Kristin Hudock , MD,MSTR

Interests: cystic fibrosis, ARDS, neutrophil biology, poikiloderma with neutropenia 

BA: Mount Holyoke College 1997 (Biochemistry/French)

MD: Georgetown University School of Medicine 2003 (Medicine)

MSTR: University of Pennsylvania 2013 (Master of Science in Translational Research )

Residency: Georgetown University Hospital 2006 (Internal Medicine)

Fellowship: University of Pennsylvania 2011 (Pulmonary and Critical Care )

American Board of Internal Medicine (Pulmonary Disease) (Certification Date: 10-26-2009 ) - (Recertification Date: to 12-05-2021 )

American Board of Internal Medicine (Critical Care Medicine) (Certification Date: 11-14-2012 ) - (Recertification Date: to 01-01-2024 )

Critical Care Medicine

Lung Disease

Pulmonary Disease

Carbon Monoxide Poisoning

Chronic Cough

Dyspnea

Histoplasmosis

Legionnaires' Disease (Legionellosis)

Pleurisy

Pneumonia

Pulmonary Edema

Respiration Disorders

Respiratory Insufficiency

Respiratory Syncytial Virus (RSV)

Respiratory Tract Disease

Respiratory Tract Infections

Severe Acute Respiratory Syndrome (SARS)

Shortness of Breath

Sin Nombre Virus Infection (Hantavirus pulmonary syndrome)

Thoracic Disease

Tuberculosis

Whooping Cough (Pertussis)

Critical Care Medicine

Internal Medicine

Grant: #PBF Fellowship Investigators:Hudock, Kristin 10-05-2015 -12-03-2017 Parker B. Francis Foundation Uncovering Mechanisms of Lung Injury in CF using iPSC-derived Neutrophils Role:PI $52,000.00 Active Type:Grant

Grant: #CT2 Scholar Award 04-01-2017 -03-31-2018 Center for Clinical & Translational Science & Training SEQing mechanisms for rare neutropenias: Deciphering the neutrophil transcriptome Role:PI $25,000 Active Type:Grant

Grant: #HUDOCK15I0 Investigators:Hudock, Kristin 10-01-2015 -09-30-2017 Cystic Fibrosis Foundation CF iPSC-derived neutrophil responses in lung injury Role:PI $54,000.00 Active

Grant: #K08 HL124191 Investigators:Hudock, Kristin 09-01-2017 -08-31-2022 National Heart, Lung and Blood Institute The NET effect: Human CF epithelial responses to NETosis Role:PI $169,312.00 Awarded Level:Federal

Grant: #507-SUB PETAL / U01 HL123023 Investigators:Branson, Richard; Hudock, Kristin; Lindsell, Christopher; Norton, David 06-17-2014 -04-30-2021 National Heart, Lung and Blood Institute Clinical Center for the NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL Network) Clinical Trials Network Role:PI $93,334.00 Active Level:Federal

Grant: #647-SUB ROSE / U01 HL123009 Investigators:Hudock, Kristin; Norton, David 11-17-2015 -04-30-2021 National Heart, Lung and Blood Institute Reevaluation of Systemic Early neuromuscular blockade (ROSE) Role:PI $66,525.84 Active Level:Federal

Grant: #825-SUB VIOLET / U01 HL123009 Investigators:Hudock, Kristin; Norton, David 02-01-2017 -04-30-2021 National Heart, Lung and Blood Institute PETAL Network: VIOLET - Vitamin D to Improve Outcomes by Leveraging Early Treatment Role:PI $54,314.98 Active Level:Federal

Grant: #994-SUB CLOVERS / U01HL123009 Investigators:Hudock, Kristin; McCormack, Francis 11-01-2017 -04-30-2021 National Heart, Lung and Blood Institute CLOVERS: Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis Role:PI $179,707.70 Active Level:Federal

Grant: #HUDOCK20A0-KB Investigators:Hudock, Kristin 09-01-2019 -08-31-2022 Cystic Fibrosis Foundation The NET effect: Human CF epithelial responses to NETosis Role:PI $50,000.00 Awarded Level:Private Non-Profit

Grant: #IHC CLOVER-STEM / R01HL144624 Investigators:Hudock, Kristin 06-10-2019 -05-31-2023 National Heart, Lung and Blood Institute Study of Treatment's Echocardigraphic Mechanisms (CLOVERS-STEM) Role:PI $35,366.17 Awarded Level:Federal

Grant: #12345 / NHLBI Investigators:Hite, Robert; Hudock, Kristin 04-20-2020 -04-19-2021 National Heart, Lung and Blood Institute ORCHID Role:Collaborator $75,047.65 Active Level:Federal

Grant: #CCL - D3U01HL123009 Investigators:Hudock, Kristin 04-24-2020 -04-23-2021 National Heart, Lung and Blood Institute RED CORAL Role:PI $15,222.00 Active Level:Federal

