Daewoo Han, PHD

Dr. Daewoo Han’s research activities are focused on devices and materials for bio/chem/medical/sensor applications. Currently and for the past several years that includes: (a) electrospun nanofiber membranes and their applications and (b) point-of-care diagnostic devices. Multi-functional nanofibers have emerged as a versatile and powerful nanomaterial, offering unprecedented potential in a variety of applications because of their unique benefits, such as extremely high surface area, highly porous network, and excellent flexibility for material selection, various fiber morphologies and structural configurations. ‘Synergism’ has been the cornerstone of the research strategy, not only in performing diverse research activities, but also in fostering collaborations with experts in complementary fields. 

Current research direction has been outlined but not limited to as following: (1) expanding the current biomedical research (e.g. drug delivery and wound dressing, etc.) by incorporating engineering methodologies, such as microfluidics and electronic controls; (2) stepping into emerging fields, such as nanofiber-based 3-D transistors mimicking a gate-all-around transistor and artificial intelligence (AI). AI-integrated point-of-care and sensor systems are gaining prominence due to the great potential enabling smarter, rapid, adaptive, and more elective solutions for real-time decision-making in healthcare and other critical sectors.

Ph.D.: University of Cincinnati , Cincinnati, OH USA, 2010 (Nanofibers & Point-of-Care Devices)

M.S.: Hoseo University, South Korea, 1998 (Optical Communication System)

B.S.: Hoseo University, South Korea, 1996 (Information & Telecommunication Eng.)

2014 -2025 Senior Research Associate , University of Cincinnati,, OH USA

2013 -2014 Research Associate , University of Cincinnati,, OH USA

2011 -2013 Postdoctoral Fellow , University of Cincinnati,, OH USA

Investigators:Cahay, Marc; Han, Daewoo; Mittal, Ankit; Steckl, Andrew 05-01-2027 -04-30-2029 INTEL Corporation Intel Scholarship for MS students Role:Collaborator 280000.00 Hold Level:Industry

Grant: #58-6054-6-036 Investigators:Han, Daewoo; Steckl, Andrew 07-15-2026 -07-14-2029 Department of Agriculture Development of Nanofiber-Based Value Added Agricultural Products Role:PI 150000.00 Hold Level:Federal

Peer Reviewed Publications

051. Han, Daewoo; Slika, Hasan; Shahani, Aanya; Wolf, Eliana S.; Eberhart, Charles G.; Brem, Henry, Tyler, Betty, Steckl, Andrew J.  (2026). Codelivery Material System of Polymer Microfiber Structures for Synergistic Localized Therapy of Glioblastoma. ACS Biomaterials Science & Engineering

050. D. Han, I. S. Weitz, H. Slika, B. Tyler, and A. J. Steckl  (2026). Combined Delivery of CuO Nanoparticles and HIF-1a Inhibitor Acriflavine for Synergistic Local Treatment of Glioblastoma. Advanced NanoBiomed Research, 6 (2) , e202500124

049. A. Steckl, D. Han, A. Adehinmoye, and P. Strobbia  (2025). Point-of-Care Sensors for Salivary Endotoxin Detection. 2025 IEEE SENSORS, Vancouver, BC, Canada, 1-4

048. A. Adehinmoye, D. Han, P. Strobbia, and A.J. Steckl  (2025). Picogram-level detection of endotoxin in human saliva using ultrasensitive surface enhanced Raman scattering in lateral flow assay devices. RSC Advances, 15, 39578-39586

047. Han, Daewoo; Horvath, Robert; Uner, Burcu; Pauletti, Giovanni M.; Steckl, Andrew J.  (2025). Skin-Compatible Carbopol Electrospun Fiber Membranes with pH-Dependent Rheological Properties for Biomedical Applications. Macromolecular Materials and Engineering, 310 (3 ) , 2400335

046. Kissell, Lyndsay N.; Han, Daewoo; Vang, Der; Cikanek, Alexander W. R.; Steckl, Andrew J.; Strobbia, Pietro  (2024). Improved point-of-care detection of P. gingivalis using optimized surface-enhanced Raman scattering in lateral flow assays. Sensors & Diagnostics, 2 (1 ) , 252-258

