Igal Ifergan , PhD

B.S.: Université de Montréal Montréal, (Microbiology and Immunology)

M.S.: Université de Montréal Montréal, (Microbiology and Immunology)

Ph.D.: Université de Montréal Montréal, (Neuro-Immunology)

Role of the neurovascular molecule Wnt in regulating CNS inflammatory responses

- Post-Doc, Northwestern University, Chicago

- Research Assistant Professor, Northwestern University, Chicago

Grant: #PP-2008-37129 Investigators:Ifergan, Igal 08-01-2020 -07-31-2021 National Multiple Sclerosis Society Induction of Immunoregulatory Microglia by the Wnt Pathway During Neuroinflammation Role:PI 37295.00 Hold Level:Non Profit

Grant: #R35GM146890 Investigators:Ifergan, Igal 08-01-2022 -06-30-2027 National Institute of General Medical Sciences Role of the neurovascular molecule Wnt in regulating CNS inflammatory responses Role:PI 356907.00 Awarded Level:Federal

Peer Reviewed Publications

Cortez, Jessica T; Montauti, Elena; Shifrut, Eric; Gatchalian, Jovylyn; Zhang, Yusi; Shaked, Oren; Xu, Yuanming; Roth, Theodore L; Simeonov, Dimitre R; Zhang, Yana; Chen, Siqi; Li, Zhongmei; Woo, Jonathan M; Ho, Josephine; Vogel, Ian A; Prator, Grace Y; Zhang, Bin; Lee, Youjin; Sun, Zhaolin; Ifergan, Igal; Van Gool, Frédéric; Hargreaves, Diana C; Bluestone, Jeffrey A; Marson, Alexander; Fang, Deyu (2020. ) CRISPR screen in regulatory T cells reveals modulators of Foxp3.Nature, , 582 (7812 ) ,416-420 More Information

Park, Seo J; Riccio, Rachel E; Kopp, Sarah J; Ifergan, Igal; Miller, Stephen D; Longnecker, Richard (2020. ) Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection.mBio, , 11 (3 ) , More Information

Sharma, Sripadh; Ifergan, Igal; Kurz, Jonathan E; Linsenmeier, Robert A; Xu, Dan; Cooper, John G; Miller, Stephen D; Kessler, John A (2020. ) Intravenous Immunomodulatory Nanoparticle Treatment for Traumatic Brain Injury.Annals of neurology, , 87 (3 ) ,442-455 More Information

DeBerge, Matthew; Yu, Shuangjin; Dehn, Shirley; Ifergan, Igal; Yeap, Xin Yi; Filipp, Mallory; Becker, Amanda; Luo, Xunrong; Miller, Stephen; Thorp, Edward B (2020. ) Monocytes prime autoreactive T cells after myocardial infarction.American journal of physiology. Heart and circulatory physiology, , 318 (1 ) ,H116-H123 More Information

Podojil, Joseph R; Chiang, Ming-Yi; Ifergan, Igal; Copeland, Ronald; Liu, Linda N; Maloveste, Sebastien; Langermann, Solomon; Liebenson, David; Balabanov, Roumen; Chi, Hongbo; Chen, Lieping; Vignali, Dario A A; Miller, Stephen D (2018. ) B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex.Journal of immunology (Baltimore, Md. : 1950), , 201 (3 ) ,897-907 More Information

Xu, Dan; Robinson, Andrew P; Ishii, Toshiyuki; Duncan, D'Anne S; Alden, Tord D; Goings, Gwendolyn E; Ifergan, Igal; Podojil, Joseph R; Penaloza-MacMaster, Pablo; Kearney, Jennifer A; Swanson, Geoffrey T; Miller, Stephen D; Koh, Sookyong (2018. ) Peripherally derived T regulatory and ?? T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy.The Journal of experimental medicine, , 215 (4 ) ,1169-1186 More Information

