Susan Kasper

Susan Kasper , PhD

Professor

Department of Environmental Health
Kettering Laboratory
Phone 513-558-2126
Email Susan.Kasper@uc.edu

Professional Summary

Susan Kasper, PhD, is Professor of Environmental Health at the University of Cincinnati, College of Medicine. Dr. Kasper received her PhD in Physiology/Endocrinology in the Laboratory of Henry G. Friesen, MD at the University of Manitoba, Winnipeg, Manitoba, Canada and completed a Medical Research Council (MRC) of Canada-funded postdoctoral fellowship in the Dana Farber Cancer Institute, Harvard Medical School and the Department of Molecular Medicine, New England Medical Center Hospitals, Boston, MA. Dr. Kasper joined the Department of Urologic Surgery at the Vanderbilt University Medical Center, Nashville, TN as Research Assistant Professor in 1996, moving to Assistant Professor (tenure track) and subsequently to Associate Professor (tenured) and Professor in the Department of Environmental Health at the University of Cincinnati.
 
Dr. Kasper has developed and currently leads a research program centered on processes that promote prostate cancer development and progression, including androgen receptor signaling, EMT, and signaling pathways which regulate self-renewal, proliferation, survival, adhesion, migration and differentiation of cancer stem cells (CSCs). These studies have received funding from the Department of Defense Prostate Cancer Research Program and NIH/NIDDK. New areas of research include the role of flame retardants as endocrine disruptors (in collaboration with Dr. Adam Biales, Chief at the Internal Exposure Indicators Branch (IEIB), National Exposure Research Laboratory, EPA at Cincinnati) and the role of exosomes in carrying signals that promote cancer/cancer progression (prostate cancer; head and neck cancers (in collaboration with Scott Langevin, PhD).

Education

Bachelor's Degree: University of Manitoba Winnipeg, MB, Canada, 1978 (Zoology)

Master's Degree : University of Manitoba Winnipeg, MB, Canada, 1981 (Physiology/Endocrinology)

Doctoral Degree: University of Manitoba Winnipeg, MB, Canada, 1984 (Physiology/Endocrinology)

Postdoctoral Fellowship: Dana-Farber Cancer Institute Boston, MA, 1987

Postdoctoral Fellowship: New England Medical Center Hospitals Boston, MA, 1989 (Molecular Medicine)

Research and Practice Interests

Research in our laboratory focuses on mechanisms by which prostate cancer becomes metastatic and progresses to therapeutic resistance. Therefore we are interrogating the integration of intrinsic (hormone receptor) and extrinsic (stem cell niche factor, environmental toxicant) signaling pathways in regulating genetic programs that control self-renewal, proliferation, survival, cell adhesion, migration and differentiation of stem/cancer stem cells. We have established several cancer stem cell-like models, including the human prostate HPET and HuSLC cell lines, which are being used to study these processes in vitro and in vivo (mouse xenograft model).
 
A second area of research focuses on Stathmin (Stmn1), a phospho-protein overexpressed in most cancers. Increased Stmn1 expression correlates with disease progression and poor prognostic outcome and is being considered as a potential therapeutic target. Stmn1 activity is tightly regulated by the differential phosphorylation of 4 serines in response to several major signaling pathways. Our study investigates the role(s) of these serines in regulating cell cycle progression, microtubule formation and epithelial mesenchymal transition (EMT) in vitro using a CRISPR approach to generate DU-145 prostate cancer cell lines carrying substitution mutations at these sites alone and in combination, and in vivo using an innovative zebrafish xenograft model. Knowledge on which Stmn1 phospho-forms control PCa cell proliferation and/or metastatic potential in the continuum of PCa progression is critical for the development of rational approaches to treat advanced/metastatic disease.
 
