Jason Gardner

Jason C Gardner

Research Assistant Professor

Cardiovascular Rsrch Cntr


COM IM Pulmonary Division - 0564

Professional Summary

My research is focused on understanding the axis of cytokines, signaling pathways and cellular responses that lead to complications in the critically ill. Our current studies are focused on developing interventional strategies that will improve outcomes in patients with bacterial pneumonia or anemia.


Bachelor's Degree: Indiana University Bloomington, IN, 1996 (Microbiology)

Doctoral Degree: University of Cincinnati Cincinnati, OH, 2013 (Pathobiology and Molecular Medicine)

Fellowship: University of Cincinnati Cincinnati, OH, 2016 (Postdoctornal)

Research and Practice Interests

Research Support

Grant: #Billing agreement / T32HL007752 Investigators:Gardner, Jason 07-01-2014 -06-30-2015 National Heart, Lung and Blood Institute T32 Hl7752-21 Jason Gardner Role:PI $52,930.00 Active Level:Federal

Grant: #85104 Investigators:Cancelas-Perez, Jose; Gardner, Jason 01-01-2018 -12-31-2021 Shriners Hospitals for Children - Cincinnati Erythropoietin resistant anemia induced by thermal injury Role:PI $239,500.00 Active Level:Private Non-Profit

Grant: #R01HL155579 Investigators:Gardner, Jason 01-01-2022 -12-31-2026 National Heart, Lung and Blood Institute Inflammatory Mechanisms in Post Burn Anemia of Critical Illness Role:PI 458712.00 Awarded Level:Federal

Grant: #W81XWH-22-1-0849 Investigators:Gardner, Jason; Robson, Matthew 08-01-2022 -07-31-2024 Department of the Army Medical Research Acquisition Activity Targeting IL-1R1 Mediated Anemia in Complex Combat-Related Burns Role:PI 600000.00 Active Level:Federal


Peer Reviewed Publications

Neely, A. N.; Brown, R. L.; Clendening, C. E.; Orloff, M. M.; Gardner, J.; Greenhalgh, D. G. (1997. ) Proteolytic activity in human burn wounds .Wound Repair Regen, , 5 (4 ) ,302-9

Neely, A. N.; Clendening, C. E.; Gardner, J.; Greenhalgh, D. G.; Warden, G. D. (1999. ) Gelatinase activity in keloids and hypertrophic scars .Wound Repair Regen, , 7 (3 ) ,166-71

Neely, A. N.; Clendening, C. E.; Gardner, J.; Greenhalgh, D. G. (2000. ) Gelatinase activities in wounds of healing-impaired mice versus wounds of non-healing-impaired mice .J Burn Care Rehabil, , 21 (5 ) ,395-402

Neely, A. N.; Mayes, T.; Gardner, J.; Kagan, R. J.; Gottschlich, M. M. (2006. ) A microbiologic study of enteral feeding hang time in a burn hospital: can feeding costs be reduced without compromising patient safety? .Nutr Clin Pract, , 21 (6 ) ,610-6

Neely, A. N.; Regnold, L. A.; Hayes, S.; Gardner, J.; Cahill, T. J. (2006. ) Redesign of portable suction equipment cases: an engineering approach to a disinfection problem .Am J Infect Control, , 34 (5 ) ,281-4

Healy, Daniel P.; Gardner, Jason C.; Puthoff, Barbara K.; Kagan, Richard J.; Neely, Alice N. (2007. ) Antibiotic-mediated bacterial filamentation: A potentially important laboratory phenomenon .Clinical Microbiology Newsletter, , 29 (3 ) ,22-24

Smiley, A. K.; Gardner, J.; Klingenberg, J. M.; Neely, A. N.; Supp, D. M. (2007. ) Expression of human beta defensin 4 in genetically modified keratinocytes enhances antimicrobial activity .J Burn Care Res, , 28 (1 ) ,127-32

DiGiandomenico, A.; Rao, J.; Harcher, K.; Zaidi, T. S.; Gardner, J.; Neely, A. N.; Pier, G. B.; Goldberg, J. B. (2007. ) Intranasal immunization with heterologously expressed polysaccharide protects against multiple Pseudomonas aeruginosa infections .Proc Natl Acad Sci U S A, , 104 (11 ) ,4624-9

Supp, D. M.; Gardner, J.; Klingenberg, J. M.; Neely, A. N. (2009. ) Antibiotic resistance in clinical isolates of Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus does not impact sensitivity to human beta defensin 4 .Burns, , 35 (7 ) ,949-55

Neely, A. N.; Gardner, J.; Durkee, P.; Warden, G. D.; Greenhalgh, D. G.; Gallagher, J. J.; Herndon, D. N.; Tompkins, R. G.; Kagan, R. J. (2009. ) Are topical antimicrobials effective against bacteria that are highly resistant to systemic antibiotics? .J Burn Care Res, , 30 (1 ) ,19-29

Tschop, J.; Martignoni, A.; Reid, M. D.; Adediran, S. G.; Gardner, J.; Noel, G. J.; Ogle, C. K.; Neely, A. N.; Caldwell, C. C. (2009. ) Differential immunological phenotypes are exhibited after scald and flame burns .Shock, , 31 (2 ) ,157-63

Osterburg, A.; Gardner, J.; Hyon, S. H.; Neely, A.; Babcock, G. (2009. ) Highly antibiotic-resistant Acinetobacter baumannii clinical isolates are killed by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) .Clin Microbiol Infect, , 15 (4 ) ,341-6

