Marat Khodoun

Marat V. Khodoun , PhD

Research Associate Professor

Health Professions Building
3255 Eden Avenue
Suite 350
Cincinnati, Ohio 45267
Phone 513-558-4701
Fax 513-558-3799
Email marat.khodoun@uc.edu

Education

Bachelor's Degree: Tomsk State University 1984 (Biology)

Master's Degree: Moscow Academy of Veterinary Medicine Moscow, Russia, 1990 (Biochemistry)

Doctoral Degree: National Research Institute for Agricultural Biotechnology 1994 (Molecular Biology)

Research Fellowship: Lab of Genes Engineering All-Russia Research Institute for Agricultural Biotechnology 1997

Research Fellowship : Cincinnati Children's Hospital Research Foundation 2003 (Developmental Biology )

Research and Practice Interests

Study of allergic, anaphylactic, and inflammatory reactions such as atopy, asthma, food allergy, and intestinal inflammation.

Positions and Work Experience

2007 -To Present Research Instructor, Division of Immunology, Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

2003 -2007 Research Associate, Division of Immunology, Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

1997 -2001 Staff Scientist, Lab of Genes Engineering, All-Russia Research Institute for Agricultural Biotechnology, Moscow, Russia

Research Support

Grant: #R21 AI079947 NIH Identification of Proteins Responsible for Peanut Allergenecity

Grant: #5P01HL076383-040002 NIH Unique Effects of IL-13 in Asthma: Mechanistic Analysis

Grant: #R01 HL 097360 Investigators:F Finkelman 09-01-2009 -08-31-2011 NIH/NHLBI Effects of IL-4 and IL-13 on Pulmonary Smooth Muscle in Allergic Airway Disease Role:Co-I $476,818

Grant: #R21 AI079947 Investigators:Finkelman, Fred; Khodoun, Marat 06-18-2008 -05-31-2010 National Institute of Allergy and Infectious Diseases Identification Of Proteins Responsible For Peanut Allergenicity Role:Collaborator $429,000.00 Closed Level:Federal

Grant: #VA IPA Marat Khodoun Investigators:Khodoun, Marat 05-01-2012 -12-31-2012 Department of Veterans Affairs Intergovernmental Personnel Act Agreement - Marat Khodoun Role:PI $44,572.00 Closed Level:Federal

Grant: #R21AI103816 Investigators:Denson, Lee; Finkelman, Fred; Khodoun, Marat 07-01-2012 -06-30-2014 National Institute of Allergy and Infectious Diseases Human IgG-mediated Anaphylaxis Role:Collaborator $425,647.00 Active Level:Federal

Grant: #CFBRE 00100 sub W81XWH-13-1-0497 Investigators:Finkelman, Fred; Khodoun, Marat 09-30-2013 -09-29-2016 Department of the Army Research, Development and Engineering Command Induction of food allergy by inhaled allergen Role:PI $104,381.00 Active Level:Federal

Grant: #Research Agreement Investigators:Finkelman, Fred; Khodoun, Marat; Morris, Suzanne 06-01-2014 -05-31-2017 Food Allergy Research & Education, Inc. Rapid suppression of food allergy with anti-Fc epsilon RI alpha antibody Role:Collaborator $734,986.00 Awarded Level:Private Non-Profit

Grant: #R01AI130103 Investigators:Finkelman, Fred; Khodoun, Marat 01-25-2017 -12-31-2021 National Institute of Allergy and Infectious Diseases Wimpy antibody isotypes protect against antibody-mediated disease Role:Collaborator $371,842.00 Active Level:Federal

Grant: #PTRF# 2017-09 Investigators:Conforti, Laura; Khodoun, Marat 02-01-2018 -01-31-2019 Dialysis Clinic, Inc. Targeted nanoparticle-based therapy in SLE Role:Collaborator $60,000.00 Active Level:Private Non-Profit

Grant: #R01AI145991 Investigators:Finkelman, Fred; Khodoun, Marat; Morris, Suzanne 07-05-2018 -06-30-2024 National Institute of Allergy and Infectious Diseases Rapid, safe suppression of IgE-mediated disease with monovalent anti-FceRIa mAb Role:Collaborator $383,995.00 Awarded Level:Federal

Grant: #R01 AI145991 Investigators:Finkelman, Fred; Khodoun, Marat; Morris, Suzanne 07-05-2019 -06-30-2024 National Institute of Allergy and Infectious Diseases Rapid, safe suppression of IgE-mediated disease with monovalent anti-FceRIa mAb Role:Collaborator $383,995.00 Awarded Level:Federal

