Jose Gomez-Arroyo

Jose Gomez-Arroyo

Fellow

Professional Summary

Physician-scientist interested in pulmonary vascular diseases and their impact on the heart. Specialized on molecular biology, focused on animal models of pulmonary hypertension and emphysema. Interested in academic work and data science.

Education

MD, Escuela de Medicina Ignacio A. Santos Mexico,

PhD, Virginia Commonwealth University

Research and Practice Interests

Publications

Peer Reviewed Publications

Best, Myron G; Sol, Nik; In 't Veld, Sjors G J G; Vancura, Adrienne; Muller, Mirte; Niemeijer, Anna-Larissa N; Fejes, Aniko V; Tjon Kon Fat, Lee-Ann; Huis In 't Veld, Anna E; Leurs, Cyra; Le Large, Tessa Y; Meijer, Laura L; Kooi, Irsan E; Rustenburg, François; Schellen, Pepijn; Verschueren, Heleen; Post, Edward; Wedekind, Laurine E; Bracht, Jillian; Esenkbrink, Michelle; Wils, Leon; Favaro, Francesca; Schoonhoven, Jilian D; Tannous, Jihane; Meijers-Heijboer, Hanne; Kazemier, Geert; Giovannetti, Elisa; Reijneveld, Jaap C; Idema, Sander; Killestein, Joep; Heger, Michal; de Jager, Saskia C; Urbanus, Rolf T; Hoefer, Imo E; Pasterkamp, Gerard; Mannhalter, Christine; Gomez-Arroyo, Jose; Bogaard, Harm-Jan; Noske, David P; Vandertop, W Peter; van den Broek, Daan; Ylstra, Bauke; Nilsson, R Jonas A; Wesseling, Pieter; Karachaliou, Niki; Rosell, Rafael; Lee-Lewandrowski, Elizabeth; Lewandrowski, Kent B; Tannous, Bakhos A; de Langen, Adrianus J; Smit, Egbert F; van den Heuvel, Michel M; Wurdinger, Thomas (2017. ) Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets.Cancer cell, , 32 (2 ) ,238-252.e9

Mizuno, Shiro; Ishizaki, Takeshi; Kadowaki, Maiko; Akai, Masaya; Shiozaki, Kohei; Iguchi, Masaharu; Oikawa, Taku; Nakagawa, Ken; Osanai, Kazuhiro; Toga, Hirohisa; Gomez-Arroyo, Jose; Kraskauskas, Donatas; Cool, Carlyne D; Bogaard, Herman J; Voelkel, Norbert F (2017. ) p53 Signaling Pathway Polymorphisms Associated With Emphysematous Changes in Patients With COPD.Chest, , 152 (1 ) ,58-69

Gomez-Arroyo, Jose; Abbate, Antonio; Voelkel, Norbert F (2016. ) Pulmonary arterial hypertension and the Enigma code of smouldering inflammation.The European respiratory journal, , 48 (2 ) ,305-7

Sandoval, Julio; Gomez-Arroyo, Jose; Gaspar, Jorge; Pulido-Zamudio, Tomas (2015. ) Interventional and surgical therapeutic strategies for pulmonary arterial hypertension: Beyond palliative treatments.Journal of cardiology, , 66 (4 ) ,304-14

Voelkel, Norbert F; Bogaard, Harm Jan; Gomez-Arroyo, Jose (2015. ) The need to recognize the pulmonary circulation and the right ventricle as an integrated functional unit: facts and hypotheses (2013 Grover Conference series).Pulmonary circulation, , 5 (1 ) ,81-9

Gomez-Arroyo, Jose; Sakagami, Masahiro; Syed, Aamer A; Farkas, Laszlo; Van Tassell, Benjamin; Kraskauskas, Donatas; Mizuno, Shiro; Abbate, Antonio; Bogaard, Harm J; Byron, Peter R; Voelkel, Norbert F (2015. ) Iloprost reverses established fibrosis in experimental right ventricular failure.The European respiratory journal, , 45 (2 ) ,449-62

Voelkel, Norbert F; Gomez-Arroyo, Jose (2014. ) The role of vascular endothelial growth factor in pulmonary arterial hypertension. The angiogenesis paradox.American journal of respiratory cell and molecular biology, , 51 (4 ) ,474-84

