Traian Ionascu

Traian Dan Ionascu , PhD

Associate Professor of Clinical

UC Barrett Cancer Center
234 Goodman Street, ML 0757
Cincinnati, Ohio 45219
Phone 513-558-4342
Fax 513-584-4007
Email dan.ionascu@uc.edu

Education

Bachelor's Degree: University of Bucharest Bucharest, RO, 1994 (Physics)

Master's Degree: University of Bucharest Bucharest, RO, 1995 (Physics)

Master's Degree: Northeastern University Boston, MA, 1999 (Physics)

Doctoral Degree: Northeastern University Boston, MA, 2005 (Physics)

Posdoctoral Fellowship: Harvard Medical School Boston, MA, 2018 (Medical Physics-Radiation Oncology)

Research and Practice Interests

Radiation Physics
Treatment Planning
Tumor Tracking
Advanced Imaging Techniques
Pre-clinical Radiation Research and Radiobiology
Vibrational Coherence Spectroscopy
Biomolecule Dynamics
Optics and Microscopy

Positions and Work Experience

09-2005 -09-2008 Postoctoral Fellow, Medical Physics, Harvard Medical School--Brigham and Women's Hospital, Boston, MA

10-2008 -12-2016 Medical Physicist, Beaumont Health, Royal Oak, MI

01-2011 -12-2016 Assistant Professor, Radiation Oncology, Oakland University William Beaumont School of Medicine, Auburn Hills, MI

01-2017 -To Present Associate Professor, Radiation Oncology, University of Cincinnati College of Medicine, Cincinnati, OH

Research Support

Investigators:D. Ionascu, M. Lamba 06-01-2018 -05-31-2020 Varian, Inc. Varian Role:Co-PI $77,000 Active Type:Grant

Investigators:R. Berbeco, D. Ionascu 2008 JCRT Foundation Delivered dose reconstruction with beam’s-eye-view images Role:Co-Investigator $45,000 Completed Type:Grant

Investigators:R Berbeco, D. Ionascu 2007 -2008 Varian Medical Systems, Inc. Beam's-eye-view imaging for online/offline treatment localization and dosimetric verification Role:Co-Investigator $138,750 Completed Type:Grant

Investigators:R. Berbeco, D.Ionascu 2006 Varian Medical Systems, Inc. Using an EPID in cine mode for on-line treatment verification Role:Co-Investigator $51,750 Completed Type:Grant

Grant: #Contract No. 475524 Investigators:Ionascu, Traian; Lamba, Michael; Takiar, Vinita; Vatner, Ralph 08-02-2019 -07-31-2020 Department of Energy Evaluating Equivalence of Cellular Response to X-ray and Gamma Irradiation of Varying Energies Role:Collaborator $53,489.25 Active Level:Federal

Publications

Peer Reviewed Publications

Guo, Minghao; Chee, Geraldine; O'Connell, Dylan; Dhou, Salam; Fu, Jie; Singhrao, Kamal; Ionascu, Dan; Ruan, Dan; Lee, Percy; Low, Daniel A; Zhao, Jun; Lewis, John H (2019. ) Reconstruction of a high-quality volumetric image and a respiratory motion model from patient CBCT projections.Medical physics, , 46 (8 ) ,3627-3639 More Information

Qin, An; Ionascu, Dan; Liang, Jian; Han, Xiao; O'Connell, Nicolette; Yan, Di (2018. ) The evaluation of a hybrid biomechanical deformable registration method on a multistage physical phantom with reproducible deformation.Radiation oncology (London, England), , 13 (1 ) ,240 More Information

Dhou, S; Hurwitz, M; Mishra, P; Cai, W; Rottmann, J; Li, R; Williams, C; Wagar, M; Berbeco, R; Ionascu, D; Lewis, J H (2015. ) 3D fluoroscopic image estimation using patient-specific 4DCBCT-based motion models.Physics in medicine and biology, , 60 (9 ) ,3807-24 More Information

Mangona, Victor S; Aneese, Andrew M; Marina, Ovidiu; Hymas, Richard V; Ionascu, Dan; Robertson, John M; Gallardo, Lori J; Grills, Inga Siiner (2015. ) Toxicity after central versus peripheral lung stereotactic body radiation therapy: a propensity score matched-pair analysis.International journal of radiation oncology, biology, physics, , 91 (1 ) ,124-32 More Information

Zhuang, Ling; Yan, Di; Liang, Jian; Ionascu, Dan; Mangona, Victor; Yang, Kai; Zhou, Jun (2014. ) Evaluation of image guided motion management methods in lung cancer radiotherapy.Medical physics, , 41 (3 ) ,031911 More Information

Zhuang, Ling; Liang, Jian; Yan, Di; Zhang, Tiezhi; Marina, Ovidiu; Ionascu, Dan (2013. ) An optimization algorithm for 3D real-time lung tumor tracking during arc therapy using kV projection images.Medical physics, , 40 (10 ) ,101710 More Information

