Raphael Kopan, Ph.D., PhD

Peer Reviewed Publications

Kopan, Raphael; Chen, Shuang; Liu, Zhenyi  (2014). Alagille, Notch, and robustness: why duplicating systems does not ensure redundancy. Pediatric nephrology (Berlin, Germany), 29 (4) , 651-7More Information

Kopan, Raphael; Chen, Shuang; Little, Melissa  (2014). Nephron progenitor cells: shifting the balance of self-renewal and differentiation. Current topics in developmental biology, 107, 293-331More Information

Boyle, Scott C; Liu, Zhenyi; Kopan, Raphael  (2014). Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development (Cambridge, England), 141 (2) , 346-54More Information

Ilagan, Ma Xenia G; Kopan, Raphael  (2014). Monitoring Notch activation in cultured mammalian cells: luciferase complementation imaging assays. Methods in molecular biology (Clifton, N.J.), 1187, 155-68More Information

Ilagan, Ma Xenia G; Kopan, Raphael  (2014). Monitoring Notch activation in cultured mammalian cells: transcriptional reporter assays. Methods in molecular biology (Clifton, N.J.), 1187, 143-54More Information

Yockey, Laura J; Demehri, Shadmehr; Turkoz, Mustafa; Turkoz, Ahu; Ahern, Philip P; Jassim, Omar; Manivasagam, Sindhu; Kearney, John F; Gordon, Jeffrey I; Kopan, Raphael  (2013). The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. The Journal of investigative dermatology, 133 (12) , 2714-21More Information

Chillakuri, Chandramouli R; Sheppard, Devon; Ilagan, Ma Xenia G; Holt, Laurie R; Abbott, Felicity; Liang, Shaoyan; Kopan, Raphael; Handford, Penny A; Lea, Susan M  (2013). Structural analysis uncovers lipid-binding properties of Notch ligands. Cell reports, 5 (4) , 861-7More Information

Zhao, Zhong-Qiu; Huo, Fu-Quan; Jeffry, Joseph; Hampton, Lori; Demehri, Shadmehr; Kim, Seungil; Liu, Xian-Yu; Barry, Devin M; Wan, Li; Liu, Zhong-Chun; Li, Hui; Turkoz, Ahu; Ma, Kaijie; Cornelius, Lynn A; Kopan, Raphael; Battey, James F; Zhong, Jian; Chen, Zhou-Feng  (2013). Chronic itch development in sensory neurons requires BRAF signaling pathways. The Journal of clinical investigation, 123 (11) , 4769-80More Information

Groot, Arjan J; Cobzaru, Cristina; Weber, Silvio; Saftig, Paul; Blobel, Carl P; Kopan, Raphael; Vooijs, Marc; Franzke, Claus-Werner  (2013). Epidermal ADAM17 is dispensable for notch activation. The Journal of investigative dermatology, 133 (9) , 2286-8More Information

Satpathy, Ansuman T; Briseño, Carlos G; Lee, Jacob S; Ng, Dennis; Manieri, Nicholas A; Kc, Wumesh; Wu, Xiaodi; Thomas, Stephanie R; Lee, Wan-Ling; Turkoz, Mustafa; McDonald, Keely G; Meredith, Matthew M; Song, Christina; Guidos, Cynthia J; Newberry, Rodney D; Ouyang, Wenjun; Murphy, Theresa L; Stappenbeck, Thaddeus S; Gommerman, Jennifer L; Nussenzweig, Michel C; Colonna, Marco; Kopan, Raphael; Murphy, Kenneth M  (2013). Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nature immunology, 14 (9) , 937-48More Information

Liu, Zhenyi; Chen, Shuang; Boyle, Scott; Zhu, Yu; Zhang, Andrew; Piwnica-Worms, David R; Ilagan, Ma Xenia G; Kopan, Raphael  (2013). The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development. Developmental cell, 25 (6) , 585-98More Information

Liu, Zhiyong; Liu, Zhenyi; Walters, Bradley J; Owen, Thomas; Kopan, Raphael; Zuo, Jian  (2013). In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea. PloS one, 8 (5) , e64903More Information

Ilagan, Ma Xenia G; Kopan, Raphael  (2013). Selective blockade of transport via SERCA inhibition: the answer for oncogenic forms of Notch?. Cancer cell, 23 (3) , 267-9More Information

