Education
M.D.: Loyola University of Chicago Stritch School of Medicine Maywood, Illinois, 1992
Ph.D. : The University of Chicago Chicago, Illinois, 1989
B.S.: University of Illinois Chicago, Illinois, 1983 (Chemistry)
Certifications
American Board of Radiology (Radiation Oncology) (Certification Date: 11-03-1997 ) - (Recertification Date: to 01-01-2018 )
Clinical Interests
Lung Cancer
Radiation Oncology
Specialities
Radiation Oncology
Research Support
Grant: #7R01CA257148-06 Investigators:Gius, David -07-15-2027 National Cancer Institute Lineage Plasticity, due to Disruption of MnSOD Biology, drives resistance to Ionizing Radiation / Androgen Deprivation Therapy Role:PI 0.00 Hold Level:Federal
Publications
Peer Reviewed Publications
Maity S.; Venkatesan M.; Chidambaram A.; Uthayabalan S.; Faat Lai L.T.; Clark N.D.; Lakkureddi A.; Ramachandran K.; Bentz K.; Ramalingam R.; Sen S.; Akram M.; Weintraub S.T.; Singh B.B.; Gius D.; Baur J.A.; Theiss A.L.; Caplan J.; Matthies D.; Stathopulos P.B.; Madesh M. (09-22-2026). Prohibitin controls MRS2-Mediated mitochondrial Mg2+ uptake to Shape bioenergetics. Cell Reports, 45 (9) More Information
Khan M.A.; Koniyan S.; Ahir M.; Jegga A.G.; Mayes M.D.; Gius D.; Leung J.; Bonnen M.D.; Montesi S.B.; Ghebre Y.T. (01-01-2026). Esomeprazole inhibits proliferation of scleroderma fibroblasts via cell cycle regulation. Frontiers in Pharmacology, 16More Information
Chocron S.S.; Zhang D.; Sumawi B.; Schell J.; Cruz D.; Li G.; Sreenivas P.; Jiang H.; Dong F.F.; Munkácsy E.; Zhao S.; Porras M.A.G.; Gius D. (01-01-2026). ?3-adrenergic receptor agonist causes acute thermogenic metabolic crisis in ACSS1-K635Q knock-in mic. International Journal of Biological Sciences, 22 (3) , 1070-1081More Information
Leung J.W.; Gius D. (11-17-2025). GSK3? guides chromosomal repair pathway selection to support BRCA1-independent PARP inhibitor sensit. Journal of Clinical Investigation, 135 (22) , 1-3More Information
Wei S.J.; Schell J.; Qian W.; Silguero M.; Baseviciene A.; Chen W.H.; Trevino R.; Chocron E.S.; Ogle M.M.; Varmazyad M.; Martinez G.M.; Cruz D.; Lorenzana B.; Dong F.F.; Jiang H.; Nazarullah A.; Beardsley R.A.; Sharma K.; Chang J.; Munkácsy E.; Horikoshi N.; Gius D. (08-26-2025). Divergent sex-specific effects on a ketogenic diet: Male, but not female, mice exhibit oxidative str. Cell Reports, 44 (8) More Information
Xu G.; Schell J.; Quan S.; Gao Y.; Wei S.J.; Pan M.; Han X.; Li G.; Zhou D.; Jiang H.; Dong F.F.; Munkácsy E.; Horikoshi N.; Gius D. (05-01-2025). Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered liver lipid metabolism on a ketog. Free Radical Biology and Medicine, 232, 260-268More Information
Schell J.R.; Wei S.J.; Zhang J.; Trevino R.; Chen W.H.; Aguilar L.; Qian W.; Corbett C.W.; Jiang H.; Dong F.F.; Chocron E.S.; Nazarullah A.; Chang J.; Flanagan M.E.; Glatt V.; Dikalov S.; Munkácsy E.; Horikoshi N.; Gius D. (03-01-2025). MnSOD non-acetylation mimic knock-in mice exhibit dilated cardiomyopathy. Free Radical Biology and Medicine, 229, 58-67More Information
Xu G.; Quan S.; Schell J.; Gao Y.; Varmazyad M.; Sreenivas P.; Cruz D.; Jiang H.; Pan M.; Han X.; Palavicini J.P.; Zhao P.; Sun X.; Marchant E.D.; Rasmussen B.B.; Li G.; Katsumura S.; Morita M.; Munkácsy E.; Horikoshi N.; Sandra Chocron E.; Gius D. (05-17-2024). Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and . Science Advances, 10 (20) More Information
Wei S.J.; Schell J.R.; Chocron E.S.; Varmazyad M.; Xu G.; Chen W.H.; Martinez G.M.; Dong F.F.; Sreenivas P.; Trevino R.; Jiang H.; Du Y.; Saliba A.; Qian W.; Lorenzana B.; Nazarullah A.; Chang J.; Sharma K.; Munkácsy E.; Horikoshi N.; Gius D. (05-17-2024). Ketogenic diet induces p53-dependent cellular senescence in multiple organs. Science Advances, 10 (20) More Information
Ogle M.M.; Trevino R.; Schell J.; Varmazyad M.; Horikoshi N.; Gius D. (04-01-2022). Manganese Superoxide Dismutase Acetylation and Regulation of Protein Structure in Breast Cancer Biol. Antioxidants, 11 (4) More Information
Prasanna P.G.; Citrin D.E.; Hildesheim J.; Ahmed M.M.; Venkatachalam S.; Riscuta G.; Xi D.; Zheng G.; Deursen J.v.; Goronzy J.; Kron S.J.; Anscher M.S.; Sharpless N.E.; Campisi J.; Brown S.L.; Niedernhofer L.J.; O'loghlen A.; Georgakilas A.G.; Paris F.; Gius D.; Gewirtz D.A.; Schmitt C.A.; Abazeed M.E.; Kirkland J.L.; Richmond A.; Romesser P.B.; Lowe S.W.; Gil J.; Mendonca M.S.; Burma S.; Zhou D.; Coleman C.N. (10-01-2021). Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy. Journal of the National Cancer Institute, 113 (10) , 1285-1298More Information
Cheresh P.; Kim S.J.; Jablonski R.; Watanabe S.; Lu Z.; Chi M.; Helmin K.A.; Gius D.; Scott Budinger G.R.; Kamp D.W. (07-01-2021). SIRT3 overexpression ameliorates asbestos-induced pulmonary fibrosis, mt-DNA damage and lung fibroge. International Journal of Molecular Sciences, 22 (13) More Information
