Christy Holland

Christy K. Holland

Professor of Internal Medicine, Division of Cardiovascular Diseases; Professor of Biomedical Engineering; Director, Image-Guided Ultrasound Therapeutics Laboratories; Scientific Director, Heart, Lung, and Vascular Institute

Cardiovascular Rsrch Cntr

3935

COM IM Cardiology Division - 0586

Cardiovascular Center
231 Albert Sabin Way
Cincinnati, Ohio 45267-0586

Professional Summary

Christy K. Holland, PhD, attended Wellesley College where she completed a double major (BA) in Physics and Music in 1983.  She completed M.S.(1985), M.Phil. (1986), and Ph.D. (1988) degrees at Yale University in Engineering and Applied Science.  She is currently a Professor in both the College of Medicine and the College of Engineering and Applied Sciences at the University of Cincinnati (UC) with joint appointments in the Department of Internal Medicine, Division of Cardiovascular Health and Disease, and the Department of Biomedical Engineering (BME).  Prof. Holland serves as Scientific Director of the Heart, Lung, and Vascular Institute, a key component of efforts to align the UC College of Medicine and UC Health efforts around research, education, and clinical programs.  She is a fellow of the Acoustical Society of America, the American Institute of Ultrasound in Medicine, the American Institute for Medical and Biological Engineering, and the Executive Leadership in Academic Medicine®. Prof. Holland continues to serve as Editor-in-Chief of Ultrasound in Medicine and Biology, the official Journal of the World Federation for Ultrasound in Medicine and Biology, a post she assumed in 2006.  She served as President of the Acoustical Society of America from 2015 to 2017.  She is actively involved in teaching biomedical engineering and biomedical ultrasound in the BME undergraduate and graduate curricula and received teaching awards in the UC Colleges of Engineering and Medicine in 2008 and 2009.  She served as the Director of Graduate Studies for BME in 2007-2009.  She mentors and advises students within and outside of BME educational programs.  Prof. Holland’s research interests include ultrasound-enhanced thrombolysis for stroke therapy, ultrasound-mediated drug delivery, bioeffects of diagnostic and therapeutic ultrasound, and acoustic cavitation.  She directs the Image-guided Ultrasound Therapeutics Laboratories in the UC Cardiovascular Center, which focus on applications of biomedical ultrasound including sonothrombolysis, ultrasound-mediated drug and bioactive gas delivery, development of echogenic liposomes, early detection of cardiovascular diseases, and ultrasound-image guided tumor ablation.  Prof. Holland has gained wide recognition at UC, nationally and internationally for her excellence and contributions in ultrasound research, published in more than 115 scientific publications and 8 patents. 

Education

Ph.D., Yale University 1989 (Engineering and Applied Science)

M.S., Yale University 1987 (Engineering and Applied Science)

M.Phil., Yale University 1985 (Engineering and Applied Science)

B.A., Wellesley College 1983 (Physics and Music (Cum Laude))

Research Support

Grant: #2 R01 NS047603 Investigators:Holland 12-01-2008 -11-30-2013 NIH//NINDS Ultrasound-Assisted Thrombolysis for Stroke Therapy Role:PI $3,532,870

Grant: #2 R01 HL074002 Investigators:Holland 04-01-2010 -03-31-2014 NIH/NHLBI Echogenic Targeted Liposomes for Transfection/Drug Delivery Role:PI $1,095,100

Grant: #2 R01 HL059586 Investigators:Holland 12-01-2008 -11-30-2012 NIH/NHLBI Targeted Liposomes for Acoustic Cardiovascular Imaging Role:PI $1,455,433

Grant: #1 R21EB008483 Investigators:Holland 02-01-2009 -01-31-2011 NIH/NIBIB Passive cavitation imaging for ultrasound guidance and control of thermal ablation $150,000

Grant: #P50 NS044283 Investigators:Shaw, Holland 02-15-2009 -04-30-2013 NIH/NINDS SPOTRIAS-II: Recanalization therapies and markers of stroke outcome Project 3: TRUST (Transcranial Ultrasound Treatment for Stroke)

Grant: #0600 370 FZ42 729 / R01 HL059586 Investigators:Holland, Christy 07-01-2003 -08-31-2006 National Heart, Lung and Blood Institute Acoustic Targeted Liposomes for Transfection and Drug Delivery Role:PI $325,928.00 Closed Level:Federal

Grant: #0600 370 FZ43 918 / R01 HL074002 Investigators:Holland, Christy 04-01-2004 -07-31-2006 National Heart, Lung and Blood Institute Acoustic Targeted Liposomes for Transfection and Drug Delivery Role:PI $411,741.00 Closed Level:Federal

Grant: #R29-EB-000284 Investigators:Holland, Christy 04-01-2002 -03-31-2003 National Institute of Biomedical Imaging and Bioengineering Mechanicl Bioeffects Due to Diagnostic Ultrasound Role:PI $98,897.00 Closed Level:Federal

Grant: #R01-NS-047603 Investigators:Holland, Christy 07-01-2004 -02-14-2009 National Institute of Neurological Disorders and Stroke Ultrasound Assisted Thrombolysis for Stroke Therapy Role:PI $2,297,981.00 Closed Level:Federal

Grant: #NEURO-01-01-A0-S0-E0 Investigators:Holland, Christy 11-01-1999 -12-31-2001 University of Cincinnati Neuroscience Institute Transcranial Ultrasound Thrombolysis Role:PI $25,000.00 Closed Level:Industry

Grant: #SenMed-02-A0-S0-E0 Investigators:Holland, Christy 05-01-2001 -05-31-2003 Sentron Medical, Inc. Development of Transcranial Ultrasound Thrombolysis Role:PI $441,562.00 Closed Level:Industry

Grant: #5-R29-HL-58761-04-A0-S0-E0 Investigators:Holland, Christy 04-01-1998 -03-31-2002 National Heart, Lung and Blood Institute Mechanical Bioeffects in Lung Due to Diagnostic Ultrasound Role:PI $418,421.00 Closed Level:Federal

Grant: #1-R13-HL-61450-01-A0-S0-E0 Investigators:Holland, Christy 01-01-1999 -12-31-1999 National Heart, Lung and Blood Institute AIUM Mechanical Bioeffects Conference Role:PI $19,800.00 Closed Level:Federal

Grant: #0005534A / HL074002-04 Investigators:Ammi, Azzdine; Holland, Christy 04-01-2007 -03-31-2009 National Heart, Lung and Blood Institute Echogenic Targeted Liposomes: Transfection/Drug Delivery Role:PI $252,053.00 Closed Level:Federal

Grant: #SRS 004874 Investigators:Abruzzo, Todd; Caudell Stamper, Danielle; Holland, Christy; Pyne-Geithman, Gail Jean 01-01-2007 -12-31-2011 University of Cincinnati Neuroscience Institute Ultrasound-Enhanced Thrombolysis in an Ex Vivo Rat Carotid Artery Role:PI $8,655.59 Active Level:Industry

Grant: #HL059586 / 0005533A Investigators:Holland, Christy 09-15-2006 -05-31-2009 National Heart, Lung and Blood Institute Targeted Liposomes for Acoustic Cardiovascular Imaging Role:PI $246,763.00 Closed Level:Federal

Grant: #P50 NS044283 Investigators:Broderick, Joseph; Clark, Joseph; Flaherty, Matthew; Holland, Christy; Jauch, Edward; Lindsell, Christopher; Lu, Aigang; Pancioli, Arthur; Pyne-Geithman, Gail Jean; Shaw, George 08-01-2008 -04-30-2013 National Institute of Neurological Disorders and Stroke Recanalization Therapies and Markers of Stroke Outcome Role:Collaborator $7,150,853.00 Active Level:Federal

Grant: #R21 EB008483 Investigators:Holland, Christy; Mast, T. Douglas; Rao, Marepalli; Rudich, Steven 02-01-2009 -01-31-2012 National Institute of Biomedical Imaging and Bioengineering Passive Cavitation Imaging for Guidance and Control of Ultrasound Ablation Role:Collaborator $387,043.00 Active Level:Federal

Grant: #R01 NS047603 Investigators:Holland, Christy; Mast, T. Douglas; Shaw, George; Wagner, Kenneth 02-15-2009 -01-31-2013 National Institute of Neurological Disorders and Stroke Ultrasound-Assisted Thrombolysis for Stroke Therapy Role:PI $1,769,841.00 Active Level:Federal

Grant: #0006871A / R02 HL059586-08A1 Investigators:Holland, Christy 03-14-2009 -02-28-2012 National Heart, Lung and Blood Institute Targeted Liposomes for Acoustic Cardiovascular Imaging Role:PI $397,279.00 Active Level:Federal

Grant: #0007526A Investigators:Holland, Christy; Pyne-Geithman, Gail Jean 04-15-2010 -03-31-2012 National Heart, Lung and Blood Institute Echogenic Targeted Liposomes: Transfection/Drug Delivery Role:PI $377,803.00 Active Level:Federal

Grant: #F32 HL104916 Investigators:Haworth, Kevin; Holland, Christy; Mast, T. Douglas 09-01-2010 -08-31-2012 National Heart, Lung and Blood Institute Passive Cavitation Image-Guided Ultrasound-Mediated Drug Delivery for Atheroma Therapy Role:Collaborator $102,974.00 Active Level:Federal

Grant: #2R01NS047603-09 Investigators:Holland, Christy 08-15-2014 -07-31-2019 National Institute of Neurological Disorders and Stroke Ultrasound-Assisted Thrombolysis for Stroke Therapy Role:PI $581,417.00 Awarded Level:Federal

Grant: #URC Interdisciplinary Award AY2015-16 Investigators:Haworth, Kevin; Holland, Christy; Papautsky, Ian 05-01-2016 -04-30-2017 UC's University Research Council MICROFLUIDIC MANUFACTURING OF PERFLUOROCARBON DROPLETS FOR ACOUSTIC DROPLET VAPORIZATION Role:Collaborator $25,000.00 Active Level:Internal UC

Grant: #3 R01 NS047603 Investigators:PI: Holland 07-01-2014 -06-30-2019 NIH/NINDS Ultrasound-Assisted Thrombolysis for Stroke Therapy Role:PI $3,457,621 Total Active Type:Grant

Grant: #FP066598-B / R01 HL133334 Investigators:Haworth, Kevin; Holland, Christy; Lynch, Donald 12-15-2017 -11-30-2022 National Heart, Lung and Blood Institute Chronic thrombus ablation with histotripsy and thrombolytics Role:PI $220,899.00 Active Level:Federal

Grant: #1 R01 HL135092 Investigators:Holland, Haworth, McPherson 09-01-2017 -08-31-2022 NIH/NHLBI Echogenic targeted liposomes: Transfection/Drug Delivery Role:PI of Subaward $3,741,010 Total Active Type:Grant

Grant: #R01 NS047603 Supplement Investigators:Mercado-Shekhar, Holland 08-01-2016 -09-30-2018 NIH/NINDS Research Supplement to Promote Diversity Role:PI and Mentor $173,534 Total Active Type:Grant

Grant: #R01 HL148451 Investigators:Haworth, Kevin; Holland, Christy; Lorenz, John 07-01-2019 -04-30-2024 National Heart, Lung and Blood Institute Ultrasound-mediated Controlled Hypoxemic Reperfusion for Inhibition of Reperfusion Injury Role:Collaborator $773,375.00 Awarded Level:Federal

Grant: #1 R01 HL133334 Investigators:Holland, Haworth, Bader 12-01-2017 -11-30-2022 NIH/NHLBI Localized thrombus ablation with histotripsy and echogenic liposomes Role:PI of Subaward $3,771,235 Total Active Type:Grant

Grant: #K25 HL133452 Investigators:Haworth, Holland, Redington 07-01-2016 -06-30-2020 NIH/NHLBI Ultrasound-mediated oxygen scavenging for inhibition of reperfusion injury Role:Mentor $639,441 Total Active Type:Grant

Publications

Peer Reviewed Publications

Gonzalez T.; Herr A.; Holland C.; Kooiman K.; Lattwein K.; Shekhar H.; Van Wamel W. (12-01-2018. )An in vitro proof-of-principle study of sonobactericide.Scientific Reports, ,8 (1 ),

Holland C.; Raymond J.; Shekhar H.; Smith N. (02-01-2018. )Effect of Temperature on the Size Distribution, Shell Properties, and Stability of Definity.Ultrasound in Medicine and Biology, ,44 (2 ),434-446

Bader K.; Haworth K.; Holland C.; Maxwell A. (01-01-2018. )Post Hoc Analysis of Passive Cavitation Imaging for Classification of Histotripsy-Induced Liquefacti.IEEE Transactions on Medical Imaging, ,37 (1 ),106-115

Lattwein, Kirby R; Shekhar, Himanshu; van Wamel, Willem J B; Gonzalez, Tammy; Herr, Andrew B; Holland, Christy K; Kooiman, Klazina (2018. )An in vitro proof-of-principle study of sonobactericide.Scientific reports, ,8 (1 ),3411

Shekhar, Himanshu; Smith, Nathaniel J; Raymond, Jason L; Holland, Christy K (2018. )Effect of Temperature on the Size Distribution, Shell Properties, and Stability of Definity®.Ultrasound in medicine & biology, ,44 (2 ),434-446

Goldstein B.; Haworth K.; Holland C.; Mercado-Shekhar K.; Redington A. (10-31-2017. )Dissolved oxygen scavenging by acoustic droplet vaporization using intravascular ultrasound.IEEE International Ultrasonics Symposium, IUS, ,

