Hyacinth Hyacinth

Hyacinth Idu Hyacinth , MD, PhD, MPH

Associate Professor

Medical Sciences Building

7210

COM Neu Cognitive - 0536

Education

MBBS: University of Jos Jos, Nigeria, 2007 (Faculty of Medicine Sciences )

Residency: Jos University Teaching Hospital Jos, Nigeria, 2008

MPH: University of Liverpool Liverpool, United Kingdom, 2012

Fellowship: Morehouse School of Medicine Atlanta, GA, 2012 (Genomics and Hemoglobinopathies)

Post-Doctoral Scholar: Medical University of South Carolina Charleston, SC, 2014 (Stroke and Neuroscience)

Fellowship: Emory University School of Medicine Atlanta, GA, 2014 (Bone Marrow Transplantation)

PhD: Walden University Minneapolis, Minnesota, 2015

Research and Practice Interests

Broadly, my research is focused on understanding the biological basis for disparity in stroke, cognitive impairment and dementia. Specifically, my research has and is examining the role of the sickle cell mutation and other genetic variants on the incidence and prevalence of cerebral macro and microvascular pathologies in individuals of African ancestry. In addition, we also seek to define the mechanisms by which genetic variation in populations, results in differential risk, susceptibility and/or progression of cerebrovascular diseases (stroke, cognitive impairment and dementia)

Positions and Work Experience

11-01-2014 -05-31-2017 Instructor, Emory University School of Medicine, Atlanta, GA

06-01-2017 -01-31-2021 Assistant Professor, Emory University School of Medicine, Atlanta, GA

02-01-2021 - Associate Professor and Whitaker and Price Chair for Brain Health, University of Cincinnati, Cincinnati, OH

Research Support

Grant: #R01HL138423 Investigators:Hyacinth, Hyacinth 07-01-2021 -06-30-2022 National Heart, Lung and Blood Institute Mechanism of cerebral vaculopathy and stroke in sickle cell disease Role:PI 405,000 Active Type:Grant Level:National

Grant: #R01HL138423 Investigators:Hyacinth, Hyacinth 07-01-2021 -06-30-2022 National Institute on Aging and National Heart, Lung and Blood Institute The impact of the combined presence of sickle cell mutation and AD/ADRD gene variants on development of cognitive deficits and racial disparity in AD/ADRD Role:PI 405,000.00 Active Type:Grant

Grant: #R01HL156024 07-01-2021 -11-30-2025 National Heart, Lung and Blood Institute Minocycline as a potential therapy for neuroinflammation and cognitive deficit in sickle cell disease Role:PI 286061.00 Active Level:Federal

Grant: #R01AG072592 09-15-2021 -05-31-2026 National Institute on Aging Cerebral small vessel disease burden and racial disparity in vascular cognitive impairment and Alzheimer's disease and its related dementias (transfer application) Role:PI 1505134.00 Awarded Level:Federal

Grant: #R01HL156024 Investigators:Hyacinth, Hyacinth; Niu, Liang 07-01-2021 -11-30-2025 National Heart, Lung and Blood Institute Minocycline as a potential therapy for neuroinflammation and cognitive deficit in sickle cell disease Role:PI 918007.00 Active Level:Federal

Publications

Peer Reviewed Publications

Chen, Nemin; Caruso, Christina; Alonso, Alvaro; Derebail, Vimal K; Kshirsagar, Abhijit V; Sharrett, A Richey; Key, Nigel S; Gottesman, Rebecca F; Grove, Megan L; Bressler, Jan; Boerwinkle, Eric; Windham, B Gwen; Mosley, Thomas H; Hyacinth, Hyacinth I (2020. ) Corrigendum to 'Association of sickle cell trait with measures of cognitive function and dementia in African Americans' eNeurologicalSci, Vol. 16 (2019), 100,201.eNeurologicalSci, , 21 ,100281 More Information

Hardy, Raven A; Rached, Noor Abi; Jones, Jayre A; Archer, David R; Hyacinth, Hyacinth I (2020. ) Role of age and neuroinflammation in the mechanism of cognitive deficits in sickle cell disease.Experimental biology and medicine (Maywood, N.J.), , 1535370220958011 More Information