Recently, we have initiated studies in collaboration with Dr. Adam Biales, Chief at the Internal Exposure Indicators Branch (IEIB), National Exposure Research Laboratory, EPA at Cincinnati on the endocrine disrupting activities of Firemaster® 550 (FM550), a new-generation flame-retardant mixture that has replaced TDCPP in polyurethane foam. Trace levels of flame retardants are detected in multiple tissues, including adipose, liver, muscle, skin and blood in most Americans, when tested. Moreover specific populations are at much greater risk of exposure to high levels of flame retardants. An example is firefighters who have been diagnosed with PCa as early as in their 40s and 50s, as compared to the general male population who are on average > 65 years old at the time of diagnosis. Therefore there is a significant need to investigate the endocrine disrupting activities of flame retardants and determine their long-range effects on human health.

Research Support

Grant: #W81XWH-17-1-0601 Investigators:Kasper, Susan 09-30-2017 -09-29-2020 Department of the Army Medical Research Acquisition Activity Stathmin phosphorylation as a target for blocking metastasis in prostate cancer Role:PI $929,662.00 Active Level:Federal

Grant: #R21DE027227 Investigators:Kasper, Susan; Langevin, Scott; Medvedovic, Mario; Wise-Draper, Trisha; Zhang, Xiang 09-01-2017 -08-31-2019 National Institute of Dental and Craniofacial Research Exosomal miRNA as Salivary Biomarkers for HPV+ Head and Neck Carcinoma Role:Collaborator $239,250.00 Awarded Level:Federal

Grant: #R13DK112664 Investigators:Kasper, Susan 09-01-2016 -08-31-2017 National Inst of Diabetes and Digestive and Kidney Disease Urologic Biology: Cell Actions and Reactions in Normal and Disease Niches Role:PI $10,000.00 Active Level:Federal

Grant: #2012-03973-01-00/ R01CA172220 Investigators:Kasper, Susan 01-01-2013 -12-31-2017 National Cancer Institute Estrogen Receptors in Human Prostate Stem-Progenitor Cells Role:Co-Investigator Active Type:Grant

Grant: #R01 DK060957 Investigators:Kasper, Susan 07-01-2009 -03-31-2011 National Inst of Diabetes and Digestive and Kidney Disease Development of Androgen Independent Prostate Cancer Role:PI $123,367.00 Closed Level:Federal

Grant: #W81XWH-08-L-0662 Investigators:Kasper, Susan 09-01-2008 -04-14-2013 Department of the Army Medical Research Acquisition Activity The Function of AR-Negative Cancer Stem Cells in Prostate Cancer Role:PI $575,625.00 Closed Level:Federal

Grant: #W81XWH-08-1-0370 Investigators:Kasper, Susan; Wang, Jiang 07-01-2008 -04-14-2013 Department of the Army Medical Research Acquisition Activity DJ-1 in the Development of Hormone Refractory Prostate Cancer Role:PI $568,378.00 Closed Level:Federal

Grant: #R01HD097597 Investigators:Burns, Katherine; Kasper, Susan; Niu, Liang 09-13-2019 -05-31-2024 National Institute of Child Health and Human Development The Role of the Matrisome in Endometriosis Development Role:Collaborator $439,549.00 Awarded Level:Federal

Grant: #CBET-2045234 Investigators:Banerjee, Rupak; Kasper, Susan 06-01-2021 -05-31-2024 National Science Foundation HIFU energized functionalized nanoparticles mediated enhanced thermal ablation of tumors Role:Collaborator 382179.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Vummidi Giridhar, Premkumar; Williams, Karin; VonHandorf, Andrew P; Deford, Paul L; Kasper, Susan (2019. ) Constant Degradation of the Androgen Receptor by MDM2 Conserves Prostate Cancer Stem Cell Integrity.Cancer research, , 79 (6 ) ,1124-1137 More Information