Grant: #NYU / 0T24HL156812 Investigators:Hudock, Kristin 05-01-2020 -04-30-2021 National Heart, Lung and Blood Institute ACTIV-4 Role:PI $197,199.99 Active Level:Federal

Grant: #CCL - U01HL123009 Investigators:Hudock, Kristin 10-01-2020 -09-30-2021 National Heart, Lung and Blood Institute Blue Coral Role:PI 22356.77 Hold Level:Federal

Investigators:Hudock, Kristin 07-01-2021 -06-30-2023 Cystic Fibrosis Foundation Catching NETs in CF airways: Neutrophil Extracellular Traps and Lung Function Role:PI 50000.00 Hold Level:Non Profit

Grant: #OT2HL156812 Investigators:Hudock, Kristin 03-01-2021 -05-31-2022 Vanderbilt University ACTIV-4D RAAS Role:PI 0.00 Hold Level:Higher Education

Grant: #ASTER U01HL123009 Investigators:Hite, Robert; Hudock, Kristin 08-01-2021 -10-31-2022 Cleveland Clinic ASTER Role:PI 117664.00 Hold Level:Non Profit

Grant: #VUMC 104682 / 1OT2HL156812-01 Investigators:Hudock, Kristin 07-01-2022 -12-31-2022 National Heart, Lung and Blood Institute PETAL ACTIV 4D RAAS Executive Committee NECTAR Role:PI 76482.00 Hold Level:Federal

Grant: #CCHMC tba /U01HL123009-07S1 Investigators:Fermann, Gregory; Hite, Robert; Hudock, Kristin 10-01-2021 -10-31-2022 National Heart, Lung and Blood Institute PETAL Core Admin Role:Collaborator 97221.00 Hold Level:Federal

Grant: #CCF tba/5U01HL123009-07 Investigators:Fermann, Gregory; Hite, Robert; Hudock, Kristin 11-01-2022 -12-31-2023 National Heart, Lung and Blood Institute PETAL Core Admin Role:Collaborator 44874.00 Hold Level:Federal

Grant: #VUMC 109518; 1OT2HL156812-01 Investigators:Hite, Robert; Hudock, Kristin -04-30-2023 National Heart, Lung and Blood Institute Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE): Trial 1 Shionogi Protease Inhibitor (S-217622) Role:Collaborator 0.00 Hold Level:Federal

Grant: #HUDOCK23G0 Investigators:Hudock, Kristin 07-01-2023 -06-30-2025 Cystic Fibrosis Foundation Impact of Alpha-1 Antitrypsin on NET-Driven Inflammation and Infection Role:PI 166326.00 Hold Level:Non Profit

Grant: #SED003 Investigators:Hudock, Kristin 06-29-2023 -06-28-2026 Sedana Medical AB INSPiRE-ICU1 Role:PI 0.00 Hold

Grant: #CTA - PREVENT Investigators:Hite, Robert; Hudock, Kristin; Ramser, Evan 11-01-2023 -04-30-2025 Department of the Army Medical Research Acquisition Activity PREVENT Role:Collaborator 87540.16 Hold Level:Federal

Grant: #005970P223 Investigators:Hudock, Kristin 07-01-2023 -06-30-2024 Cystic Fibrosis Foundation Impact of Alpha-1 Antitrypsin on NET-Driven Inflammation and Infection. Role:PI 125000.00 Hold Level:Non Profit

Grant: #DB-EF-PHASEIII-0001 Investigators:Hudock, Kristin 12-15-2023 -12-15-2026 Direct Biologics, Inc. Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles for Hospitalized Patients with Moderate-to-Severe ARDS: A Phase III Clinical Trial" (Protocol DB-EF-PHASEIII-0001) Role:PI 713351.35 Active Level:Industry

Grant: #Neutralize-AKI SCD-006 Investigators:Hudock, Kristin 05-16-2024 -05-15-2027 ICON Clinical Research, LLC A Multi-Center, Randomized, Controlled, Pivotal Study to Assess the Safety and Efficacy of a Selective Cytopheretic Device in Patients with Acute Kidney Injury Requiring Continuous Kidney Replacement Role:PI 478339.86 Hold Level:Industry

Grant: #1247928 Investigators:Hudock, Kristin 07-01-2024 -06-30-2026 Alpha-1 Foundation A Novel Therapeutic Strategy to Augment AAT in Murine Models of AATD. Role:PI 199000.00 Hold Level:Non Profit

Grant: #1UG3HL166785-01A1 / GRT65805 Investigators:Hite, Robert; Hudock, Kristin; Ramser, Evan -08-31-2030 National Heart, Lung and Blood Institute PREVENT-ViLi Role:Collaborator 0.00 Hold Level:Federal

