Judith A Heiny , PhD

Biomedical Research
Graduate Education
Medical Education
Departmental Service

Doctoral Degree: University of Cincinnati Ohio, 1980 (Biophysics)

Postdoctoral Fellowship: University of California Los Angeles Los Angeles , CA , 1984 (Physiology)

Research in our laboratory focuses on the Na,K-ATPase in skeletal muscle. We are currently investigating the physiological roles of the Na,K-ATPase alpha isoforms in muscle, and the physiological roles of cardiotonic steroids in their regulation

Grant: #NIH-1S10R027743-01 Investigators:J. Hove, P.I 05-13-2010 -05-12-2011 Zeiss LSM 7 Duo Subproject 4: J. A. Heiny and Jerry B Lingrel “Role of local blood flow in contracting skeletal muscle by the cardiotonic steroid receptor of the Na,K-ATPase. 05/13/2010 – 05/12/2011 Role:Co-Investigator Pending Type:Grant

Grant: #NIH 1-R21HL114284-01 Investigators:J. Heiny 12-01-2012 -11-30-2014 NIH Endogenous Cardiotonic Hormones in Kidney Disease and Hypertension Role:PI $275,000. Active Type:Grant Level:National

Grant: #R21 HL114284 Investigators:Heiny, Judith 02-01-2013 -01-31-2015 National Heart, Lung and Blood Institute Endogenous Cardiotonic Hormones in Kidney Disease and Hypertension Role:PI $237,000.00 Active Level:Federal

Grant: #R01AR063710 Investigators:Heiny, Judith; Lingrel, Jerry 09-01-2013 -08-31-2018 National Institute of Arthritis, Musculoskeletal and Skin Disease Isoform-specific roles of the Na,K-ATPase in skeletal muscle Role:PI $429,833.00 Active Level:Federal

Grant: #R01AR078001 Investigators:Heiny, Judith; Lorenz, John; Sadayappan, Sakthivel 08-15-2020 -07-31-2025 National Institute of Arthritis, Musculoskeletal and Skin Disease Slow myosin binding protein-C in skeletal muscle physiology Role:Collaborator $453,512.00 Active Level:Federal

Grant: #F31DK132940 Investigators:Heiny, Judith; Norman, Natalie 04-01-2022 -03-31-2024 National Inst of Diabetes and Digestive and Kidney Disease An exercise driven, insulin independent glucose uptake pathway in contracting skeletal muscle Role:PI 43448.00 Awarded Level:Federal

Published Abstracts

Judith A. Heiny, Violetta V. Kravtsova, Frederic Mandel, Tatiana L. Radzyukevich, Boubacar Benziane, Alexander V. Prokofiev, Alexander V. Chibalin, and Igor I. Krivoi. The Nicotinic Acetylcholine Receptor and the Na,K-ATPase 2 Isoform Interact at the Neuromuscular Junction to Regulate Membrane Electrogenesis.

Peer Reviewed Publications

Radzyukevich, T L; Lingrel, J B; Heiny, J A (2009. ) The cardiac glycoside binding site on the Na,K-ATPase alpha2 isoform plays a role in the dynamic regulation of active transport in skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America, , 106 (8 ) ,2565-70 More Information

Radzyukevich, Tatiana L; Heiny, Judith A (2004. ) Regulation of dihydropyridine receptor gene expression in mouse skeletal muscles by stretch and disuse.American journal of physiology. Cell physiology, , 287 (5 ) ,C1445-52 More Information

Radzyukevich, Tatiana L; Moseley, Amy E; Shelly, Daniel A; Redden, Gregory A; Behbehani, Michael M; Lingrel, Jerry B; Paul, Richard J; Heiny, Judith A (2004. ) The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm.American journal of physiology. Cell physiology, , 287 (5 ) ,C1300-10 More Information

Radzyukevich, Tatiana L; Cougnon, Marc H; Moseley, Amy E; Heiny, Judith A (2004. ) Developmental induction of DHPR alpha 1s and RYR1 gene expression does not require neural or mechanical signals. Journal of muscle research and cell motility, , 25 (1 ) ,87-94