Keene, Keith L; Hyacinth, Hyacinth I; Bis, Joshua C; Kittner, Steven J; Mitchell, Braxton D; Cheng, Yu-Ching; Pare, Guillaume; Chong, Michael; O'Donnell, Martin; Meschia, James F; Chen, Wei-Min; Sale, Michèle M; Rich, Stephen S; Nalls, Mike A; Zonderman, Alan B; Evans, Michele K; Wilson, James G; Correa, Adolfo; Markus, Hugh S; Traylor, Matthew; Lewis, Cathryn M; Carty, Cara L; Reiner, Alexander; Haessler, Jeff; Langefeld, Carl D; Gottesman, Rebecca; Mosley, Thomas H; Woo, Daniel; Yaffe, Kristine; Liu, YongMei; Longstreth, William T; Psaty, Bruce M; Kooperberg, Charles; Lange, Leslie A; Sacco, Ralph; Rundek, Tatjana; Lee, Jin-Moo; Cruchaga, Carlos; Furie, Karen L; Arnett, Donna K; Benavente, Oscar R; Grewal, Raji P; Peddareddygari, Leema Reddy; Dichgans, Martin; Malik, Rainer; Worrall, Bradford B; Fornage, Myriam (2020. ) Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke.Stroke, , 51 (8 ) ,2454-2463 More Information

Holshouser, Steven; Cafiero, Rebecca; Robinson, Mayra; Kirkpatrick, Joy; Casero, Robert A; Hyacinth, Hyacinth I; Woster, Patrick M (2020. ) Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease.ACS omega, , 5 (24 ) ,14750-14758 More Information

Hyacinth, Hyacinth I; Idris, Ibrahim M (2020. ) Cognitive deficit in sickle cell disease: Is hydroxyurea part of the story?.British journal of haematology, , 189 (6 ) ,1014-1015 More Information

Chen, Nemin; Caruso, Christina; Alonso, Alvaro; Derebail, Vimal K; Kshirsagar, Abhijit V; Sharrett, A Richey; Key, Nigel S; Gottesman, Rebecca F; Grove, Megan L; Bressler, Jan; Boerwinkle, Eric; Windham, B Gwen; Mosley, Thomas H; Hyacinth, Hyacinth I (2019. ) Association of sickle cell trait with measures of cognitive function and dementia in African Americans.eNeurologicalSci, , 16 ,100201 More Information

Malik, Rainer; Chauhan, Ganesh; Traylor, Matthew; Sargurupremraj, Muralidharan; Okada, Yukinori; Mishra, Aniket; Rutten-Jacobs, Loes; Giese, Anne-Katrin; van der Laan, Sander W; Gretarsdottir, Solveig; Anderson, Christopher D; Chong, Michael; Adams, Hieab H H; Ago, Tetsuro; Almgren, Peter; Amouyel, Philippe; Ay, Hakan; Bartz, Traci M; Benavente, Oscar R; Bevan, Steve; Boncoraglio, Giorgio B; Brown, Robert D; Butterworth, Adam S; Carrera, Caty; Carty, Cara L; Chasman, Daniel I; Chen, Wei-Min; Cole, John W; Correa, Adolfo; Cotlarciuc, Ioana; Cruchaga, Carlos; Danesh, John; de Bakker, Paul I W; DeStefano, Anita L; den Hoed, Marcel; Duan, Qing; Engelter, Stefan T; Falcone, Guido J; Gottesman, Rebecca F; Grewal, Raji P; Gudnason, Vilmundur; Gustafsson, Stefan; Haessler, Jeffrey; Harris, Tamara B; Hassan, Ahamad; Havulinna, Aki S; Heckbert, Susan R; Holliday, Elizabeth G; Howard, George; Hsu, Fang-Chi; Hyacinth, Hyacinth I; Ikram, M Arfan; Ingelsson, Erik; Irvin, Marguerite R; Jian, Xueqiu; Jiménez-Conde, Jordi; Johnson, Julie A; Jukema, J Wouter; Kanai, Masahiro; Keene, Keith L; Kissela, Brett M; Kleindorfer, Dawn O; Kooperberg, Charles; Kubo, Michiaki; Lange, Leslie A; Langefeld, Carl D; Langenberg, Claudia; Launer, Lenore J; Lee, Jin-Moo; Lemmens, Robin; Leys, Didier; Lewis, Cathryn M; Lin, Wei-Yu; Lindgren, Arne G; Lorentzen, Erik; Magnusson, Patrik K; Maguire, Jane; Manichaikul, Ani; McArdle, Patrick F; Meschia, James F; Mitchell, Braxton D; Mosley, Thomas H; Nalls, Michael A; Ninomiya, Toshiharu; O'Donnell, Martin J; Psaty, Bruce M; Pulit, Sara L; Rannikmäe, Kristiina; Reiner, Alexander P; Rexrode, Kathryn M; Rice, Kenneth; Rich, Stephen S; Ridker, Paul M; Rost, Natalia S; Rothwell, Peter M; Rotter, Jerome I; Rundek, Tatjana; Sacco, Ralph L; Sakaue, Saori; Sale, Michele M; Salomaa, Veikko; Sapkota, Bishwa R; Schmidt, Reinhold; Schmidt, Carsten O; Schminke, Ulf; Sharma, Pankaj; Slowik, Agnieszka; Sudlow, Cathie L M; Tanislav, Christian; Tatlisumak, Turgut; Taylor, Kent D; Thijs, Vincent N S; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tiedt, Steffen; Trompet, Stella; Tzourio, Christophe; van Duijn, Cornelia M; Walters, Matthew; Wareham, Nicholas J; Wassertheil-Smoller, Sylvia; Wilson, James G; Wiggins, Kerri L; Yang, Qiong; Yusuf, Salim ; Bis, Joshua C; Pastinen, Tomi; Ruusalepp, Arno; Schadt, Eric E; Koplev, Simon; Björkegren, Johan L M; Codoni, Veronica; Civelek, Mete; Smith, Nicholas L; Trégouët, David A; Christophersen, Ingrid E; Roselli, Carolina; Lubitz, Steven A; Ellinor, Patrick T; Tai, E Shyong; Kooner, Jaspal S; Kato, Norihiro; He, Jiang; van der Harst, Pim; Elliott, Paul; Chambers, John C; Takeuchi, Fumihiko; Johnson, Andrew D ; Sanghera, Dharambir K; Melander, Olle; Jern, Christina; Strbian, Daniel; Fernandez-Cadenas, Israel; Longstreth, W T; Rolfs, Arndt; Hata, Jun; Woo, Daniel; Rosand, Jonathan; Pare, Guillaume; Hopewell, Jemma C; Saleheen, Danish; Stefansson, Kari; Worrall, Bradford B; Kittner, Steven J; Seshadri, Sudha; Fornage, Myriam; Markus, Hugh S; Howson, Joanna M M; Kamatani, Yoichiro; Debette, Stephanie; Dichgans, Martin (2019. ) Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.Nature genetics, , 51 (7 ) ,1192-1193 More Information