Morimoto, Mitsuru; Nishinakamura, Ryuichi; Saga, Yumiko; Kopan, Raphael  (2012). Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells. Development (Cambridge, England), 139 (23) , 4365-73More Information

Demehri, Shadmehr; Turkoz, Ahu; Manivasagam, Sindhu; Yockey, Laura J; Turkoz, Mustafa; Kopan, Raphael  (2012). Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer cell, 22 (4) , 494-505More Information

Kopan, Raphael  (2012). Notch signaling. Cold Spring Harbor perspectives in biology, 4 (10) More Information

Barak, Hila; Huh, Sung-Ho; Chen, Shuang; Jeanpierre, Cécile; Martinovic, Jelena; Parisot, Mélanie; Bole-Feysot, Christine; Nitschké, Patrick; Salomon, Rémi; Antignac, Corinne; Ornitz, David M; Kopan, Raphael  (2012). FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Developmental cell, 22 (6) , 1191-207More Information

Zheng, Jin; Watanabe, Hirotaka; Wines-Samuelson, Mary; Zhao, Huailong; Gridley, Thomas; Kopan, Raphael; Shen, Jie  (2012). Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. The Journal of biological chemistry, 287 (24) , 20356-68More Information

Mascia, Francesca; Denning, Mitchell; Kopan, Raphael; Yuspa, Stuart H  (2012). The black box illuminated: signals and signaling. The Journal of investigative dermatology, 132 (3 Pt 2) , 811-9More Information

Tu, Xiaolin; Chen, Jianquan; Lim, Joohyun; Karner, Courtney M; Lee, Seung-Yon; Heisig, Julia; Wiese, Cornelia; Surendran, Kameswaran; Kopan, Raphael; Gessler, Manfred; Long, Fanxin  (2012). Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS genetics, 8 (3) , e1002577More Information

Sato, Chihiro; Turkoz, Mustafa; Dearborn, Joshua T; Wozniak, David F; Kopan, Raphael; Hass, Matthew R  (2012). Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice. PloS one, 7 (10) , e48180More Information

Lee, Jacob S; Cella, Marina; McDonald, Keely G; Garlanda, Cecilia; Kennedy, Gregory D; Nukaya, Manabu; Mantovani, Alberto; Kopan, Raphael; Bradfield, Christopher A; Newberry, Rodney D; Colonna, Marco  (2012). AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nature immunology, 13 (2) , 144-51More Information

Boyle, Scott C; Kim, Mijin; Valerius, M Todd; McMahon, Andrew P; Kopan, Raphael  (2011). Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development (Cambridge, England), 138 (19) , 4245-54More Information

Vooijs, Marc; Liu, Zhenyi; Kopan, Raphael  (2011). Notch: architect, landscaper, and guardian of the intestine. Gastroenterology, 141 (2) , 448-59More Information

Ilagan, Ma Xenia G; Lim, Sora; Fulbright, Mary; Piwnica-Worms, David; Kopan, Raphael  (2011). Real-time imaging of notch activation with a luciferase complementation-based reporter. Science signaling, 4 (181) , rs7More Information

Surendran, Kameswaran; Kopan, Raphael  (2011). Chromatin-based mechanisms of renal epithelial differentiation. Journal of the American Society of Nephrology : JASN, 22 (7) , 1208-12More Information

Raphael, Kopan  (2011). Deuterium reveals the dynamics of notch activation. Structure (London, England : 1993), 19 (4) , 443-4More Information

Pellegrinet, Luca; Rodilla, Veronica; Liu, Zhenyi; Chen, Shuang; Koch, Ute; Espinosa, Lluis; Kaestner, Klaus H; Kopan, Raphael; Lewis, Julian; Radtke, Freddy  (2011). Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology, 140 (4) , 1230-1240.e1-7More Information

Liu, Zhenyi; Turkoz, Ahu; Jackson, Erin N; Corbo, Joseph C; Engelbach, John A; Garbow, Joel R; Piwnica-Worms, David R; Kopan, Raphael  (2011). Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. The Journal of clinical investigation, 121 (2) , 800-8More Information

