Anil Jegga

Anil Jegga

Research Professor-Affiliate

Childrens Hospital Bldg R

232

COM Pediatrics Biomedical Informatics - 0054

Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio 45229

Professional Summary

My long term goals are to design and develop novel and robust computational approaches that will accelerate the diffusion of genomics into biomedical research and education and convert the genomics’ data deluge into systematized knowledge to understand the molecular basis of disease. To this effect I have pioneered approaches and applications in bioinformatics for elucidation of gene regulatory networks (e.g., predict and score p53 target genes, analyzing p53-microRNA networks), understanding the functional impact of coding and noncoding polymorphisms in cancer, systems analyses of disease and drug repositioning. Recently, we have developed a novel systems biology based approach (ToppGene Suite) integrating as many as 17 different parameters to identify and prioritize novel disease and drug target candidate genes.

Our specific areas of interest and expertise are:

  • Gene Regulatory Networks
  • Systems Biology of Disease and Drug Response
  • Biological Network Analysis
  • Drug Discovery and Drug Repositioning

Education

Master's Degree , University of York (Bioinformatics)

Doctor of Veterinary Medicine, College of Veterinary Sciences (Veterinary sciences)

Research and Practice Interests

My long term goals are to design and develop novel and robust computational approaches that will accelerate the diffusion of genomics into biomedical research and education and convert the genomics’ data deluge into systematized knowledge to understand the molecular basis of disease and facilitate translational research. To this effect I have pioneered approaches and applications in bioinformatics for elucidation of gene regulatory networks (e.g., predict and score p53 target genes, analyzing p53-microRNA networks), understanding the functional impact of coding and noncoding polymorphisms in cancer, systems analyses of disease and drug repositioning. Recently, we have developed a novel systems biology based approach (ToppGene Suite) integrating as many as 17 different parameters to identify and prioritize novel disease and drug target candidate genes.

Research Support

Grant: #1R21HL135368-01 Investigators:Anil Jegga 01-01-2017 -12-31-2018 NIH Discovery and characterization of candidate therapeutics for drug-induced pulmonary disease Role:PI Active Type:Grant Level:National

Grant: #1R21-HL133539 Investigators:Anil Jegga and Satish Madala 07-05-2016 -06-30-2018 NIH Integrative analysis of multi-omics data to target fibroblast activation in IPF Role:Co-PI Active Type:Grant

Publications

Peer Reviewed Publications

Wang, Yunguan; Yella, Jaswanth; Chen, Jing; McCormack, Francis X; Madala, Satish K; Jegga, Anil G (2017. ) Unsupervised gene expression analyses identify IPF-severity correlated signatures, associated genes and biomarkers.BMC pulmonary medicine, , 17 (1 ) ,133

Luo, Zhenhua; Jegga, Anil G; Bezerra, Jorge A (2017. ) Gene-disease associations identify a connectome with shared molecular pathways in human cholangiopathies.Hepatology (Baltimore, Md.), ,

Angel, P M; Narmoneva, D A; Sewell-Loftin, M K; Munjal, C; Dupuis, L; Landis, B J; Jegga, A; Kern, C B; Merryman, W D; Baldwin, H S; Bressan, G M; Hinton, Robert B (2017. ) Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease.Annals of biomedical engineering, ,

Kurowski, Brad G; Treble-Barna, Amery; Pitzer, Alexis J; Wade, Shari L; Martin, Lisa J; Chima, Ranjit S; Jegga, Anil (2017. ) Applying Systems Biology Methodology To Identify Genetic Factors Possibly Associated with Recovery after Traumatic Brain Injury.Journal of neurotrauma, , 34 (14 ) ,2280-2290

Landis, Benjamin J; Schubert, Jeffrey A; Lai, Dongbing; Jegga, Anil G; Shikany, Amy R; Foroud, Tatiana; Ware, Stephanie M; Hinton, Robert B (2017. ) Exome Sequencing Identifies Candidate Genetic Modifiers of Syndromic and Familial Thoracic Aortic Aneurysm Severity.Journal of cardiovascular translational research, ,

Smith, Eric A; Gole, Boris; Willis, Nicholas A; Soria, Rebeca; Starnes, Linda M; Krumpelbeck, Eric F; Jegga, Anil G; Ali, Abdullah M; Guo, Haihong; Meetei, Amom R; Andreassen, Paul R; Kappes, Ferdinand; Vinnedge, Lisa M Privette; Daniel, Jeremy A; Scully, Ralph; Wiesmüller, Lisa; Wells, Susanne I (2017. ) DEK is required for homologous recombination repair of DNA breaks.Scientific reports, , 7 ,44662

Malek, E; Abdel-Malek, M A Y; Jagannathan, S; Vad, N; Karns, R; Jegga, A G; Broyl, A; van Duin, M; Sonneveld, P; Cottini, F; Anderson, K C; Driscoll, J J (2017. ) Pharmacogenomics and chemical library screens reveal a novel SCF(SKP2) inhibitor that overcomes Bortezomib resistance in multiple myeloma.Leukemia, , 31 (3 ) ,645-653

