Sara C. Kozma , PhD

Sara Kozma came to the University of Cincinnati in 2003 from the Friedrich Miescher Institute in Basel, Switzerland. She is an associate professor in the Department of Cancer and Cell Biology. Dr. Kozma's laboratory is focused on the S6K/mTOR signal transduction pathway and its role in the control of cell growth. The long-term goals of the Kozma laboratory are (i) to identify the upstream signaling components that integrate nutrient and energy homeostasis with growth factor signaling to control S6K/mTOR function, (ii) to establish the downstream mechanisms by which S6K/mTOR signaling regulates ribosome biogenesis, (iii) to identify the molecular components that link ribosome biogenesis to cell cycle progression, and (IV) to elucidate the role of this pathway in diabetes and cancer. Dr. Kozma's group is currently studying the role of mTOR signaling in hepatocellular carcinogenesis. Towards this end, they have generated a liver-specific conditional mTOR knockout mouse line. With regard to the role of the S6K/mTOR pathway in diabetes, the Kozma laboratory has recently demonstrated that S6K-1 is involved in regulating pancreatic beta cell development. 

Bachelor's Degree: University of Liège 1974 (Zoology)

Certificat de Biophysique: University of Liège 1975 (Biophysics)

Agregation dl'Enseignement Moyen Superieur: University of Liège 1976 (Sciences )

Doctoral Degree: University of Liège 1982 (Zoological Sciences )

Fellowship: Kernforschungszentrum 1983 (Molecular Oncology )

Fellowship: Ludwig Institute for Cancer Research 1987 (Molecular Oncology )

mTOR/S6K pathway in diabetes, mTOR signaling in hepatocellular carcinogenesis

1974 -1981 Graduate Research Assistant and Teaching Assistant, Department of Microbiology, Faculty of Medicine, University of Liège, Belgium

1982 -1983 Post-doctoral Fellow, Kernforschungszentrum, Karlsruhe, Germany

1983 -1987 Post-doctoral Fellow, , Ludwig Institute for Cancer Research, Bern, Switzerland

1987 -2003 Associate Investigator, Friedrich Miescher Institute, Basel, Switzerland

2004 -To Present Associate Professor, Department of Cancer and Cell Biology, Genome Research Institute, University of Cincinnati, Cincinnati, OH

Grant: #R01 DK73802-01A1 Investigators:(PI: G.Thomas) 07-01-2006 -04-30-2011 NIH/ NIDDK “Mechanisms of S6K1 Mediated Insulin Resistance” Active

Grant: #1U01 CA120475-01 Investigators:(PI: SC Kozma) 03-14-2007 -02-29-2012 NIH/NCI “The Role of mTOR Signaling in Hepatocellular Carcinogenesis” Active

Grant: #1R01 DK078019-01 Investigators:(PI: G.Thomas) 07-15-2008 -06-30-2013 NIH/NIDDK “Role of hVps34/mTOR Complex 1 in Amino Acid-Induced Obesity and Insulin Resistance” Active

Investigators:PI: A Drew 07-01-2006 -06-30-2009 American Cancer Society ACS National Award “Interleukin-6 and Ovarian Cancer Metastasis” Active Type:Grant

Grant: #1 P50 NS057531-01 Investigators:(PI: N Ratner) 07-15-2008 -06-30-2013 NIH / NINDS “Signaling Pathways in NF1” Role:Co-Investigator Active

Grant: #115915 03-01-2009 -02-28-2011 Juvenile Diabetes Research Foundation Role:(PI: SC Kozma) Active Type:Grant

Grant: #U01 CA120475 Investigators:Kozma, Sara 03-14-2007 -02-28-2013 National Cancer Institute The Role of mTOR Signaling in Hepatocellular Carcinogenesis Role:PI $1,473,108.00 Closed Level:Federal

Grant: #R01 DK078019 Investigators:Greis, Kenneth; Kozma, Sara; Thomas, George 07-15-2008 -05-31-2013 National Inst of Diabetes and Digestive and Kidney Disease Role of hVps34/mTOR Complex in Amino Acid-Induced Obesity and Insulin Resistance Role:Collaborator $1,371,652.00 Active Level:Federal