Jeong, Su Ji; Cooper, John G; Ifergan, Igal; McGuire, Tammy L; Xu, Dan; Hunter, Zoe; Sharma, Sripadh; McCarthy, Derrick; Miller, Stephen D; Kessler, John A (2017. ) Intravenous immune-modifying nanoparticles as a therapy for spinal cord injury in mice.Neurobiology of disease, , 108 ,73-82 More Information

Plebanek, Michael P; Angeloni, Nicholas L; Vinokour, Elena; Li, Jia; Henkin, Anna; Martinez-Marin, Dalia; Filleur, Stephanie; Bhowmick, Reshma; Henkin, Jack; Miller, Stephen D; Ifergan, Igal; Lee, Yesung; Osman, Iman; Thaxton, C Shad; Volpert, Olga V (2017. ) Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche.Nature communications, , 8 (1 ) ,1319 More Information

Ifergan, Igal; Davidson, Todd S; Kebir, Hania; Xu, Dan; Palacios-Macapagal, Daphne; Cann, Jennifer; Rodgers, Jane M; Hunter, Zoe N; Pittet, Camille L; Beddow, Sara; Jones, Clare A; Prat, Alexandre; Sleeman, Matthew A; Miller, Stephen D (2017. ) Targeting the GM-CSF receptor for the treatment of CNS autoimmunity.Journal of autoimmunity, , 84 ,1-11 More Information

Edwards, Rebecca G; Kopp, Sarah J; Ifergan, Igal; Shui, Jr-Wen; Kronenberg, Mitchell; Miller, Stephen D; Longnecker, Richard (2017. ) Murine Corneal Inflammation and Nerve Damage After Infection With HSV-1 Are Promoted by HVEM and Ameliorated by Immune-Modifying Nanoparticle Therapy.Investigative ophthalmology & visual science, , 58 (1 ) ,282-291 More Information

Smarr, Charles B; Yap, Woon Teck; Neef, Tobias P; Pearson, Ryan M; Hunter, Zoe N; Ifergan, Igal; Getts, Daniel R; Bryce, Paul J; Shea, Lonnie D; Miller, Stephen D (2016. ) Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization.Proceedings of the National Academy of Sciences of the United States of America, , 113 (18 ) ,5059-64 More Information

Ifergan, Igal; Chen, Siqi; Zhang, Bin; Miller, Stephen D (2016. ) Cutting Edge: MicroRNA-223 Regulates Myeloid Dendritic Cell-Driven Th17 Responses in Experimental Autoimmune Encephalomyelitis.Journal of immunology (Baltimore, Md. : 1950), , 196 (4 ) ,1455-1459 More Information

Terry, Rachael L; Ifergan, Igal; Miller, Stephen D (2016. ) Experimental Autoimmune Encephalomyelitis in Mice.Methods in molecular biology (Clifton, N.J.), , 1304 ,145-60 More Information

Larochelle, Catherine; Cayrol, Romain; Kebir, Hania; Alvarez, Jorge Ivan; Lécuyer, Marc-André; Ifergan, Igal; Viel, Émilie; Bourbonnière, Lyne; Beauseigle, Diane; Terouz, Simone; Hachehouche, Lamia; Gendron, Steve; Poirier, Josée; Jobin, Céline; Duquette, Pierre; Flanagan, Ken; Yednock, Ted; Arbour, Nathalie; Prat, Alexandre (2012. ) Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system.Brain : a journal of neurology, , 135 (Pt 10 ) ,2906-24 More Information

Alvarez, Jorge Ivan; Dodelet-Devillers, Aurore; Kebir, Hania; Ifergan, Igal; Fabre, Pierre J; Terouz, Simone; Sabbagh, Mike; Wosik, Karolina; Bourbonnière, Lyne; Bernard, Monique; van Horssen, Jack; de Vries, Helga E; Charron, Frédéric; Prat, Alexandre (2011. ) The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.Science (New York, N.Y.), , 334 (6063 ) ,1727-31 More Information