Langevin, Scott; Kuhnell, Damaris; Parry, Tess; Biesiada, Jacek; Huang, Shouxiong; Wise-Draper, Trisha; Casper, Keith; Zhang, Xiang; Medvedovic, Mario; Kasper, Susan (2017. ) Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cells in vitro reveals common secretion profiles and potential utility as salivary biomarkers.Oncotarget, , 8 (47 ) ,82459-82474 More Information

Williams K.;Giridhar P.;Kasper S. (04-19-2016. ) CD44 integrates signaling in stem cell microenvironments .Role of Cancer Stem Cells in Cancer Biology and Therapy, , 129-150

Varughese, Eunice A; Kasper, Susan; Anneken, Emily M; Yadav, Jagjit S (2015. ) SHP-2 Mediates Cryptosporidium parvum Infectivity in Human Intestinal Epithelial Cells.PloS one, , 10 (11 ) ,e0142219 More Information

Zhou J.;Giridhar P.;Kasper S.;Papautsky I. (07-01-2014. ) Modulation of rotation-induced lift force for cell filtration in a low aspect ratio microchannel.Biomicrofluidics, , 8 (4 ) , More Information

Zhou, Jian; Giridhar, Premkumar Vummidi; Kasper, Susan; Papautsky, Ian (2014. ) Modulation of rotation-induced lift force for cell filtration in a low aspect ratio microchannel.Biomicrofluidics, , 8 (4 ) ,044112 More Information

Zhou J.;Giridhar P.;Kasper S.;Papautsky I. (12-01-2013. ) Complete cell separation by modulating inertial force.2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013, , 1535-1538 More Information

Zhou J.;Kasper S.;Papautsky I. (11-01-2013. ) Enhanced size-dependent trapping of particles using microvortices.Microfluidics and Nanofluidics, , 15 (5 ) ,611-623 More Information

Zhou J.;Giridhar P.;Kasper S.;Papautsky I. (01-01-2013. ) Modulation of aspect ratio for complete separation in an inertial microfluidic channel.Lab on a Chip, , 13 (10 ) ,1919-1929 More Information

Zhou, Jian; Kasper, Susan; Papautsky, Ian (2013. ) Enhanced size-dependent trapping of particles using microvortices.Microfluidics and nanofluidics, , 15 (5 ) , More Information

Cai, Yuqi; Balli, David; Ustiyan, Vladimir; Fulford, Logan; Hiller, Andrea; Misetic, Vinko; Zhang, Yufang; Paluch, Andrew M; Waltz, Susan E; Kasper, Susan; Kalin, Tanya V (2013. ) Foxm1 expression in prostate epithelial cells is essential for prostate carcinogenesis.The Journal of biological chemistry, , 288 (31 ) ,22527-41 More Information

Zhou, Jian; Giridhar, Premkumar Vummidi; Kasper, Susan; Papautsky, Ian (2013. ) Modulation of aspect ratio for complete separation in an inertial microfluidic channel.Lab on a chip, , 13 (10 ) ,1919-29 More Information

Kendig, Eric L; Buesing, Dana R; Christie, Susie M; Cookman, Clifford J; Gear, Robin B; Hugo, Eric R; Kasper, Susan N; Kendziorski, Jessica A; Ungi, Kevin R; Williams, Karin; Belcher, Scott M (2012. ) Estrogen-like disruptive effects of dietary exposure to bisphenol A or 17α-ethinyl estradiol in CD1 mice.International journal of toxicology, , 31 (6 ) ,537-50 More Information

Williams, Karin; Ghosh, Ritwik; Giridhar, Premkumar Vummidi; Gu, Guangyu; Case, Thomas; Belcher, Scott M; Kasper, Susan (2012. ) Inhibition of stathmin1 accelerates the metastatic process.Cancer research, , 72 (20 ) ,5407-17 More Information

Zhou J.;Giridhar P.;Kasper S.;Papautsky I. (12-01-2011. ) Extraction and enrichment of rare cells in a simple inertial microfluidic device .15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, , 3 ,1906-1908

