Research Support
Grant: #Kids Beating Cancer Investigators:Ishikawa, Chiharu 05-15-2023 -09-30-2023 Kids Beating Cancer UBE2N is a Druggable Target and an Essential Ubiquitin-Conjugating Enzyme in Acute Myeloid Leukemia Role:PI 7000.00 Awarded Level:Non Profit
Publications
Peer Reviewed Publications
Muto, Tomoya; Walker, Callum S; Agarwal, Puneet; Vick, Eric; Sampson, Avery; Choi, Kwangmin; Niederkorn, Madeline; Ishikawa, Chiharu; Hueneman, Kathleen; Varney, Melinda; Starczynowski, Daniel T (2023. ) Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation.Haematologica, , 108 (10 ) ,2715-2729 More Information
Bennett, Joshua; Ishikawa, Chiharu; Agarwal, Puneet; Yeung, Jennifer; Sampson, Avery; Uible, Emma; Vick, Eric; Bolanos, Lyndsey C; Hueneman, Kathleen; Wunderlich, Mark; Kolt, Amal; Choi, Kwangmin; Volk, Andrew; Greis, Kenneth D; Rosenbaum, Jan; Hoyt, Scott B; Thomas, Craig J; Starczynowski, Daniel T (2023. ) Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML.Blood, , 142 (11 ) ,989-1007 More Information
Dean, Sarai T; Ishikawa, Chiharu; Zhu, Xiaoqin; Walulik, Sean; Nixon, Timothy; Jordan, Jessica K; Henderson, Samantha; Wyder, Michael; Salomonis, Nathan; Wunderlich, Mark; Greis, Kenneth D; Starczynowski, Daniel T; Volk, Andrew G (2023. ) Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development.Blood advances, , 7 (17 ) ,4822-4837 More Information
Barreyro, Laura; Sampson, Avery M; Ishikawa, Chiharu; Hueneman, Kathleen M; Choi, Kwangmin; Pujato, Mario A; Chutipongtanate, Somchai; Wyder, Michael; Haffey, Wendy D; O'Brien, Eric; Wunderlich, Mark; Ramesh, Vighnesh; Kolb, Ellen M; Meydan, Cem; Neelamraju, Yaseswini; Bolanos, Lyndsey C; Christie, Susanne; Smith, Molly A; Niederkorn, Madeline; Muto, Tomoya; Kesari, Santosh; Garrett-Bakelman, Francine E; Bartholdy, Boris; Will, Britta; Weirauch, Matthew T; Mulloy, James C; Gul, Zartash; Medlin, Stephen; Kovall, Rhett A; Melnick, Ari M; Perentesis, John P; Greis, Kenneth D; Nurmemmedov, Elmar; Seibel, William L; Starczynowski, Daniel T (2022. ) Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia.Science translational medicine, , 14 (635 ) ,eabb7695 More Information
Niederkorn, Madeline; Ishikawa, Chiharu; M Hueneman, Kathleen; Bartram, James; Stepanchick, Emily; R Bennett, Joshua; E Culver-Cochran, Ashley; Bolanos, Lyndsey C; Uible, Emma; Choi, Kwangmin; Wunderlich, Mark; Perentesis, John P; M Chlon, Timothy; Filippi, Marie-Dominique; Starczynowski, Daniel T (2022. ) The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia.Leukemia, , 36 (2 ) ,438-451 More Information