Jason Frischer

Jason Frischer , MD

Professor of Clinical-Affiliate

Director, Peña Colorectal Center, CCHMC

Division of Pediatric Surgery
Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati, Ohio 45229
Phone 513-636-8318
Email jason.frischer@cchmc.org

Education

Bachelor's Degree: Cornell University 1995 (Nutritional Sciences)

Medical Degree: SUNY Downstate Medical Center 1999

Pediatric Surgery Research/ECMO Fellowship: Columbia University/Children's Hospital of New York 2003 ( )

General Surgery Residency: Mount Sinai School of Medicine 2006

Pediatric Surgery Residency: Columbia University/Children’s Hospital of New York 2008

Research and Practice Interests

Colorectal Surgery, Inflammatory Bowel Disease, Surgical Oncology, Minimally Invasive Surgery, ECMO, Neonatal Surgery

Publications

Peer Reviewed Publications

Fernandez, Emilio; Bischoff, Andrea; Dickie, Belinda H; Frischer, Jason; Hall, Jennifer; Peña, Alberto (2014. ) Esophageal atresia in patients with anorectal malformations.Pediatric surgery international, , 30 (8 ) ,767-71 More Information

Bischoff, Andrea; Frischer, Jason; Dickie, Belinda H; Peña, Alberto (2014. ) Anorectal malformation without fistula: a defect with unique characteristics.Pediatric surgery international, , 30 (8 ) ,763-6 More Information

Knod, Jennifer Leslie; Crawford, Kelly; Dusing, Mary; Frischer, Jason S (2014. ) Mouse strain influences angiogenic response to dextran sodium sulfate-induced colitis.The Journal of surgical research, , 190 (1 ) ,47-54 More Information

Merrow, Arnold C; Frischer, Jason S; Lucky, Anne W (2013. ) Pyloric atresia with epidermolysis bullosa: fetal MRI diagnosis with postnatal correlation.Pediatric radiology, , 43 (12 ) ,1656-61 More Information

Eradi, Balgopal; Hamrick, Miller; Bischoff, Andrea; Frischer, Jason S; Helmrath, Michael; Hall, Jennifer; Peña, Alberto; Levitt, Marc A (2013. ) The role of a colon resection in combination with a Malone appendicostomy as part of a bowel management program for the treatment of fecal incontinence.Journal of pediatric surgery, , 48 (11 ) ,2296-300 More Information

Landis, Melissa W; Butler, Dawn; Lim, Foong Yen; Keswani, Sundeep; Frischer, Jason; Haberman, Beth; Kingma, Paul S (2013. ) Octreotide for chylous effusions in congenital diaphragmatic hernia.Journal of pediatric surgery, , 48 (11 ) ,2226-9 More Information

Knod, Leslie; Donovan, Eileen C; Chernoguz, Artur; Crawford, Kelly M; Dusing, Mary R; Frischer, Jason S (2013. ) Vascular endothelial growth factor receptor-2 inhibition in experimental murine colitis.The Journal of surgical research, , 184 (1 ) ,101-7 More Information

Keswani, Sundeep G; Balaji, Swathi; Le, Louis D; Leung, Alice; Parvadia, Jignesh K; Frischer, Jason; Yamano, Seiichi; Taichman, Norton; Crombleholme, Timothy M Role of salivary vascular endothelial growth factor (VEGF) in palatal mucosal wound healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , 21 (4 ) ,554-62 More Information

Knod, J Leslie; Garrison, Aaron P; Frischer, Jason S; Dickie, Belinda (2013. ) Foregut duplication cyst associated with esophageal atresia and tracheoesophageal fistula: a case report and literature review.Journal of pediatric surgery, , 48 (5 ) ,E5-7 More Information

