Jason Frischer

Jason Frischer

Associate Professor of Surgery; Director, Peña Colorectal Center, CCHMC

Childrens Hospital Bldg R

COM Surgery Pediatric - 0054

Division of Pediatric Surgery
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio 45229

Education

Bachelor's Degree, Cornell University 1995 (Nutritional Sciences)

Medical Degree, SUNY Downstate Medical Center 1999

Pediatric Surgery Research/ECMO Fellowship, Columbia University/Children's Hospital of New York 2003 ( )

General Surgery Residency, Mount Sinai School of Medicine 2006

Pediatric Surgery Residency, Columbia University/Children’s Hospital of New York 2008

Research and Practice Interests

Colorectal Surgery, Inflammatory Bowel Disease, Surgical Oncology, Minimally Invasive Surgery, ECMO, Neonatal Surgery

Publications

Peer Reviewed Publications

Fernandez, Emilio; Bischoff, Andrea; Dickie, Belinda H; Frischer, Jason; Hall, Jennifer; Peña, Alberto (2014. )Esophageal atresia in patients with anorectal malformations.Pediatric surgery international, ,30 (8 ),767-71

Bischoff, Andrea; Frischer, Jason; Dickie, Belinda H; Peña, Alberto (2014. )Anorectal malformation without fistula: a defect with unique characteristics.Pediatric surgery international, ,30 (8 ),763-6

Knod, Jennifer Leslie; Crawford, Kelly; Dusing, Mary; Frischer, Jason S (2014. )Mouse strain influences angiogenic response to dextran sodium sulfate-induced colitis.The Journal of surgical research, ,190 (1 ),47-54

Merrow, Arnold C; Frischer, Jason S; Lucky, Anne W (2013. )Pyloric atresia with epidermolysis bullosa: fetal MRI diagnosis with postnatal correlation.Pediatric radiology, ,43 (12 ),1656-61

Eradi, Balgopal; Hamrick, Miller; Bischoff, Andrea; Frischer, Jason S; Helmrath, Michael; Hall, Jennifer; Peña, Alberto; Levitt, Marc A (2013. )The role of a colon resection in combination with a Malone appendicostomy as part of a bowel management program for the treatment of fecal incontinence.Journal of pediatric surgery, ,48 (11 ),2296-300

Landis, Melissa W; Butler, Dawn; Lim, Foong Yen; Keswani, Sundeep; Frischer, Jason; Haberman, Beth; Kingma, Paul S (2013. )Octreotide for chylous effusions in congenital diaphragmatic hernia.Journal of pediatric surgery, ,48 (11 ),2226-9

Knod, Leslie; Donovan, Eileen C; Chernoguz, Artur; Crawford, Kelly M; Dusing, Mary R; Frischer, Jason S (2013. )Vascular endothelial growth factor receptor-2 inhibition in experimental murine colitis.The Journal of surgical research, ,184 (1 ),101-7

Keswani, Sundeep G; Balaji, Swathi; Le, Louis D; Leung, Alice; Parvadia, Jignesh K; Frischer, Jason; Yamano, Seiichi; Taichman, Norton; Crombleholme, Timothy M Role of salivary vascular endothelial growth factor (VEGF) in palatal mucosal wound healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, ,21 (4 ),554-62

Knod, J Leslie; Garrison, Aaron P; Frischer, Jason S; Dickie, Belinda (2013. )Foregut duplication cyst associated with esophageal atresia and tracheoesophageal fistula: a case report and literature review.Journal of pediatric surgery, ,48 (5 ),E5-7

Currier, Mark A; Eshun, Francis K; Sholl, Allyson; Chernoguz, Artur; Crawford, Kelly; Divanovic, Senad; Boon, Louis; Goins, William F; Frischer, Jason S; Collins, Margaret H; Leddon, Jennifer L; Baird, William H; Haseley, Amy; Streby, Keri A; Wang, Pin-Yi; Hendrickson, Brett W; Brekken, Rolf A; Kaur, Balveen; Hildeman, David; Cripe, Timothy P (2013. )VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells.Molecular therapy : the journal of the American Society of Gene Therapy, ,21 (5 ),1014-23

Chernoguz, Artur; Crawford, Kelly; Donovan, Eileen; Vandersall, Abbey; Berglund, Caroline; Cripe, Timothy P; Frischer, Jason S (2012. )EGFR inhibition fails to suppress vascular proliferation and tumor growth in a Ewing's sarcoma model.The Journal of surgical research, ,173 (1 ),1-9

