Kevin Haworth , PhD

Kevin Haworth received a B.S. degree in physics from Truman State University in 2003 and M.S. and Ph.D. degrees in applied physics from the University of Michigan, Ann Arbor, MI, in 2006 and 2009, respectively.  Following his graduate studies he performed a postdoctoral fellowship at the University of Cincinnati.  As a fellow, he received a Ruth L Kirschstein National Research Service Award (F32) from the NIH National Heart, Lung, and Blood Institute to support his research. He is an Associate Professor in the Division of Cardiovascular Health and Disease within the Department Internal Medicine, College of Medicine at the University of Cincinnati.  He also maintains a secondary faculty appointment within the Department of Pediatrics and the Department of Biomedical Engineering, College of Engineering and Applied Science at the University of Cincinnati. Dr. Haworth teaches and is the Director of Data and Analytics for the College of Medicine’s Medical Sciences Baccalaureate Program. Additionally, he teaches at both the undergraduate and graduate level in the Department of Biomedical Engineering.  Dr. Haworth is a member of the IEEE (senior grade) and the International Society for Therapeutic Ultrasound (ISTU). He is a fellow member of the Acoustical Society of America (ASA), and the American Institute of Ultrasound in Medicine (AIUM).  He serves on the Bioeffects Committee and Technical Standards Committees, is an elected member of the Board of Governors, and serves as the Vice Chair of the Basic Science and Instrumentation Community of practice at the AIUM. He is a member of the Biomedical Acoustic Technical Committee and Public Relations Committee for the ASA. He is a former Goldwater Scholar and is involved with the Barry M. Goldwater Scholarship and Excellence in Education Program at both the local and national level. 

Kevin Haworth’s research interests broadly include biomedical ultrasound imaging and therapy.  In particular, he is currently directing and conducting research in medical ultrasound including the use of bubbles for diagnostic and therapeutic applications. His work includes studies of cavitation imaging and acoustic droplet vaporization for gas scavenging and imaging. These studies have been funded through the National Institutes of Health, the American Heart Association, and institutional awards. Ongoing studies of passive cavitation imaging are being pursued to develop image-guidance for cavitation-based therapies such as drug delivery and histotripsy. He has also developed research tools to enable ultrasound-mediated blood brain barrier disruption.  Additional studies are being performed to modify the imaging algorithm for improved image quality. Dr. Haworth is the principal investigator of an NIH-NHLBI R01 grant entitled "Ultrasound-mediated controlled hypoxemic reperfusion for inhibition of reperfusion injury.” While new therapies to restore blood flow during myocardial infarction (i.e., a heart attack) can be life-saving, up to half of the volume of heart tissue at risk during a heart attack dies, paradoxically, due to the return of blood flow. The previously oxygen-started heart muscle responds to the influx of oxygen by creating free radicals that damage the patient’s heart cells, so-called reperfusion injury.  This project uses a novel, ultrasound-mediated technique to sequester oxygen from the blood to limit free radical formation and reduce reperfusion injury.

med.uc.edu/depart/intmed/research/faculty-researchers/kevin-haworth

Bachelor's Degree: Truman State University Kirksville, MO, 2003 (Physics, Minor in Mathematics; Summa Cum Laude, General and Departmental Honors)

Master's Degree: University of Michigan Ann Arbor, MI, 2006 (Applied Physics)

Doctoral Degree: University of Michigan Ann Arbor, MI, 2009 (Applied Physics)

Postdoctoral Fellowship: University of Cincinnati Cincinnati, OH, 2010 (Biomedical Engineering)

Postdoctoral Fellowship: University of Cincinnati Cincinnati, OH, 2012 (Internal Medicine)

I am interested in understanding the physical mechanisms behind bubble-enhanced ultrasound biotherapies and application of the acoustic signatures of insonified bubbles.  This creates a research program that spans acoustics, signal processing, imaging, and medicine. Two current foci of my work are passive acoustic mapping and acoustic droplet vaporization for the treatment of cardiovascular disease.

07-01-2012 -09-2019 Assistant Professor of Internal Medicine, Secondary Appointments in Biomedical Engineering and Pediatrics, University of Cincinnati, Cincinnati, Ohio

09-01-2010 -06-30-2012 Ruth L. Kirschstein NRSA Postdoctoral Fellow, A fellow via an NIH F32 fellowship award under the mentorship of Christy K. Holland, University of Cincinnati, Cincinnati, Ohio

09-01-2009 -08-31-2010 Postdoctoral Fellow, Working for Christy K. Holland with the Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio

2008 -2009 Rackham Predoctoral Fellow, A one-year fellowship awarded by the Horace H. Rackham Graduate School at the University of Michigan, University of Michigan, Ann Arbor, Michigan

2003 -2008 Applied Physics Fellow and Graduate Student Research Assistant, University of Michigan, Ann Arbor, Michigan

10-2019 -To Present Associate Professor of Internal Medicine, University of Cincinnati, Cincinnati, Ohio

2017 -To Present Director of Data and Analytics, Medical Sciences Baccalaureate Program, University of Cincinnati, Cincinnati, OH USA

Grant: #Pilot Grant Investigators:Christy K. Holland, Vladimir Bogdanov, Kevin J. Haworth, Jack Rubinstein 04-01-2012 -06-30-2013 UC Cardiovascular Center of Excellence Ultrasound-Triggered Phase-Shift Emulsions for Thrombolysis Role:Collaborator 10,000 Completed Type:Grant Level:College

Grant: #8 KL2 TR000078-05 Investigators:Kevin J. Haworth 04-01-2013 -03-31-2015 National Institutes of Health via the UC-CCHMC-VAMC CCTST Multifunctional ultrasound-triggered emulsions for ischemic stroke. Role:PI 200000 Active Type:Grant

Grant: #Rehn Family Research Award Investigators:Kevin J. Haworth, Christy K. Holland, David D. McPherson, Melvin E. Klegerman 08-01-2013 -07-31-2014 University of Cincinnati Department of Internal Medicine Ultrasound-triggered phase-shift emulsions for molecular imaging of atheroma Role:PI 13500 Active Type:Grant

