Rulang Jiang

Rulang Jiang

Professor-Affiliate

Childrens Hospital Bldg R

S3.216

COM Pediatrics Dev. Biology - 0054

Cincinnati Children's Hospital Medical Center
Division of Developmental Biology
Cincinnati, Ohio 45229

Education

Bachelor's Degree, Nanjing Normal University

Master's Degree, Chinese Academy of Sciences (Genetics)

Doctoral Degree, Wesleyan University

Research and Practice Interests

Molecular developmental biology.

Publications

Peer Reviewed Publications

Jia, Shihai; Kwon, Hyuk-Jae Edward; Lan, Yu; Zhou, Jing; Liu, Han; Jiang, Rulang (2016. ) Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists.Developmental biology, , 420 (1 ) ,110-119

Xu, Jingyue; Liu, Han; Chai, Ok Hee; Lan, Yu; Jiang, Rulang (2016. ) Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organogenesis.PloS one, , 11 (7 ) ,e0159597

Lan, Yu; Zhang, Nian; Liu, Han; Xu, Jingyue; Jiang, Rulang (2016. ) Golgb1 regulates protein glycosylation and is crucial for mammalian palate development.Development (Cambridge, England), , 143 (13 ) ,2344-55

Xu, Jingyue; Liu, Han; Lan, Yu; Aronow, Bruce J; Kalinichenko, Vladimir V; Jiang, Rulang (2016. ) A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development.PLoS genetics, , 12 (1 ) ,e1005769

Dyment, Nathaniel A; Breidenbach, Andrew P; Schwartz, Andrea G; Russell, Ryan P; Aschbacher-Smith, Lindsey; Liu, Han; Hagiwara, Yusuke; Jiang, Rulang; Thomopoulos, Stavros; Butler, David L; Rowe, David W (2015. ) Gdf5 progenitors give rise to fibrocartilage cells that mineralize via hedgehog signaling to form the zonal enthesis.Developmental biology, , 405 (1 ) ,96-107

Breidenbach, Andrew P; Aschbacher-Smith, Lindsey; Lu, Yinhui; Dyment, Nathaniel A; Liu, Chia-Feng; Liu, Han; Wylie, Chris; Rao, Marepalli; Shearn, Jason T; Rowe, David W; Kadler, Karl E; Jiang, Rulang; Butler, David L (2015. ) Ablating hedgehog signaling in tenocytes during development impairs biomechanics and matrix organization of the adult murine patellar tendon enthesis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society, , 33 (8 ) ,1142-51

Liu, Han; Xu, Jingyue; Liu, Chia-Feng; Lan, Yu; Wylie, Christopher; Jiang, Rulang (2015. ) Whole transcriptome expression profiling of mouse limb tendon development by using RNA-seq.Journal of orthopaedic research : official publication of the Orthopaedic Research Society, , 33 (6 ) ,840-8

Lan, Yu; Xu, Jingyue; Jiang, Rulang (2015. ) Cellular and Molecular Mechanisms of Palatogenesis.Current topics in developmental biology, , 115 ,59-84

Xu, Jingyue; Liu, Han; Park, Joo-Seop; Lan, Yu; Jiang, Rulang (2014. ) Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis.Development (Cambridge, England), , 141 (7 ) ,1442-52

Zhou, Hao; Zou, Shujuan; Lan, Yu; Fei, Wei; Jiang, Rulang; Hu, Jing (2014. ) Smad7 modulates TGF? signaling during cranial suture development to maintain suture patency.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, , 29 (3 ) ,716-24

Lan, Yu; Jia, Shihai; Jiang, Rulang Molecular patterning of the mammalian dentition.Seminars in cell & developmental biology, , 25-26 ,61-70

Zhou, Jing; Gao, Yang; Lan, Yu; Jia, Shihai; Jiang, Rulang (2013. ) Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis.Development (Cambridge, England), , 140 (23 ) ,4709-18

Liu, Han; Lan, Yu; Xu, Jingyue; Chang, Ching-Fang; Brugmann, Samantha A; Jiang, Rulang (2013. ) Odd-skipped related-1 controls neural crest chondrogenesis during tongue development.Proceedings of the National Academy of Sciences of the United States of America, , 110 (46 ) ,18555-60

