Elizabeth Kopras

Elizabeth J Kopras

Sr Research Associate

Medical Sciences Building


COM IM Pulmonary Clinical Research - 0564


BA: Ohio University Athens, OH, 1987 (Psychology, Summa Cum Laude in 3 years)

Ohio University Athens, OH, 1990 (Experimental Psychology/Zoological and Biomedical Sciences)

University of Cincinnati Cincinnati, OH, 2000 (Molecular Genetics)

Ph.D.: University of Cincinnati Cincinnati, OH, 2013 ((ABD))

Research and Practice Interests

I manage programs across a spectrum of needs including scientific promotion, research program design and implementation, strategic planning, and financial tracking. 

I have a variety of scientific interests, which is why I decided to pursue a PhD in epidemiology. I have studied a number of disorders including smooth muscle cell proliferation in heart disease, DNA repair in ataxia telangiectasia, second messenger signalling in pancreatic cancer, and protein folding in hereditary pancreatitis. I am interested in the application of large data set information to appropriately inform clinical decisions and health/environmental policies. Biostatistical ethics and reproducible data are, therefore, important areas of research to me. I am also interested in cost-efficient ways to improve health outcomes, such as diet and stress. 

I love teaching and explaining ideas--seeing the change on a person's face when they finally 'get' a concept. I especially enjoying teaching scientific writing (including grant writing), basic biostatistics, and biomedical and statistical ethics. 

My passion for writing includes communicating scientific concepts to the general public, and listening to people in order to understand what they want to know. I have learned, through my work with Dr. Erin Haynes, to also listen to communities, and to value the expertise that they bring to me.

Specialties: Some people are creative, some people can spin, and some people know science, but few can combine all three. I make grants better. I bring seventeen years of benchwork, including molecular biology and small animal surgery, as part of my experiential package. Expert in experimental design, career development programs, and some expertise in the design and analysis of human research studies.

Positions and Work Experience

07-01-2013 - Senior Research Associate, Organizing scientific meetings and events; strategizing and coordinating collection, storage and documentation of clinical biospecimens; assist in clinical trials design, management and analysis; produce educational materials for patients and clinicians; organize, write, and submit grant applications; provide mentorship for graduate students, postdoctoral fellows, and early career faculty on program management, research design, grant submissions and publications. , University of Cincinnati, Cincinnati, OH

Research Support

Investigators:Kopras, Elizabeth 05-01-2021 -04-30-2025 Department of Veterans Affairs VA IPA - Kopras Role:PI 0.00 Hold Level:Federal


Peer Reviewed Publications

Oster, Robert A; Lindsell, Christopher J; Welty, Leah J; Mazumdar, Madhu; Thurston, Sally W; Rahbar, Mohammad H; Carter, Rickey E; Pollock, Bradley H; Cucchiara, Andrew J; Kopras, Elizabeth J; Jovanovic, Borko D; Enders, Felicity T (2015. ) Assessing statistical competencies in clinical and translational science education: one size does not fit all.Clinical and translational science, , 8 (1 ) ,32-42 More Information

Haynes, Erin N; Beidler, Caroline; Wittberg, Richard; Meloncon, Lisa; Parin, Megan; Kopras, Elizabeth J; Succop, Paul; Dietrich, Kim N (2011. ) Developing a bidirectional academic-community partnership with an Appalachian-American community for environmental health research and risk communication.Environmental health perspectives, , 119 (10 ) ,1364-72 More Information

Kopras, Elizabeth; Potluri, Veena; Bermudez, Mei-Ling; Williams, Karin; Belcher, Scott; Kasper, Susan (2014. ) Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease.Endocrine-related cancer, , 21 (2 ) ,T1-12 More Information

Dwivedi, Alok Kumar; Dwivedi, Sada Nand; Deo, Suryanarayana; Shukla, Rakesh; Kopras, Elizabeth (2010. ) Statistical models for predicting number of involved nodes in breast cancer patients.Health, , 2 (7 ) ,641-651 More Information

Dixon, Kathleen; Kopras, Elizabeth (2004. ) Genetic alterations and DNA repair in human carcinogenesis.Seminars in cancer biology, , 14 (6 ) ,441-8 More Information

Ulrich, C D; Kopras, E; Wu, Y; Ward, S (2000. ) Hereditary pancreatitis: epidemiology, molecules, mutations, and models.The Journal of laboratory and clinical medicine, , 136 (4 ) ,260-74 More Information

Ulrich, C D; Wood, P; Hadac, E M; Kopras, E; Whitcomb, D C; Miller, L J (1998. ) Cellular distribution of secretin receptor expression in rat pancreas. The American journal of physiology, , 275 (6 Pt 1 ) ,G1437-44