045. J. Huang; D. Han; A. J. Steckl  (2024). Flow-Cell Sensor for Bacteria Detection Using Gate-Modified Organic Electrochemical Transistor. IEEE Sensors Journal, 24 (5 ) , 5797-5805

044. D. Han, D. Vang, A. Adehinmoye, L. Kissell, P. Strobbia, and A.J. Steckl,  (2024). Rapid Point-of-Care LFA Diagnostics for Oral Health Using Optical Excitation/Detection Methods. Sensors, Actuators and Microsystems Workshop, Hilton Head, NC,, 320-323

043. Han, Daewoo; Xie, Sancai; Steckl, Andrew J.  (2023). Salivary endotoxin detection using combined mono/polyclonal antibody-based sandwich-type lateral flow immunoassay device. Sensors & Diagnostics, 2 (6 ) , 1460-1468

042. Campbell, Brooke; Anderson, Zoe; Han, Daewoo; Nebor, Ivanna; Forbes, Jonathan; Steckl, Andrew J.  (2022). Electrospinning of cyanoacrylate tissue adhesives for human dural repair in endonasal surgery. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 110 (3 ) , 660-667

041. Frantz, Eric; Huang, Jingchu; Han, Daewoo; Steckl, Andrew J.  (2022). The effect of nutrient broth media on PEDOT:PSS gated OECTs for whole-cell bacteria detection. Biosensors and Bioelectronics: X, 12 (24 ) , 100268

040. Tort, Serdar; Han, Daewoo; Frantz, Eric; Steckl, Andrew J.  (2021). Controlled drug release of parylene-coated pramipexole nanofibers for transdermal applications. Surface and Coatings Technology, 409 (10 ) , 126831

039. Dalirirad, Shima; Han, Daewoo; Steckl, Andrew J.  (2020). Aptamer-Based Lateral Flow Biosensor for Rapid Detection of Salivary Cortisol. ACS Omega, 5 (51 ) , 32890â??32898

038. Tort, Serdar; Han, Daewoo; Steckl, Andrew J.  (2020). Self-inflating floating nanofiber membranes for controlled drug delivery. International Journal of Pharmaceutics, 579 (49) , 119164

037. Han, Daewoo; Ray, Prajokta; Dalirirad, Shima; Steckl, Andrew.  (2020). Novel point of care strategies for biomarker detection. Scientific Reports, 9 (1 ) , 1-2

036. Tort, Serdar; Agardan, Necibe Basaran Mutlu; Han, Daewoo; Steckl, Andrew J.  (2020). In vitro and in vivo evaluation of microneedles coated with electrosprayed micro/nanoparticles for medical skin treatments. J. Microencapsul., 37 (7) , 517–527

035. Han, Daewoo; Steckl, Andrew J.  (2019). Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications. ChemPlusChem, 84 (10 ) , 1453-1497

034. Han, Daewoo; Serra, Riccardo; Gorelick, Noah; Fatima, Umailla; Eberhart, Charles G.; Brem, Henry; Tyler, Betty; Steckl, Andrew J.  (2019). Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor. Scientific Reports, 9 (1 ) , 17936

033. Tirgar, Ashkan; Han, Daewoo; Steckl, Andrew J.  (2018). Absorption of Ethylene on Membranes Containing Potassium Permanganate Loaded into Alumina-Nanoparticle-Incorporated Alumina/Carbon Nanofibers. Journal of Agricultural and Food Chemistry, 66 (22 ) , 5635-5643

032. Li, Hua; Han, Daewoo; Pauletti, Giovanni M; Hegener, Michael A.; Steckl, Andrew J.  (2018). Correcting the effect of hematocrit in whole blood coagulation analysis on paper-based lateral flow device. Analytical Methods, 10 (24 ) , 2869-2874

031. Li, Hua; Han, Daewoo; Pauletti, Giovanni M.; Steckl, Andrew J.  (2018). Engineering a simple lateral flow device for animal blood coagulation monitoring. Biomicrofluidics, 12 (1 ) , 9315-9321

030. Majd, Nazanin; Han, Dawewoo; Sasaki, Mika; Yoshino, Hirofumi; Satoshi, Kofuji; Chaudhary, Rekha; Warnick, Ronald; Steckl, Andrew; Sasaki, Atsuo  (2017). EXTH-47. DEVELOPMENT OF NANOFIBER-BASED CONTROLLED LOCAL DRUG DELIVERY AS A NOVEL ADJUVANT MODALITY FOR TREATMENT OF GLIOBLASTOMA. Neuro-Oncology, 19 (suppl_6 ) , vi82-vi82