Zhu, Songsong; Chen, Kan; Lan, Yu; Zhang, Nan; Jiang, Rulang; Hu, Jing (2013. ) Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats.Bone, , 53 (2 ) ,340-9

Jia, Shihai; Zhou, Jing; Gao, Yang; Baek, Jin-A; Martin, James F; Lan, Yu; Jiang, Rulang (2013. ) Roles of Bmp4 during tooth morphogenesis and sequential tooth formation.Development (Cambridge, England), , 140 (2 ) ,423-32

Anderson, Douglas M; George, Rajani; Noyes, Marcus B; Rowton, Megan; Liu, Wenjin; Jiang, Rulang; Wolfe, Scot A; Wilson-Rawls, Jeanne; Rawls, Alan (2012. ) Characterization of the DNA-binding properties of the Mohawk homeobox transcription factor.The Journal of biological chemistry, , 287 (42 ) ,35351-9

Yu, Cheng-Tai; Tang, Ke; Suh, Jae Mi; Jiang, Rulang; Tsai, Sophia Y; Tsai, Ming-Jer (2012. ) COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival.Development (Cambridge, England), , 139 (13 ) ,2330-9

Bush, Jeffrey O; Jiang, Rulang (2012. ) Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development.Development (Cambridge, England), , 139 (2 ) ,231-43

Guillot, Nicolas; Kollins, Dmitrij; Gilbert, Victoria; Xavier, Sandhya; Chen, Jun; Gentle, Madeleine; Reddy, Anand; Bottinger, Erwin; Jiang, Rulang; Rastaldi, Maria Pia; Corbelli, Alessandro; Schlondorff, Detlef (2012. ) BAMBI regulates angiogenesis and endothelial homeostasis through modulation of alternative TGF? signaling.PloS one, , 7 (6 ) ,e39406

Kim, Tak-Heun; Lee, Ju-Yeon; Baek, Jin-A; Lee, Jeong-Chae; Yang, Xiao; Taketo, Makoto M; Jiang, Rulang; Cho, Eui-Sic (2011. ) Constitutive stabilization of ß-catenin in the dental mesenchyme leads to excessive dentin and cementum formation.Biochemical and biophysical research communications, , 412 (4 ) ,549-55

Zhou, Jing; Gao, Yang; Zhang, Zunyi; Zhang, Yuan; Maltby, Kathleen M; Liu, Zhaoyang; Lan, Yu; Jiang, Rulang (2011. ) Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field.Developmental biology, , 353 (2 ) ,344-53

Li, Jingyuan; Huang, Xiaofeng; Xu, Xun; Mayo, Julie; Bringas, Pablo; Jiang, Rulang; Wang, Songling; Chai, Yang (2011. ) SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis.Development (Cambridge, England), , 138 (10 ) ,1977-89

Lan, Yu; Liu, Han; Ovitt, Catherine E; Jiang, Rulang (2011. ) Generation of Osr1 conditional mutant mice.Genesis (New York, N.Y. : 2000), , 49 (5 ) ,419-22

Gao, Yang; Lan, Yu; Liu, Han; Jiang, Rulang (2011. ) The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation.Developmental biology, , 352 (1 ) ,83-91

Baek, Jin-A; Lan, Yu; Liu, Han; Maltby, Kathleen M; Mishina, Yuji; Jiang, Rulang (2011. ) Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation.Developmental biology, , 350 (2 ) ,520-31

Xie, Rong; Jiang, Rulang; Chen, Di (2011. ) Generation of Axin1 conditional mutant mice.Genesis (New York, N.Y. : 2000), , 49 (2 ) ,98-102

Liu, Wenjin; Watson, Spencer S; Lan, Yu; Keene, Douglas R; Ovitt, Catherine E; Liu, Han; Schweitzer, Ronen; Jiang, Rulang (2010. ) The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis.Molecular and cellular biology, , 30 (20 ) ,4797-807

Chen, Jianquan; Lan, Yu; Baek, Jin-A; Gao, Yang; Jiang, Rulang (2009. ) Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development.Developmental biology, , 334 (1 ) ,174-85

Richardson, Rebecca J; Dixon, Jill; Jiang, Rulang; Dixon, Michael J (2009. ) Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence.Human molecular genetics, , 18 (14 ) ,2632-42

