Shouxiong Huang

Shouxiong Huang , PhD

Assistant Professor

Kettering Lab
251 Kettering Laboratory Complex
160 Panzeca Way
Cincinnati, Ohio 45267
Phone 513-558-7572
Fax 513-558-1026
Email shouxiong.huang@uc.edu

Professional Summary

I use multidisciplinary immunology and chemical biology approaches to
study natural products for T cell activation in diseases and immune dysregulation in environmental exposure. Current research focuses on determining (i) the structures and functions of mycobacterial metabolites to activate mucosal-associated invariant T (MAIT) cells in human tuberculosis, and (ii) the impact of air pollutants on T cell immunity and lipid metabolism to exacerbate infections and inflammations.

Education

Bachelor of Medicine: Beijing University of Traditional Chinese Medicine Beijing, China, 1993 (Basic Sciences of Traditional Medicine, Immunopharmacology of Natural Products)

Doctoral Degree: The Ohio State University. Columbus, OH, 2003 (Veterinary Preventive Medicine, Molecular Microbiology.)

Positions and Work Experience

1993 -1999 Research Assistant, Lecturer,, Human Lymphocyte Development, Natural Products in Immune Regulation, and Gut Inflammation, Fujian Institute of Chinese Medicine and Pharmacy,, 252 WuSi Road, Fuzhou, Fujian, China

2013 - Assistant Professor,, Immunology, Chemical biology, and Immunotoxicology. , Department of Environmental Health, University of Cincinnati College of Medicine,, 160 Panzeca Way, Cincinnati, OH 45249

2003 -2009 Postdoctoral Research Fellow, T cell biology, antigen presentation, mucosal-associated invariant T (MAIT) cells, Washington University School of Medicine,

2009 -2011 Postdoctoral Research Fellow, Antigen presentation, T cell biology, and Lipidomics, Brigham and Women's Hospital, Harvard Medical School,

2012 -2013 Instructor of Medicine, Antigen presentation, T cell biology, and Lipidomics, Brigham and Women's Hospital, Harvard Medical School,

Research Support

Grant: #R21 AI115358 Investigators:Huang, Shouxiong 12-01-2014 -11-30-2017 National Institute of Allergy and Infectious Diseases, Antigen metabolomics for mucosal-associated invariant T cells in tuberculosis Role:PI $277,011.00

Grant: #URC Faculty Research Grants for 2013-2014 Investigators:Huang, Shouxiong 01-23-2014 -01-22-2015 UC URC Faculty Research Grants for 2013-2014 Role:PI $6,500.00 Completed

Grant: #IA-629987 Investigators:Huang, Shouxiong 07-01-2019 -06-30-2020 American Lung Association Purification and identification of mycobacterial metabolites to activate mucosal-associated invariant T cells Role:PI $75,000.00 Awarded Level:Private Non-Profit

Publications

Peer Reviewed Publications

Manju Sharma, Shuangmin Zhang, Liang Niu, David Lewinsohn, Xiang Zhang and Shouxiong Huang* (2020. ) Mucosal-associated invariant T cells develop an innate-like transcriptomic program in anti-mycobacterial responses .Frontiers in Immunology, , 11 ,1136. https://doi.org/10.3389/fimmu.2020.01136. *corresponding author

Shouxiong Huang*, Quan He, Lin-Fu Zhou* (2020. ) T cell responses in respiratory viral infections and chronic obstructive pulmonary disease .Chinese Medical Journal , , 2021; 134(13): 1522-1534. doi: 10.1097/CM9.0000000000001388 ,*corresponding author

Shouxiong Huang*, Ming Tan (2020. ) HLA class I genotypes customize vaccination strategies in immune simulation to combat COVID-19 .bioRxiv. , , https://www.biorxiv.org/content/10.1101/2020.11.18.388983v1 ,*corresponding author