Grant: #CHMC 105495 / P50 NS057531 Investigators:Kozma, Sara; Thomas, George 09-15-2008 -06-30-2013 National Institute of Neurological Disorders and Stroke Cincinnati Center for Neurofibromatosis Research Role:Collaborator $1,318,083.00 Active Level:Federal

Grant: #1-2009-293 Investigators:Dalessio, David; Kozma, Sara; Thomas, George 03-01-2009 -02-29-2012 Juvenile Diabetes Research Foundation International Role of mTOR in the Enhancement of Beta-Cell Mass and Function Role:PI $445,500.00 Closed Level:Private Non-Profit

Grant: #3 U01CA120475-03S1 Investigators:Kozma, Sara 08-01-2009 -07-31-2011 National Cancer Institute The Role of mTOR Signaling in Hepatocellular Carcinogenesis Role:PI $397,300.00 Closed Level:Federal

Grant: #U01 CA141464 Investigators:Hui, David; Kozma, Sara; Seeley, Randy; Thomas, George 07-01-2009 -06-30-2014 National Cancer Institute The Effect of Diet and Nutrients on the Progression and Treatment of Prostate Cancer Role:Collaborator $3,062,687.00 Active Level:Federal

Grant: #1 RC1 DK087680-01 Investigators:Fumagalli, Stefano; Kozma, Sara; Thomas, George 09-30-2009 -07-31-2011 National Inst of Diabetes and Digestive and Kidney Disease Model Systems for Hematologic Disorders Caused by Ribosomal Protein Deficiency Role:Collaborator $997,824.00 Closed Level:Federal

Grant: #R01 CA158768 Investigators:Kozma, Sara; Thomas, George 03-01-2012 -02-28-2017 National Cancer Institute The Function of rpL5 and rpL11 in Induction of p53 Role:Collaborator $632,004.00 Active Level:Federal

Grant: #R21CA191814 Investigators:Elnakat, Hala; Kozma, Sara; Mercer, Carol 06-01-2015 -05-31-2017 National Cancer Institute Autophagy, mTOR inhibitors and phenformin in hepatocellular carcinoma Role:Collaborator $221,653.00 Awarded Level:Federal

Peer Reviewed Publications

McFarland-Mancini, Molly M; Funk, Holly M; Paluch, Andrew M; Zhou, Mingfu; Giridhar, Premkumar Vummidi; Mercer, Carol A; Kozma, Sara C; Drew, Angela F (2010. ) Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor.Journal of immunology (Baltimore, Md. : 1950), , 184 (12 ) ,7219-28 More Information

Dowling, Ryan J O; Topisirovic, Ivan; Alain, Tommy; Bidinosti, Michael; Fonseca, Bruno D; Petroulakis, Emmanuel; Wang, Xiaoshan; Larsson, Ola; Selvaraj, Anand; Liu, Yi; Kozma, Sara C; Thomas, George; Sonenberg, Nahum (2010. ) mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.Science (New York, N.Y.), , 328 (5982 ) ,1172-6 More Information

Carnevalli, Larissa S; Masuda, Kouhei; Frigerio, Francesca; Le Bacquer, Olivier; Um, Sung Hee; Gandin, Valentina; Topisirovic, Ivan; Sonenberg, Nahum; Thomas, George; Kozma, Sara C (2010. ) S6K1 plays a critical role in early adipocyte differentiation.Developmental cell, , 18 (5 ) ,763-74 More Information

Montagne, Jacques; Lecerf, Caroline; Parvy, Jean-Philippe; Bennion, Janis M; Radimerski, Thomas; Ruhf, Marie-Laure; Zilbermann, Frederic; Vouilloz, Nicole; Stocker, Hugo; Hafen, Ernst; Kozma, Sara C; Thomas, George (2010. ) The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila.PLoS genetics, , 6 ,e1000937 More Information

Kalender, Adem; Selvaraj, Anand; Kim, So Young; Gulati, Pawan; Brûlé, Sophie; Viollet, Benoit; Kemp, Bruce E; Bardeesy, Nabeel; Dennis, Patrick; Schlager, John J; Marette, André; Kozma, Sara C; Thomas, George (2010. ) Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.Cell metabolism, , 11 (5 ) ,390-401 More Information

