Igal Ifergan, PhD

B.S.: Université de Montréal Montréal, (Microbiology and Immunology)

M.S.: Université de Montréal Montréal, (Microbiology and Immunology)

Ph.D.: Université de Montréal Montréal, (Neuro-Immunology)

Role of the neurovascular molecule Wnt in regulating CNS inflammatory responses

- Post-Doc, Northwestern University, Chicago

- Research Assistant Professor, Northwestern University, Chicago

Grant: #PP-2008-37129 Investigators:Ifergan, Igal 08-01-2020 -07-31-2021 National Multiple Sclerosis Society Induction of Immunoregulatory Microglia by the Wnt Pathway During Neuroinflammation Role:PI 37295.00 Hold Level:Non Profit

Grant: #R35GM146890 Investigators:Ifergan, Igal 08-01-2022 -06-30-2027 National Institute of General Medical Sciences Role of the neurovascular molecule Wnt in regulating CNS inflammatory responses Role:PI 356907.00 Awarded Level:Federal

Grant: #R03NS144870 -06-30-2027 National Institute of Neurological Disorders and Stroke Role of NK cell subsets in an animal model of relapsing-remitting multiple sclerosis Role:PI 0.00 Hold Level:Federal

Grant: #R03NS144870 -06-30-2027 National Institute of Neurological Disorders and Stroke Role of NK cell subsets in an animal model of relapsing-remitting multiple sclerosis Role:PI 0.00 Hold Level:Federal

Peer Reviewed Publications

Cortez, Jessica T; Montauti, Elena; Shifrut, Eric; Gatchalian, Jovylyn; Zhang, Yusi; Shaked, Oren; Xu, Yuanming; Roth, Theodore L; Simeonov, Dimitre R; Zhang, Yana; Chen, Siqi; Li, Zhongmei; Woo, Jonathan M; Ho, Josephine; Vogel, Ian A; Prator, Grace Y; Zhang, Bin; Lee, Youjin; Sun, Zhaolin; Ifergan, Igal; Van Gool, Frédéric; Hargreaves, Diana C; Bluestone, Jeffrey A; Marson, Alexander; Fang, Deyu  (2020). CRISPR screen in regulatory T cells reveals modulators of Foxp3. Nature, 582 (7812) , 416-420More Information

Park, Seo J; Riccio, Rachel E; Kopp, Sarah J; Ifergan, Igal; Miller, Stephen D; Longnecker, Richard  (2020). Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection. mBio, 11 (3) More Information

Sharma, Sripadh; Ifergan, Igal; Kurz, Jonathan E; Linsenmeier, Robert A; Xu, Dan; Cooper, John G; Miller, Stephen D; Kessler, John A  (2020). Intravenous Immunomodulatory Nanoparticle Treatment for Traumatic Brain Injury. Annals of neurology, 87 (3) , 442-455More Information

DeBerge, Matthew; Yu, Shuangjin; Dehn, Shirley; Ifergan, Igal; Yeap, Xin Yi; Filipp, Mallory; Becker, Amanda; Luo, Xunrong; Miller, Stephen; Thorp, Edward B  (2020). Monocytes prime autoreactive T cells after myocardial infarction. American journal of physiology. Heart and circulatory physiology, 318 (1) , H116-H123More Information

Podojil, Joseph R; Chiang, Ming-Yi; Ifergan, Igal; Copeland, Ronald; Liu, Linda N; Maloveste, Sebastien; Langermann, Solomon; Liebenson, David; Balabanov, Roumen; Chi, Hongbo; Chen, Lieping; Vignali, Dario A A; Miller, Stephen D  (2018). B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex. Journal of immunology (Baltimore, Md. : 1950), 201 (3) , 897-907More Information

Xu, Dan; Robinson, Andrew P; Ishii, Toshiyuki; Duncan, D'Anne S; Alden, Tord D; Goings, Gwendolyn E; Ifergan, Igal; Podojil, Joseph R; Penaloza-MacMaster, Pablo; Kearney, Jennifer A; Swanson, Geoffrey T; Miller, Stephen D; Koh, Sookyong  (2018). Peripherally derived T regulatory and ?? T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy. The Journal of experimental medicine, 215 (4) , 1169-1186More Information

Jeong, Su Ji; Cooper, John G; Ifergan, Igal; McGuire, Tammy L; Xu, Dan; Hunter, Zoe; Sharma, Sripadh; McCarthy, Derrick; Miller, Stephen D; Kessler, John A  (2017). Intravenous immune-modifying nanoparticles as a therapy for spinal cord injury in mice. Neurobiology of disease, 108, 73-82More Information

Plebanek, Michael P; Angeloni, Nicholas L; Vinokour, Elena; Li, Jia; Henkin, Anna; Martinez-Marin, Dalia; Filleur, Stephanie; Bhowmick, Reshma; Henkin, Jack; Miller, Stephen D; Ifergan, Igal; Lee, Yesung; Osman, Iman; Thaxton, C Shad; Volpert, Olga V  (2017). Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche. Nature communications, 8 (1) , 1319More Information

