Robert F Highsmith, PhD

Doctoral Degree: University of Cincinnati 1972 (Physiology and Biophysics)

Postdoctoral Fellowship: Harvard Medical Schoo Boston, MA, 1974

Intercellular Signalling within the Blood Vessel Wall of Coronary Arteries.

Grant: #53000236-HHMI-04-A0-S0-E0 Investigators:Highsmith, Robert 01-01-2000 -12-31-2005 Howard Hughes Medical Institute Infrastructure for Expression Technology Role:PI $1,933,333.00 Closed Level:Private Non-Profit

Grant: #108782 \ 1 F30HL104892-01; 5F30HL104892-02 Investigators:Highsmith, Robert; Lu, Thomas 07-01-2011 -03-15-2012 National Heart, Lung and Blood Institute miR-21 in the Pathogenesis of Asthma Role:Collaborator $29,892.00 Active Level:Federal

Grant: #F30HL104892 Investigators:Highsmith, Robert; Lu, Thomas 08-16-2012 -08-15-2013 National Heart, Lung and Blood Institute MiR-21 in the Pathogenesis of Asthma Role:Collaborator $45,364.00 Active Level:Federal

Peer Reviewed Publications

Guard, J Roger; Brueggemann, Ralph F; Highsmith, Robert F; Marine, Stephen A; Riep, Josette R; Schick, Leslie C  (2005). Building research administration applications for the academic health center: a case study. Academic medicine : journal of the Association of American Medical Colleges, 80 (11) , 1032-8

Hubel, C A; Highsmith, R F  (1995). Endothelin-induced changes in intracellular pH and Ca2+ in coronary smooth muscle: role of Na(+)-H+ exchange. The Biochemical journal, 310 ( Pt 3), 1013-20

Pollock, D M; Keith, T L; Highsmith, R F  (1995). Endothelin receptors and calcium signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 9 (12) , 1196-204

Heffernan, M; Chance, A; Hess, E V; Highsmith, R F; FitzGerald, O  (1994). Alterations in human endothelial cell morphology, proliferation and function by a macrophage-derived factor. Irish journal of medical science, 163 (8) , 359-65

Sawaya, R; Highsmith, R F  (1992). Postoperative venous thromboembolism and brain tumors: Part III. Biochemical profile. Journal of neuro-oncology, 14 (2) , 113-8

Highsmith, R F; Blackburn, K; Schmidt, D J  (1992). Endothelin and calcium dynamics in vascular smooth muscle. Annual review of physiology, 54, 257-77More Information

Blackburn, K; Highsmith, R F  (1990). Nickel inhibits endothelin-induced contractions of vascular smooth muscle. The American journal of physiology, 258 (6 Pt 1) , C1025-30

Rapoport, R M; Stauderman, K A; Highsmith, R F  (1990). Effects of EDCF and endothelin on phosphatidylinositol hydrolysis and contraction in rat aorta. The American journal of physiology, 258 (1 Pt 1) , C122-31

Highsmith, R F; Pang, D C; Rapoport, R M  (1989). Endothelial cell-derived vasoconstrictors: mechanisms of action in vascular smooth muscle. Journal of cardiovascular pharmacology, 13 Suppl 5, S36-44; discussion S

Whitmer, K R; Williams-Lawson, J S; Highsmith, R F; Schwartz, A  (1988). Effect of calcium channel modulators on isolated endothelial cells. Biochemical and biophysical research communications, 154 (2) , 591-605

Neely, A N; Nathan, P; Highsmith, R F  (1988). Plasma proteolytic activity following burns. The Journal of trauma, 28 (3) , 362-7

FitzGerald, O M; Hess, E V; Chance, A; Highsmith, R F  (1987). Quantitative studies of human monokine-induced endothelial cell elongation. Journal of leukocyte biology, 41 (5) , 421-8

Ramey, J W; Krummen, L A; Wilfinger, W W; Highsmith, R F; Baldwin, D M  (1987). Effects of a low calcium environment on luteinizing hormone biosynthesis in cultured rat anterior pituitary cells. Endocrinology, 120 (4) , 1514-20More Information

Ramey, J W; Highsmith, R F; Wilfinger, W W; Baldwin, D M  (1987). The effects of gonadotropin-releasing hormone and estradiol on luteinizing hormone biosynthesis in cultured rat anterior pituitary cells. Endocrinology, 120 (4) , 1503-13More Information

Baldwin, D M; Highsmith, R F; Ramey, J W; Krummen, L A  (1986). An in vitro study of LH release, synthesis and heterogeneity in pituitaries from proestrous and short-term ovariectomized rats. Biology of reproduction, 34 (2) , 304-15

Hickey, K A; Rubanyi, G; Paul, R J; Highsmith, R F  (1985). Characterization of a coronary vasoconstrictor produced by cultured endothelial cells. The American journal of physiology, 248 (5 Pt 1) , C550-6

Marcum, J A; Highsmith, R F; Kline, D L  (1982). Streptokinase-dependent delayed activation of horse plasminogen. Biochimica et biophysica acta, 709 (1) , 19-27

Highsmith, R F  (1981). Isolation and properties of a plasminogen activator derived from canine vascular tissue. The Journal of biological chemistry, 256 (13) , 6788-95

Highsmith, R F; Burnett, C J; Weirich, C J  (1979). The interaction of C1-esterase inhibitor and plasmin in human euglobulin. The Journal of laboratory and clinical medicine, 93 (3) , 459-71

Highsmith, R F; Weirich, C J; Burnett, C J  (1977). Protease inhibitors and human plasmin: interaction in a whole plasma system. Biochemical and biophysical research communications, 79 (3) , 648-56

Highsmith, R F; Rosenberg, R D  (1977). A rapid and sensitive proteolytic assay for human plasminogen and plasmin using radioiodinated alpha-casein. Thrombosis research, 11 (2) , 131-40

Highsmith, R F; Rosenberg, R D  (1974). The inhibition of human plasmin by human antithrombin-heparin cofactor. The Journal of biological chemistry, 249 (14) , 4335-8

Highsmith, R F; Kline, D L  (1973). Plasminogen restoration by the kidney mediated by a plasma factor. The American journal of physiology, 225 (5) , 1032-7

Kline, D L; Highsmith, R F  (1973). The regulation of blood levels of fibrinolytic enzymes. Series haematologica, 6 (4) , 513-27

Highsmith, R F; Kline, D L  (1971). Kidney: primary source of plasminogen after acute depletion in the cat. Science (New York, N.Y.), 174 (4005) , 141-2

Physiologist,Cell Biologist,Protein Chemist,Pharmacologist,Protein chemistry,Cellular Physiology,Cellular regulation and integration,Control of biosynthesis,Receptors,Cells and platelets,Acute myocardial infarction,Coronary artery disease,Hemodynamics and vasomotor control,Regional vascular pattern,Thrombosis and embolism,Dose-response studies,Graduate education,Medical education

Academic - Medical Sciences Building
Room 2005G
Cincinnati  Ohio, 45267-0548
Phone: 513-558-5459
Fax: 513-558-2850
robert.highsmith@uc.edu