Arunkumar P.; Goldstein B.; Haworth K.; Holland C.; Mercado-Shekhar K.; Privitera E.; Redington A.; Srivastava R.; Su H. (10-31-2017. )Dissolved oxygen scavenging by acoustic droplet vaporization using intravascular ultrasound.IEEE International Ultrasonics Symposium, IUS, ,

Bader K.; Haworth K.; Holland C.; Mast T.; Rich K. (01-01-2017. )Quantitative frequency-domain passive cavitation imaging.IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, ,64 (1 ),177-191

Beigel, John H; Tebas, Pablo; Elie-Turenne, Marie-Carmelle; Bajwa, Ednan; Bell, Todd E; Cairns, Charles B; Shoham, Shmuel; Deville, Jaime G; Feucht, Eric; Feinberg, Judith; Luke, Thomas; Raviprakash, Kanakatte; Danko, Janine; O'Neil, Dorothy; Metcalf, Julia A; King, Karen; Burgess, Timothy H; Aga, Evgenia; Lane, H Clifford; Hughes, Michael D; Davey, Richard T (2017. )Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study.The Lancet. Respiratory medicine, ,5 (6 ),500-511

Huang, Shenwen; Shekhar, Himanshu; Holland, Christy K (2017. )Comparative lytic efficacy of rt-PA and ultrasound in porcine versus human clots.PloS one, ,12 (5 ),e0177786

Shekhar, Himanshu; Bader, Kenneth B; Huang, Shenwen; Peng, Tao; Huang, Shaoling; McPherson, David D; Holland, Christy K (2017. )In vitro thrombolytic efficacy of echogenic liposomes loaded with tissue plasminogen activator and octafluoropropane gas.Physics in medicine and biology, ,62 (2 ),517-538

Haworth K.; Holland C.; Huang S.; Kim H.; Klegerman M.; McPherson D.; Moody M.; Peng T.; Radhakrishnan K.; Raymond J.; Shekhar H. (05-01-2016. )Erratum to: "Trans-stent B-mode Ultrasound and Passive Cavitation Imaging" in Ultrasound Med Biol 20.Ultrasound in Medicine and Biology, ,42 (5 ),1244

Holland C. (04-01-2016. )ACOUSTICAL NEWS-USA.Journal of the Acoustical Society of America, ,139 (4 ),

Raymond, Jason L; Luan, Ying; Peng, Tao; Huang, Shao-Ling; McPherson, David D; Versluis, Michel; de Jong, Nico; Holland, Christy K (2016. )Loss of gas from echogenic liposomes exposed to pulsed ultrasound.Physics in medicine and biology, ,61 (23 ),8321-8339

Sutton, J T; Haworth, K J; Shanmukhappa, S K; Moody, M R; Klegerman, M E; Griffin, J K; Patton, D M; McPherson, D D; Holland, C K (2016. )Delivery of bevacizumab to atheromatous porcine carotid tissue using echogenic liposomes.Drug delivery, ,23 (9 ),3594-3605

Bader, Kenneth B; Haworth, Kevin J; Shekhar, Himanshu; Maxwell, Adam D; Peng, Tao; McPherson, David D; Holland, Christy K (2016. )Efficacy of histotripsy combined with rt-PA in vitro.Physics in medicine and biology, ,61 (14 ),5253-74

Radhakrishnan, Kirthi; Holland, Christy K; Haworth, Kevin J (2016. )Scavenging dissolved oxygen via acoustic droplet vaporization.Ultrasonics sonochemistry, ,31 ,394-403

Bader, Kenneth B; Crowe, Michael J; Raymond, Jason L; Holland, Christy K (2016. )Effect of Frequency-Dependent Attenuation on Predicted Histotripsy Waveforms in Tissue-Mimicking Phantoms.Ultrasound in medicine & biology, ,42 (7 ),1701-5

Kandadai, Madhuvanthi A; Mukherjee, Prithviraj; Shekhar, Himanshu; Shaw, George J; Papautsky, Ian; Holland, Christy K (2016. )Microfluidic manufacture of rt-PA -loaded echogenic liposomes.Biomedical microdevices, ,18 (3 ),48

Haworth, Kevin J; Raymond, Jason L; Radhakrishnan, Kirthi; Moody, Melanie R; Huang, Shao-Ling; Peng, Tao; Shekhar, Himanshu; Klegerman, Melvin E; Kim, Hyunggun; McPherson, David D; Holland, Christy K (2016. )Erratum to: "Trans-stent B-mode Ultrasound and Passive Cavitation Imaging" in Ultrasound Med Biol 2016;42(2):518-527.Ultrasound in medicine & biology, ,42 (5 ),1244

Bader, Kenneth B; Holland, Christy K (2016. )Predicting the growth of nanoscale nuclei by histotripsy pulses.Physics in medicine and biology, ,61 (7 ),2947-66

Haworth, Kevin J; Raymond, Jason L; Radhakrishnan, Kirthi; Moody, Melanie R; Huang, Shao-Ling; Peng, Tao; Shekhar, Himanshu; Klegerman, Melvin E; Kim, Hyunggun; McPherson, David D; Holland, Christy K (2016. )Trans-Stent B-Mode Ultrasound and Passive Cavitation Imaging.Ultrasound in medicine & biology, ,42 (2 ),518-27

Bader, Kenneth B; Bouchoux, Guillaume; Holland, Christy K (2016. )Sonothrombolysis.Advances in experimental medicine and biology, ,880 ,339-62

Klegerman, Melvin E; Naji, Ali K; Haworth, Kevin J; Zou, Yuejiao; Golunski, Eva; Peng, Tao; Britton, George L; Huang, Shao-Ling; Holland, Christy K; McPherson, David D (2016. )Ultrasound-enhanced bevacizumab release from echogenic liposomes for inhibition of atheroma progression.Journal of liposome research, ,26 (1 ),47-56

Bader K.; Holland C. (10-28-2015. )Development of a hybrid finite difference solution of the Westervelt equation using the fast nearfie.AIP Conference Proceedings, ,1685 ,

Holland C.; Kandadai M.; Mukherjee P.; Papautsky I.; Shaw G. (01-01-2015. )Generation of drug loaded echogenic liposomes using microfluidic hydrodynamic focusing .MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, ,466-468

Bader, Kenneth B; Bouchoux, Guillaume; Peng, Tao; Klegerman, Melvin E; McPherson, David D; Holland, Christy K (2015. )Thrombolytic efficacy and enzymatic activity of rt-PA-loaded echogenic liposomes.Journal of thrombosis and thrombolysis, ,

Haworth, Kevin J; Salgaonkar, Vasant A; Corregan, Nicholas M; Holland, Christy K; Mast, T Douglas (2015. )Using Passive Cavitation Images to Classify High-Intensity Focused Ultrasound Lesions.Ultrasound in medicine & biology, ,41 (9 ),2420-34

Holland, C (2015. )WE-D-210-03: Microbubble Pumps: Â Ultrasound Theragnostic Agents.Medical physics, ,42 (6 ),3672

Raymond, Jason L; Luan, Ying; van Rooij, Tom; Kooiman, Klazina; Huang, Shao-Ling; McPherson, David D; Versluis, Michel; de Jong, Nico; Holland, Christy K (2015. )Impulse response method for characterization of echogenic liposomes.The Journal of the Acoustical Society of America, ,137 (4 ),1693-703

Kandadai, Madhuvanthi A; Meunier, Jason M; Hart, Kimberley; Holland, Christy K; Shaw, George J (2015. )Plasmin-loaded echogenic liposomes for ultrasound-mediated thrombolysis.Translational stroke research, ,6 (1 ),78-87

Radhakrishnan, Kirthi; Haworth, Kevin J; Peng, Tao; McPherson, David D; Holland, Christy K (2015. )Loss of echogenicity and onset of cavitation from echogenic liposomes: pulse repetition frequency independence.Ultrasound in medicine & biology, ,41 (1 ),208-21

Bader, Kenneth B; Gruber, Matthew J; Holland, Christy K (2015. )Shaken and stirred: mechanisms of ultrasound-enhanced thrombolysis.Ultrasound in medicine & biology, ,41 (1 ),187-96

Bouchoux, Guillaume; Shivashankar, Ravishankar; Abruzzo, Todd A; Holland, Christy K (2014. )In silico study of low-frequency transcranial ultrasound fields in acute ischemic stroke patients.Ultrasound in medicine & biology, ,40 (6 ),1154-66

Haworth, Kevin J; Weidner, Christopher R; Abruzzo, Todd A; Shearn, Jason T; Holland, Christy K (2014. )Mechanical properties and fibrin characteristics of endovascular coil-clot complexes: relevance to endovascular cerebral aneurysm repair paradigms.Journal of neurointerventional surgery, ,

Gruber, Matthew J; Bader, Kenneth B; Holland, Christy K (2014. )Cavitation thresholds of contrast agents in an in vitro human clot model exposed to 120-kHz ultrasound.The Journal of the Acoustical Society of America, ,135 (2 ),646-53

Raymond, Jason L; Haworth, Kevin J; Bader, Kenneth B; Radhakrishnan, Kirthi; Griffin, Joseph K; Huang, Shao-Ling; McPherson, David D; Holland, Christy K (2014. )Broadband attenuation measurements of phospholipid-shelled ultrasound contrast agents.Ultrasound in medicine & biology, ,40 (2 ),410-21

Sutton, J T; Raymond, J L; Verleye, M C; Pyne-Geithman, G J; Holland, C K (2014. )Pulsed ultrasound enhances the delivery of nitric oxide from bubble liposomes to ex vivo porcine carotid tissue.International journal of nanomedicine, ,9 ,4671-83

Kim, Hyunggun; Britton, George L; Peng, Tao; Holland, Christy K; McPherson, David D; Huang, Shao-Ling (2014. )Nitric oxide-loaded echogenic liposomes for treatment of vasospasm following subarachnoid hemorrhage.International journal of nanomedicine, ,9 ,155-65

Corregan N.; Haworth K.; Holland C.; Mast T.; Salgaonkar V. (06-19-2013. )Spatial specificity and sensitivity of passive cavitation imaging for monitoring high-intensity focu.Proceedings of Meetings on Acoustics, ,19 ,

Ferrara K.; Griffin R.; Guha C.; Holland C.; Lafon C. (01-01-2013. )TU?E?144?01: Advanced Novel Technologies & Therapeutic Strategies.Medical Physics, ,40 (6 ),451

Radhakrishnan, Kirthi; Bader, Kenneth B; Haworth, Kevin J; Kopechek, Jonathan A; Raymond, Jason L; Huang, Shao-Ling; McPherson, David D; Holland, Christy K (2013. )Relationship between cavitation and loss of echogenicity from ultrasound contrast agents.Physics in medicine and biology, ,58 (18 ),6541-63

Kopechek, Jonathan A; Haworth, Kevin J; Radhakrishnan, Kirthi; Huang, Shao-Ling; Klegerman, Melvin E; McPherson, David D; Holland, Christy K (2013. )The impact of bubbles on measurement of drug release from echogenic liposomes.Ultrasonics sonochemistry, ,20 (4 ),1121-30

Sutton, Jonathan T; Haworth, Kevin J; Pyne-Geithman, Gail; Holland, Christy K (2013. )Ultrasound-mediated drug delivery for cardiovascular disease.Expert opinion on drug delivery, ,10 (5 ),573-92

Sutton, Jonathan T; Ivancevich, Nikolas M; Perrin, Stephen R; Vela, Deborah C; Holland, Christy K (2013. )Clot retraction affects the extent of ultrasound-enhanced thrombolysis in an ex vivo porcine thrombosis model.Ultrasound in medicine & biology, ,39 (5 ),813-24

Bader, Kenneth B; Holland, Christy K (2013. )Gauging the likelihood of stable cavitation from ultrasound contrast agents.Physics in medicine and biology, ,58 (1 ),127-44

Sutton, J. T.; Ivancevich, N. M.; Perrin, S. R., Jr.; Vela, D. C.; Holland, C. K. (2013. )Clot retraction affects the extent of ultrasound-enhanced thrombolysis in an ex vivo porcine thrombosis model .Ultrasound Med Biol, ,39 (5 ),813-24

Sutton, J. T.; Haworth, K. J.; Pyne-Geithman, G.; Holland, C. K. (2013. )Ultrasound-mediated drug delivery for cardiovascular disease .Expert Opin Drug Deliv, ,10 (5 ),573-92

Kopechek, J. A.; Haworth, K. J.; Radhakrishnan, K.; Huang, S. L.; Klegerman, M. E.; McPherson, D. D.; Holland, C. K. (2013. )The impact of bubbles on measurement of drug release from echogenic liposomes .Ultrason Sonochem, ,20 (4 ),1121-30

Haworth, K. J.; Salgaonkar, V. A.; Corregan, N. M.; Holland, C. K.; Mast, T. D. (2013. )Spatial specificity and sensitivity of passive cavitation imaging for monitoring high-intensity focused ultrasound thermal ablation in ex vivo bovine liver .J Acoust Soc Am, ,133 (5 ),3263

Bader, K. B.; Holland, C. K. (2013. )Gauging the likelihood of stable cavitation from ultrasound contrast agents .Phys Med Biol, ,58 (1 ),127-44

Holland C.; Huang S.; Kim H.; Klegerman M.; Laing S.; McPherson D.; Moody M.; Smulevitz B. (10-01-2012. )Thrombolytic efficacy of tissue plasminogen activator-loaded echogenic liposomes in a rabbit thrombu.Thrombosis Research, ,130 (4 ),629-635

Bouchoux, Guillaume; Bader, Kenneth B; Korfhagen, Joseph J; Raymond, Jason L; Shivashankar, Ravishankar; Abruzzo, Todd A; Holland, Christy K (2012. )Experimental validation of a finite-difference model for the prediction of transcranial ultrasound fields based on CT images.Physics in medicine and biology, ,57 (23 ),8005-22

