Jun-lin Guan

Jun-lin Guan

Department Chair, Professor

Vontz Center

3324

COM Cancer Biology Chair - 0521

Vontz Center for Molecular Studies
Room 3324
Cincinnati, Ohio 45267

Professional Summary

~~Dr. Jun-Lin Guan received his education at the University of Science and Technology in China (B.S. 1982) and the University of California at San Diego (Ph.D. 1987). After postdoctoral training at the Center for Cancer Research at MIT, Dr. Guan joined Cornell University faculty as an Assistant Professor in 1991. He rose through the ranks to become a full Professor in 2001 and was director of graduate studies and professor of molecular medicine at Cornell University and also a member of the Cornell Nanobiotechnology Center. In 2006, he moved to the University of Michigan Medical School as a professor of internal medicine in the division of molecular medicine and genetics and of cell and developmental biology. In 2014, he joined University of Cincinnati College of Medicine as the Francis Brunning Endowed Chair and professor of cancer biology, associate director for research of the University of Cincinnati Cancer Institute (UCCI) and co-leader of molecular and cellular basis of cancer of the Cincinnati Cancer Center (CCC).
    Dr. Guan’s research centers on the mechanisms of cell signaling in biological processes and how disruption of the normal signaling pathways leads to cancer and other diseases. He is world renowned for his work on focal adhesion kinase (FAK), an important cytoplasmic signaling enzyme that impacts a wide range of normal physiology and pathology. His pioneering studies on the induction of tyrosine phosphorylation of an 120 kDa protein (pp120) upon cell adhesion and the identification of pp120 as a novel tyrosine kinase FAK that is controlled by both cell adhesion and oncogenic transformation helped to open up a new research field on signal transduction by integrins in the early 1990’s. His laboratory has made major contributions in the discovery and characterization of other signaling molecules and pathways in the regulation of cell migration, survival and proliferation by intergrin signaling through FAK. In recent years, Dr. Guan’s group have developed sophisticated mouse models with conditional FAK knockout and mutant knockin to demonstrate critical functions of FAK signaling in tumor development, metastasis, cancer stem cells, and angiogenesis. Dr. Guan’s laboratory is also at the forefront in deciphering the role of autophagy in biological and disease processes. His work in the early 2000’s identified and characterized a key protein FIP200 (FAK-family Interacting Protein of 200 Kd) that was subsequently shown as a component of a complex essential for autophagy induction in mammalian cells. Dr. Guan’s lab was the first to demonstrate a positive role for autophagy in promoting cancer development and progression in animal models with intact immune system. His current work continues to investigate the role of autophagy in cancer stem cells, dormancy, drug resistance, relapse and metastasis as well as in neural stem cells.
    Dr. Guan received many awards and honors, including Kuo Mu-Rao Award (1982), Anna Fuller Cancer Fund fellowship (1987), SmithKline Beecham Award for Research Excellence at Cornell University (1993), the Established Investigator Award from American Heart Association (1998), and League of Research Excellence at University of Michigan Medical School (2011). He has received continuous grants from the National Institutes of Health since 1992. He has mentored a large number of graduate students and postdoctoral fellows, who have become independent investigators. Dr. Guan is the author of more than 140 scientific papers, many of which are landmark contributions to his research fields. He was editor of Signaling Through Cell Adhesion Molecules (1999) and Cell Migration: Developmental Methods and Protocols (2005). He has served on the editorial boards of several journals including the Journal of Biological Chemistry, Molecular and Cellular Pharmacology and the Journal of Breast Cancer: Targets and Therapy. He also has

Education

Bachelor's Degree, University of Science and Technology of China 1982 (Biology)

Doctoral Degree, University of California at San Diego 1987 (Biology)

Positions and Work Experience

04-19-1991 -1997 Assistant Professor, Department of Molecular Medicine, Cornell University,

1997 -2001 Associate Professor, Department of Molecular Medicine, , Cornell University,

11-19-1998 -05-19-1999 Visiting Professor, Sabbatical leave from Cornell University, Department of Bioengineering, University of California, San Diego, CA

09-20-2002 -09-20-2006 Member Nanobiotechnology Center, Cornell University,

07-20-2005 -09-20-2006 Director of Graduate Studies (Field of Pharmacology), Cornell University,

09-20-2006 -12-20-2013 Professor, Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan Medical School,

09-20-2006 -12-20-2013 Professor, Department of Cell and Developmental Biology, University of Michigan Medical School,

09-20-2006 -12-20-2013 Member, University of Michigan Comprehensive Cancer Center,

Research and Practice Interests

Tyrosine kinase signaling in the regulation of breast cancer stem cells and angiogenesis Autophagy in breast cancer, neuralstem cells and neurodegenerative diseases Discovery of new signaling molecules in cell migration, angiogenesis and metastasis.

Research Support

Grant: #R01CA211066 Investigators:Guan, Jun-lin 06-15-2017 -05-31-2022 National Cancer Institute Mechanisms of FIP200 regulation of breast cancer through its autophagy and non-autophagy functions Role:PI $364,571.00 Active Level:Federal

Grant: #mTORC1 Investigators:Guan, Jun-lin 08-01-2016 -07-31-2017 Angiosarcoma Awareness Inc. Therapeutic targeting of mTORC1 for lymphangiosarcoma using a novel mouse model Role:PI $43,200.00 Active Level:Private Non-Profit

Grant: #R03NS097887 Investigators:Guan, Jun-lin; Wang, Chenran 07-01-2016 -06-30-2018 National Institute of Neurological Disorders and Stroke Mechanisms of autophagy in TSC1-deficient neural stem cells Role:Collaborator $79,000.00 Awarded Level:Federal

Grant: #NS094144-01 Investigators:Guan, Jun-lin 09-01-2015 -08-31-2020 National Institute of Neurological Disorders and Stroke Mechanisms of Neural Stem Cells Regulation by Autophagy Role:PI $345,625.00 Awarded Level:Federal

Grant: #R01CA150926 Investigators:Guan, Jun-lin 09-11-2014 -12-31-2014 National Cancer Institute Molecular Analysis of Signal Transduction in Cancer Development and Progression Role:PI $81,887.00 Awarded Level:Federal

Grant: #3003154652 / R01 AR062030 Investigators:Guan, Jun-lin 06-01-2014 -08-31-2017 National Institute of Arthritis, Musculoskeletal and Skin Disease THE MECHANISMS OF BONE MASS REGULATION BY FIP200 Role:PI $10,188.00 Active Level:Federal

Grant: #R01 HL073394 Investigators:Guan, Jun-lin 04-01-2014 -03-31-2017 National Heart, Lung and Blood Institute Analysis of intracellular signaling in angiogenesis Role:PI $395,625.00 Active Level:Federal

Grant: #7R01CA163493-03 Investigators:Guan, Jun-lin 04-01-2014 -03-31-2017 National Cancer Institute Genetic Analysis of FAK kinase and scaffold functions in breast cancer Role:PI $319,021.00 Awarded Level:Federal