Arnett, Kelly L; Hass, Matthew; McArthur, Debbie G; Ilagan, Ma Xenia G; Aster, Jon C; Kopan, Raphael; Blacklow, Stephen C  (2010). Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nature structural & molecular biology, 17 (11) , 1312-7More Information

Liu, Zhenyi; Schneider, Daniel L; Kornfeld, Kerry; Kopan, Raphael  (2010). Simple copy number determination with reference query pyrosequencing (RQPS). Cold Spring Harbor protocols, 2010 (9) , pdb.prot5491

Tong, Youren; Yamaguchi, Hiroo; Giaime, Emilie; Boyle, Scott; Kopan, Raphael; Kelleher, Raymond J; Shen, Jie  (2010). Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proceedings of the National Academy of Sciences of the United States of America, 107 (21) , 9879-84More Information

Costantini, Frank; Kopan, Raphael  (2010). Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Developmental cell, 18 (5) , 698-712More Information

Surendran, Kameswaran; Selassie, Meron; Liapis, Helen; Krigman, Hannah; Kopan, Raphael  (2010). Reduced Notch signaling leads to renal cysts and papillary microadenomas. Journal of the American Society of Nephrology : JASN, 21 (5) , 819-32More Information

Johnson, Scott E; Ilagan, M Xenia G; Kopan, Raphael; Barrick, Doug  (2010). Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2. The Journal of biological chemistry, 285 (9) , 6681-92More Information

Dumortier, Alexis; Durham, André-Dante; Di Piazza, Matteo; Vauclair, Sophie; Koch, Ute; Ferrand, Gisèle; Ferrero, Isabel; Demehri, Shadmehr; Song, Lynda Li; Farr, Andrew G; Leonard, Warren J; Kopan, Raphael; Miele, Lucio; Hohl, Daniel; Finke, Daniela; Radtke, Freddy  (2010). Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PloS one, 5 (2) , e9258More Information

Zhao, Guojun; Liu, Zhenyi; Ilagan, Ma Xenia G; Kopan, Raphael  (2010). Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30 (5) , 1648-56More Information

Surendran, Kameswaran; Boyle, Scott; Barak, Hila; Kim, Mijin; Stomberski, Colin; McCright, Brent; Kopan, Raphael  (2010). The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Developmental biology, 337 (2) , 386-95More Information

Morimoto, Mitsuru; Liu, Zhenyi; Cheng, Hui-Teng; Winters, Niki; Bader, David; Kopan, Raphael  (2010). Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. Journal of cell science, 123 (Pt 2) , 213-24More Information

Bazzi, Hisham; Demehri, Shadmehr; Potter, Christopher S; Barber, Alison G; Awgulewitsch, Alexander; Kopan, Raphael; Christiano, Angela M  (2009). Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation. Differentiation; research in biological diversity, 78 (5) , 292-300More Information

van Tetering, Geert; van Diest, Paul; Verlaan, Ingrid; van der Wall, Elsken; Kopan, Raphael; Vooijs, Marc  (2009). Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. The Journal of biological chemistry, 284 (45) , 31018-27More Information

Liu, Zhenyi; Obenauf, Anna C; Speicher, Michael R; Kopan, Raphael  (2009). Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS). Genome research, 19 (11) , 2081-9More Information

Riesenberg, Amy N; Liu, Zhenyi; Kopan, Raphael; Brown, Nadean L  (2009). Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29 (41) , 12865-77More Information

Cras-Méneur, Corentin; Li, Lin; Kopan, Raphael; Permutt, M Alan  (2009). Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. Genes & development, 23 (17) , 2088-101More Information

Demehri, Shadmehr; Turkoz, Ahu; Kopan, Raphael  (2009). Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer cell, 16 (1) , 55-66More Information

Demehri, Shadmehr; Morimoto, Mitsuru; Holtzman, Michael J; Kopan, Raphael  (2009). Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS biology, 7 (5) , e1000067More Information

Kopan, Raphael; Ilagan, Maria Xenia G  (2009). The canonical Notch signaling pathway: unfolding the activation mechanism. Cell, 137 (2) , 216-33More Information

Hass, Matthew R; Sato, Chihiro; Kopan, Raphael; Zhao, Guojun  (2009). Presenilin: RIP and beyond. Seminars in cell & developmental biology, 20 (2) , 201-10More Information

Demehri, Shadmehr; Kopan, Raphael  (2009). Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development (Cambridge, England), 136 (6) , 891-6More Information