Chernoguz, Artur; Crawford, Kelly; Vandersall, Abbey; Rao, Marepalli; Willson, Tara; Denson, Lee A; Frischer, Jason S (2012. )Pretreatment with anti-VEGF therapy may exacerbate inflammation in experimental acute colitis.Journal of pediatric surgery, ,47 (2 ),347-54

Barnett, Sean J; Frischer, Jason S; Gaskey, John A; Ryckman, Frederick C; von Allmen, Daniel (2012. )Pediatric hernia repair: 1-stop shopping.Journal of pediatric surgery, ,47 (1 ),213-6

Le, Louis D; Keswani, Sundeep G; Biesiada, Jacek; Lim, Foong-Yen; Kingma, Paul S; Haberman, Beth E; Frischer, Jason; Habli, Mounira; Crombleholme, Timothy M (2012. )The congenital diaphragmatic hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic hernia.Journal of pediatric surgery, ,47 (1 ),57-62

Lawal, Taiwo A; Falcone, Richard A; von Allmen, Daniel; Denson, Lee A; Levitt, Marc A; Warner, Brad W; Frischer, Jason S (2011. )The utility of routine pouchogram before ileostomy reversal in children and adolescents following ileal pouch anal anastomosis.Journal of pediatric surgery, ,46 (6 ),1222-5

Lee, Timothy C; Lim, Foong Y; Keswani, Sundeep G; Frischer, Jason S; Haberman, Beth; Kingma, Paul S; Habli, Mounira; Jaekle, Ronald K; Sharp, Gina; Kline-Fath, Beth; Rubio, Eva I; Calvo, Maria; Guimaraes, Carolina; Crombleholme, Timothy M (2011. )Late gestation fetal magnetic resonance imaging-derived total lung volume predicts postnatal survival and need for extracorporeal membrane oxygenation support in isolated congenital diaphragmatic hernia.Journal of pediatric surgery, ,46 (6 ),1165-71

Browne, Andrew W; Leddon, Jennifer L; Currier, Mark A; Williams, Jon P; Frischer, Jason S; Collins, Margaret H; Ahn, Chong H; Cripe, Timothy P (2011. )Cancer screening by systemic administration of a gene delivery vector encoding tumor-selective secretable biomarker expression.PloS one, ,6 (5 ),e19530

Keswani, Sundeep G; Le, Louis D; Morris, Lee M; Lim, Foong-Yen; Katz, Anna B; Ghobril, Nabil; Habli, Mounira; Frischer, Jason S; Crombleholme, Timothy M (2011. )Submucosal gland development in the human fetal trachea xenograft model: implications for fetal gene therapy.Journal of pediatric surgery, ,46 (1 ),33-8

Lawal, Taiwo A; Frischer, Jason S; Falcone, Richard A; Chatoorgoon, Kaveer; Denson, Lee A; Levitt, Marc A (2010. )The transanal approach with laparoscopy or laparotomy for the treatment of rectal strictures in Crohn's disease.Journal of laparoendoscopic & advanced surgical techniques. Part A, ,20 (9 ),791-5

Bischoff, Andrea; Gupta, Anita; D'Mello, Sharon; Mezoff, Adam; Podberesky, Daniel; Barnett, Sean; Keswani, Sundeep; Frischer, Jason S (2010. )Crohn's disease limited to the appendix: a case report in a pediatric patient.Pediatric surgery international, ,26 (11 ),1125-8

Vuletin, Jose F; Lim, Foong-Yen; Cnota, James; Kline-Fath, Beth; Salisbury, Shelia; Haberman, Beth; Kingma, Paul; Frischer, Jason; Crombleholme, Timothy (2010. )Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia.Journal of pediatric surgery, ,45 (4 ),703-8

Dauplaise, Derrick J N; Barnett, Sean J; Frischer, Jason S; Wong, Hector R (2010. )Decompressive abdominal laparotomy for abdominal compartment syndrome in an unengrafted bone marrow recipient with septic shock.Critical care research and practice, ,2010 ,

Ruiz-Elizalde, Alejandro R; Frischer, Jason S; Cowles, Robert A (2009. )Button-loop feeding jejunostomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, ,13 (7 ),1376-8

Ruiz-Elizalde, Alejandro R; Haley, Mary Jo; Fisher, Jason C; Frischer, Jason S; Zitsman, Jeffrey L (2009. )Gastric tube-pericardial fistula: a remote complication of esophageal replacement for long gap esophageal atresia.Journal of pediatric surgery, ,44 (7 ),1440-2