Cougnon, Marc H; Moseley, Amy E; Radzyukevich, Tatiana L; Lingrel, Jerry B; Heiny, Judith A (2002. ) Na,K-ATPase alpha- and beta-isoform expression in developing skeletal muscles: alpha(2) correlates with t-tubule formation.Pflügers Archiv : European journal of physiology, , 445 (1 ) ,123-31 More Information

Jong, D S; Stroffekova, K; Heiny, J A (1997. ) A surface potential change in the membranes of frog skeletal muscle is associated with excitation-contraction coupling. The Journal of physiology, , 499 ( Pt 3) ,787-808

Stroffekova, K; Heiny, J A (1997. ) Stimulation-dependent redistribution of charge movement between unavailable and available states. General physiology and biophysics, , 16 (1 ) ,79-89

Stroffekova, K; Heiny, J A (1997. ) Triadic Ca2+ modulates charge movement in skeletal muscle. General physiology and biophysics, , 16 (1 ) ,59-77

Masaki, H; Green, S A; Heiny, J A; Yatani, A (1995. ) Beta 2-adrenergic receptor regulation of the cardiac L-type Ca2+ channel coexpressed in a fibroblast cell line. Receptor, , 5 (4 ) ,219-31

Kokate, T G; Heiny, J A; Sperelakis, N (1993. ) Stimulation of the slow calcium current in bullfrog skeletal muscle fibers by cAMP and cGMP. The American journal of physiology, , 265 (1 Pt 1 ) ,C47-53

Heiny, J A; Valle, J R; Bryant, S H (1990. ) Optical evidence for a chloride conductance in the T-system of frog skeletal muscle. Pflügers Archiv : European journal of physiology, , 416 (3 ) ,288-95

Heiny, J A; Jong, D; Bryant, S H; Conte-Camerino, D; Tortorella, V (1990. ) Enantiomeric effects on excitation-contraction coupling in frog skeletal muscle by a chiral phenoxy carboxylic acid.Biophysical journal, , 57 (1 ) ,147-52 More Information

Heiny, J A; Jong, D S (1990. ) A nonlinear electrostatic potential change in the T-system of skeletal muscle detected under passive recording conditions using potentiometric dyes. The Journal of general physiology, , 95 (1 ) ,147-75

Ashcroft, F M; Heiny, J A; Vergara, J (1985. ) Inward rectification in the transverse tubular system of frog skeletal muscle studied with potentiometric dyes. The Journal of physiology, , 359 ,269-91

Heiny, J A; Vergara, J (1984. ) Dichroic behavior of the absorbance signals from dyes NK2367 and WW375 in skeletal muscle fibers. The Journal of general physiology, , 84 (5 ) ,805-37

Heiny, J A; Ashcroft, F M; Vergara, J (1983. ) T-system optical signals associated with inward rectification in skeletal muscle. Nature, , 301 (5896 ) ,164-6

Heiny, J A; Vergara, J (1982. ) Optical signals from surface and T system membranes in skeletal muscle fibers. Experiments with the potentiometric dye NK2367. The Journal of general physiology, , 80 (2 ) ,203-30

Camerino, C; Zayzafoon, M; Rymaszewski, M; Heiny, J; Rios, M; Hauschka, P V (2012. ) Central depletion of brain-derived neurotrophic factor in mice results in high bone mass and metabolic phenotype.Endocrinology, , 153 (11 ) ,5394-405 More Information

Chibalin, Alexander V; Heiny, Judith A; Benziane, Boubacar; Prokofiev, Alexander V; Vasiliev, Alexander V; Kravtsova, Violetta V; Krivoi, Igor I (2012. ) Chronic nicotine modifies skeletal muscle Na,K-ATPase activity through its interaction with the nicotinic acetylcholine receptor and phospholemman.PloS one, , 7 (3 ) ,e33719 More Information

Heiny, Judith A (2010. ) S100A1: a physiological modulator of RYR1, Ca2+ release, and contractility in skeletal muscle. Focus on "S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle".American journal of physiology. Cell physiology, , 299 (5 ) ,C882-4 More Information

Heiny, Judith A; Kravtsova, Violetta V; Mandel, Frederic; Radzyukevich, Tatiana L; Benziane, Boubacar; Prokofiev, Alexander V; Pedersen, Steen E; Chibalin, Alexander V; Krivoi, Igor I (2010. ) The nicotinic acetylcholine receptor and the Na,K-ATPase alpha2 isoform interact to regulate membrane electrogenesis in skeletal muscle.The Journal of biological chemistry, , 285 (37 ) ,28614-26 More Information

