Shouxiong Huang

Shouxiong Huang

Assistant Professor

Kettering Lab Complex

251

COM EH EGMT Huang Lab - 0056

Kettering Lab
251 Kettering Laboratory Complex
Cincinnati, Ohio 45267

Professional Summary

I use multidisciplinary approaches in immunology and metabolomics to
study the natural (bacterial) products for T cell activation and environmental pollutants for immune dysregulation. Current research focuses on determining (i) the structures and functions of mycobacterial metabolites to activate mucosal-associated invariant T (MAIT) cells in human tuberculosis, and (ii) the impact of air pollutants on T cell activation and lipid metabolism to exacerbate pregnancy disorders.

Education

PhD, The Ohio State University. Columbus, Wooster, OH, 2003 (Veterinary Preventive Medicine, Molecular Microbiology.)

Bachelor of Chinese Medicine, Beijing University of Chinese Medicine and Pharmacy, Beijing, China,, 1993 (Biomedical Sciences, Chinese Medicine Basics, Immunopharmacology of Natural Products)

Research Support

Grant: #R21 AI115358 Investigators:Huang, Shouxiong 12-01-2014 -11-30-2017 National Institute of Allergy and Infectious Diseases, Antigen metabolomics for mucosal-associated invariant T cells in tuberculosis Role:PI $277,011.00

Grant: #URC Faculty Research Grants for 2013-2014 Investigators:Huang, Shouxiong 01-23-2014 -01-22-2015 UC URC Faculty Research Grants for 2013-2014 Role:PI $6,500.00 Completed

Grant: #IA-629987 Investigators:Huang, Shouxiong 07-01-2019 -06-30-2020 American Lung Association Purification and identification of mycobacterial metabolites to activate mucosal-associated invariant T cells Role:PI $75,000.00 Awarded Level:Private Non-Profit

Publications

Peer Reviewed Publications

Huang, Shouxiong*; Sharma, Manju; Zhang, Shuangmin; Niu, Liang; Zhang, Xiang (2018. )Innate-like activation of mucosal-associated invariant T cells in mycobacterial infection (abstract) .Journal of Immunology, ,200 (1 ),(http://www.jimmunol.org/content/200/1_Supplement/114.12) *Corresponding author

Sharma, Manju; Zhang, Xiang; Huang Shouxiong* (2018. )Integrate Imaging Flow Cytometry and Transcriptomic Profiling to Evaluate Altered Endocytic CD1d Trafficking .Journal of visual experiment, ,(https://www.jove.com/video/57528/)*Corresponding author ,

Li, Tao; Hu, Rong; Chen, Zi; Li, Qiyuan; Huang, Shouxiong; Zhu, Zhou; Zhou, Lin-Fu (2018. )Fine particulate matter (PM2.5): The culprit for chronic lung diseases in China.Chronic diseases and translational medicine, ,4 (3 ),176-186

Kim, Dasom; Chen, Zi; Zhou, Lin-Fu; Huang, Shou-Xiong* (2018. )Air pollutants and early origins of respiratory diseases.Chronic diseases and translational medicine, ,4 (2 ),75-94

Langevin, Scott; Kuhnell, Damaris; Parry, Tess; Biesiada, Jacek; Huang, Shouxiong; Wise-Draper, Trisha; Casper, Keith; Zhang, Xiang; Medvedovic, Mario; Kasper, Susan (2017. )Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cells in vitro reveals common secretion profiles and potential utility as salivary biomarkers.Oncotarget, ,8 (47 ),82459-82474

Sharma, Manju; Zhang, Xiang; Zhang, Shuangmin; Niu, Liang; Ho, Shuk-Mei; Chen, Aimin; Huang, Shouxiong* (2017. )Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants.Scientific reports, ,7 (1 ),2085

Huang, Shouxiong* (2016. )Targeting Innate-Like T Cells in Tuberculosis.Frontiers in immunology, ,7 ,594