Munjal, Charu; Jegga, Anil G; Opoka, Amy M; Stoilov, Ivan; Norris, Russell A; Thomas, Craig J; Smith, J Michael; Mecham, Robert P; Bressan, Giorgio M; Hinton, Robert B (2017. ) Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model.Physiological reports, , 5 (5 ) ,

Malavia, Tulsi A; Chaparala, Srilakshmi; Wood, Joel; Chowdari, Kodavali; Prasad, Konasale M; McClain, Lora; Jegga, Anil G; Ganapathiraju, Madhavi K; Nimgaonkar, Vishwajit L (2017. ) Generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data.NPJ schizophrenia, , 3 ,11

Sontake, Vishwaraj; Wang, Yunguan; Kasam, Rajesh K; Sinner, Debora; Reddy, Geereddy B; Naren, Anjaparavanda P; McCormack, Francis X; White, Eric S; Jegga, Anil G; Madala, Satish K (2017. ) Hsp90 regulation of fibroblast activation in pulmonary fibrosis.JCI insight, , 2 (4 ) ,e91454

Lynch, Thomas L; Ismahil, Mohamed Ameen; Jegga, Anil G; Zilliox, Michael J; Troidl, Christian; Prabhu, Sumanth D; Sadayappan, Sakthivel (2017. ) Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation.Journal of molecular and cellular cardiology, , 102 ,83-93

Singh, Brijendra; Jegga, Anil G; Shanmukhappa, Kumar S; Edukulla, Ramakrishna; Khurana Hershey, Gurjit H; Medvedovic, Mario; Dillon, Stacey R; Madala, Satish K (2016. ) IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function.PloS one, , 11 (8 ) ,e0161877

Sarangdhar, Mayur; Tabar, Scott; Schmidt, Charles; Kushwaha, Akash; Shah, Krish; Dahlquist, Jeanine E; Jegga, Anil G; Aronow, Bruce J (2016. ) Data mining differential clinical outcomes associated with drug regimens using adverse event reporting data.Nature biotechnology, , 34 (7 ) ,697-700

Bian, Fenghua; Gao, Fei; Kartashov, Andrey V; Jegga, Anil G; Barski, Artem; Das, Sanjoy K (2016. ) Polycomb repressive complex 1 controls uterine decidualization.Scientific reports, , 6 ,26061

Miethke, Alexander G; Zhang, Wujuan; Simmons, Julia; Taylor, Amy E; Shi, Tiffany; Shanmukhappa, Shiva Kumar; Karns, Rebekah; White, Shana; Jegga, Anil G; Lages, Celine S; Nkinin, Stephenson; Keller, Bradley T; Setchell, Kenneth D R (2016. ) Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice.Hepatology (Baltimore, Md.), , 63 (2 ) ,512-23

Sarangdhar M, Tabar S, Schmidt C, Kushwaha A, Shah K, Dahlquist JE, Jegga AG, Aronow BJ. (2016. ) Data mining differential clinical outcomes associated with drug regimens using adverse event reporting data. Nature Biotechnology, , 34 (7 ) ,697

Adams, Allie K; Bolanos, Lyndsey C; Dexheimer, Phillip J; Karns, Rebekah A; Aronow, Bruce J; Komurov, Kakajan; Jegga, Anil G; Casper, Keith A; Patil, Yash J; Wilson, Keith M; Starczynowski, Daniel T; Wells, Susanne I (2015. ) IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival.Oncotarget, , 6 (41 ) ,43395-407

Hawrylycz, Michael; Miller, Jeremy A; Menon, Vilas; Feng, David; Dolbeare, Tim; Guillozet-Bongaarts, Angela L; Jegga, Anil G; Aronow, Bruce J; Lee, Chang-Kyu; Bernard, Amy; Glasser, Matthew F; Dierker, Donna L; Menche, Jörg; Szafer, Aaron; Collman, Forrest; Grange, Pascal; Berman, Kenneth A; Mihalas, Stefan; Yao, Zizhen; Stewart, Lance; Barabási, Albert-László; Schulkin, Jay; Phillips, John; Ng, Lydia; Dang, Chinh; Haynor, David R; Jones, Allan; Van Essen, David C; Koch, Christof; Lein, Ed (2015. ) Canonical genetic signatures of the adult human brain.Nature neuroscience, , 18 (12 ) ,1832-44

Cha, Jeeyeon; Burnum-Johnson, Kristin E; Bartos, Amanda; Li, Yingju; Baker, Erin S; Tilton, Susan C; Webb-Robertson, Bobbie-Jo M; Piehowski, Paul D; Monroe, Matthew E; Jegga, Anil G; Murata, Shigeo; Hirota, Yasushi; Dey, Sudhansu K (2015. ) Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus.The Journal of biological chemistry, , 290 (24 ) ,15337-49

