Edwin Griff

Edwin R Griff

Associate Professor

Rieveschl Hall

731A

A&S Biological Sciences - 0006

Education

Ph.D., Purdue University West Lafayette, IN, 1979 (Biology)

BA, Brandeis University Waltham, MA, 1970 (Biology)

Research and Practice Interests

The overall goal of my research is to understand the physiological mechanisms that produce sensation. My current research investigates the sense of smell, olfaction. In olfaction, chemical odorants stimulate olfactory receptor neurons in the nose, which in turn stimulate neurons in the olfactory bulb of the brain called mitral cells. These cells respond to stimuli by producing nerve impulses (action potentials), and the primary strategy used in my lab is to record these electrical responses using electrophysiological techniques. Thus, a student joining my lab would learn to stimulate and record the responses of neurons in the olfactory system.


Important physiological questions include: how are the various cells are connected to each other in neural circuits; what is the source and temporal pattern of spontaneous activity in each neuron; how does each cell generate its response; do these responses interact in time and space, and finally, how do these responses code olfactory information? Recent anatomical and molecular data suggests that the olfactory bulb is organized into units called glomeruli where about 1000 olfactory receptor neurons, each expressing the same receptor protein, converge onto about 25 mitral cells. To what aspect of an odorant do these cells respond? Do they all respond in the same way to stimulation? Do they all exhibit the same pattern of background activity in the absence of stimulation? How do these cells interact with mitral cells in adjacent glomeruli? These are some of the specific questions that we hope to answer in the next few years.
My previous work involved the visual system, examining functional interactions between rod photoreceptors and the retinal pigment epithelium. We showed that absorption of light by rods produced a sequence of membrane potential changes mediated by a light-evoked decrease in extracellular potassium. A rapid apical membrane hyperpolarization was followed by a delayed basal membrane depolarization, and these epithelial membrane changes produced slow components of the electroretinogram, the c-wave and fast-oscillation trough. Subsequent studies have linked these electrical changes to ion transport across the epithelium, and visual manifestations of cystic fibrosis.

Research Support

Grant: #URC Investigators:Edwin R. Griff 01-2011 -12-2011 University Research Council The source of spontaneous neural activity in the olfactory bulb Role:PI 3,450 Active Type:Grant Level:Local

Grant: #R15-DC04548-01A2NCE Investigators:Griff, Edwin 07-01-2002 -06-30-2005 National Institute on Deafness and Other Communication Disor Spontaneous Activity of Mitral Cells in the Intact Rat Role:PI $147,617.00 Closed Level:Federal

Investigators:Edwin Griff, Marcus Johnson 05-2017 -09-2018 IDEA Impact Grant Students’ Engagement and Evaluations of Instructional Effectiveness by Instructor Status in Anatomy and Physiology Labs Role:PI 11,672 Denied Type:Grant

Abbreviated Publications

Peer Reviewed Publications

SFord NC and Griff ER. (2017) Steady-state centrifugal input via the lateral olfactory tract modulates spontaneous activity in the rat main olfactory bulb.  Neuroscience 348: 165–179, .

Griff, E.R. 2016. Changing Undergraduate Human Anatomy and Physiology Labs: Perspectives from a Large-Enrollment Course. Advances in Physiology Education 40:388–392.

Favela, L.H., Coey, C.A., Griff, E.R., Richardson. M.J. 2016.  Fractal analysis reveals subclasses of neurons and suggests an explanation of their spontaneous activity. Neuroscience Letters 626:54–58.

Griff, E.R. and Matter, S.F. 2013. Evaluation of an adaptive online learning system.  British Journal of Educational Technology 44:170-176.

Edwin R. Griff , Nancy K. Kleene, and Steven J. Kleene.  2012. A Selective PMCA Inhibitor Does Not Prolong the Electroolfactogram in Mouse. PLoS ONE 7(5): e37148. doi:10.1371/journal.pone.003714.

Stakic, J., Suchanek, J.M., Ziegler, G.P., and E. Griff. 2011. The source of spontaneous activity in the main olfactory bulb of the rat. PLoS ONE 6(8): 23990.doe:10.1371/journal.pone.0023990.

Griff, E. R, Matter, S. and Nica, R. 2010. Physiological evidence for two classes of mitral cells in the rat olfactory bulb.  Brain Research 1958: 81-88.

Griff, E. R. and Kane, T. 2010.  A housefly sensory-motor integration laboratory.  Advances in Physiology Education 34:106-110.