Alimonti, Andrea; Nardella, Caterina; Chen, Zhenbang; Clohessy, John G; Carracedo, Arkaitz; Trotman, Lloyd C; Cheng, Ke; Varmeh, Shohreh; Kozma, Sara C; Thomas, George; Rosivatz, Erika; Woscholski, Rudiger; Cognetti, Francesco; Scher, Howard I; Pandolfi, Pier Paolo (2010. ) A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.The Journal of clinical investigation, , 120 (3 ) ,681-93 More Information

Alain, Tommy; Lun, XueQing; Martineau, Yvan; Sean, Polen; Pulendran, Bali; Petroulakis, Emmanuel; Zemp, Franz J; Lemay, Chantal G; Roy, Dominic; Bell, John C; Thomas, George; Kozma, Sara C; Forsyth, Peter A; Costa-Mattioli, Mauro; Sonenberg, Nahum (2010. ) Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production.Proceedings of the National Academy of Sciences of the United States of America, , 107 (4 ) ,1576-81 More Information

Risson, Valérie; Mazelin, Laetitia; Roceri, Mila; Sanchez, Hervé; Moncollin, Vincent; Corneloup, Claudine; Richard-Bulteau, Hélène; Vignaud, Alban; Baas, Dominique; Defour, Aurélia; Freyssenet, Damien; Tanti, Jean-François; Le-Marchand-Brustel, Yannick; Ferrier, Bernard; Conjard-Duplany, Agnès; Romanino, Klaas; Bauché, Stéphanie; Hantaï, Daniel; Mueller, Matthias; Kozma, Sara C; Thomas, George; Rüegg, Markus A; Ferry, Arnaud; Pende, Mario; Bigard, Xavier; Koulmann, Nathalie; Schaeffer, Laurent; Gangloff, Yann-Gaël (2009. ) Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.The Journal of cell biology, , 187 (6 ) ,859-74 More Information

Selman, Colin; Tullet, Jennifer M A; Wieser, Daniela; Irvine, Elaine; Lingard, Steven J; Choudhury, Agharul I; Claret, Marc; Al-Qassab, Hind; Carmignac, Danielle; Ramadani, Faruk; Woods, Angela; Robinson, Iain C A; Schuster, Eugene; Batterham, Rachel L; Kozma, Sara C; Thomas, George; Carling, David; Okkenhaug, Klaus; Thornton, Janet M; Partridge, Linda; Gems, David; Withers, Dominic J (2009. ) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.Science (New York, N.Y.), , 326 (5949 ) ,140-4 More Information

Chen, Jian-Kang; Chen, Jianchun; Thomas, George; Kozma, Sara C; Harris, Raymond C (2009. ) S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy.American journal of physiology. Renal physiology, , 297 (3 ) ,F585-93 More Information

González-Rodriguez, Agueda; Alba, Javier; Zimmerman, Valeri; Kozma, Sara C; Valverde, Angela M (2009. ) S6K1 deficiency protects against apoptosis in hepatocytes.Hepatology (Baltimore, Md.), , 50 (1 ) ,216-29 More Information

Delgoffe, Greg M; Kole, Thomas P; Zheng, Yan; Zarek, Paul E; Matthews, Krystal L; Xiao, Bo; Worley, Paul F; Kozma, Sara C; Powell, Jonathan D (2009. ) The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.Immunity, , 30 (6 ) ,832-44 More Information

Kroczynska, Barbara; Kaur, Surinder; Katsoulidis, Efstratios; Majchrzak-Kita, Beata; Sassano, Antonella; Kozma, Sara C; Fish, Eleanor N; Platanias, Leonidas C (2009. ) Interferon-dependent engagement of eukaryotic initiation factor 4B via S6 kinase (S6K)- and ribosomal protein S6K-mediated signals.Molecular and cellular biology, , 29 (10 ) ,2865-75 More Information

Nardella, Caterina; Carracedo, Arkaitz; Alimonti, Andrea; Hobbs, Robin M; Clohessy, John G; Chen, Zhenbang; Egia, Ainara; Fornari, Alessandro; Fiorentino, Michelangelo; Loda, Massimo; Kozma, Sara C; Thomas, George; Cordon-Cardo, Carlos; Pandolfi, Pier Paolo (2009. ) Differential requirement of mTOR in postmitotic tissues and tumorigenesis.Science signaling, , 2 (55 ) ,ra2 More Information