Cai, Jing; Lee, Jonghyeob; Kopan, Raphael; Ma, Liang  (2009). Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation. Developmental biology, 326 (2) , 420-30More Information

Morimoto, Mitsuru; Kopan, Raphael  (2009). rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Developmental biology, 325 (1) , 171-8More Information

Ong, Chin-Tong; Sedy, John R; Murphy, Kenneth M; Kopan, Raphael  (2008). Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PloS one, 3 (7) , e2823More Information

Demehri, Shadmehr; Liu, Zhenyi; Lee, Jonghyeob; Lin, Meei-Hua; Crosby, Seth D; Roberts, Christopher J; Grigsby, Perry W; Miner, Jeffrey H; Farr, Andrew G; Kopan, Raphael  (2008). Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS biology, 6 (5) , e123More Information

Bai, Shuting; Kopan, Raphael; Zou, Wei; Hilton, Matthew J; Ong, Chin-tong; Long, Fanxin; Ross, F Patrick; Teitelbaum, Steven L  (2008). NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. The Journal of biological chemistry, 283 (10) , 6509-18More Information

Hilton, Matthew J; Tu, Xiaolin; Wu, Ximei; Bai, Shuting; Zhao, Haibo; Kobayashi, Tatsuya; Kronenberg, Henry M; Teitelbaum, Steven L; Ross, F Patrick; Kopan, Raphael; Long, Fanxin  (2008). Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nature medicine, 14 (3) , 306-14More Information

Lee, Jonghyeob; Wu, Wei; Kopan, Raphael  (2008). Murine vibrissae cultured in serum-free medium reinitiate anagen. The Journal of investigative dermatology, 128 (2) , 482-5More Information

Khandelwal, Abha; Chandu, Dilip; Roe, Catherine M; Kopan, Raphael; Quatrano, Ralph S  (2007). Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved. Proceedings of the National Academy of Sciences of the United States of America, 104 (33) , 13337-42More Information

Lee, Jonghyeob; Basak, Jacob M; Demehri, Shadmehr; Kopan, Raphael  (2007). Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development (Cambridge, England), 134 (15) , 2795-806More Information

Kopan, Raphael; Cheng, Hui-Teng; Surendran, Kameswaran  (2007). Molecular insights into segmentation along the proximal-distal axis of the nephron. Journal of the American Society of Nephrology : JASN, 18 (7) , 2014-20More Information

Ilagan, Maria Xenia G; Kopan, Raphael  (2007). SnapShot: notch signaling pathway. Cell, 128 (6) , 1246More Information

Cheng, Hui-Teng; Kim, Mijin; Valerius, M Todd; Surendran, Kameswaran; Schuster-Gossler, Karin; Gossler, Achim; McMahon, Andrew P; Kopan, Raphael  (2007). Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (Cambridge, England), 134 (4) , 801-11More Information

Vooijs, Marc; Ong, Chin-Tong; Hadland, Brandon; Huppert, Stacey; Liu, Zhenyi; Korving, Jeroen; van den Born, Maaike; Stappenbeck, Thaddeus; Wu, Yumei; Clevers, Hans; Kopan, Raphael  (2007). Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (Cambridge, England), 134 (3) , 535-44More Information

Lubman, Olga Y; Ilagan, Ma Xenia G; Kopan, Raphael; Barrick, Doug  (2007). Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch. Journal of molecular biology, 365 (3) , 577-89More Information

Weinmaster, Gerry; Kopan, Raphael  (2006). A garden of Notch-ly delights. Development (Cambridge, England), 133 (17) , 3277-82More Information

Ogura, Toshihiko; Mio, Kazuhiro; Hayashi, Ikuo; Miyashita, Hiroyuki; Fukuda, Rie; Kopan, Raphael; Kodama, Tatsuhiko; Hamakubo, Takao; Iwatsubo, Takeshi; Iwastubo, Takeshi; Tomita, Taisuke; Sato, Chikara  (2006). Three-dimensional structure of the gamma-secretase complex. Biochemical and biophysical research communications, 343 (2) , 525-34More Information

Keller, Preston C; Tomita, Taisuke; Hayashi, Ikuo; Chandu, Dilip; Weber, Jason D; Cistola, David P; Kopan, Raphael  (2006). A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates. Biochemistry, 45 (16) , 5351-8More Information