Radhakrishnan, Kirthi; Haworth, Kevin J; Huang, Shao-Ling; Klegerman, Melvin E; McPherson, David D; Holland, Christy K (2012. )Stability of echogenic liposomes as a blood pool ultrasound contrast agent in a physiologic flow phantom.Ultrasound in medicine & biology, ,38 (11 ),1970-81

Huppert, Jill S; Reed, Jennifer L; Munafo, Jennifer Knopf; Ekstrand, Rachel; Gillespie, Gordon; Holland, Carolyn; Britto, Maria T (2012. )Improving notification of sexually transmitted infections: a quality improvement project and planned experiment.Pediatrics, ,130 (2 ),e415-22

Haworth, Kevin J; Mast, T Douglas; Radhakrishnan, Kirthi; Burgess, Mark T; Kopechek, Jonathan A; Huang, Shao-Ling; McPherson, David D; Holland, Christy K (2012. )Passive imaging with pulsed ultrasound insonations.The Journal of the Acoustical Society of America, ,132 (1 ),544-53

Radhakrishnan, K.; Haworth, K. J.; Huang, S. L.; Klegerman, M. E.; McPherson, D. D.; Holland, C. K. (2012. )Stability of echogenic liposomes as a blood pool ultrasound contrast agent in a physiologic flow phantom .Ultrasound Med Biol, ,38 (11 ),1970-81

Laing, S. T.; Moody, M. R.; Kim, H.; Smulevitz, B.; Huang, S. L.; Holland, C. K.; McPherson, D. D.; Klegerman, M. E. (2012. )Thrombolytic efficacy of tissue plasminogen activator-loaded echogenic liposomes in a rabbit thrombus model .Thromb Res, ,130 (4 ),629-35

Haworth, K. J.; Mast, T. D.; Radhakrishnan, K.; Burgess, M. T.; Kopechek, J. A.; Huang, S. L.; McPherson, D. D.; Holland, C. K. (2012. )Passive imaging with pulsed ultrasound insonations .J Acoust Soc Am, ,132 (1 ),544-53

Bouchoux, G.; Bader, K. B.; Korfhagen, J. J.; Raymond, J. L.; Shivashankar, R.; Abruzzo, T. A.; Holland, C. K. (2012. )Experimental validation of a finite-difference model for the prediction of transcranial ultrasound fields based on CT images .Phys Med Biol, ,57 (23 ),8005-22

Holland C.; Huang S.; Kee P.; Kim H.; Laing S.; McPherson D.; Moody M.; Smulevitz B. (06-01-2011. )Ultrasound-enhanced thrombolytic effect of tissue plasminogen activator-loaded echogenic liposomes i.Arteriosclerosis, Thrombosis, and Vascular Biology, ,31 (6 ),1357-1359

Meunier, Jason M; Holland, Christy K; Porter, Tyrone M; Lindsell, Christopher J; Shaw, George J (2011. )Combination treatment with rt-PA is more effective than rt-PA alone in an in vitro human clot model. Current neurovascular research, ,8 (4 ),305-12

Kopechek, Jonathan A; Haworth, Kevin J; Raymond, Jason L; Douglas Mast, T; Perrin, Stephen R; Klegerman, Melvin E; Huang, Shaoling; Porter, Tyrone M; McPherson, David D; Holland, Christy K (2011. )Acoustic characterization of echogenic liposomes: frequency-dependent attenuation and backscatter.The Journal of the Acoustical Society of America, ,130 (5 ),3472-81

Hitchcock, Kathryn E; Ivancevich, Nikolas M; Haworth, Kevin J; Caudell Stamper, Danielle N; Vela, Deborah C; Sutton, Jonathan T; Pyne-Geithman, Gail J; Holland, Christy K (2011. )Ultrasound-enhanced rt-PA thrombolysis in an ex vivo porcine carotid artery model.Ultrasound in medicine & biology, ,37 (8 ),1240-51

Meunier, J. M.; Holland, C. K.; Porter, T. M.; Lindsell, C. J.; Shaw, G. J. (2011. )Combination treatment with rt-PA is more effective than rt-PA alone in an in vitro human clot model .Curr Neurovasc Res, ,8 (4 ),305-12

Laing, S. T.; Moody, M.; Smulevitz, B.; Kim, H.; Kee, P.; Huang, S.; Holland, C. K.; McPherson, D. D. (2011. )Ultrasound-enhanced thrombolytic effect of tissue plasminogen activator-loaded echogenic liposomes in an in vivo rabbit aorta thrombus model--brief report .Arterioscler Thromb Vasc Biol, ,31 (6 ),1357-9

Kopechek, J. A.; Haworth, K. J.; Raymond, J. L.; Douglas Mast, T.; Perrin, S. R.; Klegerman, M. E.; Huang, S.; Porter, T. M.; McPherson, D. D.; Holland, C. K. (2011. )Acoustic characterization of echogenic liposomes: frequency-dependent attenuation and backscatter .J Acoust Soc Am, ,130 (5 ),3472-81

Hitchcock, K. E.; Ivancevich, N. M.; Haworth, K. J.; Caudell Stamper, D. N.; Vela, D. C.; Sutton, J. T.; Pyne-Geithman, G. J.; Holland, C. K. (2011. )Ultrasound-enhanced rt-PA thrombolysis in an ex vivo porcine carotid artery model .Ultrasound Med Biol, ,37 (8 ),1240-51

Aronowski J.; Britton G.; Holland C.; Huang S.; Kee P.; Kim H.; McPherson D. (10-19-2010. )In vivo therapeutic gas delivery for neuroprotection with echogenic liposomes.Circulation, ,122 (16 ),1578-1587

Holland C.; Huang S.; Kim H.; Klegerman M.; Kopechek J.; Laing S.; McPherson D.; Parikh D. (06-01-2010. )Ultrasound-mediated delivery of echogenic immunoliposomes to porcine vascular smooth muscle cells in.Journal of Liposome Research, ,20 (2 ),160-167

Geng Y.; Holland C.; Huang S.; Kim H.; Klegerman M.; McPherson D.; Shelat H.; Wassler M.; Zou Y. (03-19-2010. )Liposomal modular complexes for simultaneous targeted delivery of bioactive gases and therapeutics.Journal of Controlled Release, ,142 (3 ),326-331

Clubb F.; Ge X.; Geng Y.; Herbst S.; Holland C.; Huang S.; Kim H.; Klegerman M.; Kopechek J.; Kraemer D.; McPherson D.; Moody M.; Qi J.; Shelat H.; Wassler M.; Yang C.; Zou Y. (02-01-2010. )Delivery of stem cells to porcine arterial wall with echogenic liposomes conjugated to antibodies ag.Molecular Pharmaceutics, ,7 (1 ),3-11

Datta S.; Holland C.; Shaw G. (01-01-2010. )Ultrasound-enhanced thrombolysis .Therapeutic Ultrasound: Mechanisms to Applications, ,239-260

Hitchcock, Kathryn E; Holland, Christy K (2010. )Ultrasound-assisted thrombolysis for stroke therapy: better thrombus break-up with bubbles.Stroke; a journal of cerebral circulation, ,41 (10 Suppl ),S50-3

Shaw, George J; Meunier, Jason M; Lindsell, Christopher J; Pancioli, Arthur M; Holland, Christy K (2010. )Making the right choice: optimizing rt-PA and eptifibatide lysis, an in vitro study.Thrombosis research, ,126 (4 ),e305-11

Kopechek, Jonathan A; Kim, Hyunggun; McPherson, David D; Holland, Christy K (2010. )Calibration of the 1-MHz Sonitron ultrasound system.Ultrasound in medicine & biology, ,36 (10 ),1762-6

Hitchcock, Kathryn E; Caudell, Danielle N; Sutton, Jonathan T; Klegerman, Melvin E; Vela, Deborah; Pyne-Geithman, Gail J; Abruzzo, Todd; Cyr, Peppar E P; Geng, Yong-Jian; McPherson, David D; Holland, Christy K (2010. )Ultrasound-enhanced delivery of targeted echogenic liposomes in a novel ex vivo mouse aorta model.Journal of controlled release : official journal of the Controlled Release Society, ,144 (3 ),288-95

Smith, Denise A B; Vaidya, Sampada S; Kopechek, Jonathan A; Huang, Shao-Ling; Klegerman, Melvin E; McPherson, David D; Holland, Christy K (2010. )Ultrasound-triggered release of recombinant tissue-type plasminogen activator from echogenic liposomes.Ultrasound in medicine & biology, ,36 (1 ),145-57

Smith, D. A.; Vaidya, S. S.; Kopechek, J. A.; Huang, S. L.; Klegerman, M. E.; McPherson, D. D.; Holland, C. K. (2010. )Ultrasound-triggered release of recombinant tissue-type plasminogen activator from echogenic liposomes .Ultrasound Med Biol, ,36 (1 ),145-57

Shaw, G. J.; Meunier, J. M.; Lindsell, C. J.; Pancioli, A. M.; Holland, C. K. (2010. )Making the right choice: optimizing rt-PA and eptifibatide lysis, an in vitro study .Thromb Res, ,126 (4 ),e305-11

Laing, S. T.; Kim, H.; Kopechek, J. A.; Parikh, D.; Huang, S.; Klegerman, M. E.; Holland, C. K.; McPherson, D. D. (2010. )Ultrasound-mediated delivery of echogenic immunoliposomes to porcine vascular smooth muscle cells in vivo .J Liposome Res, ,20 (2 ),160-7

Kopechek, J. A.; Kim, H.; McPherson, D. D.; Holland, C. K. (2010. )Calibration of the 1-MHz Sonitron ultrasound system .Ultrasound Med Biol, ,36 (10 ),1762-6

Klegerman, M. E.; Wassler, M.; Huang, S. L.; Zou, Y.; Kim, H.; Shelat, H. S.; Holland, C. K.; Geng, Y. J.; McPherson, D. D. (2010. )Liposomal modular complexes for simultaneous targeted delivery of bioactive gases and therapeutics .J Control Release, ,142 (3 ),326-31

Hitchcock, K. E.; Holland, C. K. (2010. )Ultrasound-assisted thrombolysis for stroke therapy: better thrombus break-up with bubbles .Stroke, ,41 (10 Suppl ),S50-3

Hitchcock, K. E.; Caudell, D. N.; Sutton, J. T.; Klegerman, M. E.; Vela, D.; Pyne-Geithman, G. J.; Abruzzo, T.; Cyr, P. E.; Geng, Y. J.; McPherson, D. D.; Holland, C. K. (2010. )Ultrasound-enhanced delivery of targeted echogenic liposomes in a novel ex vivo mouse aorta model .J Control Release, ,144 (3 ),288-95

Herbst, S. M.; Klegerman, M. E.; Kim, H.; Qi, J.; Shelat, H.; Wassler, M.; Moody, M. R.; Yang, C. M.; Ge, X.; Zou, Y.; Kopechek, J. A.; Clubb, F. J.; Kraemer, D. C.; Huang, S.; Holland, C. K.; McPherson, D. D.; Geng, Y. J. (2010. )Delivery of stem cells to porcine arterial wall with echogenic liposomes conjugated to antibodies against CD34 and intercellular adhesion molecule-1 .Mol Pharm, ,7 (1 ),3-11

Britton, G. L.; Kim, H.; Kee, P. H.; Aronowski, J.; Holland, C. K.; McPherson, D. D.; Huang, S. L. (2010. )In vivo therapeutic gas delivery for neuroprotection with echogenic liposomes .Circulation, ,122 (16 ),1578-87

Banerjee R.; Choe A.; Holland C.; Krishnamoorthy M.; Rigger D.; Roy-Chaudhury P.; Wang Y. (12-01-2009. )Vascular remodeling of arteriovenous fistula.Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, ,(PART B ),1077-1078

Holland C.; McPherson D. (11-17-2009. )Echogenic lipsomes for targeted drug delivery.Proceedings - 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009, ,755-758

Datta S.; Holland C.; Masta T.; Salgaonkar V. (07-21-2009. )Passive imaging of cavitational acoustic emissions with ultrasound arrays.AIP Conference Proceedings, ,1113 ,73-77

Burgess M.; Holland C.; Karunakaran C.; Mast T. (07-21-2009. )Role of cavitation in bulk ultrasound ablation: A histologic study.AIP Conference Proceedings, ,1113 ,43-47

Shaw, G. J.; Meunier, J. M.; Huang, S. L.; Lindsell, C. J.; McPherson, D. D.; Holland, C. K. (2009. )Ultrasound-enhanced thrombolysis with tPA-loaded echogenic liposomes .Thromb Res, ,124 (3 ),306-10

Salgaonkar, V. A.; Datta, S.; Holland, C. K.; Mast, T. D. (2009. )Passive cavitation imaging with ultrasound arrays .J Acoust Soc Am, ,126 (6 ),3071-83

Meunier, J. M.; Holland, C. K.; Pancioli, A. M.; Lindsell, C. J.; Shaw, G. J. (2009. )Effect of low frequency ultrasound on combined rt-PA and eptifibatide thrombolysis in human clots .Thromb Res, ,123 (3 ),528-36

Holland, C. K.; McPherson, D. D. (2009. )Echogenic Lipsomes for Targeted Drug Delivery .Proc IEEE Int Symp Biomed Imaging, ,2009 (3 ),755-758

Salgaonkar, Vasant A; Datta, Saurabh; Holland, Christy K; Mast, T Douglas (2009. )Passive cavitation imaging with ultrasound arrays.The Journal of the Acoustical Society of America, ,126 (6 ),3071-83

