Traian Dan Ionascu, PHD

B.S/M.S.: University of Bucharest Bucharest, RO, 1994 (Engineering Physics)

M.S.: University of Bucharest Bucharest, RO, 1995 (Semiconductors Physics)

M.S.: Northeastern University Boston, MA, 1999 (Physics)

Ph.D.: Northeastern University Boston, MA, 2005 (Physics)

Postdoc: Harvard/BWH Boston, MA, 2008 (Medical Physics)

Radiation Physics
Treatment Planning
Tumor Tracking
Advanced Imaging Techniques
Pre-clinical Radiation Research and Radiobiology
Vibrational Coherence Spectroscopy
Biomolecule Dynamics
Optics and Microscopy
 

09-2005 -09-2008 Postoctoral Fellow, Medical Physics, Harvard Medical School--Brigham and Women's Hospital, Boston, MA

10-2008 -12-2016 Medical Physicist, Beaumont Health, Royal Oak, MI

01-2011 -12-2016 Assistant Professor, Radiation Oncology, Oakland University William Beaumont School of Medicine, Auburn Hills, MI

01-2017 -09-2024 Associate Professor, Radiation Oncology, University of Cincinnati College of Medicine, Cincinnati, OH

09-2024 -To Present Professor, Radiation Oncology University of Cincinnatii College of Medicine, Cincinnati, OH

12-2021 -To Present Director of Medical Physics Residency, Radiation Oncology, University of Cincinnati College of Medicine, Cincinnati, OH

Investigators:D. Ionascu, M. Lamba 06-01-2018 -05-31-2020 Varian, Inc. Varian Role:Co-PI $77,000 Completed Type:Grant

Grant: #Contract No. 475524 Investigators:Ionascu, Traian; Lamba, Michael; Takiar, Vinita; Vatner, Ralph 08-02-2019 -07-31-2020 Department of Energy Evaluating Equivalence of Cellular Response to X-ray and Gamma Irradiation of Varying Energies Role:Collaborator $53,489.25 Completed Type:Grant

Peer Reviewed Publications

Guo, Minghao; Chee, Geraldine; O'Connell, Dylan; Dhou, Salam; Fu, Jie; Singhrao, Kamal; Ionascu, Dan; Ruan, Dan; Lee, Percy; Low, Daniel A; Zhao, Jun; Lewis, John H  (2019). Reconstruction of a high-quality volumetric image and a respiratory motion model from patient CBCT projections. Medical physics, 46 (8) , 3627-3639More Information

Qin, An; Ionascu, Dan; Liang, Jian; Han, Xiao; O'Connell, Nicolette; Yan, Di  (2018). The evaluation of a hybrid biomechanical deformable registration method on a multistage physical phantom with reproducible deformation. Radiation oncology (London, England), 13 (1) , 240More Information

Dhou, S; Hurwitz, M; Mishra, P; Cai, W; Rottmann, J; Li, R; Williams, C; Wagar, M; Berbeco, R; Ionascu, D; Lewis, J H  (2015). 3D fluoroscopic image estimation using patient-specific 4DCBCT-based motion models. Physics in medicine and biology, 60 (9) , 3807-24More Information

Mangona, Victor S; Aneese, Andrew M; Marina, Ovidiu; Hymas, Richard V; Ionascu, Dan; Robertson, John M; Gallardo, Lori J; Grills, Inga Siiner  (2015). Toxicity after central versus peripheral lung stereotactic body radiation therapy: a propensity score matched-pair analysis. International journal of radiation oncology, biology, physics, 91 (1) , 124-32More Information

Zhuang, Ling; Yan, Di; Liang, Jian; Ionascu, Dan; Mangona, Victor; Yang, Kai; Zhou, Jun  (2014). Evaluation of image guided motion management methods in lung cancer radiotherapy. Medical physics, 41 (3) , 031911More Information

Zhuang, Ling; Liang, Jian; Yan, Di; Zhang, Tiezhi; Marina, Ovidiu; Ionascu, Dan  (2013). An optimization algorithm for 3D real-time lung tumor tracking during arc therapy using kV projection images. Medical physics, 40 (10) , 101710More Information