Gao Y.; Zhu Y.; Tran E.L.; Tokars V.; Dean A.E.; Quan S.; Gius D. (01-01-2021). Mnsod lysine 68 acetylation leads to cisplatin and doxorubicin resistance due to aberrant mitochondr. International Journal of Biological Sciences, 17 (5) , 1203-1216More Information
Vidimar V.; Beilhartz G.L.; Park M.; Biancucci M.; Kieffer M.B.; Gius D.R.; Melnyk R.A.; Satchell K.J.F. (07-21-2020). An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth. Proceedings of the National Academy of Sciences of the United States of America, 117 (29) , 16938-16948More Information
Zhou Z.; Song X.; Chi J.(.; Gius D.R.; Huang Y.; Cristofanilli M.; Wan Y. (06-01-2020). Regulation of KLF4 by posttranslational modification circuitry in endocrine resistance. Cellular Signalling, 70More Information
Zhu Y.; Zou X.; Dean A.E.; Brien J.O.; Gao Y.; Tran E.L.; Park S.H.; Liu G.; Kieffer M.B.; Jiang H.; Stauffer M.E.; Hart R.; Quan S.; Satchell K.J.F.; Horikoshi N.; Bonini M.; Gius D. (12-01-2019). Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor . Nature Communications, 10 (1) More Information
Zhang S.; Weinberg S.; DeBerge M.; Gainullina A.; Schipma M.; Kinchen J.M.; Ben-Sahra I.; Gius D.R.; Yvan-Charvet L.; Chandel N.S.; Schumacker P.T.; Thorp E.B. (02-05-2019). Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polariz. Cell Metabolism, 29 (2) , 443-456.e5More Information
Kosciuczuk E.M.; Mehrotra S.; Saleiro D.; Kroczynska B.; Majchrzak-Kita B.; Lisowski P.; Driehaus C.; Rogalska A.; Turner A.; Lienhoop T.; Gius D.; Fish E.N.; Vassilopoulos A.; Platanias L.C. (01-18-2019). Sirtuin 2–mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I int. Journal of Biological Chemistry, 294 (3) , 827-837More Information
Gius D.; Zhu Y. (01-01-2019). Homeostatic roles of STING in cell proliferation and chromosomal instability. Cancer Research, 79 (7) , 1295-1296More Information
He C.; Danes J.M.; Hart P.C.; Zhu Y.; Huang Y.; de Abreu A.L.; O’Brien J.; Mathison A.J.; Tang B.; Frasor J.M.; Wakefield L.M.; Ganini D.; Stauder E.; Zielonka J.; Gantner B.N.; Urrutia R.A.; Gius D.; Bonini M.G. (01-01-2019). SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 116 (47) , 23534-23541More Information
Quan S.; Principe D.R.; Dean A.E.; Park S.H.; Grippo P.J.; Gius D.; Horikoshi N. (12-01-2018). Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induc. Scientific Reports, 8 (1) More Information
Lantier L.; Williams A.S.; Hughey C.C.; Bracy D.P.; James F.D.; Ansari M.A.; Gius D.; Wasserman D.H. (12-01-2018). SIRT2 knockout exacerbates insulin resistance in high fat-fed mice. Plos One, 13 (12) More Information
Kibria G.; Ramos E.K.; Wan Y.; Gius D.R.; Liu H. (09-04-2018). Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges. Molecular Pharmaceutics, 15 (9) , 3625-3633More Information
Zhu Y.; Dean A.E.; Horikoshi N.; Heer C.; Spitz D.R.; Gius D. (08-31-2018). Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy. Journal of Clinical Investigation, 128 (9) , 3682-3691More Information
Vassilopoulos A.; Wang R.H.; Gius D. (04-25-2018). Mammalian Sirtuins, Cellular Energy Regulation, and Metabolism, and Carcinogenesis. Introductory Review on Sirtuins in Biology Aging and Disease, 141-154More Information
Zhu Y.; Gius D. (04-01-2018). Glycogen phosphorylase: A novel biomarker in doxorubicin-induced cardiac injury. Clinical Cancer Research, 24 (7) , 1516-1517More Information
Song H.Y.; Rellinger E.J.; Park S.H.; Paul P.; Qiao J.; Vasilopoulos A.; Ozden O.; Gius D.; Chung D.H. (02-01-2018). Inhibition of sirtuin 6 induces neuroblastoma differentiation. Anticancer Research, 38 (2) , 647-654More Information
Traver G.; Mont S.; Gius D.; Lawson W.E.; Ding G.X.; Sekhar K.R.; Freeman M.L. (11-01-2017). Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung. Free Radical Biology and Medicine, 112, 578-586More Information
Zou X.; Ratti B.A.; O’Brien J.G.; Lautenschlager S.O.; Gius D.R.; Bonini M.G.; Zhu Y. (08-01-2017). Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox sign. Journal of Bioenergetics and Biomembranes, 49 (4) , 325-333More Information
Zou X.; Zhu Y.; Park S.H.; Liu G.; O'Brien J.; Jiang H.; Gius D. (08-01-2017). SIRT3-mediated dimerization of IDH2 directs cancer cell metabolism and tumor growth. Cancer Research, 77 (15) , 3990-3999More Information
Traba J.; Geiger S.S.; Kwarteng-Siaw M.; Han K.; Ra O.H.; Siegel R.M.; Gius D.; Sack M.N. (07-21-2017). Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-medi. Journal of Biological Chemistry, 292 (29) , 12153-12164More Information
Jablonski R.P.; Kim S.J.; Cheresh P.; Williams D.B.; Morales-Nebreda L.; Cheng Y.; Yeldandi A.; Bhorade S.; Pardo A.; Selman M.; Ridge K.; Gius D.; Budinger G.R.S.; Kamp D.W. (06-01-2017). SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA dam. FASEB Journal, 31 (6) , 2520-2532More Information