Edukulla, Ramakrishna; Singh, Brijendra; Jegga, Anil G; Sontake, Vishwaraj; Dillon, Stacey R; Madala, Satish K (2015. ) Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression.The Journal of biological chemistry, , 290 (21 ) ,13510-20

Patchala, Jagadeesh; Jegga, Anil G (2015. ) Concept Modeling-based Drug Repositioning. AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, , 2015 ,222-6

Gilbert, Shila; Nivarthi, Harini; Mayhew, Christopher N; Lo, Yuan-Hung; Noah, Taeko K; Vallance, Jefferson; Rülicke, Thomas; Müller, Mathias; Jegga, Anil G; Tang, Wenjuan; Zhang, Dongsheng; Helmrath, Michael; Shroyer, Noah; Moriggl, Richard; Han, Xiaonan (2015. ) Activated STAT5 confers resistance to intestinal injury by increasing intestinal stem cell proliferation and regeneration.Stem cell reports, , 4 (2 ) ,209-25

Chung, Daesuk; Gao, Fei; Jegga, Anil G; Das, Sanjoy K (2015. ) Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a.Molecular and cellular endocrinology, , 400 ,48-60

Brundage, M E; Tandon, P; Eaves, D W; Williams, J P; Miller, S J; Hennigan, R H; Jegga, A; Cripe, T P; Ratner, N (2014. ) MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1.Oncogene, , 33 (49 ) ,5626-36

Bessho, Kazuhiko; Mourya, Reena; Shivakumar, Pranavkumar; Walters, Stephanie; Magee, John C; Rao, Marepalli; Jegga, Anil G; Bezerra, Jorge A (2014. ) Gene expression signature for biliary atresia and a role for interleukin-8 in pathogenesis of experimental disease.Hepatology (Baltimore, Md.), , 60 (1 ) ,211-23

Wu, Chao; Bardes, Eric E; Jegga, Anil G; Aronow, Bruce J (2014. ) ToppMiR: ranking microRNAs and their mRNA targets based on biological functions and context.Nucleic acids research, , 42 (Web Server issue ) ,W107-13

Feng, Yuliang; Huang, Wei; Meng, Wei; Jegga, Anil G; Wang, Yigang; Cai, Wenfeng; Kim, Ha Won; Pasha, Zeeshan; Wen, Zhili; Rao, Fang; Modi, Rohan M; Yu, Xiyong; Ashraf, Muhammad (2014. ) Heat shock improves Sca-1+ stem cell survival and directs ischemic cardiomyocytes toward a prosurvival phenotype via exosomal transfer: a critical role for HSF1/miR-34a/HSP70 pathway.Stem cells (Dayton, Ohio), , 32 (2 ) ,462-72

Zhu, Cheng; Wu, Chao; Aronow, Bruce J; Jegga, Anil G (2014. ) Computational approaches for human disease gene prediction and ranking.Advances in experimental medicine and biology, , 799 ,69-84

Velu, Chinavenmeni S; Chaubey, Aditya; Phelan, James D; Horman, Shane R; Wunderlich, Mark; Guzman, Monica L; Jegga, Anil G; Zeleznik-Le, Nancy J; Chen, Jianjun; Mulloy, James C; Cancelas, Jose A; Jordan, Craig T; Aronow, Bruce J; Marcucci, Guido; Bhat, Balkrishen; Gebelein, Brian; Grimes, H Leighton (2014. ) Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.The Journal of clinical investigation, , 124 (1 ) ,222-36

Jegga, Anil G (2014. ) Candidate gene discovery and prioritization in rare diseases.Methods in molecular biology (Clifton, N.J.), , 1168 ,295-312

Wu, Chao; Zhu, Cheng; Jegga, Anil G (2014. ) Integrative literature and data mining to rank disease candidate genes.Methods in molecular biology (Clifton, N.J.), , 1159 ,207-26

Bisio, Alessandra; De Sanctis, Veronica; Del Vescovo, Valerio; Denti, Michela A; Jegga, Anil G; Inga, Alberto; Ciribilli, Yari (2013. ) Identification of new p53 target microRNAs by bioinformatics and functional analysis.BMC cancer, , 13 ,552

Bessho, Kazuhiko; Shanmukhappa, Kumar; Sheridan, Rachel; Shivakumar, Pranavkumar; Mourya, Reena; Walters, Stephanie; Kaimal, Vivek; Dilbone, Eric; Jegga, Anil G; Bezerra, Jorge A (2013. ) Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia.BMC systems biology, , 7 ,104

Rajan, Sudarsan; Pena, James R; Jegga, Anil G; Aronow, Bruce J; Wolska, Beata M; Wieczorek, David F (2013. ) Microarray analysis of active cardiac remodeling genes in a familial hypertrophic cardiomyopathy mouse model rescued by a phospholamban knockout.Physiological genomics, , 45 (17 ) ,764-73

