Michael Helmrath

Michael Helmrath

Professor of Surgery; Director of Surgical Research and Director of Intestinal Rehabilitation Center, CCHMC

Childrens Hospital Bldg R

COM Surgery Pediatric - 0054

Cincinnati Children's Hospital Medical Center
Department of Pediatric Surgery
Cincinnati, Ohio 45229

Education

Bachelor's Degree, Miami University - Oxford 1987

Medical Degree, University of Cincinnati 1993

Master's Degree, University of Cincinnati 1989 (Physiology and Biophysics)

Research Fellow in Pediatric Surgery, Cincinnati Children's Hospital Medical Center 1997

ECMO Fellowship, Cincinnati Children's Hospital Medical Center 1997

General Surgery Residency, University of Cincinnati 2000

Fellowship in Pediatric Surgery, Baylor College of Medicine, Texas Children's Hospital of Houston 2002

Research and Practice Interests

Short Bowel Syndrome, Intestinal Stem Cell Research

Publications

Peer Reviewed Publications

Bout-Tabaku, Sharon; Michalsky, Marc P; Jenkins, Todd M; Baughcum, Amy; Zeller, Meg H; Brandt, Mary L; Courcoulas, Anita; Buncher, Ralph; Helmrath, Michael; Harmon, Carroll M; Chen, Mike K; Inge, Thomas H (2015. )Musculoskeletal Pain, Self-reported Physical Function, and Quality of Life in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Cohort.JAMA pediatrics, ,169 (6 ),552-9

Xanthakos, Stavra A; Jenkins, Todd M; Kleiner, David E; Boyce, Tawny W; Mourya, Reena; Karns, Rebekah; Brandt, Mary L; Harmon, Carroll M; Helmrath, Michael A; Michalsky, Marc P; Courcoulas, Anita P; Zeller, Meg H; Inge, Thomas H (2015. )High Prevalence of Nonalcoholic Fatty Liver Disease in Adolescents Undergoing Bariatric Surgery.Gastroenterology, ,

Michalsky, Marc P; Inge, Thomas H; Simmons, Mark; Jenkins, Todd M; Buncher, Ralph; Helmrath, Michael; Brandt, Mary L; Harmon, Carroll M; Courcoulas, Anita; Chen, Michael; Horlick, Mary; Daniels, Stephen R; Urbina, Elaine M (2015. )Cardiovascular Risk Factors in Severely Obese Adolescents: The Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Study.JAMA pediatrics, ,169 (5 ),438-44

Zeller, Meg H; Inge, Thomas H; Modi, Avani C; Jenkins, Todd M; Michalsky, Marc P; Helmrath, Michael; Courcoulas, Anita; Harmon, Carroll M; Rofey, Dana; Baughcum, Amy; Austin, Heather; Price, Karin; Xanthakos, Stavra A; Brandt, Mary L; Horlick, Mary; Buncher, Ralph (2015. )Severe obesity and comorbid condition impact on the weight-related quality of life of the adolescent patient.The Journal of pediatrics, ,166 (3 ),651-9.e4

Inge, Thomas H; Boyce, Tawny W; Lee, Margaret; Kollar, Linda; Jenkins, Todd M; Brandt, Mary L; Helmrath, Michael; Xanthakos, Stavra A; Zeller, Meg H; Harmon, Carroll M; Courcoulas, Anita; Michalsky, Marc P (2014. )Access to care for adolescents seeking weight loss surgery.Obesity (Silver Spring, Md.), ,22 (12 ),2593-7

Xiao, Nianzhou; Jenkins, Todd M; Nehus, Edward; Inge, Thomas H; Michalsky, Marc P; Harmon, Carroll M; Helmrath, Michael A; Brandt, Mary L; Courcoulas, Anita; Moxey-Mims, Marva; Mitsnefes, Mark M (2014. )Kidney function in severely obese adolescents undergoing bariatric surgery.Obesity (Silver Spring, Md.), ,22 (11 ),2319-25

Michalsky, Marc P; Inge, Thomas H; Teich, Steven; Eneli, Ihuoma; Miller, Rosemary; Brandt, Mary L; Helmrath, Michael; Harmon, Carroll M; Zeller, Meg H; Jenkins, Todd M; Courcoulas, Anita; Buncher, Ralph C (2014. )Adolescent bariatric surgery program characteristics: the Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study experience.Seminars in pediatric surgery, ,23 (1 ),5-10

