KyoungHyun Kim

KyoungHyun Kim

Assistant Professor

Kettering Lab Complex

COM EH EGMT Kim Lab - 0056

University of Cincinnati Department of Environmental Health
Kettering Hall

Research Support

Grant: #R25079 Investigators:Kim, KyoungHyun 04-01-2019 -03-31-2020 UC's URC Faculty Research Cost Support Awards Program A Preventive Role of Nuclear Receptor NR2E3 in Liver Cancer Role:PI $7,500.00 Active Level:Internal UC


Peer Reviewed Publications

Yang, Won Seok; Chadalapaka, Gayathri; Cho, Sung-Gook; Lee, Syng-Ook; Jin, Un-Ho; Jutooru, Indira; Choi, Kwangmin; Leung, Yuet-Kin; Ho, Shuk-Mei; Safe, Stephen; Kim, Kyounghyun (2014. ) The Transcriptional Repressor ZBTB4 Regulates EZH2 Through a MicroRNA-ZBTB4-Specificity Protein Signaling Axis.Neoplasia (New York, N.Y.), , 16 (12 ) ,1059-69

Zhang, Zichao; Kim, KyoungHyun; Li, Xiao; Moreno, Myriam; Sharp, Thad; Goodheart, Michael J; Safe, Stephen; Dupuy, Adam J; Amendt, Brad A (2014. ) MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression.Molecular cancer therapeutics, , 13 (7 ) ,1942-51

Jutooru, Indira; Guthrie, Aaron S; Chadalapaka, Gayathri; Pathi, Satya; Kim, KyoungHyun; Burghardt, Robert; Jin, Un-Ho; Safe, Stephen (2014. ) Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents.Molecular and cellular biology, , 34 (13 ) ,2382-95

Chadalapaka, Gayathri; Jutooru, Indira; Sreevalsan, Sandeep; Pathi, Satya; Kim, Kyounghyun; Chen, Candy; Crose, Lisa; Linardic, Corinne; Safe, Stephen (2013. ) Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors.International journal of cancer. Journal international du cancer, , 132 (4 ) ,795-806

Gandhy, Shruti U; Kim, Kyounghyun; Larsen, Lesley; Rosengren, Rhonda J; Safe, Stephen (2012. ) Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs.BMC cancer, , 12 ,564

Park, Yun-Yong; Jung, Sung Yun; Jennings, Nicholas B; Rodriguez-Aguayo, Cristian; Peng, Guang; Lee, Se-Ran; Kim, Sang Bae; Kim, Kyounghyun; Leem, Sun-Hee; Lin, Shiaw-Yih; Lopez-Berestein, Gabriel; Sood, Anil K; Lee, Ju-Seog (2012. ) FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair.Carcinogenesis, , 33 (10 ) ,1843-53

Kim, Kyounghyun; Chadalapaka, Gayathri; Pathi, Satya S; Jin, Un-Ho; Lee, Ju-Seog; Park, Yun-Yong; Cho, Sung-Gook; Chintharlapalli, Sudhakar; Safe, Stephen (2012. ) Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters.Molecular cancer therapeutics, , 11 (9 ) ,1852-62

Liu, Xinyi; Jutooru, Indira; Lei, Ping; Kim, KyoungHyun; Lee, Syng-Ook; Brents, Lisa K; Prather, Paul L; Safe, Stephen (2012. ) Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.Molecular cancer therapeutics, , 11 (7 ) ,1421-31

Park, Yun-Yong; Kim, Kyounghyun; Kim, Sang-Bae; Hennessy, Bryan T; Kim, Soo Mi; Park, Eun Sung; Lim, Jae Yun; Li, Jane; Lu, Yiling; Gonzalez-Angulo, Ana Maria; Jeong, Woojin; Mills, Gordon B; Safe, Stephen; Lee, Ju-Seog (2012. ) Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer.EMBO molecular medicine, , 4 (1 ) ,52-67

Zhang, Shu; Kim, KyoungHyun; Jin, Un Ho; Pfent, Catherine; Cao, Huojun; Amendt, Brad; Liu, Xinyi; Wilson-Robles, Heather; Safe, Stephen (2012. ) Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells.Molecular cancer therapeutics, , 11 (1 ) ,108-18

Yoon, Kyungsil; Lee, Syng-Ook; Cho, Sung-Dae; Kim, Kyounghyun; Khan, Shaheen; Safe, Stephen (2011. ) Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors.Carcinogenesis, , 32 (6 ) ,836-42

Kim, Kyounghyun; Burghardt, Robert; Barhoumi, Rola; Lee, Syng-Ook; Liu, Xinyi; Safe, Stephen (2011. ) MDM2 regulates estrogen receptor ? and estrogen responsiveness in breast cancer cells.Journal of molecular endocrinology, , 46 (2 ) ,67-79

