Gary Kelm

Gary Robert Kelm

Adjunct Professor of Pharmaceutics and Cosmetic Science

Kowalewski Hall

267

Pharmacy Cosmetic Science Program - 0004

Kowalewski Hall 267
3225 Eden Ave.
Cincinnati, Ohio 45267

Professional Summary

Gary Kelm received his PhD in Biopharmaceutics and MS in Pharmaceutical Science from the University of Cincinnati, College of Pharmacy, and a BS in Chemical Engineering from Rose-Hulman Institute of Technology.  He retired from Procter & Gamble as a Research Fellow after 36 years in 2009.  At P&G, Dr. Kelm worked in formulation and drug/active delivery research and development on personal care, OTC drug, and pharmaceutical products.  Specific pharmaceutical areas included oral care, gastro-intestinal, analgesic and anti-inflammatory, and respiratory, OTC areas included respiratory, antiperspirants, analgesics (peroral and topical), and oral care, with skin care, hair care, and weight management among the personal care product areas.  Dr. Kelm has extensive experience in product formulation, drug/active delivery (enhanced bioavailability and targeted and controlled delivery), in vitro product evaluation, preclinical models, and clinical pharmacokinetics.  As an adjunct faculty of the College of Pharmacy, he has taught graduate courses in advanced biopharmaceutics and drug delivery, and his courses in the Cosmetic Science Program cover cosmetic and OTC drug formulation as well as OTC drug biopharmaceutics.   Dr. Kelm has 22 issued US patents and over forty published articles and abstracts.

Education

BSChE, Rose-Hulman Institute of Technology Terre Haute, IN, 1973 (Chemical Engineering)

MS, University of Cincinnati Cincinnati, OH, 1977 (Pharmaceutical Science with Emphasis in Cosmetic Science)

PhD, University of Cincinnati Cincinnati, OH, 1991 (Biopharmaceutics)

Research Support

Grant: #1U01FD005446-01 Investigators:Kelm, Gary; Li, Kevin 09-15-2015 -08-31-2017 Food and Drug Administration Development of a Dissolution Method for Long-acting Periodontal Drug Products Role:Collaborator $125,000.00 Active Level:Federal

Grant: #R15DE028701 Investigators:Kelm, Gary; Li, Kevin; McMahon, Jerome 08-15-2019 -08-14-2022 National Institute of Dental and Craniofacial Research Characterization of gingival drug delivery to improve local treatment Role:Collaborator $481,039.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Bissett, Donald L; Robinson, Larry R; Raleigh, Patricia S; Miyamoto, Kukizo; Hakozaki, Tomohiro; Li, Jim; Kelm, Gary R (2009. ) Reduction in the appearance of facial hyperpigmentation by topical N-undecyl-10-enoyl-L-phenylalanine and its combination with niacinamide.Journal of cosmetic dermatology, , 8 (4 ) ,260-6

Kemp, Christopher J; D'Alessio, David A; Scott, Robert O; Kelm, Gary R; Meller, Stephen T; Barrera, Jason G; Seeley, Randy J; Clegg, Deborah J; Benoit, Stephen C (2008. ) Voluntary consumption of ethyl oleate reduces food intake and body weight in rats.Physiology & behavior, , 93 (4-5 ) ,912-8

Bissett, Donald L; Robinson, Larry R; Raleigh, Patricia S; Miyamoto, Kukizo; Hakozaki, Tomohiro; Li, Jim; Kelm, Gary R (2007. ) Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine.Journal of cosmetic dermatology, , 6 (1 ) ,20-6

Cox, James E; Kelm, Gary R; Meller, Stephen T; Randich, Alan (2004. ) Suppression of food intake by GI fatty acid infusions: roles of celiac vagal afferents and cholecystokinin.Physiology & behavior, , 82 (1 ) ,27-33

Cox, James E; Kelm, Gary R; Meller, Stephen T; Spraggins, Daniel S; Randich, Alan (2004. ) Truncal and hepatic vagotomy reduce suppression of feeding by jejunal lipid infusions.Physiology & behavior, , 81 (1 ) ,29-36

Randich, Alan; Chandler, Paula C; Mebane, Hannah C; Turnbach, Meredith E; Meller, Stephen T; Kelm, Gary R; Cox, James E (2004. ) Jejunal administration of linoleic acid increases activity of neurons in the paraventricular nucleus of the hypothalamus.American journal of physiology. Regulatory, integrative and comparative physiology, , 286 (1 ) ,R166-73

Bookstaff, Robert C; PaiBir, Sheela; Bharaj, Satinder S; Kelm, Gary R; Kulick, Roy M; Balm, Timothy K; Murray, John V (2003. ) The safety of the use of ethyl oleate in food is supported by metabolism data in rats and clinical safety data in humans. Regulatory toxicology and pharmacology : RTP, , 37 (1 ) ,133-48

