Michael Jankowski , PhD

Dr. Jankowski joined the faculty in the Department of Anesthesia/ Division of Pain Management at Cincinnati Children’s Hospital Medical Center and the University of Cincinnati Department of Pediatrics in November of 2011.  He is interested in the molecular mechanisms of sensory neuron plasticity after peripheral injuries.  The lab has two main focuses: peripheral mechanisms of musculoskeletal pain specifically in the context of ischemia and the developmental sensitization of sensory afferents.  Previously, he had been awarded both pre-doctoral (2006) and postdoctoral National Research Service Awards (2008) prior to becoming faculty at the University of Pittsburgh.  Since joining the faculty at Cincinnati Children's, he has been a receipient of the Rita Allen Foundation and American Pain Society award in pain, in addition to receiving an Early Career Award from the International Association for the Study of Pain. He has also received numerous grants from the NINDS, NICHD and NIAMS.  He is currently a member of the Society for Neuroscience, the International Association for the Study of Pain, the Society for Pediatric Anesthesia and the American Pain Society.

Bachelor's Degree: University of Pittsburgh Pittsburgh, PA, 2001 (Neuroscience/ Molecular Biology)

Master's Degree: University of Pittsburgh Pittsburgh, PA, 2003 (Neuroscience)

Doctoral Degree: University of Pittsburgh Pittsburgh, PA, 2006 (Neurobiology)

Postdoctoral Associates: University of Pittsburgh Pittsburgh, PA, 2010

Our lab is interested in the molecular mechanisms of sensory neuron plasticity after peripheral injuries.  We have two main focuses: peripheral mechanisms of musculoskeletal pain specifically in the context of ischemia and the developmental sensitization of sensory afferents. 

03-01-2010 -04-30-2010 Reserach Associate, University of Pittsburgh, Pittsburgh, PA

05-01-2010 -10-31-2011 Research Assistant Professor, University of Pittsburgh, Pittsburgh, PA

11-01-2011 -09-01-2017 Assistant Professor, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

09-01-2017 - Associate Professor, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Grant: #FP00002723 Investigators:Michael Jankowski 09-01-2012 -08-31-2015 Rita Allen Foundation and American Pain Society Molecular Mechanisms Of Musculoskeletal Pain After Ischemic Tissue Injury Role:PI $150000 Completed Type:Grant Level:National

Grant: #FP00002656 Investigators:Michael Jankowski 04-01-2012 -03-31-2013 International Association for the Study of Pain Peripheral mechanisms of musculoskeletal pain after ischemic tissue injury Role:PI $20000 Completed Type:Grant Level:International

Grant: #R01AR064551 Investigators:Jankowski 09-01-2013 -09-01-2018 NIH/NIAMS Mechanisms of muscle afferent sensitization after ischemia Role:PI $1,618,868.00 Active Type:Grant Level:National

Grant: #16POST29750004 Investigators:Queme/Jankowski 07-01-2016 -07-01-2018 American Heart Association Role of GDNF in the dual modulation of nociception and cardiovascular reflexes during peripheral ischemia Role:Sponsor $102,550 Active Type:Fellowship Level:National

Grant: #F31AR068896-01A1 Investigators:Ross/Jankowski 08-01-2016 -08-01-2017 NIH/NIAMS Linking sex differences in cardiovascular reflexes and pain perception Role:Sponsor $72,072 Completed Type:Fellowship Level:National

Investigators:Jankowski 09-01-2015 -09-01-2016 CCHMC Growth Hormone, Pediatric Pain and Sensory Development Role:PI $75,000 Completed Type:Grant Level:Local

Grant: #R03HD0077483 Investigators:Jankowski 08-01-2013 -08-01-2015 NIH/NICHD Mechanisms of postnatal cutaneous afferent development during inflammtion Role:PI $100,000 Completed Level:National

