June Goto , PhD

Currently, my research focus on roles of microglial subgroups during the perinatal brain development and the mechanisms of actions for therapeutic effects of anti-inflammatory drug in the periventricular white matter damage using several animal models of neonatal hydrocephalus. In our most recent two publications we found that potential cellular mechanisms to control functions of temporal microglia subgroup during development “CD11c+” or “primed” microglia in neonatal hydrocephalus. We are investigating the subtypes of microglia that appers in neonatal hydrocephalus with white matter injury. 

We also study the effects of choroid plexus removal for the treatment of neonatal hydrocephalus using rodents. 

PhD: The University of Tokyo Tokyo, Japan, 2006 (Medical Science)

MS : The University of Tokyo Tokyo, Japan, 2002 (Medical Science)

BS: Tokyo Gakugei University Tokyo, Japan, 2000 (Education and Biology)

2019 - Assistant Professor , Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH

2013 -2019 Instructor, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH

2007 -2012 Research fellow, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

2006 -2007 JSPS Postdoctral Fellow, Institute of Medical Science, the University of Tokyo, Tokyo, Japan

Grant: #R21NS127177 Investigators:Luo, Y and Goto J 09-2022 -08-2024 NINDS Ablating choroid plexus epithelial cells in the developing mouse brain: A new tool to approach CSF disorders Role:PI $456,877 Completed Type:Grant

Grant: #1R61NS138647 Investigators:June Goto, Francesco Mangano 09-18-2024 -08-30-2026 NINDS Novel biologics to ablate choroid plexus for the treatment of neonatal hydrocephalus Role:PI $774,007 Active Type:Grant

Peer Reviewed Publications

Brown, Farrah N; Iwasawa, Eri; Shula, Crystal; Fugate, Elizabeth M; Lindquist, Diana M; Mangano, Francesco T; Goto, June (2023. ) Early postnatal microglial ablation in the Ccdc39 mouse model reveals adverse effects on brain development and in neonatal hydrocephalus.Fluids and barriers of the CNS, , 20 (1 ) ,42 More Information

Duy, Phan Q; Weise, Stefan C; Marini, Claudia; Li, Xiao-Jun; Liang, Dan; Dahl, Peter J; Ma, Shaojie; Spajic, Ana; Dong, Weilai; Juusola, Jane; Kiziltug, Emre; Kundishora, Adam J; Koundal, Sunil; Pedram, Maysam Z; Torres-Fernández, Lucia A; Händler, Kristian; De Domenico, Elena; Becker, Matthias; Ulas, Thomas; Juranek, Stefan A; Cuevas, Elisa; Hao, Le Thi; Jux, Bettina; Sousa, André M M; Liu, Fuchen; Kim, Suel-Kee; Li, Mingfeng; Yang, Yiying; Takeo, Yutaka; Duque, Alvaro; Nelson-Williams, Carol; Ha, Yonghyun; Selvaganesan, Kartiga; Robert, Stephanie M; Singh, Amrita K; Allington, Garrett; Furey, Charuta G; Timberlake, Andrew T; Reeves, Benjamin C; Smith, Hannah; Dunbar, Ashley; DeSpenza, Tyrone; Goto, June; Marlier, Arnaud; Moreno-De-Luca, Andres; Yu, Xin; Butler, William E; Carter, Bob S; Lake, Evelyn M R; Constable, R Todd; Rakic, Pasko; Lin, Haifan; Deniz, Engin; Benveniste, Helene; Malvankar, Nikhil S; Estrada-Veras, Juvianee I; Walsh, Christopher A; Alper, Seth L; Schultze, Joachim L; Paeschke, Katrin; Doetzlhofer, Angelika; Wulczyn, F Gregory; Jin, Sheng Chih; Lifton, Richard P; Sestan, Nenad; Kolanus, Waldemar; Kahle, Kristopher T (2022. ) Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus.Nature neuroscience, , 25 (4 ) ,458-473 More Information

Iwasawa, Eri; Brown, Farrah N; Shula, Crystal; Kahn, Fatima; Lee, Sang Hoon; Berta, Temugin; Ladle, David R; Campbell, Kenneth; Mangano, Francesco T; Goto, June (2022. ) The Anti-Inflammatory Agent Bindarit Attenuates the Impairment of Neural Development through Suppression of Microglial Activation in a Neonatal Hydrocephalus Mouse Model.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 42 (9 ) ,1820-1844 More Information