Griff, E. R., & Matter, S.F. (2008). Early identification of at-risk students using a personal response system. British Journal of Educational Technology, 39, 1124-1130.

Griff, E., Mafhouz, M., Perrut, A., & M. Chaput (2008). Comparison of identified mitral and tufted cells in freely breathing rats: I. conduction velocity and spontaneous activity. Chemical Senses, 33, 779-792.

Griff, E., Mafhouz, M., & M. Chaput (2008). Comparison of identified mitral and tufted cells in freely breathing rats: II. odor-evoked responses. Chemical Senses, 33, 793-802.

Mast, T.G., & Griff, E. R. (2007). The effects of analgesic supplements on neural activity in the main olfactory bulb of the mouse. Comparative Medicine, 57, 167-174.

Griff, E. R. (2006). How neurons work: An analogy and demonstration using a sparkler and a frying pan. American Biology Teacher, 68, 412-417.

Mast, T.G., & Griff, E. R. (2005). In vivo preparation and identification of mital cells in the main olfactory bulb of the mouse. Brain Research Protocols, 15, 105-113.

Phillips, S., Griff, E. R. (2002). Impulse conduction of olfactory receptor neuron axons. Microscopy research and technique, 58(3), 161, 167.

Griff, E. R., Greer, C. A., Margolis, F., Ennis, M., Shipley, M. T. (2000). Ultrastructural characteristics and conduction velocity of olfactory receptor neuron axons in the olfactory marker protein-null mouse. Brain research, 866(1-2), 227, 236.

El-Etri, M. M., Ennis, M., Griff, E. R., Shipley, M. T. (1999). Evidence for cholinergic regulation of basal norepinephrine release in the rat olfactory bulb. Neuroscience, 93(2), 611, 617.

Jiang, M. R., Griff, E. R., Ennis, M., Zimmer, L. A., Shipley, M. T. (1996). Activation of locus coeruleus enhances the responses of olfactory bulb mitral cells to weak olfactory nerve input. Journal of Neuroscience, 16(19), 6319, 6329.

Haugh-Scheidt, L. M., Griff, E. R., Linsenmeier, R. A. (1995). Light-Evoked Oxygen Responses in the Isolated Toad Retina. Experimental eye research, 61(1), 73, 81.

Haugh-Scheidt, L. M., Linsenmeier, R. A., Griff, E. R. (1995). Oxygen-Consumption in the Isolated Toad Retina. Experimental eye research, 61(1), 63, 72.

Griff, E. R. (1991). Potassium-Evoked Responses from the Retinal-Pigment Epithelium of the Toad Bufo-Marinus. Experimental eye research, 53(2), 219, 228.

Griff, E. R. (1990). Metabolic-Inhibitors Reversibly Alter the Basal Membrane-Potential of the Gecko Retinal-Pigment Epithelium. Experimental eye research, 50(1), 99, 107.

Griff, E. R. (1990). Response Properties of the Toad Retinal-Pigment Epithelium. Investigative ophthalmology & visual science, 31(11), 2353, 2360.

Gallemore, R. P., Griff, E. R., Steinberg, R. H. (1988). Evidence in Support of a Photoreceptoral Origin for the Light-Peak Substance. Investigative ophthalmology & visual science, 29(4), 566, 571.

Scharschmidt, B. F., Griff, E. R., Steinberg, R. H. (1988). Effect of Taurine on the Isolated Retinal-Pigment Epithelium of the Frog - Electrophysiologic Evidence for Stimulation of an Apical, Electrogenic Na+-K+ Pump. Journal of Membrane Biology, 106(1), 71, 81.

Griff, E. R., Shirao, Y., Steinberg, R. H. (1985). Ba-2+ Unmasks K+ Modulation of the Na+-K+ Pump in the Frog Retinal-Pigment Epithelium. Journal of General Physiology, 86(6), 853, 876.

Griff, E. R., Steinberg, R. H. (1984). Changes in Apical [K+] Produce Delayed Basal Membrane Responses of the Retinal-Pigment Epithelium in the Gecko. Journal of General Physiology, 83(2), 193, 211.

Griff, E. R., Pinto, L. H. (1984). Observations on Rod Coupling in the Isolated Retina of Bufo-Marinus. Vision research, 24(2), 149, 157.

Steinberg, R. H., Linsenmeier, R. A., Griff, E. R. (1983). 3 Light-Evoked Responses of the Retinal-Pigment Epithelium. Vision research, 23(11), 1315, 1323.