Investigators:Jankowski 08-01-2013 -08-01-2014 CCHMC Developmental plasticity of cutaneous sensory neurons Role:PI $60,000 Completed Type:Grant Level:Local

Grant: #201408610031 Investigators:Liu/Jankowski 07-01-2014 -07-01-2016 China Scholarship Council Afferent mechanisms of neonatal pain development Role:Sponsor $40,800 Completed Type:Grant Level:International

Grant: #R56NS103179 Investigators:Jankowski 09-01-2017 -09-01-2018 NIH/NINDS Sensitization of developing sensory neurons during inflammation Role:PI $350,000 Active Type:Grant Level:National

Peer Reviewed Publications

Jankowski, Michael P; Rau, Kristofer K; Soneji, Deepak J; Ekmann, Katrina M; Anderson, Collene E; Molliver, Derek C; Koerber, H Richard (2012. ) Purinergic receptor P2Y1 regulates polymodal C-fiber thermal thresholds and sensory neuron phenotypic switching during peripheral inflammation.Pain, , 153 (2 ) ,410-9 More Information

Li, Lishi; Rutlin, Michael; Abraira, Victoria E; Cassidy, Colleen; Kus, Laura; Gong, Shiaoching; Jankowski, Michael P; Luo, Wenqin; Heintz, Nathaniel; Koerber, H Richard; Woodbury, C Jeffery; Ginty, David D (2011. ) The functional organization of cutaneous low-threshold mechanosensory neurons.Cell, , 147 (7 ) ,1615-27 More Information

Molliver, Derek C; Rau, Kristofer K; McIlwrath, Sabrina L; Jankowski, Michael P; Koerber, H Richard (2011. ) The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors.Molecular pain, , 7 ,13 More Information

Jankowski, Michael P; Rau, Kristofer K; Soneji, Deepak J; Anderson, Collene E; Koerber, H Richard (2010. ) Enhanced artemin/GFR?3 levels regulate mechanically insensitive, heat-sensitive C-fiber recruitment after axotomy and regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 30 (48 ) ,16272-83 More Information

Koerber, H Richard; McIlwrath, Sabrina L; Lawson, Jeffrey J; Malin, Sacha A; Anderson, Collene E; Jankowski, Michael P; Davis, Brian M (2010. ) Cutaneous C-polymodal fibers lacking TRPV1 are sensitized to heat following inflammation, but fail to drive heat hyperalgesia in the absence of TPV1 containing C-heat fibers.Molecular pain, , 6 ,58 More Information

Rau, Kristofer K; McIlwrath, Sabrina L; Wang, Hong; Lawson, Jeffrey J; Jankowski, Michael P; Zylka, Mark J; Anderson, David J; Koerber, H Richard (2009. ) Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 29 (26 ) ,8612-9 More Information

Jankowski, Michael P; McIlwrath, Sabrina L; Jing, Xiaotang; Cornuet, Pamela K; Salerno, Kathleen M; Koerber, H Richard; Albers, Kathryn M (2009. ) Sox11 transcription factor modulates peripheral nerve regeneration in adult mice.Brain research, , 1256 ,43-54 More Information

Jankowski, Michael P; Lawson, Jeffrey J; McIlwrath, Sabrina L; Rau, Kristofer K; Anderson, Collene E; Albers, Kathryn M; Koerber, H Richard (2009. ) Sensitization of cutaneous nociceptors after nerve transection and regeneration: possible role of target-derived neurotrophic factor signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 29 (6 ) ,1636-47 More Information

Jankowski, Michael P; Sesack, Susan R (2004. ) Prefrontal cortical projections to the rat dorsal raphe nucleus: ultrastructural features and associations with serotonin and gamma-aminobutyric acid neurons.The Journal of comparative neurology, , 468 (4 ) ,518-29 More Information

Pinto, Aline; Jankowski, Michael; Sesack, Susan R (2003. ) Projections from the paraventricular nucleus of the thalamus to the rat prefrontal cortex and nucleus accumbens shell: ultrastructural characteristics and spatial relationships with dopamine afferents.The Journal of comparative neurology, , 459 (2 ) ,142-55 More Information