Ifergan, Igal; Kebir, Hania; Alvarez, Jorge I; Marceau, Gabriel; Bernard, Monique; Bourbonnière, Lyne; Poirier, Josée; Duquette, Pierre; Talbot, Pierre J; Arbour, Nathalie; Prat, Alexandre (2011. ) Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on ?4 integrin.Brain : a journal of neurology, , 134 (Pt 12 ) ,3560-77 More Information

Ifergan, Igal; Kebir, Hania; Terouz, Simone; Alvarez, Jorge I; Lécuyer, Marc-André; Gendron, Steve; Bourbonnière, Lyne; Dunay, Ildiko R; Bouthillier, Alain; Moumdjian, Robert; Fontana, Adriano; Haqqani, Arsalan; Klopstein, Armelle; Prinz, Marco; López-Vales, Rubèn; Birchler, Thomas; Prat, Alexandre (2011. ) Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions.Annals of neurology, , 70 (5 ) ,751-63 More Information

Schneider, Raphael; Mohebiany, Alma Nazlie; Ifergan, Igal; Beauseigle, Diane; Duquette, Pierre; Prat, Alexandre; Arbour, Nathalie (2011. ) B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients.Journal of immunology (Baltimore, Md. : 1950), , 187 (8 ) ,4119-28 More Information

Cayrol, Romain; Haqqani, Arsalan S; Ifergan, Igal; Dodelet-Devillers, Aurore; Prat, Alexandre (2011. ) Isolation of human brain endothelial cells and characterization of lipid raft-associated proteins by mass spectroscopy.Methods in molecular biology (Clifton, N.J.), , 686 ,275-95 More Information

Kebir, Hania; Ifergan, Igal; Alvarez, Jorge Ivan; Bernard, Monique; Poirier, Josée; Arbour, Nathalie; Duquette, Pierre; Prat, Alexandre (2009. ) Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis.Annals of neurology, , 66 (3 ) ,390-402 More Information

Schulze-Topphoff, Ulf; Prat, Alexandre; Prozorovski, Timour; Siffrin, Volker; Paterka, Magdalena; Herz, Josephine; Bendix, Ivo; Ifergan, Igal; Schadock, Ines; Mori, Marcelo A; Van Horssen, Jack; Schröter, Friederike; Smorodchenko, Alina; Han, May Htwe; Bader, Michael; Steinman, Lawrence; Aktas, Orhan; Zipp, Frauke (2009. ) Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.Nature medicine, , 15 (7 ) ,788-93 More Information

Niemelä, Jussi; Ifergan, Igal; Yegutkin, Gennady G; Jalkanen, Sirpa; Prat, Alexander; Airas, Laura (2008. ) IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier.European journal of immunology, , 38 (10 ) ,2718-26 More Information

Ifergan, Igal; Kébir, Hania; Bernard, Monique; Wosik, Karolina; Dodelet-Devillers, Aurore; Cayrol, Romain; Arbour, Nathalie; Prat, Alexandre (2008. ) The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells.Brain : a journal of neurology, , 131 (Pt 3 ) ,785-99 More Information

Cayrol, Romain; Wosik, Karolina; Berard, Jennifer L; Dodelet-Devillers, Aurore; Ifergan, Igal; Kebir, Hania; Haqqani, Arsalan S; Kreymborg, Katharina; Krug, Sebastian; Moumdjian, Robert; Bouthillier, Alain; Becher, Burkhard; Arbour, Nathalie; David, Samuel; Stanimirovic, Danica; Prat, Alexandre (2008. ) Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system.Nature immunology, , 9 (2 ) ,137-45 More Information

Kebir, Hania; Kreymborg, Katharina; Ifergan, Igal; Dodelet-Devillers, Aurore; Cayrol, Romain; Bernard, Monique; Giuliani, Fabrizio; Arbour, Nathalie; Becher, Burkhard; Prat, Alexandre (2007. ) Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation.Nature medicine, , 13 (10 ) ,1173-5 More Information