Grant: #3003077923 / R01CA125577 Investigators:Guan, Jun-lin 01-01-2014 -11-30-2018 National Cancer Institute ROLE OF CCN6 (WISP3) IN THE PROGRESSION AND METASTASIS OF BREAST CANCER. Role:PI $17,520.00 Awarded Level:Federal

Grant: #VA Billing Agreement - Brian Hunt Investigators:Guan, Jun-lin; Hunt, Brian 07-01-2017 -06-30-2019 Department of Veterans Affairs VA Contract - Brian Hunt Role:Collaborator $65,237.40 Awarded Level:Federal

Grant: #R01NS103981 Investigators:Guan, Jun-lin; Wang, Chenran 07-15-2018 -06-30-2023 National Institute of Neurological Disorders and Stroke Regulation of lipid catabolism by autophagy in neural stem cell of tuberous sclerosis complex Role:Collaborator $350,000.00 Active Level:Federal

Grant: #R01 HL073394 Investigators:Guan, Jun-lin 09-01-2018 -07-31-2022 National Heart, Lung and Blood Institute Autophagy and mTORC1 signaling in lymphatic malformation and lymphangiosarcoma Role:PI $416,946.00 Active Level:Federal

Grant: #OK St. Univ / R01AI141399 Investigators:Guan, Jun-lin 11-15-2018 -10-31-2023 National Institute of Allergy and Infectious Diseases Role of FIP200 in RIG-I-mediated innate immunity Role:PI $19,328.00 Awarded Level:Federal

Grant: #R01GM128216 Investigators:Czyzyk-Krzeska, Maria; Greis, Kenneth; Guan, Jun-lin; Meller, Jaroslaw 09-12-2019 -08-31-2023 National Institute of General Medical Sciences Mechanisms of selective autophagy Role:Collaborator $314,708.00 Awarded Level:Federal

Grant: #TUL-HSC-557767_ R01AI141399 Investigators:Guan, Jun-lin 11-01-2019 -10-31-2023 National Institute of Allergy and Infectious Diseases Role of FIP200 in RIG-I-mediated innate immunity Role:PI $20,266.85 Awarded Level:Federal

Grant: #R01NS094144 Investigators:Guan, Jun-lin; Wang, Chenran 09-01-2020 -06-30-2025 National Institute of Neurological Disorders and Stroke Regulation of neural stem cells and neurogenesis by autophagy genes Role:PI $396,034.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Ogawa, Michinaga; Matsuda, Ryuta; Takada, Naoki; Tomokiyo, Mikado; Yamamoto, Shouji; Shizukusihi, Sayaka; Yamaji, Toshiyuki; Yoshikawa, Yuko; Yoshida, Mitsutaka; Tanida, Isei; Koike, Masato; Murai, Miyo; Morita, Hidetoshi; Takeyama, Haruko; Ryo, Akihide; Guan, Jun-Lin; Yamamoto, Masahiro; Inoue, Jun-Ichiro; Yanagawa, Toru; Fukuda, Mitsunori; Kawabe, Hiroshi; Ohnishi, Makoto (2018. )Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1 mediated K63-linked ubiquitination.Cellular microbiology, ,e12846

Nwadike, Chinwendu; Williamson, Leon E; Gallagher, Laura E; Guan, Jun-Lin; Chan, Edmond Y W (2018. )AMPK inhibits ULK1-dependent autophagosome formation and lysosomal acidification via distinct mechanisms.Molecular and cellular biology, ,

Huang, Huilin; Weng, Hengyou; Sun, Wenju; Qin, Xi; Shi, Hailing; Wu, Huizhe; Zhao, Boxuan Simen; Mesquita, Ana; Liu, Chang; Yuan, Celvie L; Hu, Yueh-Chiang; Hüttelmaier, Stefan; Skibbe, Jennifer R; Su, Rui; Deng, Xiaolan; Dong, Lei; Sun, Miao; Li, Chenying; Nachtergaele, Sigrid; Wang, Yungui; Hu, Chao; Ferchen, Kyle; Greis, Kenneth D; Jiang, Xi; Wei, Minjie; Qu, Lianghu; Guan, Jun-Lin; He, Chuan; Yang, Jianhua; Chen, Jianjun (2018. )Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.Nature cell biology, ,20 (3 ),285-295

Thiagarajan, Praveena S; Sinyuk, Maksim; Turaga, Soumya M; Mulkearns-Hubert, Erin E; Hale, James S; Rao, Vinay; Demelash, Abeba; Saygin, Caner; China, Arnab; Alban, Tyler J; Hitomi, Masahiro; Torre-Healy, Luke A; Alvarado, Alvaro G; Jarrar, Awad; Wiechert, Andrew; Adorno-Cruz, Valery; Fox, Paul L; Calhoun, Benjamin C; Guan, Jun-Lin; Liu, Huiping; Reizes, Ofer; Lathia, Justin D (2018. )Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase.Nature communications, ,9 (1 ),578

Sun, Shaogang; Wu, Hsin-Jung; Guan, Jun-Lin (2018. )Nuclear FAK and its kinase activity regulate VEGFR2 transcription in angiogenesis of adult mice.Scientific reports, ,8 (1 ),2550

Choi, Han Kyoung; Yuan, Hebao; Fang, Fang; Wei, Xiaoxi; Liu, Lu; Li, Qing; Guan, Jun-Lin; Liu, Fei (2018. )Tsc1 regulates the balance between osteoblast and adipocyte differentiation through autophagy/Notch1/β-catenin cascade.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, ,

Yeo, Syn Kok; Paul, Ritama; Haas, Michael; Wang, Chenran; Guan, Jun-Lin (2018. )Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer.Autophagy, ,

Martin, E E; Huang, W; Anwar, T; Arellano-Garcia, C; Burman, B; Guan, J-L; Gonzalez, M E; Kleer, C G (2017. )MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas.Oncogene, ,36 (16 ),2275-2285

Wang, Chenran; Yeo, Syn; Haas, Michael A; Guan, Jun-Lin (2017. )Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia.The Journal of cell biology, ,216 (8 ),2581-2596

He, Yun; Sun, Xiumei; Wang, Li; Mishina, Yuji; Guan, Jun-Lin; Liu, Fei (2017. )Male germline recombination of a conditional allele by the widely used Dermo1-cre (Twist2-cre) transgene.Genesis (New York, N.Y. : 2000), ,

Wacker, Rahel; Eickel, Nina; Schmuckli-Maurer, Jacqueline; Annoura, Takeshi; Niklaus, Livia; Khan, Shahid M; Guan, Jun-Lin; Heussler, Volker T (2017. )LC3-association with the parasitophorous vacuole membrane of Plasmodium berghei liver stages follows a noncanonical autophagy pathway.Cellular microbiology, ,

Chen, Xiaoyi; Clark, Jason; Wunderlich, Mark; Fan, Cuiqing; Davis, Ashley; Chen, Song; Guan, Jun-Lin; Mulloy, James C; Kumar, Ashish; Zheng, Yi (2017. )Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.Autophagy, ,13 (5 ),955-966