Xiong, Wei; He, Fenglei; Morikawa, Yuka; Yu, Xueyan; Zhang, Zunyi; Lan, Yu; Jiang, Rulang; Cserjesi, Peter; Chen, Yiping (2009. ) Hand2 is required in the epithelium for palatogenesis in mice.Developmental biology, , 330 (1 ) ,131-41

Gao, Yang; Lan, Yu; Ovitt, Catherine E; Jiang, Rulang (2009. ) Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development.Developmental biology, , 328 (2 ) ,200-9

Lan, Yu; Jiang, Rulang (2009. ) Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth.Development (Cambridge, England), , 136 (8 ) ,1387-96

Zhang, Zunyi; Lan, Yu; Chai, Yang; Jiang, Rulang (2009. ) Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row.Science (New York, N.Y.), , 323 (5918 ) ,1232-4

Liu, Wenjin; Lan, Yu; Pauws, Erwin; Meester-Smoor, Magda A; Stanier, Philip; Zwarthoff, Ellen C; Jiang, Rulang (2008. ) The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice.Development (Cambridge, England), , 135 (23 ) ,3959-68

Lan, Yu; Wang, Qingru; Ovitt, Catherine E; Jiang, Rulang (2007. ) A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development.Genesis (New York, N.Y. : 2000), , 45 (10 ) ,618-24

Chen, Jianquan; Bush, Jeffrey O; Ovitt, Catherine E; Lan, Yu; Jiang, Rulang (2007. ) The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival.Genesis (New York, N.Y. : 2000), , 45 (8 ) ,482-6

James, Richard G; Kamei, Caramai N; Wang, Qingru; Jiang, Rulang; Schultheiss, Thomas M (2006. ) Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells.Development (Cambridge, England), , 133 (15 ) ,2995-3004

Liu, Han; Liu, Wenjin; Maltby, Kathleen M; Lan, Yu; Jiang, Rulang (2006. ) Identification and developmental expression analysis of a novel homeobox gene closely linked to the mouse Twirler mutation.Gene expression patterns : GEP, , 6 (6 ) ,632-6

Casey, Liam M; Lan, Yu; Cho, Eui-Sic; Maltby, Kathleen M; Gridley, Thomas; Jiang, Rulang (2006. ) Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.Developmental dynamics : an official publication of the American Association of Anatomists, , 235 (7 ) ,1830-44

Lan, Yu; Ryan, Rosemary C; Zhang, Zunyi; Bullard, Steven A; Bush, Jeffrey O; Maltby, Kathleen M; Lidral, Andrew C; Jiang, Rulang (2006. ) Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice.Developmental dynamics : an official publication of the American Association of Anatomists, , 235 (5 ) ,1448-54

Jiang, Rulang; Bush, Jeffrey O; Lidral, Andrew C (2006. ) Development of the upper lip: morphogenetic and molecular mechanisms.Developmental dynamics : an official publication of the American Association of Anatomists, , 235 (5 ) ,1152-66

Knight, Alexandra S; Schutte, Brian C; Jiang, Rulang; Dixon, Michael J (2006. ) Developmental expression analysis of the mouse and chick orthologues of IRF6: the gene mutated in Van der Woude syndrome.Developmental dynamics : an official publication of the American Association of Anatomists, , 235 (5 ) ,1441-7

Wang, Qingru; Lan, Yu; Cho, Eui-Sic; Maltby, Kathleen M; Jiang, Rulang (2005. ) Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development.Developmental biology, , 288 (2 ) ,582-94

Vieira, Alexandre R; Avila, Joseph R; Daack-Hirsch, Sandra; Dragan, Ecaterina; Félix, Têmis M; Rahimov, Fedik; Harrington, Jill; Schultz, Rebecca R; Watanabe, Yoriko; Johnson, Marla; Fang, Jennifer; O'Brien, Sarah E; Orioli, Iêda M; Castilla, Eduardo E; Fitzpatrick, David R; Jiang, Rulang; Marazita, Mary L; Murray, Jeffrey C (2005. ) Medical sequencing of candidate genes for nonsyndromic cleft lip and palate.PLoS genetics, , 1 (6 ) ,e64