Ifergan, Igal; Wosik, Karolina; Cayrol, Romain; Kébir, Hania; Auger, Chantale; Bernard, Monique; Bouthillier, Alain; Moumdjian, Robert; Duquette, Pierre; Prat, Alexandre (2006. ) Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis.Annals of neurology, , 60 (1 ) ,45-55 More Information

Magnus, Tim; Schreiner, Bettina; Korn, Thomas; Jack, Carolyn; Guo, Hong; Antel, Jack; Ifergan, Igal; Chen, Lieping; Bischof, Felix; Bar-Or, Amit; Wiendl, Heinz (2005. ) Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 25 (10 ) ,2537-46 More Information

Kim, Ho Jin; Ifergan, Igal; Antel, Jack P; Seguin, Rosanne; Duddy, Martin; Lapierre, Yves; Jalili, Farzaneh; Bar-Or, Amit (2004. ) Type 2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis.Journal of immunology (Baltimore, Md. : 1950), , 172 (11 ) ,7144-53 More Information

Bar-Or, Amit; Nuttall, Robert K; Duddy, Martin; Alter, Andrea; Kim, Ho Jin; Ifergan, Igal; Pennington, Caroline J; Bourgoin, Pierre; Edwards, Dylan R; Yong, V Wee (2003. ) Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis.Brain : a journal of neurology, , 126 (Pt 12 ) ,2738-49 More Information

Ifergan, Igal; Bernard, Nicole F; Bruneau, Julie; Alary, Michel; Tsoukas, Christos M; Roger, Michel (2002. ) Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians.AIDS (London, England), , 16 (17 ) ,2340-2 More Information

Ifergan, Igal; Miller, Stephen D (2020. ) Potential for Targeting Myeloid Cells in Controlling CNS Inflammation.Frontiers in immunology, , 11 ,571897 More Information

Podojil, Joseph R; Ifergan, Igal; Chiang, Ming-Yi; Meeks, Joshua J; Miller, Stephen D (2020. ) Methodology for in vitro Assessment of Human T Cell Activation and Blockade.Bio-protocol, , 10 (11 ) ,e3644 More Information

Xu, Dan; Bhattacharyya, Swati; Wang, Wenxia; Ifergan, Igal; Wong, Ming-Yi Alice Chiang; Procissi, Daniele; Yeldandi, Anjana; Bale, Swarna; Marangoni, Roberta Goncalves; Horbinski, Craig; Miller, Stephen D; Varga, John (2022. ) PLG nanoparticles target fibroblasts and MARCO+ monocytes to reverse multiorgan fibrosis.JCI insight, , 7 (5 ) , More Information

Neef, Tobias; Ifergan, Igal; Beddow, Sara; Penaloza-MacMaster, Pablo; Haskins, Kathryn; Shea, Lonnie D; Podojil, Joseph R; Miller, Stephen D (2021. ) Tolerance Induced by Antigen-Loaded PLG Nanoparticles Affects the Phenotype and Trafficking of Transgenic CD4+ and CD8+ T Cells.Cells, , 10 (12 ) , More Information

Qian, Yuan; Arellano, Gabriel; Ifergan, Igal; Lin, Jean; Snowden, Caroline; Kim, Taehyeung; Thomas, Jane Joy; Law, Calvin; Guan, Tianxia; Balabanov, Roumen D; Kaech, Susan M; Miller, Stephen D; Choi, Jaehyuk (2021. ) ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.Cell reports, , 36 (8 ) ,109602 More Information

Academic - 2258 Medical Sciences Building
Dept. of Molecular Genetics, Biochemistry & Microbiology
Cincinnati  Ohio, 45267
Phone: 513-558-7146
igal.ifergan@uc.edu