Kim, Joshua; Ionascu, Dan; Zhang, Tiezhi (2013. ) Technical note: algebraic iterative image reconstruction using a cylindrical image grid for tetrahedron beam computed tomography.Medical physics, , 40 (8 ) ,081909 More Information

Mohammed, Nasiruddin; Kestin, Larry; Grills, Inga; Shah, Chirag; Glide-Hurst, Carri; Yan, Di; Ionascu, Dan (2012. ) Comparison of IGRT registration strategies for optimal coverage of primary lung tumors and involved nodes based on multiple four-dimensional CT scans obtained throughout the radiotherapy course.International journal of radiation oncology, biology, physics, , 82 (4 ) ,1541-8 More Information

Glide-Hurst, Carri K; Ionascu, Dan; Berbeco, Ross; Yan, Di (2011. ) Coupling surface cameras with on-board fluoroscopy: a feasibility study.Medical physics, , 38 (6 ) ,2937-47 More Information

Court, Laurence E; Seco, Joao; Lu, Xing-Qi; Ebe, Kazuyu; Mayo, Charles; Ionascu, Dan; Winey, Brian; Giakoumakis, Nikos; Aristophanous, Michalis; Berbeco, Ross; Rottman, Joerg; Bogdanov, Madeleine; Schofield, Deborah; Lingos, Tania (2010. ) Use of a realistic breathing lung phantom to evaluate dose delivery errors.Medical physics, , 37 (11 ) ,5850-7 More Information

Court, Laurence; Wagar, Matthew; Bogdanov, Madeleine; Ionascu, Dan; Schofield, Deborah; Allen, Aaron; Berbeco, Ross; Lingos, Tania (2010. ) Use of reduced dose rate when treating moving tumors using dynamic IMRT.Journal of applied clinical medical physics, , 12 (1 ) ,3276 More Information

Court, Laurence; Wagar, Matthew; Berbeco, Ross; Reisner, Adam; Winey, Brian; Schofield, Debbie; Ionascu, Dan; Allen, Aaron M; Popple, Richard; Lingos, Tania (2010. ) Evaluation of the interplay effect when using RapidArc to treat targets moving in the craniocaudal or right-left direction.Medical physics, , 37 (1 ) ,4-11 More Information

Park, Sang-June; Ionascu, Dan; Hacker, Fred; Mamon, Harvey; Berbeco, Ross (2009. ) Automatic marker detection and 3D position reconstruction using cine EPID images for SBRT verification.Medical physics, , 36 (10 ) ,4536-46 More Information

Park, Sang-June; Ionascu, Dan; Killoran, Joseph; Mamede, Marcelo; Gerbaudo, Victor H; Chin, Lee; Berbeco, Ross (2008. ) Evaluation of the combined effects of target size, respiratory motion and background activity on 3D and 4D PET/CT images.Physics in medicine and biology, , 53 (13 ) ,3661-79 More Information

Berbeco, Ross I; Hacker, Fred; Zatwarnicki, Chris; Park, Sang-June; Ionascu, Dan; O'Farrell, Desmond; Mamon, Harvey J (2008. ) A novel method for estimating SBRT delivered dose with beam's-eye-view images.Medical physics, , 35 (7 ) ,3225-31 More Information

Gruia, Flaviu; Ionascu, Dan; Kubo, Minoru; Ye, Xiong; Dawson, John; Osborne, Robert L; Sligar, S G; Denisov, Ilia; Das, Aditi; Poulos, T L; Terner, James; Champion, Paul M (2008. ) Low-frequency dynamics of Caldariomyces fumago chloroperoxidase probed by femtosecond coherence spectroscopy.Biochemistry, , 47 (18 ) ,5156-67 More Information

Court, Laurence E; Wagar, Matthew; Ionascu, Dan; Berbeco, Ross; Chin, Lee (2008. ) Management of the interplay effect when using dynamic MLC sequences to treat moving targets.Medical physics, , 35 (5 ) ,1926-31 More Information

Gruia, Flaviu; Ye, Xiong; Ionascu, Dan; Kubo, Minoru; Champion, Paul M (2007. ) Low frequency spectral density of ferrous heme: perturbations induced by axial ligation and protein insertion.Biophysical journal, , 93 (12 ) ,4404-13 More Information

Ionascu, Dan; Jiang, Steve B; Nishioka, Seiko; Shirato, Hiroki; Berbeco, Ross I (2007. ) Internal-external correlation investigations of respiratory induced motion of lung tumors.Medical physics, , 34 (10 ) ,3893-903 More Information

