Professional Summary
Dr. Ho received her PhD at the University of Hong Kong. She was recruited to the biology department of Tufts University as a tenure-track assistant professor in 1980, becoming a full professor in 1995; in 1997 she was appointed associate dean for research. In 1999, she joined the faculty of the University of Massachusetts Medical School where she held numerous leadership positions, including vice chair of research, director of urologic research and director of translational research in the department of surgery, and co-director of the genitourinary oncology program at the UMass Cancer Center, before being recruited to UC to head the Department of Environmental Health in October 2005.
Internationally recognized for her expertise in endocrine disruption and hormonal carcinogenesis of the prostate, breast, ovaries and endometrium; Dr. Ho’s research extends to the developmental basis of disease susceptibility by applying epigenetics to epidemiological studies, addressing two important challenges of research in environmental exposure and human health - multiple exposures at various developmental stages and the trans-generational effects of exposure. Her findings on EDC exposure, including Bisphenol A, helped raise concerns on in utero exposure to EDC in food and drinking water.
Her latest research focuses on estrogen signaling in prostate cancer, where her team recently discovered a new tumor-suppressive non-genomic estrogen signaling that can be exploited as a novel therapeutic option for advanced prostate cancer patients. Understanding this pathway may also help alleviate drug resistance associated with traditional hormone therapy.
Dr. Ho is an active participant in the Endocrine Society, the Society of Toxicology, the American Association for Cancer Research, Prostate Cancer Research Program, the American Urologic Society and the Society for Basic Urologic Research (past president). She regularly chairs scientific reviews and policy committees for the National Institutes of Health and the Department of Defense. She is a member of the Integration Panel of the Department of Defense Congressionally Directed Prostate Cancer Research Program, and has served on the National Academy of Sciences Standing Committee on Use of Emerging Science for Environmental Health Decisions. In 2007, she was honored by the Ohio Senate 127th General Assembly and was only the second woman to receive the Women in Urology Award from the SBUR and the Society of Women in Urology. The Prostate Cancer Foundation awarded her the Mentor of Excellence Award in 2013, and in August 2014, she was profiled in Endocrine-Related Cancer as a nationally and internationally recognized leader in the field. During 2015, the University of Cincinnati recognized her contribution by nominating and awarding her the George Rieveschl Award for Distinguished Scientific Research, and the Lifetime Achievement in Research.
Education
Bachelor's Degree: University of Hong Kong (Biological Sciences)
Doctoral Degree: University of Hong Kong (Zoology)
Research Support
Grant: #R01 CA112532 Investigators:Ho, Shuk Mei 07-01-2006 -05-31-2012 National Cancer Institute Hormone-Induced Inflammation and Prostate Cancer Role:PI $1,066,149.00 Closed Level:Federal
Grant: #R01 CA112570 Investigators:Ho, Shuk Mei 09-30-2005 -05-31-2011 National Cancer Institute Progesterone-mediated protection against ovarian cancer Role:PI $1,315,401.00 Active Level:Federal
Grant: #R21 ES013071 Investigators:Ho, Shuk Mei 09-30-2005 -06-30-2008 National Institute of Environmental Health Sciences Developmental Modulation of Mouse Uterine Tumorigenesis Role:PI $338,281.78 Closed Level:Federal
Grant: #R01 CA15776 Investigators:Ho, Shuk Mei 09-30-2005 -05-31-2010 National Cancer Institute Prostatic Differentiation and Sex Hormone Metabolism Role:PI $1,298,316.10 Closed Level:Federal
Grant: #R01 CA062269 Investigators:Ho, Shuk Mei 05-26-2006 -08-31-2009 National Cancer Institute Metallothionein and Cadmium Carcinogenesis in the Prostate Role:PI $724,034.69 Closed Level:Federal
Grant: #P30 ES06096 Investigators:Ho, Shuk Mei 04-01-2002 -03-31-2008 National Institute of Environmental Health Sciences Environmental Genetics Role:PI $7,207,664.00 Closed Level:Federal
Investigators:Ho, Shuk Mei 09-30-2005 -06-30-2007 National Cancer Institute CYP1A1, Estrogen Metabolism and Ovarian Carcinogenesis Role:PI $17,193.00 Closed Level:Federal
Grant: #R21 ES012281 Investigators:Ho, Shuk Mei 03-01-2006 -02-28-2007 National Institute of Environmental Health Sciences Estrogen Imprinting of the Prostate Gland Via Methylation Role:PI $44,122.00 Closed Level:Federal
Grant: #W81XWH-04-01-0165 Investigators:Ho, Shuk Mei 03-15-2006 -02-04-2008 Department of the Army Medical Research and Materiel Command Estrogen Receptor-Beta Hypermethylation and Prostate Carcinogenesis Role:PI $309,343.50 Closed Level:Federal
Grant: #P50 ES015905 / 5-75741 Investigators:Ho, Shuk Mei 09-29-2007 -05-31-2013 National Institute of Environmental Health Sciences The Role of Airborne PAHs and DEP in the Pathogenesis of Childhood Asthma Role:PI $1,106,887.00 Active Level:Federal
Grant: #SRS 005441 Investigators:Ho, Shuk Mei; Leung, Yuet Kin 01-01-2008 -06-30-2009 Ausio Pharmaceuticals LLC Ausio Pharmaceuticals-Contract Role:PI $40,000.00 Closed Level:Industry
Grant: #2007-04409 / R01-ES015584 Investigators:Ho, Shuk Mei 01-15-2008 -11-30-2012 National Institute of Environmental Health Sciences Epigenetic Basis for Prostate Carcinogenesis Following Early Estrogenic Exposures Role:PI $1,156,261.00 Closed Level:Federal
Grant: #P30 ES006096-16A1 Investigators:Caruso, Joseph; Deka, Ranjan; Embi, Peter; Greis, Kenneth; Ho, Shuk Mei; Lemasters, Grace; Medvedovic, Mario; Meller, Jaroslaw; Nebert, Daniel; Pinney, Susan; Puga, Alvaro; Rohs, Amy; Woo, Daniel 04-01-2008 -03-31-2013 National Institute of Environmental Health Sciences Environmental Genetics Role:PI $8,028,782.00 Active Level:Federal
Grant: #W81XWH-08-1-0443 Investigators:Ho, Shuk Mei; Waltz, Susan; Wang, Shao-Chun 09-02-2008 -09-01-2012 Department of the Army Medical Research Acquisition Activity Regulation of PCNA Function by Tyrosine Phosphorylation in Prostate Cancer Role:Collaborator $350,369.00 Active Level:Federal
Grant: #K99 ES016817 Investigators:Belcher, Scott; Ben-Jonathan, Nira; Ho, Shuk Mei; Levin, Linda; Revelo-Penafiel, Monica; Tam, Neville Ngai Chung; Tang, Wan Yee 09-02-2008 -08-31-2010 National Institute of Environmental Health Sciences Estrogens/Xenoestrogens and Epigenetic Regulation of Gene Expression Role:Collaborator $180,000.00 Closed Level:Federal
Grant: #R13 DK083204 Investigators:Ho, Shuk Mei 09-15-2008 -08-31-2009 National Inst of Diabetes and Digestive and Kidney Disease The 18th Annual Meeting of the SBUR: Epigenetics and Genitourinary Disorders Role:PI $12,000.00 Closed Level:Federal
Grant: #R01 CA125379 Investigators:Collins, Margaret; Ho, Shuk Mei; Knudsen, Karen; Lentsch, Alex; Waltz, Susan 09-01-2008 -07-31-2014 National Cancer Institute The Ron Receptor/Chemokine Axis in Prostate Cancer Role:Collaborator $1,275,379.00 Active Level:Federal
Grant: #31-3100050453 Investigators:Ho, Shuk Mei 09-01-2006 -06-30-2008 National Institute of Environmental Health Sciences Chris Curran and Eric Kendig-CHMC Training Grant Role:PI $43,086.00 Closed Level:Federal
Grant: #EB003730 Investigators:Guo, Peixuan; Ho, Shuk Mei 07-01-2009 -01-15-2012 National Institute of Biomedical Imaging and Bioengineering Assembly of Phi29 pRNA Nanoparticles for siRNA Delivery to Prostate Cancer Cells Role:Collaborator $756,907.00 Closed Level:Federal
Grant: #R01 EY015227 Investigators:Ho, Shuk Mei; Kao, Winston Whei Yang; Puga, Alvaro; Tam, Neville Ngai Chung; Xia, Ying 06-01-2009 -05-31-2014 National Eye Institute The Role of MAP 3 Kinase 1 in Ocular Surface Morphogenesis Role:Collaborator $1,759,938.00 Active Level:Federal