Bedolla, Alicia; Taranov, Aleksandr; Luo, Fucheng; Wang, Jiapeng; Turcato, Flavia; Fugate, Elizabeth M; Greig, Nigel H; Lindquist, Diana M; Crone, Steven A; Goto, June; Luo, Yu (2022. ) Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulation.Journal of neuroinflammation, , 19 (1 ) ,3 More Information

Neupane, Sanjiv; Goto, June; Berardinelli, Steven J; Ito, Atsuko; Haltiwanger, Robert S; Holdener, Bernadette C (2021. ) Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ.Glycobiology, , 31 (8 ) ,988-1004 More Information

Jin, Sheng Chih; Dong, Weilai; Kundishora, Adam J; Panchagnula, Shreyas; Moreno-De-Luca, Andres; Furey, Charuta G; Allocco, August A; Walker, Rebecca L; Nelson-Williams, Carol; Smith, Hannah; Dunbar, Ashley; Conine, Sierra; Lu, Qiongshi; Zeng, Xue; Sierant, Michael C; Knight, James R; Sullivan, William; Duy, Phan Q; DeSpenza, Tyrone; Reeves, Benjamin C; Karimy, Jason K; Marlier, Arnaud; Castaldi, Christopher; Tikhonova, Irina R; Li, Boyang; Peña, Helena Perez; Broach, James R; Kabachelor, Edith M; Ssenyonga, Peter; Hehnly, Christine; Ge, Li; Keren, Boris; Timberlake, Andrew T; Goto, June; Mangano, Francesco T; Johnston, James M; Butler, William E; Warf, Benjamin C; Smith, Edward R; Schiff, Steven J; Limbrick, David D; Heuer, Gregory; Jackson, Eric M; Iskandar, Bermans J; Mane, Shrikant; Haider, Shozeb; Guclu, Bulent; Bayri, Yasar; Sahin, Yener; Duncan, Charles C; Apuzzo, Michael L J; DiLuna, Michael L; Hoffman, Ellen J; Sestan, Nenad; Ment, Laura R; Alper, Seth L; Bilguvar, Kaya; Geschwind, Daniel H; Günel, Murat; Lifton, Richard P; Kahle, Kristopher T (2020. ) Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus.Nature medicine, , 26 (11 ) ,1754-1765 More Information

Goulding, Danielle S; Vogel, R Caleb; Pandya, Chirayu D; Shula, Crystal; Gensel, John C; Mangano, Francesco T; Goto, June; Miller, Brandon A (2020. ) Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice.Journal of neurosurgery. Pediatrics, , 1-8 More Information

Emmert, A Scott; Iwasawa, Eri; Shula, Crystal; Schultz, Preston; Lindquist, Diana; Dunn, R Scott; Fugate, Elizabeth M; Hu, Yueh-Chiang; Mangano, Francesco T; Goto, June (2019. ) Impaired neural differentiation and glymphatic CSF flow in the Ccdc39 rat model of neonatal hydrocephalus: genetic interaction with L1cam.Disease models & mechanisms, , 12 (11 ) , More Information

Emmert, A Scott; Vuong, Shawn M; Shula, Crystal; Lindquist, Diana; Yuan, Weihong; Hu, Yueh-Chiang; Mangano, Francesco T; Goto, June (2019. ) Characterization of a novel rat model of X-linked hydrocephalus by CRISPR-mediated mutation in L1cam.Journal of neurosurgery, , 132 (3 ) ,945-958 More Information

Abdelhamed, Zakia; Vuong, Shawn M; Hill, Lauren; Shula, Crystal; Timms, Andrew; Beier, David; Campbell, Kenneth; Mangano, Francesco T; Stottmann, Rolf W; Goto, June (2018. ) A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice.Development (Cambridge, England), , 145 (1 ) , More Information

Hu, Zhongdong; Wang, Ying; Huang, Fuqiang; Chen, Rongrong; Li, Chunjia; Wang, Fang; Goto, June; Kwiatkowski, David J; Wdzieczak-Bakala, Joanna; Tu, Pengfei; Liu, Jianmiao; Zha, Xiaojun; Zhang, Hongbing (2015. ) Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis.The Journal of biological chemistry, , 290 (42 ) ,25756-65 More Information