Barrick, Doug; Kopan, Raphael  (2006). The Notch transcription activation complex makes its move. Cell, 124 (5) , 883-5More Information

Ong, Chin-Tong; Cheng, Hui-Teng; Chang, Li-Wei; Ohtsuka, Toshiyuki; Kageyama, Ryoichiro; Stormo, Gary D; Kopan, Raphael  (2006). Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. The Journal of biological chemistry, 281 (8) , 5106-19More Information

Yang, Xudong; Tomita, Taisuke; Wines-Samuelson, Mary; Beglopoulos, Vassilios; Tansey, Malú G; Kopan, Raphael; Shen, Jie  (2006). Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. Developmental neuroscience, 28 (1-2) , 102-17More Information

Chandu, Dilip; Huppert, Stacey S; Kopan, Raphael  (2006). Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase. Journal of neurochemistry, 96 (1) , 228-35More Information

Cheng, Hui-Teng; Kopan, Raphael  (2005). The role of Notch signaling in specification of podocyte and proximal tubules within the developing mouse kidney. Kidney international, 68 (5) , 1951-2More Information

Pan, Yonghua; Liu, Zhenyi; Shen, Jie; Kopan, Raphael  (2005). Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Developmental biology, 286 (2) , 472-82More Information

Kiernan, Amy E; Cordes, Ralf; Kopan, Raphael; Gossler, Achim; Gridley, Thomas  (2005). The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development (Cambridge, England), 132 (19) , 4353-62More Information

Huppert, Stacey S; Ilagan, Ma Xenia G; De Strooper, Bart; Kopan, Raphael  (2005). Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Developmental cell, 8 (5) , 677-88More Information

Lubman, Olga Y; Kopan, Raphael; Waksman, Gabriel; Korolev, Sergey  (2005). The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold. Protein science : a publication of the Protein Society, 14 (5) , 1274-81More Information

Vooijs, Marc; Schroeter, Eric H; Pan, Yonghua; Blandford, Mary; Kopan, Raphael  (2004). Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. The Journal of biological chemistry, 279 (49) , 50864-73More Information

Hadland, Brandon K; Huppert, Stacey S; Kanungo, Jyotshnabala; Xue, Yingzi; Jiang, Rulang; Gridley, Thomas; Conlon, Ronald A; Cheng, Alec M; Kopan, Raphael; Longmore, Gregory D  (2004). A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood, 104 (10) , 3097-105More Information

Pan, Yonghua; Lin, Meei-Hua; Tian, Xiaolin; Cheng, Hui-Teng; Gridley, Thomas; Shen, Jie; Kopan, Raphael  (2004). gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Developmental cell, 7 (5) , 731-43More Information

Nichols, Amy M; Pan, Yonghua; Herreman, An; Hadland, Brandon K; De Strooper, Bart; Kopan, Raphael; Huppert, Stacey S  (2004). Notch pathway is dispensable for adipocyte specification. Genesis (New York, N.Y. : 2000), 40 (1) , 40-4More Information

Wolfe, Michael S; Kopan, Raphael  (2004). Intramembrane proteolysis: theme and variations. Science (New York, N.Y.), 305 (5687) , 1119-23More Information

Koo, Edward H; Kopan, Raphael  (2004). Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nature medicine, 10 Suppl, S26-33More Information

Kopan, Raphael; Ilagan, Ma Xenia G  (2004). Gamma-secretase: proteasome of the membrane?. Nature reviews. Molecular cell biology, 5 (6) , 499-504More Information

Yang, Xudong; Klein, Rüdiger; Tian, Xiaolin; Cheng, Hui-Teng; Kopan, Raphael; Shen, Jie  (2004). Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Developmental biology, 269 (1) , 81-94More Information

Lubman, Olga Y; Korolev, Sergey V; Kopan, Raphael  (2004). Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. Molecular cell, 13 (5) , 619-26

Lin, Meei-Hua; Kopan, Raphael  (2003). Long-range, nonautonomous effects of activated Notch1 on tissue homeostasis in the nail. Developmental biology, 263 (2) , 343-59