Grant: #F32 HL104916 Investigators:Haworth, Kevin; Holland, Christy; Mast, T. Douglas 09-01-2010 -08-31-2012 National Heart, Lung and Blood Institute Passive Cavitation Image-Guided Ultrasound-Mediated Drug Delivery for Atheroma Therapy Role:PI $102,974.00 Closed Level:Federal

Grant: #16SDG27250231 Investigators:Haworth, Kevin 01-01-2016 -12-31-2019 American Heart Association - National Chapter Ultrasound-mediated Oxygen Scavenging for Inhibition of Reperfusion Injury Role:PI $77,000.00 Awarded Level:Private Non-Profit

Grant: #URC Interdisciplinary Award AY2015-16 Investigators:Haworth, Kevin; Holland, Christy; Papautsky, Ian 05-01-2016 -04-30-2017 UC's University Research Council MICROFLUIDIC MANUFACTURING OF PERFLUOROCARBON DROPLETS FOR ACOUSTIC DROPLET VAPORIZATION Role:PI $25,000.00 Active Level:Internal UC

Grant: #K25 HL133452 Investigators:Haworth, Kevin 08-01-2016 -06-30-2020 National Heart, Lung and Blood Institute Ultrasound-mediated oxygen scavenging for inhibition of reperfusion injury Role:PI $156,799.00 Active Level:Federal

Grant: #FP066598-B / R01 HL133334 Investigators:Baded, Kenneth; Haworth, Kevin; Holland, Christy; Lynch, Donald 12-15-2017 -11-30-2022 National Heart, Lung and Blood Institute Chronic thrombus ablation with histotripsy and thrombolytics Role:Collaborator $220,899.00 Active Type:Grant Level:National

Grant: #2016 Robert W. Young Award Investigators:Haworth, Kevin; Wanek, Austin 10-01-2016 -05-31-2017 Acoustical Society of America Investigation of the Relationship Between Hemolysis and Acoustic Droplet Vaprorization Role:PI $500.00 Awarded Level:Private Non-Profit

Grant: #Robert W. Young Award for Undergraduate Student Research in Acoustics Investigators:Haworth, Kevin; Jahanpanah, Newsha 09-01-2018 -04-30-2019 Acoustical Society of America Acoustical Society - Newsha Jahanpanah (student for Dr. Haworth) Role:PI $500.00 Awarded Level:Private Non-Profit

Grant: #R01 HL148451 Investigators:Haworth, Kevin; Holland, Christy; Lorenz, John 07-01-2019 -04-30-2024 National Heart, Lung and Blood Institute Ultrasound-mediated Controlled Hypoxemic Reperfusion for Inhibition of Reperfusion Injury Role:PI $773,375.00 Awarded Level:Federal

Grant: #UTHSC / R01 HL135092 Investigators:Haworth, Kevin; Holland, Christy 04-15-2017 -03-31-2022 National Heart, Lung and Blood Institute Echogenic Targeted Liposomes: Transfection/Drug Delivery Role:Collaborator $285,512.00 Active Level:Federal

Investigators:Haworth, Kevin; Holland, Christy 09-01-2023 -05-31-2024 Lantheus Holdings, Inc. Assessment of Cavitation from Lantheus Contrast Agents Role:Collaborator 128561.28 Hold Level:Industry

Investigators:Haworth, Kevin; Holland, Christy 09-01-2023 -05-31-2024 Lantheus Holdings, Inc. Assessment of Cavitation from Lantheus Contrast Agents Role:Collaborator 0.00 Hold Level:Industry

Grant: #AWD105039 (SUB00001255) (R01HL133334) Investigators:Haworth, Kevin 09-01-2024 -07-31-2028 National Heart, Lung and Blood Institute Treatment of chronic venous thrombosis with histotripsy and thrombolytics Role:PI 116852.00 Hold Level:Federal

Peer Reviewed Publications

Radhakrishnan, Kirthi; Haworth, Kevin J; Huang, Shao-Ling; Klegerman, Melvin E; McPherson, David D; Holland, Christy K (2012. ) Stability of echogenic liposomes as a blood pool ultrasound contrast agent in a physiologic flow phantom.Ultrasound in medicine & biology, , 38 (11 ) ,1970-81 More Information

Haworth, Kevin J; Mast, T Douglas; Radhakrishnan, Kirthi; Burgess, Mark T; Kopechek, Jonathan A; Huang, Shao-Ling; McPherson, David D; Holland, Christy K (2012. ) Passive imaging with pulsed ultrasound insonations.The Journal of the Acoustical Society of America, , 132 (1 ) ,544-53 More Information

Kopechek, Jonathan A; Haworth, Kevin J; Raymond, Jason L; Douglas Mast, T; Perrin, Stephen R; Klegerman, Melvin E; Huang, Shaoling; Porter, Tyrone M; McPherson, David D; Holland, Christy K (2011. ) Acoustic characterization of echogenic liposomes: frequency-dependent attenuation and backscatter.The Journal of the Acoustical Society of America, , 130 (5 ) ,3472-81 More Information

Zhang, Man; Fabiilli, Mario L; Haworth, Kevin J; Padilla, Frederic; Swanson, Scott D; Kripfgans, Oliver D; Carson, Paul L; Fowlkes, Jeffrey Brian (2011. ) Acoustic droplet vaporization for enhancement of thermal ablation by high intensity focused ultrasound.Academic radiology, , 18 (9 ) ,1123-32 More Information

Hitchcock, Kathryn E; Ivancevich, Nikolas M; Haworth, Kevin J; Caudell Stamper, Danielle N; Vela, Deborah C; Sutton, Jonathan T; Pyne-Geithman, Gail J; Holland, Christy K (2011. ) Ultrasound-enhanced rt-PA thrombolysis in an ex vivo porcine carotid artery model.Ultrasound in medicine & biology, , 37 (8 ) ,1240-51 More Information