029. Li, H.; Han, D.; Hegener, M. A.; Pauletti, G. M.; Steckl, A. J.  (2017). Flow reproducibility of whole blood and other bodily fluids in simplified no reaction lateral flow assay devices. Biomicrofluidics, 11 (2 ) , vi82-vi82

028. Han, Daewoo; Yu, Xinjun; Chai, Qinyuan; Ayres, Neil; Steckl, Andrew J.  (2017). Stimuli-Responsive Self-Immolative Polymer Nanofiber Membranes Formed by Coaxial Electrospinning. ACS Applied Materials & Interfaces, 9 (13 ) , 11858-11865

027. Hegener, Michael A.; Li, Hua; Han, Daewoo; Steckl, Andrew J.; Pauletti, Giovanni M.  (2017). Point-of-care coagulation monitoring: first clinical experience using a paper-based lateral flow diagnostic device. Biomedical Microdevices, 19 (3 ) , 64

026. Han, Daewoo; Steckl, Andrew J.  (2017). Selective pH-Responsive Coreâ??Sheath Nanofiber Membranes for Chem/Bio/Med Applications: Targeted Delivery of Functional Molecules. ACS Appl. Mater. Interfaces, 9 (49 ) , 42653-42660

025. Han, Daewoo; Sasaki, Mika; Yoshino, Hirofumi; Kofuji, Satoshi; Sasaki, Atsuo T.; Steckl, Andrew J.  (2017). In-vitro evaluation of MPA-loaded electrospun coaxial fiber membranes for local treatment of glioblastoma tumor cells. J. Drug Delivery Sci. Technol., 40 (7 ) , 45-50

024. Han, Daewoo; Sherman, Shalli; Filocamo, Shaun; Steckl, Andrew J.  (2017). Long-term Antimicrobial Effect of Nisin Released from Electrospun Triaxial Fiber Membranes. Acta Biomater., 53 (7 ) , 242-249

022. Han, D.; Sherman, S; Filocamo, S; Steckl, A. J.  (2016). Anti-Microbial Effect of Nisin Released from Electrospun Tri-Layer Coaxial Fiber Membranes. ACS Biomater. Sci. & Eng., 66 (22 ) , 5635-5643

023. Ray, Prajokta; Han, Daewoo; Steckl, Andrew J.  (2016). Urine-powered (galvanic) electric cell and sensor on paper substrate. Flexible and Printed Electronics, 1 (4 ) , 044002

021. Zhao, Daoli; Wang, Tingting; Han, Daewoo; Rusinek, Cory; Steckl, Andrew J.; Heineman, William R.  (2015). Electrospun Carbon Nanofiber Modified Electrodes for Stripping Voltammetry. Analytical Chemistry, 87 (18 ) , 9315-9321

020. Blumenschein, N.; Han, D.; Steckl, A. J.  (2015). Phase Diagram Characterization Using Magnetic Beads as Liquid Carriers. J Vis Exp, 9 (103 ) , 1-2

017. Blumenschein, Nicholas A.; Han, Daewoo; Caggioni, Marco; Steckl, Andrew J.  (2014). Magnetic Particles as Liquid Carriers in the Microfluidic Lab-in-Tube Approach To Detect Phase Change. ACS Applied Materials & Interfaces, 6 (11 ) , 8066-8072

019. Fraiwan, A.; Adusumilli, S. P.; Han, D.; Steckl, A. J.; Call, D. F.; Westgate, C. R.; Choi, S.  (2014). Microbial power-generating capabilitie on micro-/nano-structured anodes in micro-sized microbial fuel cells. Fuel Cells, 14 (6 ) , 801-809

018. Li, H.; Han, D.; Pauletti, G. M.; Steckl, A. J.  (2014). Blood coagulation screening using a paper-based microfluidic lateral flow device. Lab on a Chip, 14 (20 ) , 4035-4041

016. Fraiwan, A.; Sundermier, S.; Han, D.; Steckl, A. J.; Hassett, D. J.; Choi, S.  (2013). Enhanced performance of micro-electro-mechanical-systems (MEMS) microbial fuel cells using electrospun microfibrous anode and optimizing operation. Fuel Cells, 13 (3 ) , 336-341