Kim, Joshua; Ionascu, Dan; Zhang, Tiezhi  (2013). Technical note: algebraic iterative image reconstruction using a cylindrical image grid for tetrahedron beam computed tomography. Medical physics, 40 (8) , 081909More Information

Mohammed, Nasiruddin; Kestin, Larry; Grills, Inga; Shah, Chirag; Glide-Hurst, Carri; Yan, Di; Ionascu, Dan  (2012). Comparison of IGRT registration strategies for optimal coverage of primary lung tumors and involved nodes based on multiple four-dimensional CT scans obtained throughout the radiotherapy course. International journal of radiation oncology, biology, physics, 82 (4) , 1541-8More Information

Glide-Hurst, Carri K; Ionascu, Dan; Berbeco, Ross; Yan, Di  (2011). Coupling surface cameras with on-board fluoroscopy: a feasibility study. Medical physics, 38 (6) , 2937-47More Information

Court, Laurence E; Seco, Joao; Lu, Xing-Qi; Ebe, Kazuyu; Mayo, Charles; Ionascu, Dan; Winey, Brian; Giakoumakis, Nikos; Aristophanous, Michalis; Berbeco, Ross; Rottman, Joerg; Bogdanov, Madeleine; Schofield, Deborah; Lingos, Tania  (2010). Use of a realistic breathing lung phantom to evaluate dose delivery errors. Medical physics, 37 (11) , 5850-7More Information

Court, Laurence; Wagar, Matthew; Bogdanov, Madeleine; Ionascu, Dan; Schofield, Deborah; Allen, Aaron; Berbeco, Ross; Lingos, Tania  (2010). Use of reduced dose rate when treating moving tumors using dynamic IMRT. Journal of applied clinical medical physics, 12 (1) , 3276More Information

Court, Laurence; Wagar, Matthew; Berbeco, Ross; Reisner, Adam; Winey, Brian; Schofield, Debbie; Ionascu, Dan; Allen, Aaron M; Popple, Richard; Lingos, Tania  (2010). Evaluation of the interplay effect when using RapidArc to treat targets moving in the craniocaudal or right-left direction. Medical physics, 37 (1) , 4-11More Information

Park, Sang-June; Ionascu, Dan; Hacker, Fred; Mamon, Harvey; Berbeco, Ross  (2009). Automatic marker detection and 3D position reconstruction using cine EPID images for SBRT verification. Medical physics, 36 (10) , 4536-46More Information

Park, Sang-June; Ionascu, Dan; Killoran, Joseph; Mamede, Marcelo; Gerbaudo, Victor H; Chin, Lee; Berbeco, Ross  (2008). Evaluation of the combined effects of target size, respiratory motion and background activity on 3D and 4D PET/CT images. Physics in medicine and biology, 53 (13) , 3661-79More Information

Berbeco, Ross I; Hacker, Fred; Zatwarnicki, Chris; Park, Sang-June; Ionascu, Dan; O'Farrell, Desmond; Mamon, Harvey J  (2008). A novel method for estimating SBRT delivered dose with beam's-eye-view images. Medical physics, 35 (7) , 3225-31More Information

Gruia, Flaviu; Ionascu, Dan; Kubo, Minoru; Ye, Xiong; Dawson, John; Osborne, Robert L; Sligar, S G; Denisov, Ilia; Das, Aditi; Poulos, T L; Terner, James; Champion, Paul M  (2008). Low-frequency dynamics of Caldariomyces fumago chloroperoxidase probed by femtosecond coherence spectroscopy. Biochemistry, 47 (18) , 5156-67More Information

Court, Laurence E; Wagar, Matthew; Ionascu, Dan; Berbeco, Ross; Chin, Lee  (2008). Management of the interplay effect when using dynamic MLC sequences to treat moving targets. Medical physics, 35 (5) , 1926-31More Information