Shaw, George J; Meunier, Jason M; Huang, Shao-Ling; Lindsell, Christopher J; McPherson, David D; Holland, Christy K (2009. )Ultrasound-enhanced thrombolysis with tPA-loaded echogenic liposomes.Thrombosis research, ,124 (3 ),306-10

Holland, Christy K; McPherson, David D (2009. )ECHOGENIC LIPSOMES FOR TARGETED DRUG DELIVERY. Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging, ,2009 ,755-758

Meunier, Jason M; Holland, Christy K; Pancioli, Arthur M; Lindsell, Christopher J; Shaw, George J (2009. )Effect of low frequency ultrasound on combined rt-PA and eptifibatide thrombolysis in human clots.Thrombosis research, ,123 (3 ),528-36

Abruzzo T.; Holland C.; Huang S.; Kee P.; Kopechek J.; MacDonald R.; McPherson D.; Smith D.; Wang B. (12-01-2008. )Synthesis, acoustic stability, and pharmacologic activities of papaverine-loaded echogenic liposomes.Journal of Liposome Research, ,18 (4 ),263-277

Boyce S.; Choe A.; Espy-Wilson C.; Holland C.; Tiede M.; Zhou X. (06-17-2008. )A magnetic resonance imaging-based articulatory and acoustic study of "retroflex" and "bunched" Amer.Journal of the Acoustical Society of America, ,123 (6 ),4466-4481

Averkiou M.; Brayman A.; Everbach E.; Holland C.; Miller D.; Wible J.; Wu J. (01-01-2008. )Bioeffects considerations for diagnostic ultrasound contrast agents.Journal of Ultrasound in Medicine, ,27 (4 ),611-632

Abbott J.; Abramowicz J.; Averkiou M.; Bailey M.; Barnett S.; Brayman A.; Carson P.; Carstensen E.; Church C.; Dalecki D.; Deng C.; Duck F.; Dunn F.; Edmonds P.; Everbach E.; Fowlkes J.; Frizzell L.; Greenleaf J.; Harris G.; Herman B.; Holland C.; Hynynen K.; Merritt C.; Miller D.; Nyborg W.; O'Brien W.; Salvesen K.; Sanghvi N.; Siddiqi T.; Simpson D.; Stratmeyer M.; Thomenius K.; Wible J.; Wu J.; Zachary J.; Ziskin M. (01-01-2008. )American Institute of Ultrasound in Medicine consensus report on potential bioeffects of diagnostic .Journal of Ultrasound in Medicine, ,27 (4 ),503-515

Kopechek, Jonathan A; Abruzzo, Todd M; Wang, Boyu; Chrzanowski, Stephen M; Smith, Denise A B; Kee, Patrick H; Huang, Shaoling; Collier, Joel H; McPherson, David D; Holland, Christy K (2008. )Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, ,27 (11 ),1597-606

Shaw, George J; Meunier, Jason M; Lindsell, Christopher J; Holland, Christy K (2008. )Tissue plasminogen activator concentration dependence of 120 kHz ultrasound-enhanced thrombolysis.Ultrasound in medicine & biology, ,34 (11 ),1783-92

Ammi, Azzdine Y; Mast, T Douglas; Huang, I-Hua; Abruzzo, Todd A; Coussios, Constantin-C; Shaw, George J; Holland, Christy K (2008. )Characterization of ultrasound propagation through ex-vivo human temporal bone.Ultrasound in medicine & biology, ,34 (10 ),1578-89

Mast, T Douglas; Salgaonkar, Vasant A; Karunakaran, Chandrapriya; Besse, John A; Datta, Saurabh; Holland, Christy K (2008. )Acoustic emissions during 3.1 MHz ultrasound bulk ablation in vitro.Ultrasound in medicine & biology, ,34 (9 ),1434-48

Datta, Saurabh; Coussios, Constantin-C; Ammi, Azzdine Y; Mast, T Douglas; de Courten-Myers, Gabrielle M; Holland, Christy K (2008. )Ultrasound-enhanced thrombolysis using Definity as a cavitation nucleation agent.Ultrasound in medicine & biology, ,34 (9 ),1421-33

Wang, Yang; Krishnamoorthy, Mahesh; Banerjee, Rupak; Zhang, Jianhua; Rudich, Steven; Holland, Christy; Arend, Lois; Roy-Chaudhury, Prabir (2008. )Venous stenosis in a pig arteriovenous fistula model--anatomy, mechanisms and cellular phenotypes.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, ,23 (2 ),525-33

Holland, Christy K; Vaidya, Sampada S; Datta, Saurabh; Coussios, Constantin-C; Shaw, George J (2008. )Ultrasound-enhanced tissue plasminogen activator thrombolysis in an in vitro porcine clot model.Thrombosis research, ,121 (5 ),663-73

Zhou, X.; Espy-Wilson, C. Y.; Boyce, S.; Tiede, M.; Holland, C.; Choe, A. (2008. )A magnetic resonance imaging-based articulatory and acoustic study of "retroflex" and "bunched" American English /r .J Acoust Soc Am, ,123 (6 ),4466-81

Wang, Y.; Krishnamoorthy, M.; Banerjee, R.; Zhang, J.; Rudich, S.; Holland, C.; Arend, L.; Roy-Chaudhury, P. (2008. )Venous stenosis in a pig arteriovenous fistula model--anatomy, mechanisms and cellular phenotypes .Nephrol Dial Transplant, ,23 (2 ),525-33

Shaw, G. J.; Meunier, J. M.; Lindsell, C. J.; Holland, C. K. (2008. )Tissue plasminogen activator concentration dependence of 120 kHz ultrasound-enhanced thrombolysis .Ultrasound Med Biol, ,34 (11 ),1783-92

Miller, D. L.; Averkiou, M. A.; Brayman, A. A.; Everbach, E. C.; Holland, C. K.; Wible, J. H., Jr.; Wu, J. (2008. )Bioeffects considerations for diagnostic ultrasound contrast agents .J Ultrasound Med, ,27 (4 ),611-32; quiz 633-6

Mast, T. D.; Salgaonkar, V. A.; Karunakaran, C.; Besse, J. A.; Datta, S.; Holland, C. K. (2008. )Acoustic emissions during 3.1 MHz ultrasound bulk ablation in vitro .Ultrasound Med Biol, ,34 (9 ),1434-48

Kopechek, J. A.; Abruzzo, T. M.; Wang, B.; Chrzanowski, S. M.; Smith, D. A.; Kee, P. H.; Huang, S.; Collier, J. H.; McPherson, D. D.; Holland, C. K. (2008. )Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes .J Ultrasound Med, ,27 (11 ),1597-606

Kee, P. H.; Abruzzo, T. A.; Smith, D. A.; Kopechek, J. A.; Wang, B.; Huang, S. L.; MacDonald, R. C.; Holland, C. K.; McPherson, D. D. (2008. )Synthesis, acoustic stability, and pharmacologic activities of papaverine-loaded echogenic liposomes for ultrasound controlled drug delivery .J Liposome Res, ,18 (4 ),263-77

Holland, C. K.; Vaidya, S. S.; Datta, S.; Coussios, C. C.; Shaw, G. J. (2008. )Ultrasound-enhanced tissue plasminogen activator thrombolysis in an in vitro porcine clot model .Thromb Res, ,121 (5 ),663-73

Datta, S.; Coussios, C. C.; Ammi, A. Y.; Mast, T. D.; de Courten-Myers, G. M.; Holland, C. K. (2008. )Ultrasound-enhanced thrombolysis using Definity as a cavitation nucleation agent .Ultrasound Med Biol, ,34 (9 ),1421-33

Ammi, A. Y.; Mast, T. D.; Huang, I. H.; Abruzzo, T. A.; Coussios, C. C.; Shaw, G. J.; Holland, C. K. (2008. )Characterization of ultrasound propagation through ex-vivo human temporal bone .Ultrasound Med Biol, ,34 (10 ),1578-89

Besse J.; Datta S.; Holland C.; Karunakaran C.; Mast T.; Salgaonkar V. (09-24-2007. )Measurements of cavitation dose, echogenicity, and temperature during ultrasound ablation.AIP Conference Proceedings, ,911 ,335-341

Besse J.; Datta S.; Heinlein G.; Holland C.; Karunakaran C.; Mast T.; Salgaonkar V. (08-31-2007. )Image-guided Ex vivo liver ablation by unfocused ultrasound using passive cavitation detection.Progress in Biomedical Optics and Imaging - Proceedings of SPIE, ,6440 ,

Holland C.; Huang S.; Klegerman M.; McPherson D.; Tiukinhoy-Laing S. (03-23-2007. )Ultrasound-facilitated thrombolysis using tissue-plasminogen activator-loaded echogenic liposomes.Thrombosis Research, ,119 (6 ),777-784

Holland C. (01-01-2007. )Online review facilitates rapid publishing.Ultrasound in Medicine and Biology, ,33 (1 ),1-2

Tiukinhoy-Laing, S. D.; Huang, S.; Klegerman, M.; Holland, C. K.; McPherson, D. D. (2007. )Ultrasound-facilitated thrombolysis using tissue-plasminogen activator-loaded echogenic liposomes .Thromb Res, ,119 (6 ),777-84

Smith, D. A.; Porter, T. M.; Martinez, J.; Huang, S.; MacDonald, R. C.; McPherson, D. D.; Holland, C. K. (2007. )Destruction thresholds of echogenic liposomes with clinical diagnostic ultrasound .Ultrasound Med Biol, ,33 (5 ),797-809

Shaw, G. J.; Dhamija, A.; Bavani, N.; Wagner, K. R.; Holland, C. K. (2007. )Arrhenius temperature dependence of in vitro tissue plasminogen activator thrombolysis .Phys Med Biol, ,52 (11 ),2953-67

Nahirnyak, V.; Mast, T. D.; Holland, C. K. (2007. )Ultrasound-induced thermal elevation in clotted blood and cranial bone .Ultrasound Med Biol, ,33 (8 ),1285-95

Meunier, J. M.; Holland, C. K.; Lindsell, C. J.; Shaw, G. J. (2007. )Duty cycle dependence of ultrasound enhanced thrombolysis in a human clot model .Ultrasound Med Biol, ,33 (4 ),576-83

Nahirnyak, Volodymyr; Mast, T Douglas; Holland, Christy K (2007. )Ultrasound-induced thermal elevation in clotted blood and cranial bone.Ultrasound in medicine & biology, ,33 (8 ),1285-95

Shaw, George J; Dhamija, Ashima; Bavani, Nazli; Wagner, Kenneth R; Holland, Christy K (2007. )Arrhenius temperature dependence of in vitro tissue plasminogen activator thrombolysis.Physics in medicine and biology, ,52 (11 ),2953-67

Smith, Denise A B; Porter, Tyrone M; Martinez, Janet; Huang, Shaoling; MacDonald, Robert C; McPherson, David D; Holland, Christy K (2007. )Destruction thresholds of echogenic liposomes with clinical diagnostic ultrasound.Ultrasound in medicine & biology, ,33 (5 ),797-809

Meunier, Jason M; Holland, Christy K; Lindsell, Christopher J; Shaw, George J (2007. )Duty cycle dependence of ultrasound enhanced thrombolysis in a human clot model.Ultrasound in medicine & biology, ,33 (4 ),576-83

Adams J.; Babcock D.; Holland C.; Racadio J.; Toepfer N. (03-01-2006. )Aortic pseudothrombus: A sonographic artifact in the abdominal aorta.Journal of Diagnostic Medical Sonography, ,22 (2 ),131-134

Porter, Tyrone M; Smith, Denise A B; Holland, Christy K (2006. )Acoustic techniques for assessing the Optison destruction threshold. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, ,25 (12 ),1519-29

Wright, Stewart W; Lindsell, Christopher J; Hinckley, William R; Williams, Annette; Holland, Carolyn; Lewis, Christopher H; Heimburger, Gail (2006. )High fidelity medical simulation in the difficult environment of a helicopter: feasibility, self-efficacy and cost.BMC medical education, ,6 ,49

Datta, Saurabh; Coussios, Constantin-C; McAdory, Louis E; Tan, Jun; Porter, Tyrone; De Courten-Myers, Gabrielle; Holland, Christy K (2006. )Correlation of cavitation with ultrasound enhancement of thrombolysis.Ultrasound in medicine & biology, ,32 (8 ),1257-67

Nahirnyak, Volodymyr M; Yoon, Suk Wang; Holland, Christy K (2006. )Acousto-mechanical and thermal properties of clotted blood. The Journal of the Acoustical Society of America, ,119 (6 ),3766-72

More, Shashikant R; Lim, Teik C; Li, Mingfeng; Holland, Christy K; Boyce, Suzanne E; Lee, Jing-Huei (2006. )Acoustic noise characteristics of a 4 Telsa MRI scanner.Journal of magnetic resonance imaging : JMRI, ,23 (3 ),388-97

Wright, S. W.; Lindsell, C. J.; Hinckley, W. R.; Williams, A.; Holland, C.; Lewis, C. H.; Heimburger, G. (2006. )High fidelity medical simulation in the difficult environment of a helicopter: feasibility, self-efficacy and cost .BMC Med Educ, ,6 (4 ),49

Porter, T. M.; Smith, D. A.; Holland, C. K. (2006. )Acoustic techniques for assessing the Optison destruction threshold .J Ultrasound Med, ,25 (12 ),1519-29

Nahirnyak, V. M.; Yoon, S. W.; Holland, C. K. (2006. )Acousto-mechanical and thermal properties of clotted blood .J Acoust Soc Am, ,119 (6 ),3766-72

