Jennifer L McGuire, PhD

BS: University of Massachusetts Amherst, 1994 (Biology/Anthropology)

PhD: University of Cincinnati Cincinnati, OH, 2009 (Molecular and Developmental Biology)

Grant: #2017 Grant Investigators:McGuire, Jennifer; Ngwenya, Laura 09-01-2017 -08-31-2019 Local Initiative for Excellence (L.I.F.E.) Identifying the genetic risk underlying poor cognitive recovery after traumatic brain injury Role:Collaborator $50,000.00 Completed

Grant: #00010319 Investigators:Evanson and McGuire 12-01-2018 -11-30-2020 NIH NCMRR The effects of methylphenidate on brain metabolomics and behavioral outcomes in a rat model of chronic traumatic brain injury Role:Co-Investigator $200,000 Active Type:Grant Level:National

Grant: #DM190198 Investigators:McGuire JL, Goodman MD, Hartings J, Ngwenya LB 04-01-2020 -03-31-2023 Department of Defense Rapid Ketone Infusion to Prevent Brain Energy Depletion and Secondary Brain Injury in Severe TBI with Hemorrhagic Shock Role:Principal Investigator $1,000,000 Pending Type:Grant

Grant: #00013596 Investigators:Robson, Starczynowski, McGuire NIH NINDS Astrocytic IL-1R Signaling Following Traumatic Brain Injury Role:Co-Investigator Planned/In Preparation Type:Grant

Grant: #306133 / R03HD097689 Investigators:McGuire, Jennifer 01-01-2019 -12-31-2020 National Institute of Child Health and Human Development The effects of methylphenidate on brain metabolomics and behavioral outcomes in a rat model of chronic traumatic brain injury Role:PI $69,345.00 Active Level:Federal

Grant: #W81XWH-20-1-0830 Investigators:Goodman, Michael; Hartings, Jed; McGuire, Jennifer; Ngwenya, Laura 09-01-2020 -08-31-2022 Department of the Army Medical Research Acquisition Activity DM190198 - Rapid Ketone Infusion to Prevent Brain Energy Depletion and Secondary Brain Injury in Severe TBI with Hemorrhagic Shock Role:PI $723,710.00 Awarded Level:Federal

Grant: #OS0002584 07-01-2021 -12-31-2021 Cincinnati Children's Hospital Medical Center Mechanistic studies into the cognitive rescue effect of pioglitazone in chronic TBI Role:PI 12533.18 Hold Level:Non Profit

Grant: #OS0002584 07-01-2021 -12-31-2021 Cincinnati Children's Hospital Medical Center Mechanistic studies into the cognitive rescue effect of pioglitazone in chronic TBI Role:PI 12533.18 Hold Level:Non Profit

Grant: #R01NS129922 Investigators:Hartings, Jed; McGuire, Jennifer; Ngwenya, Laura 12-01-2022 -11-30-2027 National Institute of Neurological Disorders and Stroke Defining the remote effects of cortical spreading depolarizations on hippocampus after traumatic brain injury Role:Collaborator 787983.21 Hold Level:Federal

Grant: #16921 Investigators:Anand, Sam; Forbes, Jonathan; McGuire, Jennifer; Nauman, Eric 07-01-2024 -06-30-2028 Center for Innovative NeuroTech Advancement C1-2 Prosthesis Role:Collaborator 0.00 Hold Level:Non Profit

Peer Reviewed Publications

McGuire J.L.;Correll E.A.;Lowery A.C.;Rhame K.;Anwar F.N.;McCullumsmith R.E.;Ngwenya L.B.  (12-01-2019). Pioglitazone improves working memory performance when administered in chronic TBI. Neurobiology of Disease, 132More Information

Kyser, Tara L; Dourson, Adam J; McGuire, Jennifer L; Hemmerle, Ann M; Williams, Michael T; Seroogy, Kim B  (2019). Characterization of Motor and Non-Motor Behavioral Alterations in the Dj-1 (PARK7) Knockout Rat. Journal of molecular neuroscience : MNMore Information

McGuire, Jennifer L; Correll, Erika A; Lowery, Alexandra C; Rhame, Katherine; Anwar, Fatima N; McCullumsmith, Robert E; Ngwenya, Laura B  (2019). Pioglitazone improves working memory performance when administered in chronic TBI. Neurobiology of disease, 132, 104611More Information

McGuire, Jennifer L; Ngwenya, Laura B; McCullumsmith, Robert E  (2018). Neurotransmitter changes after traumatic brain injury: an update for new treatment strategies. Molecular psychiatryMore Information

McGuire, Jennifer L; DePasquale, Erica A K; Watanabe, Miki; Anwar, Fatima; Ngwenya, Laura B; Atluri, Gowtham; Romick-Rosendale, Lindsey E; McCullumsmith, Robert E; Evanson, Nathan K  (2018). Chronic Dysregulation of Cortical and Subcortical Metabolism After Experimental Traumatic Brain Injury. Molecular neurobiologyMore Information

McGuire J.L.;Depasquale E.A.;Funk A.J.;O'Donnovan S.M.;Hasselfeld K.;Marwaha S.;Hammond J.H.;Hartounian V.;Meador-Woodruff J.H.;Meller J.;McCullumsmith R.E.  (12-01-2017). Abnormalities of signal transduction networks in chronic schizophrenia. npj Schizophrenia, 3 (1) More Information