Nivedita N.;Giridhar P.;Kasper S.;Papautsky I. (12-01-2011. ) Sorting human prostate epithelial (HPET) cells in an inertial microfluidic device .15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, , 2 ,1230-1232

Liu, June; Pascal, Laura E; Isharwal, Sudhir; Metzger, Daniel; Ramos Garcia, Raquel; Pilch, Jan; Kasper, Susan; Williams, Karin; Basse, Per H; Nelson, Joel B; Chambon, Pierre; Wang, Zhou (2011. ) Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate.Molecular endocrinology (Baltimore, Md.), , 25 (11 ) ,1849-57 More Information

Zhang, JianFeng; Gao, Nan; DeGraff, David J; Yu, Xiuping; Sun, Qian; Case, Thomas C; Kasper, Susan; Matusik, Robert J (2010. ) Characterization of cis elements of the probasin promoter necessary for prostate-specific gene expression.The Prostate, , 70 (9 ) ,934-51 More Information

Kasper S. (12-01-2008. ) Exploring the origins of the normal prostate and prostate cancer stem cell (Stem Cell Reviews DOI: 1.Stem Cell Reviews, , 4 (4 ) ,329 More Information

Chaurand, Pierre; Rahman, Mohammad A; Hunt, Tamela; Mobley, James A; Gu, Guangyu; Latham, Joey C; Caprioli, Richard M; Kasper, Susan (2008. ) Monitoring mouse prostate development by profiling and imaging mass spectrometry.Molecular & cellular proteomics : MCP, , 7 (2 ) ,411-23 More Information

Kasper S. (10-01-2007. ) Editorial Comment.Journal of Urology, , 178 (4 ) ,1288 More Information

Ghosh, Ritwik; Gu, Guangyu; Tillman, Erin; Yuan, Jialing; Wang, Yongqing; Fazli, Ladan; Rennie, Paul S; Kasper, Susan (2007. ) Increased expression and differential phosphorylation of stathmin may promote prostate cancer progression.The Prostate, , 67 (10 ) ,1038-52 More Information

Gu, Guangyu; Yuan, Jialing; Wills, Marcia; Kasper, Susan (2007. ) Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo.Cancer research, , 67 (10 ) ,4807-15 More Information

Tillman, J Erin; Yuan, Jialing; Gu, Guangyu; Fazli, Ladan; Ghosh, Ritwik; Flynt, Alex S; Gleave, Martin; Rennie, Paul S; Kasper, Susan (2007. ) DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells.Cancer research, , 67 (10 ) ,4630-7 More Information

Gipp, Jerry; Gu, Guangyu; Crylen, Curtis; Kasper, Susan; Bushman, Wade (2007. ) Hedgehog pathway activity in the LADY prostate tumor model.Molecular cancer, , 6 ,19 More Information

Shao T.;Li H.;Kasper S.;Matusik R.;Ittmann M.;Cunningham G. (03-01-2006. ) Comparison of the growth-promoting effects of testosterone and 7-?-methyl-19-nor-testosterone (MENT).Prostate, , 66 (4 ) ,369-376 More Information

Wang, Yongqing; Kasper, Susan; Yuan, Jialing; Jin, Ren Jie; Zhang, Jianfeng; Ishii, Kenichiro; Wills, Marcia L; Hayward, Simon W; Matusik, Robert J (2006. ) Androgen-dependent prostate epithelial cell selection by targeting ARR(2)PBneo to the LPB-Tag model of prostate cancer.Laboratory investigation; a journal of technical methods and pathology, , 86 (10 ) ,1074-88 More Information

Pitkänen-Arsiola, Tiina; Tillman, J Erin; Gu, Guangyu; Yuan, Jialing; Roberts, Richard L; Wantroba, Marcus; Coetzee, Gerhard A; Cookson, Michael S; Kasper, Susan (2006. ) Androgen and anti-androgen treatment modulates androgen receptor activity and DJ-1 stability.The Prostate, , 66 (11 ) ,1177-93 More Information