Jiang, S; Kopras, E; McMichael, M; Bell, R H; Ulrich, C D (1997. ) Vasoactive intestinal peptide (VIP) stimulates in vitro growth of VIP-1 receptor-bearing human pancreatic adenocarcinoma-derived cells. Cancer research, , 57 (8 ) ,1475-80

Katoh, Y; Loukianov, E; Kopras, E; Zilberman, A; Periasamy, M (1994. ) Identification of functional promoter elements in the rabbit smooth muscle myosin heavy chain gene. The Journal of biological chemistry, , 269 (48 ) ,30538-45

Gupta, Nishant; Kopras, Elizabeth J; Henske, Elizabeth P; James, Laura E; El-Chemaly, Souheil; Veeraraghavan, Srihari; Drake, Matthew G; McCormack, Francis X (2017. ) Spontaneous Pneumothoraces in Patients with Birt-Hogg-Dubé Syndrome.Annals of the American Thoracic Society, , 14 (5 ) ,706-713 More Information

Lu, Calvin; Lee, Hye-Seung; Pappas, George P; Dilling, Daniel F; Burger, Charles D; Shifren, Adrian; Veeraraghavan, Srihari; Chapman, Jeffrey T; Parambil, Joseph; Ruoss, Stephen J; Young, Lisa R; Hammes, Stephen R; Kopras, Elizabeth J; Roads, Tammy; Krischer, Jeffrey P; McCormack, Francis X (2017. ) A Phase II Clinical Trial of an Aromatase Inhibitor for Postmenopausal Women with Lymphangioleiomyomatosis.Annals of the American Thoracic Society, , 14 (6 ) ,919-928 More Information

Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kohei; Li, Na; Kopras, Elizabeth J; Kwiatkowski, David J; Borchers, Michael T; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Mays, Maxwell; Sun, Yang; Plas, David R; Sun, Julia L; Franz, David N; Capal, Jamie K; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J (2017. ) Tuberin Regulates Prostaglandin Receptor-mediated Viability, via Rheb, in mTORC1-hyperactive Cells.Molecular cancer research : MCR, , More Information

Eckman, Mark H; Kopras, Elizabeth J; Montag-Leifling, Karen; Kirby, Lari P; Burns, Lisa; Indihar, Veronica M; Joseph, Patricia M (2017. ) Shared Decision-Making Tool for Self-Management of Home Therapies for Patients With Cystic Fibrosis.MDM policy & practice, , 2 (1 ) ,2381468317715621 More Information

Jönsson, Åsa Lina M; Bendstrup, Elisabeth; Mogensen, Susie; Kopras, Elizabeth J; McCormack, Francis X; Campo, Ilaria; Mariani, Francesca; Escribano-Montaner, Amparo; Holm, Are M; Del Mar Martinez-Colls, Maria; Pintos-Morell, Guillem; Taillé, Camille; Crestani, Bruno; Hilberg, Ole; Hvarregaard Christensen, Jane; Simonsen, Ulf (2019. ) Eight novel variants in the SLC34A2 gene in pulmonary alveolar microlithiasis.The European respiratory journal, , More Information

Singla, Abhishek; Kopras, Elizabeth J; Gupta, Nishant (2019. ) Spontaneous pneumothorax and air travel in Pulmonary Langerhans cell histiocytosis: A patient survey.Respiratory investigation, , 57 (6 ) ,582-589 More Information

Hudock, Kristin M; Collins, Margaret S; Imbrogno, Michelle; Snowball, John; Kramer, Elizabeth L; Brewington, John J; Gollomp, Kandace; McCarthy, Cormac; Ostmann, Alicia J; Kopras, Elizabeth J; Davidson, Cynthia R; Srdiharan, Anusha; Arumugam, Paritha; Sengupta, Shaon; Xu, Yan; Worthen, G Scott; Trapnell, Bruce C; Clancy, John Paul (2020. ) Neutrophil extracellular traps activate IL-8 and IL-1 expression in human bronchial epithelia.American journal of physiology. Lung cellular and molecular physiology, , More Information

Lu, Yiyang; Liu, Xiaolei; Zhang, Erik; Kopras, Elizabeth J; Smith, Eric P; Astreinidis, Aristotelis; Li, Chenggang; Leung, Yuet-Kin; Ho, Shuk-Mei; Yu, Jane J (2020. ) Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells.PloS one, , 15 (2 ) ,e0228894 More Information

Guo, Minzhe; Yu, Jane J; Perl, Anne Karina; Wikenheiser-Brokamp, Kathryn A; Riccetti, Matt; Zhang, Erik Y; Sudha, Parvathi; Adam, Mike; Potter, Andrew; Kopras, Elizabeth J; Giannikou, Krinio; Potter, S Steven; Sherman, Sue; Hammes, Stephen R; Kwiatkowski, David J; Whitsett, Jeffrey A; McCormack, Francis X; Xu, Yan (2020. ) Single Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.American journal of respiratory and critical care medicine, , More Information