Fabiilli, Mario L; Haworth, Kevin J; Sebastian, Ian E; Kripfgans, Oliver D; Carson, Paul L; Fowlkes, J Brian (2010. ) Delivery of chlorambucil using an acoustically-triggered perfluoropentane emulsion.Ultrasound in medicine & biology, , 36 (8 ) ,1364-75 More Information

Fabiilli, Mario L; Haworth, Kevin J; Fakhri, Nasir H; Kripfgans, Oliver D; Carson, Paul L; Fowlkes, J Brian (2009. ) The role of inertial cavitation in acoustic droplet vaporization.IEEE transactions on ultrasonics, ferroelectrics, and frequency control, , 56 (5 ) ,1006-17 More Information

Haworth, Kevin J; Fowlkes, J Brian; Carson, Paul L; Kripfgans, Oliver D (2009. ) Generalized shot noise model for time-reversal in multiple-scattering media allowing for arbitrary inputs and windowing.The Journal of the Acoustical Society of America, , 125 (5 ) ,3129-40 More Information

Haworth, Kevin J; Fowlkes, J Brian; Carson, Paul L; Kripfgans, Oliver D (2008. ) Towards aberration correction of transcranial ultrasound using acoustic droplet vaporization.Ultrasound in medicine & biology, , 34 (3 ) ,435-45 More Information

Zhang, M; Fabiilli, M L; Haworth, K J; Fowlkes, J B; Kripfgans, O D; Roberts, W W; Ives, K A; Carson, P L (2010. ) Initial investigation of acoustic droplet vaporization for occlusion in canine kidney.Ultrasound in medicine & biology, , 36 (10 ) ,1691-703 More Information

Bader, Kenneth B; Radhakrishnan, Kirthi; Haworth, Kevin J; Raymond, Jason L; Huang, Shao-Ling; Peng, Tao; McPherson, David D; Holland, Christy K (2013. ) Modeling the loss of echogenicity from ultrasound contrast agents.The Journal of the Acoustical Society of America, , 134 (5 ) ,3977 More Information

Radhakrishnan, Kirthi; Bader, Kenneth B; Haworth, Kevin J; Kopechek, Jonathan A; Raymond, Jason L; Huang, Shao-Ling; McPherson, David D; Holland, Christy K (2013. ) Relationship between cavitation and loss of echogenicity from ultrasound contrast agents.Physics in medicine and biology, , 58 (18 ) ,6541-63 More Information

Kopechek, Jonathan A; Haworth, Kevin J; Radhakrishnan, Kirthi; Huang, Shao-Ling; Klegerman, Melvin E; McPherson, David D; Holland, Christy K (2013. ) The impact of bubbles on measurement of drug release from echogenic liposomes.Ultrasonics sonochemistry, , 20 (4 ) ,1121-30 More Information

Littleton, Robert M; Haworth, Kevin J; Tang, Hong; Setchell, Kenneth D R; Nelson, Sandra; Hove, Jay R (2013. ) Automated in vivo platform for the discovery of functional food treatments of hypercholesterolemia.PloS one, , 8 (1 ) ,e52409 More Information

Koch, Sheryl E; Haworth, Kevin J; Robbins, Nathan; Smith, Margaret A; Lather, Navneet; Anjak, Ahmad; Jiang, Min; Varma, Priyanka; Jones, W Keith; Rubinstein, Jack (2013. ) Age- and Gender-Related Changes in Ventricular Performance in Wild-Type FVB/N Mice as Evaluated by Conventional and Vector Velocity Echocardiography Imaging: A Retrospective Study.Ultrasound in medicine & biology, , 39 (11 ) ,2034 More Information

Raymond, Jason L; Haworth, Kevin J; Bader, Kenneth B; Radhakrishnan, Kirthi; Griffin, Joseph K; Huang, Shao-Ling; McPherson, David D; Holland, Christy K (2014. ) Broadband Attenuation Measurements of Phospholipid-Shelled Ultrasound Contrast Agents.Ultrasound in medicine & biology, , 40 (2 ) ,410 More Information

Radhakrishnan, Kirthi; Haworth, Kevin J; Peng, Tao; McPherson, David D; Holland, Christy K (2015. ) Loss of echogenicity and onset of cavitation from echogenic liposomes: pulse repetition frequency independence.Ultrasound in medicine & biology, , 41 (1 ) ,208-21 More Information

Sutton, Jonathan T; Haworth, Kevin J; Pyne-Geithman, Gail; Holland, Christy K (2013. ) Ultrasound-mediated drug delivery for cardiovascular disease.Expert opinion on drug delivery, , 10 (5 ) ,573-92 More Information

Haworth, Kevin J; Weidner, Christopher R; Abruzzo, Todd A; Shearn, Jason T; Holland, Christy K (2014. ) Mechanical properties and fibrin characteristics of endovascular coil-clot complexes: relevance to endovascular cerebral aneurysm repair paradigms.Journal of neurointerventional surgery, , More Information

Haworth, Kevin J; Salgaonkar, Vasant A; Corregan, Nicholas M; Holland, Christy K; Mast, T Douglas (2015. ) Using Passive Cavitation Images to Classify High-Intensity Focused Ultrasound Lesions.Ultrasound in medicine & biology, , 41 (9 ) ,2420-34 More Information

Haworth, Kevin J; Raymond, Jason L; Radhakrishnan, Kirthi; Moody, Melanie R; Huang, Shao-Ling; Peng, Tao; Shekhar, Himanshu; Klegerman, Melvin E; Kim, Hyunggun; McPherson, David D; Holland, Christy K (2015. ) Trans-Stent B-Mode Ultrasound And Passive Cavitation Imaging.Ultrasound in medicine & biology, , More Information

Sutton, J T; Haworth, K J; Shanmukhappa, S K; Moody, M R; Klegerman, M E; Griffin, J K; Patton, D M; McPherson, D D; Holland, C K (2016. ) Delivery of bevacizumab to atheromatous porcine carotid tissue using echogenic liposomes.Drug delivery, , 23 (9 ) ,3594-3605 More Information

