Jiukuan Hao

Jiukuan Hao

Associate Professor

Professional Summary

My researches focus on delivery of macromolecules (oligonucleotides, proteins, genes) into brain and brain ischemia stroke.


M.D. : China Medical University Shenyang China, (Medicine)

M.S. : China Medical University Shenyang China, (Neurology)

PhD.: Texas Tech University Amarillo, TX, (Pharmaceutical Science )

Positions and Work Experience

- Assistant Professor , University of Cincinnati, Cincinnati OH

Research Support

Grant: #12BGIA9090000 Investigators:Hao, Jiukuan 01-01-2012 -12-31-2013 American Heart Association - Great Rivers Affiliate Therapy of Stroke with Novel Neuroprotective RNA Nanoparticles Role:PI $131,740.00 Active Level:Private Non-Profit

Grant: #RRIA 2012 Investigators:Hao, Jiukuan 05-08-2012 -09-30-2013 Michael J. Fox Foundation for Parkinson's Research The Mifunctional Cembranoids for Therapy of Parkinson's Disease Role:PI $74,999.10 Active Level:Private Non-Profit

Grant: #2013-PH-012SR Investigators:Hao, Jiukuan 07-01-2013 -06-30-2014 Maine Cancer Foundation Inhibition of Intercellular Adhesion Molecule-1 in Lung Cancer Cells by Selective SiRNA Nanoparticles Role:PI $11,500.00 Awarded Level:Private Non-Profit

Grant: #R15NS088384 Investigators:Gudelsky, Gary; Hao, Jiukuan 04-01-2015 -03-31-2018 National Institute of Neurological Disorders and Stroke Targeting the Blood-Brain Barrier in Ischemic Stroke Role:PI $487,203.00 Awarded Level:Federal

Grant: #R21NS093493-01 Investigators:Hao, Jiukuan; Xie, Changchun 06-01-2015 -05-31-2017 National Institute of Neurological Disorders and Stroke Application of Brain-Targeted Anti-inflammatory RNA Nanoparticle for Ischemic Stroke Therapy Role:PI $205,506.00 Awarded Level:Federal

Grant: #R01 HL140962 Investigators:Hao, Jiukuan; Hui, David; Liu, Min; Millard, Ronald; Wang, Yi-Gang; Xu, Meifeng 03-15-2018 -01-31-2022 National Heart, Lung and Blood Institute Smarter exosomes derived from engineered MSCs promote neo-vascularization Role:Collaborator $502,815.00 Active Level:Federal

Grant: #R01NS105787 Investigators:Hao, Jiukuan; Xu, Meifeng 06-30-2018 -07-31-2023 National Institute of Neurological Disorders and Stroke Targeting the Hippo signaling at the Blood-brain barrier for therapy of ischemic stroke Role:PI $356,435.00 Awarded Level:Federal


Peer Reviewed Publications

Hu, Jing; Mu, Chaofeng; Hao, Jiukuan (2013. ) Cerebral ischemia reduces expression of Hs1-associated protein X-1 (Hax-1) in mouse brain.Neuroscience letters, , 534 ,338-43 More Information

Mu, Chaofeng; Dave, Nimita; Hu, Jing; Desai, Pankaj; Pauletti, Giovanni; Bai, Shuhua; Hao, Jiukuan (2013. ) Solubilization of flurbiprofen into aptamer-modified PEG-PLA micelles for targeted delivery to brain-derived endothelial cells in vitro.Journal of microencapsulation, , 30 (7 ) ,701-8 More Information

Hao, Jiukuan; Bickel, Ulrich (2013. ) Transferrin receptor mediated brain uptake during ischemia and reperfusion. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques, , 16 (4 ) ,541-50

Yang, Tianzhi; Nyiawung, Divine; Silber, Alexandra; Hao, Jiukuan; Lai, Leanne; Bai, Shuhua (2012. ) Comparative studies on chitosan and polylactic-co-glycolic acid incorporated nanoparticles of low molecular weight heparin.AAPS PharmSciTech, , 13 (4 ) ,1309-18 More Information

Hao, Jiukuan; Mdzinarishvili, Alexander; Abbruscato, Thomas J; Klein, Jochen; Geldenhuys, Werner J; Van der Schyf, Cornelis J; Bickel, Ulrich (2008. ) Neuroprotection in mice by NGP1-01 after transient focal brain ischemia.Brain research, , 1196 ,113-20 More Information

Ferchmin, P A; Hao, Jiukuan; Perez, Dinely; Penzo, Mario; Maldonado, Hector M; Gonzalez, Maria T; Rodriguez, Abimael D; de Vellis, Jean (2005. ) Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptors.Journal of neuroscience research, , 82 (5 ) ,631-41 More Information

Hu, Jing; Xiao, Feng; Hao, Xin; Bai, Shuhua; Hao, Jiukuan (2014. ) Inhibition of monocyte adhesion to brain-derived endothelial cells by dual functional RNA chimeras.Molecular therapy. Nucleic acids, , 3 ,e209 More Information