Ruiz-Torres, Sasha J; Benight, Nancy M; Karns, Rebekah A; Lower, Elyse E; Guan, Jun-Lin; Waltz, Susan E (2017. )HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical β-catenin signaling.Oncotarget, ,8 (35 ),58918-58933

Xia, Houjun; Wang, Wei; Crespo, Joel; Kryczek, Ilona; Li, Wei; Wei, Shuang; Bian, Zhaoqun; Maj, Tomasz; He, Mingxiao; Liu, Rebecca J; He, Youwen; Rattan, Ramandeep; Munkarah, Adnan; Guan, Jun-Lin; Zou, Weiping (2017. )Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity.Science immunology, ,2 (17 ),

Wang, Bo; Iyengar, Rekha; Li-Harms, Xiujie; Joo, Joung Hyuck; Wright, Christopher; Lavado, Alfonso; Horner, Linda; Yang, Mao; Guan, Jun-Lin; Frase, Sharon; Green, Douglas R; Cao, Xinwei; Kundu, Mondira (2017. )The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.Autophagy, ,1-16

Yeo, Syn Kok; Guan, Jun-Lin (2017. )Breast Cancer: Multiple Subtypes within a Tumor?.Trends in cancer, ,3 (11 ),753-760

Park, Sunmin; Buck, Michael D; Desai, Chandni; Zhang, Xin; Loginicheva, Ekaterina; Martinez, Jennifer; Freeman, Michael L; Saitoh, Tatsuya; Akira, Shizuo; Guan, Jun-Lin; He, You-Wen; Blackman, Marcia A; Handley, Scott A; Levine, Beth; Green, Douglas R; Reese, Tiffany A; Artyomov, Maxim N; Virgin, Herbert W (2016. )Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.Cell host & microbe, ,19 (1 ),91-101

Sun, Shaogang; Guan, Jun-Lin (2016. )Modeling lymphangiosarcoma in mice.Cell cycle (Georgetown, Tex.), ,0

Chen, Song; Wang, Chenran; Yeo, Syn; Liang, Chun-Chi; Okamoto, Takako; Sun, Shaogang; Wen, Jian; Guan, Jun-Lin (2016. )Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model.Genes & development, ,30 (7 ),856-69

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin (2016. )Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.The Journal of cell biology, ,212 (5 ),545-60

Sun, Chunhui; Yuan, Hebao; Wang, Li; Wei, Xiaoxi; Williams, Linford; Krebsbach, Paul H; Guan, Jun-Lin; Liu, Fei (2016. )FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation By Enhancing Wnt Signaling.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, ,

Wagener, Brant M; Hu, Meng; Zheng, Anni; Zhao, Xueke; Che, Pulin; Brandon, Angela; Anjum, Naseem; Snapper, Scott; Creighton, Judy; Guan, Jun-Lin; Han, Qimei; Cai, Guo-Qiang; Han, Xiaosi; Pittet, Jean-Francois; Ding, Qiang (2016. )Neuronal Wiskott-Aldrich syndrome protein regulates TGF-β1-mediated lung vascular permeability.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ,30 (7 ),2557-69

Yeo, Syn Kok; Wen, Jian; Chen, Song; Guan, Jun-Lin (2016. )Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfβ/Smad Signaling.Cancer research, ,76 (11 ),3397-410

Yeo, Syn Kok; Guan, Jun-Lin (2016. )Hierarchical heterogeneity in mammary tumors and its regulation by autophagy.Autophagy, ,12 (10 ),1960-1961

Santeford, Andrea; Wiley, Luke A; Park, Sunmin; Bamba, Sonya; Nakamura, Rei; Gdoura, Abdelaziz; Ferguson, Thomas A; Rao, P Kumar; Guan, Jun-Lin; Saitoh, Tatsuya; Akira, Shizuo; Xavier, Ramnik; Virgin, Herbert W; Apte, Rajendra S (2016. )Impaired autophagy in macrophages promotes inflammatory eye disease.Autophagy, ,12 (10 ),1876-1885

Wen, Jian; Yeo, Syn; Wang, Chenran; Chen, Song; Sun, Shaogang; Haas, Michael A; Tu, Wei; Jin, Feng; Guan, Jun-Lin (2015. )Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis.Breast cancer research and treatment, ,149 (3 ),619-29

Fang, Fang; Sun, Shaogang; Wang, Li; Guan, Jun-Lin; Giovannini, Marco; Zhu, Yuan; Liu, Fei (2015. )Neural Crest-Specific TSC1 Deletion in Mice Leads to Sclerotic Craniofacial Bone Lesion.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, ,30 (7 ),1195-205

Martinez, Jennifer; Malireddi, R K Subbarao; Lu, Qun; Cunha, Larissa Dias; Pelletier, Stephane; Gingras, Sebastien; Orchard, Robert; Guan, Jun-Lin; Tan, Haiyan; Peng, Junmin; Kanneganti, Thirumala-Devi; Virgin, Herbert W; Green, Douglas R (2015. )Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins.Nature cell biology, ,17 (7 ),893-906

Yao, Jingyu; Jia, Lin; Khan, Naheed; Lin, Chengmao; Mitter, Sayak K; Boulton, Michael E; Dunaief, Joshua L; Klionsky, Daniel J; Guan, Jun-Lin; Thompson, Debra A; Zacks, David N (2015. )Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.Autophagy, ,11 (6 ),939-53

Wei, Huijun; Guan, Jun-Lin (2015. )Blocking tumor growth by targeting autophagy and SQSTM1 in vivo.Autophagy, ,11 (5 ),854-5

Tai, Yu-Ling; Chu, Pei-Yu; Lai, I-Rue; Wang, Ming-Yang; Tseng, Hui-Yuan; Guan, Jun-Lin; Liou, Jun-Yang; Shen, Tang-Long (2015. )An EGFR/Src-dependent beta-4 integrin/FAK complex contributes to malignancy of breast cancer.Scientific reports, ,5 ,16408

Sun, Shaogang; Chen, Song; Liu, Fei; Wu, Haige; McHugh, Jonathan; Bergin, Ingrid L; Gupta, Anita; Adams, Denise; Guan, Jun-Lin (2015. )Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling.Cancer cell, ,28 (6 ),758-72

Kim, Edward; Wang, Yuan; Kim, Sun-Jung; Bornhorst, Miriam; Jecrois, Emmanuelle S; Anthony, Todd E; Wang, Chenran; Li, Yi E; Guan, Jun-Lin; Murphy, Geoffrey G; Zhu, Yuan (2014. )Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1.eLife, ,3 ,

Qu, Hong; Tu, Yizeng; Guan, Jun-Lin; Xiao, Guozhi; Wu, Chuanyue (2014. )Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit.The Journal of biological chemistry, ,289 (45 ),31001-13

Wei, Huijun; Wang, Chenran; Croce, Carlo M; Guan, Jun-Lin (2014. )p62/SQSTM1 synergizes with autophagy for tumor growth in vivo.Genes & development, ,28 (11 ),1204-16

Chen, Yongqiang; Wei, Huijun; Liu, Fei; Guan, Jun-Lin (2014. )Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling.The Journal of biological chemistry, ,289 (2 ),1164-73