Grant: #F31 EY019458 Investigators:Geh, Esmond; Ho, Shuk Mei; Xia, Ying 03-01-2010 -02-28-2011 National Eye Institute Molecular Regulation of MAP3 Kinase1 in Ocular Morphogenesis Role:Collaborator $41,176.00 Closed Level:Federal
Grant: #CU / 3 P50 ES015905-03S1 Investigators:Ho, Shuk Mei 09-01-2009 -08-31-2011 National Institute of Environmental Health Sciences The Role of Airborne PAHS and DEP in the Pathogenesis of Childhood Asthma Role:PI $58,000.00 Closed Level:Federal
Grant: #28751 / 98013852 / RC2 ES018789 Investigators:Ho, Shuk Mei; Medvedovic, Mario 09-24-2009 -08-31-2011 National Institute of Environmental Health Sciences Developmental Reprogramming of Prostate Carcinogenesis by BPA Role:PI $729,951.00 Closed Level:Federal
Grant: #E4753 / RC2ES018758 Investigators:Ho, Shuk Mei; Medvedovic, Mario 09-21-2009 -06-30-2011 National Institute of Environmental Health Sciences Developmental Exposure to Low-Dose Bisphenol A and Human Prostate Cancer Role:PI $466,390.00 Closed Level:Federal
Grant: #E4779 / R01ES015584-02S1 Investigators:Ho, Shuk Mei; Lam, Ying Wai 09-04-2009 -08-31-2011 National Institute of Environmental Health Sciences Epigenetic Basis for Prostate Carcinogenesis following Early Estrogenic Exposures Role:PI $298,300.00 Closed Level:Federal
Grant: #W81XWH-09-1-0012 Investigators:Ho, Shuk Mei; Summe, Monica; Szeto, Ying Ying 01-15-2009 -02-14-2012 Department of the Army Medical Research Acquisition Activity Exposure to Maternal Diabetes in Utero and Transgenerational Breast Cancer Risk Role:Collaborator $96,718.00 Closed Level:Federal
Grant: #1 C06 RR028634-01 Rev Investigators:Ho, Shuk Mei 01-07-2010 -12-31-2014 National Center for Research Resources Kettering Lab Renovation to Enhance PHS-Supported Environmental Health Research Role:PI $4,819,500.00 Active Level:Federal
Grant: #K07 CA138714 Investigators:Bracken, R. Bruce; Ho, Shuk Mei; Lemasters, Grace; Rao, Marepalli; Succop, Paul; Wu, Tianying 09-08-2010 -08-31-2015 National Cancer Institute Global and Specific Oxidation Pathways Related to Prostate Cancer, Prospective and Cross-Sectional Analyses Role:Collaborator $656,117.00 Active Level:Federal
Grant: #U01 ES019480 Investigators:Belcher, Scott; Ben-Jonathan, Nira; Ho, Shuk Mei; Levin, Linda; Medvedovic, Mario; Miller, Marian; Stambrook, Peter; Tso, Patrick P.W. 09-22-2010 -05-31-2015 National Institute of Environmental Health Sciences Susceptible Window of High Fat Diet/Bisphenol A Programming of Breast Cancer Risk Role:PI $1,790,100.00 Active Level:Federal
Grant: #RC4 ES019755 Investigators:Chen, Aimin; Dietrich, Kim; Ho, Shuk Mei; Reponen, Tiina 09-27-2010 -09-30-2013 National Institute of Environmental Health Sciences Human Developmental Toxicity of Metal Mixture Exposure from E-Waste Recycling Role:Collaborator $1,722,932.00 Active Level:Federal
Grant: #W81XWH-11-1-0323 Investigators:Ho, Shuk Mei; Isaac, Jared; Waltz, Susan 04-01-2011 -07-20-2012 Department of the Army Medical Research Acquisition Activity Investigation of S-Nitrosylation of Integrin Alpha 6 in Prostate Cancer Metastasis Role:PI $38,979.81 Closed Level:Federal
Grant: #VA IPA Ouyang Investigators:Ho, Shuk Mei; Ouyang, Bin 04-01-2011 -03-31-2014 Department of Veterans Affairs Intergovernmental Personnel Act Agreement for Bin Ouyang Role:Collaborator $190,210.85 Active Level:Federal
Grant: #R21 CA156042 Investigators:Ho, Shuk Mei; Levin, Linda; Medvedovic, Mario; Tam, Neville Ngai Chung 08-01-2011 -07-31-2014 National Cancer Institute Gene Methylation Targets for Prostate Cancer Prevention by Early Soy Exposure Role:Collaborator $375,623.00 Active Level:Federal
Grant: #U01ES020988 Investigators:Ho, Shuk Mei; Kendler, Ady; Leung, Yuet Kin; Medvedovic, Mario 09-19-2011 -05-31-2015 National Institute of Environmental Health Sciences Chronic Exposure to Bisphenol A and Uterine Cancer Risk Markers Role:PI $524,179.00 Active Level:Federal
Grant: #2011-04282-01-00 / U01ES020886 Investigators:Ho, Shuk Mei 06-01-2012 -05-31-2015 National Institute of Environmental Health Sciences Prostatic Effects of Chronic Exposure to Bisphenol A in Rat Model Role:PI $82,353.00 Active Level:Federal
Grant: #R21EB012122 Investigators:Ho, Shuk Mei; Lee, Jing-Huei; Smithrud, David 04-01-2012 -03-31-2014 National Institute of Biomedical Imaging and Bioengineering Smart, Enzyme-Activated MRI Contrast Agents for Cancer Detection Role:Collaborator $379,077.00 Active Level:Federal
Grant: #S10OD011944 Investigators:Adler, Caleb; Clark, Joseph; Ho, Shuk Mei; Howarth, Jack; Komoroski, Richard; Lu, Aigang; Pyne-Geithman, Gail Jean; Rosevear, Paul; Strakowski, Stephen 04-02-2012 -03-31-2014 Office of the Director, National Institutes of Health Bruker Avance III Wide-Bore (89-mm, 9.4T), Vertical-Bore 400-Mhz NMR Spectrometer Role:Collaborator $595,000.00 Active Level:Federal
Grant: #PO # 415923-G \ ES001247 Investigators:Haynes, Erin; Ho, Shuk Mei 07-25-2012 -09-30-2013 National Institute of Environmental Health Sciences Health and Hydrofracking: Comparative Assessment of Community Information Needs Role:PI $39,250.00 Active Level:Federal
Grant: #2012-02586-01-00 \ R01ES022071 Investigators:Ho, Shuk Mei; Leung, Yuet Kin; Medvedovic, Mario 08-23-2012 -04-30-2017 National Institute of Environmental Health Sciences Effects of Arsenic on Human Prostate Stem Cells and Prostate Cancer Risk Role:PI $154,665.00 Active Level:Federal
Grant: #11212355057091/ R01ES021477 Investigators:Ho, Shuk Mei; Leung, Yuet Kin; Medvedovic, Mario 02-01-2013 -10-31-2013 National Institute of Environmental Health Sciences Glucose Metabolism in Adults Prenatally Exposed to Diabetogenic Pollutants Role:PI $32,671.00 Active Level:Federal
Grant: #P30ES006096 Investigators:Caruso, Joseph; Chen, Aimin; Deka, Ranjan; Greis, Kenneth; Haynes, Erin; Ho, Shuk Mei; Lemasters, Grace; Leung, Yuet Kin; Medvedovic, Mario; Meller, Jaroslaw; Meloncon, Lisa; Pinney, Susan; Porollo, Alexey; Puga, Alvaro; Thomas, Michael; Woo, Daniel; Yadav, Jagjit; Yancey, Elissa 04-01-2013 -03-31-2018 National Institute of Environmental Health Sciences Environmental Genetics Role:PI $1,743,768.00 Active Level:Federal
Grant: #15-038 / R21ES025406-01 Investigators:Ho, Shuk Mei 04-09-2015 -03-31-2017 National Institute of Environmental Health Sciences Epigenomic effects of perinatal exposure to environmental estrogens promote the development of allergic asthma Role:PI $57,693.00 Active Level:Federal
Grant: #R56 HL130042 Investigators:Ho, Shuk Mei; Leung, Yuet Kin; Wang, Yi-Gang; Xu, Meifeng 09-15-2016 -08-31-2017 National Heart, Lung and Blood Institute Autologous Cardiomyocytes from Masseter Muscles to Repair Myocardial Infarction Role:Collaborator $472,965.00 Active Level:Federal
Grant: #R01 HL138481 Investigators:Gupta, Nishant; Ho, Shuk Mei; McCormack, Francis; Yu, Jane 08-01-2017 -06-30-2020 National Heart, Lung and Blood Institute Targeting prostaglandin biosynthesis and action in lymphangioleiomyomatosis Role:Collaborator $651,071.00 Awarded Level:Federal
Grant: #P30ES006096 Investigators:Ho, Shuk Mei 04-01-2018 -03-31-2023 National Institute of Environmental Health Sciences Center for Environmental Genetics Role:PI $1,613,566.00 Awarded Level:Federal
Grant: #W81XWH-18-1-0609 Investigators:Ho, Shuk Mei; Kotagiri, Nalinikanth; Mahoney, Mary 09-01-2018 -08-31-2021 Department of the Army Radionuclide activated precision phototherapy of metastatic breast cancer Role:Collaborator $601,303.00 Awarded Level:Federal
Grant: #R21ES023507 Investigators:Ho, Shuk-Mei; Puga, Alvaro; Xia, Ying 07-01-2014 -06-30-2017 National Institute of Environmental Health Sciences Gene-Environment Interactions in Eyelid Morphogenesis Role:Collaborator $435,250.00 Closed Level:Federal
Publications
Peer Reviewed Publications
Govindarajah, Vinothini; Leung, Yuet-Kin; Ying, Jun; Gear, Robin; Bornschein, Robert L; Medvedovic, Mario; Ho, Shuk-Mei (2016. ) In utero exposure of rats to high-fat diets perturbs gene expression profiles and cancer susceptibility of prepubertal mammary glands.The Journal of nutritional biochemistry, , 29 ,73-82 More Information