Van Rhijn, Ildiko; van Berlo, Twan; Hilmenyuk, Tamara; Cheng, Tan-Yun; Wolf, Benjamin J; Tatituri, Raju V V; Uldrich, Adam P; Napolitani, Giorgio; Cerundolo, Vincenzo; Altman, John D; Willemsen, Peter; Huang, Shouxiong; Rossjohn, Jamie; Besra, Gurdyal S; Brenner, Michael B; Godfrey, Dale I; Moody, D Branch (2016. )Human autoreactive T cells recognize CD1b and phospholipids.Proceedings of the National Academy of Sciences of the United States of America, ,113 (2 ),380-5

Huang, Shouxiong*; Moody, D Branch* (2016. )Donor-unrestricted T cells in the human CD1 system .Immunogenetics, ,68 (8 ),577-96 *corresponding authors

Wang, Yunan; Kayoumu, Abudurexiti; Lu, Guotao; Xu, Pengfei; Qiu, Xu; Chen, Liye; Qi, Rong; Huang, Shouxiong; Li, Weiqin; Wang, Yuhui; Liu, George (2016. )Experimental Models in Syrian Golden Hamster Replicate Human Acute Pancreatitis.Scientific reports, ,6 ,28014

de Jong, Annemieke; Cheng, Tan-Yun; Huang, Shouxiong; Gras, Stephanie; Birkinshaw, Richard W; Kasmar, Anne G; Van Rhijn, Ildiko; Peña-Cruz, Victor; Ruan, Daniel T; Altman, John D; Rossjohn, Jamie; Moody, D Branch (2014. )CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens.Nature immunology, ,15 (2 ),177-85

Ly, Dalam; Kasmar, Anne G; Cheng, Tan-Yun; de Jong, Annemieke; Huang, Shouxiong; Roy, Sobhan; Bhatt, Apoorva; van Summeren, Ruben P; Altman, John D; Jacobs, William R; Adams, Erin J; Minnaard, Adriaan J; Porcelli, Steven A; Moody, D Branch (2013. )CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens.The Journal of experimental medicine, ,210 (4 ),729-41

Young, Mary H; U (2013. )MAIT cell recognition of MR1 on bacterially infected and uninfected cells.PloS one, ,8 (1 ),e53789

Huang, Shouxiong; Cheng, Tan-Yun; Young, David C; Layre, Emilie; Madigan, Cressida A; Shires, John; Cerundolo, Vincenzo; Altman, John D; Moody, D Branch (2011. )Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system.Proceedings of the National Academy of Sciences of the United States of America, ,108 (48 ),19335-40

Chua, Wei-Jen; Kim, Sojung; Myers, Nancy; Huang, Shouxiong; Yu, Lawrence; Fremont, Daved H; Diamond, Michael S; Hansen, Ted H (2011. )Endogenous MHC-related protein 1 is transiently expressed on the plasma membrane in a conformation that activates mucosal-associated invariant T cells.Journal of immunology, ,186 (8 ),4744-50

Le Bourhis, Lionel; Martin, Emmanuel; Péguillet, Isabelle; Guihot, Amélie; Froux, Nathalie; Coré, Maxime; Lévy, Eva; Dusseaux, Mathilde; Meyssonnier, Vanina; Premel, Virginie; Ngo, Charlotte; Riteau, Béatrice; Duban, Livine; Robert, Delphine; Huang, Shouxiong; Rottman, Martin; Soudais, Claire; Lantz, Olivier (2010. )Antimicrobial activity of mucosal-associated invariant T cells.Nature immunology, ,11 (8 ),701-8

Huang, Shouxiong; Martin, Emmanuel; Kim, Sojung; Yu, Lawrence; Soudais, Claire; Fremont, Daved H; Lantz, Olivier; Hansen, Ted H (2009. )MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution.Proceedings of the National Academy of Sciences of the United States of America, ,106 (20 ),8290-5

Huang, Shouxiong; Gilfillan, Susan; Kim, Sojung; Thompson, Bruce; Wang, Xiaoli; Sant, Andrea J; Fremont, Daved H; Lantz, Olivier; Hansen, Ted H (2008. )MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells.The Journal of experimental medicine, ,205 (5 ),1201-11

Huang, Shouxiong; Sahin, Orhan; Zhang, Qijing (2007. )Infection-induced antibodies against the major outer membrane protein of Campylobacter jejuni mainly recognize conformational epitopes.FEMS microbiology letters, ,272 (2 ),137-43

