
Hyacinth Idu Hyacinth, MD, PHD, MPH, FAHA
Professor
MD, PhD, MPH, FAHA
Medical Sciences Building
7210
COM Neu Cognitive - 0525
Education
MD: University of Jos Jos, Nigeria, 2007 (Faculty of Medicine Sciences )
Residency: Jos University Teaching Hospital Jos, Nigeria, 2008
MPH: University of Liverpool Liverpool, United Kingdom, 2012
Post-Doctoral Fellow: Morehouse School of Medicine Atlanta, GA, 2012 (Genomics and Hemoglobinopathies)
Post-Doctoral Scholar: Medical University of South Carolina Charleston, SC, 2014 (Stroke and Neuroscience)
Post-Doctoral Fellow: Emory University School of Medicine Atlanta, GA, 2014 (Bone Marrow Transplantation)
PhD: Walden University Minneapolis, Minnesota, 2015
FAHA: American Heart/Stroke Association 2025
Research and Practice Interests
Broadly, my research is focused on understanding the biological basis for disparity in stroke, cognitive impairment and dementia. Specifically, my research has and is examining the role of the sickle cell mutation and other genetic variants on the incidence and prevalence of cerebral macro and microvascular pathologies in individuals of African ancestry. In addition, we also seek to define the mechanisms by which genetic variation in populations, results in differential risk, susceptibility and/or progression of cerebrovascular diseases (stroke, cognitive impairment and dementia)
Positions and Work Experience
11-01-2014 -05-31-2017 Instructor, Emory University School of Medicine, Atlanta, GA
06-01-2017 -01-31-2021 Assistant Professor, Emory University School of Medicine, Atlanta, GA
02-01-2021 - Associate Professor and Dorothy Woods Whitaker and D. Elizabeth Price Chair in Brain Health, University of Cincinnati, Cincinnati, OH
09-01-2023 - Professor and Dorothy Woods Whitaker and D. Elizabeth Price Chair in Brain Health, University of Cincinnati, Department of Neurology and Rehabilitation Medicine
Research Support
Grant: #R01HL138423 Investigators:Hyacinth, Hyacinth 07-01-2021 -06-30-2022 National Heart, Lung and Blood Institute Mechanism of cerebral vaculopathy and stroke in sickle cell disease Role:PI 405,000 Active Type:Grant Level:National
Grant: #R01HL138423 Investigators:Hyacinth, Hyacinth 07-01-2021 -06-30-2022 National Institute on Aging and National Heart, Lung and Blood Institute The impact of the combined presence of sickle cell mutation and AD/ADRD gene variants on development of cognitive deficits and racial disparity in AD/ADRD Role:PI 405,000.00 Active Type:Grant
Grant: #R01HL156024 07-01-2021 -11-30-2025 National Heart, Lung and Blood Institute Minocycline as a potential therapy for neuroinflammation and cognitive deficit in sickle cell disease Role:PI 286061.00 Active Level:Federal
Grant: #R01AG072592 09-15-2021 -05-31-2026 National Institute on Aging Cerebral small vessel disease burden and racial disparity in vascular cognitive impairment and Alzheimer's disease and its related dementias (transfer application) Role:PI 1505134.00 Awarded Level:Federal
Grant: #R01HL156024 Investigators:Hyacinth, Hyacinth; Niu, Liang 07-01-2021 -11-30-2025 National Heart, Lung and Blood Institute Minocycline as a potential therapy for neuroinflammation and cognitive deficit in sickle cell disease Role:PI 918007.00 Active Level:Federal
Grant: #sub / R01NS017950 Investigators:Hyacinth, Hyacinth 09-09-2023 -08-31-2028 Boston University Precursors of Stroke Incidence and Prognosis Role:PI 115820.00 Hold Level:Higher Education
Grant: #1R21AG089843-01 Investigators:Bartolacci, Caterina; Hyacinth, Hyacinth I. 07-01-2024 -06-30-2026 National Institute on Aging Interaction of sickle cell trait with human apolipoprotein E epsilon4: Impact on brain structure, brain lipidomics, neuroinflammation and cognitive deficit Role:PI 243000.00 Hold Level:Federal
Grant: #246368/R01AG089361 Investigators:Hyacinth, Hyacinth I. 09-15-2024 -07-31-2029 Massachusetts General Hospital Gut microbiome-related metabolites and cognitive impairment Role:PI 40500.00 Hold Level:Non Profit
Grant: #tba, 2RF1NS041588-22A1 Investigators:Flaherty, Matthew; Hyacinth, Hyacinth I.; Kissela, Brett; Robinson, David; Sawyer, Russell; Stanton, Robert 09-17-2024 -08-31-2026 National Institute of Neurological Disorders and Stroke Understanding Cohort Effects on Stroke, VCID, and Cognition After Major Epidemiologic Transitions Role:Collaborator 582232.00 Hold Level:Federal
Publications
Peer Reviewed Publications