Alappat, Sylvia R; Zhang, Zunyi; Suzuki, Kentaro; Zhang, Xiaoyun; Liu, Hongbing; Jiang, Rulang; Yamada, Gen; Chen, YiPing (2005. ) The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice.Developmental biology, , 277 (1 ) ,102-13

Hadland, Brandon K; Huppert, Stacey S; Kanungo, Jyotshnabala; Xue, Yingzi; Jiang, Rulang; Gridley, Thomas; Conlon, Ronald A; Cheng, Alec M; Kopan, Raphael; Longmore, Gregory D (2004. ) A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development.Blood, , 104 (10 ) ,3097-105

Lan, Yu; Ovitt, Catherine E; Cho, Eui-Sic; Maltby, Kathleen M; Wang, Qingru; Jiang, Rulang (2004. ) Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis.Development (Cambridge, England), , 131 (13 ) ,3207-16

Bush, Jeffrey O; Lan, Yu; Jiang, Rulang (2004. ) The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene.Proceedings of the National Academy of Sciences of the United States of America, , 101 (18 ) ,7022-7

Bush, Jeffrey O; Maltby, Kathleen M; Cho, Eui-Sic; Jiang, Rulang (2003. ) The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis. Gene expression patterns : GEP, , 3 (4 ) ,533-8

Krebs, Luke T; Iwai, Naomi; Nonaka, Shigenori; Welsh, Ian C; Lan, Yu; Jiang, Rulang; Saijoh, Yukio; O'Brien, Timothy P; Hamada, Hiroshi; Gridley, Thomas (2003. ) Notch signaling regulates left-right asymmetry determination by inducing Nodal expression.Genes & development, , 17 (10 ) ,1207-12

Bush, Jeffrey O; Lan, Yu; Maltby, Kathleen M; Jiang, Rulang (2002. ) Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene.Developmental dynamics : an official publication of the American Association of Anatomists, , 225 (3 ) ,322-6

Liu Z.;Li C.;Xu J.;Lan Y.;Liu H.;Li X.;Maire P.;Wang X.;Jiang R. (05-01-2019. ) Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development.Journal of Dental Research, , 98 (5 ) ,572-579

Liu H.;Xu J.;Jiang R. (03-01-2019. ) Mkx-Deficient Mice Exhibit Hedgehog Signaling–Dependent Ectopic Ossification in the Achilles Tendons.Journal of Bone and Mineral Research, , 34 (3 ) ,557-569

Xu J.;Liu H.;Lan Y.;Adam M.;Clouthier D.E.;Potter S.;Jiang R. (01-14-2019. ) Hedgehog signaling patterns the oral-aboral axis of the mandibular arch.eLife, , 8 ,

Fu X.;Xu J.;Chaturvedi P.;Liu H.;Jiang R.;Lan Y. (11-01-2017. ) Identification of Osr2 Transcriptional Target Genes in Palate Development.Journal of Dental Research, , 96 (12 ) ,1451-1458

Li C.;Lan Y.;Jiang R. (10-01-2017. ) Molecular and Cellular Mechanisms of Palate Development.Journal of Dental Research, , 96 (11 ) ,1184-1191

Li C.;Lan Y.;Krumlauf R.;Jiang R. (10-01-2017. ) Modulating Wnt Signaling Rescues Palate Morphogenesis in Pax9 Mutant Mice.Journal of Dental Research, , 96 (11 ) ,1273-1281

Kwon H.J.E.;Jia S.;Lan Y.;Liu H.;Jiang R. (09-01-2017. ) Activin and Bmp4 Signaling Converge on Wnt Activation during Odontogenesis.Journal of Dental Research, , 96 (10 ) ,1145-1152

Han L.;Xu J.;Grigg E.;Slack M.;Chaturvedi P.;Jiang R.;Zorn A. (07-01-2017. ) Osr1 functions downstream of Hedgehog pathway to regulate foregut development.Developmental Biology, , 427 (1 ) ,72-83

Kwon H.;Park E.;Jia S.;Liu H.;Lan Y.;Jiang R. (01-01-2015. ) Deletion of Osr2 partially rescues tooth development in Runx2 mutant mice.Journal of Dental Research, , 94 (8 ) ,1113-1119