Grant: #REP0321 Investigators:Hudock, Kristin 07-19-2024 -10-31-2024 IQVIA Clinical Trial Payments Reparixin 1200 mg three times a day as add-on therapy to standard of care to limit disease progression in hospitalised adult patients with COVID-19 other community-acquired pneumonia. A multinational, Role:PI 0.00 Hold Level:Industry

Grant: #R01HL170156 JIT-HOLD Investigators:Hudock, Kristin 01-01-2025 -12-31-2029 National Heart, Lung and Blood Institute The NET Impact on Lung Epithelia in Cystic Fibrosis and Mucoobstruction Role:PI 0.00 Hold Level:Federal

Grant: #UMich SUBK00022988 (U01HL168478) Investigators:Hite, Robert; Hudock, Kristin; Ramser, Evan 05-01-2024 -04-30-2028 National Heart, Lung and Blood Institute Coordination for ARDS, Pneumonia, and Sepsis supporting Training, Organization and Network Efficiency (CAPSTONE) Role:Collaborator 126969.75 Hold Level:Federal

Peer Reviewed Publications

Reilly, John P; Anderson, Brian J; Hudock, Kristin M; Dunn, Thomas G; Kazi, Altaf; Tommasini, Anna; Charles, Dudley; Shashaty, Michael G S; Mikkelsen, Mark E; Christie, Jason D; Meyer, Nuala J (2016. ) Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis.Critical care (London, England), , 20 (1 ) ,222 More Information

Mills, Jason A; Hudock, Kristin M; Sullivan, Spencer K; Herrera, Pamela; Sullivan, Lisa M; Gadue, Paul; French, Deborah L (2015. ) Generation of poikiloderma with neutropenia (PN) induced pluripotent stem cells (iPSCs).Stem cell research, , 15 (3 ) ,595-7 More Information

Shreenivas, Satya S; Lilly, Scott M; Szeto, Wilson Y; Desai, Nimesh; Anwaruddin, Saif; Bavaria, Joseph E; Hudock, Kristin M; Thourani, Vinod H; Makkar, Raj; Pichard, Augusto; Webb, John; Dewey, Todd; Kapadia, Samir; Suri, Rakesh M; Xu, Ke; Leon, Martin B; Herrmann, Howard C (2015. ) Cardiopulmonary bypass and intra-aortic balloon pump use is associated with higher short and long term mortality after transcatheter aortic valve replacement: a PARTNER trial substudy.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, , 86 (2 ) ,316-22 More Information

Paluru, Prasuna; Hudock, Kristin M; Cheng, Xin; Mills, Jason A; Ying, Lei; Galvão, Aline M; Lu, Lin; Tiyaboonchai, Amita; Sim, Xiuli; Sullivan, Spencer K; French, Deborah L; Gadue, Paul (2014. ) The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cells.Stem cell research, , 12 (2 ) ,441-51 More Information

Hudock, Kristin M; Liu, Yuhong; Mei, Junjie; Marino, Roberta C; Hale, Jason E; Dai, Ning; Worthen, G Scott (2012. ) Delayed resolution of lung inflammation in Il-1rn-/- mice reflects elevated IL-17A/granulocyte colony-stimulating factor expression.American journal of respiratory cell and molecular biology, , 47 (4 ) ,436-44 More Information

Mei, Junjie; Liu, Yuhong; Dai, Ning; Hoffmann, Christian; Hudock, Kristin M; Zhang, Peggy; Guttentag, Susan H; Kolls, Jay K; Oliver, Paula M; Bushman, Frederic D; Worthen, G Scott (2012. ) Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice.The Journal of clinical investigation, , 122 (3 ) ,974-86 More Information

Paris, Andrew J; Liu, Yuhong; Mei, Junjie; Dai, Ning; Guo, Lei; Spruce, Lynn A; Hudock, Kristin M; Brenner, Jacob S; Zacharias, William J; Mei, Hankun D; Slamowitz, April R; Bhamidipati, Kartik; Beers, Michael F; Seeholzer, Steven H; Morrisey, Edward E; Worthen, G Scott (2016. ) Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury.American journal of physiology. Lung cellular and molecular physiology, , 311 (6 ) ,L1062-L1075 More Information

Hudock, K M; Hafeez, A; Kaltenbach, J C (1997. ) Cell Localization of Lectin Binding in Microciona prolifera Sponge.The Biological bulletin, , 193 (2 ) ,241-242 More Information

Koo, C W; Gupta, N; Baliff, J P; Hudock, K; Haas, A R (2011. ) A tale of two sisters: biomass fuel exposure-related lung disease.Clinical radiology, , 66 (2 ) ,190-3 More Information