Bader, Kenneth B; Haworth, Kevin J; Shekhar, Himanshu; Maxwell, Adam D; Peng, Tao; McPherson, David D; Holland, Christy K (2016. ) Efficacy of histotripsy combined with rt-PA in vitro.Physics in medicine and biology, , 61 (14 ) ,5253-74 More Information

Radhakrishnan, Kirthi; Holland, Christy K; Haworth, Kevin J (2016. ) Scavenging dissolved oxygen via acoustic droplet vaporization.Ultrasonics sonochemistry, , 31 ,394-403 More Information

Mercado, Karla P; Radhakrishnan, Kirthi; Stewart, Kyle; Snider, Lindsay; Ryan, Devin; Haworth, Kevin J (2016. ) Size-isolation of ultrasound-mediated phase change perfluorocarbon droplets using differential centrifugation.The Journal of the Acoustical Society of America, , 139 (5 ) ,EL142 More Information

Haworth, Kevin J; Raymond, Jason L; Radhakrishnan, Kirthi; Moody, Melanie R; Huang, Shao-Ling; Peng, Tao; Shekhar, Himanshu; Klegerman, Melvin E; Kim, Hyunggun; McPherson, David D; Holland, Christy K (2016. ) Erratum to: "Trans-stent B-mode Ultrasound and Passive Cavitation Imaging" in Ultrasound Med Biol 2016;42(2):518-527.Ultrasound in medicine & biology, , 42 (5 ) ,1244 More Information

Klegerman, Melvin E; Naji, Ali K; Haworth, Kevin J; Zou, Yuejiao; Golunski, Eva; Peng, Tao; Britton, George L; Huang, Shao-Ling; Holland, Christy K; McPherson, David D (2016. ) Ultrasound-enhanced bevacizumab release from echogenic liposomes for inhibition of atheroma progression.Journal of liposome research, , 26 (1 ) ,47-56 More Information

Haworth, Kevin J; Bader, Kenneth B; Rich, Kyle T; Holland, Christy K; Mast, T Douglas (2017. ) Quantitative Frequency-Domain Passive Cavitation Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control, , 64 (1 ) ,177-191 More Information

Bader, Kenneth B; Haworth, Kevin J; Maxwell, Adam D; Holland, Christy K (2018. ) Post Hoc Analysis of Passive Cavitation Imaging for Classification of Histotripsy-Induced Liquefaction in Vitro.IEEE transactions on medical imaging, , 37 (1 ) ,106-115 More Information

Kripfgans O.D.;Haworth K.J.;Steele D.D.;Swanson S.D. (08-25-2005. ) Magnetic resonance elastography using time reversed acoustics.Progress in Biomedical Optics and Imaging - Proceedings of SPIE, , 5746 (I ) ,323-332 More Information

Fabiilli M.L.;Haworth K.J.;Kripfgans O.D.;Carson P.L.;Fowlkes J.B. (12-01-2008. ) The role of inertial cavitation in acoustic droplet Vaporization.Proceedings - IEEE Ultrasonics Symposium, , 768-771 More Information

Haworth K.;Kripfgans O. (12-01-2008. ) Initial growth and coalescence of acoustically vaporized perfluorocarbon microdroplets.Proceedings - IEEE Ultrasonics Symposium, , 623-626 More Information

Haworth K.;Fabiilli M.;Fowlkes J.;Zhang M.;Kripfgans O.;Roberts W.;Carson P. (12-01-2008. ) Mean echo power as a measure of flow reduction for bubble occlusion therapy.Proceedings - IEEE Ultrasonics Symposium, , 776-779 More Information

Fabiilli M.L.;Sebastian I.E.;Haworth K.J.;Kripfgans O.D.;Carson P.L.;Fowlkes J.B. (12-01-2009. ) Ultrasonic delivery of a chemotherapeutic agent using Acoustic Droplet Vaporization (ADV).Proceedings - IEEE Ultrasonics Symposium, , More Information

Haworth K.J.;Fowlkes J.B.;Carson P.L.;Kripfgans O.D. (05-01-2010. ) Erratum: Generalized shot noise model for time-reversal in multiple-scattering media allowing for ar.Journal of the Acoustical Society of America, , 127 (5 ) ,3273 More Information

Haworth K.;Salgaonkar V.;Corregan N.;Holland C.;Mast T. (06-19-2013. ) Spatial specificity and sensitivity of passive cavitation imaging for monitoring high-intensity focu.Proceedings of Meetings on Acoustics, , 19 , More Information

Haworth K.;Raymond J.;Radhakrishnan K.;Moody M.;Huang S.;Peng T.;Shekhar H.;Klegerman M.;Kim H.;McPherson D.;Holland C. (05-01-2016. ) Erratum to: "Trans-stent B-mode Ultrasound and Passive Cavitation Imaging" in Ultrasound Med Biol 20.Ultrasound in Medicine and Biology, , 42 (5 ) ,1244 More Information

Schulz M.;Hou G.;Ng V.;Rabiee M.;Cahay M.;Chaudhary S.;Lindley D.;Chauhan D.;Paine M.;Vijayakumar D.;Xu C.;Yin Z.;Haworth K.;Liu Y.;Sundaram M.;Li W.;Mast D.;Shanov V. (01-01-2017. ) Science to commercialization of carbon nanotube sheet and yarn .WSEAS Transactions on Applied and Theoretical Mechanics, , 12 ,41-50

Fabiilli M.;Haworth K.;Zhang M.;Fowlkes J.;Kripfgans O.;Roberts W.;Ives K.;Carson P. (01-01-2008. ) SU?GG?J?196: Vascular Occlusion by Acoustically Vaporized Droplets for Potential Targeted Enhancemen.Medical Physics, , 35 (6 ) ,2724-2725 More Information

Zhang M.;Haworth K.;Swanson S.;Fabiilli M.;Kripfgans O.;Carson P.;Fowlkes J. (01-01-2009. ) WE?E?304A?05: Acoustic Droplet Vaporization for Enhancement of High Intensity Focused Ultrasound The.Medical Physics, , 36 (6 ) ,2786-2787 More Information