Ifergan, Igal; Davidson, Todd S; Kebir, Hania; Xu, Dan; Palacios-Macapagal, Daphne; Cann, Jennifer; Rodgers, Jane M; Hunter, Zoe N; Pittet, Camille L; Beddow, Sara; Jones, Clare A; Prat, Alexandre; Sleeman, Matthew A; Miller, Stephen D  (2017). Targeting the GM-CSF receptor for the treatment of CNS autoimmunity. Journal of autoimmunity, 84, 1-11More Information

Edwards, Rebecca G; Kopp, Sarah J; Ifergan, Igal; Shui, Jr-Wen; Kronenberg, Mitchell; Miller, Stephen D; Longnecker, Richard  (2017). Murine Corneal Inflammation and Nerve Damage After Infection With HSV-1 Are Promoted by HVEM and Ameliorated by Immune-Modifying Nanoparticle Therapy. Investigative ophthalmology & visual science, 58 (1) , 282-291More Information

Smarr, Charles B; Yap, Woon Teck; Neef, Tobias P; Pearson, Ryan M; Hunter, Zoe N; Ifergan, Igal; Getts, Daniel R; Bryce, Paul J; Shea, Lonnie D; Miller, Stephen D  (2016). Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization. Proceedings of the National Academy of Sciences of the United States of America, 113 (18) , 5059-64More Information

Ifergan, Igal; Chen, Siqi; Zhang, Bin; Miller, Stephen D  (2016). Cutting Edge: MicroRNA-223 Regulates Myeloid Dendritic Cell-Driven Th17 Responses in Experimental Autoimmune Encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950), 196 (4) , 1455-1459More Information

Terry, Rachael L; Ifergan, Igal; Miller, Stephen D  (2016). Experimental Autoimmune Encephalomyelitis in Mice. Methods in molecular biology (Clifton, N.J.), 1304, 145-60More Information

Larochelle, Catherine; Cayrol, Romain; Kebir, Hania; Alvarez, Jorge Ivan; Lécuyer, Marc-André; Ifergan, Igal; Viel, Émilie; Bourbonnière, Lyne; Beauseigle, Diane; Terouz, Simone; Hachehouche, Lamia; Gendron, Steve; Poirier, Josée; Jobin, Céline; Duquette, Pierre; Flanagan, Ken; Yednock, Ted; Arbour, Nathalie; Prat, Alexandre  (2012). Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system. Brain : a journal of neurology, 135 (Pt 10) , 2906-24More Information

Alvarez, Jorge Ivan; Dodelet-Devillers, Aurore; Kebir, Hania; Ifergan, Igal; Fabre, Pierre J; Terouz, Simone; Sabbagh, Mike; Wosik, Karolina; Bourbonnière, Lyne; Bernard, Monique; van Horssen, Jack; de Vries, Helga E; Charron, Frédéric; Prat, Alexandre  (2011). The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science (New York, N.Y.), 334 (6063) , 1727-31More Information

Ifergan, Igal; Kebir, Hania; Alvarez, Jorge I; Marceau, Gabriel; Bernard, Monique; Bourbonnière, Lyne; Poirier, Josée; Duquette, Pierre; Talbot, Pierre J; Arbour, Nathalie; Prat, Alexandre  (2011). Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on ?4 integrin. Brain : a journal of neurology, 134 (Pt 12) , 3560-77More Information

Ifergan, Igal; Kebir, Hania; Terouz, Simone; Alvarez, Jorge I; Lécuyer, Marc-André; Gendron, Steve; Bourbonnière, Lyne; Dunay, Ildiko R; Bouthillier, Alain; Moumdjian, Robert; Fontana, Adriano; Haqqani, Arsalan; Klopstein, Armelle; Prinz, Marco; López-Vales, Rubèn; Birchler, Thomas; Prat, Alexandre  (2011). Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions. Annals of neurology, 70 (5) , 751-63More Information

Schneider, Raphael; Mohebiany, Alma Nazlie; Ifergan, Igal; Beauseigle, Diane; Duquette, Pierre; Prat, Alexandre; Arbour, Nathalie  (2011). B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients. Journal of immunology (Baltimore, Md. : 1950), 187 (8) , 4119-28More Information

Cayrol, Romain; Haqqani, Arsalan S; Ifergan, Igal; Dodelet-Devillers, Aurore; Prat, Alexandre  (2011). Isolation of human brain endothelial cells and characterization of lipid raft-associated proteins by mass spectroscopy. Methods in molecular biology (Clifton, N.J.), 686, 275-95More Information

Kebir, Hania; Ifergan, Igal; Alvarez, Jorge Ivan; Bernard, Monique; Poirier, Josée; Arbour, Nathalie; Duquette, Pierre; Prat, Alexandre  (2009). Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis. Annals of neurology, 66 (3) , 390-402More Information

Schulze-Topphoff, Ulf; Prat, Alexandre; Prozorovski, Timour; Siffrin, Volker; Paterka, Magdalena; Herz, Josephine; Bendix, Ivo; Ifergan, Igal; Schadock, Ines; Mori, Marcelo A; Van Horssen, Jack; Schröter, Friederike; Smorodchenko, Alina; Han, May Htwe; Bader, Michael; Steinman, Lawrence; Aktas, Orhan; Zipp, Frauke  (2009). Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system. Nature medicine, 15 (7) , 788-93More Information