Currier, Mark A; Eshun, Francis K; Sholl, Allyson; Chernoguz, Artur; Crawford, Kelly; Divanovic, Senad; Boon, Louis; Goins, William F; Frischer, Jason S; Collins, Margaret H; Leddon, Jennifer L; Baird, William H; Haseley, Amy; Streby, Keri A; Wang, Pin-Yi; Hendrickson, Brett W; Brekken, Rolf A; Kaur, Balveen; Hildeman, David; Cripe, Timothy P (2013. ) VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells.Molecular therapy : the journal of the American Society of Gene Therapy, , 21 (5 ) ,1014-23 More Information

Chernoguz, Artur; Crawford, Kelly; Donovan, Eileen; Vandersall, Abbey; Berglund, Caroline; Cripe, Timothy P; Frischer, Jason S (2012. ) EGFR inhibition fails to suppress vascular proliferation and tumor growth in a Ewing's sarcoma model.The Journal of surgical research, , 173 (1 ) ,1-9 More Information

Chernoguz, Artur; Crawford, Kelly; Vandersall, Abbey; Rao, Marepalli; Willson, Tara; Denson, Lee A; Frischer, Jason S (2012. ) Pretreatment with anti-VEGF therapy may exacerbate inflammation in experimental acute colitis.Journal of pediatric surgery, , 47 (2 ) ,347-54 More Information

Barnett, Sean J; Frischer, Jason S; Gaskey, John A; Ryckman, Frederick C; von Allmen, Daniel (2012. ) Pediatric hernia repair: 1-stop shopping.Journal of pediatric surgery, , 47 (1 ) ,213-6 More Information

Le, Louis D; Keswani, Sundeep G; Biesiada, Jacek; Lim, Foong-Yen; Kingma, Paul S; Haberman, Beth E; Frischer, Jason; Habli, Mounira; Crombleholme, Timothy M (2012. ) The congenital diaphragmatic hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic hernia.Journal of pediatric surgery, , 47 (1 ) ,57-62 More Information

Lawal, Taiwo A; Falcone, Richard A; von Allmen, Daniel; Denson, Lee A; Levitt, Marc A; Warner, Brad W; Frischer, Jason S (2011. ) The utility of routine pouchogram before ileostomy reversal in children and adolescents following ileal pouch anal anastomosis.Journal of pediatric surgery, , 46 (6 ) ,1222-5 More Information

Lee, Timothy C; Lim, Foong Y; Keswani, Sundeep G; Frischer, Jason S; Haberman, Beth; Kingma, Paul S; Habli, Mounira; Jaekle, Ronald K; Sharp, Gina; Kline-Fath, Beth; Rubio, Eva I; Calvo, Maria; Guimaraes, Carolina; Crombleholme, Timothy M (2011. ) Late gestation fetal magnetic resonance imaging-derived total lung volume predicts postnatal survival and need for extracorporeal membrane oxygenation support in isolated congenital diaphragmatic hernia.Journal of pediatric surgery, , 46 (6 ) ,1165-71 More Information

Browne, Andrew W; Leddon, Jennifer L; Currier, Mark A; Williams, Jon P; Frischer, Jason S; Collins, Margaret H; Ahn, Chong H; Cripe, Timothy P (2011. ) Cancer screening by systemic administration of a gene delivery vector encoding tumor-selective secretable biomarker expression.PloS one, , 6 (5 ) ,e19530 More Information

Keswani, Sundeep G; Le, Louis D; Morris, Lee M; Lim, Foong-Yen; Katz, Anna B; Ghobril, Nabil; Habli, Mounira; Frischer, Jason S; Crombleholme, Timothy M (2011. ) Submucosal gland development in the human fetal trachea xenograft model: implications for fetal gene therapy.Journal of pediatric surgery, , 46 (1 ) ,33-8 More Information

Lawal, Taiwo A; Frischer, Jason S; Falcone, Richard A; Chatoorgoon, Kaveer; Denson, Lee A; Levitt, Marc A (2010. ) The transanal approach with laparoscopy or laparotomy for the treatment of rectal strictures in Crohn's disease.Journal of laparoendoscopic & advanced surgical techniques. Part A, , 20 (9 ) ,791-5 More Information

