Christian Hong

Christian Hong , PhD

Associate Professor

Medical Sciences Building
Room 4201
231 Albert Sabin Way
Cincinnati, Ohio 45267-0576
Phone 513-558-5093
Fax 513-558-5738
Email christian.hong@uc.edu

Professional Summary

Dr. Hong studied mathematical modeling of circadian rhythms as a graduate student, and learned how to apply genetic and molecular biological approaches to problems of cellular regulation, using Neurospora crassa, a tractable experimental system for circadian biology. As a young investigator who has crossed disciplines from mathematical biology to genetics and molecular biology, Dr. Hong believes that such interdisciplinary approaches will lead to the innovative therapies of the future. He joined the Department of Molecular & Cellular Physiology in April, 2010. 

Education

PhD: Virginia Tech 2003 (Mathematical Modeling)

BS: Virginia Tech 1997 (Biology)

MS: Virginia Tech 1999 (Mathematical Modeling)

Research and Practice Interests

Research Support

Investigators:Hong, C I 01-2011 -12-2013 Damon Runyon Cancer Research Foundation Functional Roles of Circadian Rhythms in Cell Cycle and DNA Damage Controls Role:PI 450,000.00 Pending Type:Grant Level:National

Investigators:Hong, C I 06-2011 -05-2014 Searle Scholars Program Study of Functional Roles of Circadian Rhythms in Cell Cycle Progression Role:PI 300,000.00 Planned/In Preparation Type:Grant

Grant: #D12AP00005 Investigators:Ahn, Chong; Hong, Christian; Lim, Sookkyung; Song, Seongho 01-01-2012 -12-31-2015 Defense Advanced Research Projects Agency Uncovering General Principles of Network Dynamics of Circadian Rhythms, Cell Cycle, DNA Damage Response and Metabolism as Interconnected Modules. Role:PI $1,810,960.00 Active Level:Federal

Grant: #U19 AI116491 Investigators:Hong, Christian; Moore, Sean; Weiss, Alison; Wells, James; Zavros, Yana 03-01-2015 -02-29-2020 National Institute of Allergy and Infectious Diseases Organoids as a Model System for Studying Gastrointestinal Disease Role:Collaborator $931,304.00 Awarded Level:Federal

Grant: #1R21CA227379 Investigators:Hong, Christian; Zhang, Tongli 07-01-2018 -06-30-2020 National Cancer Institute (PQ6) Roles of circadian rhythms in tumor development Role:PI $208,800.00 Awarded Level:Federal

Grant: #R01DK117005 Investigators:Hong, Christian 09-15-2018 -05-31-2023 National Inst of Diabetes and Digestive and Kidney Disease Roles of circadian rhythms in gastrointestinal systems Role:PI $379,997.00 Active Level:Federal

Investigators:Hong, Christian 04-14-2021 -10-13-2021 Procter & Gamble Company Assessment of circadian phase shifts in Caco2 cells and HIEs by materials of interest Role:PI 61639.92 Active Level:Industry

Grant: #S10OD030402 Investigators:Closson, Chet; Fan, Guochang; Hong, Christian; Luo, Yu; Sadayappan, Sakthivel; Wang, Hongsheng; Weiss, Alison; Zhang, Yuhang 09-01-2021 -08-31-2022 Office of the Director, National Institutes of Health Leica Stellaris 8 Confocal Microscope Role:PI 598148.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Hong, Christian I; Zámborszky, Judit; Baek, Mokryun; Labiscsak, Laszlo; Ju, Kyungsu; Lee, Hyeyeong; Larrondo, Luis F; Goity, Alejandra; Chong, Hin Siong; Belden, William J; Csikász-Nagy, Attila (2014. ) Circadian rhythms synchronize mitosis in Neurospora crassa.Proceedings of the National Academy of Sciences of the United States of America, , 111 (4 ) ,1397-402 More Information

Lee, Kang Kug; Ahn, Chong H; Hong, Christian I (2013. ) Circadian rhythms in Neurospora crassa on a polydimethylsiloxane microfluidic device for real-time gas perturbations.Biomicrofluidics, , 7 (4 ) ,44129 More Information

Hong, Christian I; Zámborszky, Judit; Csikász-Nagy, Attila (2009. ) Minimum criteria for DNA damage-induced phase advances in circadian rhythms.PLoS computational biology, , 5 (5 ) ,e1000384 More Information

Hong, Christian I; Jolma, Ingunn W; Loros, Jennifer J; Dunlap, Jay C; Ruoff, Peter (2008. ) Simulating dark expressions and interactions of frq and wc-1 in the Neurospora circadian clock.Biophysical journal, , 94 (4 ) ,1221-32 More Information

Zámborszky, Judit; Hong, Christian I; Csikász Nagy, Attila (2007. ) Computational analysis of mammalian cell division gated by a circadian clock: quantized cell cycles and cell size control.Journal of biological rhythms, , 22 (6 ) ,542-53 More Information

Hong, Christian I; Conrad, Emery D; Tyson, John J (2007. ) A proposal for robust temperature compensation of circadian rhythms.Proceedings of the National Academy of Sciences of the United States of America, , 104 (4 ) ,1195-200 More Information

Dunlap, J C; Loros, J J; Colot, H V; Mehra, A; Belden, W J; Shi, M; Hong, C I; Larrondo, L F; Baker, C L; Chen, C-H; Schwerdtfeger, C; Collopy, P D; Gamsby, J J; Lambreghts, R (2007. ) A circadian clock in Neurospora: how genes and proteins cooperate to produce a sustained, entrainable, and compensated biological oscillator with a period of about a day.Cold Spring Harbor symposia on quantitative biology, , 72 ,57-68 More Information