Dugan, A. L.; Gregerson, K. A.; Neely, A.; Gardner, J.; Noel, G. J.; Babcock, G. F.; Horseman, N. D. (2010. ) Mice treated with a benzodiazepine had an improved survival rate following Pseudomonas aeruginosa infection .J Burn Care Res, , 31 (1 ) ,1-12

Healy, D. P.; Sombun, A. D.; Gardner, J. C.; Good, K.; Durkee, P. J.; Toner, L.; Rieman, M. T.; Neely, A. N.; Kagan, R. J. (2011. ) Pharmacokinetics of colistin in an adolescent boy with extensive burn injury .J Burn Care Res, , 32 (1 ) ,e7-11

Gardner, J. C.; Noel, J. G.; Nikolaidis, N. M.; Karns, R.; Aronow, B. J.; Ogle, C. K.; McCormack, F. X. (2014. ) G-CSF drives a posttraumatic immune program that protects the host from infection .J Immunol, , 192 (5 ) ,2405-17

Pasula, R.; Azad, A. K.; Gardner, J. C.; Schlesinger, L. S.; McCormack, F. X. (2015. ) Keratinocyte growth factor administration attenuates murine pulmonary mycobacterium tuberculosis infection through granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent macrophage activation and phagolysosome fusion .J Biol Chem, , 290 (11 ) ,7151-9

Saito, A.; Nikolaidis, N. M.; Amlal, H.; Uehara, Y.; Gardner, J. C.; LaSance, K.; Pitstick, L. B.; Bridges, J. P.; Wikenheiser-Brokamp, K. A.; McGraw, D. W.; Woods, J. C.; Sabbagh, Y.; Schiavi, S. C.; Altinisik, G.; Jakopovic, M.; Inoue, Y.; McCormack, F. X. (2015. ) Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment .Sci Transl Med, , 7 (313 ) ,313ra181

Gardner, J. C.; Wu, H.; Noel, J. G.; Ramser, B. J.; Pitstick, L.; Saito, A.; Nikolaidis, N. M.; McCormack, F. X. (2016. ) Keratinocyte growth factor supports pulmonary innate immune defense through maintenance of alveolar antimicrobial protein levels and macrophage function .Am J Physiol Lung Cell Mol Physiol, , 310 (9 ) ,L868-79

Nikolaidis, Nikolaos M; Noel, John G; Pitstick, Lori B; Gardner, Jason C; Uehara, Yasuaki; Wu, Huixing; Saito, Atsushi; Lewnard, Kara E; Liu, Huan; White, Mitchell R; Hartshorn, Kevan L; McCormack, Francis X (2017. ) Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection.Proceedings of the National Academy of Sciences of the United States of America, , More Information

Noel, John G; Ramser, Benjamin J; Cancelas, Jose A; McCormack, Francis X; Gardner, Jason C (2017. ) Thermal injury of the skin induces G-CSF-dependent attenuation of EPO-mediated STAT signaling and erythroid differentiation arrest in mice.Experimental hematology, , 56 ,16-30 More Information

Noel, John G; Ramser, Seth W; Pitstick, Lori; Goetzman, Holly S; Dale, Elizabeth L; Potter, Andrew; Adam, Mike; Potter, S Steven; Gardner, Jason C (2023. ) IL-1/MyD88-Dependent G-CSF and IL-6 Secretion Mediates Postburn Anemia.Journal of immunology (Baltimore, Md. : 1950), , 210 (7 ) ,972-980 More Information

Uehara, Yasuaki; Tanaka, Yusuke; Zhao, Shuyang; Nikolaidis, Nikolaos M; Pitstick, Lori B; Wu, Huixing; Yu, Jane J; Zhang, Erik; Hasegawa, Yoshihiro; Noel, John G; Gardner, Jason C; Kopras, Elizabeth J; Haffey, Wendy D; Greis, Kenneth D; Guo, Jinbang; Woods, Jason C; Wikenheiser-Brokamp, Kathryn A; Kyle, Jennifer E; Ansong, Charles; Teitelbaum, Steven L; Inoue, Yoshikazu; Altinişik, Göksel; Xu, Yan; McCormack, Francis X (2023. ) Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis.Nature communications, , 14 (1 ) ,1205 More Information

Hasegawa, Yoshihiro; Franks, Jennifer M; Tanaka, Yusuke; Uehara, Yasuaki; Read, David F; Williams, Claire; Srivatsan, Sanjay; Pitstick, Lori B; Nikolaidis, Nikolaos M; Shaver, Ciara M; Wu, Huixing; Gardner, Jason C; Osterburg, Andrew R; Yu, Jane J; Kopras, Elizabeth J; Teitelbaum, Steven L; Wikenheiser-Brokamp, Kathryn A; Trapnell, Cole; McCormack, Francis X (2023. ) Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis.bioRxiv : the preprint server for biology, , More Information

Noel, John G; Ramser, Seth W; Pitstick, Lori; Bonamer, John P; Mackenzie, Bryan; Seu, Katie G; Kalfa, Theodosia A; Cancelas, Jose A; Gardner, Jason C (2022. ) M-CSF supports medullary erythropoiesis and erythroid iron demand following burn injury through its activity on homeostatic iron recycling.Scientific reports, , 12 (1 ) ,1235 More Information

Chowdhury, Debabrata; Gardner, Jason C; Satpati, Abhijit; Nookala, Suba; Mukundan, Santhosh; Porollo, Aleksey; Landero Figueroa, Julio A; Subramanian Vignesh, Kavitha (2021. ) Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity.Frontiers in immunology, , 12 ,755961 More Information

Contact Information

Research - University of Cincinnati
Department of Internal Medicine, Medical Sciences Building
Cincinnati  Ohio, 45267
Phone: 513-558-1717
Fax: 513-558-4858