Claerhout, Sofie; Lim, Jae Yun; Choi, Woonyoung; Park, Yun-Yong; Kim, Kyounghyun; Kim, Sang-Bae; Lee, Ju-Seog; Mills, Gordon B; Cho, Jae Yong (2011. ) Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer.PloS one, , 6 (9 ) ,e24662

Lee, Syng-Ook; Abdelrahim, Maen; Yoon, Kyungsil; Chintharlapalli, Sudhakar; Papineni, Sabitha; Kim, Kyounghyun; Wang, Huamin; Safe, Stephen (2010. ) Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth.Cancer research, , 70 (17 ) ,6824-36

Li, Xiangrong; Mertens-Talcott, Susanne U; Zhang, Shu; Kim, Kyounghyun; Ball, Judith; Safe, Stephen (2010. ) MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells.Endocrinology, , 151 (6 ) ,2462-73

Wu, Fei; Xu, Rui; Kim, Kyounghyun; Martin, James; Safe, Stephen (2008. ) In vivo profiling of estrogen receptor/specificity protein-dependent transactivation.Endocrinology, , 149 (11 ) ,5696-705

Safe, Stephen; Kim, Kyounghyun; Kim, Kyoungkim (2008. ) Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways.Journal of molecular endocrinology, , 41 (5 ) ,263-75

Naugler, Willscott E; Sakurai, Toshiharu; Kim, Sunhwa; Maeda, Shin; Kim, Kyounghyun; Elsharkawy, Ahmed M; Karin, Michael (2007. ) Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production.Science (New York, N.Y.), , 317 (5834 ) ,121-4

Khan, Shaheen; Barhoumi, Rola; Burghardt, Robert; Liu, Shengxi; Kim, Kyounghyun; Safe, Stephen (2006. ) Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.Molecular endocrinology (Baltimore, Md.), , 20 (9 ) ,2199-214

Abdelrahim, Maen; Ariazi, Eric; Kim, Kyounghyun; Khan, Shaheen; Barhoumi, Rola; Burghardt, Robert; Liu, Shengxi; Hill, Denise; Finnell, Richard; Wlodarczyk, Bogdan; Jordan, V Craig; Safe, Stephen (2006. ) 3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha.Cancer research, , 66 (4 ) ,2459-67

Kim, Kyounghyun; Barhoumi, Rola; Burghardt, Robert; Safe, Stephen (2005. ) Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer.Molecular endocrinology (Baltimore, Md.), , 19 (4 ) ,843-54

Lee, Jeongeun Eun; Kim, Kyounghyun; Sacchettini, James C; Smith, Clare V; Safe, Stephen (2005. ) DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs.The Journal of biological chemistry, , 280 (10 ) ,8819-30

Safe, Stephen; Kim, Kyounghyun (2004. ) Nuclear receptor-mediated transactivation through interaction with Sp proteins.Progress in nucleic acid research and molecular biology, , 77 ,1-36

Kim, Kyounghyun; Thu, Nguyen; Saville, Brad; Safe, Stephen (2003. ) Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells.Molecular endocrinology (Baltimore, Md.), , 17 (5 ) ,804-17

Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, Kim S, Safe S. (2013. ) HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene, , 32 (13 ) ,1616

Yang GY, Liao J, Kim K, Yurkow EJ, Yang CS (1998. ) Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. Carcinogenesis, , 19 (4 ) ,611

Porter W, Wang F, Duan R, Qin C, Castro-Rivera E, Kim K, Safe S. (2001. ) Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists. J Mol Endocrinol., , 26 (1 ) ,31

Safe S, Kim K. (2004. ) Nuclear receptor-mediated transactivation through interaction with Sp proteins. Prog Nucleic Acid Res Mol Biol, , 77 ,1

Gandhy, Shruti U; Imanirad, Parisa; Jin, Un-Ho; Nair, Vijayalekshmi; Hedrick, Eric; Cheng, Yating; Corton, J Christopher; Kim, KyoungHyun; Safe, Stephen (2015. ) Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC. Oncotarget, , 6 (28 ) ,26359-72

Khanal, Tilak; Kim, Dasom; Johnson, Abby; Choubey, Divaker; Kim, Kyounghyun (2015. ) Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter.Toxicology letters, , 237 (3 ) ,228-36

Ko, Seong-Gyu; Yin, Chang Shik; Du, Bing; Kim, KyoungHyun (2014. ) Herbal medicines for inflammatory diseases.Mediators of inflammation, , 2014 ,982635

Khanal, Tilak; Choi, Kwangmin; Leung, Yuet-Kin; Wang, Jiang; Kim, Dasom; Janakiram, Vinothini; Cho, Sung-Gook; Puga, Alvaro; Ho, Shuk-Mei; Kim, Kyounghyun (2017. ) Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer.Scientific reports, , 7 (1 ) ,10662

Contact Information

Academic - University of Cincinnati Department of Environmental Health
Kettering Hall
Phone: 513-558-4851