Kaltenbach JC, Hudock KM, Burger MM, Miseciv G, Kuhns WJ. (1996. ) Masking effects of sulfate upon Microciona sponge cell carbohydrates: A lectin histochemical study. .The Biological Bulletin, , 191 (2 ) ,296

Hudock, Kristin M; Clancy, John Paul (2017. ) An update on new and emerging therapies for cystic fibrosis.Expert opinion on emerging drugs, , 22 (4 ) ,331-346 More Information

Kaltenbach, J C; Hudock, K M; Burger, M M; Misevic, G; Kuhns, W J (1996. ) Masking Effects of Sulfate upon Microciona Sponge Cell Carbohydrates: A Lectin Histochemical Study.The Biological bulletin, , 191 (2 ) ,296-297 More Information

Kramer, Elizabeth L; Madala, Satish K; Hudock, Kristin M; Davidson, Cynthia; Clancy, John P (2020. ) Subacute TGF? Exposure Drives Airway Hyperresponsiveness in Cystic Fibrosis Mice through the PI3K Pathway.American journal of respiratory cell and molecular biology, , 62 (5 ) ,657-667 More Information

Hudock, Kristin M; Collins, Margaret S; Imbrogno, Michelle; Snowball, John; Kramer, Elizabeth L; Brewington, John J; Gollomp, Kandace; McCarthy, Cormac; Ostmann, Alicia J; Kopras, Elizabeth J; Davidson, Cynthia R; Srdiharan, Anusha; Arumugam, Paritha; Sengupta, Shaon; Xu, Yan; Worthen, G Scott; Trapnell, Bruce C; Clancy, John Paul (2020. ) Neutrophil extracellular traps activate IL-8 and IL-1 expression in human bronchial epithelia.American journal of physiology. Lung cellular and molecular physiology, , More Information

Gollomp, Kandace; Sarkar, Amrita; Harikumar, Sanjiv; Seeholzer, Steven H; Arepally, Gowthami M; Hudock, Kristin; Rauova, Lubica; Kowalska, M Anna; Poncz, Mortimer (2020. ) Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis.Blood, , 135 (10 ) ,743-754 More Information

, ; Ginde, Adit A; Brower, Roy G; Caterino, Jeffrey M; Finck, Lani; Banner-Goodspeed, Valerie M; Grissom, Colin K; Hayden, Douglas; Hough, Catherine L; Hyzy, Robert C; Khan, Akram; Levitt, Joseph E; Park, Pauline K; Ringwood, Nancy; Rivers, Emanuel P; Self, Wesley H; Shapiro, Nathan I; Thompson, B Taylor; Yealy, Donald M; Talmor, Daniel (2019. ) Early High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients.The New England journal of medicine, , 381 (26 ) ,2529-2540 More Information

, ; Moss, Marc; Huang, David T; Brower, Roy G; Ferguson, Niall D; Ginde, Adit A; Gong, M N; Grissom, Colin K; Gundel, Stephanie; Hayden, Douglas; Hite, R Duncan; Hou, Peter C; Hough, Catherine L; Iwashyna, Theodore J; Khan, Akram; Liu, Kathleen D; Talmor, Daniel; Thompson, B Taylor; Ulysse, Christine A; Yealy, Donald M; Angus, Derek C (2019. ) Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.The New England journal of medicine, , 380 (21 ) ,1997-2008 More Information

Hauschildt, Katrina E; Seigworth, Claire; Kamphuis, Lee A; Hough, Catherine L; Moss, Marc; McPeake, Joanne M; Iwashyna, Theodore J (2020. ) Financial Toxicity After Acute Respiratory Distress Syndrome: A National Qualitative Cohort Study.Critical care medicine, , 48 (8 ) ,1103-1110 More Information

Bonaventura, Aldo; Vecchié, Alessandra; Wang, Tisha S; Lee, Elinor; Cremer, Paul C; Carey, Brenna; Rajendram, Prabalini; Hudock, Kristin M; Korbee, Leslie; Van Tassell, Benjamin W; Dagna, Lorenzo; Abbate, Antonio (2020. ) Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies.Frontiers in immunology, , 11 ,1625 More Information

Other Publications

Hudock, KM. (2012. ) Air Embolism: Clinician Review .Decision Support in Medicine,

Hudock, KM. (2016. ) Air Embolism: Clinician Review .Decision Support in Medicine,

Book Chapter

Hudock, KM, Lanken, PN. (2013 ) Liberation and Weaning from Mechanical Ventilation and Extubation The Intensive Care Manual, 2nd Edition .

Academic - UC Department of Internal Medicine
Division of Pulmonary, Critical Care & Sleep Medicine
Cincinnati  Ohio, 45267-0564
Phone: 513-558-4831
Fax: 513-558-4858
Kristin.Hudock@cchmc.org

Research - CCHMC Division of Pulmonary Biology
R4027, CCHMC
Cincinnati  Ohio, 45229