Inge, Thomas H; Zeller, Meg H; Jenkins, Todd M; Helmrath, Michael; Brandt, Mary L; Michalsky, Marc P; Harmon, Carroll M; Courcoulas, Anita; Horlick, Mary; Xanthakos, Stavra A; Dolan, Larry; Mitsnefes, Mark; Barnett, Sean J; Buncher, Ralph (2014. )Perioperative outcomes of adolescents undergoing bariatric surgery: the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study.JAMA pediatrics, ,168 (1 ),47-53

Ubesie, Agozie C; Kocoshis, Samuel A; Mezoff, Adam G; Henderson, Carol J; Helmrath, Michael A; Cole, Conrad R (2013. )Multiple micronutrient deficiencies among patients with intestinal failure during and after transition to enteral nutrition.The Journal of pediatrics, ,163 (6 ),1692-6

Eradi, Balgopal; Hamrick, Miller; Bischoff, Andrea; Frischer, Jason S; Helmrath, Michael; Hall, Jennifer; Peña, Alberto; Levitt, Marc A (2013. )The role of a colon resection in combination with a Malone appendicostomy as part of a bowel management program for the treatment of fecal incontinence.Journal of pediatric surgery, ,48 (11 ),2296-300

Hamrick, Miller; Helmrath, Michael; Bischoff, Andrea; Eradi, Balgopal; Levitt, Marc; Peña, Alberto (2011. )Letter to the Editor regarding comparison of anorectal angle and continence after Georgeson and Peña procedures for high/intermediate imperforate anus.Journal of pediatric surgery, ,46 (5 ),1019-20; author repl

Dehmer, Jeffrey J; Fuller, Megan K; Helmrath, Michael A (2011. )Management of pediatric intestinal failure.Advances in pediatrics, ,58 (1 ),181-94

Inge, Thomas; Helmrath, Michael; Vierra, Mark (2010. )The Santoro III massive enterectomy: how can we justify the risks in obese adolescents?.Obesity surgery, ,20 (12 ),1718-9

Brandt, Mary L; Harmon, Carroll M; Helmrath, Michael A; Inge, Thomas H; McKay, Siripoom V; Michalsky, Marc P (2010. )Morbid obesity in pediatric diabetes mellitus: surgical options and outcomes.Nature reviews. Endocrinology, ,6 (11 ),637-45

Garrison, Aaron P; Helmrath, Michael A; Dekaney, Christopher M (2009. )Intestinal stem cells.Journal of pediatric gastroenterology and nutrition, ,49 (1 ),2-7

Inge, Thomas H; Miyano, Go; Bean, Judy; Helmrath, Michael; Courcoulas, Anita; Harmon, Carroll M; Chen, Mike K; Wilson, Kimberly; Daniels, Stephen R; Garcia, Victor F; Brandt, Mary L; Dolan, Lawrence M (2009. )Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents.Pediatrics, ,123 (1 ),214-22

Inge, Thomas; Helmrath, Michael; Vierra, Mark; Ikramuddin, Sayeed (2008. )Challenges of adolescent bariatric surgery: tips for managing the extremely obese teen.Journal of laparoendoscopic & advanced surgical techniques. Part A, ,18 (1 ),157-69

Inge, Thomas H; Zeller, Meg; Harmon, Carroll; Helmrath, Michael; Bean, Judy; Modi, Avani; Horlick, Mary; Kalra, Maninder; Xanthakos, Stavra; Miller, Rosemary; Akers, Rachel; Courcoulas, Anita (2007. )Teen-Longitudinal Assessment of Bariatric Surgery: methodological features of the first prospective multicenter study of adolescent bariatric surgery.Journal of pediatric surgery, ,42 (11 ),1969-71

Fuller, Megan K; Helmrath, Michael A (2007. )Thoracic empyema, application of video-assisted thoracic surgery and its current management.Current opinion in pediatrics, ,19 (3 ),328-32

De Silva, Nirupama K; Helmrath, Michael A; Klish, William J (2007. )Obesity in the adolescent female.Journal of pediatric and adolescent gynecology, ,20 (3 ),207-13

Helmrath, Michael A; Brandt, Mary L; Inge, Thomas H (2006. )Adolescent obesity and bariatric surgery.The Surgical clinics of North America, ,86 (2 ),441-54, x