015. Han, Daewoo; Steckl, Andrew J.  (2013). Triaxial Electrospun Nanofiber Membranes for Controlled Dual Release of Functional Molecules. ACS Appl. Mater. Interfaces, 5 (16 ) , 8241-8245

013. Han, D.; Li, H.; Lu, T. M.; Steckl, A. J.  (2011). Unidirectional self-patterning of CaF2 nanorod arrays using capillary pressure. Journal of Materials Research, 26 (2 ) , 223-229

012. Han, D.; Filocamo, S.; Kirby, R.; Steckl, A. J.  (2011). Deactivating Chemical Agents Using Enzyme-Coated Nanofibers Formed by Electrospinning. ACS Appl. Mater. Interfaces, 3 (24 ) , 4633-4639

011. Steckl, Andrew J.; Han, Daewoo  (2010). Electrospinning hydrophobic coaxial fibers into superhydrophobic oleophobic coaxial fiber mats, by ejecting a core solution from the core outlet of a nozzle and ejecting a hydrophobic sheath solution from the sheath outlet of the nozzle. Biosensors and Bioelectronics: X, 12 (Copyright (C) 2020 American Chemical Society (ACS). All Rights Reserved. ) , 14pp.

010. Wu, D.; Han, D.; Steckl, A. J.  (2010). Immunoassay on free-standing electrospun membranes. ACS Applied Materials and Interfaces, 2 (1 ) , 252-258

009. Han, Daewoo; Steckl, Andrew J.  (2009). Superhydrophobic and Oleophobic Fibers by Coaxial Electrospinning. Langmuir, 25 (16 ) , 9454-9462

007. Han, D.; Boyce, S. T.; Steckl, A. J.  (2008). Versatile core-sheath biofibers using coaxial electrospinning. Mater. Res. Soc. Symp. Proc., 1094 (4 ) , 1094-DD06-02

001. Han, D.; Lee, H.; Ahn S.; Cho H.  (1998). Simulation of polarization mode dispersion in birefringent optical fiber using the split step finite element method. KICS Annual Conference, 9-1, 553-556

002. Han, D. and Lee, H.  (1998). Analysis of nonlinear pulse propagation in optical fiber with random mode coupling using split-step FEM. 15th Optics and Quantum Electronics Conference, 15, 36-37

003. Lee, S.; Han, D.; Lee, H.; Kim, K.  (1999). Signal processing system of multi-fiber Bragg grating strain sensor using wavelength scanning-locking of a Fabry-Perot tunable filter. Journal of Korean Institute of Communication Sciences, 24 (8B) , 1472-1479

004. Han, D.; Lee, H.; Jung, B.  (2000). Analysis of polarization mode dispersion in nonlinear optical pulse propagation by SS-FEM adopting approximated sparse matrix. Journal of Korea Institute of Communication Sciences, 25 (6A) , 825-832

005. Steckl, A. J.; Hagen, J. A.; Yu, Z.; Jones, R. A.; Li, W.; Han, D.; Kim, D. Y.; Spaeth, H.  (2006). Challenges and Opportunities for Biophotonic Devices in the Liquid state and the Solid state. Proc. IEEE Conference on Nanotechnology, 159-161

006. Steckl, Andrew J.; Hagen, Joshua A.; Yu, Zhou; Jones, Robert A.; Li, Weixin; Han, Daewoo; Kim, Duk Y.; Spaeth, Hans; Grote, James G.; Hopkins, F. K  (2006). Biopolymers in Light Emitting Devices. Proc. 26th Int’l. Display Res. Conf, 25-27

008. Bedford, N.; Han, D.; Steckl, A. J.  (2008). Electrospun Biopolymer-Based Micro/Nanofibers. 17th Biennial UGIM Symp. Proc., 139-141

014. Fraiwan, A.; Sundermier, S.; Han, D.; Steckl, A.; Hassett, D. J.; Choi, S.  (2012). Challenges in Development and Operation of MEMS Microbial Fuel Cells. Proc. of PowerMEMS, 383-386

Bioelectronics Laboratory
901 Rhodes Hall, University of Cincinnati
Cincinnati  Ohio, 45221
hand@ucmail.uc.edu