Liu G.; Park S.H.; Imbesi M.; Nathan W.J.; Zou X.; Zhu Y.; Jiang H.; Parisiadou L.; Gius D. (05-20-2017). Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dys. Antioxidants and Redox Signaling, 26 (15) , 846-863More Information
Shi H.; Deng H.X.; Gius D.; Schumacker P.T.; Surmeier D.J.; Ma Y.C. (05-15-2017). Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress. Human Molecular Genetics, 26 (10) , 1915-1926More Information
Yang X.; Park S.H.; Chang H.C.; Shapiro J.S.; Vassilopoulos A.; Sawicki K.T.; Chen C.; Shang M.; Burridge P.W.; Epting C.L.; Wilsbacher L.D.; Jenkitkasemwong S.; Knutson M.; Gius D.; Ardehali H. (04-03-2017). Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2. Journal of Clinical Investigation, 127 (4) , 1505-1516More Information
Vidimar V.; Gius D.; Chakravarti D.; Bulun S.E.; Wei J.J.; Kim J.J. (11-01-2016). Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uter. Science Advances, 2 (11) More Information
Zou X.; Santa-Maria C.A.; O'Brien J.; Gius D.; Zhu Y. (08-20-2016). Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote. Antioxidants and Redox Signaling, 25 (6) , 326-336More Information
Park S.H.; Ozden O.; Liu G.; Song H.Y.; Zhu Y.; Yan Y.; Zou X.; Kang H.J.; Jiang H.; Principe D.R.; Cha Y.I.; Roh M.; Vassilopoulos A.; Gius D. (07-01-2016). SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor gro. Cancer Research, 76 (13) , 3802-3812More Information
Wang X.X.; Edelstein M.H.; Gafter U.; Qiu L.; Luo Y.; Dobrinskikh E.; Lucia S.; Adorini L.; D'Agati V.D.; Levi J.; Rosenberg A.; Kopp J.B.; Gius D.R.; Saleem M.A.; Levi M. (05-01-2016). G protein-coupled bile acid receptor TGR5 activation inhibits kidney disease in obesity and diabetes. Journal of the American Society of Nephrology, 27 (5) , 1362-1378More Information
Zhang H.; Head P.S.E.; Daddacha W.; Park S.H.; Li X.; Pan Y.; Madden M.Z.; Duong D.M.; Xie M.; Yu B.; Warren M.D.; Liu E.A.; Dhere V.R.; Li C.; Pradilla I.; Torres M.A.; Wang Y.; Dynan W.S.; Doetsch P.W.; Deng X.; Seyfried N.T.; Gius D.; Yu D.S. (02-16-2016). ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA. Cell Reports, 14 (6) , 1435-1447More Information
Song H.Y.; Biancucci M.; Kang H.J.; O'Callaghan C.; Park S.H.; Principe D.R.; Jiang H.; Yan Y.; Satchell K.F.; Raparia K.; Gius D.; Vassilopoulos A. (01-01-2016). SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status. Oncotarget, 7 (49) , 80336-80349More Information
Zhu Y.; Paul P.; Lee S.; Craig B.T.; Rellinger E.J.; Qiao J.; Gius D.R.; Chung D.H. (09-01-2015). Antioxidant inhibition of steady-state reactive oxygen species and cell growth in neuroblastoma. Surgery United States, 158 (3) , 827-836More Information
Lantier L.; Williams A.S.; Williams I.M.; Yang K.K.; Bracy D.P.; Goelzer M.; James F.D.; Gius D.; Wasserman D.H. (09-01-2015). SIRT3 is crucial for maintaining skeletal muscle insulin action and protects against severe insulin . Diabetes, 64 (9) , 3081-3092More Information
Liu R.; Fan M.; Candas D.; Qin L.; Zhang X.; Eldridge A.; Zou J.X.; Zhang T.; Juma S.; Jin C.; Li R.F.; Perks J.; Sun L.Q.; Vaughan A.T.M.; Hai C.X.; Gius D.R.; Li J.J. (09-01-2015). CDK1-mediated SIRT3 activation enhances mitochondrial function and tumor radioresistance. Molecular Cancer Therapeutics, 14 (9) , 2090-2102More Information
Antic I.; Biancucci M.; Zhu Y.; Gius D.R.; Satchell K.J.F. (06-08-2015). Site-specific processing of Ras and Rap1 Switch i by a MARTX toxin effector domain. Nature Communications, 6More Information
Vassilopoulos A.; Tominaga Y.; Kim H.S.; Lahusen T.; Li B.; Yu H.; Gius D.; Deng C.X. (06-04-2015). WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carc. Oncogene, 34 (23) , 3023-3035More Information
Pillai V.B.; Samant S.; Sundaresan N.R.; Raghuraman H.; Kim G.; Bonner M.Y.; Arbiser J.L.; Walker D.I.; Jones D.P.; Gius D.; Gupta M.P. (04-14-2015). Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3. Nature Communications, 6More Information
Agarwal S.; Zhu Y.; Gius D.R.; Satchell K.J.F. (01-01-2015). The Makes Caterpillars Floppy (MCF)-like domain of Vibrio vulnificus induces mitochondrion-mediated . Infection and Immunity, 83 (11) , 4392-4403More Information
Tao R.; Leclerc J.; Yildiz K.; Park S.H.; Jung B.; Gius D.; Özden Ö. (01-01-2015). Changes in gene expression in SIRT3 knockout liver cells. Turkish Journal of Biology, 39 (3) , 380-387More Information
Vassilopoulos A.; Pennington J.D.; Andresson T.; Rees D.M.; Bosley A.D.; Fearnley I.M.; Ham A.; Flynn C.R.; Hill S.; Rose K.L.; Kim H.S.; Deng C.X.; Walker J.E.; Gius D. (08-01-2014). SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient-and exercise-induced str. Antioxidants and Redox Signaling, 21 (4) , 551-564More Information
Xu Y.; Gao X.D.; Lee J.H.; Huang H.; Tan H.; Ahn J.; Reinke L.M.; Peter M.E.; Feng Y.; Gius D.; Siziopikou K.P.; Peng J.; Xiao X.; Cheng C. (06-01-2014). Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative. Genes and Development, 28 (11) , 1191-1203More Information