Kenton, Alexander B; Hegemier, Suzanne; Smith, E O'Brian; O'Donovan, Donough J; Brandt, Mary L; Cass, Darrell L; Helmrath, Michael A; Washburn, Kimberly; Weihe, Elizabeth K; Fernandes, Caraciolo J (2005. )Platelet transfusions in infants with necrotizing enterocolitis do not lower mortality but may increase morbidity.Journal of perinatology : official journal of the California Perinatal Association, ,25 (3 ),173-7

Kenton, Alexander B; O'Donovan, Donough; Cass, Darrell L; Helmrath, Michael A; Smith, E O'brian; Fernandes, Caraciolo J; Washburn, Kimberly; Weihe, Elizabeth K; Brandt, Mary L (2005. )Severe thrombocytopenia predicts outcome in neonates with necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association, ,25 (1 ),14-20

Klish, William J; Brandt, Mary L; Helmrath, Michael A (2004. )Obesity surgery in pediatrics. Journal of pediatric gastroenterology and nutrition, ,39 (1 ),2-4

Inge, Thomas H; Krebs, Nancy F; Garcia, Victor F; Skelton, Joseph A; Guice, Karen S; Strauss, Richard S; Albanese, Craig T; Brandt, Mary L; Hammer, Lawrence D; Harmon, Carol M; Kane, Timothy D; Klish, William J; Oldham, Keith T; Rudolph, Colin D; Helmrath, Michael A; Donovan, Edward; Daniels, Stephen R (2004. )Bariatric surgery for severely overweight adolescents: concerns and recommendations. Pediatrics, ,114 (1 ),217-23

Bertaux-Skeirik, Nina; Wunderlich, Mark; Teal, Emma; Chakrabarti, Jayati; Biesiada, Jacek; Mahe, Maxime; Sundaram, Nambirajan; Gabre, Joel; Hawkins, Jennifer; Gao, Jian; Engevik, Amy C; Yang, Li; Wang, Jiang; Goldenring, James R; Qualls, Joseph E; Medvedovic, Mario; Helmrath, Michael A; Diwan, Tayyab; Mulloy, James C; Zavros, Yana (2017. )CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium.The Journal of pathology, ,

Zeller, Meg H; Pendery, Emma C; Reiter-Purtill, Jennifer; Hunsaker, Sanita L; Jenkins, Todd M; Helmrath, Michael A; Inge, Thomas H (2017. )From adolescence to young adulthood: trajectories of psychosocial health following Roux-en-Y gastric bypass.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, ,

Asai, Akihiro; Aihara, Eitaro; Watson, Carey; Mourya, Reena; Mizuochi, Tatsuki; Shivakumar, Pranavkumar; Phelan, Kieran; Mayhew, Christopher; Helmrath, Michael; Takebe, Takanori; Wells, James; Bezerra, Jorge A (2017. )Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells.Development (Cambridge, England), ,144 (6 ),1056-1064

Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut (2017. )Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells.Cell reports, ,18 (11 ),2608-2621

Inge, Thomas H; Jenkins, Todd M; Xanthakos, Stavra A; Dixon, John B; Daniels, Stephen R; Zeller, Meg H; Helmrath, Michael A (2017. )Long-term outcomes of bariatric surgery in adolescents with severe obesity (FABS-5+): a prospective follow-up analysis.The lancet. Diabetes & endocrinology, ,5 (3 ),165-173

Maxime, Mahe M; Brown, Nicole E; Poling, Holly M; Michael, Helmrath A (2017. )In Vivo Model of Small Intestine.Methods in molecular biology (Clifton, N.J.), ,1597 ,229-245

Workman, Michael J; Mahe, Maxime M; Trisno, Stephen; Poling, Holly M; Watson, Carey L; Sundaram, Nambirajan; Chang, Ching-Fang; Schiesser, Jacqueline; Aubert, Philippe; Stanley, Edouard G; Elefanty, Andrew G; Miyaoka, Yuichiro; Mandegar, Mohammad A; Conklin, Bruce R; Neunlist, Michel; Brugmann, Samantha A; Helmrath, Michael A; Wells, James M (2017. )Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.Nature medicine, ,23 (1 ),49-59

Hirschl, Ronald B; Minneci, Peter; Gadepalli, Samir; Saito, Jacqueline M; Askegard-Giesmann, Johanna; Deans, Katherine; Downard, Cynthia; Fallat, Mary; Finnell, Maria; Helmrath, Michael; Kabre, Rashmi; Lal, David; Leys, Charles; Mak, Grace; Ostlie, Daniel; Rescorla, Fred; Sato, Thomas; St Peter, Shawn; von Allmen, Daniel; Warner, Brad (2016. )Development of a multi-institutional clinical research consortium for pediatric surgery.Journal of pediatric surgery, ,