Carracedo, Arkaitz; Ma, Li; Teruya-Feldstein, Julie; Rojo, Federico; Salmena, Leonardo; Alimonti, Andrea; Egia, Ainara; Sasaki, Atsuo T; Thomas, George; Kozma, Sara C; Papa, Antonella; Nardella, Caterina; Cantley, Lewis C; Baselga, Jose; Pandolfi, Pier Paolo (2008. ) Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.The Journal of clinical investigation, , 118 (9 ) ,3065-74 More Information

Gulati, Pawan; Gaspers, Lawrence D; Dann, Stephen G; Joaquin, Manel; Nobukuni, Takahiro; Natt, Francois; Kozma, Sara C; Thomas, Andrew P; Thomas, George (2008. ) Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.Cell metabolism, , 7 (5 ) ,456-65 More Information

Johansson, Gunnar; Mahller, Yonatan Y; Collins, Margaret H; Kim, Mi-Ok; Nobukuni, Takahiro; Perentesis, John; Cripe, Timothy P; Lane, Heidi A; Kozma, Sara C; Thomas, George; Ratner, Nancy (2008. ) Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors.Molecular cancer therapeutics, , 7 (5 ) ,1237-45 More Information

Antion, Marcia D; Merhav, Maayan; Hoeffer, Charles A; Reis, Gerald; Kozma, Sara C; Thomas, George; Schuman, Erin M; Rosenblum, Kobi; Klann, Eric (2008. ) Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity.Learning & memory (Cold Spring Harbor, N.Y.), , 15 (1 ) ,29-38 More Information

Dufour, Jean-François; Huber, Otmar; Kozma, Sara C; Lu, Xin; Toftgård, Rune (2007. ) Tumour suppressors in liver carcinogenesis.Journal of hepatology, , 47 (6 ) ,860-7 More Information

Nobukuni, Takahiro; Kozma, Sara C; Thomas, George (2007. ) hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling.Current opinion in cell biology, , 19 (2 ) ,135-41 More Information

Chalhoub, Nader; Kozma, Sara C; Baker, Suzanne J (2006. ) S6k1 is not required for Pten-deficient neuronal hypertrophy.Brain research, , 1100 (1 ) ,32-41 More Information

Cota, Daniela; Proulx, Karine; Smith, Kathi A Blake; Kozma, Sara C; Thomas, George; Woods, Stephen C; Seeley, Randy J (2006. ) Hypothalamic mTOR signaling regulates food intake.Science (New York, N.Y.), , 312 (5775 ) ,927-30 More Information

Gangloff, Yann-Gaël; Mueller, Matthias; Dann, Stephen G; Svoboda, Petr; Sticker, Melanie; Spetz, Jean-Francois; Um, Sung Hee; Brown, Eric J; Cereghini, Silvia; Thomas, George; Kozma, Sara C (2004. ) Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development.Molecular and cellular biology, , 24 (21 ) ,9508-16 More Information

Um, Sung Hee; Frigerio, Francesca; Watanabe, Mitsuhiro; Picard, Frédéric; Joaquin, Manel; Sticker, Melanie; Fumagalli, Stefano; Allegrini, Peter R; Kozma, Sara C; Auwerx, Johan; Thomas, George (2004. ) Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity.Nature, , 431 (7005 ) ,200-5 More Information

Pende, Mario; Um, Sung Hee; Mieulet, Virginie; Sticker, Melanie; Goss, Valerie L; Mestan, Jurgen; Mueller, Matthias; Fumagalli, Stefano; Kozma, Sara C; Thomas, George (2004. ) S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Molecular and cellular biology, , 24 (8 ) ,3112-24

Turck, Franziska; Zilbermann, Frederic; Kozma, Sara C; Thomas, George; Nagy, Ferenc (2004. ) Phytohormones participate in an S6 kinase signal transduction pathway in Arabidopsis.Plant physiology, , 134 (4 ) ,1527-35 More Information

Garami, Attila; Zwartkruis, Fried J T; Nobukuni, Takahiro; Joaquin, Manel; Roccio, Marta; Stocker, Hugo; Kozma, Sara C; Hafen, Ernst; Bos, Johannes L; Thomas, George (2003. ) Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Molecular cell, , 11 (6 ) ,1457-66