More, S. R.; Lim, T. C.; Li, M.; Holland, C. K.; Boyce, S. E.; Lee, J. H. (2006. )Acoustic noise characteristics of a 4 Telsa MRI scanner .J Magn Reson Imaging, ,23 (3 ),388-97

Datta, S.; Coussios, C. C.; McAdory, L. E.; Tan, J.; Porter, T.; De Courten-Myers, G.; Holland, C. K. (2006. )Correlation of cavitation with ultrasound enhancement of thrombolysis .Ultrasound Med Biol, ,32 (8 ),1257-67

Cheng J.; Holland C.; Shaw G. (07-01-2005. )In vitro microscopic imaging of enhanced thrombolysis with 120-kHz ultrasound in a human clot model.Acoustic Research Letters Online, ,6 (3 ),25-29

Cheng J.; Holland C.; Shaw G. (01-01-2005. )In vitro microscopic imaging of enhanced thrombolysis with 120-kHz ultrasound in a human clot model.Acoustic Research Letters Online, ,6 (1 ),25-29

Everbach E.; Holland C. (01-01-2005. )Guest editorial: Sono et Gravitas - The legacy of Robert Edmund Apfel.Acoustic Research Letters Online, ,6 (3 ),

Cheng, J. Y.; Shaw, G. J.; Holland, C. K. (2005. )In vitro microscopic imaging of enhanced thrombolysis with 120-kHz ultrasound in a human clot model .Acoust Res Lett Online, ,6 (1 ),25-29

Cheng, Jason Y; Shaw, George J; Holland, Christy K (2005. )In vitro microscopic imaging of enhanced thrombolysis with 120-kHz ultrasound in a human clot model.Acoustics research letters online : ARLO, ,6 (1 ),25-29

Coussios, Constantin-C; Holland, Christy K; Jakubowska, Ludwika; Huang, Shao-Ling; MacDonald, Robert C; Nagaraj, Ashwin; McPherson, David D (2004. )In vitro characterization of liposomes and Optison by acoustic scattering at 3.5 MHz.Ultrasound in medicine & biology, ,30 (2 ),181-90

Coussios, C. C.; Holland, C. K.; Jakubowska, L.; Huang, S. L.; MacDonald, R. C.; Nagaraj, A.; McPherson, D. D. (2004. )In vitro characterization of liposomes and Optison by acoustic scattering at 3.5 MHz .Ultrasound Med Biol, ,30 (2 ),181-90

Holland C.; McPherson D. (05-07-2003. )Seizing the science of ultrasound: Beyond imaging and into physiology and therapeutics.Journal of the American College of Cardiology, ,41 (9 ),1628-1630

Holland C.; Taylor C. (01-01-2003. )Kenneth J. Taylor, MD, PhD, FACP, 1939-2003, pioneer of diagnostic ultrasound imaging.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, ,22 (6 ),663-664

Taylor, C. R.; Holland, C. K. (2003. )Kenneth J. Taylor, MD, PhD, FACP, 1939-2003, pioneer of diagnostic ultrasound imaging .J Ultrasound Med, ,22 (6 ),663-4

McPherson, D. D.; Holland, C. K. (2003. )Seizing the science of ultrasound: beyond imaging and into physiology and therapeutics .J Am Coll Cardiol, ,41 (9 ),1628-30

Fowlkes J.; Holland C.; Kremkau F. (01-01-2000. )Mechanical bioeffects from diagnostic ultrasound: AIUM consensus statements .Journal of Ultrasound in Medicine, ,19 (2 ),68-168

Fowlkes J.; Holland C. (01-01-2000. )Mechanical bioeffects from diagnostic ultrasound: AIUM consensus statements. American Institute of U.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, ,19 (2 ),69-72

Fowlkes, J. B.; Holland, C. K. (2000. )Mechanical bioeffects from diagnostic ultrasound: AIUM consensus statements. American Institute of Ultrasound in Medicine .J Ultrasound Med, ,19 (2 ),69-72

Ouanounou, S.; Tomsick, T. A.; Heitsman, C.; Holland, C. K. (1999. )Cavernous sinus and inferior petrosal sinus flow signal on three-dimensional time-of-flight MR angiography .AJNR Am J Neuroradiol, ,20 (8 ),1476-81

Ouanounou, S; Tomsick, T A; Heitsman, C; Holland, C K (1999. )Cavernous sinus and inferior petrosal sinus flow signal on three-dimensional time-of-flight MR angiography. AJNR. American journal of neuroradiology, ,20 (8 ),1476-81

Holland, C K; Brown, J M; Scoutt, L M; Taylor, K J (1998. )Lower extremity volumetric arterial blood flow in normal subjects. Ultrasound in medicine & biology, ,24 (8 ),1079-86

Holland, C. K.; Brown, J. M.; Scoutt, L. M.; Taylor, K. J. (1998. )Lower extremity volumetric arterial blood flow in normal subjects .Ultrasound Med Biol, ,24 (8 ),1079-86

Apfel R.; Deng C.; Holland C.; Xu Q. (01-01-1996. )Inertial cavitation produced by pulsed ultrasound in controlled host media.Journal of the Acoustical Society of America, ,100 (2 I ),1199-1208

Apfel R.; Deng C.; Holland C.; Xu Q. (01-01-1996. )In vitro measurements of inertial cavitation thresholds in human blood.Ultrasound in Medicine and Biology, ,22 (7 ),939-948

Holland, C. K.; Deng, C. X.; Apfel, R. E.; Alderman, J. L.; Fernandez, L. A.; Taylor, K. J. (1996. )Direct evidence of cavitation in vivo from diagnostic ultrasound .Ultrasound Med Biol, ,22 (7 ),917-25

Holland, C. K.; Clancy, M. J.; Taylor, K. J.; Alderman, J. L.; Purushothaman, K.; McCauley, T. R. (1996. )Volumetric flow estimation in vivo and in vitro using pulsed-Doppler ultrasound .Ultrasound Med Biol, ,22 (5 ),591-603

Deng, C. X.; Xu, Q.; Apfel, R. E.; Holland, C. K. (1996. )In vitro measurements of inertial cavitation thresholds in human blood .Ultrasound Med Biol, ,22 (7 ),939-48

Deng, C. X.; Xu, Q.; Apfel, R. E.; Holland, C. K. (1996. )Inertial cavitation produced by pulsed ultrasound in controlled host media .J Acoust Soc Am, ,100 (2 Pt 1 ),1199-208

Holland, C K; Deng, C X; Apfel, R E; Alderman, J L; Fernandez, L A; Taylor, K J (1996. )Direct evidence of cavitation in vivo from diagnostic ultrasound. Ultrasound in medicine & biology, ,22 (7 ),917-25

Holland, C K; Clancy, M J; Taylor, K J; Alderman, J L; Purushothaman, K; McCauley, T R (1996. )Volumetric flow estimation in vivo and in vitro using pulsed-Doppler ultrasound. Ultrasound in medicine & biology, ,22 (5 ),591-603

Barton J.; Brown J.; Hammers L.; Holland C.; Pellerito J.; Scoutt L.; Taylor K. (01-01-1995. )Quantitative Doppler assessment of acute scrotal inflammation.Radiology, ,197 (2 ),427-431

Hammers L.; Holland C.; Quedens-Case C.; Reinhold C.; Taylor C.; Taylor K. (01-01-1995. )Characterization of focal hepatic lesions with duplex sonography: Findings in 198 patients.American Journal of Roentgenology, ,164 (5 ),1131-1135

Gore J.; Holland C.; McCauley T.; Pena C.; Price T. (01-01-1995. )Validation of volume flow measurements with cine phase?contrast MR imaging for peripheral arterial w.Journal of Magnetic Resonance Imaging, ,5 (6 ),663-668

Reinhold, C.; Hammers, L.; Taylor, C. R.; Quedens-Case, C. L.; Holland, C. K.; Taylor, K. J. (1995. )Characterization of focal hepatic lesions with duplex sonography: findings in 198 patients .AJR Am J Roentgenol, ,164 (5 ),1131-5

McCauley, T. R.; Pena, C. S.; Holland, C. K.; Price, T. B.; Gore, J. C. (1995. )Validation of volume flow measurements with cine phase-contrast MR imaging for peripheral arterial waveforms .J Magn Reson Imaging, ,5 (6 ),663-8

Brown, J. M.; Hammers, L. W.; Barton, J. W.; Holland, C. K.; Scoutt, L. M.; Pellerito, J. S.; Taylor, K. J. (1995. )Quantitative Doppler assessment of acute scrotal inflammation .Radiology, ,197 (2 ),427-31

Holland C.; Taylor K. (01-01-1993. )Blood flow quantitation: waveform analysis, volume measurement, tumor flow, and the role of color im .Clinics in diagnostic ultrasound, ,28 ,125-139

Case C.; Dillon E.; Holland C.; Ramos I.; Taylor K. (01-01-1993. )Endovaginal pulsed and color doppler in first-trimester pregnancy.Ultrasound in Medicine and Biology, ,19 (7 ),517-525

Case C.; Dillon E.; Holland C.; Ramos I.; Taylor K. (01-01-1993. )Endovaginal US and Doppler findings after first-trimester abortion.Radiology, ,186 (1 ),87-91

Holland, C. K.; Taylor, K. J. (1993. )Blood flow quantitation: waveform analysis, volume measurement, tumor flow, and the role of color imaging .Clin Diagn Ultrasound, ,28 (2 ),125-39

Holland, C. K. (1993. )An ethnographic study of nursing culture as an exploration for determining the existence of a system of ritual .J Adv Nurs, ,18 (9 ),1461-70

Dillon, E. H.; Case, C. Q.; Ramos, I. M.; Holland, C. K.; Taylor, K. J. (1993. )Endovaginal pulsed and color Doppler in first-trimester pregnancy .Ultrasound Med Biol, ,19 (7 ),517-25

Dillon, E. H.; Case, C. Q.; Ramos, I. M.; Holland, C. K.; Taylor, K. J. (1993. )Endovaginal US and Doppler findings after first-trimester abortion .Radiology, ,186 (1 ),87-91

Apfel R.; Church C.; Crum L.; Dinno M.; Holland C.; Madanshetty S.; Roy R. (01-01-1992. )Acoustic cavitation produced by microsecond pulses of ultrasound: A discussion of some selected resu.Journal of the Acoustical Society of America, ,91 (2 ),1113-1119

Apfel R.; Crum L.; Holland C.; Roy R. (01-01-1992. )In Vitro Detection of Cavitation Induced by a Diagnostic Ultrasound System.IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, ,39 (1 ),95-101

Holland, C. K.; Roy, R. A.; Apfel, R. E.; Crum, L. A. (1992. )In vitro detection of cavitation induced by a diagnostic ultrasound system .IEEE Trans Ultrason Ferroelectr Freq Control, ,39 (1 ),95-101

Crum, L. A.; Roy, R. A.; Dinno, M. A.; Church, C. C.; Apfel, R. E.; Holland, C. K.; Madanshetty, S. I. (1992. )Acoustic cavitation produced by microsecond pulses of ultrasound: a discussion of some selected results .J Acoust Soc Am, ,91 (2 ),1113-9

Apfel R.; Holland C. (01-01-1991. )Gauging the likelihood of cavitation from short-pulse, low-duty cycle diagnostic ultrasound.Ultrasound in Medicine and Biology, ,17 (2 ),179-185

Apfel, R. E.; Holland, C. K. (1991. )Gauging the likelihood of cavitation from short-pulse, low-duty cycle diagnostic ultrasound .Ultrasound Med Biol, ,17 (2 ),179-85

Apfel R.; Holland C. (01-01-1990. )Thresholds for transient cavitation produced by pulsed ultrasound in a controlled nuclei environment.Journal of the Acoustical Society of America, ,88 (5 ),2059-2069

Holland, C. K.; Apfel, R. E. (1990. )Thresholds for transient cavitation produced by pulsed ultrasound in a controlled nuclei environment .J Acoust Soc Am, ,88 (5 ),2059-69

Apfel R.; Holland C. (01-01-1989. )An Improved Theory for the Prediction of Microcavitation Thresholds.IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, ,36 (2 ),204-208

Holland C. (01-01-1989. )Thresholds of transient cavitation produced by pulsed ultrasound in a controlled nuclei environment.Journal of the Acoustical Society of America, ,86 (2 ),844

Holland, C. K.; Apfel, R. E. (1989. )An improved theory for the prediction of microcavitation thresholds .IEEE Trans Ultrason Ferroelectr Freq Control, ,36 (2 ),204-8

Apfel R.; Atchley A.; Frizzell L.; Holland C.; Madanshetty S.; Roy R. (01-01-1988. )Thresholds for cavitation produced in water by pulsed ultrasound.Ultrasonics, ,26 (5 ),280-285

Atchley, A. A.; Frizzell, L. A.; Apfel, R. E.; Holland, C. K.; Madanshetty, S.; Roy, R. A. (1988. )Thresholds for cavitation produced in water by pulsed ultrasound .Ultrasonics, ,26 (5 ),280-5

Book Chapter

J. B. Fowlkes and C. K. Holland (2010 )Biologic effects and safety Diagnostic Ultrasound, 4th Ed. St. Louis, MO,Mosby

C. K. Holland and J. B. Fowlkes (2004 )Biologic effects and safety Diagnostic Ultrasound, 3rd Ed. .St. Louis, MO,Mosby

AIUM (2000 )Mechanical Bioeffects from Diagnostic Ultrasound: AIUM Consensus Statements J. Ultrasound Med. (pp. 68-168).