Grant: #CCHMC 309704 / R01AI148226 Investigators:Khodoun, Marat 09-20-2019 -08-31-2024 National Institute of Allergy and Infectious Diseases Genomics of Inflammatory Bowel Disease Role:PI $21,971.44 Active Level:Federal

Grant: #R01 AI113162 Investigators:Finkelman, Fred; Khodoun, Marat; Morris, Suzanne 07-15-2014 -06-30-2020 National Institute of Allergy and Infectious Diseases Suppression of IgE-Mediated Disease by Polyclonal Rapid Desensitization Role:Collaborator 1585669.00 Active Level:Federal

Publications

Peer Reviewed Publications

Khodoun, Marat V; Strait, Richard; Armstrong, Laura; Yanase, Noriko; Finkelman, Fred D (2011. ) Identification of markers that distinguish IgE- from IgG-mediated anaphylaxis.Proceedings of the National Academy of Sciences of the United States of America, , More Information

Morris, Suzanne C; Heidorn, Stephanie M; Herbert, De'Broski R; Perkins, Charles; Hildeman, David A; Khodoun, Marat V; Finkelman, Fred D (2009. ) Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation. Journal of immunology (Baltimore, Md. : 1950), , 182 (3 ) ,1429-38

Khodoun, Marat V; Orekhova, Tatyana; Potter, Crystal; Morris, Suzanne; Finkelman, Fred D (2004. ) Basophils initiate IL-4 production during a memory T-dependent response.The Journal of experimental medicine, , 200 (7 ) ,857-70 More Information

Khodoun, Marat V; Morris, Suzanne C; Angerman, Elizabeth; Potter, Crystal; Schuman, Richard; Wunderlich, Mark; Maciag, Joseph J; Sullivan Locker, Kathryn C; Mulloy, James C; Herr, Andrew B; Finkelman, Fred D (2020. ) Rapid desensitization of humanized mice with anti-human Fc?RI? monoclonal antibodies.The Journal of allergy and clinical immunology, , 145 (3 ) ,907-921.e3 More Information

Clay, Corey D; Strait, Richard T; Mahler, Ashley; Khodoun, Marat V; Finkelman, Fred D (2018. ) Anti-Fc?RIIB mAb suppresses murine IgG-dependent anaphylaxis by Fc domain targeting of Fc?RIII.The Journal of allergy and clinical immunology, , 141 (4 ) ,1373-1381.e5 More Information

Khodoun, Marat V; Tomar, Sunil; Tocker, Joel E; Wang, Yui Hsi; Finkelman, Fred D (2018. ) Prevention of food allergy development and suppression of established food allergy by neutralization of thymic stromal lymphopoietin, IL-25, and IL-33.The Journal of allergy and clinical immunology, , 141 (1 ) ,171-179.e1 More Information

Minar, Phillip; Jackson, Kimberly; Tsai, Yi-Ting; Rosen, Michael J; Northcutt, Michael; Khodoun, Marat; Finkelman, Fred D; Denson, Lee A (2016. ) A Low Neutrophil CD64 Index Is Associated with Sustained Remission During Infliximab Maintenance Therapy.Inflammatory bowel diseases, , 22 (11 ) ,2641-2647 More Information

Finkelman, Fred D; Khodoun, Marat V; Strait, Richard (2016. ) Human IgE-independent systemic anaphylaxis.The Journal of allergy and clinical immunology, , 137 (6 ) ,1674-1680 More Information

Gieras, Anna; Linhart, Birgit; Roux, Kenneth H; Dutta, Moumita; Khodoun, Marat; Zafred, Domen; Cabauatan, Clarissa R; Lupinek, Christian; Weber, Milena; Focke-Tejkl, Margarete; Keller, Walter; Finkelman, Fred D; Valenta, Rudolf (2016. ) IgE epitope proximity determines immune complex shape and effector cell activation capacity.The Journal of allergy and clinical immunology, , 137 (5 ) ,1557-65 More Information

McAlees, Jaclyn W; Lajoie, Stephane; Dienger, Krista; Sproles, Alyssa A; Richgels, Phoebe K; Yang, Yanfen; Khodoun, Marat; Azuma, Miyuki; Yagita, Hideo; Fulkerson, Patricia C; Wills-Karp, Marsha; Lewkowich, Ian P (2015. ) Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma.European journal of immunology, , 45 (4 ) ,1019-29 More Information

