Shinsmon Jose, PhD

The focus of my research career has been to study the factors that control beneficial vs. detrimental inflammatory responses to infectious pathogens. I have been studying the innate immune response to a noxious challenge and have contributed to significant advancement in understanding mechanisms that control innate immune responses to pathogens. Work carried out during post-doctoral fellowship at UC has revealed the impact of host genetics, bile acid metabolism, and immune mediators, e.g., macrophage migration inhibitory factor (MIF) and interleukin (IL)-1β, on disease severity after Clostridioides difficile infection. As an Assistant Professor in the infectious disease division, I am focused on elucidating intercellular communication that regulates inflammatory responses to gastrointestinal (GI) infections.

MSc.: Bharathiyar University India, 2006 (Biotechnology)

Ph.D: University Putra Malaysia Kuala Lumpur, 2013 (Immunology)

2014 -2015 Post-doctoral fellow, Universiti Kebangsaan Malaysia, Kuala Lumpur

2016 -2022 Post-doctoral fellow, University of Cincinnati, Cincinnati

2022 -2023 Research Instructor, University of Cincinnati, Cincinnati, Ohio, United States

2023 - Research Assistant Professor, University of Cincinnati, Cincinnati, Ohio, United States

Grant: #VA IPA Jose Investigators:Jose, Shinsmon 07-01-2019 -06-30-2020 Department of Veterans Affairs VA IPA Jose Role:PI $42,885.09 Awarded Level:Federal

Investigators:Shinsmon Jose 01-2022 -01-2023 Department of Internal Medicine, University of Cincinnati Identifying pathogen-derived determinants and cellular sources of Interleukin-1β in CDI Role:PI $30,000 Completed Type:Grant

Grant: #UL1TR001425 Investigators:Shinsmon Jose 04-2023 -03-2025 CCTST UC-NIH Targeted drug delivery to limit luminal neutrophils in Clostridioides difficile infection Role:PI $251,569 Active Type:Grant Level:National

Investigators:Shinsmon Jose 01-05-2025 -01-05-2026 Department of Internal Medicine Junior Faculty Pilot Project Award Role of pathogen heterogeneity in Neutrophil-C. difficile interactions Role:PI $40000 Active Type:Grant Level:Department

Peer Reviewed Publications

Liy, Pan M; Puzi, Nur Nabilah A; Jose, Shinsmon; Vidyadaran, Sharmili (2021. ) Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells.Experimental biology and medicine (Maywood, N.J.), , 246 (22 ) ,2399-2406 More Information

Jose, Shinsmon; Mukherjee, Anindita; Horrigan, Olivia; Setchell, Kenneth D R; Zhang, Wujuan; Moreno-Fernandez, Maria E; Andersen, Heidi; Sharma, Divya; Haslam, David B; Divanovic, Senad; Madan, Rajat (2021. ) Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice.Mucosal immunology, , 14 (2 ) ,500-510 More Information

Horrigan, Olivia; Jose, Shinsmon; Mukherjee, Anindita; Sharma, Divya; Huber, Alexander; Madan, Rajat (2021. ) Leptin Receptor q223r Polymorphism Influences Clostridioides difficile Infection-Induced Neutrophil CXCR2 Expression in an Interleukin-1? Dependent Manner.Frontiers in cellular and infection microbiology, , 11 ,619192 More Information

Huaman, Moises A; Qualls, Joseph E; Jose, Shinsmon; Schmidt, Stephanie M; Moussa, Anissa; Kuhel, David G; Konaniah, Eddy; Komaravolu, Ravi K; Fichtenbaum, Carl J; Deepe, George S; Hui, David Y (2020. ) Mycobacterium bovis Bacille-Calmette-Guérin Infection Aggravates Atherosclerosis.Frontiers in immunology, , 11 ,607957 More Information

Jose, Shinsmon; Mukherjee, Anindita; Abhyankar, Mayuresh M; Leng, Lin; Bucala, Richard; Sharma, Divya; Madan, Rajat (2018. ) Neutralization of macrophage migration inhibitory factor improves host survival after Clostridium difficile infection.Anaerobe, , 53 ,56-63 More Information

Hafez, Pezhman; Chowdhury, Shiplu R; Jose, Shinsmon; Law, Jia Xian; Ruszymah, B H I; Mohd Ramzisham, Abdul Rahman; Ng, Min Hwei (2018. ) Development of an In Vitro Cardiac Ischemic Model Using Primary Human Cardiomyocytes.Cardiovascular engineering and technology, , 9 (3 ) ,529-538 More Information

Jose, S; Abhyankar, M M; Mukherjee, A; Xue, J; Andersen, H; Haslam, D B; Madan, R (2018. ) Leptin receptor q223r polymorphism influences neutrophil mobilization after Clostridium difficile infection.Mucosal immunology, , 11 (3 ) ,947-957 More Information

Jose, Shinsmon; Madan, Rajat (2016. ) Neutrophil-mediated inflammation in the pathogenesis of Clostridium difficile infections.Anaerobe, , 41 ,85-90 More Information

Mathew, Ann M; Huber, Alexander; Sous, Rowis D; Weghorn, Kristin N; Powers-Fletcher, Margaret V; Jose, Shinsmon; Madan, Rajat (2024. ) Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production.The Journal of infectious diseases, , More Information

Book Chapter

Shinsmon Jose, David Terrero-Salcedo, Rajat Madan (2024 ) Clostridioides difficile: from “difficult to grow” to “difficult to treat” Molecular Medical Microbiology (Third Edition) .(pp. 945 --956).Academic Press (Author)

Research - MSB 6105A
231 Albert Sabin Way
Cincinnati  Ohio, 45267
Phone: 513-558-4717
josesn@ucmail.uc.edu