C. K. Holland, T. A. Siddiqi (1999 )Mechanical Bioeffects of Diagnostic Ultrasound The Safe Use of Ultrasound in Medical Diagnosis .(pp. 44-55).London, England,British Medical Ultrasound Society/British Institute of Radiology

C. K. Holland (1998 )Cavitation produced by diagnostic ultrasound pulses: Can it occur in vivo? Progress in Obstetric and Gynecological Sonography Series: Safety of Diagnostic Ultrasound .Pearl River, New York ,Parthenon Publishing Group

J. B. Fowlkes and C. K. Holland (1998 )Biologic effects and safety Diagnostic Ultrasound, 2nd Ed. .St. Louis, MO,Mosby

C. K. Holland (1995 )Ultrasound Bioeffects: The Mechanical and Thermal Indices Medical CT and Ultrasound: Current Technology and Applications .(pp. 211-228).Madison, WI,Advanced Medical Publishing

C. K. Holland and K. J. W. Taylor (1993 )Blood flow quantitation: Waveform analysis, volume measurement, tumor flow and the role of color imaging Advances in ultrasound techniques and instrumentation .(pp. 125-139).Livingstone, New York ,Churchill

C. K. Holland, G. J. Shaw and S. Datta (2011 )Ultrasound-Enhanced Thrombolysis Therapeutic Ultrasound: Mechanisms to Applications .New York,Nova Science

K. B. Bader, G. Bouchoux, C. K. Holland (2015 )Sonothrombolysis Therapeutic Ultrasound .New York,Springer

J. B. Fowlkes and C. K. Holland (2017 )Biologic effects and safety Diagnostic Ultrasound, 5th Ed. Philadelphia, PA,Elsevier

Presentations

Invited Presentations

C. K. Holland (10-04-2010. )Targeting therapeutics with ultrasound .Mackay Memorial Hospital, Tamshui branch , Taipei county, Taiwan.

C. K. Holland (10-04-2010. )Submission of papers to Ultrasound in Medicine and Biology: A Round table discussion .National Taiwan University, Taipei, Taiwan.

C. K. Holland (11-02-2010. )Ultrasound-mediated drug delivery using echogenic liposomes .Taiwan Society of Ultrasound in Medicine , Taipei, Taiwan.

C. K. Holland (10-01-2010. )Expanding the impact of therapeutic ultrasound .National Yang-Ming University , Institute of Biomedical Engineering.

C. K. Holland (09-16-2010. )Ultrasound-mediated drug delivery using echogenic liposomes .Cardiovascular Center of Excellence Seminar,College of Medicine, University of Cincinnati , Cincinnati, OH.

C. K. Holland (09-14-2010. )Ultrasound-mediated drug delivery using echogenic liposomes .Department of Physics and the National Center for Physical Acoustics Seminar, University of Mississippi , Mississippi.

C. K. Holland (09-14-2010. )The submission and review process of academic publishing .National Center for Physical Acoustics, University of Mississippi, Mississippi.

K. E. Hitchcock, N. M. Ivancevich, K. J. Haworth, D. N. Caudell Stamper, D. Vela, G. J. Pyne-Geithman, C. K. Holland (2010. )Ultrasound-enhanced thrombolysis in an ex vivo porcine carotid artery model .J. Acoust. Soc. Am. ,

C. K. Holland (2010. )Expanding the impact of therapeutic ultrasound .J. Ultrasound Med. 29:S69 ,

C. K. Holland, J. A. Kopechek, K. E. Hitchcock, D. Caudell, G. Pyne-Geithman, S. Huang, D. D. McPherson (01-21-2010. )Ultrasound-mediated drug delivery using echogenic liposomes .15th European Symposium on Ultrasound Contrast Imaging, Rotterdam, Netherlands.

C. K. Holland (09-30-2009. )Sonothrombolysis: In vitro, Ex vivo, In vivo .Third Autumn School on Therapeutic Ultrasound, Cargese , Corsica, France .

C. K. Holland (08-30-2009. )Ultrasound enhanced thrombolysis .Ultrasound Med Biol 35(8S):S33 ,

C. K. Holland (08-31-2009. )Ultrasound mediated drug delivery .Ultrasound Med Biol 35(8S):S8 ,

C. K. Holland (04-05-2009. )Ultrasound thrombolysis and drug delivery .J Ultrasound Med 28(3):S114,

C. K. Holland (11-23-2008. )Ultrasound-enhanced thrombolysis .Student chapter of the Biomedical Engineering Society, University of Cincinnati , Cincinnati, OH.

C. K. Holland, D. A. Smith, J. M. Meunier, G. J. Shaw, S. L. Huang, D. D. McPherson (2008. )Targeting thrombolysis with ultrasound-sensitive liposomes .Int. J. Stroke 3(Suppl 1):36 ,

C. K. Holland, A. Y. Ammi, J. M. Meunier, G. J. Shaw, K. R. Wagner (2008. )Ultrasound thrombolysis .Int. J. Stroke 3(Suppl 1):437 ,

C. K. Holland (2008. )Interactions between clot and ultrasound: Better blood clot break-up with bubbles .Cerebrovasc Dis 26:8 ,

C. K. Holland and D. D. McPherson (2008. )Echogenic liposomes for image-guided drug delivery .J. Acoust. Soc. Am. 123:3112 ,

C. K. Holland (06-24-2008. )Ultrasound contrast in sonothrombolysis .Stroke Team Seminar, Neurology Dept., University of Cincinnati , Cincinnati, OH.

C. K. Holland (03-15-2008. )Ultrasound contrast in sonothrombolysis .J Ultrasound Med 27(3):S74,

C. K. Holland (10-28-2007. )The role of cavitation in ultrasound-enhanced membrane permeability and drug activity .IEEE Ultrasonics Symposium, New York.

C. K. Holland (10-26-2007. )Better Blood Clot Break up with Bubbles: Ultrasound Enhanced Thrombolysis .Division of Nephrology and Hypertension Seminar, University of Cincinnati , Cincinnati, OH.

C. K. Holland (10-25-2007. )The role of cavitation in ultrasound-enhanced membrane permeability and drug activity .National Heart Lung and Blood Institute, National Institutes of Health,

C. K. Holland (10-11-2007. )Better Blood Clot Breakup With Bubbles: Ultrasound-Enhanced Thrombolysis .Ohio State University Biomedical Engineering Research Seminar, Columbus, OH.

C. K. Holland (2007. )Better Blood Clot Breakup With Bubbles: Ultrasound-Enhanced Thrombolysis .J Ultrasound Med 26:S57 ,

C. K. Holland (06-01-2006. )The evolution of contrast agents: From therapeutics to diagnostics .Department of Physics, SungKyunKwan University, Seoul, Korea .

C. K. Holland (Bad Format: 20060431. )Ultrasound-assisted drug delivery and thrombolysis .Medison Inc., Seoul, Korea .

C. Holland, T. Porter, D. McPherson (05-30-2006. )Ultrasound-assisted drug delivery and thrombolysis .World Federation of Ultrasound in Medicine and Biology Meeting , Seoul, Korea.

C. K. Holland (05-23-2006. )The evolution of contrast agents: From therapeutics to diagnostics .The Leading Edge Symposium , Atlantic City, NJ .

C. K. Holland (04-26-2006. )The evolution of contrast agents: From therapeutics to diagnostics .Dept. of Systems Biology and Physiology, University of Cincinnati , Cincinnati, OH.

C. K. Holland (03-30-2006. )The evolution of contrast agents: From therapeutics to diagnostics .Department of Radiology, University of Texas Health Science Center, San Antonio, Texas.

C. K. Holland (01-27-2006. )The evolution of contrast agents: From therapeutics to diagnostics .Vanderbilt University Institute of Imaging Science, Nashville, TN.

C. K. Holland (11-03-2005. )The evolution of contrast agents: From therapeutics to diagnostics .Memphis BioImaging Symposium, Memphis, TN.

C. K. Holland (07-04-2005. )Ultrasound enhancement of membrane permeability and drug actvity .Mayneord Phillips Summer School on Ultrasound and Other Minimally Invasive Therapies, Oxford University , Oxford, UK .

C. K. Holland (06-23-2005. )BME Research Opportunities .Summer Surgery Experience at UC program, Cincinnati, OH.

C. K. Holland (06-18-2005. )Risk and Safety .American Institute of Ultrasound in Medicine Preconvention Course on Diagnostic Ultrasound Principles and Instruments: Fundamentals and Advances ,

C. K. Holland (03-23-2005. )Ultrasound-assisted Thrombolysis for Stroke Therapy .Department of Mechanical Engineering Distinguished Lecture Series, Univeristy of Texas , Austin, TX.

C. K. Holland (2004. )Ultrasound-assisted drug delivery: From bioeffects to therapeutic benefit .J Ultrasound Med., 23:S84 ,

C. K. Holland (2004. )Biomedical Engineering: A platform for research and innovation in ultrasound .J Acoust. Soc. Am., 115, 2563 ,

C. K. Holland (2004. )Robert Apfel’s contribution to clinical diagnostic ultrasound: The mechanical index .J Acoust. Soc. Am., 115, 2418 ,

C. K. Holland (10-29-2003. )Ultrasound-Assisted Thrombolysis for Stroke Therapy .Biomedical Engineering Research Seminar Series, Rensselaer Polytechnic Institute ,

C. K. Holland, R. A. Roy, P. W. Biddinger, C. J. Disimile, C. Cawood (09-06-2001. )Cavitation mediated rat lung bioeffects from diagnostic ultrasound .International Congress on Acoustics , Rome, Italy .

C. K. Holland (2001. )Bioeffects in Tissues with Gas Bodies .AIUM Categorical Course, J. Ultrasound in Med. ,

C. K. Holland (12-07-2000. )Bioeffects in the Lung and Intestine .Thirty-Second Annual Meeting of the British Medical Ultrasound Society , Eastbourne, U.K. .

C. K. Holland (12-07-2000. )The Mechanical Index – An Overview .Thirty-Second Annual Meeting of the British Medical Ultrasound Society , Eastbourne, U.K. .

C. K. Holland (05-01-2000. )The Safety of Diagnostic Ultrasound .Society for Pediatric Radiology Annual Meeting , Ft. Meyers, FL .

C. K. Holland (11-17-1999. )Assessing Arterial Stenosis by Tracking Turbulence .Condensed Matter Seminar, Dept. of Physics, University of Cincinnati , Cincinnati, OH.

C. K. Holland (11-16-1999. )Mechanical Bioeffects of Diagnostic Ultrasound in Lung and Intestine .Dept. of Aerospace Engineering & Engineering Mechanics, Introduction to Biomechanics, 20-251-627 ,

C. K. Holland (10-19-1999. )What you should know about Doppler Artifacts and Bioeffects .Midwest Society for Pediatric Radiology Annual Meeting , Cincinnati, OH.

C. K. Holland, R. E. Apfel (1999. )Fundamentals of the Mechanical Index and Caveats in its Application .J. Acoust. Soc. Am. 105, No.2, Pt. 2, ,

C. K. Holland (12-10-1997. )Diagnosing Arterial Disease with Turbulence .Department of Surgery Noon Conference, University of Cincinnati , Cincinnati, OH.

C. K. Holland (07-16-1997. )Turbulence in Arteries .Research seminar for the REACH program, University of Cincinnati , Cincinnati, OH.

C. K. Holland (04-05-1997. )Noninvasive Assessment of Turbulent Flow in Arteries .Ben Felson Lecture Presentations, Radiology Dept., University of Cincinnati , Cincinnati, OH.

C. K. Holland (03-30-1996. )Bioeffects in Rat Lung from Diagnostic Ultrasound .Ben Felson Lecture Presentations, Radiology Dept., University of Cincinnati , Cincinnati, OH.

C. K. Holland (02-13-1996. )Ultrasound Physics III .Trauma/Critical Care Division, Department of Surgery, University of Cincinnati , Cincinnati, OH.

C. K. Holland (01-30-1996. )Ultrasound Physics II .Trauma/Critical Care Division, Department of Surgery, University of Cincinnati , Cincinnati, OH.

C. K. Holland (01-16-1996. )Ultrasound Physics I .Trauma/Critical Care Division, Department of Surgery, University of Cincinnati , Cincinnati, OH.

C. K. Holland (1996. )Potential bioeffects of ultrasound in lungs and intestines .Medical Physics 23, 1069 ,

C. K. Holland (1996. )Biophysical bubble dynamics: Theory and prediction in bio-like fluids .The Conference for Ultrasonics in Biophysics and Bioengineering , Allerton Park, Monticello, Illinois, University of Illinois at Urbana-Champaign .

C. K. Holland (1995. )Bioeffects and the Thermal Index .AAPM Summer School, Connecticut College , New London, CT .

C. K. Holland (1995. )Bioeffects and the Mechanical Index .AAPM Summer School, Connecticut College , New London, CT .

C. K. Holland (04-11-1995. )Doppler and His Effect on Medical Imaging .Howard Hughes Medical Institute Special Lecture, Swarthmore College , Swarthmore, PA.

C. K. Holland (04-01-1995. )Lower Extremity Volumetric Blood Flow Measurement in Normal Subjects .Ben Felson Lecture Presentations, Radiology Dept., University of Cincinnati, Cincinnati, OH.

C. K. Holland (03-22-1995. )Direct Evidence of Cavitation In Vivo From Diagnostic Ultrasound .Medical Physics Seminar, Dept. of Radiology, University of Cincinnati , Cincinnati, OH.