Haworth K.;Goldstein B.;Mercado-Shekhar K.;Holland C.;Redington A. (10-31-2017. ) Dissolved oxygen scavenging by acoustic droplet vaporization using intravascular ultrasound.IEEE International Ultrasonics Symposium, IUS, , More Information

Haworth K.J.;Arunkumar P.;Goldstein B.H.;Su H.;Mercado-Shekhar K.P.;Privitera E.M.;Srivastava R.;Holland C.K.;Redington A.N. (10-31-2017. ) Dissolved oxygen scavenging by acoustic droplet vaporization using intravascular ultrasound.IEEE International Ultrasonics Symposium, IUS, , More Information

Abadi S.H.;Haworth K.J.;Mercado-Shekhar K.P.;Dowling D.R. (07-01-2018. ) Frequency-sum beamforming for passive cavitation imaging.Journal of the Acoustical Society of America, , 144 (1 ) ,198-209 More Information

Mercado-Shekhar K.P.;Kleven R.T.;Aponte Rivera H.;Lewis R.;Karani K.B.;Vos H.J.;Abruzzo T.A.;Haworth K.J.;Holland C.K. (12-01-2018. ) Effect of Clot Stiffness on Recombinant Tissue Plasminogen Activator Lytic Susceptibility in Vitro.Ultrasound in Medicine and Biology, , 44 (12 ) ,2710-2727 More Information

Nguyen K.;Pan H.Y.;Haworth K.;Mahoney E.;Mercado-Shekhar K.P.;Lin C.Y.;Zhang Z.;C. Park Y. (01-01-2019. ) Multiple-Exposure Drug Release from Stable Nanodroplets by High-Intensity Focused Ultrasound for a P.Ultrasound in Medicine and Biology, , 45 (1 ) ,160-169 More Information

Mercado-Shekhar K.P.;Su H.;Kalaikadal D.S.;Lorenz J.N.;Manglik R.M.;Holland C.K.;Redington A.N.;Haworth K.J. (09-01-2019. ) Acoustic droplet vaporization-mediated dissolved oxygen scavenging in blood-mimicking fluids, plasma.Ultrasonics Sonochemistry, , 56 ,114-124 More Information

Mercado-Shekhar K.P.;Kleven R.;Rivera H.A.;Lewis R.;Karani K.B.;Vos H.J.;Abruzzo T.A.;Haworth K.J.;Holland C.K. (07-01-2019. ) Erratum to ‘Effect of clot stiffness on recombinant tissue plasminogen activator lytic susceptibilit.Ultrasound in Medicine and Biology, , 45 (7 ) ,1860 More Information

Shekhar H.;Palaniappan A.;Peng T.;Lafond M.;Moody M.R.;Haworth K.J.;Huang S.;McPherson D.D.;Holland C.K. (01-01-2019. ) Characterization and Imaging of Lipid-Shelled Microbubbles for Ultrasound-Triggered Release of Xenon.Neurotherapeutics, , More Information

Bollen, Viktor; Hendley, Samuel A; Paul, Jonathan D; Maxwell, Adam D; Haworth, Kevin J; Holland, Christy K; Bader, Kenneth B (2020. ) In Vitro Thrombolytic Efficacy of Single- and Five-Cycle Histotripsy Pulses and rt-PA.Ultrasound in medicine & biology, , 46 (2 ) ,336-349 More Information

Kee, Patrick H; Moody, Melanie R; Huang, Shao-Ling; Kim, Hyunggun; Yin, Xing; Peng, Tao; Laing, Susan T; Klegerman, Melvin E; Rahbar, Mohammad H; Vela, Deborah; Genstler, Curtis; Haworth, Kevin J; Holland, Christy K; McPherson, David D (2020. ) Stabilizing Peri-Stent Restenosis Using a Novel Therapeutic Carrier.JACC. Basic to translational science, , 5 (1 ) ,1-11 More Information

Kleven, Robert T; Karani, Kunal B; Salido, Nuria G; Shekhar, Himanshu; Haworth, Kevin J; Mast, T Douglas; Tadesse, Dawit G; Holland, Christy K (2019. ) The effect of 220?kHz insonation scheme on rt-PA thrombolytic efficacy in vitro.Physics in medicine and biology, , 64 (16 ) ,165015 More Information

Haworth, Kevin J; Goldstein, Bryan H; Mercado-Shekhar, Karla P; Srivastava, Rohan; Arunkumar, P; Su, Haili; Privitera, Ellena M; Holland, Christy K; Redington, Andrew N (2017. ) Dissolved Oxygen Scavenging by Acoustic Droplet Vaporization using Intravascular Ultrasound.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium, , 2017 , More Information

Lafond, Maxime; Salido, Nuria G; Haworth, Kevin J; Hannah, Alexander S; Macke, Gregory P; Genstler, Curtis; Holland, Christy K (2021. ) Cavitation Emissions Nucleated by Definity Infused through an EkoSonic Catheter in a Flow Phantom.Ultrasound in medicine & biology, , 47 (3 ) ,693-709 More Information

Hendley, Samuel A; Paul, Jonathan D; Maxwell, Adam D; Haworth, Kevin J; Holland, Christy K; Bader, Kenneth B (2021. ) Clot degradation under the action of histotripsy bubble activity and a lytic drug.IEEE transactions on ultrasonics, ferroelectrics, and frequency control, , PP , More Information

Maxwell, Adam D; Haworth, Kevin J; Holland, Christy K; Hendley, Samuel A; Kreider, Wayne; Bader, Kenneth B (2021. ) Design and Characterization of an Ultrasound Transducer for Combined Histotripsy-Thrombolytic Therapy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control, , PP , More Information

Suarez Escudero, Daniel; Haworth, Kevin J; Genstler, Curtis; Holland, Christy K (2023. ) Quantifying the Effect of Acoustic Parameters on Temporal and Spatial Cavitation Activity: Gauging Cavitation Dose.Ultrasound in medicine & biology, , 49 (11 ) ,2388-2397 More Information