Brown, E B; Layne, J E; Zhu, C; Jegga, A G; Rollmann, S M (2013. ) Genome-wide association mapping of natural variation in odour-guided behaviour in Drosophila.Genes, brain, and behavior, , 12 (5 ) ,503-15

Li, Qi; Deleger, Louise; Lingren, Todd; Zhai, Haijun; Kaiser, Megan; Stoutenborough, Laura; Jegga, Anil G; Cohen, Kevin Bretonnel; Solti, Imre (2013. ) Mining FDA drug labels for medical conditions.BMC medical informatics and decision making, , 13 ,53

Sarangdhar, Mayur; Kushwaha, Akash; Dahlquist, Jeanine; Jegga, Anil; Aronow, Bruce (2013. ) Using Systems Biology-based Analysis Approaches to Identify Mechanistically Significant Adverse Drug Reactions: Pulmonary Complications from Combined Use of Anti-TNF? Agents and Corticosteroids. AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, , 2013 ,151-5

Wu, Chao; Gudivada, Ranga C; Aronow, Bruce J; Jegga, Anil G (2013. ) Computational drug repositioning through heterogeneous network clustering.BMC systems biology, , 7 Suppl 5 ,S6

Deleger, Louise; Molnar, Katalin; Savova, Guergana; Xia, Fei; Lingren, Todd; Li, Qi; Marsolo, Keith; Jegga, Anil; Kaiser, Megan; Stoutenborough, Laura; Solti, Imre (2013. ) Large-scale evaluation of automated clinical note de-identification and its impact on information extraction.Journal of the American Medical Informatics Association : JAMIA, , 20 (1 ) ,84-94

Xie, Huirong; Sun, Xiaofei; Piao, Yulan; Jegga, Anil G; Handwerger, Stuart; Ko, Minoru S H; Dey, Sudhansu K (2012. ) Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration.The Journal of biological chemistry, , 287 (38 ) ,32288-97

Park, Ji Kwon; Martin, Lisa J; Zhang, Xue; Jegga, Anil G; Benson, D Woodrow (2012. ) Genetic variants in SCN5A promoter are associated with arrhythmia phenotype severity in patients with heterozygous loss-of-function mutation.Heart rhythm, , 9 (7 ) ,1090-6

Willson, Tara A; Kuhn, Benjamin R; Jurickova, Ingrid; Gerad, Shaina; Moon, David; Bonkowski, Erin; Carey, Rebecca; Collins, Margaret H; Xu, Huan; Jegga, Anil G; Guthery, Stephen L; Denson, Lee A (2012. ) STAT3 genotypic variation and cellular STAT3 activation and colon leukocyte recruitment in pediatric Crohn disease.Journal of pediatric gastroenterology and nutrition, , 55 (1 ) ,32-43

Zhu, Cheng; Kushwaha, Akash; Berman, Kenneth; Jegga, Anil G (2012. ) A vertex similarity-based framework to discover and rank orphan disease-related genes.BMC systems biology, , 6 Suppl 3 ,S8

Ren, Jie; Jegga, Anil G; Zhang, Minlu; Deng, Jingyuan; Liu, Junbo; Gordon, Christopher B; Aronow, Bruce J; Lu, Long J; Zhang, Bo; Ma, Jun (2011. ) A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome.Human molecular genetics, , 20 (17 ) ,3424-36

Sardana, Divya; Zhu, Cheng; Zhang, Minlu; Gudivada, Ranga C; Yang, Lun; Jegga, Anil G (2011. ) Drug repositioning for orphan diseases.Briefings in bioinformatics, , 12 (4 ) ,346-56

Zhang, Minlu; Zhu, Cheng; Jacomy, Alexis; Lu, Long J; Jegga, Anil G (2011. ) The orphan disease networks.American journal of human genetics, , 88 (6 ) ,755-766

Jegga, Anil G; Schneider, Lonnie; Ouyang, Xiaosen; Zhang, Jianhua (2011. ) Systems biology of the autophagy-lysosomal pathway. Autophagy, , 7 (5 ) ,477-89

Rankin, Scott A; Kormish, Jay; Kofron, Matt; Jegga, Anil; Zorn, Aaron M (2011. ) A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer.Developmental biology, , 351 (2 ) ,297-310

Yang, Lun; Wang, Ke-Jian; Wang, Li-Shan; Jegga, Anil G; Qin, Sheng-Ying; He, Guang; Chen, Jian; Xiao, Yue; He, Lin (2011. ) Chemical-protein interactome and its application in off-target identification.Interdisciplinary sciences, computational life sciences, , 3 (1 ) ,22-30

Yang, Lun; Wang, Kejian; Chen, Jian; Jegga, Anil G; Luo, Heng; Shi, Leming; Wan, Chunling; Guo, Xizhi; Qin, Shengying; He, Guang; Feng, Guoyin; He, Lin (2011. ) Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case study.PLoS computational biology, , 7 (3 ) ,e1002016