Chen, Nemin; Caruso, Christina; Alonso, Alvaro; Derebail, Vimal K; Kshirsagar, Abhijit V; Sharrett, A Richey; Key, Nigel S; Gottesman, Rebecca F; Grove, Megan L; Bressler, Jan; Boerwinkle, Eric; Windham, B Gwen; Mosley, Thomas H; Hyacinth, Hyacinth I (2020). Corrigendum to 'Association of sickle cell trait with measures of cognitive function and dementia in African Americans' eNeurologicalSci, Vol. 16 (2019), 100,201. eNeurologicalSci, 21, 100281More Information
Hardy, Raven A; Rached, Noor Abi; Jones, Jayre A; Archer, David R; Hyacinth, Hyacinth I (2020). Role of age and neuroinflammation in the mechanism of cognitive deficits in sickle cell disease. Experimental biology and medicine (Maywood, N.J.), 1535370220958011More Information
Keene, Keith L; Hyacinth, Hyacinth I; Bis, Joshua C; Kittner, Steven J; Mitchell, Braxton D; Cheng, Yu-Ching; Pare, Guillaume; Chong, Michael; O'Donnell, Martin; Meschia, James F; Chen, Wei-Min; Sale, Michèle M; Rich, Stephen S; Nalls, Mike A; Zonderman, Alan B; Evans, Michele K; Wilson, James G; Correa, Adolfo; Markus, Hugh S; Traylor, Matthew; Lewis, Cathryn M; Carty, Cara L; Reiner, Alexander; Haessler, Jeff; Langefeld, Carl D; Gottesman, Rebecca; Mosley, Thomas H; Woo, Daniel; Yaffe, Kristine; Liu, YongMei; Longstreth, William T; Psaty, Bruce M; Kooperberg, Charles; Lange, Leslie A; Sacco, Ralph; Rundek, Tatjana; Lee, Jin-Moo; Cruchaga, Carlos; Furie, Karen L; Arnett, Donna K; Benavente, Oscar R; Grewal, Raji P; Peddareddygari, Leema Reddy; Dichgans, Martin; Malik, Rainer; Worrall, Bradford B; Fornage, Myriam (2020). Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke. Stroke, 51 (8) , 2454-2463More Information
Holshouser, Steven; Cafiero, Rebecca; Robinson, Mayra; Kirkpatrick, Joy; Casero, Robert A; Hyacinth, Hyacinth I; Woster, Patrick M (2020). Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease. ACS omega, 5 (24) , 14750-14758More Information
Hyacinth, Hyacinth I; Idris, Ibrahim M (2020). Cognitive deficit in sickle cell disease: Is hydroxyurea part of the story?. British journal of haematology, 189 (6) , 1014-1015More Information
Chen, Nemin; Caruso, Christina; Alonso, Alvaro; Derebail, Vimal K; Kshirsagar, Abhijit V; Sharrett, A Richey; Key, Nigel S; Gottesman, Rebecca F; Grove, Megan L; Bressler, Jan; Boerwinkle, Eric; Windham, B Gwen; Mosley, Thomas H; Hyacinth, Hyacinth I (2019). Association of sickle cell trait with measures of cognitive function and dementia in African Americans. eNeurologicalSci, 16, 100201More Information
Malik, Rainer; Chauhan, Ganesh; Traylor, Matthew; Sargurupremraj, Muralidharan; Okada, Yukinori; Mishra, Aniket; Rutten-Jacobs, Loes; Giese, Anne-Katrin; van der Laan, Sander W; Gretarsdottir, Solveig; Anderson, Christopher D; Chong, Michael; Adams, Hieab H H; Ago, Tetsuro; Almgren, Peter; Amouyel, Philippe; Ay, Hakan; Bartz, Traci M; Benavente, Oscar R; Bevan, Steve; Boncoraglio, Giorgio B; Brown, Robert D; Butterworth, Adam S; Carrera, Caty; Carty, Cara L; Chasman, Daniel I; Chen, Wei-Min; Cole, John W; Correa, Adolfo; Cotlarciuc, Ioana; Cruchaga, Carlos; Danesh, John; de Bakker, Paul I W; DeStefano, Anita L; den Hoed, Marcel; Duan, Qing; Engelter, Stefan T; Falcone, Guido J; Gottesman, Rebecca F; Grewal, Raji P; Gudnason, Vilmundur; Gustafsson, Stefan; Haessler, Jeffrey; Harris, Tamara B; Hassan, Ahamad; Havulinna, Aki S; Heckbert, Susan R; Holliday, Elizabeth G; Howard, George; Hsu, Fang-Chi; Hyacinth, Hyacinth I; Ikram, M Arfan; Ingelsson, Erik; Irvin, Marguerite R; Jian, Xueqiu; Jiménez-Conde, Jordi; Johnson, Julie A; Jukema, J Wouter; Kanai, Masahiro; Keene, Keith L; Kissela, Brett M; Kleindorfer, Dawn O; Kooperberg, Charles; Kubo, Michiaki; Lange, Leslie A; Langefeld, Carl D; Langenberg, Claudia; Launer, Lenore J; Lee, Jin-Moo; Lemmens, Robin; Leys, Didier; Lewis, Cathryn M; Lin, Wei-Yu; Lindgren, Arne G; Lorentzen, Erik; Magnusson, Patrik K; Maguire, Jane; Manichaikul, Ani; McArdle, Patrick F; Meschia, James F; Mitchell, Braxton D; Mosley, Thomas H; Nalls, Michael A; Ninomiya, Toshiharu; O'Donnell, Martin J; Psaty, Bruce M; Pulit, Sara L; Rannikmäe, Kristiina; Reiner, Alexander P; Rexrode, Kathryn M; Rice, Kenneth; Rich, Stephen S; Ridker, Paul M; Rost, Natalia S; Rothwell, Peter M; Rotter, Jerome I; Rundek, Tatjana; Sacco, Ralph L; Sakaue, Saori; Sale, Michele M; Salomaa, Veikko; Sapkota, Bishwa R; Schmidt, Reinhold; Schmidt, Carsten O; Schminke, Ulf; Sharma, Pankaj; Slowik, Agnieszka; Sudlow, Cathie L M; Tanislav, Christian; Tatlisumak, Turgut; Taylor, Kent