Haworth, Kevin J; Niederhausen, Kelly C; Smith, Eric P; Sadayappan, Sakthivel; Wess, Yolanda; Rubinstein, Jack; Schauer, Daniel P; Soleimani, Manoocher; Rouan, Gregory W; Fichtenbaum, Carl J (2023. ) Research Initiative Supporting Excellence at the University of Cincinnati (RISE-UC): A Program to Develop and Support Research-Active Faculty Members.Academic medicine : journal of the Association of American Medical Colleges, , 98 (10 ) ,1120-1130 More Information

Haworth, Kevin J; Salido, Nuria Gonzales; Lafond, Maxime; Escudero, Daniel Suarez; Holland, Christy K (2023. ) Passive Cavitation Imaging Artifact Reduction Using Data-Adaptive Spatial Filtering.IEEE transactions on ultrasonics, ferroelectrics, and frequency control, , 70 (6 ) ,498-509 More Information

Rao, Rohan; Patel, Anjali; Hanchate, Kunal; Robinson, Eric; Edwards, Aniela; Shah, Sanjit; Higgins, Dominique; Haworth, Kevin J; Lucke-Wold, Brandon; Pomeranz Krummel, Daniel; Sengupta, Soma (2023. ) Advances in Focused Ultrasound for the Treatment of Brain Tumors.Tomography (Ann Arbor, Mich.), , 9 (3 ) ,1094-1109 More Information

Kennedy, Sonya R; Lafond, Maxime; Haworth, Kevin J; Escudero, Daniel Suarez; Ionascu, Dan; Frierson, Brion; Huang, Shaoling; Klegerman, Melvin E; Peng, Tao; McPherson, David D; Genstler, Curtis; Holland, Christy K (2023. ) Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter.Scientific reports, , 13 (1 ) ,6191 More Information

Escudero, Daniel Suarez; Lafond, Maxime; Salido, Nuria G; Haworth, Kevin J; Hannah, Alexander S; Macke, Gregory P; Genstler, Curtis; Holland, Christy K (2023. ) Corrigendum to 'Cavitation emissions nucleated by Definity infused through an EkoSonic catheter in a flow phantom' [Ultrasound in Med & Biol. 47 (2021) 693-709].Ultrasound in medicine & biology, , 49 (1 ) ,410-414 More Information

Klegerman, Melvin E; Moody, Melanie R; Huang, Shao-Ling; Peng, Tao; Laing, Susan T; Govindarajan, Vijay; Danila, Delia; Tahanan, Amirali; Rahbar, Mohammad H; Vela, Deborah; Genstler, Curtis; Haworth, Kevin J; Holland, Christy K; McPherson, David D; Kee, Patrick H (2023. ) Demonstration of ultrasound-mediated therapeutic delivery of fibrin-targeted pioglitazone-loaded echogenic liposomes into the arterial bed for attenuation of peri-stent restenosis.Journal of drug targeting, , 31 (1 ) ,109-118 More Information

Benton, Rachel P; Al Rifai, Nour; Stone, Kateryna; Clark, Abigail; Zhang, Bin; Haworth, Kevin J (2022. ) Impact of Perfluoropentane Microdroplets Diameter and Concentration on Acoustic Droplet Vaporization Transition Efficiency and Oxygen Scavenging.Pharmaceutics, , 14 (11 ) , More Information

Zemzemi, Chadi; Phillips, Matthew; Vela, Deborah C; Hilvert, Nicole A; Racadio, John M; Bader, Kenneth B; Haworth, Kevin J; Holland, Christy K (2022. ) Effect of Thrombin and Incubation Time on Porcine Whole Blood Clot Elasticity and Recombinant Tissue Plasminogen Activator Susceptibility.Ultrasound in medicine & biology, , 48 (8 ) ,1567-1578 More Information

Lechpammer, Mirna; Rao, Rohan; Shah, Sanjit; Mirheydari, Mona; Bhattacharya, Debanjan; Koehler, Abigail; Toukam, Donatien Kamdem; Haworth, Kevin J; Pomeranz Krummel, Daniel; Sengupta, Soma (2022. ) Advances in Immunotherapy for the Treatment of Adult Glioblastoma: Overcoming Chemical and Physical Barriers.Cancers, , 14 (7 ) , More Information

Mercado-Shekhar, Karla P; Su, Haili; Kalaikadal, Deepak S; Lorenz, John N; Manglik, Raj M; Holland, Christy K; Redington, Andrew N; Haworth, Kevin J (2019. ) Acoustic droplet vaporization-mediated dissolved oxygen scavenging in blood-mimicking fluids, plasma, and blood.Ultrasonics sonochemistry, , 56 ,114-124 More Information

Mercado-Shekhar, Karla P; Kleven, Robert; Rivera, Hermes Aponte; Lewis, Ryden; Karani, Kunal B; Vos, Hendrik J; Abruzzo, Todd A; Haworth, Kevin J; Holland, Christy K (2019. ) Erratum to 'Effect of clot stiffness on recombinant tissue plasminogen activator lytic susceptibility in vitro' [Ultrasound Med Biol 44 (2018) 2710-2727].Ultrasound in medicine & biology, , 45 (7 ) ,1860 More Information

Shekhar, Himanshu; Palaniappan, Arunkumar; Peng, Tao; Lafond, Maxime; Moody, Melanie R; Haworth, Kevin J; Huang, Shaoling; McPherson, David D; Holland, Christy K (2019. ) Characterization and Imaging of Lipid-Shelled Microbubbles for Ultrasound-Triggered Release of Xenon.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , 16 (3 ) ,878-890 More Information

Mercado-Shekhar, Karla P; Kleven, Robert T; Aponte Rivera, Hermes; Lewis, Ryden; Karani, Kunal B; Vos, Hendrik J; Abruzzo, Todd A; Haworth, Kevin J; Holland, Christy K (2018. ) Effect of Clot Stiffness on Recombinant Tissue Plasminogen Activator Lytic Susceptibility in Vitro.Ultrasound in medicine & biology, , 44 (12 ) ,2710-2727 More Information

Abadi, Shima H; Haworth, Kevin J; Mercado-Shekhar, Karla P; Dowling, David R (2018. ) Frequency-sum beamforming for passive cavitation imaging.The Journal of the Acoustical Society of America, , 144 (1 ) ,198 More Information

Invited Publications

Fischesser, Demetria M; Bo, Bin; Benton, Rachel P; Su, Haili; Jahanpanah, Newsha; Haworth, Kevin J (2021. ) Controlling Reperfusion Injury With Controlled Reperfusion: Historical Perspectives and New Paradigms.Journal of cardiovascular pharmacology and therapeutics, 10742484211046674 More Information

Invited Presentations

Haworth, Kevin J (10-09-2012. ) Arrays and Microbubbles in Medical Ultrasound Applications .University of Mississippi, Department of Physics.

