KyoungHyun Kim

KyoungHyun Kim

Assistant Professor, Department of Environmental Health, UC College of Medicine

Kettering Lab Complex

COM EH EGMT Kim Lab - 0056

University of Cincinnati Department of Environmental Health
Kettering Hall

Research Support

Grant: #R25079 Investigators:Kim, KyoungHyun 04-01-2019 -03-31-2020 UC's URC Faculty Research Cost Support Awards Program A Preventive Role of Nuclear Receptor NR2E3 in Liver Cancer Role:PI $7,500.00 Active Level:Internal UC


Peer Reviewed Publications

Yang, Won Seok; Chadalapaka, Gayathri; Cho, Sung-Gook; Lee, Syng-Ook; Jin, Un-Ho; Jutooru, Indira; Choi, Kwangmin; Leung, Yuet-Kin; Ho, Shuk-Mei; Safe, Stephen; Kim, Kyounghyun (2014. )The Transcriptional Repressor ZBTB4 Regulates EZH2 Through a MicroRNA-ZBTB4-Specificity Protein Signaling Axis.Neoplasia (New York, N.Y.), ,16 (12 ),1059-69

Zhang, Zichao; Kim, KyoungHyun; Li, Xiao; Moreno, Myriam; Sharp, Thad; Goodheart, Michael J; Safe, Stephen; Dupuy, Adam J; Amendt, Brad A (2014. )MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression.Molecular cancer therapeutics, ,13 (7 ),1942-51

Jutooru, Indira; Guthrie, Aaron S; Chadalapaka, Gayathri; Pathi, Satya; Kim, KyoungHyun; Burghardt, Robert; Jin, Un-Ho; Safe, Stephen (2014. )Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents.Molecular and cellular biology, ,34 (13 ),2382-95

Chadalapaka, Gayathri; Jutooru, Indira; Sreevalsan, Sandeep; Pathi, Satya; Kim, Kyounghyun; Chen, Candy; Crose, Lisa; Linardic, Corinne; Safe, Stephen (2013. )Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors.International journal of cancer. Journal international du cancer, ,132 (4 ),795-806

Gandhy, Shruti U; Kim, Kyounghyun; Larsen, Lesley; Rosengren, Rhonda J; Safe, Stephen (2012. )Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs.BMC cancer, ,12 ,564

Park, Yun-Yong; Jung, Sung Yun; Jennings, Nicholas B; Rodriguez-Aguayo, Cristian; Peng, Guang; Lee, Se-Ran; Kim, Sang Bae; Kim, Kyounghyun; Leem, Sun-Hee; Lin, Shiaw-Yih; Lopez-Berestein, Gabriel; Sood, Anil K; Lee, Ju-Seog (2012. )FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair.Carcinogenesis, ,33 (10 ),1843-53

Kim, Kyounghyun; Chadalapaka, Gayathri; Pathi, Satya S; Jin, Un-Ho; Lee, Ju-Seog; Park, Yun-Yong; Cho, Sung-Gook; Chintharlapalli, Sudhakar; Safe, Stephen (2012. )Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters.Molecular cancer therapeutics, ,11 (9 ),1852-62

Liu, Xinyi; Jutooru, Indira; Lei, Ping; Kim, KyoungHyun; Lee, Syng-Ook; Brents, Lisa K; Prather, Paul L; Safe, Stephen (2012. )Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.Molecular cancer therapeutics, ,11 (7 ),1421-31

Park, Yun-Yong; Kim, Kyounghyun; Kim, Sang-Bae; Hennessy, Bryan T; Kim, Soo Mi; Park, Eun Sung; Lim, Jae Yun; Li, Jane; Lu, Yiling; Gonzalez-Angulo, Ana Maria; Jeong, Woojin; Mills, Gordon B; Safe, Stephen; Lee, Ju-Seog (2012. )Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer.EMBO molecular medicine, ,4 (1 ),52-67

Zhang, Shu; Kim, KyoungHyun; Jin, Un Ho; Pfent, Catherine; Cao, Huojun; Amendt, Brad; Liu, Xinyi; Wilson-Robles, Heather; Safe, Stephen (2012. )Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells.Molecular cancer therapeutics, ,11 (1 ),108-18

Yoon, Kyungsil; Lee, Syng-Ook; Cho, Sung-Dae; Kim, Kyounghyun; Khan, Shaheen; Safe, Stephen (2011. )Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors.Carcinogenesis, ,32 (6 ),836-42

Kim, Kyounghyun; Burghardt, Robert; Barhoumi, Rola; Lee, Syng-Ook; Liu, Xinyi; Safe, Stephen (2011. )MDM2 regulates estrogen receptor ? and estrogen responsiveness in breast cancer cells.Journal of molecular endocrinology, ,46 (2 ),67-79