Seong, Jihye; Tajik, Arash; Sun, Jie; Guan, Jun-Lin; Humphries, Martin J; Craig, Susan E; Shekaran, Asha; García, Andrés J; Lu, Shaoying; Lin, Michael Z; Wang, Ning; Wang, Yingxiao (2013. )Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins.Proceedings of the National Academy of Sciences of the United States of America, ,110 (48 ),19372-7

Hsieh, Yu-Hua; van der Heyde, Henri; Oh, Eok-Soo; Guan, Jun-Lin; Chang, Pi-Ling (2013. )Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: An Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axis.Molecular carcinogenesis, ,54 (5 ),379-92

Jin, Yixin; Liu, Yang; Lin, Qiong; Li, Jieli; Druso, Joseph E; Antonyak, Marc A; Meininger, Cynthia J; Zhang, Shenyuan L; Dostal, David E; Guan, Jun-Lin; Cerione, Richard A; Peng, Xu (2013. )Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis.Molecular and cellular biology, ,33 (21 ),4181-97

Fujita, Naonobu; Morita, Eiji; Itoh, Takashi; Tanaka, Atsushi; Nakaoka, Megumi; Osada, Yuki; Umemoto, Tetsuo; Saitoh, Tatsuya; Nakatogawa, Hitoshi; Kobayashi, Shouhei; Haraguchi, Tokuko; Guan, Jun-Lin; Iwai, Kazuhiro; Tokunaga, Fuminori; Saito, Kazunobu; Ishibashi, Koutaro; Akira, Shizuo; Fukuda, Mitsunori; Noda, Takeshi; Yoshimori, Tamotsu (2013. )Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin.The Journal of cell biology, ,203 (1 ),115-28

Peng, Xu; Lin, Qiong; Liu, Yang; Jin, Yixin; Druso, Joseph E; Antonyak, Marc A; Guan, Jun-Lin; Cerione, Richard A (2013. )Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice.Protein & cell, ,4 (3 ),231-42

Monastyrska, Iryna; Ulasli, Mustafa; Rottier, Peter J M; Guan, Jun-Lin; Reggiori, Fulvio; de Haan, Cornelis A M (2013. )An autophagy-independent role for LC3 in equine arteritis virus replication.Autophagy, ,9 (2 ),164-74

Patel, Khushbu K; Miyoshi, Hiroyuki; Beatty, Wandy L; Head, Richard D; Malvin, Nicole P; Cadwell, Ken; Guan, Jun-Lin; Saitoh, Tatsuya; Akira, Shizuo; Seglen, Per O; Dinauer, Mary C; Virgin, Herbert W; Stappenbeck, Thaddeus S (2013. )Autophagy proteins control goblet cell function by potentiating reactive oxygen species production.The EMBO journal, ,32 (24 ),3130-44

Schmidt, Tracy Thennes; Tauseef, Mohammad; Yue, Lili; Bonini, Marcelo G; Gothert, Joachim; Shen, Tang-Long; Guan, Jun-Lin; Predescu, Sanda; Sadikot, Ruxana; Mehta, Dolly (2013. )Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities.American journal of physiology. Lung cellular and molecular physiology, ,305 (4 ),L291-300

Chen, Song; Guan, Jun-Lin (2013. )Tumor-promoting and -suppressive roles of autophagy in the same mouse model of BrafV600E-driven lung cancer.Cancer discovery, ,3 (11 ),1225-7

Liu, Fei; Fang, Fang; Yuan, Hebao; Yang, Dongye; Chen, Yongqiang; Williams, Linford; Goldstein, Steven A; Krebsbach, Paul H; Guan, Jun-Lin (2013. )Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, ,28 (11 ),2414-30

Ma, Di; Molusky, Matthew M; Song, Jianrui; Hu, Chun-Rui; Fang, Fang; Rui, Crystal; Mathew, Anna V; Pennathur, Subramaniam; Liu, Fei; Cheng, Ji-Xin; Guan, Jun-Lin; Lin, Jiandie D (2013. )Autophagy deficiency by hepatic FIP200 deletion uncouples steatosis from liver injury in NAFLD.Molecular endocrinology (Baltimore, Md.), ,27 (10 ),1643-54

Luo, Ming; Zhao, Xiaofeng; Chen, Song; Liu, Suling; Wicha, Max S; Guan, Jun-Lin (2013. )Distinct FAK activities determine progenitor and mammary stem cell characteristics.Cancer research, ,73 (17 ),5591-602

Kim, Myungjin; Park, Hae Li; Park, Hwan-Woo; Ro, Seung-Hyun; Nam, Samuel G; Reed, John M; Guan, Jun-Lin; Lee, Jun Hee (2013. )Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging.Autophagy, ,9 (8 ),1201-13

Guan, Jun-Lin; Simon, Anna Katharina; Prescott, Mark; Menendez, Javier A; Liu, Fei; Wang, Fen; Wang, Chenran; Wolvetang, Ernst; Vazquez-Martin, Alejandro; Zhang, Jue (2013. )Autophagy in stem cells.Autophagy, ,9 (6 ),830-49

Wang, Chenran; Liang, Chun-Chi; Bian, Z Christine; Zhu, Yuan; Guan, Jun-Lin (2013. )FIP200 is required for maintenance and differentiation of postnatal neural stem cells.Nature neuroscience, ,16 (5 ),532-42

Ritt, Michael; Guan, Jun Lin; Sivaramakrishnan, Sivaraj (2013. )Visualizing and manipulating focal adhesion kinase regulation in live cells.The Journal of biological chemistry, ,288 (13 ),8875-86

Fan, Huaping; Zhao, Xiaofeng; Sun, Shaogang; Luo, Ming; Guan, Jun-Lin (2013. )Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo.The Journal of biological chemistry, ,288 (5 ),3322-33

Wei, Huijun; Guan, Jun-Lin (2012. )Pro-tumorigenic function of autophagy in mammary oncogenesis.Autophagy, ,8 (1 ),129-31

Cai, Guo-Qiang; Chou, Chu-Fang; Hu, Meng; Zheng, Anni; Reichardt, Louis F; Guan, Jun-Lin; Fang, Haotian; Luckhardt, Tracy R; Zhou, Yong; Thannickal, Victor J; Ding, Qiang (2012. )Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of ?-smooth muscle actin filaments during myofibroblast differentiation.American journal of physiology. Lung cellular and molecular physiology, ,303 (8 ),L692-702

Chen, Xiao Lei; Nam, Ju-Ock; Jean, Christine; Lawson, Christine; Walsh, Colin T; Goka, Erik; Lim, Ssang-Taek; Tomar, Alok; Tancioni, Isabelle; Uryu, Sean; Guan, Jun-Lin; Acevedo, Lisette M; Weis, Sara M; Cheresh, David A; Schlaepfer, David D (2012. )VEGF-induced vascular permeability is mediated by FAK.Developmental cell, ,22 (1 ),146-57