Cahill, Christina R; Leach, Justin M; McClure, Leslie A; Irvin, Marguerite Ryan; Zakai, Neil A; Naik, Rakhi; Unverzagt, Frederick; Wadley, Virginia G; Hyacinth, Hyacinth I; Manly, Jennifer; Judd, Suzanne E; Winkler, Cheryl; Cushman, Mary Sickle cell trait and risk of cognitive impairment in African-Americans: The REGARDS cohort.EClinicalMedicine, , 11 ,27-33 More Information

Larsson, Susanna C; Traylor, Matthew; Burgess, Stephen; Boncoraglio, Giorgio B; Jern, Christina; Michaëlsson, Karl; Markus, Hugh S (2019. ) Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study.Neurology, , 92 (9 ) ,e944-e950 More Information

Hyacinth, Hyacinth I; Sugihara, Courtney L; Spencer, Thomas L; Archer, David R; Shih, Andy Y (2019. ) Higher prevalence of spontaneous cerebral vasculopathy and cerebral infarcts in a mouse model of sickle cell disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , 39 (2 ) ,342-351 More Information

Chauhan, Ganesh; Adams, Hieab H H; Satizabal, Claudia L; Bis, Joshua C; Teumer, Alexander; Sargurupremraj, Muralidharan; Hofer, Edith; Trompet, Stella; Hilal, Saima; Smith, Albert Vernon; Jian, Xueqiu; Malik, Rainer; Traylor, Matthew; Pulit, Sara L; Amouyel, Philippe; Mazoyer, Bernard; Zhu, Yi-Cheng; Kaffashian, Sara; Schilling, Sabrina; Beecham, Gary W; Montine, Thomas J; Schellenberg, Gerard D; Kjartansson, Olafur; Guðnason, Vilmundur; Knopman, David S; Griswold, Michael E; Windham, B Gwen; Gottesman, Rebecca F; Mosley, Thomas H; Schmidt, Reinhold; Saba, Yasaman; Schmidt, Helena; Takeuchi, Fumihiko; Yamaguchi, Shuhei; Nabika, Toru; Kato, Norihiro; Rajan, Kumar B; Aggarwal, Neelum T; De Jager, Philip L; Evans, Denis A; Psaty, Bruce M; Rotter, Jerome I; Rice, Kenneth; Lopez, Oscar L; Liao, Jiemin; Chen, Christopher; Cheng, Ching-Yu; Wong, Tien Y; Ikram, Mohammad K; van der Lee, Sven J; Amin, Najaf; Chouraki, Vincent; DeStefano, Anita L; Aparicio, Hugo J; Romero, Jose R; Maillard, Pauline; DeCarli, Charles; Wardlaw, Joanna M; Hernández, Maria Del C Valdés; Luciano, Michelle; Liewald, David; Deary, Ian J; Starr, John M; Bastin, Mark E; Muñoz Maniega, Susana; Slagboom, P Eline; Beekman, Marian; Deelen, Joris; Uh, Hae-Won; Lemmens, Robin; Brodaty, Henry; Wright, Margaret J; Ames, David; Boncoraglio, Giorgio B; Hopewell, Jemma C; Beecham, Ashley H; Blanton, Susan H; Wright, Clinton B; Sacco, Ralph L; Wen, Wei; Thalamuthu, Anbupalam; Armstrong, Nicola J; Chong, Elizabeth; Schofield, Peter R; Kwok, John B; van der Grond, Jeroen; Stott, David J; Ford, Ian; Jukema, J Wouter; Vernooij, Meike W; Hofman, Albert; Uitterlinden, André G; van der Lugt, Aad; Wittfeld, Katharina; Grabe, Hans J; Hosten, Norbert; von Sarnowski, Bettina; Völker, Uwe; Levi, Christopher; Jimenez-Conde, Jordi; Sharma, Pankaj; Sudlow, Cathie L M; Rosand, Jonathan; Woo, Daniel; Cole, John W; Meschia, James F; Slowik, Agnieszka; Thijs, Vincent; Lindgren, Arne; Melander, Olle; Grewal, Raji P; Rundek, Tatjana; Rexrode, Kathy; Rothwell, Peter M; Arnett, Donna K; Jern, Christina; Johnson, Julie A; Benavente, Oscar R; Wasssertheil-Smoller, Sylvia; Lee, Jin-Moo; Wong, Quenna; Mitchell, Braxton D; Rich, Stephen S; McArdle, Patrick F; Geerlings, Mirjam I; van der Graaf, Yolanda; de Bakker, Paul I W; Asselbergs, Folkert W; Srikanth, Velandai; Thomson, Russell; McWhirter, Rebekah; Moran, Chris; Callisaya, Michele; Phan, Thanh; Rutten-Jacobs, Loes C A; Bevan, Steve; Tzourio, Christophe; Mather, Karen A; Sachdev, Perminder S; van Duijn, Cornelia M; Worrall, Bradford B; Dichgans, Martin; Kittner, Steven J; Markus, Hugh S; Ikram, Mohammad A; Fornage, Myriam; Launer, Lenore J; Seshadri, Sudha; Longstreth, W T; Debette, Stéphanie (2019. ) Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.Neurology, , More Information