Hansen, Ted H; Huang, Shouxiong; Arnold, Phoebe L; Fremont, Daved H (2007. )Patterns of nonclassical MHC antigen presentation.Nature immunology, ,8 (6 ),563-8

Luangtongkum, Taradon; Morishita, Teresa Y; Ison, Aaron J; Huang, Shouxiong; McDermott, Patrick F; Zhang, Qijing (2006. )Effect of conventional and organic production practices on the prevalence and antimicrobial resistance of Campylobacter spp. in poultry.Applied and environmental microbiology, ,72 (5 ),3600-7

Huang, Shouxiong; Gilfillan, Susan; Cella, Marina; Miley, Michael J; Lantz, Olivier; Lybarger, Lonnie; Fremont, Daved H; Hansen, Ted H (2005. )Evidence for MR1 antigen presentation to mucosal-associated invariant T cells.The Journal of biological chemistry, ,280 (22 ),21183-93

Huang, Shouxiong; Luangtongkum, Taradon; Morishita, Teresa Y; Zhang, Qijing (2005. )Molecular typing of Campylobacter strains using the cmp gene encoding the major outer membrane protein.Foodborne pathogens and disease, ,2 (1 ),12-23

Luo, Naidan; Pereira, Sonia; Sahin, Orhan; Lin, Jun; Huang, Shouxiong; Michel, Linda; Zhang, Qijing (2005. )Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressure.Proceedings of the National Academy of Sciences of the United States of America, ,102 (3 ),541-6

Sahin, Orhan; Luo, Naidan; Huang, Shouxiong; Zhang, Qijing (2003. )Effect of Campylobacter-specific maternal antibodies on Campylobacter jejuni colonization in young chickens .Applied and environmental microbiology, ,69 (9 ),5372-9

Lin, Jun; Huang, Shouxiong; Zhang, Qijing (2002. )Outer membrane proteins: key players for bacterial adaptation in host niches .Microbes and infection / Institut Pasteur, ,4 (3 ),325-31

Zhang, Q; Meitzler, J C; Huang, S; Morishita, T (2000. )Sequence polymorphism, predicted secondary structures, and surface-exposed conformational epitopes of Campylobacter major outer membrane protein .Infection and immunity, ,68 (10 ),5679-89

Positions and Work Experience

09-01-1993 -03-20-1999 Research Assistant, Lecturer,, Development of Human Dendritic Cells and Lymphocytes, Immunopharmacology of Natural Products, Immunopathology of Gut Inflammation, Fujian Institute of Chinese Medicine and Pharmacy,, 252 WuSi Road, Fuzhou, Fujian, China

08-01-2013 - Assistant Professor,, Immunology and metabolomics, natural (bacterial) products for T cell activation, and environmental pollutants for immune dysregulation., Department of Environmental Health, University of Cincinnati College of Medicine,, 160 Panzeca Way, Cincinnati, OH 45249

Post Graduate Training and Education

04-21-2003-07-20-2009 Postdoctoral Research Fellow, T cell biology, antigen presentation, mucosal-associated invariant T (MAIT) cells, Department of Pathology and Immunology, Washington University School of Medicine, ,Clinical Science Research Building, 4939 Children’s Place, St. Louis, MO 63110

07-21-2009-12-31-2011 Postdoctoral Research Fellow, T cell biology, Lipid antigen presentation, Lipidomics in immunology, Immunity against mycobacterial infection, Division of Rheumatology, Immunology, and Allergy, ,514 Smith Building, 1 Jimmy Fund Way, Boston, 02115

01-01-2012-06-02-2013 Instructor in Medicine, T cell biology, Lipid antigen presentation, Lipidomics in immunology, Immunity against mycobacterial infection, Division of Rheumatology, Immunology, and Allergy , ,514 Smith Building, 1 Jimmy Fund Way, Boston, 02115

Contact Information

Academic - Kettering Lab
251 Kettering Laboratory Complex
Cincinnati  Ohio, 45267
Phone: 513-558-7572
Fax: 513-558-1026
shouxiong.huang@uc.edu