Seachrist, Darcie D; Bonk, Kristen W; Ho, Shuk-Mei; Prins, Gail S; Soto, Ana M; Keri, Ruth A (2016. ) A review of the carcinogenic potential of bisphenol A.Reproductive toxicology (Elmsford, N.Y.), , 59 ,167-82 More Information
Panchanathan, Ravichandran; Liu, Hongzhu; Leung, Yuet-Kin; Ho, Shuk-mei; Choubey, Divaker (2015. ) Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells.Molecular and cellular endocrinology, , 415 ,45-55 More Information
Ho, Shuk-Mei; Cheong, Ana; Lam, Hung-Ming; Hu, Wen-Yang; Shi, Guang-Bin; Zhu, Xuegong; Chen, Jing; Zhang, Xiang; Medvedovic, Mario; Leung, Yuet-Kin; Prins, Gail S (2015. ) Exposure of Human Prostaspheres to Bisphenol A Epigenetically Regulates SNORD Family Noncoding RNAs via Histone Modification.Endocrinology, , 156 (11 ) ,3984-95 More Information
Prins, Gail S; Hu, Wen-Yang; Shi, Guang-Bin; Hu, Dan-Ping; Majumdar, Shyama; Li, Guannan; Huang, Ke; Nelles, Jason L; Ho, Shuk-Mei; Walker, Cheryl Lyn; Kajdacsy-Balla, Andre; van Breemen, Richard B (2014. ) Bisphenol A promotes human prostate stem-progenitor cell self-renewal and increases in vivo carcinogenesis in human prostate epithelium.Endocrinology, , 155 (3 ) ,805-17 More Information
Lam, Hung-Ming; Ouyang, Bin; Chen, Jing; Ying, Jun; Wang, Jiang; Wu, Chin-Lee; Jia, Li; Medvedovic, Mario; Vessella, Robert L; Ho, Shuk-Mei (2014. ) Targeting GPR30 with G-1: a new therapeutic target for castration-resistant prostate cancer.Endocrine-related cancer, , 21 (6 ) ,903-14 More Information
Tarapore, Pheruza; Ying, Jun; Ouyang, Bin; Burke, Barbara; Bracken, Bruce; Ho, Shuk-Mei (2014. ) Exposure to bisphenol A correlates with early-onset prostate cancer and promotes centrosome amplification and anchorage-independent growth in vitro.PloS one, , 9 (3 ) ,e90332 More Information
Lee, Ming-Tsung; Ho, Shuk-Mei; Tarapore, Pheruza; Chung, Irving; Leung, Yuet-Kin (2013. ) Estrogen receptor ? isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12. Neoplasia (New York, N.Y.), , 15 (11 ) ,1262-71
Lee, Ming-Tsung; Ouyang, Bin; Ho, Shuk-Mei; Leung, Yuet-Kin (2013. ) Differential expression of estrogen receptor beta isoforms in prostate cancer through interplay between transcriptional and translational regulation.Molecular and cellular endocrinology, , 376 (1-2 ) ,125-35 More Information
Jin, Chang; Chen, Jing; Meng, Qinghang; Carreira, Vinicius; Tam, Neville N C; Geh, Esmond; Karyala, Saikumar; Ho, Shuk-Mei; Zhou, Xiangtian; Medvedovic, Mario; Xia, Ying (2013. ) Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis.Developmental biology, , 374 (1 ) ,96-107 More Information
Brunst, Kelly J; Leung, Yuet-Kin; Ryan, Patrick H; Khurana Hershey, Gurjit K; Levin, Linda; Ji, Hong; Lemasters, Grace K; Ho, Shuk-Mei (2013. ) Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma.The Journal of allergy and clinical immunology, , 131 (2 ) ,592-4.e1-3 More Information
Chu, Sophie; Zhang, Hanjie; Maher, Christina; McDonald, Jacob D; Zhang, Xiang; Ho, Shuk-Mei; Yan, Beizhan; Chillrud, Steven; Perera, Frederica; Factor, Phillip; Miller, Rachel L (2013. ) Prenatal and postnatal polycyclic aromatic hydrocarbon exposure, airway hyperreactivity, and Beta-2 adrenergic receptor function in sensitized mouse offspring.Journal of toxicology, , 2013 ,603581 More Information
Ouyang, Bin; Baxter, C Stuart; Lam, Hung-Ming; Yeramaneni, Samrat; Levin, Linda; Haynes, Erin; Ho, Shuk-Mei (2012. ) Hypomethylation of dual specificity phosphatase 22 promoter correlates with duration of service in firefighters and is inducible by low-dose benzo[a]pyrene.Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine, , 54 (7 ) ,774-80 More Information
Walker, Cheryl Lyn; Ho, Shuk-mei (2012. ) Developmental reprogramming of cancer susceptibility.Nature reviews. Cancer, , 12 (7 ) ,479-86 More Information
Ho, Shuk-Mei; Lee, Ming-Tsung; Lam, Hung-Ming; Leung, Yuet-Kin (2011. ) Estrogens and prostate cancer: etiology, mediators, prevention, and management.Endocrinology and metabolism clinics of North America, , 40 (3 ) ,591-614, ix More Information
Hu, Wen-Yang; Shi, Guang-Bin; Lam, Hung-Ming; Hu, Dan-Ping; Ho, Shuk-Mei; Madueke, Ikenna C; Kajdacsy-Balla, Andre; Prins, Gail S (2011. ) Estrogen-initiated transformation of prostate epithelium derived from normal human prostate stem-progenitor cells.Endocrinology, , 152 (6 ) ,2150-63 More Information
Tarapore, Pheruza; Shu, Yi; Guo, Peixuan; Ho, Shuk-Mei (2011. ) Application of phi29 motor pRNA for targeted therapeutic delivery of siRNA silencing metallothionein-IIA and survivin in ovarian cancers.Molecular therapy : the journal of the American Society of Gene Therapy, , 19 (2 ) ,386-94 More Information
Prins, Gail S; Ye, Shu-Hua; Birch, Lynn; Ho, Shuk-mei; Kannan, Kurunthachalam (2011. ) Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague-Dawley rats.Reproductive toxicology (Elmsford, N.Y.), , 31 (1 ) ,1-9 More Information
Marston, D A; McElhinney, L M; Ali, Y H; Intisar, K S; Ho, S M; Freuling, C; Müller, T; Fooks, A R (2009. ) Phylogenetic analysis of rabies viruses from Sudan provides evidence of a viral clade with a unique molecular signature.Virus research, , 145 (2 ) ,244-50 More Information
Xiong, Su Dao; Yu, Kang; Liu, Xin Hua; Yin, Li Hui; Kirschenbaum, Alexander; Yao, Shen; Narla, Goutham; DiFeo, Analisa; Wu, Jian Buo; Yuan, Yong; Ho, Shuk-Mei; Lam, Ying Wai; Levine, Alice C (2009. ) Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells.International journal of cancer, , 125 (4 ) ,774-82 More Information
Myers, John Peterson; vom Saal, Frederick S; Akingbemi, Benson T; Arizono, Koji; Belcher, Scott; Colborn, Theo; Chahoud, Ibrahim; Crain, D Andrew; Farabollini, Francesca; Guillette, Louis J; Hassold, Terry; Ho, Shuk-mei; Hunt, Patricia A; Iguchi, Taisen; Jobling, Susan; Kanno, Jun; Laufer, Hans; Marcus, Michele; McLachlan, John A; Nadal, Angel; Oehlmann, Jörg; Olea, Nicolás; Palanza, Paola; Parmigiani, Stefano; Rubin, Beverly S; Schoenfelder, Gilbert; Sonnenschein, Carlos; Soto, Ana M; Talsness, Chris E; Taylor, Julia A; Vandenberg, Laura N; Vandenbergh, John G; Vogel, Sarah; Watson, Cheryl S; Welshons, Wade V; Zoeller, R Thomas (2009. ) Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A.Environmental health perspectives, , 117 (3 ) ,309-15 More Information
Schiewer, M J; Morey, L M; Burd, C J; Liu, Y; Merry, D E; Ho, S-M; Knudsen, K E (2009. ) Cyclin D1 repressor domain mediates proliferation and survival in prostate cancer.Oncogene, , 28 (7 ) ,1016-27 More Information
Perera, Frederica; Tang, Wan-yee; Herbstman, Julie; Tang, Deliang; Levin, Linda; Miller, Rachel; Ho, Shuk-mei (2009. ) Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma.PloS one, , 4 (2 ) ,e4488 More Information
Prins, Gail S; Tang, Wan-Yee; Belmonte, Jessica; Ho, Shuk-Mei (2008. ) Perinatal exposure to oestradiol and bisphenol A alters the prostate epigenome and increases susceptibility to carcinogenesis.Basic & clinical pharmacology & toxicology, , 102 (2 ) ,134-8 More Information
Choubey, Divaker; Deka, Ranjan; Ho, Shuk-mei (2008. ) Interferon-inducible IFI16 protein in human cancers and autoimmune diseases. Frontiers in bioscience : a journal and virtual library, , 13 ,598-608
Tam, Neville N C; Szeto, Carol Ying-Ying; Sartor, Maureen A; Medvedovic, Mario; Ho, Shuk-Mei (2008. ) Gene expression profiling identifies lobe-specific and common disruptions of multiple gene networks in testosterone-supported, 17beta-estradiol- or diethylstilbestrol-induced prostate dysplasia in Noble rats. Neoplasia (New York, N.Y.), , 10 (1 ) ,20-40
Tam, Neville N C; Leav, Irwin; Ho, Shuk-Mei (2007. ) Sex hormones induce direct epithelial and inflammation-mediated oxidative/nitrosative stress that favors prostatic carcinogenesis in the noble rat.The American journal of pathology, , 171 (4 ) ,1334-41 More Information
