Bryan Christopher Hambley , MD,MPH

I specialize in the care of patients with blood cancers and have particular expertise in the treatment of patients with leukemia, MDS, and rare hematologic disorders (such as aplastic anemia, other bone marrow failure conditions, and HLH). Within these diseases, I am interested in the role of autologous and allogeneic stem cell transplantation, as well as cellular therapies such as CAR T-cells.
 

Bachelor's Degree: University of Notre Dame South Bend, IN, 2007 (Pre-Professional Studies and Political Science)

Master's Degree: Tulane University School of Public Health New Orleans, LA, 2012 (Medicine and Health Systems Mangement)

Medical Degree: Tulane University School of Medicine Tulane LA , 2012

Internship: Case Western Reserve University Cleveland, OH, 2015 (Internal Medicine)

Chief Resident: Case Western Reserve University Cleveland, OH, 2016

Fellowship: Case Western Reserve University Cleveland, OH, 2017 (Critical Care)

Fellowship: Johns Hopkins Hospital Baltimore, MD, 2019 (Hematology)

Fellowship: Johns Hopkins Hospital Baltimore, MD, 2020 (Hematology)

American Board of Internal Medicine (Critical Care Medicine) (Certification Date: 12-15-2020 )

American Board of Internal Medicine (Hematology) (Certification Date: 10-25-2019 )

American Board of Internal Medicine (Certification Date: 08-11-2015 )

Critical Care Medicine

Hematology and Oncology

Leukemia

Acute Lymphocytic Leukemia

Acute Myeloid Leukemia

Amyloidosis

Castleman Disease

Chronic Lymphocytic Leukemia

Chronic Myelogenous Leukemia

Lymphadenopathy

Lymphoma

M Protein

Macrocytosis

Mediastinal Adenopathy

Monoclonal gammopathy

Monoclonal protein

M-Spike

Mycosis Fugoides

Myelodysplastic Syndrome

Myeloma

Myeloproliferative Disorder

Paraproteinemia

Plasma Cell Disorder

Plasminogen Activator Inhibitor 1

Polycythemia vera

Proteinuria

Sideroblastic anemia

T-cell lymphoma

Critical Care Medicine

Hematology

Internal Medicine

Grant: #Cellphire/BARDA TCP CTA Investigators:Cancelas Perez, Jose; Hambley, Bryan 03-01-2021 -12-31-2026 Biomedical Advanced Research and Development Authority A Prospective, Multicenter, Randomized, Open-Label Phase 2, Parallel, Dose Ranging Multidose Study of Thrombosomes® vs Liquid Stored Platelets (LSP) in Bleeding Thrombocytopenic Patients Role:Collaborator 0.00 Hold Level:Federal

Grant: #M19-063 03-01-2022 -03-01-2025 AbbVie, Inc. A Randomized, Open Label Phase 3 Study Evaluating Safety and Efficacy of Venetoclax incombination with Azacitidine after allogeneic Stem Cell Transplantation in Subjects with Acute MyeloidLeukemia Role:PI 2058730.53 Hold Level:Industry

Grant: #M19-063 03-01-2022 -03-01-2025 AbbVie, Inc. A Randomized, Open Label Phase 3 Study Evaluating Safety and Efficacy of Venetoclax incombination with Azacitidine after allogeneic Stem Cell Transplantation in Subjects with Acute MyeloidLeukemia Role:PI 2058730.53 Hold Level:Industry

Grant: #PKRPC001 Investigators:Hambley, Bryan 09-14-2023 -09-14-2026 Priothera S.A.S. A prospective randomized, double-blind, placebo-controlled, multi-center phase III study to evaluate the efficacy and safety of mocravimod as an adjunctive and maintenance treatment in adult acute mye Role:PI 630079.58 Hold Level:Industry

Peer Reviewed Publications

Bryan Hambley, Kelly Norsworthy, Jagar Jasem, Jacquelyn Zimmerman et al. (2019. ) Fibrinogen consumption and use of heparin are risk factors for delayed bleeding during acute promyelocytic leukemia induction .Leukemia Research, , More Information

Alex Ambinder, Bryan Hambley, Satish Shanbhag, and Sam Merrill (2019. ) Ibrutinib-associated hemophagocytic lymphohistiocytosis: A case series from Johns Hopkins .American Journal of Hematology, , More Information

Bryan Hambley, Paolo Caimi, and Basem William (2016. ) Bortezomib for the treatment of mantle cell lymphoma: an update .Therapeutic Advances in Hematology, , More Information

Eric Gehrie et al. (2019. ) One-unit compared to two-unit platelet transfusions for adult oncology outpatients .Vox Sanguinis, , More Information

VanDommelen, Kyle; Omer, Zulfa; Hambley, Bryan C; Stefaniuk, Catherine M (2022. ) Reversal of life-threatening bleeding with protamine sulfate in a patient with plasma cell leukemia.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, , 33 (7 ) ,425-428 More Information

Murdock, H Moses; Kim, Haesook T; Denlinger, Nathan; Vachhani, Pankit; Hambley, Bryan; Manning, Bryan S; Gier, Shannon; Cho, Christina; Tsai, Harrison K; McCurdy, Shannon; Ho, Vincent T; Koreth, John; Soiffer, Robert J; Ritz, Jerome; Carroll, Martin P; Vasu, Sumithira; Perales, Miguel-Angel; Wang, Eunice S; Gondek, Lukasz P; Devine, Steven; Alyea, Edwin P; Lindsley, R Coleman; Gibson, Christopher J (2022. ) Impact of diagnostic genetics on remission MRD and transplantation outcomes in older patients with AML.Blood, , 139 (24 ) ,3546-3557 More Information

Coriu, Daniel; Dirzu, Noemi; Zimta, Alina-Andreea; Hambley, Bryan C; Liu, Xiaojing; Nemes, Laszlo; Ghiaur, Gabriel; Mahlangu, Johny; Tomuleasa, Ciprian (2022. ) Editorial: Modern Approaches to Hemophilia Management: Gene Therapy and Beyond.Frontiers in medicine, , 9 ,859710 More Information

Hambley, Bryan C; Tomuleasa, Ciprian; Ghiaur, Gabriel (2021. ) Coagulopathy in Acute Promyelocytic Leukemia: Can We Go Beyond Supportive Care?.Frontiers in medicine, , 8 ,722614 More Information

Safi, Salahuddin; Shanbhag, Satish; Hambley, Bryan C; Merrill, Samuel A (2021. ) Systems controls are needed to reduce mistaken tests for hemophagocytic lymphohistiocytosis, results of a prospective quality-improvement cohort study.Medicine, , 100 (26 ) ,e26509 More Information

Trybula, Marcus; Wang, Diping; Baumann, Lauren; Pritts, Timothy A; Hambley, Bryan C (2021. ) Rhizopus microsporus typhlitis in a patient with acute myelogenous leukemia.Clinical case reports, , 9 (6 ) ,e04290 More Information

Book Chapter

Bryan Hambley and Amy DeZern (2020 ) Treatment Algorithms for Higher-Risk Disease Diagnosis and Management of Myelodysplastic Syndromes .

The Vontz Center for Molecular Studies
3125 Eden Ave
Cincinnati  Ohio, 45219
hamblebc@ucmail.uc.edu