-dihydroxytryptamine. Journal of neurochemistry, 38 (5) , 1329-35

Franz, D N; Hare, D B; McCloskey, K L  (1982). Spinal sympathetic neurons: possible sites of opiate-withdrawal suppression by clonidine. Science (New York, N.Y.), 215 (4540) , 1643-5

Franz, D N; Madsen, P W  (1982). Differential sensitivity of four central sympathetic pathways to depression by clonidine. European journal of pharmacology, 78 (1) , 53-9

Franz, D N; Madsen, P W  (1982). Clonidine prevents enhancement of spinal sympathetic transmission by phosphodiesterase inhibitors. Neuroscience letters, 28 (2) , 211-6

Franz, D N; Madsen, P W; Peterson, R G; Sangdee, C  (1982). Functional roles of monoaminergic pathways to sympathetic preganglionic neurons. Clinical and experimental hypertension. Part A, Theory and practice, 4 (4-5) , 543-62

Tramposch, A; Sangdee, C; Franz, D N; Karler, R; Turkanis, S A  (1981). Cannabinoid-induced enhancement and depression of cat monosynaptic reflexes. Neuropharmacology, 20 (6) , 617-21

Madsen, P W; Hare, B D; Sangdee, C; Franz, D N  (1981). Contrasting effects of clonidine and 5-hydroxytryptophan on spinal sympathetic pathways. Clinical and experimental hypertension, 3 (6) , 1151-63

Thomson, T D; Franz, D N  (1981). Amino acid and monoamine inhibition of sacral parasympathetic preganglionic neurons. Progress in clinical and biological research, 68, 181-9

Sangdee, C; Franz, D N  (1980). Lithium enhancement of central 5-HT transmission induced by 5-HT precursors. Biological psychiatry, 15 (1) , 59-75

Sangdee, C; Franz, D N  (1979). Enhancement of central norepinephrine and 5-hydroxytryptamine transmission by tricyclic antidepressants. A comparison. Psychopharmacology, 62 (1) , 9-16

Franz, D N; Hare, B D; Neumayr, R J  (1978). Depression of sympathetic preganglionic neurons by clonidine: evidence for stimulation of 5-HT receptors. Clinical and experimental hypertension, 1 (1) , 115-40

Sangdee, C; Franz, D N  (1978). Lithium-induced enhancement of 5-HT transmission at a central synapse. Communications in psychopharmacology, 2 (3) , 191-8

Franz, D N; Neumayr, R J; Hare, B D  (1977). L-dopa-induced hypotension: depression of spinal sympathetic neurons by release of 5-hydroxytryptamine. Advances in experimental medicine and biology, 90, 219-232

Neumayr, R J; Hare, B D; Franz, D N  (1974). Evidence for bulbospinal control of sympathetic preganglionic neurons by monoaminergic pathways. Life sciences, 14 (4) , 793-806

Franz, D N; Perry, R S  (1974). Mechanisms for differential block among single myelinated and non-myelinated axons by procaine. The Journal of physiology, 236 (1) , 193-210

Hare, B D; Neumayr, R J; Franz, D N  (1972). Opposite effects of L-dopa and 5-HTP on spinal sympathetic reflexes. Nature, 239 (5371) , 336-7

Downes, H; Franz, D N  (1971). Effects of a convulsant barbiturate on dorsal root ganglion cells and dorsal root discharges. The Journal of pharmacology and experimental therapeutics, 179 (3) , 660-70

Brown, A G; Franz, D N  (1970). Patterns of response in spinocervical tract neurones to different stimuli of long duration. Brain research, 17 (1) , 156-60

Brown, A G; Franz, D N  (1969). Responses of spinocervical tract neurones to natural stimulation of identified cutaneous receptors. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale, 7 (3) , 231-49

Franz, D N; Iggo, A  (1968). Dorsal root potentials and ventral root reflexes evoked by nonmyelinated fibers. Science (New York, N.Y.), 162 (3858) , 1140-2

