Research and Practice Interests
The overall aim of Dr. Jaeschke's laboratory is to investigate the role of stress-activated protein kinases in metabolic signal transduction. Metabolic syndrome, which is associated with obesity, insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD), is a major health problem world-wide.
The cJun-NH2-stress-activated kinase (JNK) pathway is emerging as important player in the development of obesity-induced insulin resistance and NAFLD.
The major goal is to obtain deeper knowledge of the mechanism by which obesity regulates the JNK pathway and how this pathway is involved in the control of metabolic diseases. This information will provide the basis for the design of rational therapeutic strategies for the control of metabolic diseases.
The methods that the lab is using include recombinant DNA technology, general biochemical techniques, cell culture and knock-out mice.
Positions and Work Experience
- Assistant Professor, Department of Pathology and Laboratory Medicine, Metabolic Disease Institute Cincinnati - GRIA 249
Research Support
Grant: #R01 DK082583 Investigators:Jaeschke, Anja 08-01-2010 -07-31-2015 National Institute of Diabetes and Digestive and Kidney Diseases MLK3 in Metabolic Stress Signaling Role:PI Active 006991-001 Level:Federal
Grant: #R01 DK092138 Investigators:Davidson, William; Jaeschke, Anja; Ji, Yong; Tso, Patrick P.W.; Welge, Jeffrey 07-01-2011 -05-31-2015 National Inst of Diabetes and Digestive and Kidney Disease Gut Mucosal Mast Cells are Activated by Fat Absorption: Physiology and Mechanism Role:Collaborator $1,063,499.00 Active Level:Federal
Grant: #R01 HL147403 Investigators:Hui, David; Jaeschke, Anja 04-01-2019 -03-31-2023 National Heart, Lung and Blood Institute ApoE receptor-2 in vascular disease progression and regression Role:Collaborator $701,789.00 Awarded Level:Federal
Grant: #R01HL156954 Investigators:Hui, David; Jaeschke, Anja 12-01-2021 -11-30-2025 National Heart, Lung and Blood Institute Polymorphic ApoE at the crossroad of lipid metabolism & inflammation in atherosclerosis Role:Collaborator 614941.00 Awarded Level:Federal
Publications
Peer Reviewed Publications
Lu, Jing; Borthwick, Faye; Hassanali, Zahra; Wang, Ye; Mangat, Rabban; Ruth, Megan; Shi, Danni; Jaeschke, Anja; Russell, James C; Field, Catherine J; Proctor, Spencer D; Vine, Donna F (2011. ) Chronic dietary n-3 PUFA intervention improves dyslipidaemia and subsequent cardiovascular complications in the JCR:LA- cp rat model of the metabolic syndrome.The British journal of nutrition, , 1-11 More Information
Jaeschke, Anja; Davis, Roger J (2007. ) Metabolic stress signaling mediated by mixed-lineage kinases.Molecular cell, , 27 (3 ) ,498-508 More Information
Hübner, Anette; Jaeschke, Anja; Davis, Roger J (2006. ) Oncogene addiction: role of signal attenuation.Developmental cell, , 11 (6 ) ,752-4 More Information
Jaeschke, Anja; Karasarides, Maria; Ventura, Juan-Jose; Ehrhardt, Anka; Zhang, Chao; Flavell, Richard A; Shokat, Kevan M; Davis, Roger J (2006. ) JNK2 is a positive regulator of the cJun transcription factor.Molecular cell, , 23 (6 ) ,899-911 More Information
Jaeschke, Anja; Davis, Roger J (2006. ) Chemical genetic analysis of signal transduction pathways.Expert opinion on therapeutic targets, , 10 (4 ) ,485-8 More Information
Jaeschke, Anja; Rincón, Mercedes; Doran, Beth; Reilly, Judith; Neuberg, Donna; Greiner, Dale L; Shultz, Leonard D; Rossini, Aldo A; Flavell, Richard A; Davis, Roger J (2005. ) Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.Proceedings of the National Academy of Sciences of the United States of America, , 102 (19 ) ,6931-5 More Information
Brancho, Deborah; Ventura, Juan-Jose; Jaeschke, Anja; Doran, Beth; Flavell, Richard A; Davis, Roger J (2005. ) Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades.Molecular and cellular biology, , 25 (9 ) ,3670-81 More Information
Jaeschke, Anja; Czech, Michael P; Davis, Roger J (2004. ) An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue.Genes & development, , 18 (16 ) ,1976-80 More Information
Brancho, Deborah; Tanaka, Nobuyuki; Jaeschke, Anja; Ventura, Juan-Jose; Kelkar, Nyaya; Tanaka, Yoshinori; Kyuuma, Masanao; Takeshita, Toshikazu; Flavell, Richard A; Davis, Roger J (2003. ) Mechanism of p38 MAP kinase activation in vivo.Genes & development, , 17 (16 ) ,1969-78 More Information
Jaeschke, Anja; Hartkamp, Joerg; Saitoh, Masao; Roworth, Wendy; Nobukuni, Takahiro; Hodges, Angela; Sampson, Julian; Thomas, George; Lamb, Richard (2002. ) Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent.The Journal of cell biology, , 159 (2 ) ,217-24 More Information
Gadang, Vidya; Konaniah, Eddy; Hui, David Y; Jaeschke, Anja (2014. ) Mixed-Lineage Kinase 3 Deficiency Promotes Neointima Formation Through Increased Activation of the RhoA Pathway in Vascular Smooth Muscle Cells.Arteriosclerosis, thrombosis, and vascular biology, , 34 (7 ) ,1429-36 More Information
Ibrahim, Samar H; Gores, Gregory J; Hirsova, Petra; Kirby, Michelle; Miles, Lili; Jaeschke, Anja; Kohli, Rohit (2013. ) Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis.Liver international : official journal of the International Association for the Study of the Liver, , More Information
Gadang, Vidya; Kohli, Rohit; Myronovych, Andriy; Hui, David Y; Perez-Tilve, Diego; Jaeschke, Anja (2013. ) MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet.American journal of physiology. Endocrinology and metabolism, , 305 (4 ) ,E549-56 More Information
Sharma, Manju; Gadang, Vidya; Jaeschke, Anja (2012. ) Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity.Molecular pharmacology, , 82 (5 ) ,1001-7 More Information
Cash, James G; Kuhel, David G; Basford, Joshua E; Jaeschke, Anja; Chatterjee, Tapan K; Weintraub, Neal L; Hui, David Y (2012. ) Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress.The Journal of biological chemistry, , 287 (33 ) ,27876-84 More Information
Rebholz, Sandra L; Jones, Thomas; Burke, Katie T; Jaeschke, Anja; Tso, Patrick; D'Alessio, David A; Woollett, Laura A (2012. ) Multiparity leads to obesity and inflammation in mothers and obesity in male offspring.American journal of physiology. Endocrinology and metabolism, , 302 (4 ) ,E449-57 More Information
Sharma, Manju; Urano, Fumihiko; Jaeschke, Anja (2012. ) Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes.Journal of hepatology, , 56 (1 ) ,192-8 More Information
Contact Information
Research - Metabolic Diseases Institute
2120 Galbraith Road
Reading
Ohio, 45215
Phone: (513) 558-3898
anja.jaeschke@uc.edu