Chen, Xi; Li, Min; Chen, Daohong; Gao, Wentao; Guan, Jun-Lin; Komatsu, Massaki; Yin, Xiao-Ming (2012. )Autophagy induced by calcium phosphate precipitates involves endoplasmic reticulum membranes in autophagosome biogenesis.PloS one, ,7 (12 ),e52347

Petridou, Nicoletta I; Stylianou, Panayiota; Christodoulou, Neophytos; Rhoads, Daniel; Guan, Jun-Lin; Skourides, Paris A (2012. )Activation of endogenous FAK via expression of its amino terminal domain in Xenopus embryos.PloS one, ,7 (8 ),e42577

Kageyama, Shun; Omori, Hiroko; Saitoh, Tatsuya; Sone, Takefumi; Guan, Jun-Lin; Akira, Shizuo; Imamoto, Fumio; Noda, Takeshi; Yoshimori, Tamotsu (2011. )The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella.Molecular biology of the cell, ,22 (13 ),2290-300

Peng, Xu; Guan, Jun-Lin (2011. )Focal adhesion kinase: from in vitro studies to functional analyses in vivo. Current protein & peptide science, ,12 (1 ),52-67

Wang, Dongyan; Olman, Mitchell A; Stewart, Jerry; Tipps, Russell; Huang, Ping; Sanders, Paul W; Toline, Eric; Prayson, Richard A; Lee, Jeongwu; Weil, Robert J; Palmer, Cheryl A; Gillespie, G Yancey; Liu, Wei Michael; Pieper, Russell O; Guan, Jun-Lin; Gladson, Candece L (2011. )Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity.PloS one, ,6 (5 ),e19629

Li, Xiao-Yan; Zhou, Xiaoming; Rowe, R Grant; Hu, Yuexian; Schlaepfer, David D; Ili?, Dusko; Dressler, Gregory; Park, Ann; Guan, Jun-Lin; Weiss, Stephen J (2011. )Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells.The Journal of cell biology, ,195 (5 ),729-38

Bae, Heekyong; Guan, Jun-Lin (2011. )Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents.Molecular cancer research : MCR, ,9 (9 ),1232-41

Zhao, Xiaofeng; Guan, Jun-Lin (2011. )Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis.Advanced drug delivery reviews, ,63 (8 ),610-5

Wei, Huijun; Wei, Shuang; Gan, Boyi; Peng, Xu; Zou, Weiping; Guan, Jun-Lin (2011. )Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis.Genes & development, ,25 (14 ),1510-27

Fan, Huaping; Guan, Jun-Lin (2011. )Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity.The Journal of biological chemistry, ,286 (21 ),18573-82

Liu, Fei; Guan, Jun-Lin (2011. )FIP200, an essential component of mammalian autophagy is indispensible for fetal hematopoiesis. Autophagy, ,7 (2 ),229-30

Seong, Jihye; Ouyang, Mingxing; Kim, Taejin; Sun, Jie; Wen, Po-Chao; Lu, Shaoying; Zhuo, Yue; Llewellyn, Nicholas M; Schlaepfer, David D; Guan, Jun-Lin; Chien, Shu; Wang, Yingxiao (2011. )Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer.Nature communications, ,2 ,406

Liu, Fei; Lee, Jae Y; Wei, Huijun; Tanabe, Osamu; Engel, James D; Morrison, Sean J; Guan, Jun-Lin (2010. )FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells.Blood, ,116 (23 ),4806-14

Wang, Chenran; Yoo, Youngdong; Fan, Huaping; Kim, Eunjung; Guan, Kun-Liang; Guan, Jun-Lin (2010. )Regulation of Integrin ? 1 recycling to lipid rafts by Rab1a to promote cell migration.The Journal of biological chemistry, ,285 (38 ),29398-405

Zhao, Xiaofeng; Peng, Xu; Sun, Shaogang; Park, Ann Y J; Guan, Jun-Lin (2010. )Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development.The Journal of cell biology, ,189 (6 ),955-65

Guan, Jun-Lin (2010. )Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer.IUBMB life, ,62 (4 ),268-76

Luo, Ming; Guan, Jun-Lin (2010. )Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis.Cancer letters, ,289 (2 ),127-39

Ginestier, Christophe; Liu, Suling; Diebel, Mark E; Korkaya, Hasan; Luo, Ming; Brown, Marty; Wicinski, Julien; Cabaud, Olivier; Charafe-Jauffret, Emmanuelle; Birnbaum, Daniel; Guan, Jun-Lin; Dontu, Gabriela; Wicha, Max S (2010. )CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts.The Journal of clinical investigation, ,120 (2 ),485-97

Liang, Chun-Chi; Wang, Chenran; Peng, Xu; Gan, Boyi; Guan, Jun-Lin (2010. )Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration.The Journal of biological chemistry, ,285 (5 ),3499-509

Yoo, Y; Ho, H J; Wang, C; Guan, J-L (2010. )Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin-proteasome pathway.Oncogene, ,29 (2 ),263-72

Ma, Hong; Togawa, Akashi; Soda, Keita; Zhang, Junhui; Lee, Sik; Ma, Ming; Yu, Zhiheng; Ardito, Thomas; Czyzyk, Jan; Diggs, Lonnette; Joly, Dominique; Hatakeyama, Shinji; Kawahara, Eiji; Holzman, Lawrence; Guan, Jun Lin; Ishibe, Shuta (2010. )Inhibition of podocyte FAK protects against proteinuria and foot process effacement.Journal of the American Society of Nephrology : JASN, ,21 (7 ),1145-56

Chu, Pei-Yu; Huang, Ling-Ya; Hsu, Chun-Hua; Liang, Chun-Chi; Guan, Jun-Lin; Hung, Ting-Hsuan; Shen, Tang-Long (2009. )Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis.The Journal of biological chemistry, ,284 (30 ),20215-26

Zhao, Jihe; Guan, Jun-Lin (2009. )Signal transduction by focal adhesion kinase in cancer.Cancer metastasis reviews, ,28 (1-2 ),35-49

Hosokawa, Nao; Hara, Taichi; Kaizuka, Takeshi; Kishi, Chieko; Takamura, Akito; Miura, Yutaka; Iemura, Shun-ichiro; Natsume, Tohru; Takehana, Kenji; Yamada, Naoyuki; Guan, Jun-Lin; Oshiro, Noriko; Mizushima, Noboru (2009. )Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.Molecular biology of the cell, ,20 (7 ),1981-91

Park, Ann Y J; Shen, Tang-Long; Chien, Shu; Guan, Jun-Lin (2009. )Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis.The Journal of biological chemistry, ,284 (14 ),9418-25

Wei, Huijun; Gan, Boyi; Wu, Xiaoyang; Guan, Jun-Lin (2009. )Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models.The Journal of biological chemistry, ,284 (9 ),6004-13

Luo, Ming; Fan, Huaping; Nagy, Tamas; Wei, Huijun; Wang, Chenran; Liu, Suling; Wicha, Max S; Guan, Jun-Lin (2009. )Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.Cancer research, ,69 (2 ),466-74