C. K. Holland (10-20-1994. )Doppler Physics and Bioeffects .Dept. of Aerospace Engineering & Engineering Mechanics, Introduction to Biomechanics, 20-251-627 ,

C. K. Holland (10-18-1994. )Ultrasound Physics .Dept. of Aerospace Engineering & Engineering Mechanics, Introduction to Biomechanics, 20-251-627 ,

R. E. Apfel, C. K. Holland, L. A. Crum, and R. A. Roy (1992. )Acoustic cavitation from diagnostic ultrasound .J. Acoust. Soc. Am. 91, No. 4, Pt. 2, 2430 ,

C. K. Holland (1991. )In vitro cavitation: Bubble thresholds in water with a controlled nuclei environment .The Conference for Ultrasonics in Biophysics and Bioengineering, Allerton Park, University of Illinois at Urbana-Champaign , Monticello, Illinois.

C. K. Holland (1990. )A simple index for estimating the likelihood of transient cavitation from diagnostic ultrasound .Medical Physics 17, 556 ,

C. K. Holland (1990. )Gauging the likelihood of transient cavitation from clinical diagnostic ultrasound .International Symposium on the Mechanisms of Acoustical Bioeffects, Pushchino, USSR .

Paper Presentations

N. M. Ivancevich, K. J. Haworth, K. E. Hitchcock, C. K. Holland (2010. )Determination of optimal ultrasound parameters for ex vivo sonothombolysis .

V. A. Salgaonkar, C. K. Holland, T. D. Mast (2010. )Spatially sensitive passive cavitation detection with ultrasound imaging arrays during focused ultrasound ablation .

H. Kim, G. L. Britton, C. K. Holland, D. D. McPherson, S. L. Huang (09-30-2009. )Ultrasoundcontrolled therapeutic gas delivery provides enhanced neuroprotection following hypoxic ischemia .

C. K. Holland (09-30-2009. )Ultrasound enhanced thrombolysis .

C. K. Holland (09-30-2009. )Ultrasound mediated drug delivery .

Y.-J. Geng, M. Klegerman, C. Holland, D. McPherson (2009. )Targeted delivery of stem cells to atherosclerotic arteries using immunoliposomes .

A. Y. Ammi, S. Datta, S. R. Perrin, Jr., Sh. L. Beiler, C. R. Beiler, K. R. Wagner, C. K. Holland (2009. )120 kilohertz ultrasound-enhanced thrombolysis in a porcine intracerebral hemorrhage model .

K . E. Hitchcock, J. T. Sutton, D. N. Caudell, G. J. Pyne-Geithman, M. E. Klegerman, S. L. Huang, D. Vela, D. D. McPherson, C. K. Holland (2009. )Delivery of targeted echogenic liposomes in an ex vivo mouse aorta model .

J. A. Kopechek, T. M. Porter, C.-C. Coussios, S. R. Perrin, Jr., S.-L. Huang, D. D. McPherson, C. K. Holland (2009. )Acoustic characterizaiton of echogenic liposomes: Attenuation and quantitative backscatter .

G. J. Shaw, J. M. Meunier, C. K. Holland (2009. )Exogenous plasminogen increases tPA lytic efficacy in in-vitro human clot .

A. Y. Ammi, S. Beiler, K. E. Hitchcock, S. Vaidya, K. R. Wagner, T. D. Mast, G deCourten- Myers, C. K. Holland (2008. )120-kHz ultrasound-enhanced thrombolysis in a porcine intracerebral hemorrhage model .

J. M. Meunier, D. A. B. Smith, C. K. Holland, S.-L. Huang, D. D. McPherson, G. J. Shaw (2008. )120 kHz pulsed ultrasound enhanced thrombolysis with tPA-loaded echogenic liposomes .

C. K. Holland (2008. )Interactions between clot and ultrasound: Better blood clot break-up with bubbles .

A. Y. Ammi, T. D. Mast, I.-H. Huang, T. A. Abruzzo, C.-C. Coussios, G. J. Shaw, C. K. Holland (2008. )Characterization of ultrasound propagation through ex-vivo human temporal bone .

D. D. McPherson, S. Huang, C. K. Holland (2008. )Echogenic liposomes for molecular targeted therapeutic delivery .

S. Huang, D. D. McPherson, C K. Holland (2008. )Echogenic liposomes for vasoactive gas delivery and inhibition of intima hyperplasia in atheroproliferative disease .

C. K. Holland and D. D. McPherson (2008. )Echogenic liposomes for image-guided drug delivery .

C. K. Holland (2008. )Ultrasound contrast in sonothrombolysis .

G. J. Shaw, J. M. Meunier, C. J. Lindsell, C. K. Holland (2008. )Optimal tPA concentration for 120 kHz ultrasound enhanced thrombolysis .

J. M. Meunier, D. A. B. Smith, C. K. Holland, S. Huang, D. D. McPherson, G. J. Shaw (2007. )120 kHz pulsed ultrasound enhanced thrombolysis with tissue plasminogen activatorloaded echogenic liposomes .

S. Datta, A. Y. Ammi, C. C. Coussios, C. K. Holland (2007. )Monitoring and simulating stable cavitation during ultrasound-enhanced thrombolysis .

J. A. Kopechek, S. M. Chzanowski, D. A. B. Smith, W. B. Gaskins, T. A. Abruzzo, S-L Huang, D. D. McPherson, C. K. Holland (2007. )Ultrasound-mediated release of calcein from echogenic liposomes .

D. A. B. Smith, S. Vaidya, J. A. Kopechek, K. E. Hitchcock, S. L. Huang, D. D. McPherson, C. K. Holland (2007. )Echogenic liposomes loaded with recombinant tissue-type plasminogen activatory (rt-PA) for image-guided, ultrasound-triggered drug release .

T. Abruzzo, B. Wang, J. Kopechek, P. Kee, D. Smith, J. Collier, R. McDonald, D. McPherson, C. Holland (2007. )Ultrasound-Mediated Drug Release From Nanoscale Echogenic Liposomes .

G. J. Shaw, T. M. Porter, J. M. Meunier, D. Woo, C. K. Holland (2007. )Low-intensity 120-kHz pulsed ultrasound "busts more clot" than 2-MHz transcranial Doppler in the presence of rtPA .

C. K. Holland, S. Datta, S. S. Vaidya, J. M. Meunier, G. J. Shaw and C.-C. Coussios (2006. )Ultrasound-enhanced thrombolysis .

S. Datta, S. S. Vaidya, S. Beiler, G. de Courten-Meyer, C. K. Holland (2006. )Ultrasound-assisted penetration of rt-PA into clots to enhance thrombolysis .

T. M. Porter, C. K. Holland, J. M. Meunier, G. J. Shaw (2006. )Enhancement of recombinant tissue-plasminogen activator (rt-PA) with 2-MHz transcranial Doppler ultrasound .

V. M. Nahirnyak and C. K. Holland (2006. )Ultrasound hyperthermia in clotted blood and ex vivo cranial bone .

C. K. Holland (2006. )Ultrasound-enhanced drug delivery will achieve widespread clinical use .

T. D. Mast, V. A. Salgaonkar, C. Karunakaran, J. A. Besse, S. Datta, C. K. Holland (2006. )Measurements of cavitation dose, echogenicity, and temperature during ultrasound ablation .

C. K. Holland, T. M. Porter, D. D. McPherson (2006. )Ultrasound-assisted drug delivery and thrombolysis .

S. R. More, T. C. Lim, M. Li, C. K. Holland, S. E. Boyce, J-H. Lee (2006. )Structural-Acoustic Analysis, Identification and Control of a 4T MRI Scanner .

D. A. B. Smith, T. M. Porter, C. K. Holland, S.-L. Huang, R. C. MacDonald, D. D. McPherson (2006. )Destruction thresholds of echogenic liposomes with clinical diagnostic ultrasound .

T. M. Porter, S. S. Vaidya, C. K. Holland, S-L Huang, R. C. MacDonald, D. D. McPherson (2006. )Quantification of the pressure threshold for Optison® destruction .

G. J. Shaw, J. M. Meunier, J. Y. Cheng, C. K. Holland (2006. )Duty cycle dependence of 120-kHz pulsed ultrasound enhancement of thrombolysis in human clots .

J. M. Meunier, C. K. Holland, A. M. Pancioli, and G. J. Shaw (2006. )120-kHz ultrasound enhances rt-PA and Eptifibatide thrombolysis in human clots .

S. Tiukinhoy-Laing, S. Huang, D. S. Parikh, J Martinez, S. S. Vaidya, C. K. Holland, R. C. MacDonald, D. D. McPherson (2005. )Ultrasound-facilitated lot lysis using tPA-loaded echogenic liposomes .

G. J. Shaw, J. M. Meunier, J. Y. Cheng, C. K. Holland (2005. )Duty cycle dependence of ultrasound enhanced thrombolysis in an in-vitro human clot model .

V. M. Nahirnyak, S. W. Yoon, C. K. Holland (2005. )Acousto-mechanical and thermal properties of clotted blood .

T. M. Porter, S. S. Vaidya, C. K. Holland, S-L Huang, R. C. MacDonald, D. D. McPherson (2005. )Evaluation of backscattered intensity to quantify the destruction rate of echogenic liposomes .

D. A. B. Smith, T. M. Porter, C. K. Holland, S-L Huang, R. C. MacDonald, D. D. McPherson (2005. )Effect of clinical diagnostic ultrasound pressure amplitude and pulse repetition frequency on echogenic liposome destruction .

S. Datta, L. E. McAdory, J. Tan, C. K. Holland (2005. )Cavitation detection during ultrasoundassisted thrombolysis in porcine blood clots .

J. Y. Cheng, C. K. Holland, G. J. Shaw (2004. )Microscopic imaging study of recombinant tissue plasminogen activator thrombolysis with 120-KHz ultrasound in an in-vitro human clot model .

S. R. More, T. C. Lim, C. K. Holland, J-H. Lee (2004. )Characterization of the acoustic noise response of a 4T MRI scanner .

G. J. Shaw, A. Dhamija, C. K. Holland (2004. )Effect of temperature on ultrasound-enhanced thrombolysis .

M K. Tiede, S. E. Boyce, C. K. Holland and K. A. Choe (2004. )A new taxonomy of American English /r/ using MRI and ultrasound .

T. M. Porter, C. K. Holland, S. Datta (2004. )In vitro characterization of echogenic liposomes by acoustic scattering at 3.5 - 15.0 MHz .

J. Y. Cheng, C. K. Holland and G. J. Shaw (2004. )In vitro microscopic imaging of rt-PA thrombolysis with 120-KHz ultrasound in a human clot model .

C. K. Holland, C.-C. Coussios, L. Jakubowska, S. Huang, R. C. MacDonald, A. Nagaraj, D. D. McPherson (2003. )In vitro characterization of liposomes and optison by acoustic scattering at 3.5 MHz .

C.-C. Coussios, C. K. Holland, L. Jakubowska, S.-L. Huang, R. C. MacDonald, A. Nagaraj, and D. D. McPherson (2003. )Acoustic characterization of liposome suspensions and Optison® at 3.5 MHz .

G. J. Shaw, A. Dhamija, C. K. Holland and K. R. Wagner (2003. )Temperature dependence of tPA thrombolysis in an in-vitro clot model .Washington, D.C..

GJ Shaw, A Dhamija, CK Holland and KR Wagner (2003. )Temperature dependence of tPA thrombolysis in an in-vitro clot model .

C.-C. Coussios, C. K. Holland and G. J. Shaw (2002. )Transmission of a large unfocused 120-kHz and 1-MHz ultrasound beam through the human skull .

C. K. Holland, S. S. Vaidya, C.-C. Coussios, and G. J. Shaw (2002. )Thrombolytic effects of 120- kHz and 1-MHz ultrasound and tissue plasminogen activator on porcine whole blood clots .

G. J. Shaw, S. S. Vaidya, K. R. Wagner, and C. K. Holland (2002. )1-MHz Ultrasound Assists Clot Lysis .

C. K. Holland, R. A. Roy, P. W. Biddinger, C. J. Disimile, C. Cawood (2001. )Cavitation mediated rat lung bioeffects from diagnostic ultrasound .

G. J. Shaw, N. L. Hahn, K. R. Wagner, D. S. Kanter, C. K. Holland (2001. )Ultrasound assisted clot lysis for stroke therapy .

G. J. Shaw, N. L. Hahn, K. R. Wagner, D. S. Kanter, C. K. Holland (2001. )Ultrasound assisted thrombolysis in an in-vitro clot model .

J. Stanek, W. Kossenjans, C. K. Holland, L. Myatt, T. A. Siddiqi (2000. )Is the human hemochorial placenta impermeable to gas-carrier ultrasound contrast agents .

C. K. Holland, C. J. Disimile, P. A. Bejarano, C. Cawood, W. A. Karle (2000. )Threshold of rat lung damage from 6.0 MHz pulsed Doppler ultrasound .

C. K. Holland, J. T. Flament (1999. )The acoustic field of a clinical pulsed Doppler ultrasound system near lung .

M. M. Miller, C. K. Holland, P. J. Disimile (1999. )Assessing arterial stenoses by tracking turbulence with Doppler ultrasound .

J. S. Moulton, S. E. Braley, K. A. Choe, C. K. Holland (1999. )Significance of adrenal masses detected by CT: Relation to oncologic history .

C. K. Holland (1999. )Fundamentals of the Mechanical Index and caveats in its application .

C. K. Holland (1998. )Mechanical Mechanisms Update .

J. S. Stroud, C. K. Holland (1997. )Assessment of turbulent flow in arteries using Doppler ultrasound .

C. K. Holland, J. S. Stroud, N. E. Reinhart (1996. )Quantitative assessment of arterial stenoses using Doppler ultrasound and magnetic resonance imaging .Snowbird, Utah .

