Expert Profile: June Goto | Research Directory

Education

PhD: University of Tokyo Tokyo, Japan, 2006 (Medical Science)

Positions and Work Experience

2019 - Assistant Professor , Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH

2013 -2019 Instructor, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH

2007 -2012 Research fellow, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

Publications

Peer Reviewed Publications

Duy, Phan Q; Weise, Stefan C; Marini, Claudia; Li, Xiao-Jun; Liang, Dan; Dahl, Peter J; Ma, Shaojie; Spajic, Ana; Dong, Weilai; Juusola, Jane; Kiziltug, Emre; Kundishora, Adam J; Koundal, Sunil; Pedram, Maysam Z; Torres-Fernández, Lucia A; Händler, Kristian; De Domenico, Elena; Becker, Matthias; Ulas, Thomas; Juranek, Stefan A; Cuevas, Elisa; Hao, Le Thi; Jux, Bettina; Sousa, André M M; Liu, Fuchen; Kim, Suel-Kee; Li, Mingfeng; Yang, Yiying; Takeo, Yutaka; Duque, Alvaro; Nelson-Williams, Carol; Ha, Yonghyun; Selvaganesan, Kartiga; Robert, Stephanie M; Singh, Amrita K; Allington, Garrett; Furey, Charuta G; Timberlake, Andrew T; Reeves, Benjamin C; Smith, Hannah; Dunbar, Ashley; DeSpenza, Tyrone; Goto, June; Marlier, Arnaud; Moreno-De-Luca, Andres; Yu, Xin; Butler, William E; Carter, Bob S; Lake, Evelyn M R; Constable, R Todd; Rakic, Pasko; Lin, Haifan; Deniz, Engin; Benveniste, Helene; Malvankar, Nikhil S; Estrada-Veras, Juvianee I; Walsh, Christopher A; Alper, Seth L; Schultze, Joachim L; Paeschke, Katrin; Doetzlhofer, Angelika; Wulczyn, F Gregory; Jin, Sheng Chih; Lifton, Richard P; Sestan, Nenad; Kolanus, Waldemar; Kahle, Kristopher T (2022. ) Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus.Nature neuroscience, , 25 (4 ) ,458-473 More Information

Iwasawa, Eri; Brown, Farrah N; Shula, Crystal; Kahn, Fatima; Lee, Sang Hoon; Berta, Temugin; Ladle, David R; Campbell, Kenneth; Mangano, Francesco T; Goto, June (2022. ) The Anti-Inflammatory Agent Bindarit Attenuates the Impairment of Neural Development through Suppression of Microglial Activation in a Neonatal Hydrocephalus Mouse Model.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 42 (9 ) ,1820-1844 More Information

Bedolla, Alicia; Taranov, Aleksandr; Luo, Fucheng; Wang, Jiapeng; Turcato, Flavia; Fugate, Elizabeth M; Greig, Nigel H; Lindquist, Diana M; Crone, Steven A; Goto, June; Luo, Yu (2022. ) Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulation.Journal of neuroinflammation, , 19 (1 ) ,3 More Information

Neupane, Sanjiv; Goto, June; Berardinelli, Steven J; Ito, Atsuko; Haltiwanger, Robert S; Holdener, Bernadette C (2021. ) Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ.Glycobiology, , 31 (8 ) ,988-1004 More Information