Tao R.; Vassilopoulos A.; Parisiadou L.; Yan Y.; Gius D. (04-01-2014). Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling netwo. Antioxidants and Redox Signaling, 20 (10) , 1646-1654More Information
Coleman M.C.; Olivier A.K.; Jacobus J.A.; Mapuskar K.A.; Mao G.; Martin S.M.; Riley D.P.; Gius D.; Spitz D.R. (03-20-2014). Superoxide mediates acute liver injury in irradiated mice lacking Sirtuin 3. Antioxidants and Redox Signaling, 20 (9) , 1423-1435More Information
Nottingham L.K.; Yan C.H.; Yang X.; Si H.; Coupar J.; Bian Y.; Cheng T.F.; Allen C.; Arun P.; Gius D.; Dang L.; Van Waes C.; Chen Z. (02-27-2014). Aberrant IKK? and IKK? cooperatively activate NF-?B and induce EGFR/AP1 signaling to promote surviva. Oncogene, 33 (9) , 1135-1147More Information
Desouki M.M.; Doubinskaia I.; Gius D.; Abdulkadir S.A. (01-01-2014). Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor out. Human Pathology, 45 (5) , 1071-1077More Information
Ozden O.; Park S.H.; Wagner B.A.; Song H.Y.; Zhu Y.; Vassilopoulos A.; Jung B.; Buettner G.R.; Gius D. (01-01-2014). SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells. Free Radical Biology and Medicine, 76, 163-172More Information
Chi A.; Nguyen N.P.; Welsh J.S.; Tse W.; Monga M.; Oduntan O.; Almubarak M.; Rogers J.; Remick S.C.; Gius D. (01-01-2014). Strategies of dose escalation in the treatment of locally advanced non-small cell lung cancer: Image. Frontiers in Oncology, 4 JUNMore Information
Zhu Y.; Yan Y.; Gius D.; Vassilopoulos A. (11-01-2013). Metabolic regulation of Sirtuins upon fasting and the implication for cancer. Current Opinion in Oncology, 25 (6) , 630-636More Information
Horn L.; Eisenberg R.; Gius D.; Kimmelshue K.; Massion P.; Putnam J.; Robinson C.; Carbone D. (10-22-2013). Cancer of the Lung: Non-Small Cell Lung Cancer and Small Cell Lung Cancer. Abeloff S Clinical Oncology Fifth Edition, 1143-1192More Information
Liang Q.; Benavides G.A.; Vassilopoulos A.; Gius D.; Darley-Usmar V.; Zhang J. (09-01-2013). Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic . Biochemical Journal, 454 (2) , 249-257More Information
Zhang H.; Park S.H.; Pantazides B.G.; Karpiuk O.; Warren M.D.; Hardy C.W.; Duong D.M.; Park S.J.; Kim H.S.; Vassilopoulos A.; Seyfried N.T.; Johnsen S.A.; Gius D.; Yu D.S. (08-13-2013). SIRT2 directs the replication stress response through CDK9 deacetylation. Proceedings of the National Academy of Sciences of the United States of America, 110 (33) , 13546-13551More Information
Jacobus J.A.; Duda C.G.; Coleman M.C.; Martin S.M.; Mapuskar K.; Mao G.; Smith B.J.; Aykin-Burns N.; Guida P.; Gius D.; Domann F.E.; Knudson C.M.; Spitz D.R. (08-01-2013). Low-dose radiation-induced enhancement of thymic lymphomagenesis in lck-bax mice is dependent on LET. Radiation Research, 180 (2) , 156-165More Information
Shankavaram U.; Fliedner S.; Elkahloun A.; Barb J.; Munson P.; Huynh T.; Matro J.; Turkova H.; Marston Linehan W.; Timmers H.; Tischler A.; Powers J.; de Krijger R.; Baysal B.; Takacova M.; Pastorekova S.; Gius D.; Lehnert H.; Camphausen K.; Pacak K. (01-01-2013). Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragan. Neoplasia United States, 15 (4) , 435-447More Information
Peek C.B.; Affinati A.H.; Ramsey K.M.; Kuo H.Y.; Yu W.; Sena L.A.; Ilkayeva O.; Marcheva B.; Kobayashi Y.; Omura C.; Levine D.C.; Bacsik D.J.; Gius D.; Newgard C.B.; Goetzman E.; Chandel N.S.; Denu J.M.; Mrksich M.; Bass J. (01-01-2013). Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science, 342 (6158) More Information
Zhu Y.; Park S.H.; Ozden O.; Kim H.S.; Jiang H.; Vassilopoulos A.; Spitz D.R.; Gius D. (08-15-2012). Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation stat. Free Radical Biology and Medicine, 53 (4) , 828-833More Information
Park S.H.; Zhu Y.; Ozden O.; Kim H.S.; Jiang H.; Deng C.X.; Gius D.; Vassilopoulos A. (06-01-2012). SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis. Translational Cancer Research, 1 (1) , 15-21More Information
Haigis M.C.; Deng C.X.; Finley L.W.S.; Kim H.S.; Gius D. (05-15-2012). SIRT3 is a mitochondrial tumor suppressor: A scientific tale that connects aberrant cellular ROS, th. Cancer Research, 72 (10) , 2468-2472More Information
Wang J.; Anderson P.D.; Luo W.; Gius D.; Roh M.; Abdulkadir S.A. (04-05-2012). Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells. Oncogene, 31 (14) , 1794-1803More Information
Scarbrough P.M.; Mapuskar K.A.; Mattson D.M.; Gius D.; Watson W.H.; Spitz D.R. (01-15-2012). Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potenti. Free Radical Biology and Medicine, 52 (2) , 436-443More Information
Spitz D.R.; Dornfeld K.J.; Krishnan K.; Gius D. (01-01-2012). Oxidative stress in cancer biology and therapy. Oxidative Stress in Cancer Biology and Therapy, 1-460More Information
Park S.H.; Ozden O.; Jiang H.; Cha Y.I.; Pennington J.D.; Aykin-Burns N.; Spitz D.R.; Gius D.; Kim H.S. (09-01-2011). Sirt3, mitochondrial ROS, ageing, and carcinogenesis. International Journal of Molecular Sciences, 12 (9) , 6226-6239More Information
