Chia-I Ko

Chia-I Ko

Adjunct Assistant Professor

Kettering lab complex
Room 439
160 Panzeca Way
Cincinnati, Ohio 45267
Email koci@ucmail.uc.edu

Education

Bachelor's Degree: Taipei Medical University, Taipei city, Taiwan 2001

Master's Degree : University of Lorraine, Nancy, France 2003

Master's Degree: National Polythechnic Institute of Lorraine, Nancy, France 2004

Doctoral Degree: University of Lorraine, Nancy, France 2008

Fellowship: University of Cincinnati Cincinnati, OH, 2015 (Environmental & Public Health Sciences)

Associate Degree: University of Cincinnati Cincinnati, OH, 2018 (Environmental & Public Health Services)

Scientist: University of Cincinnati Cincinnati, OH, 2020 (Environmental & Public Health Sciences)

Positions and Work Experience

05-01-2020 -To Present Adjunct Assistant Professor, University of Cincinnati, Department of Environmental and Public Health Sciences

Research Support

Grant: #R21 ES031190 Investigators:Ko, Chia-I; Puga, Alvaro; Biesiada, Jacek; Zhang, Xiang 07-01-2020 -06-30-2022 NIEHS Disruption of Pluripotency by Dioxin Exposure Role:PI $240,750.00

Grant: #P30 ES006096 Investigators:Chia-I Ko, Alvaro Puga 03-15-2020 -02-28-2021 NIEHS Disruption of Pluripotency and Differentiation of Preimplantation Embryonic Cells by Dioxin Exposure Role:PI $15,000 Active Level:Department

Publications

Peer Reviewed Publications

Ko, Chia-I; Puga, Alvaro (2017. ) Does the Aryl Hydrocarbon Receptor Regulate Pluripotency?.Current opinion in toxicology, , 2 ,1-7 More Information

Ko, Chia-I; Fan, Yunxia; de Gannes, Matthew; Wang, Qin; Xia, Ying; Puga, Alvaro (2016. ) Repression of the Aryl Hydrocarbon Receptor Is Required to Maintain Mitotic Progression and Prevent Loss of Pluripotency of Embryonic Stem Cells.Stem cells (Dayton, Ohio), , 34 (12 ) ,2825-2839 More Information

Wang, Qin; Kurita, Hisaka; Carreira, Vinicius; Ko, Chia-I; Fan, Yunxia; Zhang, Xiang; Biesiada, Jacek; Medvedovic, Mario; Puga, Alvaro (2016. ) Ah Receptor Activation by Dioxin Disrupts Activin, BMP, and WNT Signals During the Early Differentiation of Mouse Embryonic Stem Cells and Inhibits Cardiomyocyte Functions.Toxicological sciences : an official journal of the Society of Toxicology, , 149 (2 ) ,346-57 More Information

Carreira, Vinicius S; Fan, Yunxia; Kurita, Hisaka; Wang, Qin; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Zhang, Xiang; Biesiada, Jacek; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro (2015. ) Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and Function in the Adult.PloS one, , 10 (11 ) ,e0142440 More Information

Carreira, Vinicius S; Fan, Yunxia; Wang, Qing; Zhang, Xiang; Kurita, Hisaka; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro (2015. ) Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes.Toxicological sciences : an official journal of the Society of Toxicology, , 147 (2 ) ,425-35 More Information

Ko, Chia-I; Wang, Qin; Fan, Yunxia; Xia, Ying; Puga, Alvaro (2014. ) Pluripotency factors and Polycomb Group proteins repress aryl hydrocarbon receptor expression in murine embryonic stem cells.Stem cell research, , 12 (1 ) ,296-308 More Information

Qin Wang, Jing Chen, Chia-I Ko, Yunxia Fan, Vinicius Carreira, Yinglei Chen, Ying Xia, Mario Medvedovic, and Alvaro Puga (2013. ) Disruption of Aryl Hydrocarbon Receptor Homeostatic Levels during Embryonic Stem Cell Differentiation Alters Expression of Homeobox Transcription Factors that Control Cardiomyogenesis.Environmental Health Perspectives, , Nov-Dec 2013;121 (11-12 ) ,1334 More Information

Winans, Bethany; Nagari, Anusha; Chae, Minho; Post, Christina M; Ko, Chia-I; Puga, Alvaro; Kraus, W Lee; Lawrence, B Paige (2015. ) Linking the aryl hydrocarbon receptor with altered DNA methylation patterns and developmentally induced aberrant antiviral CD8+ T cell responses.Journal of immunology (Baltimore, Md. : 1950), , 194 (9 ) ,4446-57 More Information

Wang, Qin; Chen, Jing; Ko, Chia-I; Fan, Yunxia; Carreira, Vinicius; Chen, Yinglei; Xia, Ying; Medvedovic, Mario; Puga, Alvaro Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis.Environmental health perspectives, , 121 (11-12 ) ,1334-43 More Information

Wang, Jingcai; Chen, Liang; Ko, Chia-I; Zhang, Lin; Puga, Alvaro; Xia, Ying (2012. ) Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.The Journal of biological chemistry, , 287 (4 ) ,2787-97 More Information

Ko, Chia-I; Chesnel, Amand; Mazerbourg, Sabine; Kuntz, Sandra; Flament, Stéphane; Chardard, Dominique (2008. ) Female-enriched expression of ERalpha during gonad differentiation of the urodele amphibian Pleurodeles waltl.General and comparative endocrinology, , 156 (2 ) ,234-45 More Information

Dumond, Helene; Maufroid, Jean-Pierre; Ko, Chia-I; Chardard, Dominique; Chesnel, Amand; Flament, Stephane (2008. ) Freemartin in the amphibian Pleurodeles waltl: parabiosis between individuals from opposite sex triggers both germ and somatic cells alterations during female gonad development.Molecular reproduction and development, , 75 (3 ) ,439-49 More Information

de Gannes, Matthew; Ko, Chia-I; Zhang, Xiang; Biesiada, Jacek; Niu, Liang; Koch, Sheryl E; Medvedovic, Mario; Rubinstein, Jack; Puga, Alvaro (2020. ) Dioxin Disrupts Dynamic DNA Methylation Patterns in Genes That Govern Cardiomyocyte Maturation.Toxicological sciences : an official journal of the Society of Toxicology, , 178 (2 ) ,325-337 More Information

Zablon, Hesbon A; Ko, Chia-I; Puga, Alvaro (2021. ) Converging Roles of the Aryl Hydrocarbon Receptor in Early Embryonic Development, Maintenance of Stemness, and Tissue Repair.Toxicological sciences : an official journal of the Society of Toxicology, , 182 (1 ) ,1-9 More Information

Book Chapter

Chia-I Ko and Alvaro Puga (2011 ) EPIGENETIC MECHANISMS IN AHR FUNCTION The Ah Receptor in Biology and Toxicology .(pp. 157). John Wiley & Sons, Inc.

Contact Information

Academic - Kettering lab complex
Room 439
Cincinnati  Ohio, 45267
koci@ucmail.uc.edu