He, Xuelian; Zhang, Liguo; Queme, Luis F; Liu, Xuezhao; Lu, Andrew; Waclaw, Ronald R; Dong, Xinran; Zhou, Wenhao; Kidd, Grahame; Yoon, Sung-Ok; Buonanno, Andres; Rubin, Joshua B; Xin, Mei; Nave, Klaus-Armin; Trapp, Bruce D; Jankowski, Michael P; Lu, Q Richard (2018. ) A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration.Nature medicine, , 24 (3 ) ,338-351 More Information

Ross, Jessica L; Queme, Luis F; Lamb, Jordan E; Green, Kathryn J; Jankowski, Michael P (2018. ) Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury.Biology of sex differences, , 9 (1 ) ,2 More Information

Queme, Luis F; Ross, Jessica L; Jankowski, Michael P (2017. ) Peripheral Mechanisms of Ischemic Myalgia.Frontiers in cellular neuroscience, , 11 ,419 More Information

Ross, Jessica L; Queme, Luis F; Lamb, Jordan E; Green, Kathryn J; Ford, Zachary K; Jankowski, Michael P (2017. ) Interleukin 1? inhibition contributes to the antinociceptive effects of voluntary exercise on ischemia/reperfusion-induced hypersensitivity.Pain, , More Information

Li, Zhuo; Peng, Yanyan; Hufnagel, Robert B; Hu, Yueh-Chiang; Zhao, Chuntao; Queme, Luis F; Khuchua, Zaza; Driver, Ashley M; Dong, Fei; Lu, Q Richard; Lindquist, Diana M; Jankowski, Michael P; Stottmann, Rolf W; Kao, Winston W Y; Huang, Taosheng (2017. ) Loss of SLC25A46 causes neurodegeneration by affecting mitochondrial dynamics and energy production in mice.Human molecular genetics, , 26 (19 ) ,3776-3791 More Information

Jankowski, Michael P (2017. ) A new role of growth hormone and insulin-like growth factor receptor type 1 in neonatal inflammatory nociception: response to commentary.Pain reports, , 2 (4 ) ,e609 More Information

Jankowski, Michael P; Rau, Kristofer K; Koerber, H Richard (2017. ) Cutaneous TRPM8-expressing sensory afferents are a small population of neurons with unique firing properties.Physiological reports, , 5 (7 ) , More Information

Jankowski, Michael P; Baumbauer, Kyle M; Wang, Ting; Albers, Kathryn M; Davis, Brian M; Koerber, H Richard (2017. ) Cutaneous neurturin overexpression alters mechanical, thermal, and cold responsiveness in physiologically identified primary afferents.Journal of neurophysiology, , 117 (3 ) ,1258-1265 More Information

Liu, Xiaohua; Green, Kathryn J; Ford, Zachary K; Queme, Luis F; Lu, Peilin; Ross, Jessica L; Lee, Frank B; Shank, Aaron T; Hudgins, Renita C; Jankowski, Michael P (2017. ) Growth hormone regulates the sensitization of developing peripheral nociceptors during cutaneous inflammation.Pain, , 158 (2 ) ,333-346 More Information

Lu, Peilin; Hudgins, Renita C; Liu, Xiaohua; Ford, Zachary K; Hofmann, Megan C; Queme, Luis F; Jankowski, Michael Paul Upregulation of P2Y1 in neonatal nociceptors regulates heat and mechanical sensitization during cutaneous inflammation.Molecular pain, , 13 ,1744806917730255 More Information

Molliver, Derek C; Rau, Kristofer K; Jankowski, Michael P; Soneji, Deepak J; Baumbauer, Kyle M; Koerber, H Richard (2016. ) Deletion of the murine ATP/UTP receptor P2Y2 alters mechanical and thermal response properties in polymodal cutaneous afferents.Neuroscience, , 332 ,223-30 More Information