Kendrick A.A.; Choudhury M.; Rahman S.M.; McCurdy C.E.; Friederich M.; Van Hove J.L.K.; Watson P.A.; Birdsey N.; Bao J.; Gius D.; Sack M.N.; Jing E.; Kahn C.R.; Friedman J.E.; Jonscher K.R. (02-01-2011). Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. Biochemical Journal, 433 (3) , 505-514More Information
Vassilopoulos A.; Fritz K.S.; Petersen D.R.; Gius D. (01-01-2011). The human sirtuin family: Evolutionary divergences and functions. Human Genomics, 5 (5) , 485-496More Information
Kamrava M.; Gius D.; Casagrande G.; Kohn E. (01-01-2011). Will targeting insulin growth factor help us or hurt us?: An oncologist's perspective. Ageing Research Reviews, 10 (1) , 62-70More Information
Ozden O.; Park S.H.; Kim H.S.; Jiang H.; Coleman M.C.; Spitz D.R.; Gius D. (01-01-2011). Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative . Aging, 3 (2) , 102-107More Information
Kim H.S.; Vassilopoulos A.; Wang R.H.; Lahusen T.; Xiao Z.; Xu X.; Li C.; Veenstra T.D.; Li B.; Yu H.; Ji J.; Wang X.W.; Park S.H.; Cha Y.I.; Gius D.; Deng C.X. (01-01-2011). SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity. Cancer Cell, 20 (4) , 487-499More Information
Tao R.; Coleman M.C.; Pennington J.D.; Ozden O.; Park S.H.; Jiang H.; Kim H.S.; Flynn C.R.; Hill S.; McDonald W.H.; Olivier A.K.; Spitz D.R.; Gius D. (12-22-2010). Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Resp. Molecular Cell, 40 (6) , 893-904More Information
Xiao C.; Kim H.S.; Lahusen T.; Wang R.H.; Xu X.; Gavrilova O.; Jou W.; Gius D.; Deng C.X. (11-19-2010). SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated gluco. Journal of Biological Chemistry, 285 (47) , 36776-36784More Information
Bao J.; Scott I.; Lu Z.; Pang L.; Dimond C.; Gius D.; Sack M. (10-01-2010). SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity. Free Radical Biology and Medicine, 49 (7) , 1230-1237More Information
Baur J.A.; Chen D.; Chini E.N.; Chua K.; Cohen H.Y.; De Cabo R.; Deng C.; Dimmeler S.; Gius D.; Guarente L.P.; Helfand S.L.; Imai S.I.; Itoh H.; Kadowaki T.; Koya D.; Leeuwenburgh C.; Mcburney M.; Nabeshima Y.O.I.; Neri C.; Oberdoerffer P.; Pestell R.G.; Rogina B.; Sadoshima J.; Sartorelli V.; Serrano M.; Sinclair D.A.; Steegborn C.; Tatar M.; Tissenbaum H.A.; Tong Q.; Tsubota K.; Vaquero A.; Verdin E. (08-27-2010). Dietary restriction: Standing up for sirtuins. Science, 329 (5995) , 1012-1013More Information
Van Waes C.; Allen C.T.; Citrin D.; Gius D.; Colevas A.D.; Harold N.A.; Rudy S.; Nottingham L.; Muir C.; Chen Z.; Singh A.K.; Dancey J.; Morris J.C. (06-01-2010). Molecular and Clinical Responses in a Pilot Study of Gefitinib With Paclitaxel and Radiation in Loca. International Journal of Radiation Oncology Biology Physics, 77 (2) , 447-454More Information
Bao J.; Lu Z.; Joseph J.J.; Carabenciov D.; Dimond C.C.; Pang L.; Samsel L.; McCoy J.P.; Leclerc J.; Nguyen P.M.; Gius D.; Sack M.N. (05-01-2010). Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochond. Journal of Cellular Biochemistry, 110 (1) , 238-247More Information
Kim H.S.; Patel K.; Muldoon-Jacobs K.; Bisht K.S.; Aykin-Burns N.; Pennington J.D.; van der Meer R.; Nguyen P.; Savage J.; Owens K.M.; Vassilopoulos A.; Ozden O.; Park S.H.; Singh K.K.; Abdulkadir S.A.; Spitz D.R.; Deng C.X.; Gius D. (01-19-2010). SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integri. Cancer Cell, 17 (1) , 41-52More Information
Kassis J.N.; Virador V.M.; Guancial E.A.; Kimm D.; Ho A.S.; Mishra M.; Chuang E.Y.; Cook J.; Gius D.; Kohn E.C. (08-01-2009). Genomic and phenotypic analysis reveals a key role for CCN1 (CYR61) in BAG3 - Modulated adhesion and. Journal of Pathology, 218 (4) , 495-504More Information
Simone N.L.; Soule B.P.; Ly D.; Saleh A.D.; Savage J.E.; DeGraff W.; Cook J.; Harris C.C.; Gius D.; Mitchell J.B. (07-27-2009). Ionizing radiation-induced oxidative stress alters miRNA expression. Plos One, 4 (7) More Information
Sharp H.; Morris J.C.; Van Waes C.; Gius D.; Cooley-Zgela T.; Singh A.K. (12-01-2008). High incidence of oral dysesthesias on a trial of gefitinib, paclitaxel, and concurrent external bea. American Journal of Clinical Oncology Cancer Clinical Trials, 31 (6) , 557-560More Information
Rader J.S.; Malone J.P.; Gross J.; Gilmore P.; Brooks R.A.; Nguyen L.; Crimmins D.L.; Feng S.; Wright J.D.; Taylor N.; Zighelboim I.; Funk M.C.; Huettner P.C.; Ledenson J.H.; Gius D.; Townsend R.R. (12-01-2008). A unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to ident. Proteomics Clinical Applications, 2 (12) , 1658-1669More Information
Nguyen P.; Bar-Sela G.; Sun L.; Bisht K.S.; Cui H.; Kohn E.; Feinberg A.P.; Gius D. (11-01-2008). BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expre. Molecular and Cellular Biology, 28 (21) , 6720-6729More Information