Kadenhe-Chiweshe, Angela; Papa, Joey; McCrudden, Kimberly W; Frischer, Jason; Bae, Jae-O; Huang, Jianzhong; Fisher, Jason; Lefkowitch, Jay H; Feirt, Nikki; Rudge, John; Holash, Jocelyn; Yancopoulos, George D; Kandel, Jessica J; Yamashiro, Darrell J (2008. )Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation.Molecular cancer research : MCR, ,6 (1 ),1-9

Lee, Alice; Frischer, Jason; Serur, Anna; Huang, Jianzhong; Bae, Jae-O; Kornfield, Zev Noah; Eljuga, Lucy; Shawber, Carrie J; Feirt, Nikki; Mansukhani, Mahesh; Stempak, Diana; Baruchel, Sylvain; Glade Bender, Julia; Kandel, Jessica J; Yamashiro, Darrell J (2006. )Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling.Cancer research, ,66 (8 ),4378-84

Bae, Jae-O; Frischer, Jason S; Waich, Margarita; Addonizio, Linda J; Lazar, Eric L; Stolar, Charles J H (2005. )Extracorporeal membrane oxygenation in pediatric cardiac transplantation.Journal of pediatric surgery, ,40 (6 ),1051-6; discussion 1

Frischer, Jason S; Huang, Jianzhong; Serur, Anna; Kadenhe-Chiweshe, Angela; McCrudden, Kimberly W; O'Toole, Kathleen; Holash, Jocelyn; Yancopoulos, George D; Yamashiro, Darrell J; Kandel, Jessica J (2004. )Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature. International journal of oncology, ,25 (3 ),549-53

Frischer, Jason S; Huang, Jianzhong; Serur, Anna; Kadenhe, Angela; Yamashiro, Darrell J; Kandel, Jessica J (2004. )Biomolecular markers and involution of hemangiomas. Journal of pediatric surgery, ,39 (3 ),400-4

Huang, Jianzhong; Frischer, Jason S; New, Tamara; Kim, Eugene S; Serur, Anna; Lee, Alice; Kadenhe-Chiwishe, Angela; Pollyea, Daniel A; Yokoi, Akiko; Holash, Jocelyn; Yancopoulos, George D; Kandel, Jessica J; Yamashiro, Darrell J (2004. )TNP-470 promotes initial vascular sprouting in xenograft tumors. Molecular cancer therapeutics, ,3 (3 ),335-43

Kaicker, Shipra; McCrudden, Kimberly W; Beck, Leal; New, Tamara; Huang, Jianzhong; Frischer, Jason S; Serur, Anna; Kadenhe-Chiweshe, Angela; Yokoi, Akiko; Kandel, Jessica J; Yamashiro, Darrell J (2003. )Thalidomide is anti-angiogenic in a xenograft model of neuroblastoma. International journal of oncology, ,23 (6 ),1651-5

Yokoi, Akiko; McCrudden, Kimberly W; Huang, Jianzhong; Kim, Eugene S; Soffer, Samuel Z; Frischer, Jason S; Serur, Anna; New, Tamara; Yuan, Jenny; Mansukhani, Mahesh; O'toole, Kathleen; Yamashiro, Darrell J; Kandel, Jessica J (2003. )Human epidermal growth factor receptor signaling contributes to tumor growth via angiogenesis in her2/neu-expressing experimental Wilms' tumor. Journal of pediatric surgery, ,38 (11 ),1569-73

Huang, Jianzhong; Frischer, Jason S; Serur, Anna; Kadenhe, Angela; Yokoi, Akiko; McCrudden, Kimberly W; New, Tamara; O'Toole, Kathleen; Zabski, Stephanie; Rudge, John S; Holash, Jocelyn; Yancopoulos, George D; Yamashiro, Darrell J; Kandel, Jessica J (2003. )Regression of established tumors and metastases by potent vascular endothelial growth factor blockade.Proceedings of the National Academy of Sciences of the United States of America, ,100 (13 ),7785-90

McCrudden, Kimberly W; Hopkins, Benjamin; Frischer, Jason; Novikov, Anna; Huang, Jianzhong; Kadenhe, Angela; New, Tamara; Yokoi, Akiko; Yamashiro, Darrell J; Kandel, Jessica J; Middlesworth, William (2003. )Anti-VEGF antibody in experimental hepatoblastoma: suppression of tumor growth and altered angiogenesis.Journal of pediatric surgery, ,38 (3 ),308-14; discussion 3