Prabhakar, Shilpa; Zhang, Xuan; Goto, June; Han, Sangyeul; Lai, Charles; Bronson, Roderick; Sena-Esteves, Miguel; Ramesh, Vijaya; Stemmer-Rachamimov, Anat; Kwiatkowski, David J; Breakefield, Xandra O (2015. ) Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model.Neurobiology of disease, , 82 ,22-31 More Information

Prabhakar, Shilpa; Zhang, Xuan; Goto, June; Han, Sangyeul; Lai, Charles; Bronson, Roderick; Sena-Esteves, Miguel; Ramesh, Vijaya; Stemmer-Rachamimov, Anat; Kwiatkowski, David J; Breakefield, Xandra O (2015. ) Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model.Neurobiology of disease, , 82 ,22-31 More Information

Di Nardo, Alessia; Wertz, Mary H; Kwiatkowski, Erica; Tsai, Peter T; Leech, Jarrett D; Greene-Colozzi, Emily; Goto, June; Dilsiz, Pelin; Talos, Delia M; Clish, Clary B; Kwiatkowski, David J; Sahin, Mustafa (2014. ) Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1.Human molecular genetics, , 23 (14 ) ,3865-74 More Information

Di Nardo, Alessia; Wertz, Mary H; Kwiatkowski, Erica; Tsai, Peter T; Leech, Jarrett D; Greene-Colozzi, Emily; Goto, June; Dilsiz, Pelin; Talos, Delia M; Clish, Clary B; Kwiatkowski, David J; Sahin, Mustafa (2014. ) Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1.Human molecular genetics, , 23 (14 ) ,3865-74 More Information

Tsai, Peter T; Greene-Colozzi, Emily; Goto, June; Anderl, Stefanie; Kwiatkowski, David J; Sahin, Mustafa (2013. ) Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice.Behavior genetics, , 43 (1 ) ,51-9 More Information

Prabhakar, Shilpa; Goto, June; Zhang, Xuan; Zuang, Xuan; Sena-Esteves, Miguel; Bronson, Roderick; Brockmann, Jillian; Gianni, Davide; Wojtkiewicz, Gregory R; Chen, John W; Stemmer-Rachamimov, Anat; Kwiatkowski, David J; Breakefield, Xandra O (2013. ) Stochastic model of Tsc1 lesions in mouse brain.PloS one, , 8 (5 ) ,e64224 More Information

Tsai, Peter T; Greene-Colozzi, Emily; Goto, June; Anderl, Stefanie; Kwiatkowski, David J; Sahin, Mustafa (2013. ) Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice.Behavior genetics, , 43 (1 ) ,51-9 More Information

Anderl, Stefanie; Freeland, Megan; Kwiatkowski, David J; Goto, June (2011. ) Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex.Human molecular genetics, , 20 (23 ) ,4597-604 More Information

Goto, June; Talos, Delia M; Klein, Peter; Qin, Wei; Chekaluk, Yvonne I; Anderl, Stefanie; Malinowska, Izabela A; Di Nardo, Alessia; Bronson, Roderick T; Chan, Jennifer A; Vinters, Harry V; Kernie, Steven G; Jensen, Frances E; Sahin, Mustafa; Kwiatkowski, David J (2011. ) Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex.Proceedings of the National Academy of Sciences of the United States of America, , 108 (45 ) ,E1070-9 More Information

Malhowski, Amy J; Hira, Haider; Bashiruddin, Sarah; Warburton, Rod; Goto, June; Robert, Blanton; Kwiatkowski, David J; Finlay, Geraldine A (2011. ) Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin.Human molecular genetics, , 20 (7 ) ,1290-305 More Information

Sun, Qian; Chen, Xinxin; Ma, Jianhui; Peng, Haiyong; Wang, Fang; Zha, Xiaojun; Wang, Yanan; Jing, Yanling; Yang, Hongwang; Chen, Rongrong; Chang, Long; Zhang, Yu; Goto, June; Onda, Hiroaki; Chen, Tong; Wang, Ming-Rong; Lu, Youyong; You, Han; Kwiatkowski, David; Zhang, Hongbing (2011. ) Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.Proceedings of the National Academy of Sciences of the United States of America, , 108 (10 ) ,4129-34 More Information

Anderl, Stefanie; Freeland, Megan; Kwiatkowski, David J; Goto, June (2011. ) Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex.Human molecular genetics, , 20 (23 ) ,4597-604 More Information