vom Saal, Frederick S; Akingbemi, Benson T; Belcher, Scott M; Birnbaum, Linda S; Crain, D Andrew; Eriksen, Marcus; Farabollini, Francesca; Guillette, Louis J; Hauser, Russ; Heindel, Jerrold J; Ho, Shuk-Mei; Hunt, Patricia A; Iguchi, Taisen; Jobling, Susan; Kanno, Jun; Keri, Ruth A; Knudsen, Karen E; Laufer, Hans; LeBlanc, Gerald A; Marcus, Michele; McLachlan, John A; Myers, John Peterson; Nadal, Angel; Newbold, Retha R; Olea, Nicolas; Prins, Gail S; Richter, Catherine A; Rubin, Beverly S; Sonnenschein, Carlos; Soto, Ana M; Talsness, Chris E; Vandenbergh, John G; Vandenberg, Laura N; Walser-Kuntz, Debby R; Watson, Cheryl S; Welshons, Wade V; Wetherill, Yelena; Zoeller, R Thomas Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure.Reproductive toxicology (Elmsford, N.Y.), , 24 (2 ) ,131-8 More Information
Keri, Ruth A; Ho, Shuk-Mei; Hunt, Patricia A; Knudsen, Karen E; Soto, Ana M; Prins, Gail S An evaluation of evidence for the carcinogenic activity of bisphenol A.Reproductive toxicology (Elmsford, N.Y.), , 24 (2 ) ,240-52 More Information
Languino, Lucia R; Ho, Shuk-Mei (2006. ) Androgen action series. Journal of cellular biochemistry, , 99 (2 ) ,331-2
Leung, Yuet-Kin; Mak, Paul; Hassan, Sazzad; Ho, Shuk-Mei (2006. ) Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling.Proceedings of the National Academy of Sciences of the United States of America, , 103 (35 ) ,13162-7 More Information
Ho, Shuk-Mei; Tang, Wan-Yee; Belmonte de Frausto, Jessica; Prins, Gail S (2006. ) Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4.Cancer research, , 66 (11 ) ,5624-32 More Information
Leung, Yuet-Kin; Gao, Ying; Lau, Kin-Mang; Zhang, Xiang; Ho, Shuk-Mei (2006. ) ICI 182,780-regulated gene expression in DU145 prostate cancer cells is mediated by estrogen receptor-beta/NFkappaB crosstalk.Neoplasia (New York, N.Y.), , 8 (4 ) ,242-9 More Information
Kim, Jeri; Sun, Peiyu; Lam, Ying-Wai; Troncoso, Patricia; Sabichi, Anita L; Babaian, Richard J; Pisters, Louis L; Pettaway, Curtis A; Wood, Christopher G; Lippman, Scott M; McDonnell, Timothy J; Lieberman, Ronald; Logothetis, Christopher; Ho, Shuk-Mei (2005. ) Changes in serum proteomic patterns by presurgical alpha-tocopherol and L-selenomethionine supplementation in prostate cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , 14 (7 ) ,1697-702 More Information
Mukherjee, Kasturi; Syed, Viqar; Ho, Shuk-Mei (2005. ) Estrogen-induced loss of progesterone receptor expression in normal and malignant ovarian surface epithelial cells.Oncogene, , 24 (27 ) ,4388-400 More Information
Syed, Viqar; Mukherjee, Kasturi; Lyons-Weiler, James; Lau, Kin-Mang; Mashima, Tetsuo; Tsuruo, Takashi; Ho, Shuk-mei (2005. ) Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling.Oncogene, , 24 (10 ) ,1774-87 More Information
Wu, Mengchu; Ho, Shuk-Mei (2004. ) PMP24, a gene identified by MSRF, undergoes DNA hypermethylation-associated gene silencing during cancer progression in an LNCaP model.Oncogene, , 23 (1 ) ,250-9 More Information
Syed, Viqar; Ho, Shuk-Mei (2003. ) Progesterone-induced apoptosis in immortalized normal and malignant human ovarian surface epithelial cells involves enhanced expression of FasL.Oncogene, , 22 (44 ) ,6883-90 More Information
Mobley, James A; Leav, Irwin; Zielie, Patrick; Wotkowitz, Chad; Evans, James; Lam, Ying-Wai; L'Esperance, Byung Suk; Jiang, Zhong; Ho, Shuk-Mei (2003. ) Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , 12 (8 ) ,775-83
Ho, Shuk-Mei; Lau, Kin-Mang; Mok, Samuel Chi-Ho; Syed, Viqar (2003. ) Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells.Oncogene, , 22 (27 ) ,4243-56 More Information
Lau, Kin-Mang; Tam, Neville N C; Thompson, Christopher; Cheng, Robert Y S; Leung, Yuet-Kin; Ho, Shuk-Mei (2003. ) Age-associated changes in histology and gene-expression profile in the rat ventral prostate. Laboratory investigation; a journal of technical methods and pathology, , 83 (5 ) ,743-57
Thompson, Christopher J; Tam, Neville N C; Joyce, Jennifer M; Leav, Irwin; Ho, Shuk-Mei (2002. ) Gene expression profiling of testosterone and estradiol-17 beta-induced prostatic dysplasia in Noble rats and response to the antiestrogen ICI 182,780.Endocrinology, , 143 (6 ) ,2093-105 More Information
Syed, Viqar; Ulinski, Gregory; Mok, Samuel C; Ho, Shuk-Mei (2002. ) Reproductive hormone-induced, STAT3-mediated interleukin 6 action in normal and malignant human ovarian surface epithelial cells. Journal of the National Cancer Institute, , 94 (8 ) ,617-29
Ho, Shuk-Mei; Lau, Kin-Mang (2002. ) DNA microarrays in prostate cancer. Current urology reports, , 3 (1 ) ,53-60
Li, S C; Chen, G F; Chan, P S; Choi, H L; Ho, S M; Chan, F L (2001. ) Altered expression of extracellular matrix and proteinases in Noble rat prostate gland after long-term treatment with sex steroids. The Prostate, , 49 (1 ) ,58-71
Leav, I; Lau, K M; Adams, J Y; McNeal, J E; Taplin, M E; Wang, J; Singh, H; Ho, S M (2001. ) Comparative studies of the estrogen receptors beta and alpha and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma. The American journal of pathology, , 159 (1 ) ,79-92
Chan, F L; Choi, H L; Ho, S M (2001. ) Analysis of glycoconjugate patterns of normal and hormone-induced dysplastic Noble rat prostates, and an androgen-independent Noble rat prostate tumor, by lectin histochemistry and protein blotting. The Prostate, , 46 (1 ) ,21-32
Kwong, J; Xuan, J W; Chan, P S; Ho, S M; Chan, F L (2000. ) A comparative study of hormonal regulation of three secretory proteins (prostatic secretory protein-PSP94, probasin, and seminal vesicle secretion II) in rat lateral prostate.Endocrinology, , 141 (12 ) ,4543-51 More Information
Rauh-Adelmann, C; Lau, K M; Sabeti, N; Long, J P; Mok, S C; Ho, S M (2000. ) Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines. Molecular carcinogenesis, , 28 (4 ) ,236-46
Chan, F L; Ho, S M (1999. ) Comparative study of glycoconjugates of the rat prostatic lobes by lectin histochemistry. The Prostate, , 38 (1 ) ,1-16
Ho, S M; Leav, I; Ghatak, S; Merk, F; Jagannathan, V S; Mallery, K (1998. ) Lack of association between enhanced TRPM-2/clusterin expression and increased apoptotic activity in sex-hormone-induced prostatic dysplasia of the Noble rat.The American journal of pathology, , 153 (1 ) ,131-9 More Information
Lau, K M; Leav, I; Ho, S M (1998. ) Rat estrogen receptor-alpha and -beta, and progesterone receptor mRNA expression in various prostatic lobes and microdissected normal and dysplastic epithelial tissues of the Noble rats.Endocrinology, , 139 (1 ) ,424-7 More Information
Lane, K E; Ricci, M J; Ho, S M (1997. ) Effect of combined testosterone and estradiol-17 beta treatment on the metabolism of E2 in the prostate and liver of noble rats. The Prostate, , 30 (4 ) ,256-62
Bosland, M C; Chung, L W; Greenberg, N M; Ho, S M; Isaacs, J T; Lane, K; Peehl, D M; Thompson, T C; van Steenbrugge, G J; van Weerden, W M Recent advances in the development of animal and cell culture models for prostate cancer research A minireview. Urologic oncology, , 2 (4 ) ,99
Ho, S M; Yu, M (1993. ) Selective increase in type II estrogen-binding sites in the dysplastic dorsolateral prostates of noble rats. Cancer research, , 53 (3 ) ,528-32
Ho, S M (1991. ) Prostatic androgen receptor and plasma testosterone levels in streptozotocin-induced diabetic rats. The Journal of steroid biochemistry and molecular biology, , 38 (1 ) ,67-72
Ho, S M; Press, D; Yu, M S (1989. ) Effects of hypophysectomy and ovariectomy on hepatic estrogen receptor content in the turtle, Chrysemys picta. General and comparative endocrinology, , 75 (3 ) ,466-71
Leav, I; Ho, S M; Ofner, P; Merk, F B; Kwan, P W; Damassa, D (1988. ) Biochemical alterations in sex hormone-induced hyperplasia and dysplasia of the dorsolateral prostates of Noble rats. Journal of the National Cancer Institute, , 80 (13 ) ,1045-53