Strait, Richard T; Posgai, Monica T; Mahler, Ashley; Barasa, Nathaniel; Jacob, Chaim O; Köhl, Jörg; Ehlers, Marc; Stringer, Keith; Shanmukhappa, Shiva Kumar; Witte, David; Hossain, Md Monir; Khodoun, Marat; Herr, Andrew B; Finkelman, Fred D (2015. ) IgG1 protects against renal disease in a mouse model of cryoglobulinaemia.Nature, , 517 (7535 ) ,501-4 More Information

Kumar, Sudhir; Khodoun, Marat; Kettleson, Eric M; McKnight, Christopher; Reponen, Tiina; Grinshpun, Sergey A; Adhikari, Atin (2014. ) Glyphosate-rich air samples induce IL-33, TSLP and generate IL-13 dependent airway inflammation.Toxicology, , 325 ,42-51 More Information

Khodoun, Marat V; Kucuk, Zeynep Yesim; Strait, Richard T; Krishnamurthy, Durga; Janek, Kevin; Clay, Corey D; Morris, Suzanne C; Finkelman, Fred D (2013. ) Rapid desensitization of mice with anti-Fc?RIIb/Fc?RIII mAb safely prevents IgG-mediated anaphylaxis.The Journal of allergy and clinical immunology, , 132 (6 ) ,1375-87 More Information

Khodoun, Marat V; Kucuk, Zeynep Yesim; Strait, Richard T; Krishnamurthy, Durga; Janek, Kevin; Lewkowich, Ian; Morris, Suzanne C; Finkelman, Fred D (2013. ) Rapid polyclonal desensitization with antibodies to IgE and Fc?RI?.The Journal of allergy and clinical immunology, , 131 (6 ) ,1555-64 More Information

Kucuk, Zeynep Yesim; Strait, Richard; Khodoun, Marat V; Mahler, Ashley; Hogan, Simon; Finkelman, Fred D (2012. ) Induction and suppression of allergic diarrhea and systemic anaphylaxis in a murine model of food allergy.The Journal of allergy and clinical immunology, , 129 (5 ) ,1343-8 More Information

Strait, Richard T; Hicks, Wyenona; Barasa, Nathaniel; Mahler, Ashley; Khodoun, Marat; Köhl, Jörg; Stringer, Keith; Witte, David; Van Rooijen, Nico; Susskind, Brian M; Finkelman, Fred D (2011. ) MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice.The Journal of experimental medicine, , 208 (12 ) ,2525-44 More Information

Strait, Richard T; Mahler, Ashley; Hogan, Simon; Khodoun, Marat; Shibuya, Akira; Finkelman, Fred D (2011. ) Ingested allergens must be absorbed systemically to induce systemic anaphylaxis.The Journal of allergy and clinical immunology, , 127 (4 ) ,982-9.e1 More Information

Herbert, De'Broski R; Yang, Jun-Qi; Hogan, Simon P; Groschwitz, Kathryn; Khodoun, Marat; Munitz, Ariel; Orekov, Tatyana; Perkins, Charles; Wang, Quan; Brombacher, Frank; Urban, Joseph F; Rothenberg, Marc E; Finkelman, Fred D (2009. ) Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection.The Journal of experimental medicine, , 206 (13 ) ,2947-57 More Information

Madan, Rajat; Demircik, Filiz; Surianarayanan, Sangeetha; Allen, Jessica L; Divanovic, Senad; Trompette, Aurelien; Yogev, Nir; Gu, Yuanyuan; Khodoun, Marat; Hildeman, David; Boespflug, Nicholas; Fogolin, Mariela B; Gröbe, Lothar; Greweling, Marina; Finkelman, Fred D; Cardin, Rhonda; Mohrs, Markus; Müller, Werner; Waisman, Ari; Roers, Axel; Karp, Christopher L (2009. ) Nonredundant roles for B cell-derived IL-10 in immune counter-regulation.Journal of immunology (Baltimore, Md. : 1950), , 183 (4 ) ,2312-20 More Information

Khodoun, Marat; Strait, Richard; Orekov, Tatyana; Hogan, Simon; Karasuyama, Hajime; Herbert, De'broski R; Köhl, Jörg; Finkelman, Fred D (2009. ) Peanuts can contribute to anaphylactic shock by activating complement.The Journal of allergy and clinical immunology, , 123 (2 ) ,342-51 More Information