Bischoff, Andrea; Gupta, Anita; D'Mello, Sharon; Mezoff, Adam; Podberesky, Daniel; Barnett, Sean; Keswani, Sundeep; Frischer, Jason S (2010. ) Crohn's disease limited to the appendix: a case report in a pediatric patient.Pediatric surgery international, , 26 (11 ) ,1125-8 More Information

Vuletin, Jose F; Lim, Foong-Yen; Cnota, James; Kline-Fath, Beth; Salisbury, Shelia; Haberman, Beth; Kingma, Paul; Frischer, Jason; Crombleholme, Timothy (2010. ) Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia.Journal of pediatric surgery, , 45 (4 ) ,703-8 More Information

Dauplaise, Derrick J N; Barnett, Sean J; Frischer, Jason S; Wong, Hector R (2010. ) Decompressive abdominal laparotomy for abdominal compartment syndrome in an unengrafted bone marrow recipient with septic shock.Critical care research and practice, , 2010 , More Information

Ruiz-Elizalde, Alejandro R; Frischer, Jason S; Cowles, Robert A (2009. ) Button-loop feeding jejunostomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, , 13 (7 ) ,1376-8 More Information

Ruiz-Elizalde, Alejandro R; Haley, Mary Jo; Fisher, Jason C; Frischer, Jason S; Zitsman, Jeffrey L (2009. ) Gastric tube-pericardial fistula: a remote complication of esophageal replacement for long gap esophageal atresia.Journal of pediatric surgery, , 44 (7 ) ,1440-2 More Information

Kadenhe-Chiweshe, Angela; Papa, Joey; McCrudden, Kimberly W; Frischer, Jason; Bae, Jae-O; Huang, Jianzhong; Fisher, Jason; Lefkowitch, Jay H; Feirt, Nikki; Rudge, John; Holash, Jocelyn; Yancopoulos, George D; Kandel, Jessica J; Yamashiro, Darrell J (2008. ) Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation.Molecular cancer research : MCR, , 6 (1 ) ,1-9 More Information

Lee, Alice; Frischer, Jason; Serur, Anna; Huang, Jianzhong; Bae, Jae-O; Kornfield, Zev Noah; Eljuga, Lucy; Shawber, Carrie J; Feirt, Nikki; Mansukhani, Mahesh; Stempak, Diana; Baruchel, Sylvain; Glade Bender, Julia; Kandel, Jessica J; Yamashiro, Darrell J (2006. ) Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling.Cancer research, , 66 (8 ) ,4378-84 More Information

Bae, Jae-O; Frischer, Jason S; Waich, Margarita; Addonizio, Linda J; Lazar, Eric L; Stolar, Charles J H (2005. ) Extracorporeal membrane oxygenation in pediatric cardiac transplantation.Journal of pediatric surgery, , 40 (6 ) ,1051-6; discussion 1 More Information

Frischer, Jason S; Huang, Jianzhong; Serur, Anna; Kadenhe-Chiweshe, Angela; McCrudden, Kimberly W; O'Toole, Kathleen; Holash, Jocelyn; Yancopoulos, George D; Yamashiro, Darrell J; Kandel, Jessica J (2004. ) Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature. International journal of oncology, , 25 (3 ) ,549-53

Frischer, Jason S; Huang, Jianzhong; Serur, Anna; Kadenhe, Angela; Yamashiro, Darrell J; Kandel, Jessica J (2004. ) Biomolecular markers and involution of hemangiomas. Journal of pediatric surgery, , 39 (3 ) ,400-4

Huang, Jianzhong; Frischer, Jason S; New, Tamara; Kim, Eugene S; Serur, Anna; Lee, Alice; Kadenhe-Chiwishe, Angela; Pollyea, Daniel A; Yokoi, Akiko; Holash, Jocelyn; Yancopoulos, George D; Kandel, Jessica J; Yamashiro, Darrell J (2004. ) TNP-470 promotes initial vascular sprouting in xenograft tumors. Molecular cancer therapeutics, , 3 (3 ) ,335-43