Ho, S M; Lance, V; Megaloudis, M (1987. ) Plasma sex-steroid binding protein in a seasonally breeding reptile, Alligator mississippiensis. General and comparative endocrinology, , 65 (1 ) ,121-32
Ho, S M; Levin, V (1986. ) Induction of progesterone receptor by androgens in the mouse uterus. Molecular and cellular endocrinology, , 46 (2 ) ,103-8
Ho, S M; Ofner, P (1986. ) Prostatic cytosol binding of 5 alpha-androstane-3 beta, 17 beta-diol and estradiol-17 beta. Steroids, , 47 (1 ) ,21-34
Hecht, N B; Liem, H; Kleene, K C; Distel, R J; Ho, S M (1984. ) Maternal inheritance of the mouse mitochondrial genome is not mediated by a loss or gross alteration of the paternal mitochondrial DNA or by methylation of the oocyte mitochondrial DNA. Developmental biology, , 102 (2 ) ,452-61
Mak, P; Ho, S M; Callard, I P (1983. ) Characterization of an estrogen receptor in the turtle testis. General and comparative endocrinology, , 52 (2 ) ,182-9
Ho, S M; Danko, D; Callard, I P (1981. ) Effect of exogenous estradiol-17beta on plasma vitellogenin levels in male and female Chrysemys and its modulation by testosterone and progesterone. General and comparative endocrinology, , 43 (4 ) ,413-21
Ho, S M; Tsang, P; Callard, I P (1980. ) Some properties of a steroid-binding protein in the plasma of an ovoviviparous dogfish, Squalus acanthias, at different stages of the life cycle. Biology of reproduction, , 23 (2 ) ,281-9
Miller, Marian; Bailey, Banita; Govindarajah, Vinothini; Levin, Linda; Metzger, Traci; Pinney, Susan M; Leung, Yuet-Kin; Ho, Shuk-Mei (2016. ) A community survey on knowledge of the impact of environmental and epigenetic factors on health and disease.Perspectives in public health, , More Information
Ho, Shuk-Mei; Tam, Neville Ngai Chung (2015. ) Organoid model shows effect of BPA on prostate development.Nature reviews. Urology, , 12 (12 ) ,658-9 More Information
Yang, Shuman; Pinney, Susan M; Mallick, Palash; Ho, Shuk-Mei; Bracken, Bruce; Wu, Tianying (2015. ) Impact of Oxidative Stress Biomarkers and Carboxymethyllysine (an Advanced Glycation End Product) on Prostate Cancer: A Prospective Study.Clinical genitourinary cancer, , 13 (5 ) ,e347-51 More Information
Tam, Neville Ngai-Chung; Zhang, Xiang; Xiao, Hong; Song, Dan; Levin, Linda; Meller, Jarek; Ho, Shuk-Mei (2015. ) Increased susceptibility of estrogen-induced bladder outlet obstruction in a novel mouse model.Laboratory investigation; a journal of technical methods and pathology, , 95 (5 ) ,546-60 More Information
Yang, Won Seok; Chadalapaka, Gayathri; Cho, Sung-Gook; Lee, Syng-Ook; Jin, Un-Ho; Jutooru, Indira; Choi, Kwangmin; Leung, Yuet-Kin; Ho, Shuk-Mei; Safe, Stephen; Kim, Kyounghyun (2014. ) The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis.Neoplasia (New York, N.Y.), , 16 (12 ) ,1059-69 More Information
Langevin, Scott M; Pinney, Susan M; Leung, Yuet-Kin; Ho, Shuk-Mei (2014. ) Does epigenetic drift contribute to age-related increases in breast cancer risk?.Epigenomics, , 6 (4 ) ,367-9 More Information
Leung, Yuet-Kin; Chan, Queeny Kwan-Yi; Ng, Chi-Fai; Ma, Fanny Man-Ting; Tse, Ho-Man; To, Ka-Fai; Maranchie, Jodi; Ho, Shuk-Mei; Lau, Kin-Mang (2014. ) Hsa-miRNA-765 as a key mediator for inhibiting growth, migration and invasion in fulvestrant-treated prostate cancer.PloS one, , 9 (5 ) ,e98037 More Information
Wu, Tianying; Wang, Yushan; Ho, Shuk-Mei; Giovannucci, Edward (2013. ) Plasma levels of nitrate and risk of prostate cancer: a prospective study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , 22 (7 ) ,1210-8 More Information
Ouyang, Bin; Bernstein, David I; Lummus, Zana L; Ying, Jun; Boulet, Louis-Philippe; Cartier, André; Gautrin, Denyse; Ho, Shuk-Mei (2013. ) Interferon-? promoter is hypermethylated in blood DNA from workers with confirmed diisocyanate asthma.Toxicological sciences : an official journal of the Society of Toxicology, , 133 (2 ) ,218-24 More Information
Chen, Aimin; Park, June-Soo; Linderholm, Linda; Rhee, Alexandra; Petreas, Myrto; DeFranco, Emily A; Dietrich, Kim N; Ho, Shuk-Mei (2013. ) Hydroxylated polybrominated diphenyl ethers in paired maternal and cord sera.Environmental science & technology, , 47 (8 ) ,3902-8 More Information
Tang, Wan-yee; Levin, Linda; Talaska, Glenn; Cheung, Yuk Yin; Herbstman, Julie; Tang, Deliang; Miller, Rachel L; Perera, Frederica; Ho, Shuk-Mei (2012. ) Maternal exposure to polycyclic aromatic hydrocarbons and 5'-CpG methylation of interferon-? in cord white blood cells.Environmental health perspectives, , 120 (8 ) ,1195-200 More Information
Lam, Hung-Ming; Suresh Babu, C V; Wang, Jiang; Yuan, Yong; Lam, Ying-Wai; Ho, Shuk-Mei; Leung, Yuet-Kin (2012. ) Phosphorylation of human estrogen receptor-beta at serine 105 inhibits breast cancer cell migration and invasion.Molecular and cellular endocrinology, , 358 (1 ) ,27-35 More Information
Zhang, Xiang; Ho, Shuk-Mei (2011. ) Epigenetics meets endocrinology. Journal of molecular endocrinology, , 46 (1 ) ,R11-32
Howard, Timothy D; Ho, Shuk-Mei; Zhang, Li; Chen, Jing; Cui, Wei; Slager, Rebecca; Gray, Stanton; Hawkins, Gregory A; Medvedovic, Mario; Wagner, Janice D (2011. ) Epigenetic changes with dietary soy in cynomolgus monkeys.PloS one, , 6 (10 ) ,e26791 More Information
Prins, G S; Ho, S-M (2010. ) Early-life estrogens and prostate cancer in an animal model.Journal of developmental origins of health and disease, , 1 (6 ) ,365-70 More Information
Ho, Shuk-Mei (2010. ) Environmental epigenetics of asthma: an update.The Journal of allergy and clinical immunology, , 126 (3 ) ,453-65 More Information
Leung, Yuet-Kin; Lam, Hung-Ming; Wu, Shulin; Song, Dan; Levin, Linda; Cheng, Liang; Wu, Chin-Lee; Ho, Shuk-Mei (2010. ) Estrogen receptor beta2 and beta5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion.Endocrine-related cancer, , 17 (3 ) ,675-89 More Information
Joseph, Doina; Ho, Shuk-Mei; Syed, Viqar (2010. ) Hormonal regulation and distinct functions of semaphorin-3B and semaphorin-3F in ovarian cancer.Molecular cancer therapeutics, , 9 (2 ) ,499-509 More Information
Zhang, Xiang; Leav, Irwin; Revelo, Monica P; Deka, Ranjan; Medvedovic, Mario; Jiang, Zhong; Ho, Shuk-Mei (2009. ) Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon.PLoS genetics, , 5 (1 ) ,e1000334 More Information
Tang, Wan-Yee; Newbold, Retha; Mardilovich, Katerina; Jefferson, Wendy; Cheng, Robert Y S; Medvedovic, Mario; Ho, Shuk-Mei (2008. ) Persistent hypomethylation in the promoter of nucleosomal binding protein 1 (Nsbp1) correlates with overexpression of Nsbp1 in mouse uteri neonatally exposed to diethylstilbestrol or genistein.Endocrinology, , 149 (12 ) ,5922-31 More Information
Lam, Ying Wai; Tam, Neville N C; Evans, James E; Green, Karin M; Zhang, Xiang; Ho, Shuk-Mei (2008. ) Differential proteomics in the aging Noble rat ventral prostate.Proteomics, , 8 (13 ) ,2750-63 More Information
Syed, Viqar; Mukherjee, Kasturi; Godoy-Tundidor, Sonia; Ho, Shuk-Mei (2007. ) Progesterone induces apoptosis in TRAIL-resistant ovarian cancer cells by circumventing c-FLIPL overexpression.Journal of cellular biochemistry, , 102 (2 ) ,442-52 More Information
Ho, Shuk-mei; Tang, Wan-yee Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseases.Reproductive toxicology (Elmsford, N.Y.), , 23 (3 ) ,267-82 More Information
Mak, Paul; Leung, Yuet-Kin; Tang, Wan-Yee; Harwood, Charlotte; Ho, Shuk-Mei (2006. ) Apigenin suppresses cancer cell growth through ERbeta.Neoplasia (New York, N.Y.), , 8 (11 ) ,896-904 More Information
Tam, Neville N C; Nyska, Abraham; Maronpot, Robert R; Kissling, Grace; Lomnitski, Liat; Suttie, Andrew; Bakshi, Shlomo; Bergman, Margalit; Grossman, Shlomo; Ho, Shuk-Mei (2006. ) Differential attenuation of oxidative/nitrosative injuries in early prostatic neoplastic lesions in TRAMP mice by dietary antioxidants.The Prostate, , 66 (1 ) ,57-69 More Information
Syed, Viqar; Zhang, Xiang; Lau, Kin-Mang; Cheng, Robert; Mukherjee, Kasturi; Ho, Shuk-Mei (2005. ) Profiling estrogen-regulated gene expression changes in normal and malignant human ovarian surface epithelial cells.Oncogene, , 24 (55 ) ,8128-43 More Information