Jacobs K.M.; Pennington J.D.; Bisht K.S.; Aykin-Burns N.; Kim H.S.; Mishra M.; Sun L.; Nguyen P.; Ahn B.H.; Leclerc J.; Deng C.X.; Spitz D.R.; Gius D. (09-05-2008). SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a depe. International Journal of Biological Sciences, 4 (5) , 291-299More Information
Trimble E.L.; Harlan L.C.; Gius D.; Stevens J.; Schwartz S.M. (08-15-2008). Patterns of care for women with cervical cancer in the United States. Cancer, 113 (4) , 743-749More Information
Nguyen P.; Cui H.; Bisht K.S.; Sun L.; Patel K.; Lee R.S.; Kugoh H.; Oshimura M.; Feinberg A.P.; Gius D. (07-15-2008). CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the patern. Cancer Research, 68 (14) , 5546-5551More Information
Sun L.; Huang L.; Nguyen P.; Bisht K.S.; Bar-Sela G.; Ho A.S.; Bradbury C.M.; Yu W.; Cui H.; Lee S.; Trepel J.B.; Feinberg A.P.; Gius D. (04-15-2008). DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulati. Cancer Research, 68 (8) , 2726-2735More Information
Mishra M.V.; Bisht K.S.; Sun L.; Muldoon-Jacobs K.; Awwad R.; Kaushal A.; Nguyen P.; Huang L.; Pennington J.D.; Markovina S.; Bradbury C.M.; Gius D. (02-01-2008). DNMT1 as a molecular target in a multimodality-resistant phenotype in tumor cells. Molecular Cancer Research, 6 (2) , 243-249More Information
Yu W.; Gius D.; Onyango P.; Muldoon-Jacobs K.; Karp J.; Feinberg A.P.; Cui H. (01-01-2008). Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature, 451 (7175) , 202-206More Information
Guo Z.; Tsai M.H.; Shiao Y.H.; Chen L.H.; Wei M.L.; Lv X.; Gius D.; Little J.B.; Mitchell J.B.; Chuang E.Y. (01-01-2008). DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16ink4A down-regulation. Journal of Biomedical Science, 15 (2) , 163-168More Information
Annunziata C.; Kleinberg L.; Davidson B.; Berner A.; Gius D.; Tchabo N.; Steinberg S.; Kohn E. (11-15-2007). BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian . Clinical Cancer Research, 13 (22) , 6585-6592More Information
Gius D.; Funk M.C.; Chuang E.Y.; Feng S.; Huettner P.C.; Nguyen L.; Bradbury C.M.; Mishra M.; Gao S.; Buttin B.M.; Cohn D.E.; Powell M.A.; Horowitz N.S.; Whitcomb B.P.; Rader J. (08-01-2007). Profiling microdissected epithelium and stroma to model genomic signatures for cervical carcinogenes. Cancer Research, 67 (15) , 7113-7123More Information
Bar-Sela G.; Jacobs K.M.; Gius D. (01-01-2007). Histone deacetylase inhibitor and demethylating agent chromatin compaction and the radiation respons. Cancer Journal, 13 (1) , 65-69More Information
Pennington J.D.; Jacobs K.M.; Sun L.; Bar-Sela G.; Mishra M.; Gius D. (01-01-2007). Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy. Current Pharmaceutical Design, 13 (33) , 3368-3377More Information
Fitzpatrick M.A.; Funk M.C.; Gius D.; Huettner P.C.; Zhang Z.; Bidder M.; Ma D.; Powell M.A.; Rader J.S. (11-01-2006). Identification of chromosomal alterations important in the development of cervical intraepithelial n. Gynecologic Oncology, 103 (2) , 458-462More Information
Gius D.; Spitz D.R. (07-01-2006). Redox signaling in cancer biology. Antioxidants and Redox Signaling, 8 (7-8) , 1249-1252More Information
Zhao W.; Chuang E.Y.; Mishra M.; Awwad R.; Bisht K.; Sun L.; Nguyen P.; Pennington J.D.; Wang T.J.C.; Bradbury C.M.; Huang L.; Chen Z.; Bar-Sela G.; Robbins M.E.C.; Gius D. (06-15-2006). Distinct effects of ionizing radiation on in vivo murine kidney and brain normal tissue gene express. Clinical Cancer Research, 12 (12) , 3823-3830More Information
Nguyen P.; Awwad R.T.; Smart D.D.K.; Spitz D.R.; Gius D. (05-18-2006). Thioredoxin reductase as a novel molecular target for cancer therapy. Cancer Letters, 236 (2) , 164-174More Information
Barker C.; Burgan W.; Carter D.; Cerna D.; Gius D.; Hollingshead M.; Camphausen K.; Tofilon P. (05-01-2006). In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor triapine (. Clinical Cancer Research, 12 (9) , 2912-2918More Information
Van Waes C.; Chang A.A.; Lebowitz P.F.; Druzgal C.H.; Chen Z.; Elsayed Y.A.; Sunwoo J.B.; Rudy S.F.; Morris J.C.; Mitchell J.B.; Camphausen K.; Gius D.; Adams J.; Sausville E.A.; Conley B.A. (12-01-2005). Inhibition of nuclear factor-?B and target genes during combined therapy with proteasome inhibitor b. International Journal of Radiation Oncology Biology Physics, 63 (5) , 1400-1412More Information
Stoyanovsky D.A.; Tyurina Y.Y.; Tyurin V.A.; Anand D.; Mandavia D.N.; Gius D.; Ivanova J.; Pitt B.; Billiar T.R.; Kagan V.E. (11-16-2005). Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitroso. Journal of the American Chemical Society, 127 (45) , 15815-15823More Information
Gius D.; Bradbury C.M.; Sun L.; Awwad R.T.; Huang L.; Smart D.D.K.; Bisht K.S.; Ho A.S.; Nguyen P. (10-26-2005). The epigenome as a molecular marker and target: Implications for cancer. Cancer, 104 (9) , 1789-1793More Information
Wang T.; Hui Y.C.; Dong S.; Fan M.; Tamae D.; Ozeki M.; Gao Q.; Gius D.; Jian J.L. (04-01-2005). Co-activation of ERK, NF-??, and GADD45? in response to ionizing radiation. Journal of Biological Chemistry, 280 (13) , 12593-12601More Information