Loros, J J; Dunlap, J C; Larrondo, L F; Shi, M; Belden, W J; Gooch, V D; Chen, C-H; Baker, C L; Mehra, A; Colot, H V; Schwerdtfeger, C; Lambreghts, R; Collopy, P D; Gamsby, J J; Hong, C I (2007. ) Circadian output, input, and intracellular oscillators: insights into the circadian systems of single cells.Cold Spring Harbor symposia on quantitative biology, , 72 ,201-14 More Information

Mehra, Arun; Hong, Christian I; Shi, Mi; Loros, Jennifer J; Dunlap, Jay C; Ruoff, Peter (2006. ) Circadian rhythmicity by autocatalysis.PLoS computational biology, , 2 (7 ) ,e96 More Information

Tyson, J J; Hong, C I; Thron, C D; Novak, B (1999. ) A simple model of circadian rhythms based on dimerization and proteolysis of PER and TIM.Biophysical journal, , 77 (5 ) ,2411-7 More Information

Dovzhenok, Andrey A; Baek, Mokryun; Lim, Sookkyung; Hong, Christian I (2015. ) Mathematical modeling and validation of glucose compensation of the neurospora circadian clock.Biophysical journal, , 108 (7 ) ,1830-9 More Information

Zámborszky, Judit; Csikász-Nagy, Attila; Hong, Christian I (2014. ) Neurospora crassa as a model organism to explore the interconnected network of the cell cycle and the circadian clock.Fungal genetics and biology : FG & B, , 71 ,52-7 More Information

Moore, Sean R; Pruszka, Jill; Vallance, Jefferson; Aihara, Eitaro; Matsuura, Toru; Montrose, Marshall H; Shroyer, Noah F; Hong, Christian I (2014. ) Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine.Disease models & mechanisms, , 7 (9 ) ,1123-30 More Information

Chen, Shuang; Brunskill, Eric W; Potter, S Steven; Dexheimer, Phillip J; Salomonis, Nathan; Aronow, Bruce J; Hong, Christian I; Zhang, Tongli; Kopan, Raphael (2015. ) Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan.Developmental cell, , 35 (1 ) ,49-62 More Information

Caicedo-Casso, Angélica; Kang, Hye-Won; Lim, Sookkyung; Hong, Christian I (2015. ) Robustness and period sensitivity analysis of minimal models for biochemical oscillators.Scientific reports, , 5 ,13161 More Information

Cockrell, Allison L; Pirlo, Russell K; Babson, David M; Cusick, Kathleen D; Soto, Carissa M; Petersen, Emily R; Davis, Miah J; Hong, Christian I; Lee, Kwangwon; Fitzgerald, Lisa A; Biffinger, Justin C (2015. ) Suppressing the Neurospora crassa circadian clock while maintaining light responsiveness in continuous stirred tank reactors.Scientific reports, , 5 ,10691 More Information

Encyclopedia Article

Hong, C I (2010. ) Encyclopedia of Systems Biology .Springer (Author)

Presentations

Invited Presentations

(06-2008. ) Harvard Medica School, Boston, MA.

(04-2008. ) The Microsoft Research - University of Trento, Center for Computational and Systems Biology, Trento, IT.

(03-2008. ) Computational Cell Biology, Cold Spring Harbor & Wellcome Trust, Hinxton, UK.

(05-2007. ) Postdoctoral seminar series at Dartmouth Medical School, Hanover, NH.

(01-2005. ) Young Generation Technical Leadership Conference, San Francisco, CA.

(06-2004. ) Society for Research on Biological Rhythms Conference, Whistler, BC.

(03-2003. ) The Kavli Institute for Theoretical Physics on Biological Networks Workshop at UCSB, Santa Barbara, CA.

(05-2002. ) Society,

(05-2002. ) Society for Research on Biological Rhythms Conference, Amelia Island, FL.

(03-1999. ) Molecular Cell Biology and Bitechnology Seminar, Blacksburg, VA.

Poster Presentations

Hong, C I (05-2010. ) (In Press. ) Mechanistic Analysis of Frequency Demultiplication .The Society for Research on Biological Rhythms, San Destin, FL, USA. . Conference. . Level:International

Honors and Awards

-06-2008 The 2008 Kronauer Award in Excellence in Biomathematical Modeling Status:Recipient

-03-2008 Computation Cell Biology, Cold Spring Harbor & Wellcome Trust Travel Award; Hinxton, UK Status:Recipient

07-2007 -08-2007 Kavli Institute for Theoretical Physics workshop on Biologica Switches and Clocks Invited Fellow Status:Recipient Type:Fellowship

05-2004 -04-2006 National Academies Keck Futures Initiative Signaling Grant Status:Recipient Type:Grant

08-2005 -10-2005 The University of Stavanger, Norway, Norwegian Research Council: Leiv Eirikson mobility grant Visiting Fellow Status:Recipient Type:Grant

-07-2005 The European Conference on Mathematical and Theoretical Biology, Dresden, Germany Travel Award Status:Recipient

02-2003 -07-2003 The Collegium Budapest, Institute for Advanced Study in Budapest Hungary Junior Fellow Status:Recipient Type:Fellowship

06-2000 Gordon Research Conference in Theoretical Biology, Tilton, NH Travel Award Status:Recipient

Professional Affiliation

06-2000 -To Present: Society for Mathematical Biology Member

09-2002 -To Present: Korean-American Scientists and Engineers Association Member

05-2010: Member The Society for Research on Biological Rhythms

Contact Information

Academic - Medical Sciences Building
Room 4201
Cincinnati  Ohio, 45267-0576
Phone: 513-558-5093
Fax: 513-558-5738
christian.hong@uc.edu