Ho, Shuk-mei; Cheng, Robert Y S (2004. ) A promising bladder cancer detection assay: the HA-HAase test.The Journal of urology, , 172 (3 ) ,824-5 More Information
Zhu, Xuegong; Leav, Irwin; Leung, Yuet-Kin; Wu, Mengchu; Liu, Qin; Gao, Ying; McNeal, John E; Ho, Shuk-Mei (2004. ) Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis. The American journal of pathology, , 164 (6 ) ,2003-12
Tam, Neville N C; Gao, Ying; Leung, Yuet-Kin; Ho, Shuk-Mei (2003. ) Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowth.The American journal of pathology, , 163 (6 ) ,2513-22 More Information
Ho, Shuk-Mei (2003. ) Estrogen, progesterone and epithelial ovarian cancer.Reproductive biology and endocrinology : RB&E, , 1 ,73 More Information
Syed, V; Ulinski, G; Mok, S C; Yiu, G K; Ho, S M (2001. ) Expression of gonadotropin receptor and growth responses to key reproductive hormones in normal and malignant human ovarian surface epithelial cells. Cancer research, , 61 (18 ) ,6768-76
Tekur, S; Lau, K M; Long, J; Burnstein, K; Ho, S M (2001. ) Expression of RFG/ELE1alpha/ARA70 in normal and malignant prostatic epithelial cell cultures and lines: regulation by methylation and sex steroids. Molecular carcinogenesis, , 30 (1 ) ,1-13
Lau, K M; Mok, S C; Ho, S M (1999. ) Expression of human estrogen receptor-alpha and -beta, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells. Proceedings of the National Academy of Sciences of the United States of America, , 96 (10 ) ,5722-7
Leav, I; Merk, F B; Lee, K F; Loda, M; Mandoki, M; McNeal, J E; Ho, S M (1999. ) Prolactin receptor expression in the developing human prostate and in hyperplastic, dysplastic, and neoplastic lesions.The American journal of pathology, , 154 (3 ) ,863-70 More Information
Hu, Y F; Lau, K M; Ho, S M; Russo, J (1998. ) Increased expression of estrogen receptor beta in chemically transformed human breast epithelial cells. International journal of oncology, , 12 (6 ) ,1225-8
Leav, I; Galluzzi, C M; Ziar, J; Stork, P J; Ho, S M; Loda, M (1996. ) Mitogen-activated protein kinase and mitogen-activated kinase phosphatase-1 expression in the Noble rat model of sex hormone-induced prostatic dysplasia and carcinoma. Laboratory investigation; a journal of technical methods and pathology, , 75 (3 ) ,361-70
Ghatak, S; Ho, S M (1996. ) Age-related changes in the activities of antioxidant enzymes and lipid peroxidation status in ventral and dorsolateral prostate lobes of noble rats.Biochemical and biophysical research communications, , 222 (2 ) ,362-7 More Information
Yu, M; Leav, B A; Leav, I; Merk, F B; Wolfe, H J; Ho, S M (1993. ) Early alterations in ras protooncogene mRNA expression in testosterone and estradiol-17 beta induced prostatic dysplasia of noble rats. Laboratory investigation; a journal of technical methods and pathology, , 68 (1 ) ,33-44
Yu, M S; Ho, S M (1989. ) Seasonal variation in hepatic binding of estrogen in the turtle, Chrysemys picta. General and comparative endocrinology, , 75 (3 ) ,472-80
Yu, M S; Ho, S M (1989. ) Nuclear acceptor sites for estrogen-receptor complexes in the liver of the turtle, Chrysemys picta. I. Sexual differences, species specificity and hormonal dependency. Molecular and cellular endocrinology, , 61 (1 ) ,37-48
Leav, I; Merk, F B; Kwan, P W; Ho, S M (1989. ) Androgen-supported estrogen-enhanced epithelial proliferation in the prostates of intact Noble rats. The Prostate, , 15 (1 ) ,23-40
Ho, S M; Fehrer, S; Yu, M; Liang, L C; Press, D (1988. ) High-affinity binding of [3H]estradiol-17 beta by an estrogen receptor in the liver of the turtle. General and comparative endocrinology, , 70 (3 ) ,382-94
Ho, S M; Leav, I; Damassa, D; Kwan, P W; Merk, F B; Seto, H S (1988. ) Testosterone-mediated increase in 5 alpha-dihydrotestosterone content, nuclear androgen receptor levels, and cell division in an androgen-independent prostate carcinoma of Noble rats. Cancer research, , 48 (3 ) ,609-14
Ho, S M; Damassa, D; Kwan, P W; Seto, H S; Leav, I Androgen receptor levels and androgen contents in the prostate lobes of intact and testosterone-treated Noble rats. Journal of andrology, , 6 (5 ) ,279-90
Ho, S M; Taylor, S; Callard, I P (1982. ) Effect of hypophysectomy and growth hormone on estrogen-induced vitellogenesis in the freshwater turtle, Chrysemys picta. General and comparative endocrinology, , 48 (2 ) ,254-60
Lam, Hung-Ming; Ho, Shuk-Mei; Chen, Jing; Medvedovic, Mario; Tam, Neville Ngai Chung (2016. ) Bisphenol A Disrupts HNF4?-Regulated Gene Networks Linking to Prostate Preneoplasia and Immune Disruption in Noble Rats.Endocrinology, , 157 (1 ) ,207-19 More Information
Martinez, Alan M; Cheong, Ana; Ying, Jun; Xue, Jingchuan; Kannan, Kurunthachalam; Leung, Yuet-Kin; Thomas, Michael A; Ho, Shuk-Mei (2015. ) Effects of High-Butterfat Diet on Embryo Implantation in Female Rats Exposed to Bisphenol A.Biology of reproduction, , 93 (6 ) ,147 More Information
Yang, Shuman; Giovannucci, Edward; Bracken, Bruce; Ho, Shuk-Mei; Wu, Tianying (2015. ) Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study.BMC urology, , 15 ,85 More Information
Wong, Rebecca Lee Yean; Wang, Quan; Treviño, Lindsey S; Bosland, Maarten C; Chen, Jing; Medvedovic, Mario; Prins, Gail S; Kannan, Kurunthachalam; Ho, Shuk-Mei; Walker, Cheryl Lyn (2015. ) Identification of secretaglobin Scgb2a1 as a target for developmental reprogramming by BPA in the rat prostate.Epigenetics, , 10 (2 ) ,127-34 More Information
Ho, Shuk-Mei (2014. ) Battle against the odds: win with effort, attitude, and perseverance!.Endocrine-related cancer, , 21 (4 ) ,P19-24 More Information
Lee, Ming-Tsung; Leung, Yuet-Kin; Chung, Irving; Tarapore, Pheruza; Ho, Shuk-Mei (2013. ) Estrogen receptor ? (ER?1) transactivation is differentially modulated by the transcriptional coregulator Tip60 in a cis-acting element-dependent manner.The Journal of biological chemistry, , 288 (35 ) ,25038-52 More Information
Isaac, Jared; Tarapore, Pheruza; Zhang, Xiang; Lam, Ying-Wai; Ho, Shuk-Mei (2012. ) Site-specific S-nitrosylation of integrin ?6 increases the extent of prostate cancer cell migration by enhancing integrin ?1 association and weakening adherence to laminin-1.Biochemistry, , 51 (48 ) ,9689-97 More Information
Leung, Yuet-Kin; Lee, Ming-Tsung; Lam, Hung-Ming; Tarapore, Pheruza; Ho, Shuk-Mei (2012. ) Estrogen receptor-beta and breast cancer: translating biology into clinical practice.Steroids, , 77 (7 ) ,727-37 More Information
Greathouse, K Leigh; Bredfeldt, Tiffany; Everitt, Jeffrey I; Lin, Kevin; Berry, Tia; Kannan, Kurunthachalam; Mittelstadt, Megan L; Ho, Shuk-mei; Walker, Cheryl L (2012. ) Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis.Molecular cancer research : MCR, , 10 (4 ) ,546-57 More Information
Tang, Wan-yee; Morey, Lisa M; Cheung, Yuk Yin; Birch, Lynn; Prins, Gail S; Ho, Shuk-mei (2012. ) Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout life.Endocrinology, , 153 (1 ) ,42-55 More Information
Ho, Shuk-Mei; Johnson, Abby; Tarapore, Pheruza; Janakiram, Vinothini; Zhang, Xiang; Leung, Yuet-Kin (2012. ) Environmental epigenetics and its implication on disease risk and health outcomes.ILAR journal / National Research Council, Institute of Laboratory Animal Resources, , 53 (3-4 ) ,289-305 More Information
Privette Vinnedge, Lisa M; Ho, Shuk-Mei; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I (2012. ) The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.PloS one, , 7 (10 ) ,e46985 More Information
Leung, Yuet-Kin; Ho, Shuk-Mei (2011. ) Estrogen receptor ?: switching to a new partner and escaping from estrogen.Science signaling, , 4 (168 ) ,pe19 More Information
Chen, Aimin; Dietrich, Kim N; Huo, Xia; Ho, Shuk-mei (2011. ) Developmental neurotoxicants in e-waste: an emerging health concern.Environmental health perspectives, , 119 (4 ) ,431-8 More Information
