Christina Gross , PhD

My research aims to identify and understand pathological molecular mechanisms contributing to neurodevelopmental and neurological disorders such as autism and epilepsy. Our ultimate goal is to use this knowledge for the development of therapeutic strategies and molecular biomarkers.
link to lab home page: https://www.cincinnatichildrens.org/research/divisions/n/neurology/labs/gross

Peer Reviewed Publications

Gross, Christina; Hoffmann, Anne; Bassell, Gary J; Berry-Kravis, Elizabeth M (2015. ) Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , 12 (3 ) ,584-608 More Information

Poopal, Ashwini C; Schroeder, Lindsay M; Horn, Paul S; Bassell, Gary J; Gross, Christina (2016. ) Increased expression of the PI3K catalytic subunit p110? underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family.Molecular autism, , 7 ,3 More Information

Gross, Christina; Chang, Chia-Wei; Kelly, Seth M; Bhattacharya, Aditi; McBride, Sean M J; Danielson, Scott W; Jiang, Michael Q; Chan, Chi Bun; Ye, Keqiang; Gibson, Jay R; Klann, Eric; Jongens, Thomas A; Moberg, Kenneth H; Huber, Kimberly M; Bassell, Gary J (2015. ) Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome.Cell reports, , 11 (5 ) ,727-36 More Information

Gross, Christina; Raj, Nisha; Molinaro, Gemma; Allen, Amanda G; Whyte, Alonzo J; Gibson, Jay R; Huber, Kimberly M; Gourley, Shannon L; Bassell, Gary J (2015. ) Selective role of the catalytic PI3K subunit p110? in impaired higher order cognition in fragile X syndrome.Cell reports, , 11 (5 ) ,681-8 More Information

Sasaki, Yukio; Gross, Christina; Xing, Lei; Goshima, Yoshio; Bassell, Gary J (2014. ) Identification of axon-enriched microRNAs localized to growth cones of cortical neurons.Developmental neurobiology, , 74 (3 ) ,397-406 More Information

Gross, Christina; Bassell, Gary J (2014. ) Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders.Frontiers in molecular neuroscience, , 7 ,12 More Information

Jakkamsetti, Vikram; Tsai, Nien-Pei; Gross, Christina; Molinaro, Gemma; Collins, Katie A; Nicoletti, Ferdinando; Wang, Kuan H; Osten, Pavel; Bassell, Gary J; Gibson, Jay R; Huber, Kimberly M (2013. ) Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depression.Neuron, , 80 (1 ) ,72-9 More Information

Larimore, Jennifer; Ryder, Pearl V; Kim, Kun-Yong; Ambrose, L Alex; Chapleau, Christopher; Calfa, Gaston; Gross, Christina; Bassell, Gary J; Pozzo-Miller, Lucas; Smith, Yoland; Talbot, Konrad; Park, In-Hyun; Faundez, Victor (2013. ) MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons.PloS one, , 8 (6 ) ,e65069 More Information

Gross, Christina; Bassell, Gary J (2012. ) Excess protein synthesis in FXS patient lymphoblastoid cells can be rescued with a p110?-selective inhibitor.Molecular medicine (Cambridge, Mass.), , 18 ,336-45 More Information

Nalavadi, Vijayalaxmi C; Muddashetty, Ravi S; Gross, Christina; Bassell, Gary J (2012. ) Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 32 (8 ) ,2582-7 More Information

Gross, Christina; Berry-Kravis, Elizabeth M; Bassell, Gary J (2012. ) Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, , 37 (1 ) ,178-95 More Information

Swanger, Sharon A; Yao, Xiaodi; Gross, Christina; Bassell, Gary J (2011. ) Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model.Molecular brain, , 4 ,38 More Information

Pak, Changhui; Garshasbi, Masoud; Kahrizi, Kimia; Gross, Christina; Apponi, Luciano H; Noto, John J; Kelly, Seth M; Leung, Sara W; Tzschach, Andreas; Behjati, Farkhondeh; Abedini, Seyedeh Sedigheh; Mohseni, Marzieh; Jensen, Lars R; Hu, Hao; Huang, Brenda; Stahley, Sara N; Liu, Guanglu; Williams, Kathryn R; Burdick, Sharon; Feng, Yue; Sanyal, Subhabrata; Bassell, Gary J; Ropers, Hans-Hilger; Najmabadi, Hossein; Corbett, Anita H; Moberg, Kenneth H; Kuss, Andreas W (2011. ) Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans.Proceedings of the National Academy of Sciences of the United States of America, , 108 (30 ) ,12390-5 More Information

Muddashetty, Ravi S; Nalavadi, Vijayalaxmi C; Gross, Christina; Yao, Xiaodi; Xing, Lei; Laur, Oskar; Warren, Stephen T; Bassell, Gary J (2011. ) Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling.Molecular cell, , 42 (5 ) ,673-88 More Information