Khodoun, Marat; Lewis, Christina C; Lewis, Christina; Yang, Jun-Qi; Orekov, Tatyana; Potter, Crystal; Wynn, Thomas; Mentink-Kane, Margaret; Hershey, Gurjit K Khurana; Wills-Karp, Marsha; Finkelman, Fred D (2007. ) Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responses.Journal of immunology (Baltimore, Md. : 1950), , 179 (10 ) ,6429-38 More Information

Belenkaya, Tatyana Y; Han, Chun; Yan, Dong; Opoka, Robert J; Khodoun, Marat; Liu, Hongzhu; Lin, Xinhua (2004. ) Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans.Cell, , 119 (2 ) ,231-44 More Information

Han, Chun; Belenkaya, Tatyana Y; Khodoun, Marat; Tauchi, Miyuki; Lin, Xinda; Lin, Xinhua (2004. ) Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation.Development (Cambridge, England), , 131 (7 ) ,1563-75 More Information

Strait R.;Posgai M.;Mahler A.;Barasa N.;Jacob C.;Köhl J.;Ehlers M.;Stringer K.;Shanmukhappa S.;Witte D.;Hossain M.;Khodoun M.;Herr A.;Finkelman F. (10-29-2015. ) Erratum: IgG1 protects against renal disease in a mouse model of cryoglobulinaemia (Nature (2015) 51.Nature, , 526 (7575 ) ,728 More Information

Khodoun M.V.;Kucuk Z.Y.;Strait R.T.;Krishnamurthy D.;Janek K.;Clay C.D.;Morris S.C.;Finkelman F.D. (01-01-2013. ) Rapid desensitization of mice with anti-Fc?RIIb/Fc?RIII mAb safely prevents IgG-mediated anaphylaxis.Journal of Allergy and Clinical Immunology, , 132 (6 ) ,1375-1387 More Information

Khodoun M.V.;Kucuk Z.Y.;Strait R.T.;Krishnamurthy D.;Janek K.;Lewkowich I.;Morris S.C.;Finkelman F.D. (01-01-2013. ) Rapid polyclonal desensitization with antibodies to IgE and Fc?RI?.Journal of Allergy and Clinical Immunology, , 131 (6 ) , More Information

Strait R.;Mahler A.;Hogan S.;Khodoun M.;Shibuya A.;Finkelman F. (01-01-2011. ) Ingested allergens must be absorbed systemically to induce systemic anaphylaxis.Journal of Allergy and Clinical Immunology, , 127 (4 ) , More Information

Khodoun M.;Lewis C.;Yang J.;Orekov T.;Potter C.;Wynn T.;Mentink-Kane M.;Khurana Hershey G.;Wills-Karp M.;Finkelman F. (01-01-2008. ) Differences in expression, affinity, and function of soluble (s)IL-4R? and sIL-13R?2 suggest opposit .Journal of Immunology, , 180 (1 ) ,664

Munitz A.;Bachelet I.;Eliashar R.;Khodoun M.;Finkelman F.;Rothenberg M.;Levi-Schaffer F. (07-01-2006. ) CD48 is an allergen and IL-3-induced activation molecule on eosinophils.Journal of Immunology, , 177 (1 ) ,77-83 More Information

Shilov I.;Tashlitsky V.;Khodoun M.;Vasil'ev S.;Alekseev Y.;Kuzubov A.;Kubareva E.;Karyagina A. (06-01-1998. ) DNA-methyltransferase Ssoll interaction with own promoter region binding site.Nucleic Acids Research, , 26 (11 ) ,2659-2664 More Information

Karyagina A.;Shilov I.;Tashlitskii V.;Khodoun M.;Vasil'ev S.;Lau P.;Nikolskaya I. (08-02-1997. ) Specific binding of SsoII DNA methyltransferase to its promoter region provides the regulation of Ss.Nucleic Acids Research, , 25 (11 ) ,2114-2120 More Information

Honors and Awards

2000 Gold medal of All-Russia State Exhibition for the Project "Development of biochip for nucleic acid analysis"

1990 Award for Graduation of Department of Biology and Veterinary Medicine Moscow Academy of Veterinary Medicine cum laude

Contact Information

Academic - Health Professions Building
3255 Eden Avenue
Cincinnati  Ohio, 45267
Phone: 513-558-4701
Fax: 513-558-3799
marat.khodoun@uc.edu