C. K. Holland (1996. )Bioeffects in rat lungs from diagnostic ultrasound .

S. Arora, C. K. Holland, H. Pedersen, K. J. W. Taylor, R. J. Gusberg, G. H. Meier (1995. )Noninvasive impedance estimation in an in vitro pulsatile flow model .

C. K. Holland, X. Zheng, R. E. Apfel, J. L. Alderman, L. Fernandez, K. J. W. Taylor (1995. )Direct evidence of cavitation in vivo from diagnostic ultrasound .

C. K. Holland, J. M Brown, L. M. Scoutt, K. J. W. Taylor (1995. )Lower extremity volumetric blood flow measurement with Doppler ultrasound in normal subjects .

C. K. Holland, K. Sandstrom, X. Zheng, J. Rodriguey, R. A. Roy (1994. )The acoustic field of a pulsed Doppler diagnostic ultrasound system near a pressure-release surface .

Q. Xu, C. K. Holland, and R. E. Apfel (1992. )Measurement of cavitation thresholds for human blood .

J. S. Pellerito, C. K. Holland, S. K. Holland, R. I. White, L. W. Hammers, J. Barton, and K. J. W. Taylor (1992. )In vivo and in vitro observation of color persistence: A sign of peripheral arterial stenosis .

C. K. Holland, S. K. Holland, R. R. Bailey, J. S. Pellerito, J. C. Gatenby, and K. J. W. Taylor (1991. )Flow patterns in a stenosed artery model: In vitro experiments .

J. S. Pellerito, C. K. Holland, S. K. Holland, L. W. Hammers, R. I. White, J. Barton, and K. J. W. Taylor (1991. )Color persistence: an indicator of hemodynamically significant peripheral arterial stenosis .

L. W. Hammers, C. L. Quedens-Case, C. Y. Reinhold, C. K. Holland, and K. J. W. Taylor (1991. )Pulse Doppler ultrasound of focal liver masses .

R. E. Apfel and C. K. Holland (1991. )New approaches to the use of acoustic radiation forces in the calibration of high frequency transducers .

Q. Xu, C. K. Holland, and R. E. Apfel (1991. )Signal processing to extract transient microcavitation signals from noise .

R. A. Roy, C. K. Holland, R. E. Apfel, and L. A. Crum (1990. )Cavitation from diagnostic ultrasound .

C. K. Holland and R. E. Apfel (1989. )Effects of nuclei and host fluid parameters on the threshold for cavitation produced by pulsed ultrasound .

Honors and Awards

2008 -2009 Richard Akeson Excellence in Teaching Award College of Medicine, University of Cincinnati

2008 Master Educator Award College of Engineering, University of Cincinnati

2007 Distinguished Researcher Award College of Engineering, University of Cincinnati

2006 -To Present Editor-in-Chief Ultrasound in Medicine and Biology

2003 -2006 Associate Editor Ultrasound in Medicine and Biology

06-2003 Attended The Whitaker Foundation Academic Leadership Program

2001 Fellow Acoustical Society of America

2000 Fellow American Institute of Ultrasound in Medicine

2000 American Institute of Ultrasound in Medicine Presidential Recognition Award

1990 International Union for Pure and Applied Biophysics Young Scientist Award Pushchino, USSR

1983 Emanuel Gratenstein Fellowship Yale University

1983 Sigma Xi

1983 Graduated Cum Laude Wellesley College

2013 Joseph H. Holmes Basic Science Pioneer Award, American Institute of Ultrasound in Medicine

2010 Student Council Mentoring Award, Acoustical Society of America

Student Advising

Jason Raymond (Master )Advisor

Matthew Gruber Advisor

Jonathan Sutton Advisor

Stephen Perrin (Undergrad )Advisor

Kirthi Radhakrishnan Advisor

Jonathan Kopechek Advisor

Kate Hitchcock (Doctoral )Advisor

Saurabh Datta (Doctoral )Advisor

Denise Smith (Doctoral )Advisor

Jun Tan (Undergrad )Advisor

Volodya Nahirnyak (Doctoral )Advisor

Nancy Hahn Advisor

Kim Philippi (Master )Advisor

Donnevan Blake (Master )Advisor

Megan Miller (Master )Advisor

Patrick Whitlock (Doctoral )Advisor

Jeff Vaitekunas (Doctoral )Advisor

Ilya Alexeev (Doctoral )Advisor

Service

(Intellectual Property Committee )Committee Chair Type:University/College Service 2009 -2011

(Information Technology Infrastructure Committee )Committee Member Type:University/College Service 2005 -2008

College of Engineering (Decanal Review Committee )Committee Member Type:University/College Service 2003

College of Medicine (Committee on Committees )Committee Member Type:University/College Service 2010 -To Present

College of Medicine (Faculty Forum Executive Committee )Committee Member Type:University/College Service 2000 -To Present

University Hospital (Ultrasound Credentialing Subcommittee Chair )Committee Chair Type:University/College Service 2002

(UCBME Head Search Committee )Committee Member Type:University/College Service 2002

Rowe Center for Women Engineers (Steering Committee )Committee Member Type:University/College Service 2001 -2002

College of Medicine (Women Faculty Advisory Committee )Committee Member Type:University/College Service 1997 -1998

College of Medicine (Committee on Research )Co-Chair Type:University/College Service 1995 -1997

Facilitation of Research subcommittee (Core Facilities subcommittee )Committee Member Type:University/College Service 2007 -2009

(Director of Graduate Studies )Director Type:Departmental Service 2007 -2009

(Promotion and Tenure Committee )Committee Chair Type:Departmental Service 2006 -To Present

Medical Imaging Faculty (UCBME Faculty Search Committee )Committee Chair 2004

Center for Imaging Research (UCBME Faculty Search Committee )Committee Chair Type:Departmental Service 2002

Department of Biomedical Engineering (Research Administration )Director Type:Departmental Service 2001 -2007

(Women in Discovery Executive Committee )Committee Member Type:Departmental Service 2001

Department of Radiology (Committee on Research )Committee Chair Type:Departmental Service 1996 -2001

(Scientific Advisory Committee )Committee Chair Type:Departmental Service 1995 -2001

Positions and Work Experience

2010 -To Present Professor, Internal Medicine, Division of Cardiovascular Diseases, Biomedical Engineering Program, and Radiology ,

2009 -2010 Professor, Depts. Of Biomedical Engineering and Radiology, University of Cincinnati, Colleges of Engineering and Medicine

2001 -2009 Associate Professor, Director of Graduate Studies (2008-2009) Tenured 09/2005 Director of Research (2001-2007) , University of Cincinnati, Colleges of Engineering and Medicine

1999 -2001 Adjunct Associate Professor, University of Cincinnati, Dept. of Aerospace Engineering and Engineering Mechanics

1994 -2001 Research Associate Professor, (Medical Physics), University of Cincinnati, College of Medicine

1994 -2001 Acoustics Consultant, Trustees for the Bowling/Pfizer Heart Valve 1994, 2001 Settlement Fund, federal court appointed scientific advisory committee ,

1991 -1994 Associate Research Scientist, (Ultrasound Physics), Yale School of Medicine, Dept. of Diagnostic Radiology

1989 -1991 Post-Doctoral Associate, Joint appointment with Dept. of Diagnostic 1989-91 Radiology , Yale School of Medicine and Dept. of Mechanical, Radiology

1985 -1986 Architectural Acoustics Consultant, Cesar Pelli & Associates 1985-86 (Modified Ley Student Center at Rice Univ., Houston, Texas) (Thresholds of cavitation produced by pulsed ultrasound), Yale University, Department of Mechanical Engineering

2009 -To Present Professor, (Introduction to Biomedical Engineering; Medical Imaging), University of Cincinnati, Biomedical Engineering and Radiology

2001 -2009 Associate Professor, (Introduction to Biomedical Engineering; Medical Imaging), University of Cincinnati, Dept. of Biomedical Engineering

1994 -2001 Research Associate Professor, (Ultrasound Physics; Radiologic Instrumentation and Engineering), University of Cincinnati, Dept. of Radiology

1991 -1994 Associate Research Scientist, (Ultrasound Physics for Radiology Residents), Yale University , Dept. of Diagnostic Radiology

1989 -1991 Postdoctoral Associate, (Ultrasound Physics for Sonographers), Yale University, Depts. of Mechanical Engineering and Diagnostic Radiology

1987 - Visiting Lecturer, (Architectural Acoustics), Yale University, School of Architecture

1985 -1987 Teaching Fellow, (Computer Laboratory, and Physics of Musical Instruments), Yale University, Dept. of Applied Physics

1983 - Instructor, "Wintersession", (Music Appreciation), Wellesley College ,

1982 -1983 Teaching Assistant, (Music Theory), Wellesley College , Dept. of Music

Post Graduate Training and Education

Junior Year Abroad, (studied Beethoven and Schubert), Universitaet Freiburg and Hochschule fuer Musik Freiburg , ,Freiburg im Breisgau, Deutschland

1990-1991 Postdoctoral Fellow, Diagnostic Radiology, Yale University, ,New Haven, CT

Keywords

Mechanical Bioeffects of Diagn,Medical Ultrasound,Doppler ultrasound,Acoustic Cavitation,Stroke Therapy Echo Contrast Agents Targeted Liposomes Acoustic Cavitation Biomedical Ultrasound,Analytical, Diagnostic and Therapeutic Techniques and Equipment(MeSH E),Cardiovascular Diseases(MeSH C14),Diagnosis(MeSH E01),Therapeutics(MeSH E02),Investigative Techniques(MeSH E05),Equipment and Supplies(MeSH E07)

Research and Practice Interests

  • Bioeffects of Diagnostic and Therapeutic Ultrasound
  • Acoustic Cavitation
  • New Diagnostic imaging Techniques for the Early Detection of Vascular Disease and Ischemic Injury to Brain

Professional Affiliation

Acoustical Society of America, Fellow: Elected to Executive Council (1999-2002) Cavitation Working Group (Technical Report S1/WG22), published in 2000 Physical Acoustics Technical Committee (1997 - 2006) Biomedical Ultrasound Technical Committee (1996 - ) Membership Committee (2008 - 2011) Nominating Committee (1996) Ethics Committee (1996) Committee on Public Relations (1994 - 2010)

American Institute of Ultrasound in Medicine, Fellow: American Institute of Ultrasound in Medicine, Fellow: Elected as Officer, Secretary (2001 - 2005) Elected to Board of Governors (1998 - 2001) Co-Chair, Mechanical Bioeffects Conference (Aspen, CO: August 1998) Organizing Committee, Bioeffects Conference (Keystone, CO: August 2005) Organizing Committee, Workshop on Effects of Non-linear Propagation on Output Display Indices (TI and MI), (1998) Bioeffects Committee (1994-1997)

Courses Taught

20-BME-611 IMGNG W/O INZNG RAD

20-BME-702 BME SEMINAR WIN

20-BME-601 BME SURVEY

Patents and Inventions

US9675820B2 Ultrasound-mediated inducement, detection and enhancement of stable cavitation C. K. Holland, S. Datta, T. D. Mast, N. Ivancevich, K. E. Hitchcock, K. Haworth, Awarded 06-13-2017 Inventor https://patents.google.com/patent/US9675820B2/en

US9814672B2 Echogenic vehicle for clinical delivery of plasminogen activator and other fribrin-binding therapeutics to thrombi S. T. Laing, S. Huang, D. D. McPherson, C. K. Holland, M. E. Klegerman, 11-14-2017 Co-Inventor https://patents.google.com/patent/US9814672B2/en?q=rt-PA&q=loaded&q=echogenic&q=liposomes

7,300,414 Transcranial ultrasound thrombolysis system and method of treating a stroke C. K. Holland, D. S. Kanter, L. J. Busse, K. R. Wagner, Awarded 11-27-2007 https://patents.google.com/patent/US7300414B1/en

US20160250252A1 Bioactive Gas-Encapsulated Echogenic Liposomes and Methods for Treating Cardiovascular Disease C. K. Holland, Jason L. Raymond, Jonathan T. Sutton, Filed Inventor https://patents.google.com/patent/US20160250252A1/en

PCT/US2016/048934 WO2017035454A1 Scavenging Dissolved Oxygen via Acoustic Droplet Vaporization K. Radhakrishnan, C. K. Holland, K. J. Haworth, Filed Co-Inventor https://patents.google.com/patent/WO2017035454A1/en

PCT/US2016/048934 Dissolved Oxygen Scavenging by Acoustic Droplet Vaporization Using Intravascular Ultrasound K. J. Haworth, C. K. Holland, K. Mercado-Shekhar, A. Redington, B. Goldstein, Co-Inventor

US9669203B2 Methods of enhancing delivery of drugs using ultrasonic waves and systems for performing the same C. K. Holland, K. E. Hitchcock, K. Haworth, N. Ivancevich, T. D. Mast, Awarded 06-06-2017 Inventor https://patents.google.com/patent/US9669203B2/en

14/957,705 Gas-encapsulated acoustically responsive stabilized microbubbles and methods for treating cardiovascular disease C. K. Holland, H. Shekhar, A. Palaniappan, Inventor

U.S. Patent Application 14/957,705 Gas-encapsulated acoustically responsive stabilized microbubbles and methods for treating cardiovascular disease C. K. Holland, H. Shekhar, A. Palaniappan, Filed Inventor Gas-encapsulated acoustically responsive stabilized microbubbles and methods for treating cardiovascular disease

Contact Information

Academic - Cardiovascular Center
231 Albert Sabin Way
Cincinnati  Ohio, 45267-0586
Phone: 513-558-5675
Fax: 513-558-6102
christy.holland@uc.edu