Masumori N.;Tsuchiya K.;Tu W.;Lee C.;Kasper S.;Tsukamoto T.;Shappell S.;Matusik R. (01-01-2004. ) An allograft model of androgen independent prostatic neuroendocrine carcinoma derived from a large p.Journal of Urology, , 171 (1 ) ,439-442 More Information

Jin, Ren Jie; Wang, Yongqing; Masumori, Naoya; Ishii, Kenichiro; Tsukamoto, Taiji; Shappell, Scott B; Hayward, Simon W; Kasper, Susan; Matusik, Robert J (2004. ) NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice.Cancer research, , 64 (15 ) ,5489-95 More Information

Zhang, JianFeng; Gao, Nan; Kasper, Susan; Reid, Kimberly; Nelson, Colleen; Matusik, Robert J (2004. ) An androgen-dependent upstream enhancer is essential for high levels of probasin gene expression.Endocrinology, , 145 (1 ) ,134-48 More Information

Masumori, Naoya; Tsuchiya, Karen; Tu, William H; Lee, Charles; Kasper, Susan; Tsukamoto, Taiji; Shappell, Scott B; Matusik, Robert J (2004. ) An allograft model of androgen independent prostatic neuroendocrine carcinoma derived from a large probasin promoter-T antigen transgenic mouse line.The Journal of urology, , 171 (1 ) ,439-42 More Information

Tu, William H; Thomas, Tania Z; Masumori, Naoya; Bhowmick, Neil A; Gorska, Agnieszka E; Shyr, Yu; Kasper, Susan; Case, Tom; Roberts, Richard L; Shappell, Scott B; Moses, Harold L; Matusik, Robert J (2003. ) The loss of TGF-beta signaling promotes prostate cancer metastasis.Neoplasia (New York, N.Y.), , 5 (3 ) ,267-77 More Information

Zhang, Ye; Yu, Jiang; Unni, Emmanual; Shao, Tsang C; Nan, Bicheng; Snabboon, Thiti; Kasper, Susan; Andriani, Francesca; Denner, Larry; Marcelli, Marco (2002. ) Monogene and polygene therapy for the treatment of experimental prostate cancers by use of apoptotic genes bax and bad driven by the prostate-specific promoter ARR(2)PB.Human gene therapy, , 13 (17 ) ,2051-64 More Information

Andriani F.;Nan B.;Yu J.;Li X.;Weigel N.;McPhaul M.;Kasper S.;Kagawa S.;Fang B.;Matusik R.;Denner L.;Marcelli M. (09-05-2001. ) Use of the probasin promoter ARR2PB to express bax in androgen receptor-posit.Journal of the National Cancer Institute, , 93 (17 ) ,1314-1324 More Information

Chaurand, P; DaGue, B B; Ma, S; Kasper, S; Caprioli, R M (2001. ) Strain-based sequence variations and structure analysis of murine prostate specific spermine binding protein using mass spectrometry. Biochemistry, , 40 (32 ) ,9725-33

Masumori, N; Thomas, T Z; Chaurand, P; Case, T; Paul, M; Kasper, S; Caprioli, R M; Tsukamoto, T; Shappell, S B; Matusik, R J (2001. ) A probasin-large T antigen transgenic mouse line develops prostate adenocarcinoma and neuroendocrine carcinoma with metastatic potential. Cancer research, , 61 (5 ) ,2239-49

Lareyre, J J; Winfrey, V P; Kasper, S; Ong, D E; Matusik, R J; Olson, G E; Orgebin-Crist, M C (2001. ) Gene duplication gives rise to a new 17-kilodalton lipocalin that shows epididymal region-specific expression and testicular factor(s) regulation.Endocrinology, , 142 (3 ) ,1296-308 More Information

