Anthony Grillo

Anthony Steven Grillo

Assoc Professor

Assistant Professor, Chemistry

Phone 5135561034
Email grilloas@ucmail.uc.edu

Professional Summary

Group Website
www.GrilloLabUC.com

Anthony Grillo joined the University of Cincinnati in the Department of Chemistry as an Assistant Professor in 2022 with research interests in understanding the molecular underpinnings of the role of mitochondrial dysfunction in disease with an emphasis on micronutrient (e.g. metals, oxygen, vitamins, etc.) metabolism.

Dr. Grillo obtained a B.S. in Biochemistry and B.S. in Chemistry from the University of Michigan in 2011. He obtained his Ph.D. in Chemistry (Organic Chemistry focus) in 2017 at the University of Illinois at Urbana-Champaign under the mentorship of Martin Burke as an NSF predoctoral fellow (NSF GRFP). His thesis centered on the discovery, development, and mechanistic understanding of small molecules that mimic protein function to restore physiology to organisms missing iron transport proteins, thereby acting as prostheses on the molecular scale. As an NRSA postdoctoral fellow and Alzheimer's Disease Research Center Trainee in Matt Kaeberlein's Lab at the University of Washington, Dr. Grillo elucidated the mechanistic role of protein kinace C in promoting neuroinflammation in mitochondrial disease mice and the influence of iron status on disease progression.

Dr. Grillo's background in biochemistry, chemical biology, and metabolic physiology make him excited to perform interdisciplinary research centered on revealing how mitochondrial dysfunction alters micronutrient metabolism (e.g. metals, oxygen, vitamins, etc.) to elicit neurodegeneration in age-related, genetic, or environmental-induced disease in multiple in vitro and in vivo models.

Education

Ph.D. Chemistry: University of Illinois at Urbana-Champaign 2017 (Organic Chemistry)

B.S. Chemistry: University of Michigan 2011

B.S. Biochemistry: University of Michigan 2011

Research and Practice Interests

The Grillo Lab's interests include:

     1) Elucidating the etiology of mitochondrial Complex I deficiencies and oxygen dyshomeostasis in neurodegeneration.
     2) Uncovering the role of transition metals in age-related diseases.
     3) Discovering novel interventions to treat mitochondrial inborn errors of metabolism.

Service

2022 OEPT Training Workshop

2022 Graduate Admissions Committee

2022 Diversity, Equity, and Inclusion Taskforce

2023 Global Research Experience in Chemistry Program

Courses Taught

2022 CHEM 8039: Transition Metals in Biochemistry, Biology, and Medicine

Contact Information

Academic - Phone: 5135561034
grilloas@ucmail.uc.edu