Douce, Daniel R; Soliman, Elsayed Z; Naik, Rakhi; Hyacinth, Hyacinth I; Cushman, Mary; Winkler, Cheryl A; Howard, George; Lange, Ethan M; Lange, Leslie A; Irvin, Marguerite R; Zakai, Neil A Association of sickle cell trait with atrial fibrillation: The REGARDS cohort.Journal of electrocardiology, , 55 ,1-5 More Information

Franceschini, Nora; Giambartolomei, Claudia; de Vries, Paul S; Finan, Chris; Bis, Joshua C; Huntley, Rachael P; Lovering, Ruth C; Tajuddin, Salman M; Winkler, Thomas W; Graff, Misa; Kavousi, Maryam; Dale, Caroline; Smith, Albert V; Hofer, Edith; van Leeuwen, Elisabeth M; Nolte, Ilja M; Lu, Lingyi; Scholz, Markus; Sargurupremraj, Muralidharan; Pitkänen, Niina; Franzén, Oscar; Joshi, Peter K; Noordam, Raymond; Marioni, Riccardo E; Hwang, Shih-Jen; Musani, Solomon K; Schminke, Ulf; Palmas, Walter; Isaacs, Aaron; Correa, Adolfo; Zonderman, Alan B; Hofman, Albert; Teumer, Alexander; Cox, Amanda J; Uitterlinden, André G; Wong, Andrew; Smit, Andries J; Newman, Anne B; Britton, Annie; Ruusalepp, Arno; Sennblad, Bengt; Hedblad, Bo; Pasaniuc, Bogdan; Penninx, Brenda W; Langefeld, Carl D; Wassel, Christina L; Tzourio, Christophe; Fava, Cristiano; Baldassarre, Damiano; O'Leary, Daniel H; Teupser, Daniel; Kuh, Diana; Tremoli, Elena; Mannarino, Elmo; Grossi, Enzo; Boerwinkle, Eric; Schadt, Eric E; Ingelsson, Erik; Veglia, Fabrizio; Rivadeneira, Fernando; Beutner, Frank; Chauhan, Ganesh; Heiss, Gerardo; Snieder, Harold; Campbell, Harry; Völzke, Henry; Markus, Hugh S; Deary, Ian J; Jukema, J Wouter; de Graaf, Jacqueline; Price, Jacqueline; Pott, Janne; Hopewell, Jemma C; Liang, Jingjing; Thiery, Joachim; Engmann, Jorgen; Gertow, Karl; Rice, Kenneth; Taylor, Kent D; Dhana, Klodian; Kiemeney, Lambertus A L M; Lind, Lars; Raffield, Laura M; Launer, Lenore J; Holdt, Lesca M; Dörr, Marcus; Dichgans, Martin; Traylor, Matthew; Sitzer, Matthias; Kumari, Meena; Kivimaki, Mika; Nalls, Mike A; Melander, Olle; Raitakari, Olli; Franco, Oscar H; Rueda-Ochoa, Oscar L; Roussos, Panos; Whincup, Peter H; Amouyel, Philippe; Giral, Philippe; Anugu, Pramod; Wong, Quenna; Malik, Rainer; Rauramaa, Rainer; Burkhardt, Ralph; Hardy, Rebecca; Schmidt, Reinhold; de Mutsert, Renée; Morris, Richard W; Strawbridge, Rona J; Wannamethee, S Goya; Hägg, Sara; Shah, Sonia; McLachlan, Stela; Trompet, Stella; Seshadri, Sudha; Kurl, Sudhir; Heckbert, Susan R; Ring, Susan; Harris, Tamara B; Lehtimäki, Terho; Galesloot, Tessel E; Shah, Tina; de Faire, Ulf; Plagnol, Vincent; Rosamond, Wayne D; Post, Wendy; Zhu, Xiaofeng; Zhang, Xiaoling; Guo, Xiuqing; Saba, Yasaman ; Dehghan, Abbas; Seldenrijk, Adrie; Morrison, Alanna C; Hamsten, Anders; Psaty, Bruce M; van Duijn, Cornelia M; Lawlor, Deborah A; Mook-Kanamori, Dennis O; Bowden, Donald W; Schmidt, Helena; Wilson, James F; Wilson, James G; Rotter, Jerome I; Wardlaw, Joanna M; Deanfield, John; Halcox, Julian; Lyytikäinen, Leo-Pekka; Loeffler, Markus; Evans, Michele K; Debette, Stéphanie; Humphries, Steve E; Völker, Uwe; Gudnason, Vilmundur; Hingorani, Aroon D; Björkegren, Johan L M; Casas, Juan P; O'Donnell, Christopher J (2018. ) GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.Nature communications, , 9 (1 ) ,5141 More Information