Kaimal, Vivek; Sardana, Divya; Bardes, Eric E; Gudivada, Ranga Chandra; Chen, Jing; Jegga, Anil G (2011. ) Integrative systems biology approaches to identify and prioritize disease and drug candidate genes.Methods in molecular biology (Clifton, N.J.), , 700 ,241-59

Ma, Xinghong; Gao, Fei; Rusie, Allison; Hemingway, Jennifer; Ostmann, Alicia B; Sroga, Julie M; Jegga, Anil G; Das, Sanjoy K (2011. ) Decidual cell polyploidization necessitates mitochondrial activity.PloS one, , 6 (10 ) ,e26774

Zhang M, Zhu C, Jacomy A, Lu LJ, Jegga AG. (2011. ) The orphan disease networks. Am J Hum Genet., , 88 (6 ) ,755

Sardana D, Zhu C, Zhang M, Gudivada RC, Yang L, Jegga AG. (2011. ) Drug repositioning for orphan diseases. Brief Bioinform., , 12 (4 ) ,346

Zhang, Xiaowei; Wang, Xiaohong; Zhu, Hongyan; Zhu, Cheng; Wang, Yigang; Pu, William T; Jegga, Anil G; Fan, Guo-Chang (2010. ) Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death.Journal of molecular and cellular cardiology, , 49 (5 ) ,841-50

Maldonado, Arturo R; Klanke, Chuck; Jegga, Anil G; Aronow, Bruce J; Mahller, Yonatan Y; Cripe, Timothy P; Crombleholme, Timothy M (2010. ) Molecular engineering and validation of an oncolytic herpes simplex virus type 1 transcriptionally targeted to midkine-positive tumors.The journal of gene medicine, , 12 (7 ) ,613-23

Sardana, Divya; Vasa, Suresh; Vepachedu, Nishanth; Chen, Jing; Gudivada, Ranga Chandra; Aronow, Bruce J; Jegga, Anil G (2010. ) PhenoHM: human-mouse comparative phenome-genome server.Nucleic acids research, , 38 (Web Server issue ) ,W165-74

Kaimal, Vivek; Bardes, Eric E; Tabar, Scott C; Jegga, Anil G; Aronow, Bruce J (2010. ) ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems.Nucleic acids research, , 38 (Web Server issue ) ,W96-102

Moyer, Katie; Kaimal, Vivek; Pacheco, Cristina; Mourya, Reena; Xu, Huan; Shivakumar, Pranavkumar; Chakraborty, Ranajit; Rao, Marepalli; Magee, John C; Bove, Kevin; Aronow, Bruce J; Jegga, Anil G; Bezerra, Jorge A (2010. ) Staging of biliary atresia at diagnosis by molecular profiling of the liver.Genome medicine, , 2 (5 ) ,33

Takemoto, Clifford M; Brandal, Stephanie; Jegga, Anil G; Lee, Youl-Nam; Shahlaee, Amir; Ying, Ye; Dekoter, Rodney; McDevitt, Michael A (2010. ) PU.1 positively regulates GATA-1 expression in mast cells.Journal of immunology (Baltimore, Md. : 1950), , 184 (8 ) ,4349-61

Gowrisankar, Sivakumar; Jegga, Anil G (2009. ) Regression based predictor for p53 transactivation.BMC bioinformatics, , 10 ,215

Miller, Shyra J; Jessen, Walter J; Mehta, Tapan; Hardiman, Atira; Sites, Emily; Kaiser, Sergio; Jegga, Anil G; Li, Hua; Upadhyaya, Meena; Giovannini, Marco; Muir, David; Wallace, Margaret R; Lopez, Eva; Serra, Eduard; Nielsen, G Petur; Lazaro, Conxi; Stemmer-Rachamimov, Anat; Page, Grier; Aronow, Bruce J; Ratner, Nancy (2009. ) Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene.EMBO molecular medicine, , 1 (4 ) ,236-48

Chen, Jing; Bardes, Eric E; Aronow, Bruce J; Jegga, Anil G (2009. ) ToppGene Suite for gene list enrichment analysis and candidate gene prioritization.Nucleic acids research, , 37 (Web Server issue ) ,W305-11

Qu, Xiaoyan A; Gudivada, Ranga C; Jegga, Anil G; Neumann, Eric K; Aronow, Bruce J (2009. ) Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships.BMC bioinformatics, , 10 Suppl 5 ,S4

Gu, YuanYuan; Harley, Isaac T W; Henderson, Lindsay B; Aronow, Bruce J; Vietor, Ilja; Huber, Lukas A; Harley, John B; Kilpatrick, Jeffrey R; Langefeld, Carl D; Williams, Adrienne H; Jegga, Anil G; Chen, Jing; Wills-Karp, Marsha; Arshad, S Hasan; Ewart, Susan L; Thio, Chloe L; Flick, Leah M; Filippi, Marie-Dominique; Grimes, H Leighton; Drumm, Mitchell L; Cutting, Garry R; Knowles, Michael R; Karp, Christopher L (2009. ) Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease.Nature, , 458 (7241 ) ,1039-42