Lareyre, J J; Reid, K; Nelson, C; Kasper, S; Rennie, P S; Orgebin-Crist, M C; Matusik, R J (2000. ) Characterization of an androgen-specific response region within the 5' flanking region of the murine epididymal retinoic acid binding protein gene. Biology of reproduction, , 63 (6 ) ,1881-92

Zhang, J; Thomas, T Z; Kasper, S; Matusik, R J (2000. ) A small composite probasin promoter confers high levels of prostate-specific gene expression through regulation by androgens and glucocorticoids in vitro and in vivo.Endocrinology, , 141 (12 ) ,4698-710 More Information

Kasper, S; Matusik, R J (2000. ) Rat probasin: structure and function of an outlier lipocalin. Biochimica et biophysica acta, , 1482 (1-2 ) ,249-58

Shappell, S B; Boeglin, W E; Olson, S J; Kasper, S; Brash, A R (1999. ) 15-lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinoma.The American journal of pathology, , 155 (1 ) ,235-45 More Information

Kasper, S; Rennie, P S; Bruchovsky, N; Lin, L; Cheng, H; Snoek, R; Dahlman-Wright, K; Gustafsson, J A; Shiu, R P; Sheppard, P C; Matusik, R J (1999. ) Selective activation of the probasin androgen-responsive region by steroid hormones. Journal of molecular endocrinology, , 22 (3 ) ,313-25

Lareyre, J J; Thomas, T Z; Zheng, W L; Kasper, S; Ong, D E; Orgebin-Crist, M C; Matusik, R J (1999. ) A 5-kilobase pair promoter fragment of the murine epididymal retinoic acid-binding protein gene drives the tissue-specific, cell-specific, and androgen-regulated expression of a foreign gene in the epididymis of transgenic mice. The Journal of biological chemistry, , 274 (12 ) ,8282-90

Brash, A R; Jisaka, M; Boeglin, W E; Chang, M S; Keeney, D S; Nanney, L B; Kasper, S; Matusik, R J; Olson, S J; Shappell, S B (1999. ) Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues. Advances in experimental medicine and biology, , 469 ,83-9

Snoek R.;Bruchovsky N.;Kasper S.;Matusik R.;Gleave M.;Sato N.;Mawji N.;Rennie P. (09-01-1998. ) Differential transactivation by the androgen receptor in prostate cancer cells.Prostate, , 36 (4 ) ,256-263 More Information

Kasper S.;Sheppard P.;Yan Y.;Pettigrew N.;Borowsky A.;Prins G.;Dodd J.;Duckworth M.;Matusik R. (06-01-1998. ) Erratum: Development, progression, and androgen-dependence of prostate tumors in probasin-large T an .Laboratory Investigation, , 78 (6 ) ,

Bai G.E.;Kasper S.;Matusik R.J.;Rennie P.S.;Moshier J.A.;Krongrad A. (03-01-1998. ) Androgen regulation of the human ornithine decarboxylase promoter in prostate cancer cells .Journal of Andrology, , 19 (2 ) ,127-135

Lareyre, J J; Mattéi, M G; Kasper, S; Ong, D E; Matusik, R J; Orgebin-Crist, M C (1998. ) Genomic organization and chromosomal localization of the murine epididymal retinoic acid-binding protein (mE-RABP) gene.Molecular reproduction and development, , 50 (4 ) ,387-95 More Information

Lareyre, J J; Zheng, W L; Zhao, G Q; Kasper, S; Newcomer, M E; Matusik, R J; Ong, D E; Orgebin-Crist, M C (1998. ) Molecular cloning and hormonal regulation of a murine epididymal retinoic acid-binding protein messenger ribonucleic acid.Endocrinology, , 139 (6 ) ,2971-81 More Information

Kasper, S; Sheppard, P C; Yan, Y; Pettigrew, N; Borowsky, A D; Prins, G S; Dodd, J G; Duckworth, M L; Matusik, R J (1998. ) Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: a model for prostate cancer. Laboratory investigation; a journal of technical methods and pathology, , 78 (6 ) ,i-xv