Kim, Eugene S; Serur, Anna; Huang, Jianzhong; Manley, Christina A; McCrudden, Kimberly W; Frischer, Jason S; Soffer, Samuel Z; Ring, Laurence; New, Tamara; Zabski, Stephanie; Rudge, John S; Holash, Jocelyn; Yancopoulos, George D; Kandel, Jessica J; Yamashiro, Darrell J (2002. )Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma.Proceedings of the National Academy of Sciences of the United States of America, ,99 (17 ),11399-404

Bischoff, Andrea; Frischer, Jason; Knod, Jennifer Leslie; Dickie, Belinda; Levitt, Marc A; Holder, Monica; Jackson, Lyndsey; Peña, Alberto (2017. )Damaged anal canal as a cause of fecal incontinence after surgical repair for Hirschsprung disease - a preventable and under-reported complication.Journal of pediatric surgery, ,52 (4 ),549-553

Mosiello, Giovanni; Marshall, David; Rolle, Udo; Crétolle, Célia; Santacruz, Bruno G; Frischer, Jason; Benninga, Marc A (2017. )Consensus Review of Best Practice of Transanal Irrigation in Children.Journal of pediatric gastroenterology and nutrition, ,64 (3 ),343-352

Cushing, Christopher C; Martinez-Leo, Bruno; Bischoff, Andrea; Hall, Jennifer; Helmrath, Michael; Dickie, Belinda H; Levitt, Marc A; Peña, Alberto; Zeller, Meg H; Frischer, Jason S (2016. )Health-Related Quality of Life and Parental Stress in Children With Fecal Incontinence: A Normative Comparison.Journal of pediatric gastroenterology and nutrition, ,63 (6 ),633-636

Schapiro, Andrew H; Lin, Tom K; Frischer, Jason S; Silverman, Ayaka; Trout, Andrew T (2016. )Extensive heterotopic gastric mucosa of the small intestine: imaging with (99m)Tc-sodium pertechnetate SPECT/CT enterography.Pediatric radiology, ,46 (13 ),1873-1878

Frischer, Jason S; Rymeski, Beth (2016. )Complications in colorectal surgery.Seminars in pediatric surgery, ,25 (6 ),380-387

Knod, J Leslie; Holder, Monica; Cortez, Alexander R; Martinez-Leo, Bruno; Kern, Patricia; Saeed, Shehzad; Warner, Brad; Dickie, Belinda; Falcone, Richard A; von Allmen, Daniel; Frischer, Jason S (2016. )Surgical outcomes, bowel habits and quality of life in young patients after ileoanal anastomosis for ulcerative colitis.Journal of pediatric surgery, ,51 (8 ),1246-50

Martinez-Leo, Bruno; Chesley, Patrick; Alam, Shumyle; Frischer, Jason S; Levitt, Marc A; Avansino, Jeffrey; Dickie, Belinda Hsi (2016. )The association of the severity of anorectal malformations and intestinal malrotation.Journal of pediatric surgery, ,51 (8 ),1241-5

Knod, J Leslie; Crawford, Kelly; Dusing, Mary; Collins, Margaret H; Chernoguz, Artur; Frischer, Jason S (2016. )Angiogenesis and Vascular Endothelial Growth Factor-A Expression Associated with Inflammation in Pediatric Crohn's Disease.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, ,20 (3 ),624-30

Knod, Jennifer Leslie; Crawford, Kelly; Dusing, Mary; Frischer, Jason S (2016. )Murine colitis treated with multitargeted tyrosine kinase inhibitors.The Journal of surgical research, ,200 (2 ),501-7

Yokoi, Akiko; McCrudden, Kimberly W; Huang, Jianzhong; Kim, Eugene S; Soffer, Samuel Z; Frischer, Jason S; Serur, Anna; New, Tamara; Yuan, Jenny; Mansukhani, Mahesh; O'Toole, Kathleen; Yamashiro, Darrell J; Kandel, Jessica J Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor. Oncology reports, ,10 (5 ),1271-4

Roayaie, Sasan; Frischer, Jason S; Emre, Sukru H; Fishbein, Thomas M; Sheiner, Patricia A; Sung, Max; Miller, Charles M; Schwartz, Myron E (2002. )Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters. Annals of surgery, ,235 (4 ),533-9

Ahmed H.;Almomani M.;Strine A.C.;Reddy P.P.;Sheldon C.;Frischer J.;Breech L.;Minevich E.;Noh P.H.;VanderBrink B.A. (01-01-2020. )Clinical urologic and urodynamic outcomes in patients with anorectal malformation and absent vagina .Journal of Pediatric Surgery, ,