Niemelä, Jussi; Ifergan, Igal; Yegutkin, Gennady G; Jalkanen, Sirpa; Prat, Alexander; Airas, Laura  (2008). IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. European journal of immunology, 38 (10) , 2718-26More Information

Ifergan, Igal; Kébir, Hania; Bernard, Monique; Wosik, Karolina; Dodelet-Devillers, Aurore; Cayrol, Romain; Arbour, Nathalie; Prat, Alexandre  (2008). The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells. Brain : a journal of neurology, 131 (Pt 3) , 785-99More Information

Cayrol, Romain; Wosik, Karolina; Berard, Jennifer L; Dodelet-Devillers, Aurore; Ifergan, Igal; Kebir, Hania; Haqqani, Arsalan S; Kreymborg, Katharina; Krug, Sebastian; Moumdjian, Robert; Bouthillier, Alain; Becher, Burkhard; Arbour, Nathalie; David, Samuel; Stanimirovic, Danica; Prat, Alexandre  (2008). Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system. Nature immunology, 9 (2) , 137-45More Information

Kebir, Hania; Kreymborg, Katharina; Ifergan, Igal; Dodelet-Devillers, Aurore; Cayrol, Romain; Bernard, Monique; Giuliani, Fabrizio; Arbour, Nathalie; Becher, Burkhard; Prat, Alexandre  (2007). Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nature medicine, 13 (10) , 1173-5More Information

Ifergan, Igal; Wosik, Karolina; Cayrol, Romain; Kébir, Hania; Auger, Chantale; Bernard, Monique; Bouthillier, Alain; Moumdjian, Robert; Duquette, Pierre; Prat, Alexandre  (2006). Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis. Annals of neurology, 60 (1) , 45-55More Information

Magnus, Tim; Schreiner, Bettina; Korn, Thomas; Jack, Carolyn; Guo, Hong; Antel, Jack; Ifergan, Igal; Chen, Lieping; Bischof, Felix; Bar-Or, Amit; Wiendl, Heinz  (2005). Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25 (10) , 2537-46More Information

Kim, Ho Jin; Ifergan, Igal; Antel, Jack P; Seguin, Rosanne; Duddy, Martin; Lapierre, Yves; Jalili, Farzaneh; Bar-Or, Amit  (2004). Type 2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis. Journal of immunology (Baltimore, Md. : 1950), 172 (11) , 7144-53More Information

Bar-Or, Amit; Nuttall, Robert K; Duddy, Martin; Alter, Andrea; Kim, Ho Jin; Ifergan, Igal; Pennington, Caroline J; Bourgoin, Pierre; Edwards, Dylan R; Yong, V Wee  (2003). Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. Brain : a journal of neurology, 126 (Pt 12) , 2738-49More Information

Ifergan, Igal; Bernard, Nicole F; Bruneau, Julie; Alary, Michel; Tsoukas, Christos M; Roger, Michel  (2002). Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians. AIDS (London, England), 16 (17) , 2340-2More Information

Ifergan, Igal; Miller, Stephen D  (2020). Potential for Targeting Myeloid Cells in Controlling CNS Inflammation. Frontiers in immunology, 11, 571897More Information

Podojil, Joseph R; Ifergan, Igal; Chiang, Ming-Yi; Meeks, Joshua J; Miller, Stephen D  (2020). Methodology for in vitro Assessment of Human T Cell Activation and Blockade. Bio-protocol, 10 (11) , e3644More Information

Xu, Dan; Bhattacharyya, Swati; Wang, Wenxia; Ifergan, Igal; Wong, Ming-Yi Alice Chiang; Procissi, Daniele; Yeldandi, Anjana; Bale, Swarna; Marangoni, Roberta Goncalves; Horbinski, Craig; Miller, Stephen D; Varga, John  (2022). PLG nanoparticles target fibroblasts and MARCO+ monocytes to reverse multiorgan fibrosis. JCI insight, 7 (5) More Information

Neef, Tobias; Ifergan, Igal; Beddow, Sara; Penaloza-MacMaster, Pablo; Haskins, Kathryn; Shea, Lonnie D; Podojil, Joseph R; Miller, Stephen D  (2021). Tolerance Induced by Antigen-Loaded PLG Nanoparticles Affects the Phenotype and Trafficking of Transgenic CD4+ and CD8+ T Cells. Cells, 10 (12) More Information

Qian, Yuan; Arellano, Gabriel; Ifergan, Igal; Lin, Jean; Snowden, Caroline; Kim, Taehyeung; Thomas, Jane Joy; Law, Calvin; Guan, Tianxia; Balabanov, Roumen D; Kaech, Susan M; Miller, Stephen D; Choi, Jaehyuk  (2021). ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis. Cell reports, 36 (8) , 109602More Information

Academic - 2258 Medical Sciences Building
Dept. of Molecular Genetics, Biochemistry & Microbiology
Cincinnati  Ohio, 45267
Phone: 513-558-7146
igal.ifergan@uc.edu