Lareyre, J J; Mattéi, M G; Kasper, S; Newcomer, M E; Ong, D E; Matusik, R J; Orgebin-Crist, M C (1998. ) Structure and putative function of a murine epididymal retinoic acid-binding protein (mE-RABP). Journal of reproduction and fertility. Supplement, , 53 ,59-65

Metts, J C; Kotkin, L; Kasper, S; Shyr, Y; Adams, M C; Brock, J W (1997. ) Genital malformations and coexistent urinary tract or spinal anomalies in patients with imperforate anus. The Journal of urology, , 158 (3 Pt 2 ) ,1298-300

Yan, Y; Sheppard, P C; Kasper, S; Lin, L; Hoare, S; Kapoor, A; Dodd, J G; Duckworth, M L; Matusik, R J (1997. ) Large fragment of the probasin promoter targets high levels of transgene expression to the prostate of transgenic mice. The Prostate, , 32 (2 ) ,129-39

Snoek R.;Rennie P.;Kasper S.;Matusik R.;Bruchovsky N. (11-01-1996. ) Induction of cell-free, in vitro transcription by recombinant androgen receptor peptides.Journal of Steroid Biochemistry and Molecular Biology, , 59 (3-4 ) ,243-250 More Information

Kasper, S; Rennie, P S; Bruchovsky, N; Sheppard, P C; Cheng, H; Lin, L; Shiu, R P; Snoek, R; Matusik, R J (1994. ) Cooperative binding of androgen receptors to two DNA sequences is required for androgen induction of the probasin gene. The Journal of biological chemistry, , 269 (50 ) ,31763-9

Leite V.;Vrontakis M.;Kasper S.;Friesen H. (04-01-1993. ) Bromocriptine inhibits galanin gene expression in the rat pituitary gland.Molecular and Cellular Neuroscience, , 4 (5 ) ,418-423 More Information

Leite, V; Vrontakis, M E; Kasper, S; Friesen, H G (1993. ) Bromocriptine inhibits galanin gene expression in the rat pituitary gland.Molecular and cellular neurosciences, , 4 (5 ) ,418-23 More Information

Kasper, S; Popescu, R A; Torsello, A; Vrontakis, M E; Ikejiani, C; Friesen, H G (1992. ) Tissue-specific regulation of vasoactive intestinal peptide messenger ribonucleic acid levels by estrogen in the rat.Endocrinology, , 130 (4 ) ,1796-801 More Information

Fink, J S; Verhave, M; Kasper, S; Tsukada, T; Mandel, G; Goodman, R H (1988. ) The CGTCA sequence motif is essential for biological activity of the vasoactive intestinal peptide gene cAMP-regulated enhancer. Proceedings of the National Academy of Sciences of the United States of America, , 85 (18 ) ,6662-6

Rowe, J M; Kasper, S; Shiu, R P; Friesen, H G (1986. ) Purification and characterization of a human mammary tumor-derived growth factor. Cancer research, , 46 (3 ) ,1408-12

Kasper, S; Friesen, H G (1986. ) Human pituitary tissue secretes a potent growth factor for chondrocyte proliferation.The Journal of clinical endocrinology and metabolism, , 62 (1 ) ,70-6 More Information

Kasper, S; Worsley, I G; Rowe, J M; Shiu, R P; Friesen, H G (1982. ) Chondrocyte growth factor from the human pituitary gland. The Journal of biological chemistry, , 257 (9 ) ,5226-30

Additional Publications

Keywords

androgen receptor signaling, cancer stem cells, circulating tumor cells, inertial microfluidics, iMF, stathmin, Stmn1, DJ-1, prostate cancer, endocrine disruptor, endocrine disrupting chemicals, EDCs, flame retardants, FM 550

Contact Information

Academic - Department of Environmental Health
Kettering Laboratory
Phone: 513-558-2126
Susan.Kasper@uc.edu