Jin, Sheng Chih; Dong, Weilai; Kundishora, Adam J; Panchagnula, Shreyas; Moreno-De-Luca, Andres; Furey, Charuta G; Allocco, August A; Walker, Rebecca L; Nelson-Williams, Carol; Smith, Hannah; Dunbar, Ashley; Conine, Sierra; Lu, Qiongshi; Zeng, Xue; Sierant, Michael C; Knight, James R; Sullivan, William; Duy, Phan Q; DeSpenza, Tyrone; Reeves, Benjamin C; Karimy, Jason K; Marlier, Arnaud; Castaldi, Christopher; Tikhonova, Irina R; Li, Boyang; Peña, Helena Perez; Broach, James R; Kabachelor, Edith M; Ssenyonga, Peter; Hehnly, Christine; Ge, Li; Keren, Boris; Timberlake, Andrew T; Goto, June; Mangano, Francesco T; Johnston, James M; Butler, William E; Warf, Benjamin C; Smith, Edward R; Schiff, Steven J; Limbrick, David D; Heuer, Gregory; Jackson, Eric M; Iskandar, Bermans J; Mane, Shrikant; Haider, Shozeb; Guclu, Bulent; Bayri, Yasar; Sahin, Yener; Duncan, Charles C; Apuzzo, Michael L J; DiLuna, Michael L; Hoffman, Ellen J; Sestan, Nenad; Ment, Laura R; Alper, Seth L; Bilguvar, Kaya; Geschwind, Daniel H; Günel, Murat; Lifton, Richard P; Kahle, Kristopher T (2020. ) Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus.Nature medicine, , 26 (11 ) ,1754-1765 More Information

Goulding, Danielle S; Vogel, R Caleb; Pandya, Chirayu D; Shula, Crystal; Gensel, John C; Mangano, Francesco T; Goto, June; Miller, Brandon A (2020. ) Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice.Journal of neurosurgery. Pediatrics, , 1-8 More Information

Emmert, A Scott; Iwasawa, Eri; Shula, Crystal; Schultz, Preston; Lindquist, Diana; Dunn, R Scott; Fugate, Elizabeth M; Hu, Yueh-Chiang; Mangano, Francesco T; Goto, June (2019. ) Impaired neural differentiation and glymphatic CSF flow in the Ccdc39 rat model of neonatal hydrocephalus: genetic interaction with L1cam.Disease models & mechanisms, , 12 (11 ) , More Information

Emmert, A Scott; Vuong, Shawn M; Shula, Crystal; Lindquist, Diana; Yuan, Weihong; Hu, Yueh-Chiang; Mangano, Francesco T; Goto, June (2019. ) Characterization of a novel rat model of X-linked hydrocephalus by CRISPR-mediated mutation in L1cam.Journal of neurosurgery, , 132 (3 ) ,945-958 More Information

Abdelhamed, Zakia; Vuong, Shawn M; Hill, Lauren; Shula, Crystal; Timms, Andrew; Beier, David; Campbell, Kenneth; Mangano, Francesco T; Stottmann, Rolf W; Goto, June (2018. ) A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice.Development (Cambridge, England), , 145 (1 ) , More Information

Hu, Zhongdong; Wang, Ying; Huang, Fuqiang; Chen, Rongrong; Li, Chunjia; Wang, Fang; Goto, June; Kwiatkowski, David J; Wdzieczak-Bakala, Joanna; Tu, Pengfei; Liu, Jianmiao; Zha, Xiaojun; Zhang, Hongbing (2015. ) Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis.The Journal of biological chemistry, , 290 (42 ) ,25756-65 More Information

Prabhakar, Shilpa; Goto, June; Zhang, Xuan; Zuang, Xuan; Sena-Esteves, Miguel; Bronson, Roderick; Brockmann, Jillian; Gianni, Davide; Wojtkiewicz, Gregory R; Chen, John W; Stemmer-Rachamimov, Anat; Kwiatkowski, David J; Breakefield, Xandra O (2013. ) Stochastic model of Tsc1 lesions in mouse brain.PloS one, , 8 (5 ) ,e64224 More Information

Goto, June; Tezuka, Tohru; Nakazawa, Takanobu; Sagara, Hiroshi; Yamamoto, Tadashi (2008. ) Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development.Molecular and cellular neurosciences, , 38 (2 ) ,203-12 More Information

Nakazawa, Takanobu; Komai, Shoji; Watabe, Ayako M; Kiyama, Yuji; Fukaya, Masahiro; Arima-Yoshida, Fumiko; Horai, Reiko; Sudo, Katsuko; Ebine, Kazumi; Delawary, Mina; Goto, June; Umemori, Hisashi; Tezuka, Tohru; Iwakura, Yoichiro; Watanabe, Masahiko; Yamamoto, Tadashi; Manabe, Toshiya (2006. ) NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.The EMBO journal, , 25 (12 ) ,2867-77 More Information