Heiny, J S; Tate, C M (1997. ) Concentration, distribution, and comparison of selected trace elements in bed sediment and fish tissue in the South Platte River Basin, USA, 1992-1993. Archives of environmental contamination and toxicology, , 32 (3 ) ,246-59

Yamamoto, S; Askew, G R; Heiny, J; Masaki, H; Yatani, A (1996. ) Modulation of pump function by mutations in the first transmembrane region of Na(+)-K(+)-ATPase alpha 1-subunit. The American journal of physiology, , 270 (2 Pt 1 ) ,C457-64

Moczydlowski, E; Uehara, A; Guo, X; Heiny, J (1986. ) Isochannels and blocking modes of voltage-dependent sodium channels. Annals of the New York Academy of Sciences, , 479 ,269-92

De Bellis, Michela; De Luca, Annamaria; Desaphy, Jean F; Carbonara, Roberta; Heiny, Judith A; Kennedy, Ann; Carocci, Alessia; Cavalluzzi, Maria M; Lentini, Giovanni; Franchini, Carlo; Camerino, Diana Conte (2013. ) Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels.Biophysical journal, , 104 (2 ) ,344-54 More Information

Radzyukevich, Tatiana L; Neumann, Jonathon C; Rindler, Tara N; Oshiro, Naomi; Goldhamer, David J; Lingrel, Jerry B; Heiny, Judith A (2013. ) Tissue-specific role of the Na,K-ATPase ?2 isozyme in skeletal muscle.The Journal of biological chemistry, , 288 (2 ) ,1226-37 More Information

Lauf, Peter K; Heiny, Judith; Meller, Jarek; Lepera, Michael A; Koikov, Leonid; Alter, Gerald M; Brown, Thomas L; Adragna, Norma C (2013. ) Canonical Bcl-2 motifs of the Na+/K+ pump revealed by the BH3 mimetic chelerythrine: early signal transducers of apoptosis?.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 31 (2-3 ) ,257-76 More Information

Heiny, Judith (2013. ) Pumped up and pregnant.Experimental physiology, , 98 (1 ) ,48 More Information

DECKER, K; HEINY, J (1956. ) [X-ray diagnosis of cerebral metastases of hypernephroma]. Deutsche Zeitschrift für Nervenheilkunde, , 174 (2 ) ,107-22

Kravtsova, Violetta V; Matchkov, Vladimir V; Bouzinova, Elena V; Vasiliev, Alexander N; Razgovorova, Irina A; Heiny, Judith A; Krivoi, Igor I (2015. ) Isoform-specific Na,K-ATPase alterations precede disuse-induced atrophy of rat soleus muscle.BioMed research international, , 2015 ,720172 More Information

Petrov, Alexey M; Kravtsova, Violetta V; Matchkov, Vladimir V; Vasiliev, Alexander N; Zefirov, Andrey L; Chibalin, Alexander V; Heiny, Judith A; Krivoi, Igor I (2017. ) Membrane lipid rafts are disturbed in the response of rat skeletal muscle to short-term disuse.American journal of physiology. Cell physiology, , 312 (5 ) ,C627-C637 More Information

Figueroa, Julio A Landero; Stiner, Cory A; Radzyukevich, Tatiana L; Heiny, Judith A (2016. ) Metal ion transport quantified by ICP-MS in intact cells.Scientific reports, , 6 ,20551 More Information

Kravtsova, Violetta V; Petrov, Alexey M; Matchkov, Vladimir V; Bouzinova, Elena V; Vasiliev, Alexander N; Benziane, Boubacar; Zefirov, Andrey L; Chibalin, Alexander V; Heiny, Judith A; Krivoi, Igor I (2016. ) Distinct ?2 Na,K-ATPase membrane pools are differently involved in early skeletal muscle remodeling during disuse.The Journal of general physiology, , 147 (2 ) ,175-88 More Information