D; Thijs, Vincent N S; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tiedt, Steffen; Trompet, Stella; Tzourio, Christophe; van Duijn, Cornelia M; Walters, Matthew; Wareham, Nicholas J; Wassertheil-Smoller, Sylvia; Wilson, James G; Wiggins, Kerri L; Yang, Qiong; Yusuf, Salim ; Bis, Joshua C; Pastinen, Tomi; Ruusalepp, Arno; Schadt, Eric E; Koplev, Simon; Björkegren, Johan L M; Codoni, Veronica; Civelek, Mete; Smith, Nicholas L; Trégouët, David A; Christophersen, Ingrid E; Roselli, Carolina; Lubitz, Steven A; Ellinor, Patrick T; Tai, E Shyong; Kooner, Jaspal S; Kato, Norihiro; He, Jiang; van der Harst, Pim; Elliott, Paul; Chambers, John C; Takeuchi, Fumihiko; Johnson, Andrew D ; Sanghera, Dharambir K; Melander, Olle; Jern, Christina; Strbian, Daniel; Fernandez-Cadenas, Israel; Longstreth, W T; Rolfs, Arndt; Hata, Jun; Woo, Daniel; Rosand, Jonathan; Pare, Guillaume; Hopewell, Jemma C; Saleheen, Danish; Stefansson, Kari; Worrall, Bradford B; Kittner, Steven J; Seshadri, Sudha; Fornage, Myriam; Markus, Hugh S; Howson, Joanna M M; Kamatani, Yoichiro; Debette, Stephanie; Dichgans, Martin (2019). Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature genetics, 51 (7) , 1192-1193More Information
Cahill, Christina R; Leach, Justin M; McClure, Leslie A; Irvin, Marguerite Ryan; Zakai, Neil A; Naik, Rakhi; Unverzagt, Frederick; Wadley, Virginia G; Hyacinth, Hyacinth I; Manly, Jennifer; Judd, Suzanne E; Winkler, Cheryl; Cushman, MarySickle cell trait and risk of cognitive impairment in African-Americans: The REGARDS cohort. EClinicalMedicine, 11, 27-33More Information
Larsson, Susanna C; Traylor, Matthew; Burgess, Stephen; Boncoraglio, Giorgio B; Jern, Christina; Michaëlsson, Karl; Markus, Hugh S (2019). Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study. Neurology, 92 (9) , e944-e950More Information
Hyacinth, Hyacinth I; Sugihara, Courtney L; Spencer, Thomas L; Archer, David R; Shih, Andy Y (2019). Higher prevalence of spontaneous cerebral vasculopathy and cerebral infarcts in a mouse model of sickle cell disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 39 (2) , 342-351More Information
Chauhan, Ganesh; Adams, Hieab H H; Satizabal, Claudia L; Bis, Joshua C; Teumer, Alexander; Sargurupremraj, Muralidharan; Hofer, Edith; Trompet, Stella; Hilal, Saima; Smith, Albert Vernon; Jian, Xueqiu; Malik, Rainer; Traylor, Matthew; Pulit, Sara L; Amouyel, Philippe; Mazoyer, Bernard; Zhu, Yi-Cheng; Kaffashian, Sara; Schilling, Sabrina; Beecham, Gary W; Montine, Thomas J; Schellenberg, Gerard D; Kjartansson, Olafur; Guðnason, Vilmundur; Knopman, David S; Griswold, Michael E; Windham, B Gwen; Gottesman, Rebecca F; Mosley, Thomas H; Schmidt, Reinhold; Saba, Yasaman; Schmidt, Helena; Takeuchi, Fumihiko; Yamaguchi, Shuhei; Nabika, Toru; Kato, Norihiro; Rajan, Kumar B; Aggarwal, Neelum T; De Jager, Philip L; Evans, Denis A; Psaty, Bruce M; Rotter, Jerome I; Rice, Kenneth; Lopez, Oscar L; Liao, Jiemin; Chen, Christopher; Cheng, Ching-Yu; Wong, Tien Y; Ikram, Mohammad K; van der Lee, Sven J; Amin, Najaf; Chouraki, Vincent; DeStefano, Anita L; Aparicio, Hugo J; Romero, Jose R; Maillard, Pauline; DeCarli, Charles; Wardlaw, Joanna M; Hernández, Maria Del C Valdés; Luciano, Michelle; Liewald, David; Deary, Ian J; Starr, John M; Bastin, Mark E; Muñoz Maniega, Susana; Slagboom, P Eline; Beekman, Marian; Deelen, Joris; Uh, Hae-Won; Lemmens, Robin; Brodaty, Henry; Wright, Margaret J; Ames, David; Boncoraglio, Giorgio B; Hopewell, Jemma C; Beecham, Ashley H; Blanton, Susan H; Wright, Clinton B; Sacco, Ralph L; Wen, Wei; Thalamuthu, Anbupalam; Armstrong, Nicola J; Chong, Elizabeth; Schofield, Peter R; Kwok, John B; van der Grond, Jeroen; Stott, David J; Ford, Ian; Jukema, J Wouter; Vernooij, Meike W; Hofman, Albert; Uitterlinden, André G; van der Lugt, Aad; Wittfeld, Katharina; Grabe, Hans J; Hosten, Norbert; von Sarnowski, Bettina; Völker, Uwe; Levi, Christopher; Jimenez-Conde, Jordi; Sharma, Pankaj; Sudlow, Cathie L M; Rosand, Jonathan; Woo, Daniel; Cole, John W; Meschia, James F; Slowik, Agnieszka; Thijs, Vincent; Lindgren, Arne; Melander, Olle; Grewal, Raji P; Rundek, Tatjana; Rexrode, Kathy; Rothwell, Peter M; Arnett, Donna K; Jern, Christina; Johnson, Julie A; Benavente, Oscar R; Wasssertheil-Smoller, Sylvia; Lee, Jin-Moo; Wong, Quenna; Mitchell, Braxton D; Rich, Stephen S; McArdle, Patrick F; Geerlings, Mirjam I; van der Graaf, Yolanda; de Bakker, Paul I W; Asselbergs, Folkert W; Srikanth, Velandai; Thomson, Russell; McWhirter, Rebekah; Moran, Chris; Callisaya, Michele; Phan, Thanh; Rutten-Jacobs, Loes C A; Bevan, Steve; Tzourio, Christophe; Mather, Karen A; Sachdev, Perminder S; van Duijn, Cornelia M; Worrall, Bradford B; Dichgans, Martin; Kittner, Steven J; Markus, Hugh S; Ikram, Mohammad A; Fornage, Myriam; Launer, Lenore J; Seshadri, Sudha; Longstreth, W T; Debette, Stéphanie (2019). Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. NeurologyMore Information