Xie, Jianjun; Allen, Krystal H; Marguet, Amelia; Berghorn, Kathie A; Bliss, Stuart P; Navratil, Amy M; Guan, Jun Lin; Roberson, Mark S (2008. )Analysis of the calcium-dependent regulation of proline-rich tyrosine kinase 2 by gonadotropin-releasing hormone.Molecular endocrinology (Baltimore, Md.), ,22 (10 ),2322-35

Bechara, Ahmad; Nawabi, Homaira; Moret, Frédéric; Yaron, Avraham; Weaver, Eli; Bozon, Muriel; Abouzid, Karima; Guan, Jun-Lin; Tessier-Lavigne, Marc; Lemmon, Vance; Castellani, Valérie (2008. )FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse.The EMBO journal, ,27 (11 ),1549-62

Peng, Xu; Wu, Xiaoyang; Druso, Joseph E; Wei, Huijun; Park, Ann Yong-Jin; Kraus, Marc S; Alcaraz, Ana; Chen, Ju; Chien, Shu; Cerione, Richard A; Guan, Jun-Lin (2008. )Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice.Proceedings of the National Academy of Sciences of the United States of America, ,105 (18 ),6638-43

Hara, Taichi; Takamura, Akito; Kishi, Chieko; Iemura, Shun-Ichiro; Natsume, Tohru; Guan, Jun-Lin; Mizushima, Noboru (2008. )FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells.The Journal of cell biology, ,181 (3 ),497-510

Gan, Boyi; Guan, Jun-Lin (2008. )FIP200, a key signaling node to coordinately regulate various cellular processes.Cellular signalling, ,20 (5 ),787-94

Weis, Sara M; Lim, Ssang-Taek; Lutu-Fuga, Kimberly M; Barnes, Leo A; Chen, Xiao Lei; Göthert, Joachim R; Shen, Tang-Long; Guan, Jun-Lin; Schlaepfer, David D; Cheresh, David A (2008. )Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.The Journal of cell biology, ,181 (1 ),43-50

Martin, Nadine; Schwamborn, Klaus; Urlaub, Henning; Gan, Boyi; Guan, Jun-Lin; Dejean, Anne (2008. )Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity.Molecular and cellular biology, ,28 (8 ),2771-81

Rhoads, Daniel S; Guan, Jun-Lin (2007. )Analysis of directional cell migration on defined FN gradients: role of intracellular signaling molecules.Experimental cell research, ,313 (18 ),3859-67

Nagy, Tamas; Wei, Huijun; Shen, Tang-Long; Peng, Xu; Liang, Chun-Chi; Gan, Boyi; Guan, Jun-Lin (2007. )Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland.The Journal of biological chemistry, ,282 (43 ),31766-76

Yoo, Youngdong; Wu, Xiaoyang; Guan, Jun-Lin (2007. )A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription.The Journal of biological chemistry, ,282 (10 ),7616-23

Liang, Chun-Chi; Park, Ann Y; Guan, Jun-Lin (2007. )In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.Nature protocols, ,2 (2 ),329-33

Gan, Boyi; Yoo, Youngdong; Guan, Jun-Lin (2006. )Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth.The Journal of biological chemistry, ,281 (49 ),37321-9

Gan, Boyi; Peng, Xu; Nagy, Tamas; Alcaraz, Ana; Gu, Hua; Guan, Jun-Lin (2006. )Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways.The Journal of cell biology, ,175 (1 ),121-33

Feng, Qiyu; Baird, Dan; Peng, Xu; Wang, Jianbin; Ly, Thi; Guan, Jun-Lin; Cerione, Richard A (2006. )Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth.Nature cell biology, ,8 (9 ),945-56

Wu, Xiaoyang; Yoo, Youngdong; Okuhama, Nataly N; Tucker, Philip W; Liu, Gang; Guan, Jun-Lin (2006. )Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners.Nature cell biology, ,8 (7 ),756-63

Wei, Huijun; Wang, Xianhui; Gan, Boyi; Urvalek, Alison M; Melkoumian, Zara K; Guan, Jun-Lin; Zhao, Jihe (2006. )Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation.The Journal of biological chemistry, ,281 (24 ),16664-71

Yoo, Youngdong; Wu, Xiaoyang; Egile, Coumaran; Li, Rong; Guan, Jun-Lin (2006. )Interaction of N-WASP with hnRNPK and its role in filopodia formation and cell spreading.The Journal of biological chemistry, ,281 (22 ),15352-60

Peng, Xu; Kraus, Marc S; Wei, Huijun; Shen, Tang-Long; Pariaut, Romain; Alcaraz, Ana; Ji, Guangju; Cheng, Lihong; Yang, Qinglin; Kotlikoff, Michael I; Chen, Ju; Chien, Kenneth; Gu, Hua; Guan, Jun-Lin (2006. )Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice.The Journal of clinical investigation, ,116 (1 ),217-27

Cohen, Lee Ann; Guan, Jun-Lin (2005. )Mechanisms of focal adhesion kinase regulation. Current cancer drug targets, ,5 (8 ),629-43

Pongchairerk, Urai; Guan, Jun-Lin; Leardkamolkarn, Vijittra (2005. )Focal adhesion kinase and Src phosphorylations in HGF-induced proliferation and invasion of human cholangiocarcinoma cell line, HuCCA-1. World journal of gastroenterology : WJG, ,11 (37 ),5845-52

Melkoumian, Zara K; Peng, Xu; Gan, Boyi; Wu, Xiaoyang; Guan, Jun-Lin (2005. )Mechanism of cell cycle regulation by FIP200 in human breast cancer cells.Cancer research, ,65 (15 ),6676-84

Wu, Xiaoyang; Gan, Boyi; Yoo, Youngdong; Guan, Jun-Lin (2005. )FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation.Developmental cell, ,9 (2 ),185-96

Gan, Boyi; Melkoumian, Zara K; Wu, Xiaoyang; Guan, Kun-Liang; Guan, Jun-Lin (2005. )Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control.The Journal of cell biology, ,170 (3 ),379-89

Shen, Tang-Long; Park, Ann Y-J; Alcaraz, Ana; Peng, Xu; Jang, Ihnkyung; Koni, Pandelakis; Flavell, Richard A; Gu, Hua; Guan, Jun-Lin (2005. )Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis.The Journal of cell biology, ,169 (6 ),941-52

Moon, James J; Matsumoto, Melissa; Patel, Shyam; Lee, Luke; Guan, Jun-Lin; Li, Song (2005. )Role of cell surface heparan sulfate proteoglycans in endothelial cell migration and mechanotransduction.Journal of cellular physiology, ,203 (1 ),166-76

Cohen, Lee Ann; Guan, Jun-Lin (2005. )Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation.The Journal of biological chemistry, ,280 (9 ),8197-207

Ding, Qiang; Grammer, J Robert; Nelson, Mark A; Guan, Jun-Lin; Stewart, Jerry E; Gladson, Candece L (2005. )p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain.The Journal of biological chemistry, ,280 (8 ),6802-15

Miao, Hui; Strebhardt, Klaus; Pasquale, Elena B; Shen, Tang-Long; Guan, Jun-Lin; Wang, Bingcheng (2005. )Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases.The Journal of biological chemistry, ,280 (2 ),923-32