Hyacinth, Hyacinth I (2018. ) The injured brain might need more fat!.EBioMedicine, , 33 ,12-13 More Information

Hyacinth, Hyacinth I; Carty, Cara L; Seals, Samantha R; Irvin, Marguerite R; Naik, Rakhi P; Burke, Gregory L; Zakai, Neil A; Wilson, James G; Franceschini, Nora; Winkler, Cheryl A; David, Victor A; Kopp, Jeffrey B; Judd, Suzanne E; Adams, Robert J; Longstreth, W T; Egede, Leonard; Lackland, Daniel T; Taylor, Herman; Manson, JoAnn E; Howard, Virginia; Allison, Matthew; Gee, Beatrice E; Correa, Adolfo; Safford, Monika M; Arnett, Donna K; Howard, George; Reiner, Alexander P; Cushman, Mary (2018. ) Association of Sickle Cell Trait With Ischemic Stroke Among African Americans: A Meta-analysis.JAMA neurology, , 75 (7 ) ,802-807 More Information

Gutiérrez, Orlando M; Irvin, Marguerite R; Chaudhary, Ninad S; Cushman, Mary; Zakai, Neil A; David, Victor A; Limou, Sophie; Pamir, Nathalie; Reiner, Alex P; Naik, Rakhi P; Sale, Michele M; Safford, Monika M; Hyacinth, Hyacinth I; Judd, Suzanne E; Kopp, Jeffrey B; Winkler, Cheryl A (2018. ) APOL1 Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults.Circulation. Genomic and precision medicine, , 11 (6 ) ,e002098 More Information

Hyacinth, Hyacinth I (2018. ) Sickle-cell anaemia needs more food?.The Lancet. Haematology, , 5 (4 ) ,e130-e131 More Information