Patel, Satish; Lochhead, Pamela A; Rena, Graham; Fumagalli, Stefano; Pende, Mario; Kozma, Sara C; Thomas, George; Sutherland, Calum (2002. ) Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity.The Journal of biological chemistry, , 277 (12 ) ,9889-95 More Information

Kozma, Sara C; Thomas, George (2002. ) Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.BioEssays : news and reviews in molecular, cellular and developmental biology, , 24 (1 ) ,65-71 More Information

Dennis, P B; Jaeschke, A; Saitoh, M; Fowler, B; Kozma, S C; Thomas, G (2001. ) Mammalian TOR: a homeostatic ATP sensor.Science (New York, N.Y.), , 294 (5544 ) ,1102-5 More Information

Pende, M; Kozma, S C; Jaquet, M; Oorschot, V; Burcelin, R; Le Marchand-Brustel, Y; Klumperman, J; Thorens, B; Thomas, G Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.Nature, , 408 (6815 ) ,994-7 More Information

Volarevic, S; Stewart, M J; Ledermann, B; Zilberman, F; Terracciano, L; Montini, E; Grompe, M; Kozma, S C; Thomas, G (2000. ) Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6. Science (New York, N.Y.), , 288 (5473 ) ,2045-7

Coulonval, K; Vandeput, F; Stein, R C; Kozma, S C; Lamy, F; Dumont, J E (2000. ) Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin. The Biochemical journal, , 348 Pt 2 ,351-8

Montagne, J; Stewart, M J; Stocker, H; Hafen, E; Kozma, S C; Thomas, G (1999. ) Drosophila S6 kinase: a regulator of cell size. Science (New York, N.Y.), , 285 (5436 ) ,2126-9

Schwab, M S; Kim, S H; Terada, N; Edfjäll, C; Kozma, S C; Thomas, G; Maller, J L (1999. ) p70(S6K) controls selective mRNA translation during oocyte maturation and early embryogenesis in Xenopus laevis. Molecular and cellular biology, , 19 (4 ) ,2485-94

Shima, H; Pende, M; Chen, Y; Fumagalli, S; Thomas, G; Kozma, S C (1998. ) Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.The EMBO journal, , 17 (22 ) ,6649-59 More Information

Dennis, P B; Pullen, N; Pearson, R B; Kozma, S C; Thomas, G (1998. ) Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation. The Journal of biological chemistry, , 273 (24 ) ,14845-52

Turck, F; Kozma, S C; Thomas, G; Nagy, F (1998. ) A heat-sensitive Arabidopsis thaliana kinase substitutes for human p70s6k function in vivo. Molecular and cellular biology, , 18 (4 ) ,2038-44

Pullen, N; Dennis, P B; Andjelkovic, M; Dufner, A; Kozma, S C; Hemmings, B A; Thomas, G (1998. ) Phosphorylation and activation of p70s6k by PDK1. Science (New York, N.Y.), , 279 (5351 ) ,707-10

Moser, B A; Dennis, P B; Pullen, N; Pearson, R B; Williamson, N A; Wettenhall, R E; Kozma, S C; Thomas, G (1997. ) Dual requirement for a newly identified phosphorylation site in p70s6k. Molecular and cellular biology, , 17 (9 ) ,5648-55

Dennis, P B; Pullen, N; Kozma, S C; Thomas, G (1996. ) The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases. Molecular and cellular biology, , 16 (11 ) ,6242-51

Stewart, M J; Berry, C O; Zilberman, F; Thomas, G; Kozma, S C (1996. ) The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity. Proceedings of the National Academy of Sciences of the United States of America, , 93 (20 ) ,10791-6

Pearson, R B; Dennis, P B; Han, J W; Williamson, N A; Kozma, S C; Wettenhall, R E; Thomas, G (1995. ) The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. The EMBO journal, , 14 (21 ) ,5279-87

Ming, X F; Burgering, B M; Wennström, S; Claesson-Welsh, L; Heldin, C H; Bos, J L; Kozma, S C; Thomas, G (1994. ) Activation of p70/p85 S6 kinase by a pathway independent of p21ras.Nature, , 371 (6496 ) ,426-9 More Information