Dorsett, Christopher R; McGuire, Jennifer L; DePasquale, Erica A K; Gardner, Amanda E; Floyd, Candace L; McCullumsmith, Robert E  (2017). Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury. Journal of neurotrauma, 34 (2) , 263-272More Information

Dorsett, Christopher R; McGuire, Jennifer L; Niedzielko, Tracy L; DePasquale, Erica A K; Meller, Jaroslaw; Floyd, Candace L; McCullumsmith, Robert E  (2017). Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression. Journal of neurotrauma, 34 (1) , 220-234More Information

McGuire, Jennifer L; Depasquale, Erica A; Funk, Adam J; O'Donnovan, Sinead M; Hasselfeld, Kathryn; Marwaha, Shruti; Hammond, John H; Hartounian, Vahram; Meador-Woodruff, James H; Meller, Jarek; McCullumsmith, Robert E  (2017). Abnormalities of signal transduction networks in chronic schizophrenia. NPJ schizophrenia, 3, 30More Information

Castro-Gomes, Vitor; Bergstrom, Hadley C; McGuire, Jennifer L; Parker, Clarissa C; Coyner, Jennifer; Landeira-Fernandez, J; Ursano, Robert J; Palmer, Abraham A; Johnson, Luke R  (2016). A dendritic organization of lateral amygdala neurons in fear susceptible and resistant mice. Neurobiology of learning and memory, 127, 64-71More Information

Coyner, Jennifer; McGuire, Jennifer L; Parker, Clarissa C; Ursano, Robert J; Palmer, Abraham A; Johnson, Luke R  (2014). Mice selectively bred for High and Low fear behavior show differences in the number of pMAPK (p44/42 ERK) expressing neurons in lateral amygdala following Pavlovian fear conditioning. Neurobiology of learning and memory, 112, 195-203More Information

McGuire, Jennifer L; Hammond, John H; Yates, Stefani D; Chen, Dongquan; Haroutunian, Vahram; Meador-Woodruff, James H; McCullumsmith, Robert E  (2014). Altered serine/threonine kinase activity in schizophrenia. Brain research, 1568, 42-54More Information

McGuire, Jennifer L; Bergstrom, Hadley C; Parker, Clarissa C; Le, Thien; Morgan, Maria; Tang, Haiying; Selwyn, Reed G; Silva, Afonso C; Choi, Kwang; Ursano, Robert J; Palmer, Abraham A; Johnson, Luke R  (2013). Traits of fear resistance and susceptibility in an advanced intercross line. The European journal of neuroscience, 38 (9) , 3314-24More Information

McGuire J.L.;Coyner J.L.;Johnson L.R.  (11-19-2012). Rodent models of conditioned fear: Behavioral measures of fear and memory. Methods in Pharmacology and Toxicology, 187-202More Information

Choi, Kwang; Le, Thien; McGuire, Jennifer; Xing, Guoqiang; Zhang, Lei; Li, He; Parker, Clarissa C; Johnson, Luke R; Ursano, Robert J  (2012). Expression pattern of the cannabinoid receptor genes in the frontal cortex of mood disorder patients and mice selectively bred for high and low fear. Journal of psychiatric research, 46 (7) , 882-9More Information

Johnson, Luke R; McGuire, Jennifer; Lazarus, Rachel; Palmer, Abraham A  (2012). Pavlovian fear memory circuits and phenotype models of PTSD. Neuropharmacology, 62 (2) , 638-46More Information

Choi, Kwang H; Le, Thien; McGuire, Jennifer; Coyner, Jennifer; Higgs, Brandon W; Diglisic, Suad; Johnson, Luke R; Benedek, David M; Ursano, Robert J  (2012). Expression profiles of mitochondrial genes in the frontal cortex and the caudate nucleus of developing humans and mice selectively bred for high and low fear. PloS one, 7 (11) , e49183More Information

McGuire J.;Larke L.;Sallee F.;Herman J.;Sah R.  (09-01-2011). Differential regulation of neuropeptide Y in the amygdala and prefrontal cortex during recovery from. Frontiers in Behavioral Neuroscience (SEPTEMBER) More Information

McGuire, Jennifer L; Larke, Lauren E; Sallee, Floyd R; Herman, James P; Sah, Renu  (2011). Differential Regulation of Neuropeptide Y in the Amygdala and Prefrontal Cortex during Recovery from Chronic Variable Stress. Frontiers in behavioral neuroscience, 5, 54More Information

Prager, Eric M; Brielmaier, Jennifer; Bergstrom, Hadley C; McGuire, Jennifer; Johnson, Luke R  (2010). Localization of mineralocorticoid receptors at mammalian synapses. PloS one, 5 (12) , e14344More Information

McGuire, Jennifer; Herman, James P; Ghosal, Sriparna; Eaton, Katherine; Sallee, Floyd R; Sah, Renu  (2009). Acid-sensing by the T cell death-associated gene 8 (TDAG8) receptor cloned from rat brain. Biochemical and biophysical research communications, 386 (3) , 420-5More Information

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