Kristin Hudock

Kristin Hudock

Asst Professor - Clin Geo

Childrens Hospital Bldg R


COM IM Pulmonary Division - 0564

UC Department of Internal Medicine
Division of Pulmonary, Critical Care & Sleep Medicine
Cincinnati, Ohio 45267-0564

CCHMC Division of Pulmonary Biology
R4027, CCHMC
Cincinnati, Ohio 45229

Professional Summary

Interests: cystic fibrosis, ARDS, neutrophil biology, poikiloderma with neutropenia 


BA, Mount Holyoke College 1997 (Biochemistry/French)

MD, Georgetown University School of Medicine 2003 (Medicine)

MSTR, University of Pennsylvania 2013 (Master of Science in Translational Research )

Residency, Georgetown University Hospital 2006 (Internal Medicine)

Fellowship, University of Pennsylvania 2011 (Pulmonary and Critical Care )

UC Health Clinical Focus

Critical Care Medicine

Pulmonary Disease

UC Health Specialities

Critical Care Medicine

Internal Medicine

Research Support

Grant: #PBF Fellowship Investigators:Hudock, Kristin 10-05-2015 -12-03-2017 Parker B. Francis Foundation Uncovering Mechanisms of Lung Injury in CF using iPSC-derived Neutrophils Role:PI $52,000.00 Active Type:Grant

Grant: #CT2 Scholar Award 04-01-2017 -03-31-2018 Center for Clinical & Translational Science & Training SEQing mechanisms for rare neutropenias: Deciphering the neutrophil transcriptome Role:PI $25,000 Active Type:Grant

Grant: #HUDOCK15I0 Investigators:Hudock, Kristin 10-01-2015 -09-30-2017 Cystic Fibrosis Foundation CF iPSC-derived neutrophil responses in lung injury Role:PI $54,000.00 Active

Grant: #K08 HL124191 Investigators:Hudock, Kristin 09-01-2017 -08-31-2022 National Heart, Lung and Blood Institute The NET effect: Human CF epithelial responses to NETosis Role:PI $169,312.00 Awarded Level:Federal

Grant: #507-SUB PETAL / U01 HL123023 Investigators:Branson, Richard; Hudock, Kristin; Lindsell, Christopher; Norton, David 06-17-2014 -04-30-2021 National Heart, Lung and Blood Institute Clinical Center for the NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL Network) Clinical Trials Network Role:PI $93,334.00 Active Level:Federal

Grant: #647-SUB ROSE / U01 HL123009 Investigators:Hudock, Kristin; Norton, David 11-17-2015 -04-30-2021 National Heart, Lung and Blood Institute Reevaluation of Systemic Early neuromuscular blockade (ROSE) Role:PI $66,525.84 Active Level:Federal

Grant: #825-SUB VIOLET / U01 HL123009 Investigators:Hudock, Kristin; Norton, David 02-01-2017 -04-30-2021 National Heart, Lung and Blood Institute PETAL Network: VIOLET - Vitamin D to Improve Outcomes by Leveraging Early Treatment Role:PI $54,314.98 Active Level:Federal

Grant: #994-SUB CLOVERS / U01HL123009 Investigators:Hudock, Kristin; McCormack, Francis 11-01-2017 -04-30-2021 National Heart, Lung and Blood Institute CLOVERS: Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis Role:PI $179,707.70 Active Level:Federal

Grant: #HUDOCK20A0-KB Investigators:Hudock, Kristin 09-01-2019 -08-31-2022 Cystic Fibrosis Foundation The NET effect: Human CF epithelial responses to NETosis Role:PI $50,000.00 Awarded Level:Private Non-Profit

Grant: #IHC CLOVER-STEM / R01HL144624 Investigators:Hudock, Kristin 06-10-2019 -05-31-2023 National Heart, Lung and Blood Institute Study of Treatment's Echocardigraphic Mechanisms (CLOVERS-STEM) Role:PI $35,366.17 Awarded Level:Federal


Peer Reviewed Publications

Reilly, John P; Anderson, Brian J; Hudock, Kristin M; Dunn, Thomas G; Kazi, Altaf; Tommasini, Anna; Charles, Dudley; Shashaty, Michael G S; Mikkelsen, Mark E; Christie, Jason D; Meyer, Nuala J (2016. )Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis.Critical care (London, England), ,20 (1 ),222

Mills, Jason A; Hudock, Kristin M; Sullivan, Spencer K; Herrera, Pamela; Sullivan, Lisa M; Gadue, Paul; French, Deborah L (2015. )Generation of poikiloderma with neutropenia (PN) induced pluripotent stem cells (iPSCs).Stem cell research, ,15 (3 ),595-7

Shreenivas, Satya S; Lilly, Scott M; Szeto, Wilson Y; Desai, Nimesh; Anwaruddin, Saif; Bavaria, Joseph E; Hudock, Kristin M; Thourani, Vinod H; Makkar, Raj; Pichard, Augusto; Webb, John; Dewey, Todd; Kapadia, Samir; Suri, Rakesh M; Xu, Ke; Leon, Martin B; Herrmann, Howard C (2015. )Cardiopulmonary bypass and intra-aortic balloon pump use is associated with higher short and long term mortality after transcatheter aortic valve replacement: a PARTNER trial substudy.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, ,86 (2 ),316-22

Paluru, Prasuna; Hudock, Kristin M; Cheng, Xin; Mills, Jason A; Ying, Lei; Galvão, Aline M; Lu, Lin; Tiyaboonchai, Amita; Sim, Xiuli; Sullivan, Spencer K; French, Deborah L; Gadue, Paul (2014. )The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cells.Stem cell research, ,12 (2 ),441-51