Goto, June; Tezuka, Tohru; Nakazawa, Takanobu; Tsukamoto, Nobuo; Nakamura, Takahisa; Ajima, Rieko; Yokoyama, Kazumasa; Ohta, Tsutomu; Ohki, Misao; Yamamoto, Tadashi (2004. ) Altered gene expression in the adult brain of fyn-deficient mice.Cellular and molecular neurobiology, , 24 (1 ) ,149-59 More Information

Prabhakar, Shilpa; Zhang, Xuan; Goto, June; Han, Sangyeul; Lai, Charles; Bronson, Roderick; Sena-Esteves, Miguel; Ramesh, Vijaya; Stemmer-Rachamimov, Anat; Kwiatkowski, David J; Breakefield, Xandra O (2015. ) Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model.Neurobiology of disease, , 82 ,22-31 More Information

Di Nardo, Alessia; Wertz, Mary H; Kwiatkowski, Erica; Tsai, Peter T; Leech, Jarrett D; Greene-Colozzi, Emily; Goto, June; Dilsiz, Pelin; Talos, Delia M; Clish, Clary B; Kwiatkowski, David J; Sahin, Mustafa (2014. ) Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1.Human molecular genetics, , 23 (14 ) ,3865-74 More Information

Tsai, Peter T; Greene-Colozzi, Emily; Goto, June; Anderl, Stefanie; Kwiatkowski, David J; Sahin, Mustafa (2013. ) Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice.Behavior genetics, , 43 (1 ) ,51-9 More Information

Anderl, Stefanie; Freeland, Megan; Kwiatkowski, David J; Goto, June (2011. ) Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex.Human molecular genetics, , 20 (23 ) ,4597-604 More Information

Goto, June; Talos, Delia M; Klein, Peter; Qin, Wei; Chekaluk, Yvonne I; Anderl, Stefanie; Malinowska, Izabela A; Di Nardo, Alessia; Bronson, Roderick T; Chan, Jennifer A; Vinters, Harry V; Kernie, Steven G; Jensen, Frances E; Sahin, Mustafa; Kwiatkowski, David J (2011. ) Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex.Proceedings of the National Academy of Sciences of the United States of America, , 108 (45 ) ,E1070-9 More Information

Malhowski, Amy J; Hira, Haider; Bashiruddin, Sarah; Warburton, Rod; Goto, June; Robert, Blanton; Kwiatkowski, David J; Finlay, Geraldine A (2011. ) Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin.Human molecular genetics, , 20 (7 ) ,1290-305 More Information

Sun, Qian; Chen, Xinxin; Ma, Jianhui; Peng, Haiyong; Wang, Fang; Zha, Xiaojun; Wang, Yanan; Jing, Yanling; Yang, Hongwang; Chen, Rongrong; Chang, Long; Zhang, Yu; Goto, June; Onda, Hiroaki; Chen, Tong; Wang, Ming-Rong; Lu, Youyong; You, Han; Kwiatkowski, David; Zhang, Hongbing (2011. ) Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.Proceedings of the National Academy of Sciences of the United States of America, , 108 (10 ) ,4129-34 More Information

Liang, M-C; Ma, J; Chen, L; Kozlowski, P; Qin, W; Li, D; Goto, J; Shimamura, T; Hayes, D N; Meyerson, M; Kwiatkowski, D J; Wong, K-K (2010. ) TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity.Oncogene, , 29 (11 ) ,1588-97 More Information

Pollizzi, Kristen; Malinowska-Kolodziej, Izabela; Doughty, Cheryl; Betz, Charles; Ma, Jian; Goto, June; Kwiatkowski, David J (2009. ) A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.Human molecular genetics, , 18 (13 ) ,2378-87 More Information