Franz, D N; Iggo, A  (1968). Conduction failure in myelinated and non-myelinated axons at low temperatures. The Journal of physiology, 199 (2) , 319-45

Chambers, M R; Franz, D N  (1968). Single unit dissection and identification of afferent nerve fibres. The Journal of physiology, 195 (2) , 11P

Franz, D N; Evans, M H; Perl, E R  (1966). Characteristics of viscerosympathetic reflexes in the spinal cat. The American journal of physiology, 211 (6) , 1292-8

Tate, Elizabeth D; Pranzatelli, Michael R; Verhulst, Steven J; Markwell, Stephen J; Franz, David Neal; Graf, William D; Joseph, S Anne; Khakoo, Yasmin N; Lo, Warren D; Mitchell, Wendy G; Sivaswamy, Lalitha  (2012). Active comparator-controlled, rater-blinded study of corticotropin-based immunotherapies for opsoclonus-myoclonus syndrome. Journal of child neurology, 27 (7) , 875-84More Information

Franz, David Neal; Weiss, Brian D  (2012). Molecular therapies for tuberous sclerosis and neurofibromatosis. Current neurology and neuroscience reports, 12 (3) , 294-301More Information

Arya, Ravindra; Tenney, Jeffrey R; Horn, Paul S; Greiner, Hansel M; Holland, Katherine D; Leach, James L; Gelfand, Michael J; Rozhkov, Leonid; Fujiwara, Hisako; Rose, Douglas F; Franz, David N; Mangano, Francesco T  (2015). Long-term outcomes of resective epilepsy surgery after invasive presurgical evaluation in children with tuberous sclerosis complex and bilateral multiple lesions. Journal of neurosurgery. Pediatrics, 15 (1) , 26-33More Information

Franz, David Neal; Belousova, Elena; Sparagana, Steven; Bebin, E Martina; Frost, Michael; Kuperman, Rachel; Witt, Olaf; Kohrman, Michael H; Flamini, J Robert; Wu, Joyce Y; Curatolo, Paolo; de Vries, Petrus J; Berkowitz, Noah; Anak, Oezlem; Niolat, Julie; Jozwiak, Sergiusz  (2014). Everolimus for subependymal giant cell astrocytoma in patients with tuberous sclerosis complex: 2-year open-label extension of the randomised EXIST-1 study. The Lancet. Oncology, 15 (13) , 1513-20More Information

Kingswood, J Chris; Jozwiak, Sergiusz; Belousova, Elena D; Frost, Michael D; Kuperman, Rachel A; Bebin, E Martina; Korf, Bruce R; Flamini, J Robert; Kohrman, Michael H; Sparagana, Steven P; Wu, Joyce Y; Brechenmacher, Thomas; Stein, Karen; Berkowitz, Noah; Bissler, John J; Franz, David N  (2014). The effect of everolimus on renal angiomyolipoma in patients with tuberous sclerosis complex being treated for subependymal giant cell astrocytoma: subgroup results from the randomized, placebo-controlled, Phase 3 trial EXIST-1. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29 (6) , 1203-10More Information

Krueger, Darcy; Wilfong, Angus; Franz, David N  (2014). Reply: To PMID 23798472. Annals of neurology, 75 (1) , 164-5More Information

Roth, Jonathan; Roach, E Steve; Bartels, Ute; Jó?wiak, Sergiusz; Koenig, Mary Kay; Weiner, Howard L; Franz, David N; Wang, Henry Z  (2013). Subependymal giant cell astrocytoma: diagnosis, screening, and treatment. Recommendations from the International Tuberous Sclerosis Complex Consensus Conference 2012. Pediatric neurology, 49 (6) , 439-44More Information