Sharma, Manju; Zhang, Xiang; Huang Shouxiong* (2018. ) Integrate Imaging Flow Cytometry and Transcriptomic Profiling to Evaluate Altered Endocytic CD1d Trafficking .Journal of visual experiment, , (https://www.jove.com/video/57528/)*Corresponding author ,

Kim, Dasom; Chen, Zi; Zhou, Lin-Fu; Huang, Shou-Xiong* (2018. ) Air pollutants and early origins of respiratory diseases.Chronic diseases and translational medicine, , 4 (2 ) ,75-94 More Information

Sharma, Manju; Zhang, Xiang; Zhang, Shuangmin; Niu, Liang; Ho, Shuk-Mei; Chen, Aimin; Huang, Shouxiong* (2017. ) Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants.Scientific reports, , 7 (1 ) ,2085 More Information

Huang, Shouxiong* (2016. ) Targeting Innate-Like T Cells in Tuberculosis.Frontiers in immunology, , 7 ,594 More Information

Van Rhijn, Ildiko; van Berlo, Twan; Hilmenyuk, Tamara; Cheng, Tan-Yun; Wolf, Benjamin J; Tatituri, Raju V V; Uldrich, Adam P; Napolitani, Giorgio; Cerundolo, Vincenzo; Altman, John D; Willemsen, Peter; Huang, Shouxiong; Rossjohn, Jamie; Besra, Gurdyal S; Brenner, Michael B; Godfrey, Dale I; Moody, D Branch (2016. ) Human autoreactive T cells recognize CD1b and phospholipids.Proceedings of the National Academy of Sciences of the United States of America, , 113 (2 ) ,380-5 More Information

Huang, Shouxiong*; Moody, D Branch* (2016. ) Donor-unrestricted T cells in the human CD1 system .Immunogenetics, , 68 (8 ) ,577-96 *corresponding authors

de Jong, Annemieke; Cheng, Tan-Yun; Huang, Shouxiong; Gras, Stephanie; Birkinshaw, Richard W; Kasmar, Anne G; Van Rhijn, Ildiko; Peña-Cruz, Victor; Ruan, Daniel T; Altman, John D; Rossjohn, Jamie; Moody, D Branch (2014. ) CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens.Nature immunology, , 15 (2 ) ,177-85 More Information

Ly, Dalam; Kasmar, Anne G; Cheng, Tan-Yun; de Jong, Annemieke; Huang, Shouxiong; Roy, Sobhan; Bhatt, Apoorva; van Summeren, Ruben P; Altman, John D; Jacobs, William R; Adams, Erin J; Minnaard, Adriaan J; Porcelli, Steven A; Moody, D Branch (2013. ) CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens.The Journal of experimental medicine, , 210 (4 ) ,729-41 More Information

Young, Mary H; U (2013. ) MAIT cell recognition of MR1 on bacterially infected and uninfected cells.PloS one, , 8 (1 ) ,e53789 More Information

Huang, Shouxiong; Cheng, Tan-Yun; Young, David C; Layre, Emilie; Madigan, Cressida A; Shires, John; Cerundolo, Vincenzo; Altman, John D; Moody, D Branch (2011. ) Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system.Proceedings of the National Academy of Sciences of the United States of America, , 108 (48 ) ,19335-40 More Information

Chua, Wei-Jen; Kim, Sojung; Myers, Nancy; Huang, Shouxiong; Yu, Lawrence; Fremont, Daved H; Diamond, Michael S; Hansen, Ted H (2011. ) Endogenous MHC-related protein 1 is transiently expressed on the plasma membrane in a conformation that activates mucosal-associated invariant T cells.Journal of immunology, , 186 (8 ) ,4744-50 More Information

Le Bourhis, Lionel; Martin, Emmanuel; Péguillet, Isabelle; Guihot, Amélie; Froux, Nathalie; Coré, Maxime; Lévy, Eva; Dusseaux, Mathilde; Meyssonnier, Vanina; Premel, Virginie; Ngo, Charlotte; Riteau, Béatrice; Duban, Livine; Robert, Delphine; Huang, Shouxiong; Rottman, Martin; Soudais, Claire; Lantz, Olivier (2010. ) Antimicrobial activity of mucosal-associated invariant T cells.Nature immunology, , 11 (8 ) ,701-8 More Information