Douce, Daniel R; Soliman, Elsayed Z; Naik, Rakhi; Hyacinth, Hyacinth I; Cushman, Mary; Winkler, Cheryl A; Howard, George; Lange, Ethan M; Lange, Leslie A; Irvin, Marguerite R; Zakai, Neil AAssociation of sickle cell trait with atrial fibrillation: The REGARDS cohort. Journal of electrocardiology, 55, 1-5More Information
Franceschini, Nora; Giambartolomei, Claudia; de Vries, Paul S; Finan, Chris; Bis, Joshua C; Huntley, Rachael P; Lovering, Ruth C; Tajuddin, Salman M; Winkler, Thomas W; Graff, Misa; Kavousi, Maryam; Dale, Caroline; Smith, Albert V; Hofer, Edith; van Leeuwen, Elisabeth M; Nolte, Ilja M; Lu, Lingyi; Scholz, Markus; Sargurupremraj, Muralidharan; Pitkänen, Niina; Franzén, Oscar; Joshi, Peter K; Noordam, Raymond; Marioni, Riccardo E; Hwang, Shih-Jen; Musani, Solomon K; Schminke, Ulf; Palmas, Walter; Isaacs, Aaron; Correa, Adolfo; Zonderman, Alan B; Hofman, Albert; Teumer, Alexander; Cox, Amanda J; Uitterlinden, André G; Wong, Andrew; Smit, Andries J; Newman, Anne B; Britton, Annie; Ruusalepp, Arno; Sennblad, Bengt; Hedblad, Bo; Pasaniuc, Bogdan; Penninx, Brenda W; Langefeld, Carl D; Wassel, Christina L; Tzourio, Christophe; Fava, Cristiano; Baldassarre, Damiano; O'Leary, Daniel H; Teupser, Daniel; Kuh, Diana; Tremoli, Elena; Mannarino, Elmo; Grossi, Enzo; Boerwinkle, Eric; Schadt, Eric E; Ingelsson, Erik; Veglia, Fabrizio; Rivadeneira, Fernando; Beutner, Frank; Chauhan, Ganesh; Heiss, Gerardo; Snieder, Harold; Campbell, Harry; Völzke, Henry; Markus, Hugh S; Deary, Ian J; Jukema, J Wouter; de Graaf, Jacqueline; Price, Jacqueline; Pott, Janne; Hopewell, Jemma C; Liang, Jingjing; Thiery, Joachim; Engmann, Jorgen; Gertow, Karl; Rice, Kenneth; Taylor, Kent D; Dhana, Klodian; Kiemeney, Lambertus A L M; Lind, Lars; Raffield, Laura M; Launer, Lenore J; Holdt, Lesca M; Dörr, Marcus; Dichgans, Martin; Traylor, Matthew; Sitzer, Matthias; Kumari, Meena; Kivimaki, Mika; Nalls, Mike A; Melander, Olle; Raitakari, Olli; Franco, Oscar H; Rueda-Ochoa, Oscar L; Roussos, Panos; Whincup, Peter H; Amouyel, Philippe; Giral, Philippe; Anugu, Pramod; Wong, Quenna; Malik, Rainer; Rauramaa, Rainer; Burkhardt, Ralph; Hardy, Rebecca; Schmidt, Reinhold; de Mutsert, Renée; Morris, Richard W; Strawbridge, Rona J; Wannamethee, S Goya; Hägg, Sara; Shah, Sonia; McLachlan, Stela; Trompet, Stella; Seshadri, Sudha; Kurl, Sudhir; Heckbert, Susan R; Ring, Susan; Harris, Tamara B; Lehtimäki, Terho; Galesloot, Tessel E; Shah, Tina; de Faire, Ulf; Plagnol, Vincent; Rosamond, Wayne D; Post, Wendy; Zhu, Xiaofeng; Zhang, Xiaoling; Guo, Xiuqing; Saba, Yasaman ; Dehghan, Abbas; Seldenrijk, Adrie; Morrison, Alanna C; Hamsten, Anders; Psaty, Bruce M; van Duijn, Cornelia M; Lawlor, Deborah A; Mook-Kanamori, Dennis O; Bowden, Donald W; Schmidt, Helena; Wilson, James F; Wilson, James G; Rotter, Jerome I; Wardlaw, Joanna M; Deanfield, John; Halcox, Julian; Lyytikäinen, Leo-Pekka; Loeffler, Markus; Evans, Michele K; Debette, Stéphanie; Humphries, Steve E; Völker, Uwe; Gudnason, Vilmundur; Hingorani, Aroon D; Björkegren, Johan L M; Casas, Juan P; O'Donnell, Christopher J (2018). GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nature communications, 9 (1) , 5141More Information
Hyacinth, Hyacinth I (2018). The injured brain might need more fat!. EBioMedicine, 33, 12-13More Information
Hyacinth, Hyacinth I; Carty, Cara L; Seals, Samantha R; Irvin, Marguerite R; Naik, Rakhi P; Burke, Gregory L; Zakai, Neil A; Wilson, James G; Franceschini, Nora; Winkler, Cheryl A; David, Victor A; Kopp, Jeffrey B; Judd, Suzanne E; Adams, Robert J; Longstreth, W T; Egede, Leonard; Lackland, Daniel T; Taylor, Herman; Manson, JoAnn E; Howard, Virginia; Allison, Matthew; Gee, Beatrice E; Correa, Adolfo; Safford, Monika M; Arnett, Donna K; Howard, George; Reiner, Alexander P; Cushman, Mary (2018). Association of Sickle Cell Trait With Ischemic Stroke Among African Americans: A Meta-analysis. JAMA neurology, 75 (7) , 802-807More Information