Kozma, S C; Thomas, G (1994. ) p70s6k/p85s6k: mechanism of activation and role in mitogenesis. Seminars in cancer biology, , 5 (4 ) ,255-60

Jefferies, H B; Reinhard, C; Kozma, S C; Thomas, G (1994. ) Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Proceedings of the National Academy of Sciences of the United States of America, , 91 (10 ) ,4441-5

Ferrari, S; Pearson, R B; Siegmann, M; Kozma, S C; Thomas, G (1993. ) The immunosuppressant rapamycin induces inactivation of p70s6k through dephosphorylation of a novel set of sites. The Journal of biological chemistry, , 268 (22 ) ,16091-4

Kozma, S C; McGlynn, E; Siegmann, M; Reinhard, C; Ferrari, S; Thomas, G (1993. ) Active baculovirus recombinant p70s6k and p85s6k produced as a function of the infectious response. The Journal of biological chemistry, , 268 (10 ) ,7134-8

Lane, H A; Morley, S J; Dorée, M; Kozma, S C; Thomas, G (1992. ) Identification and early activation of a Xenopus laevis p70s6k following progesterone-induced meiotic maturation. The EMBO journal, , 11 (5 ) ,1743-9

Reinhard, C; Thomas, G; Kozma, S C (1992. ) A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation. Proceedings of the National Academy of Sciences of the United States of America, , 89 (9 ) ,4052-6

Kozma, S C; Thomas, G (1992. ) Serine/threonine kinases in the propagation of the early mitogenic response. Reviews of physiology, biochemistry and pharmacology, , 119 ,123-55

Kozma, S C; Ferrari, S; Bassand, P; Siegmann, M; Totty, N; Thomas, G (1990. ) Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily. Proceedings of the National Academy of Sciences of the United States of America, , 87 (19 ) ,7365-9

Kozma, S C; Lane, H A; Ferrari, S; Luther, H; Siegmann, M; Thomas, G (1989. ) A stimulated S6 kinase from rat liver: identity with the mitogen activated S6 kinase of 3T3 cells. The EMBO journal, , 8 (13 ) ,4125-32

Kozma, S C; Ferrari, S; Thomas, G (1989. ) Unmasking a growth factor/oncogene-activated S6 phosphorylation cascade. Cellular signalling, , 1 (3 ) ,219-25

Ziemiecki, A; Mueller, R G; Hynes, N E; Krieg, J; Kozma, S C (1988. ) cDNA sequence of the human ribosomal large subunit protein L7a. Nucleic acids research, , 16 (21 ) ,10356

Kozma, S C; Redmond, S M; Fu, X C; Saurer, S M; Groner, B; Hynes, N E (1988. ) Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences. The EMBO journal, , 7 (1 ) ,147-54

Kozma, S C; Bogaard, M E; Buser, K; Saurer, S M; Bos, J L; Groner, B; Hynes, N E (1987. ) The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231. Nucleic acids research, , 15 (15 ) ,5963-71

Hynes, N E; Jaggi, R; Kozma, S C; Ball, R; Muellener, D; Wetherall, N T; Davis, B W; Groner, B (1985. ) New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line. Molecular and cellular biology, , 5 (1 ) ,268-72

1974 -1976 Graduate Scholarship from the IRSIA, Belgium University of Liège, Belgium

1976 -1981 Belgian State Teaching Assistantship University of Liège, Belgium

1982 -1983 Research Fellowship from the Gertrud Hagmann Foundation for Cancer Research, Switzerland Status:Recipient Type:Fellowship

1983 -1987 Research Fellowship from the Ludwig Institute for Cancer Research Bern, Switzerland Basel, Switzerland Status:Recipient Type:Fellowship

1996 -1999 Co-applicant of Swiss Cancer League Grant: SKL 284-2-96

1997 -2000 Participant member of EEC Grant Biotechnology: PL96201: Identification of signal transduction molecules as targets for biotechnology derived immunosuppressive drugs

2005 -2008 Reviewer, American Cancer Society, Tumor Biochemistry and Endocrinology Study Section

2007 -To Present External member of the Hungarian Academy of Sciences

Academic - Reading Campus
2180 E. Galbraith Rd
Reading  Ohio, 45215
Phone: 513-558-8112
Fax: 513-558-5061
sara.kozma@uc.edu