Ye, Xiong; Ionascu, Dan; Gruia, Florin; Yu, Anchi; Benabbas, Abdelkrim; Champion, Paul M (2007. ) Temperature-dependent heme kinetics with nonexponential binding and barrier relaxation in the absence of protein conformational substates.Proceedings of the National Academy of Sciences of the United States of America, , 104 (37 ) ,14682-7 More Information

Berbeco, Ross I; Hacker, Fred; Ionascu, Dan; Mamon, Harvey J (2007. ) Clinical feasibility of using an EPID in CINE mode for image-guided verification of stereotactic body radiotherapy.International journal of radiation oncology, biology, physics, , 69 (1 ) ,258-66 More Information

Ionascu, Dan; Gruia, Flaviu; Ye, Xiong; Yu, Anchi; Rosca, Florin; Beck, Chris; Demidov, Andrey; Olson, John S; Champion, Paul M (2005. ) Temperature-dependent studies of NO recombination to heme and heme proteins.Journal of the American Chemical Society, , 127 (48 ) ,16921-34 More Information

Ye, Xiong; Yu, Anchi; Georgiev, Georgi Y; Gruia, Florin; Ionascu, Dan; Cao, Wenxiang; Sage, J Timothy; Champion, Paul M (2005. ) CO rebinding to protoheme: investigations of the proximal and distal contributions to the geminate rebinding barrier.Journal of the American Chemical Society, , 127 (16 ) ,5854-61 More Information

Champion, Paul M; Rosca, Florin; Ionascu, Dan; Cao, Wenxiang; Ye, Xiong (2004. ) Rapid timescale processes and the role of electronic surface coupling in the photolysis of diatomic ligands from heme proteins. Faraday discussions, , 127 ,123-35

Killoran, Joseph H; Gerbaudo, Victor H; Mamede, Marcelo; Ionascu, Dan; Park, Sang-June; Berbeco, Ross (2011. ) Motion artifacts occurring at the lung/diaphragm interface using 4D CT attenuation correction of 4D PET scans.Journal of applied clinical medical physics, , 12 (4 ) ,3502 More Information

Gruia, Flaviu; Kubo, Minoru; Ye, Xiong; Ionascu, Dan; Lu, Changyuan; Poole, Robert K; Yeh, Syun-Ru; Champion, Paul M (2008. ) Coherence spectroscopy investigations of the low-frequency vibrations of heme: effects of protein-specific perturbations.Journal of the American Chemical Society, , 130 (15 ) ,5231-44 More Information

Sertorio, Mathieu; Nowrouzi, Ali; Akbarpour, Mahdi; Chetal, Kashish; Salomonis, Nathan; Brons, Stephan; Mascia, Anthony; Ionascu, Dan; Shelby McCauley, ; Kupneski, Taylor; Köthe, Andreas; Debus, Jürgen; Perentesis, John P; Abdollahi, Amir; Zheng, Yi; Wells, Susanne I (2020. ) Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, , More Information

Pomeranz Krummel, Daniel A; Nasti, Tahseen H; Kaluzova, Milota; Kallay, Laura; Bhattacharya, Debanjan; Melms, Johannes C; Izar, Benjamin; Xu, Maxwell; Burnham, Andre; Ahmed, Taukir; Li, Guanguan; Lawson, David; Kowalski, Jeanne; Cao, Yichun; Switchenko, Jeffrey M; Ionascu, Dan; Cook, James M; Medvedovic, Mario; Jenkins, Andrew; Khan, Mohammad K; Sengupta, Soma (2020. ) Melanoma Cell Intrinsic GABAA Receptor Enhancement Potentiates Radiation and Immune Checkpoint Inhibitor Response by Promoting Direct and T Cell-Mediated Antitumor Activity.International journal of radiation oncology, biology, physics, , More Information

Dhou, Salam; Lewis, John; Cai, Weixing; Ionascu, Dan; Williams, Christopher (2020. ) Quantifying day-to-day variations in 4DCBCT-based PCA motion models.Biomedical physics & engineering express, , 6 (3 ) ,035020 More Information

Service

American Association of Physicists in Medicine (Workgroup on Treatment Planning (WGTP) ) Committee Member Type:Service to Professional Associations Level:National 04-18-2018 -12-31-2020

American Association of Physicists in Medicine (Working Group on a Professional Doctorate Degree for Medical Physics (WGPDMP) ) Committee Member Type:Service to Professional Associations Level:National 05-28-2019 -12-31-2021

Professional Affiliation

2004 -To Present: Member American Association of Physicists in Medicine (AAPM),

Patents and Inventions

US8539948 Hyperthermia Assisted Radiation Therapy Dan Ionascu, Brian Marples, Di Yan, Alvaro Martinez , Awarded 09-24-2013 Inventor

Contact Information

Academic - UC Barrett Cancer Center
234 Goodman Street, ML 0757
Cincinnati  Ohio, 45219
Phone: 513-558-4342
Fax: 513-584-4007
dan.ionascu@uc.edu