Jose Guadalupe Gomez-Arroyo, MD, PhD

Physician-scientist interested in pulmonary vascular diseases and their impact on the heart. Specialized on molecular biology, focused on animal models of pulmonary hypertension and emphysema. Interested in academic work and data science.

Medical Student: Escuela de Medicina Monterrey, NL, 2010

Doctoral Degree: Virginia Commonwealth University Richmond, VA, 2013 (Molecular Biology and Genetics)

Postdoctoral Research Fellowship: Johns Hopkins University Baltimore, MD, 2016 (Immunobiology, Vascular Biology)

Residency: University of Cincinnati Cincinnati, OH, 2019 (Internal Medicine)

Fellowship: University of Cincinnati Cincinnati, OH, 2022 (Pulmonary and Critical Care Medicine)

American Board of Internal Medicine (Certification Date: 12-14-2020 )

American Board of Internal Medicine (Pulmonary Disease) (Certification Date: 11-29-2022 )

American Board of Internal Medicine (Critical Care Medicine) (Certification Date: 11-14-2024 )

Critical Care Medicine

Lung Disease

Critical Care Medicine

Internal Medicine

Grant: #T32 Billing agreement Gomez -Arroyo Investigators:Gomez Arroyo, Jose 07-01-2022 -06-30-2023 National Heart, Lung and Blood Institute T32 Billing Agreement Gomez Arroyo Role:PI 66600.00 Hold Level:Federal

Grant: #PENDING Investigators:Gomez Arroyo, Jose 07-01-2023 -06-30-2024 Janssen Pharmaceutica Research Foundation Role of Foxf1 in the Pathobiology of Pulmonary Arterial Hypertension Role:PI 0.00 Hold Level:Industry

Investigators:Gomez Arroyo, Jose 07-01-2023 -06-30-2024 Cystic Fibrosis Foundation CFF RDP Role:PI 17804.87 Hold Level:Non Profit

Grant: #Fellowship Award Investigators:Gomez-Arroyo, Jose 07-01-2025 -06-30-2028 Parker B. Francis Foundation Role of FOXF1 in the Pathobiology of Pulmonary Arterial Hypertension Role:PI 75000.00 Hold Level:Non Profit

Peer Reviewed Publications

Best, Myron G; Sol, Nik; In 't Veld, Sjors G J G; Vancura, Adrienne; Muller, Mirte; Niemeijer, Anna-Larissa N; Fejes, Aniko V; Tjon Kon Fat, Lee-Ann; Huis In 't Veld, Anna E; Leurs, Cyra; Le Large, Tessa Y; Meijer, Laura L; Kooi, Irsan E; Rustenburg, François; Schellen, Pepijn; Verschueren, Heleen; Post, Edward; Wedekind, Laurine E; Bracht, Jillian; Esenkbrink, Michelle; Wils, Leon; Favaro, Francesca; Schoonhoven, Jilian D; Tannous, Jihane; Meijers-Heijboer, Hanne; Kazemier, Geert; Giovannetti, Elisa; Reijneveld, Jaap C; Idema, Sander; Killestein, Joep; Heger, Michal; de Jager, Saskia C; Urbanus, Rolf T; Hoefer, Imo E; Pasterkamp, Gerard; Mannhalter, Christine; Gomez-Arroyo, Jose; Bogaard, Harm-Jan; Noske, David P; Vandertop, W Peter; van den Broek, Daan; Ylstra, Bauke; Nilsson, R Jonas A; Wesseling, Pieter; Karachaliou, Niki; Rosell, Rafael; Lee-Lewandrowski, Elizabeth; Lewandrowski, Kent B; Tannous, Bakhos A; de Langen, Adrianus J; Smit, Egbert F; van den Heuvel, Michel M; Wurdinger, Thomas  (2017). Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets. Cancer cell, 32 (2) , 238-252.e9More Information

Mizuno, Shiro; Ishizaki, Takeshi; Kadowaki, Maiko; Akai, Masaya; Shiozaki, Kohei; Iguchi, Masaharu; Oikawa, Taku; Nakagawa, Ken; Osanai, Kazuhiro; Toga, Hirohisa; Gomez-Arroyo, Jose; Kraskauskas, Donatas; Cool, Carlyne D; Bogaard, Herman J; Voelkel, Norbert F  (2017). p53 Signaling Pathway Polymorphisms Associated With Emphysematous Changes in Patients With COPD. Chest, 152 (1) , 58-69More Information

Gomez-Arroyo, Jose; Abbate, Antonio; Voelkel, Norbert F  (2016). Pulmonary arterial hypertension and the Enigma code of smouldering inflammation. The European respiratory journal, 48 (2) , 305-7More Information