Wu, Lai Man Natalie; Wang, Jincheng; Conidi, Andrea; Zhao, Chuntao; Wang, Haibo; Ford, Zachary; Zhang, Liguo; Zweier, Christiane; Ayee, Brian G; Maurel, Patrice; Zwijsen, An; Chan, Jonah R; Jankowski, Michael P; Huylebroeck, Danny; Lu, Q Richard (2016. ) Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination.Nature neuroscience, , 19 (8 ) ,1060-72 More Information

Ross, Jessica L; Queme, Luis F; Cohen, Elysia R; Green, Kathryn J; Lu, Peilin; Shank, Aaron T; An, Suzie; Hudgins, Renita C; Jankowski, Michael P (2016. ) Muscle IL1? Drives Ischemic Myalgia via ASIC3-Mediated Sensory Neuron Sensitization.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 36 (26 ) ,6857-71 More Information

Queme, Luis F; Ross, Jessica L; Lu, Peilin; Hudgins, Renita C; Jankowski, Michael P (2016. ) Dual Modulation of Nociception and Cardiovascular Reflexes during Peripheral Ischemia through P2Y1 Receptor-Dependent Sensitization of Muscle Afferents.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 36 (1 ) ,19-30 More Information

Pooya, Shabnam; Liu, Xiaona; Kumar, V B Sameer; Anderson, Jane; Imai, Fumiyasu; Zhang, Wujuan; Ciraolo, Georgianne; Ratner, Nancy; Setchell, Kenneth D R; Yoshida, Yutaka; Jankowski, Michael P; Dasgupta, Biplab (2015. ) Corrigendum: The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.Nature communications, , 6 ,6075 More Information

Ross, Jessica L; Queme, Luis F; Shank, Aaron T; Hudgins, Renita C; Jankowski, Michael P (2014. ) Sensitization of group III and IV muscle afferents in the mouse after ischemia and reperfusion injury.The journal of pain : official journal of the American Pain Society, , 15 (12 ) ,1257-70 More Information

Pooya, Shabnam; Liu, Xiaona; Kumar, V B Sameer; Anderson, Jane; Imai, Fumiyasu; Zhang, Wujuan; Ciraolo, Georgianne; Ratner, Nancy; Setchell, Kenneth D R; Yoshida, Yutaka; Yutaka, Yoshida; Jankowski, Michael P; Dasgupta, Biplab (2014. ) The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.Nature communications, , 5 ,4993 More Information

Jankowski, Michael P; Ross, Jessica L; Weber, Jonathon D; Lee, Frank B; Shank, Aaron T; Hudgins, Renita C (2014. ) Age-dependent sensitization of cutaneous nociceptors during developmental inflammation.Molecular pain, , 10 ,34 More Information

Jankowski, Michael P; Rau, Kristofer K; Ekmann, Katrina M; Anderson, Collene E; Koerber, H Richard (2013. ) Comprehensive phenotyping of group III and IV muscle afferents in mouse.Journal of neurophysiology, , 109 (9 ) ,2374-81 More Information

Jankowski, Michael P; Soneji, Deepak J; Ekmann, Katrina M; Anderson, Collene E; Koerber, H Richard (2012. ) Dynamic changes in heat transducing channel TRPV1 expression regulate mechanically insensitive, heat sensitive C-fiber recruitment after axotomy and regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 32 (49 ) ,17869-73 More Information

Book Chapter

Michael P Jankowski and H Richard Koerber (2009 ) Neurotrophic factors and Nociceptor Sensitization Translational Pain Research: From Mice to Men .(pp. 31).CRC Press (Author)

Invited Presentations

Michael Jankowski (2008. ) Preparation and Delivery of siRNAs to Sensory Neurons .IASP Satelite Symposium, Edinburgh, Scotland. Professional Meeting. . Level:International

Michael Jankowski (2009. ) Interfering with the molecular mechansisms of pain .CNUP Retreat, Olgebay Resort, Wheeling WV. Professional Meeting. . Level:Regional

Michael Jankowski (03-05-2018. ) (In Press. ) Muscle Pain Mechanisms: Its time to dive deep .American Pain Society, Anaheim, CA. Conference. . Level:National

Michael Jankowski Other speaking engagements available upon request .