Griff, E. R., Steinberg, R. H. (1982). Origin of the Light Peak - Invitro Study of Gekko-Gekko. Journal of Physiology-London, 331(OCT), 637, 652.

Griff, E. R., Pinto, L. H. (1981). Interactions among Rods in the Isolated Retina of Bufo-Marinus. Journal of Physiology-London, 314(MAY), 237, 254.

Published Abstract

Favela, L.H., Coey, C.A., Griff, E.R. and M.J. Richardson. 2014. Fractal analysis of spontaneous activity in single neurons.  Society for Neuroscience.  Washington, D.C.

Neil C. Ford, Edwin R. Griff. 2012. Blocking the lateral olfactory tract in vivo alters spontaneous activity in the main olfactory bulb of the rat.  Association for Chemorecptive Sciences (AChemS)

"Blocking the lateral olfactory tract alters spontaneous activity of neurons in the main olfactory bulb of the rat in vivo" Ford NC and Griff ER. Poster presentation at the 2012 meeting of the Ohio Miami Valley Chapter of the Society for Neuroscience. Oxford, OH

Suleiman, J. H., Griff, E. R. (1993). Recovery from Detachment in the Toad Retina [Abstract]. Investigative ophthalmology & visual science, 34(4), 957, 957.

Haugh, L. M., Linsenmeier, R. A., Griff, E. R. (1992). Oxygen-Consumption of the Isolated Toad Retina during Dark and Light Adaptation [Abstract]. Investigative ophthalmology & visual science, 33(4), 838, 838.

Haugh, L. M., Griff, E. R., Linsenmeier, R. A. (1991). Light-Evoked Oxygen Responses in the Isolated Toad Retina [Abstract]. Investigative ophthalmology & visual science, 32(4), 671, 671.

Jiang, M., Griff, E.R., Zimmer, L.A., Ennis, M., & Shipley, M.T. (1993). Locus coeruleus increases perithreshold sensory-evoked excitation of mitral cells. [Abstract]. Association for Chemoreception Sciences (AchemS).

Griff, E.R., Margolis, F.L., Ennis, M, & Shipley, M.Y. (1998). Conduction velocity of olfactory receptor neurons in the OMP-null mutant mouse [Abstract]. Association for Chemoreception Sciences (AchemS).

Jiang, M., Griff, E.R., Zimmer, L.A., Ennis, M., & Shipley, M.T. (1993). LC activation increases perithreshold sensory excitation of olfactory bulb mitral cells [Abstract]. Society for Neuroscience.

Griff, E.R. & Bonasso, C.L (1990). A light peak in the toad, Bufo marinus [Abstract]. Invest Ophthalmol. Vis. Sci., Suppl., 31, 391.

Griff, E.R. & Law, N.G. (1989). Light-evoked responses from the RPE of Bufo marinus. [Abstract]. Invest. Ophthalmol. Vis. Sci., Suppl., 30, 44.

Griff, E.R. (1988). Metabolic dependence of RPE membrane potentials [Abstract]. Invest. Ophthalmol. Vis. Sci., Suppl., 39, 93.

Steinberg, R.H., Gallemore, R.P. & Griff, E.R. (1987). Origin of the light peak: contribution from the neural retina [Abstract]. Invest. Ophthalmol. Vis. Sci., Suppl., 28, 402.

Textbooks Authored

Zao, P., Stabler, T., Smith, L., Lokuta, A., and E. Griff. 2012. PhysioEx 9.0: Laboratory simulations in Physiology. Pearson Education Inc., San Francisco, CA.

Presentations

Invited Presentations

Edwin R. Griff (04-2010. )Lab simulation programs for Anatomy and Physiology- Updates and enhancements to the Physio-Ex Neurophysiology exercise .Innovations 2010, Cincinnati, OH. Level:Regional

Lecture

Edwin Griff (08-31-2013. )Research opportunities .Rieveschl 615. UC. Level:Department

Edwin Griff (01-11-2013. )Research opportunities .Rieveschl 615. UC. Level:Department

Edwin Griff Research opportunities .UC. Level:Department

Edwin Griff Research opportunities .UC. Level:Department

Edwin Griff Research opportunities .UC. Level:Department

Edwin Griff Research opportunities .UC. Level:Department

Edwin Griff Research opportunities .UC. Level:Department

Edwin Griff Research opportunities .UC. Level:Department

Service

Department of Biological Sciences (Teaching Effectiveness committee )Member Type:Departmental Service Level:Department 01-03-2010 -12-15-2010