Manoharan, Palanikumar; Radzyukevich, Tatiana L; Hakim Javadi, Hesamedin; Stiner, Cory A; Landero Figueroa, Julio A; Lingrel, Jerry B; Heiny, Judith A (2015. ) Phospholemman is not required for the acute stimulation of Na?-K?-ATPase ??-activity during skeletal muscle fatigue.American journal of physiology. Cell physiology, , 309 (12 ) ,C813-22 More Information

DiFranco, Marino; Hakimjavadi, Hesamedin; Lingrel, Jerry B; Heiny, Judith A (2015. ) Na,K-ATPase ?2 activity in mammalian skeletal muscle T-tubules is acutely stimulated by extracellular K+.The Journal of general physiology, , 146 (4 ) ,281-94 More Information

Naticchioni, Mindi; Karani, Rajiv; Smith, Margaret A; Onusko, Evan; Robbins, Nathan; Jiang, Min; Radzyukevich, Tatiana; Fulford, Logan; Gao, Xu; Apel, Ryan; Heiny, Judith; Rubinstein, Jack; Koch, Sheryl E (2015. ) Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise.PloS one, , 10 (9 ) ,e0136901 More Information

Hakimjavadi, Hesamedin; Stiner, Cory A; Radzyukevich, Tatiana L; Lingrel, Jerry B; Norman, Natalie; Landero Figueroa, Julio A; Heiny, Judith A (2018. ) K⁺ and Rb⁺ Affinities of the Na,K-ATPase α₁ and α₂ Isozymes: An Application of ICP-MS for Quantification of Na⁺ Pump Kinetics in Myofibers.International journal of molecular sciences, , 19 (9 ) , More Information

Book Chapter

Nicholas Sperelakis, Judith Heiny, Hugo Gonzalez-Serratos (2011 ) Skeletal Muscle Excitability Cell Physiology Source Book (Fourth Edition), Essentials of Membrane Biophysics .(pp. 729 -756).Elsevier Inc (Co-Author)

Judith A. Heiny, Gerhard Meissner (2011 ) Excitation-Contraction Coupling in Skeletal Muscle Cell Physiology Source Book (Fourth Edition), Essentials of Membrane Biophysics .(pp. 783 -800).Elsevier Inc (Co-Author)

Arshani Wansapura (Doctoral ) Committee Member

Kaylyn Williamson (Undergrad ) Lab Rotation Preceptor Status:Completed 2009

Dr. Frederic Mandel (Other ) Supervisor Status:Completed 2009

(Masters In Physiology Admissions Committee ) Committee Member Type:University/College Service Level:Department 2008 -2009

(Committee on Distance Learning ) Committee Member Type:University/College Service Level:Department 2009

( ARPT Committee ) Committee Member Type:University/College Service Level:Department

(Shared Space and Facilities Committee ) Committee Member Type:University/College Service Level:Department 2005 -To Present

(Medical Education Committee ) Committee Member Type:University/College Service Level:College 1996 -To Present

NHLBI Reviewer Type:Editorial Service Level:National

J.of Appl Physiol Reviewer Type:Editorial Service Level:National

Am J Physiol Reviewer Type:Editorial Service Level:National

Adv in Medical Education, Journal of Cell Physiology and Toxicology Reviewer Type:Editorial Service Level:National

Masters in Physiology Program (AMCAS essays ) Reviewer Type:Departmental Service Level:Department

Musculoskeletal Diseases(MeSH C05),Genetic Processes(MeSH G05),Musculoskeletal

Invited talk and abstract: “The cardiac glycoside binding site on the Na,K-ATPase ?2 isoform regulates its active transport in skeletal muscle.” International P-type ATPase Conference (triennial meeting), Aug 5-10, Aarhus, Denmark. 2008

Abstract: Tatiana L. Radzyukevich, Marisa Fuse and Judith A. Heiny. “Transcriptional remodeling of mitochondrial function is an early adaptation to muscle disuse.” European Muscle Conference of the European Society for Muscle Research. Sep 13-16, 2008. Oxford, UK. Journal of Muscle Research and Cell Motility

Molecular Physiology Level:Graduate

Lecturer, General and Mammalian Physiology (Medical Physiology) Level:Graduate

Cellular Neurophysiology Module, Human Systems Biology I Level:Graduate

Research Techniques Level:Graduate

Interviewing Skills, Masters in Physiology Program Level:Graduate

Academic - Cincinnati  Ohio, 45267