Kaicker, Shipra; McCrudden, Kimberly W; Beck, Leal; New, Tamara; Huang, Jianzhong; Frischer, Jason S; Serur, Anna; Kadenhe-Chiweshe, Angela; Yokoi, Akiko; Kandel, Jessica J; Yamashiro, Darrell J (2003. ) Thalidomide is anti-angiogenic in a xenograft model of neuroblastoma. International journal of oncology, , 23 (6 ) ,1651-5

Yokoi, Akiko; McCrudden, Kimberly W; Huang, Jianzhong; Kim, Eugene S; Soffer, Samuel Z; Frischer, Jason S; Serur, Anna; New, Tamara; Yuan, Jenny; Mansukhani, Mahesh; O'toole, Kathleen; Yamashiro, Darrell J; Kandel, Jessica J (2003. ) Human epidermal growth factor receptor signaling contributes to tumor growth via angiogenesis in her2/neu-expressing experimental Wilms' tumor. Journal of pediatric surgery, , 38 (11 ) ,1569-73

Huang, Jianzhong; Frischer, Jason S; Serur, Anna; Kadenhe, Angela; Yokoi, Akiko; McCrudden, Kimberly W; New, Tamara; O'Toole, Kathleen; Zabski, Stephanie; Rudge, John S; Holash, Jocelyn; Yancopoulos, George D; Yamashiro, Darrell J; Kandel, Jessica J (2003. ) Regression of established tumors and metastases by potent vascular endothelial growth factor blockade.Proceedings of the National Academy of Sciences of the United States of America, , 100 (13 ) ,7785-90 More Information

McCrudden, Kimberly W; Hopkins, Benjamin; Frischer, Jason; Novikov, Anna; Huang, Jianzhong; Kadenhe, Angela; New, Tamara; Yokoi, Akiko; Yamashiro, Darrell J; Kandel, Jessica J; Middlesworth, William (2003. ) Anti-VEGF antibody in experimental hepatoblastoma: suppression of tumor growth and altered angiogenesis.Journal of pediatric surgery, , 38 (3 ) ,308-14; discussion 3 More Information

Kim, Eugene S; Serur, Anna; Huang, Jianzhong; Manley, Christina A; McCrudden, Kimberly W; Frischer, Jason S; Soffer, Samuel Z; Ring, Laurence; New, Tamara; Zabski, Stephanie; Rudge, John S; Holash, Jocelyn; Yancopoulos, George D; Kandel, Jessica J; Yamashiro, Darrell J (2002. ) Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma.Proceedings of the National Academy of Sciences of the United States of America, , 99 (17 ) ,11399-404 More Information

Bischoff, Andrea; Frischer, Jason; Knod, Jennifer Leslie; Dickie, Belinda; Levitt, Marc A; Holder, Monica; Jackson, Lyndsey; Peña, Alberto (2017. ) Damaged anal canal as a cause of fecal incontinence after surgical repair for Hirschsprung disease - a preventable and under-reported complication.Journal of pediatric surgery, , 52 (4 ) ,549-553 More Information

Mosiello, Giovanni; Marshall, David; Rolle, Udo; Crétolle, Célia; Santacruz, Bruno G; Frischer, Jason; Benninga, Marc A (2017. ) Consensus Review of Best Practice of Transanal Irrigation in Children.Journal of pediatric gastroenterology and nutrition, , 64 (3 ) ,343-352 More Information

Cushing, Christopher C; Martinez-Leo, Bruno; Bischoff, Andrea; Hall, Jennifer; Helmrath, Michael; Dickie, Belinda H; Levitt, Marc A; Peña, Alberto; Zeller, Meg H; Frischer, Jason S (2016. ) Health-Related Quality of Life and Parental Stress in Children With Fecal Incontinence: A Normative Comparison.Journal of pediatric gastroenterology and nutrition, , 63 (6 ) ,633-636 More Information