Gomez-Arroyo, Jose; Sandoval, Julio; Simon, Marc A; Dominguez-Cano, Erick; Voelkel, Norbert F; Bogaard, Harm J (2014. ) Treatment for pulmonary arterial hypertension-associated right ventricular dysfunction.Annals of the American Thoracic Society, , 11 (7 ) ,1101-15

de Raaf, Michiel Alexander; Schalij, Ingrid; Gomez-Arroyo, Jose; Rol, Nina; Happé, Chris; de Man, Frances S; Vonk-Noordegraaf, Anton; Westerhof, Nico; Voelkel, Norbert F; Bogaard, Harm Jan (2014. ) SuHx rat model: partly reversible pulmonary hypertension and progressive intima obstruction.The European respiratory journal, , 44 (1 ) ,160-8

De Raaf, Michiel Alexander; Hussaini, Aysar Al; Gomez-Arroyo, Jose; Kraskaukas, Donatas; Farkas, Daniela; Happé, Chris; Voelkel, Norbert F; Bogaard, Harm Jan (2014. ) Histone deacetylase inhibition with trichostatin A does not reverse severe angioproliferative pulmonary hypertension in rats (2013 Grover Conference series).Pulmonary circulation, , 4 (2 ) ,237-43

Gomez-Arroyo, Jose; Santos-Martinez, Luis E; Aranda, Alberto; Pulido, Tomas; Beltran, Miguel; Muñoz-Castellanos, Luis; Dominguez-Cano, Erick; Sonnino, Chiara; Voelkel, Norbert F; Sandoval, Julio (2014. ) Differences in right ventricular remodeling secondary to pressure overload in patients with pulmonary hypertension.American journal of respiratory and critical care medicine, , 189 (5 ) ,603-6

Drake, Jennifer I; Gomez-Arroyo, Jose; Dumur, Catherine I; Kraskauskas, Donatas; Natarajan, Ramesh; Bogaard, Harm J; Fawcett, Paul; Voelkel, Norbert F (2013. ) Chronic carvedilol treatment partially reverses the right ventricular failure transcriptional profile in experimental pulmonary hypertension.Physiological genomics, , 45 (12 ) ,449-61

Voelkel, Norbert F; Bogaard, Harm J; Al Husseini, Aysar; Farkas, Laszlo; Gomez-Arroyo, Jose; Natarajan, Ramesh (2013. ) Antioxidants for the treatment of patients with severe angioproliferative pulmonary hypertension?.Antioxidants & redox signaling, , 18 (14 ) ,1810-7

Gomez-Arroyo, Jose; Mizuno, Shiro; Szczepanek, Karol; Van Tassell, Benjamin; Natarajan, Ramesh; dos Remedios, Cristobal G; Drake, Jennifer I; Farkas, Laszlo; Kraskauskas, Donatas; Wijesinghe, Dayanjan S; Chalfant, Charles E; Bigbee, John; Abbate, Antonio; Lesnefsky, Edward J; Bogaard, Harm J; Voelkel, Norbert F (2013. ) Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension.Circulation. Heart failure, , 6 (1 ) ,136-44

Al Husseini, Aysar; Bagnato, Gianluca; Farkas, Laszlo; Gomez-Arroyo, Jose; Farkas, Daniela; Mizuno, Shiro; Kraskauskas, Donatas; Abbate, Antonio; Van Tassel, Benjamin; Voelkel, Norbert F; Bogaard, Harm Jan (2013. ) Thyroid hormone is highly permissive in angioproliferative pulmonary hypertension in rats.The European respiratory journal, , 41 (1 ) ,104-14

Voelkel, Norbert F; Gomez-Arroyo, Jose; Abbate, Antonio; Bogaard, Harm J (2013. ) Mechanisms of right heart failure-A work in progress and a plea for failure prevention.Pulmonary circulation, , 3 (1 ) ,137-43

Voelkel, Norbert F; Gomez-Arroyo, Jose; Abbate, Antonio; Bogaard, Harm J; Nicolls, Mark R (2012. ) Pathobiology of pulmonary arterial hypertension and right ventricular failure.The European respiratory journal, , 40 (6 ) ,1555-65

Mizuno, Shiro; Farkas, Laszlo; Al Husseini, Aysar; Farkas, Daniela; Gomez-Arroyo, Jose; Kraskauskas, Donatas; Nicolls, Mark R; Cool, Carlyne D; Bogaard, Herman J; Voelkel, Norbert F (2012. ) Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization.American journal of respiratory cell and molecular biology, , 47 (5 ) ,679-87

Nicolls, Mark R; Mizuno, Shiro; Taraseviciene-Stewart, Laima; Farkas, Laszlo; Drake, Jennnifer I; Al Husseini, Aysar; Gomez-Arroyo, Jose G; Voelkel, Norbert F; Bogaard, Herman J (2012. ) New models of pulmonary hypertension based on VEGF receptor blockade-induced endothelial cell apoptosis.Pulmonary circulation, , 2 (4 ) ,434-42