Nolan H.;Aydin E.;Frischer J.S.;Peiro J.L.;Rymeski B.;Lim F.Y. (10-01-2019. )Hemorrhage after on-ECMO repair of CDH is equivalent for muscle flap and prosthetic patch.Journal of Pediatric Surgery, ,54 (10 ),2044-2047

Goddard G.;Rymeski B.;Jenkins T.;Mullapudi B.;Dickie B.;Bischoff A.;Peña A.;Levitt M.;Frischer J. (08-01-2019. )A comparison of surgical complications after appendicostomy and neoappendicostomy in pediatric patie.Journal of Pediatric Surgery, ,54 (8 ),1660-1663

Lobeck I.N.;Bondoc A.;Nolan H.;Frischer J.S.;Campbell K.M.;Ryan T.D.;Goldstein S.L.;Nathan J.D.;Alonso M.H.;Tiao G.M. (11-01-2018. )Extracorporeal Membrane Oxygenation in a Patient with Biliary Atresia: Case and Review of Extracorpo.ASAIO journal (American Society for Artificial Internal Organs : 1992), ,64 (6 ),e191-e195

Bischoff A.;Brisighelli G.;Dickie B.;Frischer J.;Levitt M.A.;Peña A. (09-01-2018. )Idiopathic constipation: A challenging but manageable problem.Journal of Pediatric Surgery, ,53 (9 ),1742-1747

Cushing C.C.;Threlkeld M.R.S.;Martinez-Leo B.;Hall J.;Hossain M.;Dickie B.H.;Rymeski B.;Helmrath M.;Zeller M.H.;Frischer J.S. (06-01-2018. )Initial development and validation of a fecal incontinence-specific quality of life measure.Journal of Pediatric Surgery, ,53 (6 ),1148-1153

Strine A.;VanderBrink B.;Alam Z.;Schulte M.;Noh P.;DeFoor W.;Minevich E.;Sheldon C.;Frischer J.;Reddy P. (08-01-2017. )Clinical and urodynamic outcomes in children with anorectal malformation subtype of recto-bladder ne.Journal of Pediatric Urology, ,13 (4 ),376.e1-376.e6

Lobeck I.;Frischer J. (01-01-2016. )Ulcerative colitis and familial polyposis.Fundamentals of Pediatric Surgery, Second Edition, ,545-551

Knod J.;Bondoc A.;Garrison A.;Bischoff A.;Dickie B.;Frischer J. (11-01-2015. )Concurrent esophageal atresia with tracheoesophageal fistula and Hirschsprung disease.Journal of Pediatric Surgery Case Reports, ,3 (11 ),499-500

Jurickova I.;Collins M.;Chalk C.;Seese A.;Bezold R.;Lake K.;von Allmen D.;Frischer J.;Falcone R.;Trapnell B.;Denson L. (06-01-2013. )Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte-macrophage co.Clinical and Experimental Immunology, ,172 (3 ),455-465

Knod L.;Donovan E.;Chernoguz A.;Crawford K.;Dusing M.;Frischer J. (01-01-2013. )Vascular endothelial growth factor receptor-2 inhibition in experimental murine colitis.Journal of Surgical Research, ,184 (1 ),101-107

Currier M.;Eshun F.;Sholl A.;Chernoguz A.;Crawford K.;Divanovic S.;Boon L.;Goins W.;Frischer J.;Collins M.;Leddon J.;Baird W.;Haseley A.;Streby K.;Wang P.;Hendrickson B.;Brekken R.;Kaur B.;Hildeman D.;Cripe T. (01-01-2013. )VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells.Molecular Therapy, ,21 (5 ),1014-1023

Frischer J.;Azizkhan R. (12-01-2012. )Jejunoileal Atresia and Stenosis.Pediatric Surgery, ,1059-1071

Frischer J.;Stolar C. (12-01-2010. )Extracorporeal Membrane Oxygenation.Ashcraft's Pediatric Surgery, ,74-86

Frischer J.;Midulla P.;Dolgin S. (01-01-2002. )Unexpected benefit of the laparoscopic approach to a complex neonatal ovarian cyst.Pediatric Endosurgery and Innovative Techniques, ,6 (4 ),225-228

Valerie E.;Gilchrist B.F.;Frischer J.;Scriven R.;Klotz D.H.;Ramenofsky M.L. (01-01-1999. )Diagnosis and treatment of urethral prolapse in children. Urology, ,54 (6 ),1082-1084

Contact Information

Academic - Division of Pediatric Surgery
Cincinnati Children's Hospital Medical Center
Cincinnati  Ohio, 45229
Phone: 513-636-8318
jason.frischer@cchmc.org