Sandoval, Julio; Gomez-Arroyo, Jose; Gaspar, Jorge; Pulido-Zamudio, Tomas  (2015). Interventional and surgical therapeutic strategies for pulmonary arterial hypertension: Beyond palliative treatments. Journal of cardiology, 66 (4) , 304-14More Information

Voelkel, Norbert F; Bogaard, Harm Jan; Gomez-Arroyo, Jose  (2015). The need to recognize the pulmonary circulation and the right ventricle as an integrated functional unit: facts and hypotheses (2013 Grover Conference series). Pulmonary circulation, 5 (1) , 81-9More Information

Gomez-Arroyo, Jose; Sakagami, Masahiro; Syed, Aamer A; Farkas, Laszlo; Van Tassell, Benjamin; Kraskauskas, Donatas; Mizuno, Shiro; Abbate, Antonio; Bogaard, Harm J; Byron, Peter R; Voelkel, Norbert F  (2015). Iloprost reverses established fibrosis in experimental right ventricular failure. The European respiratory journal, 45 (2) , 449-62More Information

Voelkel, Norbert F; Gomez-Arroyo, Jose  (2014). The role of vascular endothelial growth factor in pulmonary arterial hypertension. The angiogenesis paradox. American journal of respiratory cell and molecular biology, 51 (4) , 474-84More Information

Gomez-Arroyo, Jose; Sandoval, Julio; Simon, Marc A; Dominguez-Cano, Erick; Voelkel, Norbert F; Bogaard, Harm J  (2014). Treatment for pulmonary arterial hypertension-associated right ventricular dysfunction. Annals of the American Thoracic Society, 11 (7) , 1101-15More Information

de Raaf, Michiel Alexander; Schalij, Ingrid; Gomez-Arroyo, Jose; Rol, Nina; Happé, Chris; de Man, Frances S; Vonk-Noordegraaf, Anton; Westerhof, Nico; Voelkel, Norbert F; Bogaard, Harm Jan  (2014). SuHx rat model: partly reversible pulmonary hypertension and progressive intima obstruction. The European respiratory journal, 44 (1) , 160-8More Information

De Raaf, Michiel Alexander; Hussaini, Aysar Al; Gomez-Arroyo, Jose; Kraskaukas, Donatas; Farkas, Daniela; Happé, Chris; Voelkel, Norbert F; Bogaard, Harm Jan  (2014). Histone deacetylase inhibition with trichostatin A does not reverse severe angioproliferative pulmonary hypertension in rats (2013 Grover Conference series). Pulmonary circulation, 4 (2) , 237-43More Information

Gomez-Arroyo, Jose; Santos-Martinez, Luis E; Aranda, Alberto; Pulido, Tomas; Beltran, Miguel; Muñoz-Castellanos, Luis; Dominguez-Cano, Erick; Sonnino, Chiara; Voelkel, Norbert F; Sandoval, Julio  (2014). Differences in right ventricular remodeling secondary to pressure overload in patients with pulmonary hypertension. American journal of respiratory and critical care medicine, 189 (5) , 603-6More Information

Drake, Jennifer I; Gomez-Arroyo, Jose; Dumur, Catherine I; Kraskauskas, Donatas; Natarajan, Ramesh; Bogaard, Harm J; Fawcett, Paul; Voelkel, Norbert F  (2013). Chronic carvedilol treatment partially reverses the right ventricular failure transcriptional profile in experimental pulmonary hypertension. Physiological genomics, 45 (12) , 449-61More Information

Voelkel, Norbert F; Bogaard, Harm J; Al Husseini, Aysar; Farkas, Laszlo; Gomez-Arroyo, Jose; Natarajan, Ramesh  (2013). Antioxidants for the treatment of patients with severe angioproliferative pulmonary hypertension?. Antioxidants & redox signaling, 18 (14) , 1810-7More Information

Gomez-Arroyo, Jose; Mizuno, Shiro; Szczepanek, Karol; Van Tassell, Benjamin; Natarajan, Ramesh; dos Remedios, Cristobal G; Drake, Jennifer I; Farkas, Laszlo; Kraskauskas, Donatas; Wijesinghe, Dayanjan S; Chalfant, Charles E; Bigbee, John; Abbate, Antonio; Lesnefsky, Edward J; Bogaard, Harm J; Voelkel, Norbert F  (2013). Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension. Circulation. Heart failure, 6 (1) , 136-44More Information

Al Husseini, Aysar; Bagnato, Gianluca; Farkas, Laszlo; Gomez-Arroyo, Jose; Farkas, Daniela; Mizuno, Shiro; Kraskauskas, Donatas; Abbate, Antonio; Van Tassel, Benjamin; Voelkel, Norbert F; Bogaard, Harm Jan  (2013). Thyroid hormone is highly permissive in angioproliferative pulmonary hypertension in rats. The European respiratory journal, 41 (1) , 104-14More Information