Hudock, Kristin M; Liu, Yuhong; Mei, Junjie; Marino, Roberta C; Hale, Jason E; Dai, Ning; Worthen, G Scott (2012. )Delayed resolution of lung inflammation in Il-1rn-/- mice reflects elevated IL-17A/granulocyte colony-stimulating factor expression.American journal of respiratory cell and molecular biology, ,47 (4 ),436-44

Mei, Junjie; Liu, Yuhong; Dai, Ning; Hoffmann, Christian; Hudock, Kristin M; Zhang, Peggy; Guttentag, Susan H; Kolls, Jay K; Oliver, Paula M; Bushman, Frederic D; Worthen, G Scott (2012. )Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice.The Journal of clinical investigation, ,122 (3 ),974-86

Paris, Andrew J; Liu, Yuhong; Mei, Junjie; Dai, Ning; Guo, Lei; Spruce, Lynn A; Hudock, Kristin M; Brenner, Jacob S; Zacharias, William J; Mei, Hankun D; Slamowitz, April R; Bhamidipati, Kartik; Beers, Michael F; Seeholzer, Steven H; Morrisey, Edward E; Worthen, G Scott (2016. )Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury.American journal of physiology. Lung cellular and molecular physiology, ,311 (6 ),L1062-L1075

Hudock, K M; Hafeez, A; Kaltenbach, J C (1997. )Cell Localization of Lectin Binding in Microciona prolifera Sponge.The Biological bulletin, ,193 (2 ),241-242

Koo, C W; Gupta, N; Baliff, J P; Hudock, K; Haas, A R (2011. )A tale of two sisters: biomass fuel exposure-related lung disease.Clinical radiology, ,66 (2 ),190-3

Kaltenbach JC, Hudock KM, Burger MM, Miseciv G, Kuhns WJ. (1996. )Masking effects of sulfate upon Microciona sponge cell carbohydrates: A lectin histochemical study. .The Biological Bulletin, ,191 (2 ),296

Hudock, Kristin M; Clancy, John Paul (2017. )An update on new and emerging therapies for cystic fibrosis.Expert opinion on emerging drugs, ,22 (4 ),331-346

Kaltenbach, J C; Hudock, K M; Burger, M M; Misevic, G; Kuhns, W J (1996. )Masking Effects of Sulfate upon Microciona Sponge Cell Carbohydrates: A Lectin Histochemical Study.The Biological bulletin, ,191 (2 ),296-297

Kramer, Elizabeth L; Madala, Satish K; Hudock, Kristin M; Davidson, Cynthia; Clancy, John P (2020. )Subacute TGF? Exposure Drives Airway Hyperresponsiveness in Cystic Fibrosis Mice through the PI3K Pathway.American journal of respiratory cell and molecular biology, ,62 (5 ),657-667

Hudock, Kristin M; Collins, Margaret S; Imbrogno, Michelle; Snowball, John; Kramer, Elizabeth L; Brewington, John J; Gollomp, Kandace; McCarthy, Cormac; Ostmann, Alicia J; Kopras, Elizabeth J; Davidson, Cynthia R; Srdiharan, Anusha; Arumugam, Paritha; Sengupta, Shaon; Xu, Yan; Worthen, G Scott; Trapnell, Bruce C; Clancy, John Paul (2020. )Neutrophil extracellular traps activate IL-8 and IL-1 expression in human bronchial epithelia.American journal of physiology. Lung cellular and molecular physiology, ,

Gollomp, Kandace; Sarkar, Amrita; Harikumar, Sanjiv; Seeholzer, Steven H; Arepally, Gowthami M; Hudock, Kristin; Rauova, Lubica; Kowalska, M Anna; Poncz, Mortimer (2020. )Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis.Blood, ,135 (10 ),743-754

, ; Ginde, Adit A; Brower, Roy G; Caterino, Jeffrey M; Finck, Lani; Banner-Goodspeed, Valerie M; Grissom, Colin K; Hayden, Douglas; Hough, Catherine L; Hyzy, Robert C; Khan, Akram; Levitt, Joseph E; Park, Pauline K; Ringwood, Nancy; Rivers, Emanuel P; Self, Wesley H; Shapiro, Nathan I; Thompson, B Taylor; Yealy, Donald M; Talmor, Daniel (2019. )Early High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients.The New England journal of medicine, ,381 (26 ),2529-2540

, ; Moss, Marc; Huang, David T; Brower, Roy G; Ferguson, Niall D; Ginde, Adit A; Gong, M N; Grissom, Colin K; Gundel, Stephanie; Hayden, Douglas; Hite, R Duncan; Hou, Peter C; Hough, Catherine L; Iwashyna, Theodore J; Khan, Akram; Liu, Kathleen D; Talmor, Daniel; Thompson, B Taylor; Ulysse, Christine A; Yealy, Donald M; Angus, Derek C (2019. )Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.The New England journal of medicine, ,380 (21 ),1997-2008

Other Publications

Hudock, KM. (2012. )Air Embolism: Clinician Review .Decision Support in Medicine,

Hudock, KM. (2016. )Air Embolism: Clinician Review .Decision Support in Medicine,

Book Chapter

Hudock, KM, Lanken, PN. (2013 )Liberation and Weaning from Mechanical Ventilation and Extubation The Intensive Care Manual, 2nd Edition .

Contact Information

Academic - UC Department of Internal Medicine
Division of Pulmonary, Critical Care & Sleep Medicine
Cincinnati  Ohio, 45267-0564
Phone: 513-558-4831
Fax: 513-558-4858

Research - CCHMC Division of Pulmonary Biology
R4027, CCHMC
Cincinnati  Ohio, 45229