Schapiro, Andrew H; Lin, Tom K; Frischer, Jason S; Silverman, Ayaka; Trout, Andrew T (2016. ) Extensive heterotopic gastric mucosa of the small intestine: imaging with (99m)Tc-sodium pertechnetate SPECT/CT enterography.Pediatric radiology, , 46 (13 ) ,1873-1878 More Information

Frischer, Jason S; Rymeski, Beth (2016. ) Complications in colorectal surgery.Seminars in pediatric surgery, , 25 (6 ) ,380-387 More Information

Knod, J Leslie; Holder, Monica; Cortez, Alexander R; Martinez-Leo, Bruno; Kern, Patricia; Saeed, Shehzad; Warner, Brad; Dickie, Belinda; Falcone, Richard A; von Allmen, Daniel; Frischer, Jason S (2016. ) Surgical outcomes, bowel habits and quality of life in young patients after ileoanal anastomosis for ulcerative colitis.Journal of pediatric surgery, , 51 (8 ) ,1246-50 More Information

Martinez-Leo, Bruno; Chesley, Patrick; Alam, Shumyle; Frischer, Jason S; Levitt, Marc A; Avansino, Jeffrey; Dickie, Belinda Hsi (2016. ) The association of the severity of anorectal malformations and intestinal malrotation.Journal of pediatric surgery, , 51 (8 ) ,1241-5 More Information

Knod, J Leslie; Crawford, Kelly; Dusing, Mary; Collins, Margaret H; Chernoguz, Artur; Frischer, Jason S (2016. ) Angiogenesis and Vascular Endothelial Growth Factor-A Expression Associated with Inflammation in Pediatric Crohn's Disease.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, , 20 (3 ) ,624-30 More Information

Knod, Jennifer Leslie; Crawford, Kelly; Dusing, Mary; Frischer, Jason S (2016. ) Murine colitis treated with multitargeted tyrosine kinase inhibitors.The Journal of surgical research, , 200 (2 ) ,501-7 More Information

Yokoi, Akiko; McCrudden, Kimberly W; Huang, Jianzhong; Kim, Eugene S; Soffer, Samuel Z; Frischer, Jason S; Serur, Anna; New, Tamara; Yuan, Jenny; Mansukhani, Mahesh; O'Toole, Kathleen; Yamashiro, Darrell J; Kandel, Jessica J Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor. Oncology reports, , 10 (5 ) ,1271-4

Roayaie, Sasan; Frischer, Jason S; Emre, Sukru H; Fishbein, Thomas M; Sheiner, Patricia A; Sung, Max; Miller, Charles M; Schwartz, Myron E (2002. ) Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters. Annals of surgery, , 235 (4 ) ,533-9

Ahmed H.;Almomani M.;Strine A.C.;Reddy P.P.;Sheldon C.;Frischer J.;Breech L.;Minevich E.;Noh P.H.;VanderBrink B.A. (01-01-2020. ) Clinical urologic and urodynamic outcomes in patients with anorectal malformation and absent vagina .Journal of Pediatric Surgery, , More Information

Nolan H.;Aydin E.;Frischer J.S.;Peiro J.L.;Rymeski B.;Lim F.Y. (10-01-2019. ) Hemorrhage after on-ECMO repair of CDH is equivalent for muscle flap and prosthetic patch.Journal of Pediatric Surgery, , 54 (10 ) ,2044-2047 More Information

Goddard G.;Rymeski B.;Jenkins T.;Mullapudi B.;Dickie B.;Bischoff A.;Peña A.;Levitt M.;Frischer J. (08-01-2019. ) A comparison of surgical complications after appendicostomy and neoappendicostomy in pediatric patie.Journal of Pediatric Surgery, , 54 (8 ) ,1660-1663 More Information