2000 -2000 NIMH Research Fellowship Status:Recipient Level:National Type:Fellowship

2000 -2000 Brackenridge Research Fellowship Status:Recipient Level:University Type:Fellowship

2003 -2004 Predoctoral Training in Basic Neuroscience Status:Recipient Level:National Type:Fellowship

2006 -2006 Ruth L Kirschstein National Research Service Award (Predoctoral) Status:Recipient Level:National Type:Grant

2008 -2010 Ruth L Kirschstein National Research Service Award (Postdoctoral) Status:Recipient Level:National Type:Grant

04-01-2012 -03-31-2013 IASP Early Career Research Grant Status:Recipient Level:International Type:Grant

09-01-2012 -08-31-2015 Rita Allen Foundation and American Pain Society Award in Pain Status:Recipient Level:National Type:Grant

Trustee Scholar CCHMC Status:Recipient Level:Local Type:Recognition

09-01-2010 IASP Travel Award Level:International Type:Monetary

Other awards available upon request

Lauren Miller (Undergrad ) Advisor Status:Completed 04-01-2012

Elysia Cohen (Undergrad ) Advisor Status:Completed 08-03-2012

Jon Weber (Doctoral ) Advisor Status:In Progress

Frank Lee (Undergrad ) Advisor Status:Completed

Suzie An (Undergrad ) Advisor Status:Completed

Bhavana Katragadda (Undergrad ) Advisor Status:Completed

Jordan Lamb (Undergrad ) Advisor Status:Completed

Kathryn Green (Undergrad ) Advisor Status:Completed

Sarah Selig (Doctoral ) Advisor Status:Completed

Kimberly Kraus (Doctoral ) Advisor Status:Completed

Evan Purvis (Undergrad ) Advisor Status:Completed

Alex Weyler (Undergrad ) Advisor Status:In Progress

Carolyn McCrossan (Undergrad ) Advisor Status:Completed

Zachary Ford (Doctoral ) Advisor Status:Completed

Adam Dourson (Doctoral ) Advisor Status:In Progress

Jessica Ross, PhD (Doctoral ) Advisor Status:Completed

Xiaohua Liu, PhD (Postdoctoral ) Advisor Status:Completed

Peilin Lu, MD (Postdoctoral ) Advisor Status:Completed

Luis Queme, MD, PhD (Postdoctoral ) Advisor Status:In Progress

Pain Associate Editor Type:Editorial Service Level:International

Molecular Pain Editorial Board Member Type:Editorial Service Level:International

List of other 21 journals to which review was provided is available upon request Type:Editorial Service

NIH (Neurodifferentiation, Plasticity and Regeneration Study Section ) Reviewer Type:Grant Panel Level:National

List 5 other grant review panels available upon request Type:Grant Panel

American Pain Society (Websitew ) Committee Chair Type:Service to Professional Associations Level:National

American Pain Society (Basic Science SIG ) Committee Chair Type:Service to Professional Associations Level:National

Rita Allen Foundation (Scientific Program COmmittee ) Committee Member Type:Service to Professional Associations Level:National

Cincinnati Children's Hospital Medical Center (Cross Departmental Research Council ) Committee Member Type:University/College Service Level:Local 02-01-2018

15/349,651 15/349,651 Growth Hormone to Treat Pediatric Pain Jankowski/ Liu/ Rose, Filed Inventor

Academic - Cincinnati Children's Hospital Medical Center
3333 Burnet Ave
Cincinnati  Ohio, 45229
Phone: 5138037966
michael.jankowski@cchmc.org