Goto, June; Talos, Delia M; Klein, Peter; Qin, Wei; Chekaluk, Yvonne I; Anderl, Stefanie; Malinowska, Izabela A; Di Nardo, Alessia; Bronson, Roderick T; Chan, Jennifer A; Vinters, Harry V; Kernie, Steven G; Jensen, Frances E; Sahin, Mustafa; Kwiatkowski, David J (2011. ) Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex.Proceedings of the National Academy of Sciences of the United States of America, , 108 (45 ) ,E1070-9 More Information

Malhowski, Amy J; Hira, Haider; Bashiruddin, Sarah; Warburton, Rod; Goto, June; Robert, Blanton; Kwiatkowski, David J; Finlay, Geraldine A (2011. ) Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin.Human molecular genetics, , 20 (7 ) ,1290-305 More Information

Sun, Qian; Chen, Xinxin; Ma, Jianhui; Peng, Haiyong; Wang, Fang; Zha, Xiaojun; Wang, Yanan; Jing, Yanling; Yang, Hongwang; Chen, Rongrong; Chang, Long; Zhang, Yu; Goto, June; Onda, Hiroaki; Chen, Tong; Wang, Ming-Rong; Lu, Youyong; You, Han; Kwiatkowski, David; Zhang, Hongbing (2011. ) Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.Proceedings of the National Academy of Sciences of the United States of America, , 108 (10 ) ,4129-34 More Information

Liang, M-C; Ma, J; Chen, L; Kozlowski, P; Qin, W; Li, D; Goto, J; Shimamura, T; Hayes, D N; Meyerson, M; Kwiatkowski, D J; Wong, K-K (2010. ) TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity.Oncogene, , 29 (11 ) ,1588-97 More Information

Liang, M-C; Ma, J; Chen, L; Kozlowski, P; Qin, W; Li, D; Goto, J; Shimamura, T; Hayes, D N; Meyerson, M; Kwiatkowski, D J; Wong, K-K (2010. ) TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity.Oncogene, , 29 (11 ) ,1588-97 More Information

Pollizzi, Kristen; Malinowska-Kolodziej, Izabela; Doughty, Cheryl; Betz, Charles; Ma, Jian; Goto, June; Kwiatkowski, David J (2009. ) A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.Human molecular genetics, , 18 (13 ) ,2378-87 More Information

Pollizzi, Kristen; Malinowska-Kolodziej, Izabela; Doughty, Cheryl; Betz, Charles; Ma, Jian; Goto, June; Kwiatkowski, David J (2009. ) A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.Human molecular genetics, , 18 (13 ) ,2378-87 More Information

Goto, June; Tezuka, Tohru; Nakazawa, Takanobu; Sagara, Hiroshi; Yamamoto, Tadashi (2008. ) Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development.Molecular and cellular neurosciences, , 38 (2 ) ,203-12 More Information

Nakazawa, Takanobu; Komai, Shoji; Watabe, Ayako M; Kiyama, Yuji; Fukaya, Masahiro; Arima-Yoshida, Fumiko; Horai, Reiko; Sudo, Katsuko; Ebine, Kazumi; Delawary, Mina; Goto, June; Umemori, Hisashi; Tezuka, Tohru; Iwakura, Yoichiro; Watanabe, Masahiko; Yamamoto, Tadashi; Manabe, Toshiya (2006. ) NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.The EMBO journal, , 25 (12 ) ,2867-77 More Information

Goto, June; Tezuka, Tohru; Nakazawa, Takanobu; Tsukamoto, Nobuo; Nakamura, Takahisa; Ajima, Rieko; Yokoyama, Kazumasa; Ohta, Tsutomu; Ohki, Misao; Yamamoto, Tadashi (2004. ) Altered gene expression in the adult brain of fyn-deficient mice.Cellular and molecular neurobiology, , 24 (1 ) ,149-59 More Information

Taranov, Aleksandr; Bedolla, Alicia; Iwasawa, Eri; Brown, Farrah N; Baumgartner, Sarah; Fugate, Elizabeth M; Levoy, Joel; Crone, Steven A; Goto, June; Luo, Yu (2024. ) The choroid plexus maintains adult brain ventricles and subventricular zone neuroblast pool, which facilitates poststroke neurogenesis.Proceedings of the National Academy of Sciences of the United States of America, , 121 (28 ) ,e2400213121 More Information

2021 Robert McLaurin Neurosurgery Scholar

Academic - Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati  Ohio, 45229
Phone: 513-803-4582
june.goto@cchmc.org