Cortinas, Noella; Liu, Jie; Kopras, Elizabeth; Memon, Humna; Burkes, Robert; Gupta, Nishant (2022. ) Impact of Age, Menopause, and Sirolimus on Spontaneous Pneumothoraces in Lymphangioleiomyomatosis.Chest, , More Information

Shaw, Brian M; Kopras, Elizabeth; Gupta, Nishant (2022. ) Menstrual Cycle-Related Respiratory Symptom Variability in Patients with Lymphangioleiomyomatosis.Annals of the American Thoracic Society, , More Information

Jose, Arun; Kopras, Elizabeth J; Shah, Shimul A; Elwing, Jean M (2022. ) Portopulmonary Hypertension Practice Patterns after Liver Transplantation.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, , More Information

Gupta, Nishant; Zhang, Bin; Zhou, Yuan; McCormack, Francis X; Ingledue, Rebecca; Robbins, Nathan; Kopras, Elizabeth J; McMahan, Susan; Singla, Abhishek; Swigris, Jeffrey; Cole, Adam G; Holz, Marina K (2023. ) Safety and efficacy of combined resveratrol and sirolimus in lymphangioleiomyomatosis.Chest, , More Information

Hudock, K M; Collins, M S; Imbrogno, M A; Kramer, E L; Brewington, J J; Ziady, A; Zhang, N; Snowball, J; Xu, Y; Carey, B C; Horio, Y; O'Grady, S M; Kopras, E J; Meeker, J; Morgan, H; Ostmann, A J; Skala, E; Siefert, M E; Na, C L; Davidson, C R; Gollomp, K; Mangalmurti, N; Trapnell, B C; Clancy, J P (2022. ) Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.Frontiers in immunology, , 13 ,1023553 More Information

Du, Yina; Guo, Minzhe; Wu, Yixin; Wagner, Andrew; Perl, Anne Karina; Wikenheiser-Brokamp, Kathryn; Yu, Jane; Gupta, Nishant; Kopras, Elizabeth; Krymskaya, Vera; Obraztsova, Kseniya; Tang, Yan; Kwiatkowski, David; Henske, Elizabeth P; McCormack, Francis; Xu, Yan (2023. ) Lymphangioleiomyomatosis (LAM) Cell Atlas.Thorax, , 78 (1 ) ,85-87 More Information

Olatoke, Tasnim; Wagner, Andrew; Astrinidis, Aristotelis; Zhang, Erik Y; Guo, Minzhe; Zhang, Alan G; Mattam, Ushodaya; Kopras, Elizabeth J; Gupta, Nishant; Smith, Eric P; Karbowniczek, Magdalena; Markiewski, Maciej M; Wikenheiser-Brokamp, Kathryn A; Whitsett, Jeffrey A; McCormack, Francis X; Xu, Yan; Yu, Jane J (2023. ) Single-cell multiomic analysis identifies a HOX-PBX gene network regulating the survival of lymphangioleiomyomatosis cells.Science advances, , 9 (19 ) ,eadf8549 More Information

Astrinidis, Aristotelis; Li, Chenggang; Zhang, Erik Y; Zhao, Xueheng; Zhao, Shuyang; Guo, Minzhe; Olatoke, Tasnim; Mattam, Ushodaya; Huang, Rong; Zhang, Alan G; Pitstick, Lori; Kopras, Elizabeth J; Gupta, Nishant; Jandarov, Roman; Smith, Eric P; Fugate, Elizabeth; Lindquist, Diana; Markiewski, Maciej M; Karbowniczek, Magdalena; Wikenheiser-Brokamp, Kathryn A; Setchell, Kenneth D R; McCormack, Francis X; Xu, Yan; Yu, Jane J (2023. ) Upregulation of acid ceramidase contributes to tumor progression in tuberous sclerosis complex.JCI insight, , 8 (9 ) , More Information

Uehara, Yasuaki; Tanaka, Yusuke; Zhao, Shuyang; Nikolaidis, Nikolaos M; Pitstick, Lori B; Wu, Huixing; Yu, Jane J; Zhang, Erik; Hasegawa, Yoshihiro; Noel, John G; Gardner, Jason C; Kopras, Elizabeth J; Haffey, Wendy D; Greis, Kenneth D; Guo, Jinbang; Woods, Jason C; Wikenheiser-Brokamp, Kathryn A; Kyle, Jennifer E; Ansong, Charles; Teitelbaum, Steven L; Inoue, Yoshikazu; Altinişik, Göksel; Xu, Yan; McCormack, Francis X (2023. ) Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis.Nature communications, , 14 (1 ) ,1205 More Information

Additional Publications


Superfund Basic Research Program, Pancreatic Cancer, Hereditary Pancreatitis, Micro Surgery

Other Information

Student projects are available in rare lung disease research. ,