Li, Song; Guan, Jun-Lin; Chien, Shu (2005. )Biochemistry and biomechanics of cell motility.Annual review of biomedical engineering, ,7 ,105-50

Rodriguez, Luis G; Guan, Jun-Lin (2005. )14-3-3 regulation of cell spreading and migration requires a functional amphipathic groove.Journal of cellular physiology, ,202 (1 ),285-94

Rhoads, Daniel S; Nadkarni, Sharvari M; Song, Loling; Voeltz, Camilla; Bodenschatz, Eberhard; Guan, Jun-Lin (2005. )Using microfluidic channel networks to generate gradients for studying cell migration. Methods in molecular biology (Clifton, N.J.), ,294 ,347-57

Rodriguez, Luis G; Wu, Xiaoyang; Guan, Jun-Lin (2005. )Wound-healing assay. Methods in molecular biology (Clifton, N.J.), ,294 ,23-9

Peng, Xu; Ueda, Hiroki; Zhou, Hongming; Stokol, Tracy; Shen, Tang-Long; Alcaraz, Ana; Nagy, Tamas; Vassalli, Jean-Dominique; Guan, Jun-Lin (2004. )Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice.Cardiovascular research, ,64 (3 ),421-30

Wu, Xiaoyang; Suetsugu, Shiro; Cooper, Lee Ann; Takenawa, Tadaomi; Guan, Jun-Lin (2004. )Focal adhesion kinase regulation of N-WASP subcellular localization and function.The Journal of biological chemistry, ,279 (10 ),9565-76

Guan, Jun-Lin (2004. )Cell biology. Integrins, rafts, Rac, and Rho.Science (New York, N.Y.), ,303 (5659 ),773-4

Shen, Tang-Long; Guan, Jun-Lin (2004. )Grb7 in intracellular signaling and its role in cell regulation. Frontiers in bioscience : a journal and virtual library, ,9 ,192-200

Li, Weiquan; Lee, Jeeyong; Vikis, Haris G; Lee, Seung-Hee; Liu, Guofa; Aurandt, Jennifer; Shen, Tang-Long; Fearon, Eric R; Guan, Jun-Lin; Han, Min; Rao, Yi; Hong, Kyonsoo; Guan, Kun-Liang (2004. )Activation of FAK and Src are receptor-proximal events required for netrin signaling.Nature neuroscience, ,7 (11 ),1213-21

Cooper, Lee Ann; Shen, Tang-Long; Guan, Jun-Lin (2003. )Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction. Molecular and cellular biology, ,23 (22 ),8030-41

Zhao, Jihe; Bian, Z Christine; Yee, Kristine; Chen, Benjamin P C; Chien, Shu; Guan, Jun-Lin (2003. )Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Molecular cell, ,11 (6 ),1503-15

Han, Dong Cho; Shen, Tang-Long; Miao, Hui; Wang, Bingcheng; Guan, Jun-Lin (2002. )EphB1 associates with Grb7 and regulates cell migration.The Journal of biological chemistry, ,277 (47 ),45655-61

Abbi, Smita; Ueda, Hiroki; Zheng, Chuanhai; Cooper, Lee Ann; Zhao, Jihe; Christopher, Renee; Guan, Jun-Lin (2002. )Regulation of focal adhesion kinase by a novel protein inhibitor FIP200.Molecular biology of the cell, ,13 (9 ),3178-91

Shen, Tang-Long; Han, Dong Cho; Guan, Jun-Lin (2002. )Association of Grb7 with phosphoinositides and its role in the regulation of cell migration.The Journal of biological chemistry, ,277 (32 ),29069-77

Goicoechea, Silvia M; Tu, Yizeng; Hua, Yun; Chen, Ka; Shen, Tang-Long; Guan, Jun-Lin; Wu, Chuanyue (2002. )Nck-2 interacts with focal adhesion kinase and modulates cell motility. The international journal of biochemistry & cell biology, ,34 (7 ),791-805

Chen, Qixin; Jin, Chengzhi; Shao, Xintian; Guan, Ruilin; Tian, Zhiqi; Wang, Chenran; Liu, Fei; Ling, Peixue; Guan, Jun-Lin; Ji, Liangnian; Wang, Fengshan; Chao, Hui; Diao, Jiajie (2018. )Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore.Small (Weinheim an der Bergstrasse, Germany), ,14 (41 ),e1802166

Li, Song; Butler, Peter; Wang, Yingxiao; Hu, Yingli; Han, Dong Cho; Usami, Shunichi; Guan, Jun-Lin; Chien, Shu (2002. )The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells.Proceedings of the National Academy of Sciences of the United States of America, ,99 (6 ),3546-51

Ho, Wan Yun; Tai, Yee Kit; Chang, Jer-Cherng; Liang, Jason; Tyan, Sheue-Houy; Chen, Song; Guan, Jun-Lin; Zhou, Huilin; Shen, Han-Ming; Koo, Edward; Ling, Shuo-Chien (2019. )The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy.Autophagy, ,1-16

Liu, Bingjie; Du, Ruikai; Zhou, Lei; Xu, Jiahui; Chen, Song; Chen, Ji; Yang, Xiaoli; Liu, Dong-Xu; Shao, Zhi-Ming; Zhang, Lixing; Yu, Zuoren; Xie, Ni; Guan, Jun-Lin; Liu, Suling (2018. )miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK1/?-Catenin Axis.Theranostics, ,8 (21 ),5801-5813

Huang, Huilin; Weng, Hengyou; Zhou, Keren; Wu, Tong; Zhao, Boxuan Simen; Sun, Mingli; Chen, Zhenhua; Deng, Xiaolan; Xiao, Gang; Auer, Franziska; Klemm, Lars; Wu, Huizhe; Zuo, Zhixiang; Qin, Xi; Dong, Yunzhu; Zhou, Yile; Qin, Hanjun; Tao, Shu; Du, Juan; Liu, Jun; Lu, Zhike; Yin, Hang; Mesquita, Ana; Yuan, Celvie L; Hu, Yueh-Chiang; Sun, Wenju; Su, Rui; Dong, Lei; Shen, Chao; Li, Chenying; Qing, Ying; Jiang, Xi; Wu, Xiwei; Sun, Miao; Guan, Jun-Lin; Qu, Lianghu; Wei, Minjie; Müschen, Markus; Huang, Gang; He, Chuan; Yang, Jianhua; Chen, Jianjun (2019. )Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally.Nature, ,567 (7748 ),414-419

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin (2016. )Correction: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.The Journal of cell biology, ,212 (7 ),879

Jeong, Kyuho; Kim, Jung-Hyun; Murphy, James M; Park, Hyeonsoo; Kim, Su-Jeong; Rodriguez, Yelitza; Kong, Hyunkyung; Choi, Chungsik; Guan, Jun-Lin; Taylor, Joan M; Lincoln, Thomas M; Gerthoffer, William T; Kim, Jun-Sub; Ahn, Eun-Young Erin; Schlaepfer, David D; Lim, Ssang-Taek Steve (2019. )Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-mediated Cyclin D1 Transcription.Circulation research, ,