Gutiérrez, Orlando M; Irvin, Marguerite R; Chaudhary, Ninad S; Cushman, Mary; Zakai, Neil A; David, Victor A; Limou, Sophie; Pamir, Nathalie; Reiner, Alex P; Naik, Rakhi P; Sale, Michele M; Safford, Monika M; Hyacinth, Hyacinth I; Judd, Suzanne E; Kopp, Jeffrey B; Winkler, Cheryl A (2018). APOL1 Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults. Circulation. Genomic and precision medicine, 11 (6) , e002098More Information
Hyacinth, Hyacinth I (2018). Sickle-cell anaemia needs more food?. The Lancet. Haematology, 5 (4) , e130-e131More Information
Malik, Rainer; Chauhan, Ganesh; Traylor, Matthew; Sargurupremraj, Muralidharan; Okada, Yukinori; Mishra, Aniket; Rutten-Jacobs, Loes; Giese, Anne-Katrin; van der Laan, Sander W; Gretarsdottir, Solveig; Anderson, Christopher D; Chong, Michael; Adams, Hieab H H; Ago, Tetsuro; Almgren, Peter; Amouyel, Philippe; Ay, Hakan; Bartz, Traci M; Benavente, Oscar R; Bevan, Steve; Boncoraglio, Giorgio B; Brown, Robert D; Butterworth, Adam S; Carrera, Caty; Carty, Cara L; Chasman, Daniel I; Chen, Wei-Min; Cole, John W; Correa, Adolfo; Cotlarciuc, Ioana; Cruchaga, Carlos; Danesh, John; de Bakker, Paul I W; DeStefano, Anita L; den Hoed, Marcel; Duan, Qing; Engelter, Stefan T; Falcone, Guido J; Gottesman, Rebecca F; Grewal, Raji P; Gudnason, Vilmundur; Gustafsson, Stefan; Haessler, Jeffrey; Harris, Tamara B; Hassan, Ahamad; Havulinna, Aki S; Heckbert, Susan R; Holliday, Elizabeth G; Howard, George; Hsu, Fang-Chi; Hyacinth, Hyacinth I; Ikram, M Arfan; Ingelsson, Erik; Irvin, Marguerite R; Jian, Xueqiu; Jiménez-Conde, Jordi; Johnson, Julie A; Jukema, J Wouter; Kanai, Masahiro; Keene, Keith L; Kissela, Brett M; Kleindorfer, Dawn O; Kooperberg, Charles; Kubo, Michiaki; Lange, Leslie A; Langefeld, Carl D; Langenberg, Claudia; Launer, Lenore J; Lee, Jin-Moo; Lemmens, Robin; Leys, Didier; Lewis, Cathryn M; Lin, Wei-Yu; Lindgren, Arne G; Lorentzen, Erik; Magnusson, Patrik K; Maguire, Jane; Manichaikul, Ani; McArdle, Patrick F; Meschia, James F; Mitchell, Braxton D; Mosley, Thomas H; Nalls, Michael A; Ninomiya, Toshiharu; O'Donnell, Martin J; Psaty, Bruce M; Pulit, Sara L; Rannikmäe, Kristiina; Reiner, Alexander P; Rexrode, Kathryn M; Rice, Kenneth; Rich, Stephen S; Ridker, Paul M; Rost, Natalia S; Rothwell, Peter M; Rotter, Jerome I; Rundek, Tatjana; Sacco, Ralph L; Sakaue, Saori; Sale, Michele M; Salomaa, Veikko; Sapkota, Bishwa R; Schmidt, Reinhold; Schmidt, Carsten O; Schminke, Ulf; Sharma, Pankaj; Slowik, Agnieszka; Sudlow, Cathie L M; Tanislav, Christian; Tatlisumak, Turgut; Taylor, Kent D; Thijs, Vincent N S; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tiedt, Steffen; Trompet, Stella; Tzourio, Christophe; van Duijn, Cornelia M; Walters, Matthew; Wareham, Nicholas J; Wassertheil-Smoller, Sylvia; Wilson, James G; Wiggins, Kerri L; Yang, Qiong; Yusuf, Salim ; Bis, Joshua C; Pastinen, Tomi; Ruusalepp, Arno; Schadt, Eric E; Koplev, Simon; Björkegren, Johan L M; Codoni, Veronica; Civelek, Mete; Smith, Nicholas L; Trégouët, David A; Christophersen, Ingrid E; Roselli, Carolina; Lubitz, Steven A; Ellinor, Patrick T; Tai, E Shyong; Kooner, Jaspal S; Kato, Norihiro; He, Jiang; van der Harst, Pim; Elliott, Paul; Chambers, John C; Takeuchi, Fumihiko; Johnson, Andrew D ; Sanghera, Dharambir K; Melander, Olle; Jern, Christina; Strbian, Daniel; Fernandez-Cadenas, Israel; Longstreth, W T; Rolfs, Arndt; Hata, Jun; Woo, Daniel; Rosand, Jonathan; Pare, Guillaume; Hopewell, Jemma C; Saleheen, Danish; Stefansson, Kari; Worrall, Bradford B; Kittner, Steven J; Seshadri, Sudha; Fornage, Myriam; Markus, Hugh S; Howson, Joanna M M; Kamatani, Yoichiro; Debette, Stephanie; Dichgans, Martin (2018). Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature genetics, 50 (4) , 524-537More Information
Hartmann, David A; Hyacinth, Hyacinth I; Liao, Francesca-Fang; Shih, Andy Y (2018). Does pathology of small venules contribute to cerebral microinfarcts and dementia?. Journal of neurochemistry, 144 (5) , 517-526More Information
Shih, Andy Y; Hyacinth, Hyacinth I; Hartmann, David A; van Veluw, Susanne J (2018). Rodent Models of Cerebral Microinfarct and Microhemorrhage. Stroke, 49 (3) , 803-810More Information
Coleman, Elisheva R; Moudgal, Rohitha; Lang, Kathryn; Hyacinth, Hyacinth I; Awosika, Oluwole O; Kissela, Brett M; Feng, Wuwei (2017). Early Rehabilitation After Stroke: a Narrative Review. Current atherosclerosis reports, 19 (12) , 59More Information