Malik, Rainer; Chauhan, Ganesh; Traylor, Matthew; Sargurupremraj, Muralidharan; Okada, Yukinori; Mishra, Aniket; Rutten-Jacobs, Loes; Giese, Anne-Katrin; van der Laan, Sander W; Gretarsdottir, Solveig; Anderson, Christopher D; Chong, Michael; Adams, Hieab H H; Ago, Tetsuro; Almgren, Peter; Amouyel, Philippe; Ay, Hakan; Bartz, Traci M; Benavente, Oscar R; Bevan, Steve; Boncoraglio, Giorgio B; Brown, Robert D; Butterworth, Adam S; Carrera, Caty; Carty, Cara L; Chasman, Daniel I; Chen, Wei-Min; Cole, John W; Correa, Adolfo; Cotlarciuc, Ioana; Cruchaga, Carlos; Danesh, John; de Bakker, Paul I W; DeStefano, Anita L; den Hoed, Marcel; Duan, Qing; Engelter, Stefan T; Falcone, Guido J; Gottesman, Rebecca F; Grewal, Raji P; Gudnason, Vilmundur; Gustafsson, Stefan; Haessler, Jeffrey; Harris, Tamara B; Hassan, Ahamad; Havulinna, Aki S; Heckbert, Susan R; Holliday, Elizabeth G; Howard, George; Hsu, Fang-Chi; Hyacinth, Hyacinth I; Ikram, M Arfan; Ingelsson, Erik; Irvin, Marguerite R; Jian, Xueqiu; Jiménez-Conde, Jordi; Johnson, Julie A; Jukema, J Wouter; Kanai, Masahiro; Keene, Keith L; Kissela, Brett M; Kleindorfer, Dawn O; Kooperberg, Charles; Kubo, Michiaki; Lange, Leslie A; Langefeld, Carl D; Langenberg, Claudia; Launer, Lenore J; Lee, Jin-Moo; Lemmens, Robin; Leys, Didier; Lewis, Cathryn M; Lin, Wei-Yu; Lindgren, Arne G; Lorentzen, Erik; Magnusson, Patrik K; Maguire, Jane; Manichaikul, Ani; McArdle, Patrick F; Meschia, James F; Mitchell, Braxton D; Mosley, Thomas H; Nalls, Michael A; Ninomiya, Toshiharu; O'Donnell, Martin J; Psaty, Bruce M; Pulit, Sara L; Rannikmäe, Kristiina; Reiner, Alexander P; Rexrode, Kathryn M; Rice, Kenneth; Rich, Stephen S; Ridker, Paul M; Rost, Natalia S; Rothwell, Peter M; Rotter, Jerome I; Rundek, Tatjana; Sacco, Ralph L; Sakaue, Saori; Sale, Michele M; Salomaa, Veikko; Sapkota, Bishwa R; Schmidt, Reinhold; Schmidt, Carsten O; Schminke, Ulf; Sharma, Pankaj; Slowik, Agnieszka; Sudlow, Cathie L M; Tanislav, Christian; Tatlisumak, Turgut; Taylor, Kent D; Thijs, Vincent N S; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tiedt, Steffen; Trompet, Stella; Tzourio, Christophe; van Duijn, Cornelia M; Walters, Matthew; Wareham, Nicholas J; Wassertheil-Smoller, Sylvia; Wilson, James G; Wiggins, Kerri L; Yang, Qiong; Yusuf, Salim ; Bis, Joshua C; Pastinen, Tomi; Ruusalepp, Arno; Schadt, Eric E; Koplev, Simon; Björkegren, Johan L M; Codoni, Veronica; Civelek, Mete; Smith, Nicholas L; Trégouët, David A; Christophersen, Ingrid E; Roselli, Carolina; Lubitz, Steven A; Ellinor, Patrick T; Tai, E Shyong; Kooner, Jaspal S; Kato, Norihiro; He, Jiang; van der Harst, Pim; Elliott, Paul; Chambers, John C; Takeuchi, Fumihiko; Johnson, Andrew D ; Sanghera, Dharambir K; Melander, Olle; Jern, Christina; Strbian, Daniel; Fernandez-Cadenas, Israel; Longstreth, W T; Rolfs, Arndt; Hata, Jun; Woo, Daniel; Rosand, Jonathan; Pare, Guillaume; Hopewell, Jemma C; Saleheen, Danish; Stefansson, Kari; Worrall, Bradford B; Kittner, Steven J; Seshadri, Sudha; Fornage, Myriam; Markus, Hugh S; Howson, Joanna M M; Kamatani, Yoichiro; Debette, Stephanie; Dichgans, Martin (2018. ) Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.Nature genetics, , 50 (4 ) ,524-537 More Information

Hartmann, David A; Hyacinth, Hyacinth I; Liao, Francesca-Fang; Shih, Andy Y (2018. ) Does pathology of small venules contribute to cerebral microinfarcts and dementia?.Journal of neurochemistry, , 144 (5 ) ,517-526 More Information

Shih, Andy Y; Hyacinth, Hyacinth I; Hartmann, David A; van Veluw, Susanne J (2018. ) Rodent Models of Cerebral Microinfarct and Microhemorrhage.Stroke, , 49 (3 ) ,803-810 More Information

Coleman, Elisheva R; Moudgal, Rohitha; Lang, Kathryn; Hyacinth, Hyacinth I; Awosika, Oluwole O; Kissela, Brett M; Feng, Wuwei (2017. ) Early Rehabilitation After Stroke: a Narrative Review.Current atherosclerosis reports, , 19 (12 ) ,59 More Information

Wright, Racquel J; Lee, Ken S; Hyacinth, Hyacinth I; Hibbert, Jacqueline M; Reid, Marvin E; Wheatley, Andrew O; Asemota, Helen N (2017. ) An Investigation of the Antioxidant Capacity in Extracts from Moringa oleifera Plants Grown in Jamaica.Plants (Basel, Switzerland), , 6 (4 ) , More Information