College of Arts and Sciences (Curriculum Committee )Member Type:University/College Service Level:College 01-03-2010 -To Present

AAUP (Associates Council )Member Type:University/College Service Level:University 01-03-2010 -09-01-2012

(Undergraduate Affairs )Committee Member Type:Departmental Service Level:Department 09-2011 -To Present

(Undergraduate Research and Honors )Committee Chair Type:Departmental Service Level:Department 09-2011 -To Present

(Spring Event Planning )Committee Member Type:University/College Service Level:College 01-2012 -To Present

(Director of Undergraduate Research )Director Type:Departmental Service Level:Department 01-2011 -01-2017

(UC task force on convervion to semesters for Arts and Sciences )Member Type:University/College Service Level:College 01-01-2008 -05-01-2008

(Neuroscience Steering Committee )Type:University/College Service Level:University 2012 -To Present

(Faculty Assessor for the 2011 Undergraduate Research Poster Session )Committee Member Type:University/College Service Level:University 06-03-2011 -06-03-2011

(Undergraduate Research Committee )Committee Member Type:University/College Service Level:College 11-01-2011 -06-01-2012

(Undergraduate Studies )Committee Chair Type:Departmental Service Level:Department 08-2016 -To Present

(Undergraduate Council )Member Type:University/College Service Level:College 08-2016 -To Present

Human Anatomy & Physiology Society (HAPS) (Curriculum )Member Type:Service to Professional Associations Level:International 05-2016 -To Present

Pre-Health Advising Center (Pre-Health Advisory Board )Member Type:University/College Service Level:University 03-2016 -To Present

College of Arts and Sciences (College Grievance Review Committee )Committee Member Type:University/College Service Level:College 01-2018 -To Present

Type:University/College Service Level:University 04-16-2018 -04-16-2018

Post Graduate Training and Education

1979-1985 Retinal physiologist, Conducted research on the interactions between the neural retina and the retinal pigment epithelium. The primary technique involved electrophysiological and ion concentration measurements from the eye, University of California Medical School, ,San Francisco, CA

Courses Taught

15-BIOL-201 ANAT & PHYS I Level:Undergraduate

15-BIOL-201 ANAT & PHYS I Level:Undergraduate

15-BIOL-201 ANAT & PHYS I Level:Undergraduate

15-BIOL-201 ANAT & PHYS I

15-BIOL-201 ANAT & PHYS I Level:Undergraduate

15-BIOL-540 NEUROBIOLOGY Level:Both

15-BIOL-202 ANAT & PHYS II Level:Undergraduate

-BIOL-2001C ANAT PHYS I Level:Undergraduate

-BIOL-4095 UNDERGRAD RESEARCH Level:Undergraduate

Anatomy & Physiology I Level:Undergraduate

Neurobiology Level:Undergraduate

Vertebrate Sensory Biology Level:Graduate

Faculty Development Activities

03-20-2015 AFTL Teaching Showcase Academy of Fellows for Teaching & Learning UC Type:Conference Attendance

BAD DATE -BAD DATE Northstar Summer Institute This was a week-long intensive workshop on improving biology education, The National Academies University of Minnesota Type:Workshop

BAD DATE -BAD DATE HAPS Central Regional Meeting Talks and posters, Human Anatomy & Physiology Society (HAPS) Galen College of Nursing, Cincinnati, OH Type:Conference Attendance

BAD DATE -BAD DATE 29th Annual Conference workshops, talks, posters, Human Anatomy & Physiology Society (HAPS) University of Texas, San Antonio Type:Conference Attendance

05-24-2017 -05-28-2017 31th Annual Conference Organization: Human Anatomy & Physiology Society (HAPS) Attend update seminars, poster sessions and workshops, Human Anatomy & Physiology Society (HAPS) Salt Lake City, Utah Type:Conference Attendance

05-21-2016 -05-25-2016 30th Annual Conference Organization: Human Anatomy & Physiology Society (HAPS) Attend update seminars, poster sessions, and workshops, Human Anatomy & Physiology Society (HAPS) Atlanta GA Type:Conference Attendance

04-14-2016 -04-17-2016 2016 Annual International Conference Attend keynote speakers' presentations, poster sessions, National Association for Research in Science Teaching Baltimore MD Type:Conference Attendance

Other Information

A&S Faculty Development grant to attend the 2018 conference of the Human Anatomy & Physiology Society,

A&S Faculty Development grant to attend the 2017 Conference of the Human Anatomy & Physiology Society,