Wright, Racquel J; Lee, Ken S; Hyacinth, Hyacinth I; Hibbert, Jacqueline M; Reid, Marvin E; Wheatley, Andrew O; Asemota, Helen N (2017). An Investigation of the Antioxidant Capacity in Extracts from Moringa oleifera Plants Grown in Jamaica. Plants (Basel, Switzerland), 6 (4) More Information
Bello, Natalie A; Hyacinth, Hyacinth I; Roetker, Nicholas S; Seals, Samantha R; Naik, Rakhi P; Derebail, Vimal K; Kshirsagar, Abhijit V; Key, Nigel S; Wilson, James G; Correa, Adolfo; Adams, Robert J; Egede, Leonard D; Longstreth, W T; Choudhary, Gaurav; Gee, Beatrice E; Hughes, Austin L; Shah, Amil M; Manson, JoAnn E; Allison, Matthew; Burke, Gregory L; Folsom, Aaron R; Carty, Cara L; Reiner, Alexander P; Solomon, Scott D; Konety, Suma H (2017). Sickle cell trait is not associated with an increased risk of heart failure or abnormalities of cardiac structure and function. Blood, 129 (6) , 799-801More Information
Hyacinth, Hyacinth I; Adams, Robert J; Greenberg, Charles S; Voeks, Jenifer H; Hill, Allyson; Hibbert, Jacqueline M; Gee, Beatrice E (2015). Effect of Chronic Blood Transfusion on Biomarkers of Coagulation Activation and Thrombin Generation in Sickle Cell Patients at Risk for Stroke. PloS one, 10 (8) , e0134193More Information
Capers, Patrice L; Hyacinth, Hyacinth I; Cue, Shayla; Chappa, Prasanthi; Vikulina, Tatyana; Roser-Page, Susanne; Weitzmann, M Neale; Archer, David R; Newman, Gale W; Quarshie, Alexander; Stiles, Jonathan K; Hibbert, Jacqueline M (2015). Body composition and grip strength are improved in transgenic sickle mice fed a high-protein diet. Journal of nutritional science, 4, e6More Information
Naik, Rakhi P; Derebail, Vimal K; Grams, Morgan E; Franceschini, Nora; Auer, Paul L; Peloso, Gina M; Young, Bessie A; Lettre, Guillaume; Peralta, Carmen A; Katz, Ronit; Hyacinth, Hyacinth I; Quarells, Rakale C; Grove, Megan L; Bick, Alexander G; Fontanillas, Pierre; Rich, Stephen S; Smith, Joshua D; Boerwinkle, Eric; Rosamond, Wayne D; Ito, Kaoru; Lanzkron, Sophie; Coresh, Josef; Correa, Adolfo; Sarto, Gloria E; Key, Nigel S; Jacobs, David R; Kathiresan, Sekar; Bibbins-Domingo, Kirsten; Kshirsagar, Abhijit V; Wilson, James G; Reiner, Alexander P (2014). Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans. JAMA, 312 (20) , 2115-25More Information
Malek, Angela M; Adams, Robert J; Debenham, Ellen; Boan, Andrea D; Kazley, Abby S; Hyacinth, Hyacinth I; Voeks, Jenifer H; Lackland, Daniel T (2014). Patient awareness and perception of stroke symptoms and the use of 911. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 23 (9) , 2362-71More Information
Manci, Elizabeth Ann; Hyacinth, Hyacinth I; Capers, Patrice L; Archer, David R; Pitts, Sydney; Ghosh, Samit; Patrickson, John; Titford, Michael E; Ofori-Acquah, Solomon F; Hibbert, Jacqueline M (2014). High protein diet attenuates histopathologic organ damage and vascular leakage in transgenic murine model of sickle cell anemia. Experimental biology and medicine (Maywood, N.J.), 239 (8) , 966-974More Information
Hyacinth, Hyacinth I; Adams, Robert J; Voeks, Jenifer H; Hibbert, Jacqueline M; Gee, Beatrice E (2014). Frequent red cell transfusions reduced vascular endothelial activation and thrombogenicity in children with sickle cell anemia and high stroke risk. American journal of hematology, 89 (1) , 47-51More Information
Hyacinth, Hyacinth I; Capers, Patrice L; Archer, David R; Hibbert, Jacqueline M (2014). TNF-?, IFN-?, IL-10, and IL-4 levels were elevated in a murine model of human sickle cell anemia maintained on a high protein/calorie diet. Experimental biology and medicine (Maywood, N.J.), 239 (1) , 65-70More Information
Ellis, Charles; Hyacinth, Hyacinth I; Beckett, Jamie; Feng, Wuwei; Chimowitz, Marc; Ovbiagele, Bruce; Lackland, Dan; Adams, Robert (2014). Racial/Ethnic differences in poststroke rehabilitation outcomes. Stroke research and treatment, 2014, 950746More Information
Hyacinth, Hyacinth I; Adekeye, Oluwatoyosi A; Yilgwan, Christopher S (2013). Malnutrition in Sickle Cell Anemia: Implications for Infection, Growth, and Maturation. Journal of social, behavioral and health sciences, 7 (1) More Information
Hyacinth, Hyacinth I; Gee, Beatrice E; Adamkiewicz, Thomas V; Adams, Robert J; Kutlar, Abdullah; Stiles, Jonathan K; Hibbert, Jacqueline M (2012). Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemia. Cytokine, 60 (1) , 302-8More Information