Randich, Alan; Spraggins, D Seth; Meller, Stephen T; Kelm, Gary R; Cox, James E (2002. ) Responses of hepatic and celiac vagal afferents to intraportal mercaptoacetate in rats fed a high-fat or low-fat diet. Neuroreport, , 13 (5 ) ,675-9

Randich, A; Spraggins, D S; Cox, J E; Meller, S T; Kelm, G R (2001. ) Jejunal or portal vein infusions of lipids increase hepatic vagal afferent activity. Neuroreport, , 12 (14 ) ,3101-5

Tegeder, I; Lötsch, J; Kinzig-Schippers, M; Sörgel, F; Kelm, G R; Meller, S T; Geisslinger, G (2001. ) Comparison of tissue concentrations after intramuscular and topical administration of ketoprofen. Pharmaceutical research, , 18 (7 ) ,980-6

Cox, J E; Tyler, W J; Randich, A; Kelm, G R; Meller, S T (2001. ) Celiac vagotomy reduces suppression of feeding by jejunal fatty acid infusions. Neuroreport, , 12 (6 ) ,1093-6

Cox, J E; Tyler, W J; Randich, A; Kelm, G R; Bharaj, S S; Jandacek, R J; Meller, S T (2000. ) Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions. American journal of physiology. Regulatory, integrative and comparative physiology, , 278 (3 ) ,R604-10

Randich, A; Tyler, W J; Cox, J E; Meller, S T; Kelm, G R; Bharaj, S S (2000. ) Responses of celiac and cervical vagal afferents to infusions of lipids in the jejunum or ileum of the rat. American journal of physiology. Regulatory, integrative and comparative physiology, , 278 (1 ) ,R34-43

Abdul Manap, R; Wright, C E; Gregory, A; Rostami-Hodjegan, A; Meller, S T; Kelm, G R; Lennard, M S; Tucker, G T; Morice, A H (1999. ) The antitussive effect of dextromethorphan in relation to CYP2D6 activity. British journal of clinical pharmacology, , 48 (3 ) ,382-7

Tegeder, I; Muth-Selbach, U; Lötsch, J; Rüsing, G; Oelkers, R; Brune, K; Meller, S; Kelm, G R; Sörgel, F; Geisslinger, G (1999. ) Application of microdialysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration.Clinical pharmacology and therapeutics, , 65 (4 ) ,357-68

Kelm, G R; Buchanan, W; Meredith, M P; Offenbacher, S; Mankodi, S M; Dobrozsi, D J; Bapat, N V; Collins, J G; Wehmeyer, K R; Eichhold, T H; Doyle, M J (1996. ) Evaluation of ketorolac concentrations in plasma and gingival crevicular fluid following topical treatment with oral rinses and dentifrices.Journal of pharmaceutical sciences, , 85 (8 ) ,842-7

Tulich, L J; Randall, J L; Kelm, G R; Wehmeyer, K R (1996. ) Determination of two mebeverine metabolites, mebeverine alcohol and desmethylmebeverine alcohol, in human plasma by a dual stable isotope-based gas chromatographic-mass spectrometric method. Journal of chromatography. B, Biomedical applications, , 682 (2 ) ,273-81

Ares, J J; Outt, P E; Randall, J L; Murray, P D; Weisshaar, P S; O'Brien, L M; Ems, B L; Kakodkar, S V; Kelm, G R; Kershaw, W C (1995. ) Synthesis and biological evaluation of substituted flavones as gastroprotective agents. Journal of medicinal chemistry, , 38 (25 ) ,4937-43

Cruze, C A; Kelm, G R; Meredith, M P (1995. ) Interspecies scaling of tebufelone pharmacokinetic data and application to preclinical toxicology. Pharmaceutical research, , 12 (6 ) ,895-901

Dobson, R L; Kelm, G R; Neal, D M (1994. ) Automated gas chromatography/tandem mass spectrometry assay for tebufelone and a 13C,(18)O-labeled analog in plasma: applicabilityto absolute bioavailability determination.Biological mass spectrometry, , 23 (2 ) ,75-81

Doyle, M J; Eichhold, T H; Loomans, M E; Farmer, R W; Kelm, G R (1993. ) Comparison of tebufelone distribution in rat blood plasma and inflamed and noninflamed tissues following peroral and intravenous administration. Journal of pharmaceutical sciences, , 82 (8 ) ,847-50

Sietsema, W K; Kelm, G R; Deibel, R M; Doyle, M J; Loomans, M E; Smyth, R E; Kinnett, G O; Eichhold, T H; Farmer, R W (1993. ) Absorption, bioavailability, and pharmacokinetics of tebufelone in the rat. Journal of pharmaceutical sciences, , 82 (6 ) ,610-2

Honors and Awards

2018 -2018 Outstanding Adjunct Faculty Selection as University of Cincinnati's outstanding adjunct faculty (annual appointment) for 2017-2018 academic year. Status:Recipient Level:University

Contact Information

Academic - Kowalewski Hall 267
3225 Eden Ave.
Cincinnati  Ohio, 45267
Phone: 513-558-5828
kelmg@ucmail.uc.edu