Voelkel, Norbert F; Gomez-Arroyo, Jose; Abbate, Antonio; Bogaard, Harm J  (2013). Mechanisms of right heart failure-A work in progress and a plea for failure prevention. Pulmonary circulation, 3 (1) , 137-43More Information

Voelkel, Norbert F; Gomez-Arroyo, Jose; Abbate, Antonio; Bogaard, Harm J; Nicolls, Mark R  (2012). Pathobiology of pulmonary arterial hypertension and right ventricular failure. The European respiratory journal, 40 (6) , 1555-65More Information

Mizuno, Shiro; Farkas, Laszlo; Al Husseini, Aysar; Farkas, Daniela; Gomez-Arroyo, Jose; Kraskauskas, Donatas; Nicolls, Mark R; Cool, Carlyne D; Bogaard, Herman J; Voelkel, Norbert F  (2012). Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization. American journal of respiratory cell and molecular biology, 47 (5) , 679-87More Information

Nicolls, Mark R; Mizuno, Shiro; Taraseviciene-Stewart, Laima; Farkas, Laszlo; Drake, Jennnifer I; Al Husseini, Aysar; Gomez-Arroyo, Jose G; Voelkel, Norbert F; Bogaard, Herman J  (2012). New models of pulmonary hypertension based on VEGF receptor blockade-induced endothelial cell apoptosis. Pulmonary circulation, 2 (4) , 434-42More Information

Mizuno, Shiro; Bogaard, Harm J; Gomez-Arroyo, Jose; Alhussaini, Aysar; Kraskauskas, Donatas; Cool, Carlyne D; Voelkel, Norbert F  (2012). MicroRNA-199a-5p is associated with hypoxia-inducible factor-1? expression in lungs from patients with COPD. Chest, 142 (3) , 663-672More Information

Gomez-Arroyo, José; Voelkel, Norbert F; Bogaard, Harm J; Taraseviciene-Stewart, Laima  (2012). Usefulness of a mouse model of reversible pulmonary arterial hypertension: be cautious, choose carefully. American journal of respiratory and critical care medicine, 185 (12) , 1326; author reply 1More Information

Gomez-Arroyo, Jose; Saleem, Sheinei J; Mizuno, Shiro; Syed, Aamer A; Bogaard, Harm J; Abbate, Antonio; Taraseviciene-Stewart, Laimute; Sung, Yon; Kraskauskas, Donatas; Farkas, Daniela; Conrad, Daniel H; Nicolls, Mark R; Voelkel, Norbert F  (2012). A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects. American journal of physiology. Lung cellular and molecular physiology, 302 (10) , L977-91More Information

Bogaard, Harm J; Al Husseini, Aysar; Farkas, Laszlo; Farkas, Daniela; Gomez-Arroyo, Jose; Abbate, Antonio; Voelkel, Norbert FSevere pulmonary hypertension: The role of metabolic and endocrine disorders. Pulmonary circulation, 2 (2) , 148-54More Information

Van Tassell, Benjamin W; Bhardwaj, Hem L; Grizzard, John D; Kontos, Michael C; Bogaard, Herman; Gomez-Arroyo, Jose; Toldo, Stefano; Mezzaroma, Eleonora; Voelkel, Norbert F; Abbate, Antonio  (2012). Right ventricular systolic dysfunction in patients with reperfused ST-segment elevation acute myocardial infarction. International journal of cardiology, 155 (2) , 314-6More Information

Gomez-Arroyo, Jose G; Farkas, Laszlo; Alhussaini, Aysar A; Farkas, Daniela; Kraskauskas, Donatas; Voelkel, Norbert F; Bogaard, Harm J  (2012). The monocrotaline model of pulmonary hypertension in perspective. American journal of physiology. Lung cellular and molecular physiology, 302 (4) , L363-9More Information

Mizuno, Shiro; Yasuo, Masanori; Bogaard, Harm J; Kraskauskas, Donatas; Alhussaini, Aysar; Gomez-Arroyo, Jose; Farkas, Daniela; Farkas, Laszlo; Voelkel, Norbert F  (2012). Copper deficiency induced emphysema is associated with focal adhesion kinase inactivation. PloS one, 7 (1) , e30678More Information

Voelkel, N F; Gomez-Arroyo, J  (2011). The harmonics of rodent pulmonary hypertension models. International journal of clinical practice. Supplement (172) , 1-2More Information

Voelkel, Norbert F; Gomez-Arroyo, Jose; Mizuno, ShiroCOPD/emphysema: The vascular story. Pulmonary circulation, 1 (3) , 320-6More Information

Mizuno, Shiro; Bogaard, Herman J; Kraskauskas, Donatas; Alhussaini, Aysar; Gomez-Arroyo, Jose; Voelkel, Norbert F; Ishizaki, Takeshi  (2011). p53 Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice. American journal of physiology. Lung cellular and molecular physiology, 300 (5) , L753-61More Information