Yilgwan, Christopher S; Utoo, Terkimbi B; Hyacinth, Hyacinth I (2012). Maternal characteristics influencing birth weight and infant weight gain in the first 6 weeks post-partum: A cross-sectional study of a post-natal clinic population. Nigerian medical journal : journal of the Nigeria Medical Association, 53 (4) , 200-5More Information
Hyacinth, Hyacinth I; Oguche, Stephen; Yilgwan, Christopher S (2012). Summary Description of 24 Cases of Neonatal Malaria Seen at a Tertiary Health Center in Nigeria. Iranian journal of pediatrics, 22 (1) , 87-91
Driss, Adel; Wilson, Nana O; Mason, Karlene; Hyacinth, Hyacinth I; Hibbert, Jacqueline M; Serjeant, Graham R; Stiles, Jonathan K (2012). Elevated IL-1? and CXCL10 serum levels occur in patients with homozygous sickle cell disease and a history of acute splenic sequestration. Disease markers, 32 (5) , 295-300More Information
Hyacinth, Hyacinth I; Adekeye, Oluwatoyosi A; Ibeh, Joy N; Osoba, Tolulope (2012). Cervical cancer and pap smear awareness and utilization of pap smear test among Federal civil servants in North Central Nigeria. PloS one, 7 (10) , e46583More Information
Adekeye, Oluwatoyosi A; Heiman, Harry J; Onyeabor, Onyekachi S; Hyacinth, Hyacinth I (2012). The new invincibles: HIV screening among older adults in the U.S. PloS one, 7 (8) , e43618More Information
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Bode-Thomas, F; Hyacinth, H I; Ogunkunle, O; Omotoso, A (2011). Myocardial ischaemia in sickle cell anaemia: evaluation using a new scoring system. Annals of tropical paediatrics, 31 (1) , 67-74More Information
Bode-Thomas, F; Hyacinth, Ih; Yilgwan, Cs (2010). Co-existence of Ventricular Septal Defect and Bronchial Asthma in Two Nigerian Children. Clinical medicine insights. Case reports, 3, 5-8More Information
Hyacinth, H I; Gee, B E; Hibbert, J M (2010). The Role of Nutrition in Sickle Cell Disease. Nutrition and metabolic insights, 3, 57-67More Information
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Nartey, Eunice Berko; Spector, Jonathan; Adu-Afarwuah, Seth; Jones, Catherine L; Jackson, Alan; Ohemeng, Agartha; Shah, Rajiv; Koryo-Dabrah, Alice; Kuma, Amma Benneh-Akwasi; Hyacinth, Hyacinth I; Steiner-Asiedu, Matilda (2021). Nutritional perspectives on sickle cell disease in Africa: a systematic review. BMC nutrition, 7 (1) , 9More Information
Idris, Ibrahim M; Botchwey, Edward A; Hyacinth, Hyacinth I (2022). Sickle cell disease as an accelerated aging syndrome. Experimental biology and medicine (Maywood, N.J.), 15353702211068522More Information
Prapiadou, Savvina; Demel, Stacie L; Hyacinth, Hyacinth I (2021). Genetic and Genomic Epidemiology of Stroke in People of African Ancestry. Genes, 12 (11) More Information
Muratoglu, Selen C; Charette, Marc F; Galis, Zorina S; Greenstein, Adam S; Daugherty, Alan; Joutel, Anne; Kozel, Beth A; Wilcock, Donna M; Collins, Emily C; Sorond, Farzaneh A; Howell, Gareth R; Hyacinth, Hyacinth I; Lloyd, Kent K C; Stenmark, Kurt R; Boehm, Manfred; Kahn, Mark L; Corriveau, Roderick; Wells, Sara; Bussey, Timothy J; Sukoff Rizzo, Stacey J; Iruela-Arispe, M Luisa (2022). Perspectives on Cognitive Phenotypes and Models of Vascular Disease. Arteriosclerosis, thrombosis, and vascular biology, 42 (7) , 831-838More Information
Sawyer, Russell P; Worrall, Bradford B; Howard, Virginia J; Crowe, Michael G; Howard, George; Hyacinth, Hyacinth I (2023). Methods of a Study to Assess the Contribution of Cerebral Small Vessel Disease and Dementia Risk Alleles to Racial Disparities in Vascular Cognitive Impairment and Dementia. Journal of the American Heart Association, e030925More Information
Gbotosho, Oluwabukola T; Li, Wei; Joiner, Clinton H; Brown, Lou Ann S; Hyacinth, Hyacinth I (2023). The inflammatory profiles of pulmonary alveolar macrophages and alveolar type 2 cells in SCD. Experimental biology and medicine (Maywood, N.J.), 15353702231157940More Information
Myserlis, Evangelos Pavlos; Georgakis, Marios K; Demel, Stacie L; Sekar, Padmini; Chung, Jaeyoon; Malik, Rainer; Hyacinth, Hyacinth I; Comeau, Mary E; Falcone, Guido J; Langefeld, Carl D; Rosand, Jonathan; Woo, Daniel; Anderson, Christopher D (2023). A Genomic Risk Score Identifies Individuals at High Risk for Intracerebral Hemorrhage. Stroke, 54 (4) , 973-982More Information
Gbotosho, Oluwabukola T; Gollamudi, Jahnavi; Hyacinth, Hyacinth I (2023). The Role of Inflammation in The Cellular and Molecular Mechanisms of Cardiopulmonary Complications of Sickle Cell Disease. Biomolecules, 13 (2) More Information