Gruia, Flaviu; Ye, Xiong; Ionascu, Dan; Kubo, Minoru; Champion, Paul M  (2007). Low frequency spectral density of ferrous heme: perturbations induced by axial ligation and protein insertion. Biophysical journal, 93 (12) , 4404-13More Information

Ionascu, Dan; Jiang, Steve B; Nishioka, Seiko; Shirato, Hiroki; Berbeco, Ross I  (2007). Internal-external correlation investigations of respiratory induced motion of lung tumors. Medical physics, 34 (10) , 3893-903More Information

Ye, Xiong; Ionascu, Dan; Gruia, Florin; Yu, Anchi; Benabbas, Abdelkrim; Champion, Paul M  (2007). Temperature-dependent heme kinetics with nonexponential binding and barrier relaxation in the absence of protein conformational substates. Proceedings of the National Academy of Sciences of the United States of America, 104 (37) , 14682-7More Information

Berbeco, Ross I; Hacker, Fred; Ionascu, Dan; Mamon, Harvey J  (2007). Clinical feasibility of using an EPID in CINE mode for image-guided verification of stereotactic body radiotherapy. International journal of radiation oncology, biology, physics, 69 (1) , 258-66More Information

Ionascu, Dan; Gruia, Flaviu; Ye, Xiong; Yu, Anchi; Rosca, Florin; Beck, Chris; Demidov, Andrey; Olson, John S; Champion, Paul M  (2005). Temperature-dependent studies of NO recombination to heme and heme proteins. Journal of the American Chemical Society, 127 (48) , 16921-34More Information

Ye, Xiong; Yu, Anchi; Georgiev, Georgi Y; Gruia, Florin; Ionascu, Dan; Cao, Wenxiang; Sage, J Timothy; Champion, Paul M  (2005). CO rebinding to protoheme: investigations of the proximal and distal contributions to the geminate rebinding barrier. Journal of the American Chemical Society, 127 (16) , 5854-61More Information

Champion, Paul M; Rosca, Florin; Ionascu, Dan; Cao, Wenxiang; Ye, Xiong  (2004). Rapid timescale processes and the role of electronic surface coupling in the photolysis of diatomic ligands from heme proteins. Faraday discussions, 127, 123-35

Killoran, Joseph H; Gerbaudo, Victor H; Mamede, Marcelo; Ionascu, Dan; Park, Sang-June; Berbeco, Ross  (2011). Motion artifacts occurring at the lung/diaphragm interface using 4D CT attenuation correction of 4D PET scans. Journal of applied clinical medical physics, 12 (4) , 3502More Information

Gruia, Flaviu; Kubo, Minoru; Ye, Xiong; Ionascu, Dan; Lu, Changyuan; Poole, Robert K; Yeh, Syun-Ru; Champion, Paul M  (2008). Coherence spectroscopy investigations of the low-frequency vibrations of heme: effects of protein-specific perturbations. Journal of the American Chemical Society, 130 (15) , 5231-44More Information

Sertorio, Mathieu; Nowrouzi, Ali; Akbarpour, Mahdi; Chetal, Kashish; Salomonis, Nathan; Brons, Stephan; Mascia, Anthony; Ionascu, Dan; Shelby McCauley, ; Kupneski, Taylor; Köthe, Andreas; Debus, Jürgen; Perentesis, John P; Abdollahi, Amir; Zheng, Yi; Wells, Susanne I  (2020). Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and OncologyMore Information

Pomeranz Krummel, Daniel A; Nasti, Tahseen H; Kaluzova, Milota; Kallay, Laura; Bhattacharya, Debanjan; Melms, Johannes C; Izar, Benjamin; Xu, Maxwell; Burnham, Andre; Ahmed, Taukir; Li, Guanguan; Lawson, David; Kowalski, Jeanne; Cao, Yichun; Switchenko, Jeffrey M; Ionascu, Dan; Cook, James M; Medvedovic, Mario; Jenkins, Andrew; Khan, Mohammad K; Sengupta, Soma  (2020). Melanoma Cell Intrinsic GABAA Receptor Enhancement Potentiates Radiation and Immune Checkpoint Inhibitor Response by Promoting Direct and T Cell-Mediated Antitumor Activity. International journal of radiation oncology, biology, physicsMore Information