Mizuno, Shiro; Bogaard, Harm J; Gomez-Arroyo, Jose; Alhussaini, Aysar; Kraskauskas, Donatas; Cool, Carlyne D; Voelkel, Norbert F (2012. ) MicroRNA-199a-5p is associated with hypoxia-inducible factor-1? expression in lungs from patients with COPD.Chest, , 142 (3 ) ,663-672

Gomez-Arroyo, José; Voelkel, Norbert F; Bogaard, Harm J; Taraseviciene-Stewart, Laima (2012. ) Usefulness of a mouse model of reversible pulmonary arterial hypertension: be cautious, choose carefully.American journal of respiratory and critical care medicine, , 185 (12 ) ,1326; author reply 1

Gomez-Arroyo, Jose; Saleem, Sheinei J; Mizuno, Shiro; Syed, Aamer A; Bogaard, Harm J; Abbate, Antonio; Taraseviciene-Stewart, Laimute; Sung, Yon; Kraskauskas, Donatas; Farkas, Daniela; Conrad, Daniel H; Nicolls, Mark R; Voelkel, Norbert F (2012. ) A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects.American journal of physiology. Lung cellular and molecular physiology, , 302 (10 ) ,L977-91

Bogaard, Harm J; Al Husseini, Aysar; Farkas, Laszlo; Farkas, Daniela; Gomez-Arroyo, Jose; Abbate, Antonio; Voelkel, Norbert F Severe pulmonary hypertension: The role of metabolic and endocrine disorders.Pulmonary circulation, , 2 (2 ) ,148-54

Van Tassell, Benjamin W; Bhardwaj, Hem L; Grizzard, John D; Kontos, Michael C; Bogaard, Herman; Gomez-Arroyo, Jose; Toldo, Stefano; Mezzaroma, Eleonora; Voelkel, Norbert F; Abbate, Antonio (2012. ) Right ventricular systolic dysfunction in patients with reperfused ST-segment elevation acute myocardial infarction.International journal of cardiology, , 155 (2 ) ,314-6

Gomez-Arroyo, Jose G; Farkas, Laszlo; Alhussaini, Aysar A; Farkas, Daniela; Kraskauskas, Donatas; Voelkel, Norbert F; Bogaard, Harm J (2012. ) The monocrotaline model of pulmonary hypertension in perspective.American journal of physiology. Lung cellular and molecular physiology, , 302 (4 ) ,L363-9

Mizuno, Shiro; Yasuo, Masanori; Bogaard, Harm J; Kraskauskas, Donatas; Alhussaini, Aysar; Gomez-Arroyo, Jose; Farkas, Daniela; Farkas, Laszlo; Voelkel, Norbert F (2012. ) Copper deficiency induced emphysema is associated with focal adhesion kinase inactivation.PloS one, , 7 (1 ) ,e30678

Voelkel, N F; Gomez-Arroyo, J (2011. ) The harmonics of rodent pulmonary hypertension models.International journal of clinical practice. Supplement, , (172 ) ,1-2

Voelkel, Norbert F; Gomez-Arroyo, Jose; Mizuno, Shiro COPD/emphysema: The vascular story.Pulmonary circulation, , 1 (3 ) ,320-6

Mizuno, Shiro; Bogaard, Herman J; Kraskauskas, Donatas; Alhussaini, Aysar; Gomez-Arroyo, Jose; Voelkel, Norbert F; Ishizaki, Takeshi (2011. ) p53 Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice.American journal of physiology. Lung cellular and molecular physiology, , 300 (5 ) ,L753-61

Post Graduate Training and Education

2014-2016 Postdoctoral research fellow, Immunobiology, vascular biology, resistin, Johns Hopkins University, , Baltimore, MD

2010-2013 Graduate school, PhD in Molecular Biology and Genetics. My work at Dr. Voelkel’s laboratory was mainly focused on characterizing the cellular and molecular changes of right ventricular dysfunction in the setting of severe pulmonary hypertension. Most of my work described changes in cardiac substrate utilization and mitochondrial dysfunction in the failing RV. Moreover, we aimed to explain other features present in maladaptive right ventricular hypertrophy such as extracelular matrix remodelling, impaired angiogenesis and oxidative stress damage, among others. Altogether, my main goal is to better understand the pathobiology of pulmonary arterial hypertension and its associated right ventricular failure as well as to test or develop new treatments directed to improve or restore right ventricular function in the setting of chronic pressure overload. , Virginia Commonwealth University, , Richmond, VA

2003-2010 Medical Student, Escuela de Medicina "Ignacio Santos" Tecnológico de Monterrey, , Monterrey, Nuevo Leon, Mexico