Pennington J.; Wang T.; Nguyen P.; Sun L.; Bisht K.; Smart D.; Gius D. (01-01-2005). Redox-sensitive signaling factors as a novel molecular targets for cancer therapy. Drug Resistance Updates, 8 (5) , 322-330More Information
Bjornsson H.T.; Cui H.; Gius D.; Fallin M.D.; Feinberg A.P. (12-01-2004). The new field of epigenomics: Implications for cancer and other common disease research. Cold Spring Harbor Symposia on Quantitative Biology, 69, 447-456More Information
Smart D.D.K.; Ortiz K.L.; Mattson D.; Bradbury C.M.; Bisht K.S.; Sieck L.K.; Brechbiel M.W.; Gius D. (09-15-2004). Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative st. Cancer Research, 64 (18) , 6716-6724More Information
Spitz D.; Azzam E.; Li J.; Gius D. (08-01-2004). Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying con. Cancer and Metastasis Reviews, 23 (3-4) , 311-322More Information
Gius D.; Mattson D.; Bradbury C.M.; Smart D.K.; Spitz D.R. (03-01-2004). Thermal stress and the disruption of redox-sensitive signalling and transcription factor activation:. International Journal of Hyperthermia, 20 (2) , 213-223More Information
Lagunas L.; Bradbury C.; Laszlo A.; Hunt C.; Gius D. (01-23-2004). Indomethacin and ibuprofen induce Hsc70 nuclear localization and activation of the heat shock respon. Biochemical and Biophysical Research Communications, 313 (4) , 863-870More Information
Gius D. (01-01-2004). Redox-sensitive signaling factors and antioxidants: How tumor cells respond to ionizing radiation. Journal of Nutrition, 134 (11) More Information
Cook J.A.; Gius D.; Wink D.A.; Krishna M.C.; Russo A.; Mitchell J.B. (01-01-2004). Oxidative stress, redox, and the tumor microenvironment. Seminars in Radiation Oncology, 14 (3) , 259-266More Information
Mattson D.; Bradbury C.M.; Bisht K.S.; Curry H.A.; Spitz D.R.; Gius D. (01-01-2004). Heat shock and the activation of AP-1 and inhibition of NF-?B DNA-binding activity: Possible role of. International Journal of Hyperthermia, 20 (2) , 224-233More Information
Mimnaugh E.G.; Xu W.; Vos M.; Yuan X.; Isaacs J.S.; Bisht K.S.; Gius D.; Neckers L. (01-01-2004). Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endopla. Molecular Cancer Therapeutics, 3 (5) , 551-566More Information
Gius D.; Cui H.; Bradbury C.M.; Cook J.; Smart D.D.K.; Zhao S.; Young L.; Brandenburg S.A.; Hu Y.; Bisht K.S.; Ho A.S.; Mattson D.; Sun L.; Munson P.J.; Chuang E.Y.; Mitchell J.B.; Feinberg A.P. (01-01-2004). Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome rev. Cancer Cell, 6 (4) , 361-371More Information
Bisht K.S.; Bradbury C.M.; Mattson D.; Kaushal A.; Sowers A.; Markovina S.; Ortiz K.L.; Sieck L.K.; Isaacs J.S.; Brechbiel M.W.; Mitchell J.B.; Neckers L.M.; Gius D. (12-15-2003). Geldanamycin and 17-Allylamino-17-demethoxygeldanamycin Potentiate the in Vitro and in Vivo Radiatio. Cancer Research, 63 (24) , 8984-8995
Bisht K.; Bradbury C.; Zoberi I.; Curry H.; Kaushal A.; Roti Roti J.; Gius D. (11-01-2003). Inhibition of cyclooxygenase-2 with NS-398 and the prevention of radiation-induced transformation, m. International Journal of Radiation Biology, 79 (11) , 879-888More Information
Dewhirst M.W.; Sneed P.K.; Karimpour S.; Gius D. (10-01-2003). Those in gene therapy should pay closer attention to lessons from hyperthermia [5] (multiple letter). International Journal of Radiation Oncology Biology Physics, 57 (2) , 597-599More Information
Lin X.; Zhang F.; Bradbury C.M.; Kaushal A.; Li L.; Spitz D.R.; Aft R.L.; Gius D. (06-15-2003). 2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disrupt. Cancer Research, 63 (12) , 3413-3417
Karimpour S.; Gius D. (01-01-2003). The holy grail of radiation oncology: Lessons learned from hyperthermia. International Journal of Radiation Oncology Biology Physics, 55 (1) , 3-4More Information
Trimble E.; Schoenfeldt M.; Streicher H.; Gius D.; Cornelison T. (01-01-2003). Clinical Trials Referral Resource. Clinical trials in cervical cancer. Oncology Williston Park N Y, 17 (1) , 84-89
Ohiro Y.; Usheva A.; Kobayashi S.; Duffy S.; Nantz R.; Gius D.; Horikoshi N. (01-01-2003). Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53. Molecular and Cellular Biology, 23 (1) , 322-334More Information
Gius D.; Coleman C.N. (11-06-2002). Treatment of nasopharyngeal cancer: Raising the "Barr". Journal of the National Cancer Institute, 94 (21) , 1594-1595More Information
Ohiro Y.; Garkavtsev I.; Kobayashi S.; Sreekumar K.R.; Nantz R.; Higashikubo B.T.; Duffy S.L.; Higashikubo R.; Usheva A.; Gius D.; Kley N.; Horikoshi N. (07-31-2002). A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (. FEBS Letters, 524 (1-3) , 163-171More Information
Locke J.E.; Bradbury C.M.; Wei S.J.; Shah S.; Rene L.M.; Clemens R.A.; Roti J.R.; Horikoshi N.; Gius D. (07-04-2002). Indomethacin lowers the threshold thermal exposure for hyperthermic radiosensitization and heat-shoc. International Journal of Radiation Biology, 78 (6) , 493-502More Information