Claerhout, Sofie; Lim, Jae Yun; Choi, Woonyoung; Park, Yun-Yong; Kim, Kyounghyun; Kim, Sang-Bae; Lee, Ju-Seog; Mills, Gordon B; Cho, Jae Yong (2011. )Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer.PloS one, ,6 (9 ),e24662

Lee, Syng-Ook; Abdelrahim, Maen; Yoon, Kyungsil; Chintharlapalli, Sudhakar; Papineni, Sabitha; Kim, Kyounghyun; Wang, Huamin; Safe, Stephen (2010. )Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth.Cancer research, ,70 (17 ),6824-36

Li, Xiangrong; Mertens-Talcott, Susanne U; Zhang, Shu; Kim, Kyounghyun; Ball, Judith; Safe, Stephen (2010. )MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells.Endocrinology, ,151 (6 ),2462-73

Wu, Fei; Xu, Rui; Kim, Kyounghyun; Martin, James; Safe, Stephen (2008. )In vivo profiling of estrogen receptor/specificity protein-dependent transactivation.Endocrinology, ,149 (11 ),5696-705

Safe, Stephen; Kim, Kyounghyun; Kim, Kyoungkim (2008. )Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways.Journal of molecular endocrinology, ,41 (5 ),263-75

Naugler, Willscott E; Sakurai, Toshiharu; Kim, Sunhwa; Maeda, Shin; Kim, Kyounghyun; Elsharkawy, Ahmed M; Karin, Michael (2007. )Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production.Science (New York, N.Y.), ,317 (5834 ),121-4

Khan, Shaheen; Barhoumi, Rola; Burghardt, Robert; Liu, Shengxi; Kim, Kyounghyun; Safe, Stephen (2006. )Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.Molecular endocrinology (Baltimore, Md.), ,20 (9 ),2199-214

Abdelrahim, Maen; Ariazi, Eric; Kim, Kyounghyun; Khan, Shaheen; Barhoumi, Rola; Burghardt, Robert; Liu, Shengxi; Hill, Denise; Finnell, Richard; Wlodarczyk, Bogdan; Jordan, V Craig; Safe, Stephen (2006. )3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha.Cancer research, ,66 (4 ),2459-67

Kim, Kyounghyun; Barhoumi, Rola; Burghardt, Robert; Safe, Stephen (2005. )Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer.Molecular endocrinology (Baltimore, Md.), ,19 (4 ),843-54

Lee, Jeongeun Eun; Kim, Kyounghyun; Sacchettini, James C; Smith, Clare V; Safe, Stephen (2005. )DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs.The Journal of biological chemistry, ,280 (10 ),8819-30

Safe, Stephen; Kim, Kyounghyun (2004. )Nuclear receptor-mediated transactivation through interaction with Sp proteins.Progress in nucleic acid research and molecular biology, ,77 ,1-36

Kim, Kyounghyun; Thu, Nguyen; Saville, Brad; Safe, Stephen (2003. )Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells.Molecular endocrinology (Baltimore, Md.), ,17 (5 ),804-17

Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, Kim S, Safe S. (2013. )HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene, ,32 (13 ),1616

Yang GY, Liao J, Kim K, Yurkow EJ, Yang CS (1998. )Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. Carcinogenesis, ,19 (4 ),611

Porter W, Wang F, Duan R, Qin C, Castro-Rivera E, Kim K, Safe S. (2001. )Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists. J Mol Endocrinol., ,26 (1 ),31

Safe S, Kim K. (2004. )Nuclear receptor-mediated transactivation through interaction with Sp proteins. Prog Nucleic Acid Res Mol Biol, ,77 ,1

Gandhy, Shruti U; Imanirad, Parisa; Jin, Un-Ho; Nair, Vijayalekshmi; Hedrick, Eric; Cheng, Yating; Corton, J Christopher; Kim, KyoungHyun; Safe, Stephen (2015. )Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC. Oncotarget, ,6 (28 ),26359-72

Khanal, Tilak; Kim, Dasom; Johnson, Abby; Choubey, Divaker; Kim, Kyounghyun (2015. )Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter.Toxicology letters, ,237 (3 ),228-36

Ko, Seong-Gyu; Yin, Chang Shik; Du, Bing; Kim, KyoungHyun (2014. )Herbal medicines for inflammatory diseases.Mediators of inflammation, ,2014 ,982635

Khanal, Tilak; Choi, Kwangmin; Leung, Yuet-Kin; Wang, Jiang; Kim, Dasom; Janakiram, Vinothini; Cho, Sung-Gook; Puga, Alvaro; Ho, Shuk-Mei; Kim, Kyounghyun (2017. )Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer.Scientific reports, ,7 (1 ),10662

Contact Information

Academic - University of Cincinnati Department of Environmental Health
Kettering Hall
Phone: 513-558-4851