Schroeter, Eric H; Ilagan, Ma Xenia G; Brunkan, Anne L; Hecimovic, Silva; Li, Yue-ming; Xu, Min; Lewis, Huw D; Saxena, Meera T; De Strooper, Bart; Coonrod, Archie; Tomita, Taisuke; Iwatsubo, Takeshi; Moore, Chad L; Goate, Alison; Wolfe, Michael S; Shearman, Mark; Kopan, Raphael  (2003). A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America, 100 (22) , 13075-80More Information

Hu, Qi-Dong; Ang, Beng-Ti; Karsak, Meliha; Hu, Wei-Ping; Cui, Xiao-Ying; Duka, Tanya; Takeda, Yasuo; Chia, Wendy; Sankar, Natesan; Ng, Yee-Kong; Ling, Eng-Ang; Maciag, Thomas; Small, Deena; Trifonova, Radianna; Kopan, Raphael; Okano, Hideyuki; Nakafuku, Masato; Chiba, Shigeru; Hirai, Hisamaru; Aster, Jon C; Schachner, Melitta; Pallen, Catherine J; Watanabe, Kazutada; Xiao, Zhi-Cheng  (2003). F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell, 115 (2) , 163-75

Cheng, Hui-Teng; Miner, Jeffrey H; Lin, MeeiHua; Tansey, Malú G; Roth, Kevin; Kopan, Raphael  (2003). Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development (Cambridge, England), 130 (20) , 5031-42More Information

Selkoe, Dennis; Kopan, Raphael  (2003). Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annual review of neuroscience, 26, 565-97More Information

Michelson, Alan; Kopan, Raphael  (2002). Differentiation and gene regulation: toward a holistic understanding of animal development: intercellular communication and transcriptional regulation are two sides of the same coin. Current opinion in genetics & development, 12 (5) , 499-502

Kopan, Raphael  (2002). Notch: a membrane-bound transcription factor. Journal of cell science, 115 (Pt 6) , 1095-7

Kopan, Raphael; Lee, Jonghyeob; Lin, Meei-Hua; Syder, Andrew J; Kesterson, John; Crutchfield, Neil; Li, Caroline R; Wu, Wei; Books, Jason; Gordon, Jeffrey I  (2002). Genetic mosaic analysis indicates that the bulb region of coat hair follicles contains a resident population of several active multipotent epithelial lineage progenitors. Developmental biology, 242 (1) , 44-57More Information

Kopan, Raphael; Goate, Alison  (2002). Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization. Neuron, 33 (3) , 321-4

Liu, Zhenyi; Schneider, Daniel L; Kornfeld, Kerry; Kopan, Raphael  (2015). Corrigendum: Simple Copy Number Determination with Reference Query Pyrosequencing (RQPS). Cold Spring Harbor protocols, 2015 (10) , pdb.corr090167More Information

Hass, Matthew R; Liow, Hien-Haw; Chen, Xiaoting; Sharma, Ankur; Inoue, Yukiko U; Inoue, Takayoshi; Reeb, Ashley; Martens, Andrew; Fulbright, Mary; Raju, Saravanan; Stevens, Michael; Boyle, Scott; Park, Joo-Seop; Weirauch, Matthew T; Brent, Michael R; Kopan, Raphael  (2015). SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers. Molecular cell, 59 (4) , 685-97More Information

Demitrack, Elise S; Gifford, Gail B; Keeley, Theresa M; Carulli, Alexis J; VanDussen, Kelli L; Thomas, Dafydd; Giordano, Thomas J; Liu, Zhenyi; Kopan, Raphael; Samuelson, Linda C  (2015). Notch signaling regulates gastric antral LGR5 stem cell function. The EMBO journal, 34 (20) , 2522-36More Information

Liu, Zhenyi; Brunskill, Eric; Varnum-Finney, Barbara; Zhang, Chi; Zhang, Andrew; Jay, Patrick Y; Bernstein, Irv; Morimoto, Mitsuru; Kopan, Raphael  (2015). The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development (Cambridge, England), 142 (14) , 2452-63More Information

Liu, Zhenyi; Brunskill, Eric; Boyle, Scott; Chen, Shuang; Turkoz, Mustafa; Guo, Yuxuan; Grant, Rachel; Kopan, Raphael  (2015). Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity. Development (Cambridge, England), 142 (6) , 1193-202More Information

raphael.kopan@cchmc.org