Krueger, Darcy A; Wilfong, Angus A; Holland-Bouley, Katherine; Anderson, Anne E; Agricola, Karen; Tudor, Cindy; Mays, Maxwell; Lopez, Christina M; Kim, Mi-Ok; Franz, David Neal  (2013). Everolimus treatment of refractory epilepsy in tuberous sclerosis complex. Annals of neurology, 74 (5) , 679-87More Information

Wiegand, Gert; May, Theodor W; Ostertag, Philipp; Boor, Rainer; Stephani, Ulrich; Franz, David Neal  (2013). Everolimus in tuberous sclerosis patients with intractable epilepsy: a treatment option?. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 17 (6) , 631-8More Information

Wirrell, Elaine C; Laux, Linda; Franz, David N; Sullivan, Joseph; Saneto, Russell P; Morse, Richard P; Devinsky, Orrin; Chugani, Harry; Hernandez, Angel; Hamiwka, Lorie; Mikati, Mohamad A; Valencia, Ignacio; Le Guern, Marie-Emmanuelle; Chancharme, Laurent; de Menezes, Marcio Sotero  (2013). Stiripentol in Dravet syndrome: results of a retrospective U.S. study. Epilepsia, 54 (9) , 1595-604More Information

Cudzilo, Corey J; Szczesniak, Rhonda D; Brody, Alan S; Rattan, Mantosh S; Krueger, Darcy A; Bissler, John J; Franz, David N; McCormack, Francis X; Young, Lisa R  (2013). Lymphangioleiomyomatosis screening in women with tuberous sclerosis. Chest, 144 (2) , 578-85More Information

Agricola, Karen; Tudor, Cindy; Krueger, Darcy; Franz, David Neal  (2013). Nursing implications for the lifelong management of tuberous sclerosis complex. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 45 (4) , 226-42More Information

Franz, David Neal; Agricola, Karen D; Tudor, Cynthia A; Krueger, Darcy A  (2013). Everolimus for tumor recurrence after surgical resection for subependymal giant cell astrocytoma associated with tuberous sclerosis complex. Journal of child neurology, 28 (5) , 602-7More Information

Franz, David Neal  (2013). Everolimus for astrocytomas in tuberous sclerosis - author's reply. Lancet (London, England), 381 (9874) , 1275More Information

Krueger, Darcy A; Care, Marguerite M; Agricola, Karen; Tudor, Cindy; Mays, Maxwell; Franz, David Neal  (2013). Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma. Neurology, 80 (6) , 574-80More Information

Franz, David Neal; Belousova, Elena; Sparagana, Steven; Bebin, E Martina; Frost, Michael; Kuperman, Rachel; Witt, Olaf; Kohrman, Michael H; Flamini, J Robert; Wu, Joyce Y; Curatolo, Paolo; de Vries, Petrus J; Whittemore, Vicky H; Thiele, Elizabeth A; Ford, James P; Shah, Gaurav; Cauwel, Helene; Lebwohl, David; Sahmoud, Tarek; Jozwiak, Sergiusz  (2013). Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial. Lancet (London, England), 381 (9861) , 125-32More Information

Franz, David Neal  (2013). Everolimus in the treatment of subependymal giant cell astrocytomas, angiomyolipomas, and pulmonary and skin lesions associated with tuberous sclerosis complex. Biologics : targets & therapy, 7, 211-21More Information

Malinowska, Izabela A; Lee, Nancy; Kumar, Vidhya; Thiele, Elizabeth A; Franz, David Neal; Ashwal, Stephen; Sagalowsky, Arthur; Dimario, Francis J; Cutler, Drew; Krueger, Darcy; Camposano, Susana; Paolini, Jan; Dabora, Sandra L  (2013). Similar trends in serum VEGF-D levels and kidney angiomyolipoma responses with longer duration sirolimus treatment in adults with tuberous sclerosis. PloS one, 8 (2) , e56199More Information

Academic - Cincinnati Children's Hospital Medical Center
Cincinnati  Ohio, 45229
Phone: 513-636-4222
david.franz@cchmc.org