Lobeck I.N.;Bondoc A.;Nolan H.;Frischer J.S.;Campbell K.M.;Ryan T.D.;Goldstein S.L.;Nathan J.D.;Alonso M.H.;Tiao G.M. (11-01-2018. ) Extracorporeal Membrane Oxygenation in a Patient with Biliary Atresia: Case and Review of Extracorpo.ASAIO journal (American Society for Artificial Internal Organs : 1992), , 64 (6 ) ,e191-e195 More Information

Bischoff A.;Brisighelli G.;Dickie B.;Frischer J.;Levitt M.A.;Peña A. (09-01-2018. ) Idiopathic constipation: A challenging but manageable problem.Journal of Pediatric Surgery, , 53 (9 ) ,1742-1747 More Information

Cushing C.C.;Threlkeld M.R.S.;Martinez-Leo B.;Hall J.;Hossain M.;Dickie B.H.;Rymeski B.;Helmrath M.;Zeller M.H.;Frischer J.S. (06-01-2018. ) Initial development and validation of a fecal incontinence-specific quality of life measure.Journal of Pediatric Surgery, , 53 (6 ) ,1148-1153 More Information

Strine A.;VanderBrink B.;Alam Z.;Schulte M.;Noh P.;DeFoor W.;Minevich E.;Sheldon C.;Frischer J.;Reddy P. (08-01-2017. ) Clinical and urodynamic outcomes in children with anorectal malformation subtype of recto-bladder ne.Journal of Pediatric Urology, , 13 (4 ) ,376.e1-376.e6 More Information

Lobeck I.;Frischer J. (01-01-2016. ) Ulcerative colitis and familial polyposis.Fundamentals of Pediatric Surgery, Second Edition, , 545-551 More Information

Knod J.;Bondoc A.;Garrison A.;Bischoff A.;Dickie B.;Frischer J. (11-01-2015. ) Concurrent esophageal atresia with tracheoesophageal fistula and Hirschsprung disease.Journal of Pediatric Surgery Case Reports, , 3 (11 ) ,499-500 More Information

Jurickova I.;Collins M.;Chalk C.;Seese A.;Bezold R.;Lake K.;von Allmen D.;Frischer J.;Falcone R.;Trapnell B.;Denson L. (06-01-2013. ) Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte-macrophage co.Clinical and Experimental Immunology, , 172 (3 ) ,455-465 More Information

Knod L.;Donovan E.;Chernoguz A.;Crawford K.;Dusing M.;Frischer J. (01-01-2013. ) Vascular endothelial growth factor receptor-2 inhibition in experimental murine colitis.Journal of Surgical Research, , 184 (1 ) ,101-107 More Information

Currier M.;Eshun F.;Sholl A.;Chernoguz A.;Crawford K.;Divanovic S.;Boon L.;Goins W.;Frischer J.;Collins M.;Leddon J.;Baird W.;Haseley A.;Streby K.;Wang P.;Hendrickson B.;Brekken R.;Kaur B.;Hildeman D.;Cripe T. (01-01-2013. ) VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells.Molecular Therapy, , 21 (5 ) ,1014-1023 More Information

Frischer J.;Azizkhan R. (12-01-2012. ) Jejunoileal Atresia and Stenosis.Pediatric Surgery, , 1059-1071 More Information

Frischer J.;Stolar C. (12-01-2010. ) Extracorporeal Membrane Oxygenation.Ashcraft's Pediatric Surgery, , 74-86 More Information

Frischer J.;Midulla P.;Dolgin S. (01-01-2002. ) Unexpected benefit of the laparoscopic approach to a complex neonatal ovarian cyst.Pediatric Endosurgery and Innovative Techniques, , 6 (4 ) ,225-228 More Information

Valerie E.;Gilchrist B.F.;Frischer J.;Scriven R.;Klotz D.H.;Ramenofsky M.L. (01-01-1999. ) Diagnosis and treatment of urethral prolapse in children. Urology, , 54 (6 ) ,1082-1084

Contact Information

Academic - Division of Pediatric Surgery
Cincinnati Children's Hospital Medical Center
Cincinnati  Ohio, 45229
Phone: 513-636-8318
jason.frischer@cchmc.org