Abi Rached, Noor Mary; Gbotosho, Oluwabukola T; Archer, David R; Jones, Jayre A; Sterling, Morgan S; Hyacinth, Hyacinth I (2022). Adhesion molecules and cerebral microvascular hemodynamic abnormalities in sickle cell disease. Frontiers in neurology, 13, 976063More Information
Mishra, Aniket; Malik, Rainer; Hachiya, Tsuyoshi; Jürgenson, Tuuli; Namba, Shinichi; Posner, Daniel C; Kamanu, Frederick K; Koido, Masaru; Le Grand, Quentin; Shi, Mingyang; He, Yunye; Georgakis, Marios K; Caro, Ilana; Krebs, Kristi; Liaw, Yi-Ching; Vaura, Felix C; Lin, Kuang; Winsvold, Bendik Slagsvold; Srinivasasainagendra, Vinodh; Parodi, Livia; Bae, Hee-Joon; Chauhan, Ganesh; Chong, Michael R; Tomppo, Liisa; Akinyemi, Rufus; Roshchupkin, Gennady V; Habib, Naomi; Jee, Yon Ho; Thomassen, Jesper Qvist; Abedi, Vida; Cárcel-Márquez, Jara; Nygaard, Marianne; Leonard, Hampton L; Yang, Chaojie; Yonova-Doing, Ekaterina; Knol, Maria J; Lewis, Adam J; Judy, Renae L; Ago, Tetsuro; Amouyel, Philippe; Armstrong, Nicole D; Bakker, Mark K; Bartz, Traci M; Bennett, David A; Bis, Joshua C; Bordes, Constance; Børte, Sigrid; Cain, Anael; Ridker, Paul M; Cho, Kelly; Chen, Zhengming; Cruchaga, Carlos; Cole, John W; de Jager, Phil L; de Cid, Rafael; Endres, Matthias; Ferreira, Leslie E; Geerlings, Mirjam I; Gasca, Natalie C; Gudnason, Vilmundur; Hata, Jun; He, Jing; Heath, Alicia K; Ho, Yuk-Lam; Havulinna, Aki S; Hopewell, Jemma C; Hyacinth, Hyacinth I; Inouye, Michael; Jacob, Mina A; Jeon, Christina E; Jern, Christina; Kamouchi, Masahiro; Keene, Keith L; Kitazono, Takanari; Kittner, Steven J; Konuma, Takahiro; Kumar, Amit; Lacaze, Paul; Launer, Lenore J; Lee, Keon-Joo; Lepik, Kaido; Li, Jiang; Li, Liming; Manichaikul, Ani; Markus, Hugh S; Marston, Nicholas A; Meitinger, Thomas; Mitchell, Braxton D; Montellano, Felipe A; Morisaki, Takayuki; Mosley, Thomas H; Nalls, Mike A; Nordestgaard, Børge G; O'Donnell, Martin J; Okada, Yukinori; Onland-Moret, N Charlotte; Ovbiagele, Bruce; Peters, Annette; Psaty, Bruce M; Rich, Stephen S; Rosand, Jonathan; Sabatine, Marc S; Sacco, Ralph L; Saleheen, Danish; Sandset, Else Charlotte; Salomaa, Veikko; Sargurupremraj, Muralidharan; Sasaki, Makoto; Satizabal, Claudia L; Schmidt, Carsten O; Shimizu, Atsushi; Smith, Nicholas L; Sloane, Kelly L; Sutoh, Yoichi; Sun, Yan V; Tanno, Kozo; Tiedt, Steffen; Tatlisumak, Turgut; Torres-Aguila, Nuria P; Tiwari, Hemant K; Trégouët, David-Alexandre; Trompet, Stella; Tuladhar, Anil Man; Tybjærg-Hansen, Anne; van Vugt, Marion; Vibo, Riina; Verma, Shefali S; Wiggins, Kerri L; Wennberg, Patrik; Woo, Daniel; Wilson, Peter W F; Xu, Huichun; Yang, Qiong; Yoon, Kyungheon ; Millwood, Iona Y; Gieger, Christian; Ninomiya, Toshiharu; Grabe, Hans J; Jukema, J Wouter; Rissanen, Ina L; Strbian, Daniel; Kim, Young Jin; Chen, Pei-Hsin; Mayerhofer, Ernst; Howson, Joanna M M; Irvin, Marguerite R; Adams, Hieab; Wassertheil-Smoller, Sylvia; Christensen, Kaare; Ikram, Mohammad A; Rundek, Tatjana; Worrall, Bradford B; Lathrop, G Mark; Riaz, Moeen; Simonsick, Eleanor M; Kõrv, Janika; França, Paulo H C; Zand, Ramin; Prasad, Kameshwar; Frikke-Schmidt, Ruth; de Leeuw, Frank-Erik; Liman, Thomas; Haeusler, Karl Georg; Ruigrok, Ynte M; Heuschmann, Peter Ulrich; Longstreth, W T; Jung, Keum Ji; Bastarache, Lisa; Paré, Guillaume; Damrauer, Scott M; Chasman, Daniel I; Rotter, Jerome I; Anderson, Christopher D; Zwart, John-Anker; Niiranen, Teemu J; Fornage, Myriam; Liaw, Yung-Po; Seshadri, Sudha; Fernández-Cadenas, Israel; Walters, Robin G; Ruff, Christian T; Owolabi, Mayowa O; Huffman, Jennifer E; Milani, Lili; Kamatani, Yoichiro; Dichgans, Martin; Debette, Stephanie (2022). Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries. Nature, 612 (7938) , E7More Information
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DeVeaux, S'Dravious A; Vyshnya, Sofiya; Propsom, Katherine; Gbotosho, Oluwabukola T; Singh, Asem S; Horning, Robert Z; Sharma, Mihika; Jegga, Anil G; Niu, Liang; Botchwey, Edward A; Hyacinth, Hyacinth I (2024). Neuroinflammation underlies the development of social stress induced cognitive deficit in male sickle cell mice. Experimental biology and medicine (Maywood, N.J.), 249, 10361More Information
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Shim, Joon W; Hyacinth, Hyacinth I; Gonzalez-Perez, Oscar (2024). Editorial: Current therapeutic approaches in Alzheimer's disease: the use of a second drug with anti-amyloid-beta and beyond. Frontiers in neuroscience, 18, 1449365More Information
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