Ivanova, T N; Matthews, A; Gross, C; Mappus, R C; Gollnick, C; Swanson, A; Bassell, G J; Liu, R C (2011. ) Arc/Arg3.1 mRNA expression reveals a subcellular trace of prior sound exposure in adult primary auditory cortex.Neuroscience, , 181 ,117-26 More Information

Gross, Christina; Yao, Xiaodi; Pong, Dan L; Jeromin, Andreas; Bassell, Gary J (2011. ) Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 31 (15 ) ,5693-8 More Information

Swanger, Sharon A; Bassell, Gary J; Gross, Christina (2011. ) High-resolution fluorescence in situ hybridization to detect mRNAs in neuronal compartments in vitro and in vivo.Methods in molecular biology (Clifton, N.J.), , 714 ,103-23 More Information

Gross, Christina; Nakamoto, Mika; Yao, Xiaodi; Chan, Chi-Bun; Yim, So Y; Ye, Keqiang; Warren, Stephen T; Bassell, Gary J (2010. ) Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 30 (32 ) ,10624-38 More Information

Bassell, Gary J; Gross, Christina (2008. ) Reducing glutamate signaling pays off in fragile X.Nature medicine, , 14 (3 ) ,249-50 More Information

Muddashetty, Ravi S; Keli?, Sofija; Gross, Christina; Xu, Mei; Bassell, Gary J (2007. ) Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 27 (20 ) ,5338-48 More Information

Plath, Niels; Ohana, Ora; Dammermann, Björn; Errington, Mick L; Schmitz, Dietmar; Gross, Christina; Mao, Xiaosong; Engelsberg, Arne; Mahlke, Claudia; Welzl, Hans; Kobalz, Ursula; Stawrakakis, Anastasia; Fernandez, Esperanza; Waltereit, Robert; Bick-Sander, Anika; Therstappen, Eric; Cooke, Sam F; Blanquet, Veronique; Wurst, Wolfgang; Salmen, Benedikt; Bösl, Michael R; Lipp, Hans-Peter; Grant, Seth G N; Bliss, Tim V P; Wolfer, David P; Kuhl, Dietmar (2006. ) Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.Neuron, , 52 (3 ) ,437-44 More Information

Gross, C; Heumann, R; Erdmann, K S (2001. ) The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif. FEBS letters, , 496 (2-3 ) ,101-4

Ivanova, Tamara N; Gross, Christina; Mappus, Rudolph C; Kwon, Yong Jun; Bassell, Gary J; Liu, Robert C (2017. ) Familiarity with a vocal category biases the compartmental expression ofArc/Arg3.1in core auditory cortex.Learning & memory (Cold Spring Harbor, N.Y.), , 24 (12 ) ,612-621 More Information

Bienkowski, Rick S; Banerjee, Ayan; Rounds, J Christopher; Rha, Jennifer; Omotade, Omotola F; Gross, Christina; Morris, Kevin J; Leung, Sara W; Pak, ChangHui; Jones, Stephanie K; Santoro, Michael R; Warren, Stephen T; Zheng, James Q; Bassell, Gary J; Corbett, Anita H; Moberg, Kenneth H (2017. ) The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons.Cell reports, , 20 (6 ) ,1372-1384 More Information

Wang, Eric T; Taliaferro, J Matthew; Lee, Ji-Ann; Sudhakaran, Indulekha P; Rossoll, Wilfried; Gross, Christina; Moss, Kathryn R; Bassell, Gary J (2016. ) Dysregulation of mRNA Localization and Translation in Genetic Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 36 (45 ) ,11418-11426 More Information

Gross, Christina; Yao, Xiaodi; Engel, Tobias; Tiwari, Durgesh; Xing, Lei; Rowley, Shane; Danielson, Scott W; Thomas, Kristen T; Jimenez-Mateos, Eva M; Schroeder, Lindsay M; Pun, Raymund Y K; Danzer, Steve C; Henshall, David C; Bassell, Gary J (2016. ) MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset.Cell reports, , 17 (1 ) ,37-45 More Information

Tiwari, Durgesh; Peariso, Katrina; Gross, Christina (2018. ) MicroRNA-induced silencing in epilepsy: Opportunities and challenges for clinical application.Developmental dynamics : an official publication of the American Association of Anatomists, , 247 (1 ) ,94-110 More Information

Gross, Christina (2017. ) Defective phosphoinositide metabolism in autism.Journal of neuroscience research, , 95 (5 ) ,1161-1173 More Information

Academic - Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati  Ohio, 45229
Phone: 513-636-4222
Christina.Gross@cchmc.org