Chen, Jing; Aronow, Bruce J; Jegga, Anil G (2009. ) Disease candidate gene identification and prioritization using protein interaction networks.BMC bioinformatics, , 10 ,73

Chen J, Bardes EE, Aronow BJ, Jegga AG. (2009. ) ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res., , 37 ,W305

Jegga AG, Inga A, Menendez D, Aronow BJ, Resnick MA. (2008. ) Functional evolution of the p53 regulatory network through its target response elements. Proc Natl Acad Sci USA., , 105 (3 ) ,944

Kamath, M B; Houston, I B; Janovski, A J; Zhu, X; Gowrisankar, S; Jegga, A G; DeKoter, R P (2008. ) Dose-dependent repression of T-cell and natural killer cell genes by PU.1 enforces myeloid and B-cell identity.Leukemia, , 22 (6 ) ,1214-25

Gudivada, Ranga C; Fu, Yun; Jegga, Anil G; Qu, Xiaoyan A; Neumann, Eric K; Aronow, Bruce J (2008. ) Mining human phenome to investigate modularity of complex disorders. Summit on translational bioinformatics, , 2008 ,31-5

Sinha, Amit U; Kaimal, Vivek; Chen, Jing; Jegga, Anil G (2008. ) Dissecting microregulation of a master regulatory network.BMC genomics, , 9 ,88

Jegga, Anil G; Inga, Alberto; Menendez, Daniel; Aronow, Bruce J; Resnick, Michael A (2008. ) Functional evolution of the p53 regulatory network through its target response elements.Proceedings of the National Academy of Sciences of the United States of America, , 105 (3 ) ,944-9

Brunskill, Eric W; Aronow, Bruce J; Georgas, Kylie; Rumballe, Bree; Valerius, M Todd; Aronow, Jeremy; Kaimal, Vivek; Jegga, Anil G; Yu, Jing; Grimmond, Sean; McMahon, Andrew P; Patterson, Larry T; Little, Melissa H; Potter, S Steven (2008. ) Atlas of gene expression in the developing kidney at microanatomic resolution.Developmental cell, , 15 (5 ) ,781-91

Gudivada, Ranga Chandra; Qu, Xiaoyan A; Chen, Jing; Jegga, Anil G; Neumann, Eric K; Aronow, Bruce J (2008. ) Identifying disease-causal genes using Semantic Web-based representation of integrated genomic and phenomic knowledge.Journal of biomedical informatics, , 41 (5 ) ,717-29

Chen, Jing; Xu, Huan; Aronow, Bruce J; Jegga, Anil G (2007. ) Improved human disease candidate gene prioritization using mouse phenotype.BMC bioinformatics, , 8 ,392

Markey, M P; Bergseid, J; Bosco, E E; Stengel, K; Xu, H; Mayhew, C N; Schwemberger, S J; Braden, W A; Jiang, Y; Babcock, G F; Jegga, A G; Aronow, B J; Reed, M F; Wang, J Y J; Knudsen, E S (2007. ) Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function.Oncogene, , 26 (43 ) ,6307-18

Diwan, Abhinav; Koesters, Andrew G; Odley, Amy M; Pushkaran, Suvarnamala; Baines, Christopher P; Spike, Benjamin T; Daria, Diedre; Jegga, Anil G; Geiger, Hartmut; Aronow, Bruce J; Molkentin, Jeffery D; Macleod, Kay F; Kalfa, Theodosia A; Dorn, Gerald W (2007. ) Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis.Proceedings of the National Academy of Sciences of the United States of America, , 104 (16 ) ,6794-9

Liu, Cong; Aronow, Bruce J; Jegga, Anil G; Wang, Ning; Miethke, Alex; Mourya, Reena; Bezerra, Jorge A (2007. ) Novel resequencing chip customized to diagnose mutations in patients with inherited syndromes of intrahepatic cholestasis.Gastroenterology, , 132 (1 ) ,119-26

Kaiser, Sergio; Park, Young-Kyu; Franklin, Jeffrey L; Halberg, Richard B; Yu, Ming; Jessen, Walter J; Freudenberg, Johannes; Chen, Xiaodi; Haigis, Kevin; Jegga, Anil G; Kong, Sue; Sakthivel, Bhuvaneswari; Xu, Huan; Reichling, Timothy; Azhar, Mohammad; Boivin, Gregory P; Roberts, Reade B; Bissahoyo, Anika C; Gonzales, Fausto; Bloom, Greg C; Eschrich, Steven; Carter, Scott L; Aronow, Jeremy E; Kleimeyer, John; Kleimeyer, Michael; Ramaswamy, Vivek; Settle, Stephen H; Boone, Braden; Levy, Shawn; Graff, Jonathan M; Doetschman, Thomas; Groden, Joanna; Dove, William F; Threadgill, David W; Yeatman, Timothy J; Coffey, Robert J; Aronow, Bruce J (2007. ) Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer.Genome biology, , 8 (7 ) ,R131