Haworth, Kevin J (02-27-2012. ) Ultrasound-Mediated Microbubble Bioeffects: Production, Induction, and Optimization .Boston University, Department of Mechanical Engineering.

Haworth, Kevin J (04-06-2011. ) Passive Cavitation Imaging for Ultrasound Therapies .University of California-Riverside, Department of Mechanical Engineering.

Haworth, Kevin J (02-23-2011. ) Passive Cavitation Imaging: a New Technique for Optimization and Guid- ance of Microbubble-Based Ultrasound Therapies .Vanderbilt University Institute of Imaging Science.

Haworth, Kevin J (09-24-2010. ) The Importance of the When and Where of Cavitation .University of Michigan, Basic Radiological Sciences Division.

Haworth, Kevin J (02-27-2009. ) Acoustic Droplet Vaporization and Ultrasonic Aberration Correction .University of Cincinnati, Department of Biomedical Engineering.

Haworth, Kevin J (03-06-2009. ) Acoustic Droplet Vaporization and Ultrasonic Aberration Correction .University of Oxford, Biomedical Ultrasonics and Biotherapy Laboratory.

Kevin J. Haworth (11-18-2014. ) The case of the Missing Oxygen .Cardiovascular Health and Disease Grand Rounds, University of Cincinnati, Cincinnati, OH.

Kevin J. Haworth (11-20-2014. ) From Clots to Microbubbles to Imaging and Back .Heart, Lung and Vascular Institutes Seminar Series, University of Cincinnati, Cincinnati, OH.

Kevin J. Haworth (06-11-2015. ) Ultrasound-mediated Oxygen Scavenging .Wayne State University, Detroit, MI.

Kevin J. Haworth (03-25-2016. ) That's not my Hypothesis: Ultrasound Mediated Oxygen Scavenging .Cincinnati Center for Clinical and Translational Science and Training Grand Rounds, Cincinnati, OH.

Kevin J. Haworth (09-29-2016. ) The Case of the Missing Oxygen (and Other Adventures in Ultrasound) .Bioengineering Seminar Series, University of Louisville, Louisville, KY.

Colloquium

Kevin J. Haworth (10-09-2012). Arrays and microbubbles in Medical Ultrasound Applications .University of Mississippi.

Kevin J. Haworth (02-27-2012). Ultrasound-Medicated Microbubble Bioeffects: Production, Induction, and Optimization .Boston University.

Kevin J. Haworth (04-06-2011). Passive Cavitation Imaging for Ultrasound Therapies .University of California - Riverside.

Kevin J. Haworth (02-23-2011). Passive Cavitation Imaging: a New Technique for Optimization and Guidance of Microbubble-Based Ultrasound Therapies .Vanderbilt University.

Kevin J. Haworth (09-24-2010). The Importance of the When and Where of Cavitation .University of Science.

Kevin J. Haworth (02-27-2009). Acoustic Droplet Vaporization and Ultrasonic Aberration Correction .University of Cincinnati.

Kevin J. Haworth (03-06-2009). Acoustic Droplet Vaporization and Ultrasonic Aberration Correction .University of Oxford.

2013 International Congress on Acoustics Young Scientist Conference Award International Congress on Acoustics Status:Recipient Level:International Type:Recognition

2008 IEEE Ultrasonics Symposium Student Travel Grant Status:Recipient Level:International Type:Recognition

2008 Travel Grant Awardee Office of Naval Research Status:Recipient Level:National Type:Recognition

2005 -2008 Travel Grant Awardee University of Michigan Rackham Graduate School Status:Recipient Level:University Type:Recognition

2008 Physical Acoustics Summer School Scholarship Recipient Status:Recipient Level:National Type:Recognition

2005 Preliminary Exam - Pass with Distinction University of Michigan Applied Physics Program Status:Recipient Level:Department Type:Recognition

2003 -2005 Applied Physics Fellow University of Michigan Applied Physics Program Status:Recipient Level:Department Type:Fellowship

2003 -2004 Graduate Fellowship Phi Kappa Phi Status:Recipient Level:National Type:Fellowship

2003 -To Present Member Phi Beta Kappa

2002 -To Present Member Phi Kappa Phi

2001 -To Present Member Sigma Pi Sigma

2001 -2003 Barry M. Goldwater Scholar Barry M. Goldwater Foundation Status:Recipient Level:National Type:Fellowship

2020 Senior Membership Elevated to senior membership in IEEE, the largest professional engineering society in the world. Senior members represent 8% of the entire membership. IEEE Status:Recipient Level:International Type:Recognition

2020 Gratitude Award UC College of Medicine Status:Recipient Level:College Type:Recognition

2019 Frederic Lizzi Early Career Award Awarded annually to individuals who have made outstanding early career (within 10 years of terminal degree) contributions to the field of therapeutic ultrasound. International Society for Therapeutic ultrasound Status:Recipient Level:International Type:Recognition

2019 Outstanding Mentor Donald T. Scholars Program at the University of Cincinnati Status:Recipient Level:University Type:Recognition

2018 Early-career Travel Award Acoustical Society of America Status:Recipient Level:National Type:Recognition

2017 Early-career Travel Award Acoustical Society of America Status:Recipient Level:National Type:Monetary

2016 Early-career Acousticians Retreat Award Selected to participate in an Early-career retreat, including partial reimbursement of expenses for travel, housing, and food during the retreat. Acoustical Society of America Status:Recipient Level:National Type:Recognition