Bae C.H.;Lee J.Y.;Kim T.H.;Baek J.A.;Lee J.C.;Yang X.;Taketo M.M.;Jiang R.;Cho E.S. (08-01-2013. ) Excessive Wnt/?-catenin signaling disturbs tooth-root formation.Journal of Periodontal Research, , 48 (4 ) ,405-410

Kim T.H.;Bae C.H.;Lee J.C.;Ko S.O.;Yang X.;Jiang R.;Cho E.S. (03-01-2013. ) ?-Catenin is required in odontoblasts for tooth root formation.Journal of Dental Research, , 92 (3 ) ,215-221

Baek J.A.;Lan Y.;Liu H.;Maltby K.M.;Mishina Y.;Jiang R. (02-15-2011. ) Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation.Developmental Biology, , 350 (2 ) ,520-531

Gao Y.;Lan Y.;Liu H.;Jiang R. (01-01-2011. ) The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation.Developmental Biology, , 352 (1 ) ,83-91

Zhou J.;Gao Y.;Zhang Z.;Zhang Y.;Maltby K.;Liu Z.;Lan Y.;Jiang R. (01-01-2011. ) Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmenta.Developmental Biology, , 353 (2 ) ,344-353

Alappat S.;Zhang Z.;Suzuki K.;Zhang X.;Liu H.;Jiang R.;Yamada G.;Chen Y. (01-01-2005. ) The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice.Developmental Biology, , 277 (1 ) ,102-113

Carver E.;Jiang R.;Lan Y.;Oram K.;Gridley T. (11-22-2001. ) The mouse Snail gene encodes a key regulator of the epithelial-mesenchymal transition.Molecular and Cellular Biology, , 21 (23 ) ,8184-8188

McCright B.;Gao X.;Shen L.;Lozier J.;Lan Y.;Maguire M.;Herzlinger D.;Weinmaster G.;Jiang R.;Gridley T. (04-02-2001. ) Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic .Development, , 128 (4 ) ,491-502

Lan Y.;Kingsley P.;Cho E.;Jiang R. (01-01-2001. ) Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns durin.Mechanisms of Development, , 107 (1-2 ) ,175-179

Lanford P.;Lan Y.;Jiang R.;Lindsell C.;Weinmaster G.;Gridley T.;Kelley M. (03-01-1999. ) Notch signalling pathway mediates hair cell development in mammalian cochlea.Nature Genetics, , 21 (3 ) ,289-292

Jiang R.;Norton C.;Copeland N.;Gilbert D.;Jenkins N.;Gridley T. (11-26-1998. ) Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene.Biochimica et Biophysica Acta - Gene Structure and Expression, , 1443 (1-2 ) ,251-254

Bell S.;Lan Y.;Jiang R.;Gridley T. (09-15-1998. ) Exclusion of Jagged2 as a candidate for the legless gene.Mammalian Genome, , 9 (9 ) ,778-779

Jiang R.;Lan Y.;Norton C.;Sundberg J.;Gridley T. (06-15-1998. ) The slug gene is not essential for mesoderm or neural crest development in mice.Developmental Biology, , 198 (2 ) ,277-285

Jiang R.;Lan Y.;Chapman H.;Shawber C.;Norton C.;Serreze D.;Weinmaster G.;Gridley T. (04-01-1998. ) Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice.Genes and Development, , 12 (7 ) ,1046-1057

Lan Y.;Jiang R.;Shawber C.;Weinmaster G.;Gridley T. (11-15-1997. ) The Jagged2 gene maps to chromosome 12 and is a candidate for the igl and l sm mutations .Mammalian Genome, , 8 (11 ) ,875-876

Jiang R.;Copeland N.;Gilbert D.;Jenkins N.;Gridley T. (09-01-1997. ) Genomic organization and chromosomal localization of the mouse snail (Sna) gene.Mammalian Genome, , 8 (9 ) ,686-688

Jiang R.;Gridley T. (05-01-1997. ) Gene targeting: Things go better with Cre .Current Biology, , 7 (5 ) ,

Contact Information

Academic - Cincinnati Children's Hospital Medical Center
Division of Developmental Biology
Cincinnati  Ohio, 45229
Phone: 513-636-3212
rulang.jiang@cchmc.org