Jegga, Anil G; Chen, Jing; Gowrisankar, Sivakumar; Deshmukh, Mrunal A; Gudivada, RangaChandra; Kong, Sue; Kaimal, Vivek; Aronow, Bruce J (2007. ) GenomeTrafac: a whole genome resource for the detection of transcription factor binding site clusters associated with conventional and microRNA encoding genes conserved between mouse and human gene orthologs.Nucleic acids research, , 35 (Database issue ) ,D116-21

Jegga, Anil G; Gowrisankar, Sivakumar; Chen, Jing; Aronow, Bruce J (2007. ) PolyDoms: a whole genome database for the identification of non-synonymous coding SNPs with the potential to impact disease.Nucleic acids research, , 35 (Database issue ) ,D700-6

Miller, Shyra J; Rangwala, Fatima; Williams, Jon; Ackerman, Peter; Kong, Sue; Jegga, Anil G; Kaiser, Sergio; Aronow, Bruce J; Frahm, Silke; Kluwe, Lan; Mautner, Victor; Upadhyaya, Meena; Muir, David; Wallace, Margaret; Hagen, Jussara; Quelle, Dawn E; Watson, Mark A; Perry, Arie; Gutmann, David H; Ratner, Nancy (2006. ) Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.Cancer research, , 66 (5 ) ,2584-91

Jegga, Anil G; Gupta, Ashima; Gowrisankar, Sivakumar; Deshmukh, Mrunal A; Connolly, Steven; Finley, Kevin; Aronow, Bruce J (2005. ) CisMols Analyzer: identification of compositionally similar cis-element clusters in ortholog conserved regions of coordinately expressed genes.Nucleic acids research, , 33 (Web Server issue ) ,W408-11

Vukkadapu, Sankaranand S; Belli, Jenine M; Ishii, Koji; Jegga, Anil G; Hutton, John J; Aronow, Bruce J; Katz, Jonathan D (2005. ) Dynamic interaction between T cell-mediated beta-cell damage and beta-cell repair in the run up to autoimmune diabetes of the NOD mouse.Physiological genomics, , 21 (2 ) ,201-11

Bonizzi, Giuseppina; Bebien, Magali; Otero, Dennis C; Johnson-Vroom, Kirsten E; Cao, Yixue; Vu, Don; Jegga, Anil G; Aronow, Bruce J; Ghosh, Gourisankar; Rickert, Robert C; Karin, Michael (2004. ) Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers.The EMBO journal, , 23 (21 ) ,4202-10

Hutton, John J; Jegga, Anil G; Kong, Sue; Gupta, Ashima; Ebert, Catherine; Williams, Sarah; Katz, Jonathan D; Aronow, Bruce J (2004. ) Microarray and comparative genomics-based identification of genes and gene regulatory regions of the mouse immune system.BMC genomics, , 5 ,82

Livingston, Robert J; von Niederhausern, Andrew; Jegga, Anil G; Crawford, Dana C; Carlson, Christopher S; Rieder, Mark J; Gowrisankar, Sivakumar; Aronow, Bruce J; Weiss, Robert B; Nickerson, Deborah A (2004. ) Pattern of sequence variation across 213 environmental response genes.Genome research, , 14 (10A ) ,1821-31

Zhang, Jianhua; Moseley, Amy; Jegga, Anil G; Gupta, Ashima; Witte, David P; Sartor, Maureen; Medvedovic, Mario; Williams, Sarah S; Ley-Ebert, Cathy; Coolen, Lique M; Egnaczyk, Gregory; Genter, Mary Beth; Lehman, Michael; Lingrel, Jerry; Maggio, John; Parysek, Linda; Walsh, Ryan; Xu, Ming; Aronow, Bruce J (2004. ) Neural system-enriched gene expression: relationship to biological pathways and neurological diseases.Physiological genomics, , 18 (2 ) ,167-83

Kim, Jung-whan; Zeller, Karen I; Wang, Yunyue; Jegga, Anil G; Aronow, Bruce J; O'Donnell, Kathryn A; Dang, Chi V (2004. ) Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays.Molecular and cellular biology, , 24 (13 ) ,5923-36

Genter, Mary Beth; Van Veldhoven, Paul P; Jegga, Anil G; Sakthivel, Bhuvana; Kong, Sue; Stanley, Kristin; Witte, David P; Ebert, Catherine L; Aronow, Bruce J (2003. ) Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system.Physiological genomics, , 16 (1 ) ,67-81