Sekhar K.; Spitz D.; Harris S.; Nguyen T.; Meredith M.; Holt J.; Gius D.; Marnett L.; Summar M.; Freeman M. (07-01-2002). Erratum: Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced express. Free Radical Biology and Medicine, 33 (1) , 149More Information
Sekhar K.R.; Spitz D.R.; Harris S.; Nguyen T.T.; Meredith M.J.; Holt J.T.; Guis D.; Marnett L.J.; Summar M.L.; Freeman M.L. (04-01-2002). Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of ?-. Free Radical Biology and Medicine, 32 (7) , 650-662More Information
Zoberi I.; Bradbury C.M.; Curry H.A.; Bisht K.S.; Goswami P.C.; Roti Roti J.L.; Gius D. (01-25-2002). Radiosensitizing and anti-proliferative effects of resveratrol in two human cervical tumor cell line. Cancer Letters, 175 (2) , 165-173More Information
Aft R.L.; Zhang F.W.; Gius D. (01-01-2002). Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: Mechanism of cell death. British Journal of Cancer, 87 (7) , 805-812More Information
Karimpour S.; Lou J.; Lin L.L.; Rene L.M.; Lagunas L.; Ma X.; Karra S.; Bradbury C.M.; Markovina S.; Goswami P.C.; Spitz D.R.; Hirota K.; Kalvakolanu D.V.; Yodoi J.; Gius D. (01-01-2002). Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active. Oncogene, 21 (41) , 6317-6327More Information
Markovina S.; Wei S.J.; Rene L.M.; Zoberi I.; Horikoshi N.; Bradbury C.M.; Gius D. (10-15-2001). Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-?B activatio. Cancer Research, 61 (20) , 7689-7696
Bradbury C.M.; Locke J.E.; Wei S.J.; Rene L.M.; Karimpour S.; Hunt C.; Spitz D.R.; Gius D. (04-15-2001). Increased activator protein 1 activity as well as resistance to heat-induced radiosensitization, hyd. Cancer Research, 61 (8) , 3486-3492
Goswami P.C.; Sheren J.; Albee L.D.; Parsian A.; Sim J.E.; Ridnour L.A.; Higashikubo R.; Gius D.; Hunt C.R.; Spitz D.R. (12-08-2000). Cell cycle-coupled variation in topoisomerase II? mRNA is regulated by the 3?-untranslated region: P. Journal of Biological Chemistry, 275 (49) , 38384-38392More Information
Roti Roti J.; Gius D.; VanderWaal R.; Xu M. (12-01-2000). Rearrangement of chromatin domains in cancer and development. Journal of Cellular Biochemistry, 80 (SUPPL. 35) , 54-60
Wei S.; Botero A.; Hirota K.; Bradbury C.; Markovina S.; Laszlo A.; Spitz D.; Goswami P.; Yodoi J.; Gius D. (12-01-2000). Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protei. Cancer Research, 60 (23) , 6688-6695
Curry H.A.; Clemens R.A.; Shah S.; Bradbury C.M.; Botero A.; Goswami P.; Gius D. (08-13-1999). Heat shock inhibits radiation-induced activation of NF-?B via inhibition of I-?B kinase. Journal of Biological Chemistry, 274 (33) , 23061-23067More Information
Diamond D.A.; Parsian A.; Hunt C.R.; Lofgren S.; Spitz D.R.; Goswami P.C.; Gius D. (06-11-1999). Redox factor-1 (Ref-1) mediates the activation of AP-1 in HeLa and NIH 3T3 cells in response to heat. Journal of Biological Chemistry, 274 (24) , 16959-16964More Information
Gius D.; Botero A.; Shah S.; Curry H.A. (06-01-1999). Intracellular oxidation/reduction status in the regulation of transcription factors NF-?B and AP-1. Toxicology Letters, 106 (2-3) , 93-106More Information
Gius D.R.; Ezhevsky S.A.; Becker-Hapak M.; Nagahara H.; Wei M.C.; Dowdy S.F. (06-01-1999). Transduced p16(INK4a) peptides inhibit hypophosphorylation of the retinoblastoma protein and cell cy. Cancer Research, 59 (11) , 2577-2580
Ezhevsky S.A.; Nagahara H.; Vocero-Akbani A.M.; Gius D.R.; Wei M.C.; Dowdy S.F. (09-30-1997). Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in act. Proceedings of the National Academy of Sciences of the United States of America, 94 (20) , 10699-10704More Information
Hallahan D.E.; Gius D.; Kuchibhotla J.; Sukhatme V.; Kufe D.W.; Weichselbaum R.R. (03-05-1993). Radiation signaling mediated by jun activation following dissociation from a cell type-specific repr. Journal of Biological Chemistry, 268 (7) , 4903-4907More Information
Rim M.; Qureshi S.A.; Gius D.; Nho J.; Sukhatme V.P.; Foster D.A. (01-01-1992). Evidence that activation of the Egr-1 promoter by v-Raf involves serum response elements. Oncogene, 7 (10) , 2069-2072
Gius D.; Cao X.; Rauscher F.; Cohen D.; Curran T.; Sukhatme V. (01-01-1990). Transcriptional activation and repression by fos are independent functions: The C terminus represses. Molecular and Cellular Biology, 10 (8) , 4243-4255More Information
Gius D.; Laimins L.A. (01-01-1989). Activation of human papillomavirus type 18 gene expression by herpes simplex virus type 1 viral tran. Journal of Virology, 63 (2) , 555-563More Information
Gius D.; Grossman S.; Bedell M.A.; Laimins L.A. (01-01-1988). Inducible and constitutive enhancer domains in the noncoding region of human papillomavirus type 18. Journal of Virology, 62 (3) , 665-672More Information