2020 Fellow American Institute of Ultrasound in Medicine Status:Recipient Level:National Type:Fellowship

2021 UC Sigma Xi Young Investigator Award This annual award, presented in conjunction with the Office of the Vice President for Research, recognizes a junior faculty member at UC for their early career distinguished research accomplished in a field of science or engineering appropriate to Sigma Xi. Nominees do not need to be members of Sigma X UC Chapter of Sigma Xi Status:Recipient Level:Local Type:Recognition

2022 Outstanding Teacher of the Year, Runner-up Was voted 2nd place by the students of the Pathobiology and Molecular Medicine Graduate Program as the most outstanding teacher. UC Pathobiology and Molecular Medicine Graduate Program Status:Recipient Level:Department Type:Recognition

-2022 Excellence in Undergraduate Research Mentorship Award Was student-nominated and selected by the UC Office of Undergraduate Research for excellence in mentoring undergraduates performing research. UC Office of Undergraduate Research Status:Recipient Level:University Type:Recognition

-2023 Presidential Recognition Award Was a co-recipient with other member of the Ultracon 2023 Symposium Design Workshop team for the AIUM's Presidential Recognition Award. American Institute of Ultrasound in Medicine Status:Recipient Level:National Type:Recognition

-2022 Fellowship in the Acoustical Society of America Elected a fellow of the Acoustical Society of America for "contributions to the development of passive cavitation imaging and therapeutic ultrasound methods." Acoustical Society of America Status:Recipient Level:National Type:Fellowship

Internal Medicine (Workload Document Taskforce ) Committee Chair Type:Departmental Service Level:Department 2013 -2014

University of Cincinnati (New Faculty Orientation ) Other Type:University/College Service Level:University 2013

College of Medicine (Research Culture & Marketing Committee ) Committee Member Type:University/College Service Level:College 2012

Internal Medicine Judge Type:Departmental Service Level:Department

College of Medicine Judge Type:University/College Service Level:College 2010 -To Present

College of Medicine Judge Type:University/College Service Level:College 2009 -2013

Ultrasound in Medicine and Biology Editorial Board Member Type:Editorial Service Level:International 2013 -To Present

Ultrasound in Medicine and Biology Peer Review/Referee Type:Editorial Service Level:International 2009 -To Present

Journal of the Acoustical Society of America Peer Review/Referee Type:Editorial Service Level:National 2010 -To Present

Journal of Ultrasound in Medicine Peer Review/Referee Type:Editorial Service Level:National 2011 -To Present

Medical Physics Peer Review/Referee Type:Editorial Service Level:National 2012 -To Present

Physics in Medicine and Biology Peer Review/Referee Type:Editorial Service Level:International 2012 -To Present

Journal of Drug Delivery Science and Technology Peer Review/Referee Type:Editorial Service Level:National 2012

Internal Medicine - Cardiovascular Health and Disease Type:Departmental Service Level:Department

ultrasound, cavitation, imaging, signal processing, reperfusion injury, beamforming

2014: Scholarship Selection Review Committee Barry M. Goldwater Scholarship and Excellence in Education Foundation,

2010 -To Present: Biomedical Acoustics Student Paper Award Committee Chairman Acoustical Society of America,

2011 -2014: Biomedical Acoustics Technical Committee Member Acoustical Society of America,

2011 -2012: Reviewer (Grant) North Carolina Biotechnology Centers,

2013: Reviewer (Grant) Oak Ridge Associated University - Nazarbayev University Program,

2011 -To Present: Member American Heart Association,

2009 -To Present: Member American Institute of Ultrasound in Medicine,

2005 -To Present: Member Student Member 2005-2009; Associate Member 2009-2013; Full Member 2013 to present IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society,

2005 -To Present: Member Student Member 2005-2009; Associate Member: 2009-2013; Full Member: 2013 to present Acoustical Society of America,

2003 -To Present: Member Associate Member: 2003-2009; Full Member: 2009 to present Sigma Xi,

2000 -2003: Physics Tutor Truman State University

2004 -2008: Private Mathematics and Physics Tutor

-BME-2000C BME IN THE CLINIC Level:Undergraduate

-BME-2000C BME IN THE CLINIC Level:Undergraduate

Medical Sciences Junior Seminar Level:Undergraduate

Medical Imaging: Science and Application Level:Undergraduate

-GNTD-8003 CAREER OPP BIOM SCI Level:Graduate

US Patent 9,675,820 Ultrasound-Mediated Inducement, Detection, and Enhancement of Stable Cavi- tation Christy K. Holland, Saurabh Datta, T. Douglas Mast, Nikolas Ivancevich, Kathryn E. Hitchcock, and Kevin J. Haworth, Awarded 06-13-2021 Co-Inventor

US Patent 9,669,203 Methods of Enhancing Delivery of Drugs Using Ultrasonic Waves and Systems for Performing The Same Christy K. Holland, Kathryn E. Hitchcock, Kevin J. Haworth, Nikolas M. Ivancevich, and T. Douglas Mast, Awarded 06-06-2017 Co-Inventor

US Patent 10,688,039 Scavenging Dissolved Oxygen via Acoustic Droplet Vaporization Kirthi Radhakrishnan, Christy K. Holland, Kevin J. Haworth, Awarded 06-23-2020 Inventor

16/614,584 Intravascular Ultrasound Device and Methods for Avoiding or Treating Reperfusion Injury Kevin J. Haworth, Christy K. Holland, Karla Mercado-Shekhar, Andrew Redington, Bryan Goldstein, Filed Inventor

63/047,494 3-D Cavitation Activity Display and Duplex Method with B-mode Ultrasound Images Maxime Lafond, Kevin J. Haworth, Nuria G. Salido, Christy K. Holland, Filed Co-Inventor

Research - Cardiovascular Center, 3939
231 Albert Sabin Way
Cincinnati  Ohio, 45267-0586
Phone: 513-558-3536
Fax: 513-558-6102
kevin.haworth@uc.edu