Zeller, Karen I; Jegga, Anil G; Aronow, Bruce J; O'Donnell, Kathryn A; Dang, Chi V (2003. ) An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets.Genome biology, , 4 (10 ) ,R69

Jegga, Anil G; Sherwood, Shawn P; Carman, James W; Pinski, Andrew T; Phillips, Jerry L; Pestian, John P; Aronow, Bruce J (2002. ) Detection and visualization of compositionally similar cis-regulatory element clusters in orthologous and coordinately controlled genes.Genome research, , 12 (9 ) ,1408-17

Warren, Mary Ann; Koshoffer, Amy; Aronow, Bruce J; Jegga, Anil G; Brackenbury, Robert (2002. ) Structure of the 5' portion of the human plakoglobin gene.The Journal of investigative dermatology, , 119 (1 ) ,196-7

Bates, Michael D; Erwin, Christopher R; Sanford, L Philip; Wiginton, Dan; Bezerra, Jorge A; Schatzman, Lynn C; Jegga, Anil G; Ley-Ebert, Cathy; Williams, Sarah S; Steinbrecher, Kris A; Warner, Brad W; Cohen, Mitchell B; Aronow, Bruce J (2002. ) Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis. Gastroenterology, , 122 (5 ) ,1467-82

Takemoto, Clifford M; Lee, Youl-Nam; Jegga, Anil G; Zablocki, Daniella; Brandal, Stephanie; Shahlaee, Amir; Huang, Suming; Ye, Ying; Gowrisankar, Sivakumar; Huynh, Jimmy; McDevitt, Michael A Mast cell transcriptional networks.Blood cells, molecules & diseases, , 41 (1 ) ,82-90

Wang, Yunguan; Yella, Jaswanth; Jegga, Anil G (2019. ) Transcriptomic Data Mining and Repurposing for Computational Drug Discovery.Methods in molecular biology (Clifton, N.J.), , 1903 ,73-95

Sontake, Vishwaraj; Kasam, Rajesh K; Sinner, Debora; Korfhagen, Thomas R; Reddy, Geereddy B; White, Eric S; Jegga, Anil G; Madala, Satish K (2018. ) Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease.JCI insight, , 3 (16 ) ,

Hankey, William; Chen, Zhong; Bergman, Maxwell J; Fernandez, Max O; Hancioglu, Baris; Lan, Xun; Jegga, Anil G; Zhang, Jie; Jin, Victor X; Aronow, Bruce J; Wang, Qianben; Groden, Joanna (2018. ) Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1.Oncotarget, , 9 (58 ) ,31214-31230

Peng, Jiangtong; Li, Yutian; Wang, Xiaohong; Deng, Shan; Holland, Jenna; Yates, Emily; Chen, Jing; Gu, Haitao; Essandoh, Kobina; Mu, Xingjiang; Wang, Boyu; McNamara, Robert K; Peng, Tianqing; Jegga, Anil G; Liu, Tiemin; Nakamura, Takahisa; Huang, Kai; Perez-Tilve, Diego; Fan, Guo-Chang (2018. ) An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR? Ubiquitination.Cell reports, , 23 (12 ) ,3607-3620

Chen, Jing; Xu, Huan; Jegga, Anil; Zhang, Kejian; White, Pete S; Zhang, Ge (2018. ) Novel phenotype-disease matching tool for rare genetic diseases.Genetics in medicine : official journal of the American College of Medical Genetics, ,

Yella, Jaswanth K; Yaddanapudi, Suryanarayana; Wang, Yunguan; Jegga, Anil G (2018. ) Changing Trends in Computational Drug Repositioning.Pharmaceuticals (Basel, Switzerland), , 11 (2 ) ,

Kronk, Charles J; Jegga, Anil (2018. ) GNOMICS: A one-stop shop for biomedical and genomic data. AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, , 2017 ,118-123

Jiang, Alex; Jegga, Anil G (2018. ) Characterizing drug-related adverse events by joint analysis of biomedical and genomic data: A case study of drug-induced pulmonary fibrosis. AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, , 2017 ,91-97

Smith, Eric A; Krumpelbeck, Eric F; Jegga, Anil G; Prell, Malte; Matrka, Marie M; Kappes, Ferdinand; Greis, Kenneth D; Ali, Abdullah M; Meetei, Amom R; Wells, Susanne I (2018. ) The nuclear DEK interactome supports multi-functionality.Proteins, , 86 (1 ) ,88-97

Singh, Brijendra; Jegga, Anil G; Shanmukhappa, Kumar S; Edukulla, Ramakrishna; Khurana Hershey, Gurjit Kaur; Medvedovic, Mario; Dillon, Stacey R; Madala, Satish K (2017. ) Correction: IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function.PloS one, , 12 (1 ) ,e0170446

Contact Information

Academic - Cincinnati Children's Hospital Medical Center
Cincinnati  Ohio, 45229
Phone: 513-636-0261
Fax: 513-636-2056
anil.jegga@cchmc.org