Dhou, Salam; Lewis, John; Cai, Weixing; Ionascu, Dan; Williams, Christopher  (2020). Quantifying day-to-day variations in 4DCBCT-based PCA motion models. Biomedical physics & engineering express, 6 (3) , 035020More Information

Dhou, Salam; Alkhodari, Mohanad; Ionascu, Dan; Williams, Christopher; Lewis, John H  (2022). Fluoroscopic 3D Image Generation from Patient-Specific PCA Motion Models Derived from 4D-CBCT Patient Datasets: A Feasibility Study. Journal of imaging, 8 (2) More Information

Kennedy, Sonya R; Lafond, Maxime; Haworth, Kevin J; Escudero, Daniel Suarez; Ionascu, Dan; Frierson, Brion; Huang, Shaoling; Klegerman, Melvin E; Peng, Tao; McPherson, David D; Genstler, Curtis; Holland, Christy K  (2023). Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter. Scientific reports, 13 (1) , 6191More Information

Bhattacharya, Debanjan; Barrile, Riccardo; Toukam, Donatien Kamdem; Gawali, Vaibhavkumar S; Kallay, Laura; Ahmed, Taukir; Brown, Hawley; Rezvanian, Sepideh; Karve, Aniruddha; Desai, Pankaj B; Medvedovic, Mario; Wang, Kyle; Ionascu, Dan; Harun, Nusrat; Vallabhapurapu, Subrahmanya; Wang, Chenran; Qi, Xiaoyang; Baschnagel, Andrew M; Kritzer, Joshua A; Cook, James M; Pomeranz Krummel, Daniel A; Sengupta, Soma  (2024). GABA(A) Receptor Activation Drives GABARAP-Nix Mediated Autophagy to Radiation-Sensitize Primary and Brain-Metastatic Lung Adenocarcinoma Tumors. Cancers, 16 (18) More Information

Chimote, Ameet A; Lehn, Maria A; Bhati, Jay; Mascia, Anthony E; Sertorio, Mathieu; Lamba, Michael A; Ionascu, Dan; Tang, Alice L; Langevin, Scott M; Khodoun, Marat V; Wise-Draper, Trisha M; Conforti, Laura  (2024). Proton Treatment Suppresses Exosome Production in Head and Neck Squamous Cell Carcinoma. Cancers, 16 (5) More Information

Bhattacharya, Debanjan; Barille, Riccardo; Toukam, Donatien Kamdem; Gawali, Vaibhavkumar S; Kallay, Laura; Ahmed, Taukir; Brown, Hawley; Rezvanian, Sepideh; Karve, Aniruddha; Desai, Pankaj B; Medvedovic, Mario; Wang, Kyle; Ionascu, Dan; Harun, Nusrat; Wang, Chenran; Baschnagel, Andrew M; Kritzer, Joshua A; Cook, James M; Pomeranz Krummel, Daniel A; Sengupta, Soma  (2023). GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors. bioRxiv : the preprint server for biologyMore Information

American Association of Physicists in Medicine (Workgroup on Treatment Planning (WGTP) ) Committee Member Type:Service to Professional Associations Level:National 04-18-2018 -12-31-2020

American Association of Physicists in Medicine (Working Group on a Professional Doctorate Degree for Medical Physics (WGPDMP) ) Committee Member Type:Service to Professional Associations Level:National 05-28-2019 -12-31-2021

2004 -To Present: Member American Association of Physicists in Medicine (AAPM),

US8539948 Hyperthermia Assisted Radiation Therapy Dan Ionascu, Brian Marples, Di Yan, Alvaro Martinez , Awarded 09-24-2013 Inventor

Academic - Department of Radiation Oncology
3188 Bellevue Ave. ML0757
Cincinnati  Ohio, 45219
Phone: 513-558-4342
Fax: 513-584-4007
dan.ionascu@uc.edu