Bello, Natalie A; Hyacinth, Hyacinth I; Roetker, Nicholas S; Seals, Samantha R; Naik, Rakhi P; Derebail, Vimal K; Kshirsagar, Abhijit V; Key, Nigel S; Wilson, James G; Correa, Adolfo; Adams, Robert J; Egede, Leonard D; Longstreth, W T; Choudhary, Gaurav; Gee, Beatrice E; Hughes, Austin L; Shah, Amil M; Manson, JoAnn E; Allison, Matthew; Burke, Gregory L; Folsom, Aaron R; Carty, Cara L; Reiner, Alexander P; Solomon, Scott D; Konety, Suma H (2017. ) Sickle cell trait is not associated with an increased risk of heart failure or abnormalities of cardiac structure and function.Blood, , 129 (6 ) ,799-801 More Information

Hyacinth, Hyacinth I; Adams, Robert J; Greenberg, Charles S; Voeks, Jenifer H; Hill, Allyson; Hibbert, Jacqueline M; Gee, Beatrice E (2015. ) Effect of Chronic Blood Transfusion on Biomarkers of Coagulation Activation and Thrombin Generation in Sickle Cell Patients at Risk for Stroke.PloS one, , 10 (8 ) ,e0134193 More Information

Capers, Patrice L; Hyacinth, Hyacinth I; Cue, Shayla; Chappa, Prasanthi; Vikulina, Tatyana; Roser-Page, Susanne; Weitzmann, M Neale; Archer, David R; Newman, Gale W; Quarshie, Alexander; Stiles, Jonathan K; Hibbert, Jacqueline M (2015. ) Body composition and grip strength are improved in transgenic sickle mice fed a high-protein diet.Journal of nutritional science, , 4 ,e6 More Information

Naik, Rakhi P; Derebail, Vimal K; Grams, Morgan E; Franceschini, Nora; Auer, Paul L; Peloso, Gina M; Young, Bessie A; Lettre, Guillaume; Peralta, Carmen A; Katz, Ronit; Hyacinth, Hyacinth I; Quarells, Rakale C; Grove, Megan L; Bick, Alexander G; Fontanillas, Pierre; Rich, Stephen S; Smith, Joshua D; Boerwinkle, Eric; Rosamond, Wayne D; Ito, Kaoru; Lanzkron, Sophie; Coresh, Josef; Correa, Adolfo; Sarto, Gloria E; Key, Nigel S; Jacobs, David R; Kathiresan, Sekar; Bibbins-Domingo, Kirsten; Kshirsagar, Abhijit V; Wilson, James G; Reiner, Alexander P (2014. ) Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans.JAMA, , 312 (20 ) ,2115-25 More Information

Malek, Angela M; Adams, Robert J; Debenham, Ellen; Boan, Andrea D; Kazley, Abby S; Hyacinth, Hyacinth I; Voeks, Jenifer H; Lackland, Daniel T (2014. ) Patient awareness and perception of stroke symptoms and the use of 911.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , 23 (9 ) ,2362-71 More Information

Manci, Elizabeth Ann; Hyacinth, Hyacinth I; Capers, Patrice L; Archer, David R; Pitts, Sydney; Ghosh, Samit; Patrickson, John; Titford, Michael E; Ofori-Acquah, Solomon F; Hibbert, Jacqueline M (2014. ) High protein diet attenuates histopathologic organ damage and vascular leakage in transgenic murine model of sickle cell anemia.Experimental biology and medicine (Maywood, N.J.), , 239 (8 ) ,966-974 More Information

Hyacinth, Hyacinth I; Adams, Robert J; Voeks, Jenifer H; Hibbert, Jacqueline M; Gee, Beatrice E (2014. ) Frequent red cell transfusions reduced vascular endothelial activation and thrombogenicity in children with sickle cell anemia and high stroke risk.American journal of hematology, , 89 (1 ) ,47-51 More Information

Hyacinth, Hyacinth I; Capers, Patrice L; Archer, David R; Hibbert, Jacqueline M (2014. ) TNF-?, IFN-?, IL-10, and IL-4 levels were elevated in a murine model of human sickle cell anemia maintained on a high protein/calorie diet.Experimental biology and medicine (Maywood, N.J.), , 239 (1 ) ,65-70 More Information

Ellis, Charles; Hyacinth, Hyacinth I; Beckett, Jamie; Feng, Wuwei; Chimowitz, Marc; Ovbiagele, Bruce; Lackland, Dan; Adams, Robert (2014. ) Racial/Ethnic differences in poststroke rehabilitation outcomes.Stroke research and treatment, , 2014 ,950746 More Information