Gao, Chenxi; Chen, Guangming; Zhang, Dennis Han; Zhang, Judy; Kuan, Shih-Fan; Hu, Wenhuo; Esni, Farzad; Gao, Xuan; Guan, Jun-Lin; Chu, Edward; Hu, Jing (2019. )PYK2 is involved in premalignant acinar cell reprogramming and pancreatic ductal adenocarcinoma maintenance by phosphorylating ?-cateninY654.Cellular and molecular gastroenterology and hepatology, ,

Zachari, Maria; Gudmundsson, Sigurdur R; Li, Ziyue; Manifava, Maria; Shah, Ronak; Smith, Matthew; Stronge, James; Karanasios, Eleftherios; Piunti, Caterina; Kishi-Itakura, Chieko; Vihinen, Helena; Jokitalo, Eija; Guan, Jun-Lin; Buss, Folma; Smith, Andrew M; Walker, Simon A; Eskelinen, Eeva-Liisa; Ktistakis, Nicholas T (2019. )Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform.Developmental cell, ,

Thomas, Neil; Choi, Han Kyoung; Wei, Xiaoxi; Wang, Li; Mishina, Yuji; Guan, Jun-Lin; Liu, Fei (2019. )Autophagy Regulates Craniofacial Bone Acquisition.Calcified tissue international, ,

Ogawa, Michinaga; Takada, Naoki; Shizukuishi, Sayaka; Tomokiyo, Mikado; Chang, Bin; Yoshida, Mitsutaka; Kakuta, Soichiro; Tanida, Isei; Ryo, Akihide; Guan, Jun-Lin; Takeyama, Haruko; Ohnishi, Makoto (2020. )Streptococcus pneumoniae triggers hierarchical autophagy through reprogramming of LAPosome-like vesicles via NDP52-delocalization.Communications biology, ,3 (1 ),25

Wu, Hsin-Jung; Hao, Mingang; Yeo, Syn Kok; Guan, Jun-Lin (2020. )FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication.Oncogene, ,

Deng, Shan; Essandoh, Kobina; Wang, Xiaohong; Li, Yutian; Huang, Wei; Chen, Jing; Peng, Jiangtong; Jiang, Ding-Sheng; Mu, Xingjiang; Wang, Chenran; Peng, Tianqing; Guan, Jun-Lin; Wang, Yigang; Jegga, Anil; Huang, Kai; Fan, Guo-Chang (2020. )Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.Redox biology, ,101453

Chen, Qixin; Shao, Xintian; Hao, Mingang; Fang, Hongbao; Guan, Ruilin; Tian, Zhiqi; Li, Miaoling; Wang, Chenran; Ji, Liangnian; Chao, Hui; Guan, Jun-Lin; Diao, Jiajie (2020. )Quantitative analysis of interactive behavior of mitochondria and lysosomes using structured illumination microscopy.Biomaterials, ,250 ,120059

Yang, Fuchun; Sun, Shaogang; Wang, Chenran; Haas, Michael; Yeo, Syn; Guan, Jun-Lin (2020. )Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation.British journal of cancer, ,

Qi, Shuqun; Sun, Xiumei; Choi, Han Kyoung; Yao, Jinfeng; Wang, Li; Wu, Guomin; He, Yun; Pan, Jian; Guan, Jun-Lin; Liu, Fei (2020. )FAK promotes early osteoprogenitor cell proliferation by enhancing mTORC1 signaling.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, ,

Paul, Ritama; Luo, Ming; Mo, Xueying; Lu, Jason; Yeo, Syn Kok; Guan, Jun-Lin (2020. )FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors.Breast cancer research : BCR, ,22 (1 ),59

Qiu, Kangqiang; Du, Yang; Liu, Jiyan; Guan, Jun-Lin; Chao, Hui; Diao, Jiajie (2020. )Super-resolution observation of lysosomal dynamics with fluorescent gold nanoparticles.Theranostics, ,10 (13 ),6072-6081

Yeo, Syn Kok; Wang, Chenran; Guan, Jun-Lin (2020. )Role of FIP200 in inflammatory processes beyond its canonical autophagy function.Biochemical Society transactions, ,

Paul, Ritama; Luo, Ming; Mo, Xueying; Lu, Jason; Yeo, Syn Kok; Guan, Jun-Lin (2020. )Correction to: FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors.Breast cancer research : BCR, ,22 (1 ),71

Okamoto, Takako; Yeo, Syn Kok; Hao, Mingang; Copley, Mary Rose; Haas, Michael A; Chen, Song; Guan, Jun-Lin (2020. )FIP200 suppresses immune checkpoint therapy responses in breast cancers by limiting AZI2/TBK1/IRF signaling independent of its canonical autophagy function.Cancer research, ,

Wang, Chenran; Haas, Michael A; Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R; Guan, Jun-Lin (2019. )Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells.Nature metabolism, ,1 (11 ),1127-1140

Xia, Houjun; Li, Shasha; Li, Xiong; Wang, Weichao; Bian, Yingjie; Wei, Shuang; Grove, Sara; Wang, Weimin; Vatan, Linda; Liu, J Rebecca; McLean, Karen; Rattan, Ramandeep; Munkarah, Adnan; Guan, Jun-Lin; Kryczek, Ilona; Zou, Weiping (2020. )Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis.JCI insight, ,5 (18 ),

Huang, Huilin; Weng, Hengyou; Sun, Wenju; Qin, Xi; Shi, Hailing; Wu, Huizhe; Zhao, Boxuan Simen; Mesquita, Ana; Liu, Chang; Yuan, Celvie L; Hu, Yueh-Chiang; Hüttelmaier, Stefan; Skibbe, Jennifer R; Su, Rui; Deng, Xiaolan; Dong, Lei; Sun, Miao; Li, Chenying; Nachtergaele, Sigrid; Wang, Yungui; Hu, Chao; Ferchen, Kyle; Greis, Kenneth D; Jiang, Xi; Wei, Minjie; Qu, Lianghu; Guan, Jun-Lin; He, Chuan; Yang, Jianhua; Chen, Jianjun (2020. )Publisher Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.Nature cell biology, ,

Yeo, Syn Kok; Zhu, Xiaoting; Okamoto, Takako; Hao, Mingang; Wang, Cailian; Lu, Peixin; Lu, Long Jason; Guan, Jun-Lin (2020. )Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer.eLife, ,9 ,

Yeo, Syn Kok; Guan, Jun-Lin (2020. )Regulation of immune checkpoint blockade efficacy in breast cancer by FIP200: A canonical-autophagy-independent function.Cell stress, ,4 (8 ),216-217

Post Graduate Training and Education

1987-1991 Center for Cancer Research, Massachusetts Institute of Technology, ,

Contact Information

Academic - Vontz Center for Molecular Studies
Room 3324
Cincinnati  Ohio, 45267
Phone: 513-558-0114
Fax: 513-558-1190
jun-lin.guan@uc.edu