Zhou, Qian; Ching, Arthur K-K; Leung, Wilson K-C; Szeto, Carol Y-Y; Ho, Shuk-Mei; Chan, Paul K-S; Yuan, Yun-Fei; Lai, Paul B-S; Yeo, Winnie; Wong, Nathalie (2011. ) Novel therapeutic potential in targeting microtubules by nanoparticle albumin-bound paclitaxel in hepatocellular carcinoma.International journal of oncology, , 38 (3 ) ,721-31 More Information
Ouyang, Bin; Leung, Yuet-Kin; Wang, Vinson; Chung, Ethan; Levin, Linda; Bracken, Bruce; Cheng, Liang; Ho, Shuk-Mei (2011. ) ?-Methylacyl-CoA racemase spliced variants and their expression in normal and malignant prostate tissues.Urology, , 77 (1 ) ,249.e1-7 More Information
Tam, Neville N C; Szeto, Carol Y Y; Freudenberg, Johannes M; Fullenkamp, Amy N; Medvedovic, Mario; Ho, Shuk-Mei (2010. ) Research resource: estrogen-driven prolactin-mediated gene-expression networks in hormone-induced prostatic intraepithelial neoplasia.Molecular endocrinology (Baltimore, Md.), , 24 (11 ) ,2207-17 More Information
Panchanathan, Ravichandran; Shen, Hui; Zhang, Xiang; Ho, Shuk-Mei; Choubey, Divaker (2010. ) Mutually positive regulatory feedback loop between interferons and estrogen receptor-alpha in mice: implications for sex bias in autoimmunity.PloS one, , 5 (5 ) ,e10868 More Information
Lam, Ying Wai; Yuan, Yong; Isaac, Jared; Babu, C V Suresh; Meller, Jarek; Ho, Shuk-Mei (2010. ) Comprehensive identification and modified-site mapping of S-nitrosylated targets in prostate epithelial cells.PloS one, , 5 (2 ) ,e9075 More Information
Curran, Christine P; Park, Robert M; Ho, Shuk-mei; Haynes, Erin N (2009. ) Incorporating genetics and genomics in risk assessment for inhaled manganese: from data to policy.Neurotoxicology, , 30 (5 ) ,754-60 More Information
Ouyang, Bin; Bracken, Bruce; Burke, Barbara; Chung, Ethan; Liang, Juan; Ho, Shuk-Mei (2009. ) A duplex quantitative polymerase chain reaction assay based on quantification of alpha-methylacyl-CoA racemase transcripts and prostate cancer antigen 3 in urine sediments improved diagnostic accuracy for prostate cancer.The Journal of urology, , 181 (6 ) ,2508-13; discussion More Information
Crain, D Andrew; Janssen, Sarah J; Edwards, Thea M; Heindel, Jerrold; Ho, Shuk-mei; Hunt, Patricia; Iguchi, Taisen; Juul, Anders; McLachlan, John A; Schwartz, Jackie; Skakkebaek, Niels; Soto, Ana M; Swan, Shanna; Walker, Cheryl; Woodruff, Teresa K; Woodruff, Tracey J; Giudice, Linda C; Guillette, Louis J (2008. ) Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing.Fertility and sterility, , 90 (4 ) ,911-40 More Information
Prins, Gail S; Tang, Wan-Yee; Belmonte, Jessica; Ho, Shuk-Mei (2008. ) Developmental exposure to bisphenol A increases prostate cancer susceptibility in adult rats: epigenetic mode of action is implicated.Fertility and sterility, , 89 (2 Suppl ) ,e41 More Information
Tam, Neville N C; Ho, Shuk-mei (2008. ) Culture of whole embryonic kidneys: present status and beyond.The Journal of urology, , 179 (1 ) ,17 More Information
Alimirah, Fatouma; Panchanathan, Ravichandran; Chen, Jianming; Zhang, Xiang; Ho, Shuk-Mei; Choubey, Divaker (2007. ) Expression of androgen receptor is negatively regulated by p53. Neoplasia (New York, N.Y.), , 9 (12 ) ,1152-9
Zhang, X; Leung, Y-K; Ho, S-M (2007. ) AP-2 regulates the transcription of estrogen receptor (ER)-beta by acting through a methylation hotspot of the 0N promoter in prostate cancer cells.Oncogene, , 26 (52 ) ,7346-54 More Information
Hess-Wilson, Janet K; Webb, Siobhan L; Daly, Hannah K; Leung, Yuet-Kin; Boldison, Joanne; Comstock, Clay E S; Sartor, Maureen A; Ho, Shuk-Mei; Knudsen, Karen E (2007. ) Unique bisphenol A transcriptome in prostate cancer: novel effects on ERbeta expression that correspond to androgen receptor mutation status.Environmental health perspectives, , 115 (11 ) ,1646-53 More Information
Prins, Gail S; Birch, Lynn; Tang, Wan-Yee; Ho, Shuk-Mei Developmental estrogen exposures predispose to prostate carcinogenesis with aging.Reproductive toxicology (Elmsford, N.Y.), , 23 (3 ) ,374-82 More Information
Ho, Shuk-Mei; Leung, Yuet-Kin; Chung, Irving (2006. ) Estrogens and antiestrogens as etiological factors and therapeutics for prostate cancer.Annals of the New York Academy of Sciences, , 1089 ,177-93 More Information
Sun, Carrie Q; Arnold, Rebecca; Fernandez-Golarz, Carina; Parrish, Amanda B; Almekinder, Tara; He, Ju; Ho, Shuk-mei; Svoboda, Pavel; Pohl, Jan; Marshall, Fray F; Petros, John A (2006. ) Human beta-defensin-1, a potential chromosome 8p tumor suppressor: control of transcription and induction of apoptosis in renal cell carcinoma.Cancer research, , 66 (17 ) ,8542-9 More Information
Lam, Ying Wai; Mobley, James A; Evans, James E; Carmody, James F; Ho, Shuk-Mei (2005. ) Mass profiling-directed isolation and identification of a stage-specific serologic protein biomarker of advanced prostate cancer.Proteomics, , 5 (11 ) ,2927-38 More Information
Leung, Yuet-Kin; Lau, Kin-Mang; Mobley, James; Jiang, Zhong; Ho, Shuk-Mei (2005. ) Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis.Cancer research, , 65 (9 ) ,3726-34 More Information
Bostwick, David G; Burke, Harry B; Djakiew, Daniel; Euling, Susan; Ho, Shuk-mei; Landolph, Joseph; Morrison, Howard; Sonawane, Babasaheb; Shifflett, Tiffany; Waters, David J; Timms, Barry (2004. ) Human prostate cancer risk factors.Cancer, , 101 (10 Suppl ) ,2371-490 More Information
Lai, Janice S; Brown, Lisha G; True, Lawrence D; Hawley, Sarah J; Etzioni, Ruth B; Higano, Celestia S; Ho, Shuk-Mei; Vessella, Robert L; Corey, Eva (2004. ) Metastases of prostate cancer express estrogen receptor-beta.Urology, , 64 (4 ) ,814-20 More Information
Mobley, James A; L'Esperance, James O; Wu, Mengchu; Friel, Carolyn J; Hanson, Robert H; Ho, Shuk-Mei (2004. ) The novel estrogen 17alpha-20Z-21-[(4-amino)phenyl]-19-norpregna-1,3,5(10),20-tetraene-3,17beta-diol induces apoptosis in prostate cancer cell lines at nanomolar concentrations in vitro. Molecular cancer therapeutics, , 3 (5 ) ,587-95
Tam, Neville N C; Ghatak, Shibnath; Ho, Shuk-Mei (2003. ) Sex hormone-induced alterations in the activities of antioxidant enzymes and lipid peroxidation status in the prostate of Noble rats.The Prostate, , 55 (1 ) ,1-8 More Information
Leav, Irwin; McNeal, John E; Ho, Shuk-Mei; Jiang, Zhong (2003. ) Alpha-methylacyl-CoA racemase (P504S) expression in evolving carcinomas within benign prostatic hyperplasia and in cancers of the transition zone.Human pathology, , 34 (3 ) ,228-33 More Information
Adams, Jason Y; Leav, Irwin; Lau, Kin-Mang; Ho, Shuk-Mei; Pflueger, Solveig M V (2002. ) Expression of estrogen receptor beta in the fetal, neonatal, and prepubertal human prostate.The Prostate, , 52 (1 ) ,69-81 More Information
Lee, T M; Ho, S M; Tsang, L Y; Yang, S H; Li, L S; Chan, C C; Yang, S Y (2001. ) Effect on human attention of exposure to the electromagnetic field emitted by mobile phones. Neuroreport, , 12 (4 ) ,729-31
Lau, K M; LaSpina, M; Long, J; Ho, S M (2000. ) Expression of estrogen receptor (ER)-alpha and ER-beta in normal and malignant prostatic epithelial cells: regulation by methylation and involvement in growth regulation. Cancer research, , 60 (12 ) ,3175-82
Lee, K F; Lau, K M; Ho, S M (1999. ) Effects of cadmium on metallothionein-I and metallothionein-II mRNA expression in rat ventral, lateral, and dorsal prostatic lobes: quantification by competitive RT-PCR.Toxicology and applied pharmacology, , 154 (1 ) ,20-7 More Information
Kaplan, P J; Leav, I; Greenwood, J; Kwan, P W; Ho, S M (1996. ) Involvement of transforming growth factor alpha (TGFalpha) and epidermal growth factor receptor (EGFR) in sex hormone-induced prostatic dysplasia and the growth of an androgen-independent transplantable carcinoma of the prostate. Carcinogenesis, , 17 (12 ) ,2571-9