Hyacinth, Hyacinth I; Adekeye, Oluwatoyosi A; Yilgwan, Christopher S (2013. ) Malnutrition in Sickle Cell Anemia: Implications for Infection, Growth, and Maturation.Journal of social, behavioral and health sciences, , 7 (1 ) , More Information

Hyacinth, Hyacinth I; Gee, Beatrice E; Adamkiewicz, Thomas V; Adams, Robert J; Kutlar, Abdullah; Stiles, Jonathan K; Hibbert, Jacqueline M (2012. ) Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemia.Cytokine, , 60 (1 ) ,302-8 More Information

Yilgwan, Christopher S; Utoo, Terkimbi B; Hyacinth, Hyacinth I (2012. ) Maternal characteristics influencing birth weight and infant weight gain in the first 6 weeks post-partum: A cross-sectional study of a post-natal clinic population.Nigerian medical journal : journal of the Nigeria Medical Association, , 53 (4 ) ,200-5 More Information

Hyacinth, Hyacinth I; Oguche, Stephen; Yilgwan, Christopher S (2012. ) Summary Description of 24 Cases of Neonatal Malaria Seen at a Tertiary Health Center in Nigeria. Iranian journal of pediatrics, , 22 (1 ) ,87-91

Driss, Adel; Wilson, Nana O; Mason, Karlene; Hyacinth, Hyacinth I; Hibbert, Jacqueline M; Serjeant, Graham R; Stiles, Jonathan K (2012. ) Elevated IL-1? and CXCL10 serum levels occur in patients with homozygous sickle cell disease and a history of acute splenic sequestration.Disease markers, , 32 (5 ) ,295-300 More Information

Hyacinth, Hyacinth I; Adekeye, Oluwatoyosi A; Ibeh, Joy N; Osoba, Tolulope (2012. ) Cervical cancer and pap smear awareness and utilization of pap smear test among Federal civil servants in North Central Nigeria.PloS one, , 7 (10 ) ,e46583 More Information

Adekeye, Oluwatoyosi A; Heiman, Harry J; Onyeabor, Onyekachi S; Hyacinth, Hyacinth I (2012. ) The new invincibles: HIV screening among older adults in the U.S.PloS one, , 7 (8 ) ,e43618 More Information

Yilgwan, Christopher S; Hyacinth, Hyacinth I; Oguche, Stephen Factors associated with decreased survival from neonatal malaria infection in Jos, North Central Nigeria. Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria, , 20 (3 ) ,349-54

Bode-Thomas, F; Hyacinth, H I; Ogunkunle, O; Omotoso, A (2011. ) Myocardial ischaemia in sickle cell anaemia: evaluation using a new scoring system.Annals of tropical paediatrics, , 31 (1 ) ,67-74 More Information

Bode-Thomas, F; Hyacinth, Ih; Yilgwan, Cs (2010. ) Co-existence of Ventricular Septal Defect and Bronchial Asthma in Two Nigerian Children.Clinical medicine insights. Case reports, , 3 ,5-8 More Information

Hyacinth, H I; Gee, B E; Hibbert, J M (2010. ) The Role of Nutrition in Sickle Cell Disease.Nutrition and metabolic insights, , 3 ,57-67 More Information

Hyacinth, Hyacinth I; Franceschini, Nora; Seals, Samantha R; Irvin, Marguerite R; Chaudhary, Ninad; Naik, Rakhi P; Alonso, Alvaro; Carty, Cara L; Burke, Gregory L; Zakai, Neil A; Winkler, Cheryl A; David, Victor A; Kopp, Jeffrey B; Judd, Suzanne E; Adams, Robert J; Gee, Beatrice E; Longstreth, W T; Egede, Leonard; Lackland, Daniel T; Greenberg, Charles S; Taylor, Herman; Manson, JoAnn E; Key, Nigel S; Derebail, Vimal K; Kshirsagar, Abhijit V; Folsom, Aaron R; Konety, Suma H; Howard, Virginia; Allison, Matthew; Wilson, James G; Correa, Adolfo; Zhi, Degui; Arnett, Donna K; Howard, George; Reiner, Alexander P; Cushman, Mary; Safford, Monika M (2021. ) Association of Sickle Cell Trait With Incidence of Coronary Heart Disease Among African American Individuals.JAMA network open, , 4 (1 ) ,e2030435 More Information

Nartey, Eunice Berko; Spector, Jonathan; Adu-Afarwuah, Seth; Jones, Catherine L; Jackson, Alan; Ohemeng, Agartha; Shah, Rajiv; Koryo-Dabrah, Alice; Kuma, Amma Benneh-Akwasi; Hyacinth, Hyacinth I; Steiner-Asiedu, Matilda (2021. ) Nutritional perspectives on sickle cell disease in Africa: a systematic review.BMC nutrition, , 7 (1 ) ,9 More Information