Lal, Dave R; Gadepalli, Samir K; Downard, Cynthia D; Ostlie, Daniel J; Minneci, Peter C; Swedler, Ruth M; Chelius, Thomas; Cassidy, Laura; Rapp, Cooper T; Deans, Katherine J; Fallat, Mary E; Finnell, S Maria E; Helmrath, Michael A; Hirschl, Ronald B; Kabre, Rashmi S; Leys, Charles M; Mak, Grace; Raque, Jessica; Rescorla, Frederick J; Saito, Jacqueline M; St Peter, Shawn D; von Allmen, Daniel; Warner, Brad W; Sato, Thomas T (2016. )Perioperative management and outcomes of esophageal atresia and tracheoesophageal fistula.Journal of pediatric surgery, ,

Cushing, Christopher C; Martinez-Leo, Bruno; Bischoff, Andrea; Hall, Jennifer; Helmrath, Michael; Dickie, Belinda H; Levitt, Marc A; Peña, Alberto; Zeller, Meg H; Frischer, Jason S (2016. )Health-Related Quality of Life and Parental Stress in Children With Fecal Incontinence: A Normative Comparison.Journal of pediatric gastroenterology and nutrition, ,63 (6 ),633-636

Cohran, Valeria; Managlia, Elizabeth; Bradford, Emily M; Goretsky, Tatiana; Li, Ting; Katzman, Rebecca B; Cheresh, Paul; Brown, Jeffrey B; Hawkins, Jennifer; Liu, Shirley X L; De Plaen, Isabelle G; Weitkamp, Jörn-Hendrik; Helmrath, Michael; Zhang, Zheng; Barrett, Terrence A (2016. )Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection.The American journal of pathology, ,186 (7 ),1837-46

Engevik, Amy C; Feng, Rui; Choi, Eunyoung; White, Shana; Bertaux-Skeirik, Nina; Li, Jing; Mahe, Maxime M; Aihara, Eitaro; Yang, Li; DiPasquale, Betsy; Oh, Sunghee; Engevik, Kristen A; Giraud, Andrew S; Montrose, Marshall H; Medvedovic, Mario; Helmrath, Michael A; Goldenring, James R; Zavros, Yana (2016. )The Development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach.Cellular and molecular gastroenterology and hepatology, ,2 (5 ),605-624

Mezoff, Ethan A; Hawkins, Jennifer A; Ollberding, Nicholas J; Karns, Rebekah; Morrow, Ardythe L; Helmrath, Michael A (2016. )The human milk oligosaccharide 2'-fucosyllactose augments the adaptive response to extensive intestinal.American journal of physiology. Gastrointestinal and liver physiology, ,310 (6 ),G427-38

Inge, Thomas H; Courcoulas, Anita P; Jenkins, Todd M; Michalsky, Marc P; Helmrath, Michael A; Brandt, Mary L; Harmon, Carroll M; Zeller, Meg H; Chen, Mike K; Xanthakos, Stavra A; Horlick, Mary; Buncher, C Ralph (2016. )Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents.The New England journal of medicine, ,374 (2 ),113-23

Moon, Changsuk; Zhang, Weiqiang; Sundaram, Nambirajan; Yarlagadda, Sunitha; Reddy, Vadde Sudhakar; Arora, Kavisha; Helmrath, Michael A; Naren, Anjaparavanda P (2015. )Drug-induced secretory diarrhea: A role for CFTR.Pharmacological research, ,102 ,107-12

Aihara, Eitaro; Mahe, Maxime M; Schumacher, Michael A; Matthis, Andrea L; Feng, Rui; Ren, Wenwen; Noah, Taeko K; Matsu-ura, Toru; Moore, Sean R; Hong, Christian I; Zavros, Yana; Herness, Scott; Shroyer, Noah F; Iwatsuki, Ken; Jiang, Peihua; Helmrath, Michael A; Montrose, Marshall H (2015. )Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid.Scientific reports, ,5 ,17185

Contact Information

Academic - Cincinnati Children's Hospital Medical Center
Department of Pediatric Surgery
Cincinnati  Ohio, 45229
Phone: 513-636-8318
michael.helmrath@cchmc.org