Ghatak, S; Oliveria, P; Kaplan, P; Ho, S M (1996. ) Expression and regulation of metallothionein mRNA levels in the prostates of noble rats: lack of expression in the ventral prostate and regulation by sex hormones in the dorsolateral prostate.The Prostate, , 29 (2 ) ,91-100 More Information
Ho, S M; Roy, D (1994. ) Sex hormone-induced nuclear DNA damage and lipid peroxidation in the dorsolateral prostates of Noble rats. Cancer letters, , 84 (2 ) ,155-62
Yu, M; Cates, J; Leav, I; Ho, S M (1989. ) Heterogeneity of [3H]estradiol binding sites in the rat prostate: properties and distribution of type I and type II sites. Journal of steroid biochemistry, , 33 (3 ) ,449-57
Ho, S M; Callard, I P (1984. ) High affinity binding of [3H]R5020 and [3H]progesterone by putative progesterone receptors in cytosol and nuclear extract of turtle oviduct.Endocrinology, , 114 (1 ) ,70-9 More Information
Mak, P; Ho, S M; Callard, I P (1982. ) Estrogen receptors in the turtle brain. Brain research, , 231 (1 ) ,63-74
Gapp, D A; Ho, S M; Callard, I P (1979. ) Plasma levels of vitellogenin in Chrysemys picta during the annual gonadal cycle: measurement by specific radioimmunoassay.Endocrinology, , 104 (3 ) ,784-90 More Information
Schade, George R; Holt, Sarah; Zhang, Xiaotun; Song, Dan; Wright, Jonathan L; Zhao, Shanshan; Kolb, Suzanne; Lam, Hung-Ming; Levin, Linda; Leung, Yuet-Kin; Ho, Shuk-Mei; Stanford, Janet L (2016. ) Prostate Cancer Expression Profiles of Cytoplasmic ER?1 and Nuclear ER?2 Are Associated with Poor Outcomes following Radical Prostatectomy.The Journal of urology, , More Information
Paquette, Ian M; Ying, Jun; Shah, Shimul A; Abbott, Daniel E; Ho, Shuk-Mei (2015. ) African Americans should be screened at an earlier age for colorectal cancer.Gastrointestinal endoscopy, , 82 (5 ) ,878-83 More Information
Warzak, Denise A; Johnson, Sarah A; Ellersieck, Mark R; Roberts, R Michael; Zhang, Xiang; Ho, Shuk-Mei; Rosenfeld, Cheryl S (2015. ) Effects of post-weaning diet on metabolic parameters and DNA methylation status of the cryptic promoter in the A(vy) allele of viable yellow mice.The Journal of nutritional biochemistry, , 26 (6 ) ,667-74 More Information
Knower, Kevin C; To, Sarah Q; Leung, Yuet-Kin; Ho, Shuk-Mei; Clyne, Colin D (2014. ) Endocrine disruption of the epigenome: a breast cancer link.Endocrine-related cancer, , 21 (2 ) ,T33-55 More Information
Smithrud, David B; Wang, Xiaoyang; Tarapore, Pheruza; Ho, Shuk-Mei (2013. ) Crown Ether Host-Rotaxanes as Cytotoxic Agents.ACS medicinal chemistry letters, , 4 (1 ) ,27-31 More Information
Bakshi, Shlomo; Zhang, Xiang; Godoy-Tundidor, Sonia; Cheng, Robert Yuk Sing; Sartor, Maureen A; Medvedovic, Mario; Ho, Shuk-Mei (2008. ) Transcriptome analyses in normal prostate epithelial cells exposed to low-dose cadmium: oncogenic and immunomodulations involving the action of tumor necrosis factor.Environmental health perspectives, , 116 (6 ) ,769-76 More Information
Miller, Rachel L; Ho, Shuk-Mei (2008. ) Environmental epigenetics and asthma: current concepts and call for studies.American journal of respiratory and critical care medicine, , 177 (6 ) ,567-73 More Information
Tang, Wan-yee; Ho, Shuk-mei (2007. ) Epigenetic reprogramming and imprinting in origins of disease.Reviews in endocrine & metabolic disorders, , 8 (2 ) ,173-82 More Information
Zielie, P J; Mobley, J A; Ebb, R G; Jiang, Z; Blute, R D; Ho, S M (2004. ) A novel diagnostic test for prostate cancer emerges from the determination of alpha-methylacyl-coenzyme a racemase in prostatic secretions.The Journal of urology, , 172 (3 ) ,1130-3 More Information
Mobley, J A; Lam, Y W; Lau, K M; Pais, V M; L'Esperance, J O; Steadman, B; Fuster, L M Burgos; Blute, R D; Taplin, M E; Ho, S M (2004. ) Monitoring the serological proteome: the latest modality in prostate cancer detection.The Journal of urology, , 172 (1 ) ,331-7 More Information
Ho, Shuk-Mei (2004. ) Estrogens and anti-estrogens: key mediators of prostate carcinogenesis and new therapeutic candidates.Journal of cellular biochemistry, , 91 (3 ) ,491-503 More Information
Pais, Vernon; Leav, Irwin; Lau, Kin-Mang; Jiang, Zhong; Ho, Shuk-Mei (2003. ) Estrogen receptor-beta expression in human testicular germ cell tumors. Clinical cancer research : an official journal of the American Association for Cancer Research, , 9 (12 ) ,4475-82
Kwong, Joseph; Lui, K; Chan, Peter S F; Ho, Shuk-Mei; Wong, Y C; Xuan, J W; Chan, Franky L (2003. ) Expression study of three secretory proteins (prostatic secretory protein of 94 amino acids, probasin, and seminal vesicle secretion II) in dysplastic and neoplastic rat prostates.The Prostate, , 56 (2 ) ,81-97 More Information
Melnick, Ronald; Lucier, George; Wolfe, Mary; Hall, Roxanne; Stancel, George; Prins, Gail; Gallo, Michael; Reuhl, Kenneth; Ho, Shuk-Mei; Brown, Terry; Moore, John; Leakey, Julian; Haseman, Joseph; Kohn, Michael (2002. ) Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer review. Environmental health perspectives, , 110 (4 ) ,427-31
Tekur, Seshadri; Ho, Shuk-Mei (2002. ) Ribozyme-mediated downregulation of human metallothionein II(a) induces apoptosis in human prostate and ovarian cancer cell lines. Molecular carcinogenesis, , 33 (1 ) ,44-55
Taplin, M E; Ho, S M (2001. ) Clinical review 134: The endocrinology of prostate cancer.The Journal of clinical endocrinology and metabolism, , 86 (8 ) ,3467-77 More Information
Lee, K F; Lau, K M; Ho, S M (1999. ) Generation and characterization of hammerhead ribozymes targeting rodent metallothionein-I and -II ribonucleic acid.Toxicology and applied pharmacology, , 161 (3 ) ,294-301 More Information
Walker, C; Ahmed, S A; Brown, T; Ho, S M; Hodges, L; Lucier, G; Russo, J; Weigel, N; Weise, T; Vandenbergh, J (1999. ) Species, interindividual, and tissue specificity in endocrine signaling. Environmental health perspectives, , 107 Suppl 4 ,619-24
Lane, K E; Leav, I; Ziar, J; Bridges, R S; Rand, W M; Ho, S M (1997. ) Suppression of testosterone and estradiol-17beta-induced dysplasia in the dorsolateral prostate of Noble rats by bromocriptine. Carcinogenesis, , 18 (8 ) ,1505-10
Ho, S M; Leav, I; Merk, F B; Yu, M; Kwan, P W; Ziar, J (1995. ) Induction of atypical hyperplasia, apoptosis, and type II estrogen-binding sites in the ventral prostates of Noble rats treated with testosterone and pharmacologic doses of estradiol-17 beta. Laboratory investigation; a journal of technical methods and pathology, , 73 (3 ) ,356-65
Ho, S M; Yu, M (1995. ) Hormonal regulation of nuclear type II estrogen binding sites in the dorsolateral prostate of noble rats. The Journal of steroid biochemistry and molecular biology, , 52 (3 ) ,233-8
Leav, I; Kwan, P W; Merk, F B; Chang, C; Ho, S M (1992. ) Immunohistochemical and in situ hybridization studies of androgen receptor expression in a transplantable androgen-independent prostatic carcinoma line (AIT) of Noble rats. Laboratory investigation; a journal of technical methods and pathology, , 67 (6 ) ,788-95
Ho, S M; Press, D; Liang, L C; Sower, S (1987. ) Identification of an estrogen receptor in the testis of the sea lamprey, Petromyzon marinus. General and comparative endocrinology, , 67 (1 ) ,119-25
Wang, Quan; Trevino, Lindsey S; Lee Yean Wong, Rebecca; Medvedovic, Mario; Chen, Jing; Ho, Shuk-Mei; Shen, Jianjun; Foulds, Charles E; Coarfa, Cristian; O'Malley, Bert W; Shilatifard, Ali; Walker, Cheryl L (2016. ) Reprogramming of the Epigenome by MLL1 Links Early-life Environmental Exposures to Prostate Cancer Risk.Molecular endocrinology (Baltimore, Md.), , me20151310 More Information
Miller M, Bailey B, Govindarajah V, Levin L, Metzger T, Pinney SM, Leung YK, Ho SM. (2016. ) A community survey on knowledge of the impact of environmental and epigenetic factors on health and disease. Perspectives in Public Health, , March ,
Ho SM, Cheong A, To S, Janakiram V, Tarapore P, Leung YK. (2016. ) Cancer and Developmental Origins of Health and Disease.315-336 More Information
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Academic - shukmeiho@uams.edu