Huang, Shouxiong; Martin, Emmanuel; Kim, Sojung; Yu, Lawrence; Soudais, Claire; Fremont, Daved H; Lantz, Olivier; Hansen, Ted H (2009. ) MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution.Proceedings of the National Academy of Sciences of the United States of America, , 106 (20 ) ,8290-5 More Information

Huang, Shouxiong; Gilfillan, Susan; Kim, Sojung; Thompson, Bruce; Wang, Xiaoli; Sant, Andrea J; Fremont, Daved H; Lantz, Olivier; Hansen, Ted H (2008. ) MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells.The Journal of experimental medicine, , 205 (5 ) ,1201-11 More Information

Huang, Shouxiong; Sahin, Orhan; Zhang, Qijing (2007. ) Infection-induced antibodies against the major outer membrane protein of Campylobacter jejuni mainly recognize conformational epitopes.FEMS microbiology letters, , 272 (2 ) ,137-43 More Information

Hansen, Ted H; Huang, Shouxiong; Arnold, Phoebe L; Fremont, Daved H (2007. ) Patterns of nonclassical MHC antigen presentation.Nature immunology, , 8 (6 ) ,563-8 More Information

Huang, Shouxiong; Gilfillan, Susan; Cella, Marina; Miley, Michael J; Lantz, Olivier; Lybarger, Lonnie; Fremont, Daved H; Hansen, Ted H (2005. ) Evidence for MR1 antigen presentation to mucosal-associated invariant T cells.The Journal of biological chemistry, , 280 (22 ) ,21183-93 More Information

Huang, Shouxiong; Luangtongkum, Taradon; Morishita, Teresa Y; Zhang, Qijing (2005. ) Molecular typing of Campylobacter strains using the cmp gene encoding the major outer membrane protein.Foodborne pathogens and disease, , 2 (1 ) ,12-23 More Information

Luo, Naidan; Pereira, Sonia; Sahin, Orhan; Lin, Jun; Huang, Shouxiong; Michel, Linda; Zhang, Qijing (2005. ) Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressure.Proceedings of the National Academy of Sciences of the United States of America, , 102 (3 ) ,541-6 More Information

Sahin, Orhan; Luo, Naidan; Huang, Shouxiong; Zhang, Qijing (2003. ) Effect of Campylobacter-specific maternal antibodies on Campylobacter jejuni colonization in young chickens .Applied and environmental microbiology, , 69 (9 ) ,5372-9

Lin, Jun; Huang, Shouxiong; Zhang, Qijing (2002. ) Outer membrane proteins: key players for bacterial adaptation in host niches .Microbes and infection / Institut Pasteur, , 4 (3 ) ,325-31

Zhang, Q; Meitzler, J C; Huang, S; Morishita, T (2000. ) Sequence polymorphism, predicted secondary structures, and surface-exposed conformational epitopes of Campylobacter major outer membrane protein .Infection and immunity, , 68 (10 ) ,5679-89

Post Graduate Training and Education

2003-2009 Postdoctoral Research Fellow, T cell biology, antigen presentation, mucosal-associated invariant T (MAIT) cells, Washington University School of Medicine, ,

2009-2011 Postdoctoral Research Fellow, Antigen presentation, T cell biology, and Lipidomics, Brigham and Women's Hospital, Harvard Medical School, ,

2012-2013 Instructor of Medicine, Antigen presentation, T cell biology, and Lipidomics, Brigham and Women's Hospital, Harvard Medical School Boston, ,

Contact Information

Academic - Kettering Lab
251 Kettering Laboratory Complex
Cincinnati  Ohio, 45267
Phone: 513-558-7572
Fax: 513-558-1026
shouxiong.huang@uc.edu